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https://www.readbyqxmd.com/read/28630283/molecular-behavioral-and-physiological-consequences-methamphetamine-neurotoxicity-implications-for-treatment
#1
Anna Moszczynska, Sean P Callan
Understanding the relationship between the molecular mechanisms underlying neurotoxicity of high-dose methamphetamine (METH) and related clinical manifestations is imperative for providing more effective treatments for human METH users. This article provides overview of neurobiology underlying consequences of administration of neurotoxic METH doses.
June 19, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28621212/methamphetamine-causes-neurotoxicity-by-promoting-polarization-of-macrophages-and-inflammatory-response
#2
X Li, F Wu, L Xue, B Wang, J Li, Y Chen, T Chen
Macrophages, especially their activation state, are closely related to the progression of neurotoxicity. Classically activated macrophages (M1) are proinflammatory effectors, while alternatively activated macrophages (M2) exhibit anti-inflammatory properties. As a powerful addictive psychostimulant drug, coupled with its neurotoxicity, methamphetamine (Meth) abuse may lead to long-lasting abnormalities in the neuronal system. The present study investigated the effect of Meth at subtoxic concentration on macrophage activation state and its underlying toxicity to neuronal cells...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28619521/overview-of-long-non-coding-rna-and-mrna-expression-in-response-to-methamphetamine-treatment-in-vitro
#3
Kun Xiong, Lingling Long, Xudong Zhang, Hongke Qu, Haixiao Deng, Yanjun Ding, Jifeng Cai, Shuchao Wang, Mi Wang, Lvshuang Liao, Jufang Huang, Chunxia Yi, Jie Yan
Long non-coding RNAs (lncRNAs) display multiple functions including regulation of neuronal injury. However, their impact in methamphetamine (METH)-induced neurotoxicity has rarely been reported. Here, using microarray analysis, we investigated the expression profiling of lncRNAs and mRNAs in primary cultured prefrontal cortical neurons after METH treatment. We observed a difference in lncRNA and mRNA expression between the experimental and sham control groups. Using bioinformatics, we analyzed the highest enriched gene ontology (GO) terms of biological process, cellular component, and molecular function, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and pathway network analysis...
June 12, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28612212/risk-behaviors-for-hiv-and-hcv-infection-among-people-who-inject-drugs-in-hai-phong-viet-nam-2014
#4
Huong Thi Duong, Don Des Jarlais, Oanh Hai Thi Khuat, Kamyar Arasteh, Jonathan Feelemyer, Pham Minh Khue, Hoang Thi Giang, Didier Laureillard, Vinh Vu Hai, Roselyne Vallo, Laurent Michel, Jean Pierre Moles, Nicolas Nagot
We examined the potential for HIV and hepatitis C (HCV) transmission across persons who inject drugs (PWID), men-who-have-sex-with-men (MSM) and female commercial sex workers (CSW) PWID and the potential for sexual transmission of HIV from PWID to the general population in Hai Phong, Viet Nam. Using respondent driven and convenience sampling we recruited 603 participants in 2014. All participants used heroin; 24% used non-injected methamphetamine. HIV prevalence was 25%; HCV prevalence was 67%. HIV infection was associated with HCV prevalence and both infections were associated with length of injecting career...
June 13, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28608786/new-human-immunodeficiency-virus-diagnosis-independently-associated-with-rectal-gonorrhea-and-chlamydia-in-men-who-have-sex-with-men
#5
Lindley A Barbee, Christine M Khosropour, Julia C Dombrowksi, Matthew R Golden
BACKGROUND: Rectal sexually transmitted infections (STI) have been associated with human immunodeficiency virus (HIV) diagnosis, but inferring a causal association requires disentangling them from receptive anal intercourse (RAI). METHODS: We conducted a stratified case-control study by frequency matching 4 controls to each case within year using clinical data from men who have sex with men (MSM) attending the Seattle STD Clinic 2001 to 2014. Cases were MSM with a new HIV diagnosis and negative HIV test at 12 months or less...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28597397/protein-kinase-c%C3%AE-gene-depletion-protects-against-methamphetamine-induced-impairments-in-recognition-memory-and-erk1-2-signaling-via-upregulation-of-glutathione-peroxidase-1-gene
#6
The-Vinh Tran, Eun-Joo Shin, Lan Thuy Ty Nguyen, Youngho Lee, Dae-Joong Kim, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Kazuya Toriumi, Toshitaka Nabeshima, Kiyofumi Yamada, Hyoung-Chun Kim
Accumulating evidence has suggested that repeated treatment with methamphetamine (MA) resulted in cognitive impairments. Importantly, we show that selective upregulation of protein kinase Cδ (PKCδ) in the prefrontal cortex (PFC) of wild-type mice persisted for 28 days post withdrawal of MA. On day 28, the MA-induced increase in phospho-PKCδ expression and decrease in phospho-ERK1/2 expression were significantly attenuated by both the Src inhibitor PP2 and the dopamine D1 receptor antagonist SCH 23390. However, neither protein kinase A inhibitor H89 nor calmodulin-dependent protein kinase II inhibitor KN93 attenuated MA-induced alterations in phospho-PKCδ expression and phospho-ERK1/2 expression...
June 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28589263/assessment-of-tolerance-to-the-effects-of-methamphetamine-on-daytime-and-nighttime-activity-evaluated-with-actigraphy-in-rhesus-monkeys
#7
Laís F Berro, Monica L Andersen, Leonard L Howell
RATIONALE: Methamphetamine is one of the most largely consumed illicit drugs, and its use is associated with abuse liability and several adverse health effects, such as sleep impairment. Importantly, sleep quality can influence addiction treatment outcomes. Evidence suggests that tolerance can develop to the sleep-disrupting effects of stimulant drugs. OBJECTIVE: The aim of the present study was to investigate the development of tolerance to the actigraphy-based sleep-disrupting and stimulant effects of methamphetamine self-administration in rhesus monkeys...
June 7, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28587620/comparing-the-effect-of-buprenorphine-and-methadone-in-the-reduction-of-methamphetamine-craving-a-randomized-clinical-trial
#8
Jamshid Ahmadi, Leila Razeghian Jahromi
BACKGROUND: We sought to test the effectiveness of methadone and buprenorphine in the treatment of methamphetamine withdrawal craving over a 17-day treatment period. METHODS: Patients were randomized into one of two groups. The study sample comprised 40 male subjects dependent on methamphetamine who met criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, for methamphetamine dependence and withdrawal and were seeking treatment. Furthermore, they should have a history of daily methamphetamine use for at least 6 months and should have discontinued their use just before starting the protocol...
June 6, 2017: Trials
https://www.readbyqxmd.com/read/28583866/effects-of-chronic-cocaine-morphine-and-methamphetamine-on-the-mobility-immobility-and-stereotyped-behaviors-in-crayfish
#9
Adebobola Imeh-Nathaniel, Natalia Rincon, Vasiliki Bessie Orfanakos, Leanne Brechtel, Leah Wormack, Erika Richardson, Robert Huber, Thomas I Nathaniel
The worth of crayfish as a model system for studies of addiction was not previously recognized because a drug-reward phenomenon had not been documented in this model system. In our previous experiments, we demonstrate that the crayfish natural reward pathways are sensitive to human drugs of abuse. This finding supports crayfish as a suitable model to characterize specific behaviors that are relevant in drug addiction research, and the current study builds on our previous findings. The aim of the present study was to investigate unconditioned neurobehavioral effects of repeated treatment regimens using cocaine, morphine, and methamphetamine for three consecutive days...
June 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28583136/social-structural-factors-influencing-periods-of-injection-cessation-among-marginalized-youth-who-inject-drugs-in-vancouver-canada-an-ethno-epidemiological-study
#10
Jade Boyd, Danya Fast, Megan Hobbins, Ryan McNeil, Will Small
BACKGROUND: Injection drug use is associated with HIV and hepatitis C transmission, overdose, and other preventable harms. These harms are heightened for structurally vulnerable injection drug-using populations, as their social conditions pose barriers to safer injecting. Previous research on injection cessation has largely focused on adult drug-using populations. Little qualitative work has examined the social, structural, and environmental factors that shape periods of injection cessation among youth and young adults...
June 5, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28579325/a-peptide-disrupting-the-d2r-dat-interaction-protects-against-dopamine-neurotoxicity
#11
Ping Su, Fang Liu
Dopamine reuptake from extracellular space to cytosol leads to accumulation of dopamine, which triggers neurotoxicity in dopaminergic neurons. Previous studies have shown that both dopamine D2 receptor (D2R) and dopamine transporter (DAT) are involved in dopamine neurotoxicity. However, blockade of either D2R or DAT causes side effects due to antagonism of other physiological functions of these two proteins. We previously found that DAT can form a protein complex with D2R and its cell surface expression is facilitated via D2R-DAT interaction, which regulates dopamine reuptake and intracellular dopamine levels...
June 1, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28578516/risk-perception-sexual-behaviors-and-prep-adherence-among-substance-using-men-who-have-sex-with-men-a-qualitative-study
#12
Erik D Storholm, Jonathan E Volk, Julia L Marcus, Michael J Silverberg, Derek D Satre
The antiretroviral drug combination emtricitabine and tenofovir disoproxil fumarate (TDF/FTC) taken as pre-exposure prophylaxis (PrEP) is effective in preventing HIV infection, yet it also requires adherence and potentially decreases condom use. This study sought to examine these issues among a key population at risk of HIV infection, substance-using men who have sex with men (MSM). We conducted semi-structured interviews with an ethnically diverse sample of 30 young (aged 20-35) MSM prescribed PrEP within a large integrated healthcare system in San Francisco, who had reported recent drug use or hazardous drinking and one or more missed doses of PrEP...
June 3, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28573080/rapid-identification-of-psychoactive-drugs-in-drained-gastric-lavage-fluid-and-whole-blood-specimens-of-drug-overdose-patients-using-ambient-mass-spectrometry
#13
Chi-Wei Lee, Hung Su, You-Da Cai, Ming-Tsang Wu, Den-Chyang Wu, Jentaie Shiea
Psychoactive drug overdoses are life-threatening and require prompt and proper treatment in the emergency room to minimize morbidity and mortality. Prompt identification of the ingested psychoactive drugs is challenging, since witness recall is unreliable and patients' symptoms do not necessarily explain their loss of consciousness. Gas and liquid chromatography mass spectrometric analyses have been the traditionally employed methods to detect and identify abused substances; however, these techniques are time-consuming and labor-intensive...
2017: Mass Spectrometry
https://www.readbyqxmd.com/read/28561211/-increasing-consumption-of-crystal-meth-in-saxony-and-its-risks-for-mother-and-child-experiences-at-a-level-i-perinatal-center-from-a-pediatric-viewpoint
#14
Jürgen Dinger, Nicole Näther, Pauline Wimberger, Ulrich S Zimmermann, Jochen Schmitt, Jörg Reichert, Mario Rüdiger
Over the past several years, the number of first-time users of methamphetamine considerably increased within the Free State of Saxony. This number also, and especially, includes women of child-bearing age and young mothers. A supportive intervention aimed at reducing the effects of drug abuse should begin in a timely way - during pregnancy at latest, but better before it. To develop an optimal care protocol for both the mother and her child, more knowledge regarding the personal conditions of the women as well as the specific features of later child development after prenatal methamphetamine exposure (PME) is vital...
April 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28560628/fate-of-selected-drugs-in-the-wastewater-treatment-plants-wwtps-for-domestic-sewage
#15
Agostina Chiavola, Pierpaolo Tedesco, Maria Rosaria Boni
The wide diffusion of Emerging Organic Micropollutants (EOMs) in the environment is receiving increasing attention due to their potential toxicological effects on living organisms. So far, the Wastewater Treatment Plants (WWTPs) have not been designed with the purpose to remove these contaminants; therefore, they can represent the major source of release into the environment both through the effluent and the wasted sludge. The fate of EOMs in the WWTPs is still not completely known; further investigations are therefore needed to assess if it is possible to exploit the existing treatment units to reduce EOM concentrations or which processes must be implemented to this purpose...
May 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28550341/development-of-a-risk-algorithm-to-better-target-sti-testing-and-treatment-among-australian-aboriginal-and-torres-strait-islander-people
#16
Handan Wand, Joanne Bryant, Marian Pitts, Dea Delaney-Thiele, John M Kaldor, Heather Worth, James Ward
Identifying and targeting those at greatest risk will likely play a significant role in developing the most efficient and cost-effective sexually transmissible infections (STI) prevention programs. We aimed to develop a risk prediction algorithm to identify those who are at increased risk of STI. A cohort (N = 2320) of young sexually active Aboriginal and Torres Strait Islander people (hereafter referred to as Aboriginal people) were included in this study. The primary outcomes were self-reported high-risk sexual behaviors and past STI diagnosis...
May 26, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28543168/a-new-tool-to-tackle-the-opioid-epidemic-description-utility-and-results-from-the-maine-diversion-alert-program
#17
Brian J Piper, Clare E Desrosiers, Harriet C Fisher, Kenneth L McCall, Stephanie D Nichols
STUDY OBJECTIVE: The opioid epidemic continues to impact the United States, and new strategies are needed to combat this epidemic. The objective of this study was to analyze 2015 drug arrest data from Maine's Diversion Alert program (diversionalert. org), compare arrest data between the first quarters of 2015 and 2016, and provide an analysis of the sex differences in the arrests as well as information about DA use. STUDY DESIGN: A population-based, descriptive study using data from the Maine Diversion Alert Program...
May 19, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28531769/increases-in-prescription-opioid-injection-abuse-among-treatment-admissions-in-the-united-states-2004-2013
#18
Christopher M Jones, Aleta Christensen, R Matthew Gladden
BACKGROUND: The 2015 HIV outbreak in Indiana associated with prescription opioid injection coupled with rising rates of hepatitis C, especially in areas with long-standing opioid abuse, have raised concerns about prescription opioid injection. However, research on this topic is limited. We assessed trends in treatment admissions reporting injection, smoking, and inhalation abuse of prescription opioids and examined characteristics associated with non-oral routes of prescription opioid abuse in the U...
May 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28527425/effects-of-the-summer-holiday-season-on-uv-filter-and-illicit-drug-concentrations-in-the-korean-wastewater-system-and-aquatic-environment
#19
Ki Yong Kim, Kalu Ibe Ekpeghere, Hee-Jin Jeong, Jeong-Eun Oh
Seasonal variations in the concentrations of eight ultraviolet (UV) filters and 22 illicit drugs including their metabolites in the Korean aquatic environment were investigated. Seawater samples from three beaches, water samples from two rivers, and influents and effluents from three wastewater treatment plants were analyzed. The UV filter concentrations in the seawater, river water, and effluent samples were 39.4-296, 35.4-117, and 6.84-51.1 ng L(-1), respectively. The total UV filter concentrations in the seawater samples were 1...
August 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28511099/the-social-exigencies-of-the-gateway-progression-to-the-use-of-illicit-drugs-from-adolescence-into-adulthood
#20
Roy Otten, Chung Jung Mun, Thomas J Dishion
BACKGROUND: There is limited empirical integration between peer clustering theory and the Gateway framework. The goal of the present study was to test the hypothesis that friendship associations partly predict gateway escalations in the use of drugs from adolescence to adulthood. METHOD: This longitudinal study analyzed 3 waves of data from a community sample of 711 male and female participants without a history of illicit drug use reporting drug use at age 17, 22, and 27...
May 11, 2017: Addictive Behaviors
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