Miguel Ribeiro, Margarida Sousa, Vítor Borges, João Paulo Gomes, Sílvia Duarte, Joana Isidro, Luís Vieira, Carmen Torres, Hugo Santos, José Luís Capelo, Patrícia Poeta, Gilberto Igrejas
One of the most important livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) genetic lineages is the clonal complex (CC) 398, which can cause typical S. aureus-associated infections in people. In this work, whole-genome sequencing, RNA-sequencing, and gel-based comparative proteomics were applied to study the genetic characteristics of three MRSA CC398 isolates recovered from humans (strains C5621 and C9017), and from an animal (strain OR418). Of the three strains, C9017 presented the broadest resistance genotype, including resistance to fluroquinolone, clindamycin, tiamulin, macrolide and aminoglycoside antimicrobial classes...
September 1, 2022: Journal of Proteomics