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methamphetamine/sex addiction

Melissa H Watt, Kathryn E Guidera, Andréa L Hobkirk, Donald Skinner, Christina S Meade
INTRODUCTION: The prevalence of methamphetamine use has risen dramatically in parts of South Africa. Globally, methamphetamine has been linked to intimate partner violence (IPV) and other forms of aggression. The aim of this mixed-methods study was to examine the experiences of physical IPV and its contextual factors among methamphetamine users in an urban community in Cape Town, South Africa. METHODS: Active methamphetamine users were recruited using respondent driven sampling...
June 1, 2016: Drug and Alcohol Review
Jana Ruda-Kucerova, Zuzana Babinska, Petra Amchova, Tibor Stark, Filippo Drago, Alexandra Sulcova, Vincenzo Micale
OBJECTIVES: Patients with schizophrenia suffer comorbid substance abuse regardless of gender. However, the vast majority of studies are only conducted in male subjects. Therefore, the aim of these experiments is to assess addictive behaviors of both sexes in a neurodevelopmental model of schizophrenia induced by prenatal methylazoxymethanol acetate (MAM) exposure. METHODS: MAM was administered intraperitoneally (22 mg/kg on gestational day 17). Two studies were performed in the offspring: (1) alcohol drinking procedure to assess daily intake of 20% alcohol and relapse-like behavior after a period of forced abstinence...
May 25, 2016: World Journal of Biological Psychiatry
Shannon Kogachi, Linda Chang, Daniel Alicata, Eric Cunningham, Thomas Ernst
Methamphetamine (METH) is an addictive stimulant, and METH users have abnormal brain structures and function. The aims of this study were to investigate the relationships between impulsivity, brain structures, and possible sex-specific differences between METH users and non-drug using Controls. Structural MRI and the Barratt Impulsiveness Scale (BIS) questionnaire were completed in 124 subjects: 62 METH (ages 41.2 ± 1.4 years, 34 males) and 62 Controls (ages 43.3 ± 2.3 years, 36 males). Independent and interactive effects of METH use status and sex were evaluated...
April 19, 2016: Brain Structure & Function
Maria Lopez-Patton, Mahendra Kumar, Deborah Jones, Marla Fonseca, Adarsh M Kumar, Charles B Nemeroff
Methamphetamine (METH) has become one of the most widely abused drugs in South Florida, particularly among MSM who may or may not be HIV seropositive. High rates of childhood trauma have been reported among HIV-infected MSM (Chartier et al., 2010), but, the association of childhood trauma, and mood disorders with methamphetamine use in HIV-infected men, has not been comprehensively explored. A better understanding of the association between these factors could improve existing substance abuse treatment intervention strategies and medical treatment programs (e...
January 2016: Journal of Psychiatric Research
Reshmi Pal, John E Mendelson, Keith Flower, Kathleen Garrison, Garret Yount, Jeremy R Coyle, Gantt P Galloway
OBJECTIVES: Methamphetamine (MA) addiction has no known effective pharmacotherapy. Small trials showed beneficial effects for oral naltrexone in amphetamine users. Trials in alcohol-dependent subjects showed better response in persons with the A118G single nucleotide polymorphism of the μ-opioid receptor. We conducted a pharmacogenetic trial of sustained release intramuscular naltrexone to examine the role of the A118G single nucleotide polymorphism in MA dependence. METHOD: All eligible A118G subjects screened were enrolled; an equal number of wild type (A118A) subjects were selected using modified urn randomization, balanced on sex and frequency of recent MA use...
March 2015: Journal of Addiction Medicine
Melissa H Watt, Stephen M Kimani, Donald Skinner, Christina S Meade
South Africa is facing an established epidemic of methamphetamine, known locally as "tik." Globally, methamphetamine has been linked to high rates of sexual risk behaviors, including sex trading. The goal of this study was to qualitatively examine the experiences of sex trading among methamphetamine users in Cape Town, South Africa. Individual in-depth interviews were conducted with 30 active methamphetamine users (17 men and 13 women) recruited from the community. Interviews were conducted in local languages using a semi-structured guide that included questions on sex trading experiences and perceptions of sex trading among methamphetamine users...
May 2016: Archives of Sexual Behavior
Ryan A Shanks, Jordan M Ross, Hillary H Doyle, Amanda K Helton, Brittany N Picou, Jordyn Schulz, Chris Tavares, Sarah Bryant, Bryan L Dawson, Steven A Lloyd
The increasing availability, over-prescription, and misuse and abuse of ADHD psychostimulant medications in adolescent populations necessitates studies investigating the long-term effects of these drugs persisting into adulthood. Male and female C57Bl/6J mice were exposed to amphetamine (AMPH) (1.0 and 10 mg/kg), methylphenidate (MPD) (1.0 and 10 mg/kg), or cocaine (COC) (5.0 mg/kg) from postnatal day 22 to 31, which represents an early adolescent period. After an extended period of drug abstinence, adult mice were challenged with a subacute methamphetamine (METH) dose (0...
March 15, 2015: Behavioural Brain Research
Kurt F Hauser, Pamela E Knapp
Considerable insight has been gained into the comorbid, interactive effects of HIV and drug abuse in the brain using experimental models. This review, which considers opiates, methamphetamine, and cocaine, emphasizes the importance of host genetics and glial plasticity in driving the pathogenic neuron remodeling underlying neuro-acquired immunodeficiency syndrome and drug abuse comorbidity. Clinical findings are less concordant than experimental work, and the response of individuals to HIV and to drug abuse can vary tremendously...
2014: International Review of Neurobiology
Hisatsugu Miyata
Nicotine produces core symptoms of substance dependence (craving and withdrawal) without any psychotic symptoms. The psychopharmacological structure of craving is hypothesized to be constituted by three components: the primary reinforcing property of a substance, the secondary reinforcing property of that substance (conditioned aspects of the environment, such as contextual or specific cues associated with substance taking), and the negative affective motivational property during withdrawal (i.e. the desire to avoid the dysphoric withdrawal symptoms elicits craving)...
November 2013: Nihon Shinkei Seishin Yakurigaku Zasshi, Japanese Journal of Psychopharmacology
Abdulrasool Alaee, Mehran Zarghami, Samaneh Farnia, Mohammad Khademloo, Talayeh Khoddad
BACKGROUND: Previous studies have proven the development of white matter hyperintensities (WMH) in methamphetamine and opioid users. Opiates and methamphetamines (MA) are the most common addictive agents in Iran. The adverse effects of drugs on the CNS is of concern to specialists and researchers, and given that the neurotoxicity associated with methamphetamine is greater than opioids, it is hypothesized that the severity of WMH in patients with methamphetamine dependence is more than opioid drug-dependent individuals...
May 2014: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Kolthoum Tayyebi, Abbas Abolghasemi, Majid Mahmood Alilu, Nader Monirpoor
BACKGROUND: Increased prevalence and widespread use of methamphetamine is the public challenge and worry in the world. It seems that low levels of self-regulation and affective control to carry up probability of psychoactive drugs abuse. OBJECTIVES: The purpose of the present study is the comparison of self-regulation and affective control in methamphetamine and narcotics addicts and non-addicts. MATERIALS AND METHODS: In this causative-comparative study, 80 addicts (40 methamphetamine addicts and 40 narcotic addicts) who referred to self-reference quitting addictive centers in Miyaneh, Iran, participated in convenience sampling...
2013: International Journal of High Risk Behaviors & Addiction
Susan E Martelle, Susan H Nader, Paul W Czoty, William S John, Angela N Duke, Pradeep K Garg, Sudha Garg, Amy H Newman, Michael A Nader
The dopamine (DA) D3 receptor (D3R) has been associated with impulsivity, pathologic gambling, and drug addiction, making it a potential target for pharmacotherapy development. Positron emission tomography studies using the D3R-preferring radioligand [(11)C]PHNO ([(11)C](+)-propyl-hexahydro-naphtho-oxazin) have shown higher binding potentials in drug abusers compared with control subjects. Preclinical studies have examined D3R receptor activation using the DA agonist quinpirole and the unconditioned behavior of yawning...
August 2014: Journal of Pharmacology and Experimental Therapeutics
Byung Dae Lee, Je Min Park, Young Min Lee, Eun Soo Moon, Hee Jeong Jeong, Young In Chung, Hyo Deog Rim
OBJECTIVE: It was previously suggested that the malic enzyme 2 (ME2) as the candidate gene for psychosis in fine mapping of chromosome 18q21. Chromosome 18q21 is also one of the possible regions that can contribute to addiction. METHODS: We performed a pilot study for discovering candidate gene of chromosome 18q21 in the methamphetamine abusers for elucidating the candidate gene for methamphetamine addiction leading to psychosis. We have selected 30 unrelated controls (16 males, 14 females; age=59...
April 2014: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Adam W Carrico, Annesa Flentje, Valerie A Gruber, William J Woods, Michael V Discepola, Samantha E Dilworth, Torsten B Neilands, Jennifer Jain, Michael D Siever
Harm reduction approaches endeavor to assist individuals with avoiding the most detrimental consequences of risk taking behaviors, but limited research has documented the outcomes of harm reduction substance abuse treatment. In total, 211 methamphetamine-using men who have sex with men (MSM) enrolled in two outcome studies of substance abuse treatment programs that were implementing an evidence-based, cognitive-behavioral intervention (i.e., the Matrix Model) from a harm reduction perspective. Study 1 (N = 123) examined changes in self-reported substance use, Addiction Severity Index (ASI) composite scores, and HIV care indicators over a 12-month follow-up...
June 2014: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Lukas Rambousek, Petr Kacer, Kamila Syslova, Jakub Bumba, Vera Bubenikova-Valesova, Romana Slamberova
BACKGROUND: Methamphetamine (METH) abuse is a growing health problem worldwide, and METH use during pregnancy not only endangers the mother's health but also the developing fetus. To provide better insight into these risks, we performed the following experiments. METHOD: First, we investigated how sex influences the pharmacokinetics of METH and amphetamine (AMP) in male and female rats. Subsequently, we simulated chronic exposure of prenatal infants to METH abuse by investigating brain and plasma levels of METH and AMP in dams and pups...
June 1, 2014: Drug and Alcohol Dependence
Danya Fast, Thomas Kerr, Evan Wood, Will Small
Transitions into more harmful forms of illicit drug use among youth have been identified as important foci for research and intervention. In settings around the world, the transition to crystal methamphetamine (meth) use among youth is considered a particularly dangerous and growing problem. Epidemiological evidence suggests that, particularly among young, street-involved populations, meth use is associated with numerous sex- and drug-related "risks behaviors" and negative health outcomes. Relatively few studies, however, have documented how youth themselves understand, experience and script meth use over time...
June 2014: Social Science & Medicine
Damian G Zuloaga, Lance A Johnson, Maayan Agam, Jacob Raber
Dysregulation of hypothalamic-pituitary-adrenal (HPA) axis activation is associated with changes in addiction-related behaviors. In this study, we tested whether sex differences in the acute effects of methamphetamine (MA) exposure involve differential activation of the HPA axis. Male and female mice were injected with MA (1 mg/kg) or saline for comparison of plasma corticosterone and analysis of the immediate early gene c-Fos in brain. There was a prolonged elevation in corticosterone levels in female compared to male mice...
May 2014: Journal of Neurochemistry
Shaolin Yang, Annabelle M Belcher, Svetlana Chefer, D Bruce Vaupel, Charles W Schindler, Elliot A Stein, Yihong Yang
(1) H magnetic resonance spectroscopy has demonstrated alterations in several neurometabolites in methamphetamine (METH)-dependent individuals in brain regions implicated in addiction. Yet, it is unclear whether these neurochemicals return to homeostatic levels after an individual abstains from drug use, a difficult question to address due to high recidivism and poor study retention in human subjects. We thus utilized a non-human primate model of addiction to explore the effects of long-term drug exposure and withdrawal on brain neurochemistry...
January 2015: Addiction Biology
Brittney M Cox, Amy B Young, Ronald E See, Carmela M Reichel
Previous evidence in an animal model of drug self-administration and drug seeking showed that acute oxytocin decreased methamphetamine (meth) seeking in male rats, suggesting potential clinical efficacy for the treatment of psychostimulant addiction. However, based on the well-established role of oxytocin in reproduction and pair bond formation, it is important to know how this effect extrapolates to females. Here, we tested whether oxytocin (1mg/kg, IP) would decrease meth seeking in female rats across various stages of the estrous cycle (Experiment 1)...
October 2013: Psychoneuroendocrinology
S A Lloyd, C Oltean, H Pass, B Phillips, K Staton, C L Robertson, R A Shanks
Given the widespread use and misuse of methamphetamine (METH) and methylphenidate (MPD), especially in relation to women of childbearing age, it is important to consider the long-lasting effects of these drugs on the brain of the developing fetus. Male and female C57Bl/6J mice were prenatally exposed to METH (5mg/kg), MPD (10mg/kg), or saline. Following a 3-month washout, behavioral analysis using the 5-Choice Serial Reaction Time Task (5CSRTT) was performed on adult mice. After reaching training criteria, performance on a pseudo-random intertrial interval test session revealed decrements in 5CSRTT behavior...
July 2, 2013: Physiology & Behavior
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