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https://www.readbyqxmd.com/read/28645061/the-neurochemical-consequences-of-methamphetamine-self-administration-in-male-and-female-rats
#1
Andrew Johansen, Lisa M McFadden
BACKGROUND: Methamphetamine (METH) is an addictive substance that is used in both males and females. Few preclinical studies have focused on understanding sex-differences in the neurochemical consequences of contingent METH. The purpose of the current study was to investigate potential sex-differences in the neurochemical consequences of METH self-administration. METHODS: Male and female adult rats were given extended access to METH or saline self-administration for 7d...
June 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28448903/violence-trauma-and-living-with-hiv-longitudinal-predictors-of-initiating-crystal-methamphetamine-injection-among-sex-workers
#2
Elena Argento, Steffanie A Strathdee, Shira Goldenberg, Melissa Braschel, Julio Montaner, Kate Shannon
BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access)...
April 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28379107/gender-and-sex-trading-among-active-methamphetamine-users-in-cape-town-south-africa
#3
Ryan R Lion, Melissa H Watt, Wendee M Wechsberg, Christina S Meade
BACKGROUND: South Africa has experienced a tremendous rise in methamphetamine use since the year 2000. Sex trading is a global phenomenon that has been observed in active drug users and has been associated with risks for HIV infection and violence. OBJECTIVES: This paper describes and examines the correlates of sex trading among active methamphetamine users in Cape Town, South Africa. METHODS: Through peer referral, 360 (201 male; 159 female) active methamphetamine users were recruited in a peri-urban township...
May 12, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28222753/evaluation-of-blood-lead-level-in-methamphetamine-users-in-tehran
#4
Babak Mostafazadeh, Shahin Shadnia, Mohammad Ali Tavakkoli, Hamid Reza Khoddami Vishteh
BACKGROUND: Given the increasing number of lead poisoning in opioids users and since no study has been conducted so far to review lead poisoning in methamphetamine (crystal) users, this study aimed to investigate blood lead level in methamphetamine addicts. METHODS: This study was conducted on 20 patients with methamphetamine poisoning and their blood lead level was measured. The subjects were selected from among patients with a history of continuous use of methamphetamine, without a history of using opiates in the past 6 months confirmed by a negative urine tests, and without a history of heavy metal poisoning...
February 22, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28178893/sexually-transmitted-infection-prevalence-and-related-risk-factors-among-heterosexual-male-methamphetamine-users-in-china
#5
Dianchang Liu, Zhenxia Jiang, Cuizhen Xiu, Zhizhi Li, Qing Song, Zhenhong Wang
Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11.0. Among the 288 heterosexual male MA users, 51 (17.7%) had syphilis, 36 (12...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28110822/oxytocin-acts-in-nucleus-accumbens-to-attenuate-methamphetamine-seeking-and-demand
#6
Brittney M Cox, Brandon S Bentzley, Helaina Regen-Tuero, Ronald E See, Carmela M Reichel, Gary Aston-Jones
BACKGROUND: Evidence indicates that oxytocin, an endogenous peptide well known for its role in social behaviors, childbirth, and lactation, is a promising addiction pharmacotherapy. We employed a within-session behavioral-economic (BE) procedure in rats to examine oxytocin as a pharmacotherapy for methamphetamine (meth) addiction. The BE paradigm was modeled after BE procedures used to assess motivation for drugs in humans with addiction. The same BE variables assessed across species have been shown to predict later relapse behavior...
June 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/27803891/a-qualitative-study-of-the-relationship-between-methamphetamine-abuse-and-sexual-dysfunction-in-male-substance-abusers
#7
Behrouz Dolatshahi, Ali Farhoudian, Mozhgan Falahatdoost, Mahmoud Tavakoli, Ebrahim Rezaie Dogahe
BACKGROUND: Increased prevalent use of methamphetamine is a global public challenge. Information on drug use can be helpful in preventing high-risk behavior related to drug abuse. OBJECTIVES: This study aims to investigate the sexual function changes related to methamphetamine use in the male clients of public and private addiction treatment centers. PATIENTS AND METHODS: In this qualitative study, 45 men (35 methamphetamine users, 5 family members of the users, and 5 psychiatrists or physicians who were famous for treating or researching addiction) are involved...
September 2016: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/27246967/intimate-partner-violence-among-men-and-women-who-use-methamphetamine-a-mixed-methods-study-in-south-africa
#8
Melissa H Watt, Kathryn E Guidera, Andréa L Hobkirk, Donald Skinner, Christina S Meade
INTRODUCTION: The prevalence of methamphetamine use has risen dramatically in parts of South Africa. Globally, methamphetamine has been linked to intimate partner violence (IPV) and other forms of aggression. The aim of this mixed-methods study was to examine the experiences of physical IPV and its contextual factors among methamphetamine users in an urban community in Cape Town, South Africa. METHODS: Active methamphetamine users were recruited using respondent driven sampling...
January 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/27223864/reactivity-to-addictive-drugs-in-the-methylazoxymethanol-mam-model-of-schizophrenia-in-male-and-female-rats
#9
Jana Ruda-Kucerova, Zuzana Babinska, Petra Amchova, Tibor Stark, Filippo Drago, Alexandra Sulcova, Vincenzo Micale
OBJECTIVES: Patients with schizophrenia often suffer comorbid substance abuse regardless of gender. However, the vast majority of studies are only conducted in male subjects. Therefore, the aim of these experiments is to assess addictive behaviors of both sexes in a neurodevelopmental model of schizophrenia induced by prenatal methylazoxymethanol (MAM) acetate exposure. METHODS: MAM (22 mg/kg) was administered intraperitoneally on gestational day 17. Two studies were performed in the offspring: (1) an alcohol-drinking procedure to assess daily intake of 20% alcohol and relapse-like behavior after a period of forced abstinence; (2) Methamphetamine (METH) intravenous self administration (IVSA) followed by forced abstinence and reinstatement phases...
June 21, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27095357/sex-differences-in-impulsivity-and-brain-morphometry-in-methamphetamine-users
#10
Shannon Kogachi, Linda Chang, Daniel Alicata, Eric Cunningham, Thomas Ernst
Methamphetamine (METH) is an addictive stimulant, and METH users have abnormal brain structures and function. The aims of this study were to investigate the relationships between impulsivity, brain structures, and possible sex-specific differences between METH users and non-drug using Controls. Structural MRI and the Barratt Impulsiveness Scale (BIS) questionnaire were completed in 124 subjects: 62 METH (ages 41.2 ± 1.4 years, 34 males) and 62 Controls (ages 43.3 ± 2.3 years, 36 males). Independent and interactive effects of METH use status and sex were evaluated...
January 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/26519763/childhood-trauma-and-meth-abuse-among-men-who-have-sex-with-men-implications-for-intervention
#11
Maria Lopez-Patton, Mahendra Kumar, Deborah Jones, Marla Fonseca, Adarsh M Kumar, Charles B Nemeroff
Methamphetamine (METH) has become one of the most widely abused drugs in South Florida, particularly among MSM who may or may not be HIV seropositive. High rates of childhood trauma have been reported among HIV-infected MSM (Chartier et al., 2010), but, the association of childhood trauma, and mood disorders with methamphetamine use in HIV-infected men, has not been comprehensively explored. A better understanding of the association between these factors could improve existing substance abuse treatment intervention strategies and medical treatment programs (e...
January 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/25622123/impact-of-prospectively-determined-a118g-polymorphism-on-treatment-response-to-injectable-naltrexone-among-methamphetamine-dependent-patients-an-open-label-pilot-study
#12
Reshmi Pal, John E Mendelson, Keith Flower, Kathleen Garrison, Garret Yount, Jeremy R Coyle, Gantt P Galloway
OBJECTIVES: Methamphetamine (MA) addiction has no known effective pharmacotherapy. Small trials showed beneficial effects for oral naltrexone in amphetamine users. Trials in alcohol-dependent subjects showed better response in persons with the A118G single nucleotide polymorphism of the μ-opioid receptor. We conducted a pharmacogenetic trial of sustained release intramuscular naltrexone to examine the role of the A118G single nucleotide polymorphism in MA dependence. METHOD: All eligible A118G subjects screened were enrolled; an equal number of wild type (A118A) subjects were selected using modified urn randomization, balanced on sex and frequency of recent MA use...
March 2015: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/25567071/-nothing-is-free-a-qualitative-study-of-sex-trading-among-methamphetamine-users-in-cape-town-south-africa
#13
Melissa H Watt, Stephen M Kimani, Donald Skinner, Christina S Meade
South Africa is facing an established epidemic of methamphetamine, known locally as "tik." Globally, methamphetamine has been linked to high rates of sexual risk behaviors, including sex trading. The goal of this study was to qualitatively examine the experiences of sex trading among methamphetamine users in Cape Town, South Africa. Individual in-depth interviews were conducted with 30 active methamphetamine users (17 men and 13 women) recruited from the community. Interviews were conducted in local languages using a semi-structured guide that included questions on sex trading experiences and perceptions of sex trading among methamphetamine users...
May 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/25496784/adolescent-exposure-to-cocaine-amphetamine-and-methylphenidate-cross-sensitizes-adults-to-methamphetamine-with-drug-and-sex-specific-effects
#14
Ryan A Shanks, Jordan M Ross, Hillary H Doyle, Amanda K Helton, Brittany N Picou, Jordyn Schulz, Chris Tavares, Sarah Bryant, Bryan L Dawson, Steven A Lloyd
The increasing availability, over-prescription, and misuse and abuse of ADHD psychostimulant medications in adolescent populations necessitates studies investigating the long-term effects of these drugs persisting into adulthood. Male and female C57Bl/6J mice were exposed to amphetamine (AMPH) (1.0 and 10 mg/kg), methylphenidate (MPD) (1.0 and 10 mg/kg), or cocaine (COC) (5.0 mg/kg) from postnatal day 22 to 31, which represents an early adolescent period. After an extended period of drug abstinence, adult mice were challenged with a subacute methamphetamine (METH) dose (0...
March 15, 2015: Behavioural Brain Research
https://www.readbyqxmd.com/read/25175867/interactions-of-hiv-and-drugs-of-abuse-the-importance-of-glia-neural-progenitors-and-host-genetic-factors
#15
REVIEW
Kurt F Hauser, Pamela E Knapp
Considerable insight has been gained into the comorbid, interactive effects of HIV and drug abuse in the brain using experimental models. This review, which considers opiates, methamphetamine, and cocaine, emphasizes the importance of host genetics and glial plasticity in driving the pathogenic neuron remodeling underlying neuro-acquired immunodeficiency syndrome and drug abuse comorbidity. Clinical findings are less concordant than experimental work, and the response of individuals to HIV and to drug abuse can vary tremendously...
2014: International Review of Neurobiology
https://www.readbyqxmd.com/read/25069257/-reconsideration-of-nicotine-and-other-substance-dependence-a-clue-from-dependence-related-mentation-including-reward-motivation-learning-delusion-and-hallucination-toward-understanding-the-concept-of-non-substance-related-addiction
#16
REVIEW
Hisatsugu Miyata
Nicotine produces core symptoms of substance dependence (craving and withdrawal) without any psychotic symptoms. The psychopharmacological structure of craving is hypothesized to be constituted by three components: the primary reinforcing property of a substance, the secondary reinforcing property of that substance (conditioned aspects of the environment, such as contextual or specific cues associated with substance taking), and the negative affective motivational property during withdrawal (i.e. the desire to avoid the dysphoric withdrawal symptoms elicits craving)...
November 2013: Nihon Shinkei Seishin Yakurigaku Zasshi, Japanese Journal of Psychopharmacology
https://www.readbyqxmd.com/read/25035700/comparison-of-brain-white-matter-hyperintensities-in-methamphetamine-and-methadone-dependent-patients-and-healthy-controls
#17
Abdulrasool Alaee, Mehran Zarghami, Samaneh Farnia, Mohammad Khademloo, Talayeh Khoddad
BACKGROUND: Previous studies have proven the development of white matter hyperintensities (WMH) in methamphetamine and opioid users. Opiates and methamphetamines (MA) are the most common addictive agents in Iran. The adverse effects of drugs on the CNS is of concern to specialists and researchers, and given that the neurotoxicity associated with methamphetamine is greater than opioids, it is hypothesized that the severity of WMH in patients with methamphetamine dependence is more than opioid drug-dependent individuals...
May 2014: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/24971258/the-comparison-of-self-regulation-and-affective-control-in-methamphetamine-and-narcotics-addicts-and-non-addicts
#18
Kolthoum Tayyebi, Abbas Abolghasemi, Majid Mahmood Alilu, Nader Monirpoor
BACKGROUND: Increased prevalence and widespread use of methamphetamine is the public challenge and worry in the world. It seems that low levels of self-regulation and affective control to carry up probability of psychoactive drugs abuse. OBJECTIVES: The purpose of the present study is the comparison of self-regulation and affective control in methamphetamine and narcotics addicts and non-addicts. MATERIALS AND METHODS: In this causative-comparative study, 80 addicts (40 methamphetamine addicts and 40 narcotic addicts) who referred to self-reference quitting addictive centers in Miyaneh, Iran, participated in convenience sampling...
2013: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/24876234/further-characterization-of-quinpirole-elicited-yawning-as-a-model-of-dopamine-d3-receptor-activation-in-male-and-female-monkeys
#19
Susan E Martelle, Susan H Nader, Paul W Czoty, William S John, Angela N Duke, Pradeep K Garg, Sudha Garg, Amy H Newman, Michael A Nader
The dopamine (DA) D3 receptor (D3R) has been associated with impulsivity, pathologic gambling, and drug addiction, making it a potential target for pharmacotherapy development. Positron emission tomography studies using the D3R-preferring radioligand [(11)C]PHNO ([(11)C](+)-propyl-hexahydro-naphtho-oxazin) have shown higher binding potentials in drug abusers compared with control subjects. Preclinical studies have examined D3R receptor activation using the DA agonist quinpirole and the unconditioned behavior of yawning...
August 2014: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/24851122/a-pilot-study-for-discovering-candidate-genes-of-chromosome-18q21-in-methamphetamine-abusers-case-control-association-study
#20
Byung Dae Lee, Je Min Park, Young Min Lee, Eun Soo Moon, Hee Jeong Jeong, Young In Chung, Hyo Deog Rim
OBJECTIVE: It was previously suggested that the malic enzyme 2 (ME2) as the candidate gene for psychosis in fine mapping of chromosome 18q21. Chromosome 18q21 is also one of the possible regions that can contribute to addiction. METHODS: We performed a pilot study for discovering candidate gene of chromosome 18q21 in the methamphetamine abusers for elucidating the candidate gene for methamphetamine addiction leading to psychosis. We have selected 30 unrelated controls (16 males, 14 females; age=59...
April 2014: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
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