Yan Qin, Qingqing Liu, Saiying Wang, Qinhui Wang, Yaya Du, Jingyue Yao, Yue Chen, Qi Yang, Yumei Wu, Shuibing Liu, Minggao Zhao, Gaofei Wei, Le Yang
Chronic pain is a complex disease. It seriously affects patients' quality of life and imposes a significant economic burden on society. Santacruzamate A (SCA) is a natural product isolated from marine cyanobacteria in Panama. In this study, we first demonstrated that SCA could alleviate chronic inflammatory pain, pain-related anxiety, and depression emotions induced by complete Freund's adjuvant in mice while inhibiting microglial activation in the anterior cingulate cortex. Moreover, SCA treatment attenuated lipopolysaccharide (LPS)-induced inflammatory response by downregulating interleukin 1β and 6 (IL-1β and IL-6) and tumor necrosis factor-α (TNF-α) levels in BV2 cells...
April 12, 2024: ACS Pharmacology & Translational Science