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https://www.readbyqxmd.com/read/28449569/baclofen-abuse-due-to-its-hypomanic-effect-in-patients-with-alcohol-dependence-and-comorbid-major-depressive-disorder
#1
Soumitra Ghosh, Dhrubajyoti Bhuyan
Baclofen is a gamma-aminobutyric acid type B receptor agonist used as an anti-craving agent for treatment of alcohol dependence. It has gained popularity in the recent times because it is well tolerated even in patients with hepatic impairments. Herein we are summarizing the latest literature about baclofen induced hypomania and are reporting a case of baclofen abuse because of its mood elevating property in a patient of alcohol dependence with comorbid major depressive disorder. Literature review and case study of a 36-year-old male with alcohol dependence with comorbid major depressive disorder was prescribed with tablet baclofen as an anti-craving agent along with antidepressant medicines...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449567/dose-dependent-course-of-hyperprolactinemic-and-normoprolactinemic-galactorrhea-induced-by-venlafaxine
#2
Mehmet Akif Camkurt, Gizem Gülpamuk, Ebru Fındiklı, Rengin Elve
Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after starting treatment with venlafaxine. In particular, we discuss the course of hyper and normoprolactinemic galactorrhea. We managed this side effect initially by dose reduction and further by switching to essitalopram. Physicians should be aware of endocrinologic side effects such as galactorrhea during the serotonin and noradrenaline reuptake inhibitor treatment...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449559/effects-of-escitalopram-on-anxiety-in-patients-with-acute-coronary-syndrome-a-randomized-controlled-trial
#3
Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Jin-Sang Yoon, Jae-Min Kim
Objective: There are no evidence-based practices for treating anxiety in patients with acute coronary syndrome (ACS). Thus, we investigated the effects of escitalopram on anxiety in this population. Methods: We enrolled 217 patients with ACS who met Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for depressive disorders into a randomized double-blind placebo-controlled study. Patients received either escitalopram or placebo over a 24-week period...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449303/brief-intervention-physical-exercise-and-cognitive-behavioural-group-therapy-for-patients-with-chronic-low-back-pain-the-cins-trial
#4
A Harris, T F Moe, H R Eriksen, T Tangen, S A Lie, T H Tveito, S E Reme
BACKGROUND AND OBJECTIVE: Cognitive-behavioural treatments (CBT) and physical group exercise (PE) have both shown promising effects in reducing disability and increasing work participation among chronic low back pain (CLBP) patients. A brief cognitive intervention (BI) has previously been demonstrated to reduce work disability in CLBP. The aim of this study was to test if the effect of BI could be further increased by adding either group CBT or group PE. METHODS: A total of 214 patients, all sick listed 2-10 months due to CLBP, were randomized to BI (n = 99), BI + group CBT (n = 55) or BI + group PE (n = 60)...
April 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28448702/ketamine-for-depression-1-clinical-summary-of-issues-related-to-efficacy-adverse-effects-and-mechanism-of-action
#5
Chittaranjan Andrade
Ketamine is an anesthetic drug that is also used for off-label indications such as the mediation of analgesia and sedation in various settings. It is additionally recognized as an agent with antidepressant potential. For depression, it is most commonly administered as a slow intravenous infusion in subanesthetic doses (usually 0.5 mg/kg). As an antidepressant, is strikingly different from conventional antidepressant drugs in that it brings about rapid and marked attenuation of depressive symptoms even in patients with refractory depression...
April 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28448602/clinical-presentation-and-management-of-stable-coronary-artery-disease-in-austria
#6
Otto Pichlhöfer, Manfred Maier, Roza Badr-Eslam, Robin Ristl, Magdalena Zebrowska, Irene M Lang
BACKGROUND: Cardiovascular disease is the main cause of death in Austria. However, no systematic information exists regarding characteristics and treatments of contemporary patients with stable coronary artery disease (CAD) in Austria. We assembled two retrospective physicians' databases to describe demographics, clinical profiles, and therapeutic strategies in patients with stable CAD. In addition, we compared patient profiles of secondary care internists and hospital-based cardiologists with those of general practitioners in a primary care setting outside of hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28448178/what-is-being-measured-a-comparison-of-two-depressive-symptom-severity-instruments-with-a-depression-diagnosis-in-low-income-high-risk-mothers
#7
Jenny Yang, Maria Martinez, Todd A Schwartz, Linda Beeber
BACKGROUND: Adequate assessment of depressive symptomatology is a necessary step toward decreasing income-related mental health treatment inequity. No studies have focused on comparing instruments used to detect depression in women from low-income backgrounds who are mothers of young children-a period of increased risk for depressive symptoms. METHODS: To address this gap, two commonly used instruments (Center for Epidemiologic Studies Depression Scale [CES-D] and Hamilton Rating Scale for Depression [Hamilton]) were compared with a depression diagnosis (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [DSM-V]) in a sample (n = 251) of mothers from low-income backgrounds with children ranging from 1 to 54 months old...
April 27, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28447807/developing-a-measure-to-assess-identity-reconstruction-in-patients-with-multiple-sclerosis
#8
Lara M Stepleman, Rebecca M Floyd, Abbey Valvano-Kelley, Lauren Penwell-Waines, Sarah Wonn, Danielle Crethers, Rebecca Rahn, Suzanne Smith
PURPOSE/OBJECTIVE: To develop and test initial validation of a theory-driven quantitative measure of identity reconstruction in patients with multiple sclerosis (MS) based upon previous qualitative research. Research Method/Design: This study uses a cross-sectional survey design, in which 137 patients living with MS were recruited from an outpatient MS Center in the Southeastern U.S. Participants completed demographic items, Identity Reconstruction Assessment Scales (IRAS), Patient Determined Disease Steps, Medical Outcomes Study Measures of Patient Adherence, Chronic Disease Self-Efficacy Scale, Hospital Anxiety and Depression Scale, Leeds MS Quality of Life Questionnaire, MS-Related Stigma Scale, and Posttraumatic Growth Inventory-Short Form...
April 27, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28447806/blame-coping-and-psychosocial-outcomes-in-caregivers-of-individuals-with-brain-injury
#9
Samantha DeDios-Stern, Eun-Jeong Lee
OBJECTIVE: Acquired brain injury (ABI) is associated with many physical and psychiatric conditions. Oftentimes, the individual's family members are responsible for providing long-term care, leaving caregivers vulnerable to negative effects of caregiving including stress, depression, and decreased quality of life. Attribution theory suggests that caregivers may blame the individual with the ABI for their injury as a way to understand their own circumstances. The objective of this study was to investigate caregiver coping strategies as possible mediators between caregiver family member blame and caregiver psychosocial outcomes among caregivers of individuals with ABI...
April 27, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28447757/molecular-mechanism-of-smurf2-in-regulating-the-expression-of-snon-in-diabetic-nephropathy
#10
Zhuojia Xu, Zongli Diao, Ruixia Liu, Wenhu Liu
The aim of the present study was to examine the regulatory mechanism underlying the depression in Ski‑related novel protein N (SnoN) in diabetic nephrology (DN). NRK‑52E cells, a rat primary renal tubular epithelial cell line, were cultured to clarify the effect of small mothers against decapentaplegic (Smad) ubiquitination regulatory factor 2 (smurf2) on SnoN in a low glucose environment in vitro. NRK‑52E cells and DM rats were injected with adenoviruses AD‑smurf2 and AD‑shsmurf2, respectively, and the protein expression profiles of SnoN, smurf2 and phosphorylated (p)‑Smad2 were then detected...
March 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447567/a-longitudinal-assessment-of-psychological-distress-after-oesophageal-cancer-surgery
#11
Ylva Hellstadius, Jesper Lagergren, Janine Zylstra, James Gossage, Andrew Davies, Christina M Hultman, Pernilla Lagergren, Anna Wikman
BACKGROUND: Psychological distress is common among patients with oesophageal cancer. However, little is known about the course and predictors of psychological distress among patients treated with curative intent. Therefore, the aim of this study was to explore the prevalence, course and predictors of anxiety and depression in patients operated for oesophageal cancer, from prior to surgery to 12 months post-operatively. METHODS: A prospective cohort of patients with oesophageal cancer (n = 218) were recruited from one high-volume specialist oesophago-gastric treatment centre (St Thomas' Hospital, London, UK)...
May 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28447566/pain-sensory-disturbances-and-psychological-distress-are-common-sequelae-after-treatment-of-ductal-carcinoma-in-situ-a-cross-sectional-study
#12
Birgitte Goldschmidt Mertz, Helle Molter Duriaud, Niels Kroman, Kenneth Geving Andersen
Sequelae such as pain, sensory disturbances and psychological distress are well known after treatment for invasive breast cancer (IBC). Patients treated for ductal carcinoma in situ (DCIS) receive a similar treatment as low-risk IBC. The aim of this cross-sectional study was to describe prevalence of postoperative pain, sensory disturbances, psychological distress and rehabilitation needs among Danish women with DCIS. METHODS: A total of 574 women treated for DCIS in Denmark in 2013 and 2014 were enrolled and 473 (82%) completed a detailed questionnaire on demographic factors, pain, sensory disturbances, psychological aspects and rehabilitation needs 1-3 years after surgery...
May 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28447499/is-pre-implantation-genetic-diagnosis-pgd-more-of-a-strain-regarding-satisfaction-with-marital-quality-for-male-or-female-partners-a-three-year-follow-up-study
#13
Stina Järvholm, Ann Thurin-Kjellberg, Malin Broberg
INTRODUCTION: Men and women with a hereditary genetic disease are faced with different options when they plan to become parents. One is pre-implantation genetic diagnosis (PGD) which is a combination of in vitro fertilization (IVF) and genetic analysis of the embryo before implantation. The present study focuses on how men and women planning for PGD experience the quality of marital satisfaction when they apply for treatment and again, three years later. METHODS: The study was a prospective cohort study where all couples (n = 22) applying for PGD during 2010 and 2011 were eligible...
April 27, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28447227/the-efficacy-of-serratus-anterior-plane-block-in-analgesia-for-thoracotomy-a-retrospective-study
#14
Korgün Ökmen, Burcu Metin Ökmen
PURPOSE: A multimodal analgesic approach is necessary for post-thoracotomy pain, which can be severe. Intravenous access, central and peripheral nerve blocks are frequently used. The aim of this study was to evaluate the efficacy of serratus anterior plane block (SAPB) in the management of post-thoracotomy pain. METHODS: A total of 40 patients who underwent thoracotomy between January 2014 and January 2016 were retrospectively analyzed. The patients were divided into two groups: Group M (intravenous patient-controlled analgesia morphine; n = 20) and Group S (intravenous patient-controlled analgesia morphine + SAPB; n = 20)...
April 26, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28447101/development-and-use-of-a-clinical-decision-support-tool-for-behavioral-health-screening-in-primary-care-clinics
#15
Timothy E Burdick, Rodger S Kessler
OBJECTIVE: Screening, brief intervention, and referral for treatment (SBIRT) for behavioral health (BH) is a key clinical process. SBIRT tools in electronic health records (EHR) are infrequent and rarely studied. Our goals were 1) to design and implement SBIRT using clinical decision support (CDS) in a commercial EHR; and 2) to conduct a pragmatic evaluation of the impact of the tools on clinical outcomes. METHODS: A multidisciplinary team designed SBIRT workflows and CDS tools...
April 26, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28446646/randomized-controlled-trial-of-deutetrabenazine-for-tardive-dyskinesia-the-arm-td-study
#16
Hubert H Fernandez, Stewart A Factor, Robert A Hauser, Joohi Jimenez-Shahed, William G Ondo, L Fredrik Jarskog, Herbert Y Meltzer, Scott W Woods, Danny Bega, Mark S LeDoux, David R Shprecher, Charles Davis, Mat D Davis, David Stamler, Karen E Anderson
OBJECTIVE: To determine the efficacy and safety of deutetrabenazine as a treatment for tardive dyskinesia (TD). METHODS: One hundred seventeen patients with moderate to severe TD received deutetrabenazine or placebo in this randomized, double-blind, multicenter trial. Eligibility criteria included an Abnormal Involuntary Movement Scale (AIMS) score of ≥6 assessed by blinded central video rating, stable psychiatric illness, and stable psychoactive medication treatment...
April 26, 2017: Neurology
https://www.readbyqxmd.com/read/28446525/effectiveness-of-befriending-interventions-a-systematic-review-and-meta-analysis
#17
Joyce Siette, Megan Cassidy, Stefan Priebe
OBJECTIVE: Befriending is an emotional supportive relationship in which one-to-one companionship is provided on a regular basis by a volunteer. It is commonly and increasingly offered by the voluntary sector for individuals with distressing physical and mental conditions. However, the effectiveness of this intervention on health outcomes is largely unknown. We aim to conduct a systematic review of the benefits of befriending. DESIGN: Systematic review. METHODS: A systematic search of electronic databases was conducted to identify randomised controlled trials and quasi-experimental trials of befriending for a range of physical and mental health indications including depression, anxiety, mental illness, cancer, physical illness and dementia...
April 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28446141/a-mobile-application-of-breast-cancer-e-support-program-versus-routine-care-in-the-treatment-of-chinese-women-with-breast-cancer-undergoing-chemotherapy-study-protocol-for-a-randomized-controlled-trial
#18
Jiemin Zhu, Lyn Ebert, Xiangyu Liu, Sally Wai-Chi Chan
BACKGROUND: Women with breast cancer undergoing chemotherapy suffer from a number of symptoms and report receiving inadequate support from health care professionals. Innovative and easily accessible interventions are lacking. Breast Cancer e-Support is a mobile Application program (App) that provides patients with individually tailored information and a support group of peers and health care professionals. Breast Cancer e-Support aims to promote women's self-efficacy, social support and symptom management, thus improving their quality of life and psychological well-being...
April 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28445899/evidence-based-guidelines-for-the-pharmacologic-management-of-methamphetamine-dependence-relapse-prevention-chronic-methamphetamine-related-and-comorbid-psychiatric-disorders-in-post-acute-settings
#19
Roland Härtel-Petri, Anne Krampe-Scheidler, Wolf-Dietrich Braunwarth, Ursula Havemann-Reinecke, Peter Jeschke, Winfried Looser, Stephan Mühlig, Ingo Schäfer, Norbert Scherbaum, Lydia Bothe, Corinna Schaefer, Willem Hamdorf
The increasing abuse of the street drug crystal meth (methamphetamine) in many countries worldwide has resulted in a growing demand to treat patients who have acquired a methamphetamine-related disorder. The results of a systematic literature search which led to the consensus-based recommendations by the Working Group of the German Agency for Quality in Medicine (Ärztliches Zentrum für Qualität in der Medizin - ÄZQ) are presented. Pharmacological treatments were reviewed in 58 out of the 103 publications included...
April 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28445888/differential-effects-of-inflammatory-and-psychosocial-stress-on-mood-hypothalamic-pituitary-adrenal-axis-and-inflammation-in-remitted-depression
#20
Peter Niemegeers, Peter De Boer, Glenn J H Dumont, Filip Van Den Eede, Erik Fransen, Stephan J Claes, Manuel Morrens, Bernard G C Sabbe
BACKGROUND/AIMS: Major depressive disorder (MDD) is highly recurrent. This may be due to increased stress sensitivity after remission. Both inflammatory and psychosocial stressors are implicated in the pathogenesis of MDD, but the additive or differential effect is unclear. METHODS: We conducted a single-blind placebo-controlled study to investigate the effects of inflammatory stress (i.e., typhoid vaccination), psychosocial stress (i.e., Trier Social Stress Test [TSST]), or a combination of both in women (25-45 years old) with (partially) remitted recurrent MDD (n = 21) and healthy female controls (n = 18)...
April 27, 2017: Neuropsychobiology
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