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https://www.readbyqxmd.com/read/29465666/characteristics-associated-with-delivery-of-an-infant-with-congenital-syphilis-and-missed-opportunities-for-prevention-california-2012-2014
#1
Hope H Biswas, Rilene A Chew Ng, Erin L Murray, Joan M Chow, Juliet E Stoltey, James P Watt, Heidi M Bauer
BACKGROUND: Congenital syphilis (CS), the transmission of Treponema pallidum from mother to fetus during pregnancy, can cause adverse birth outcomes. During 2012-2014, the CS rate in California increased >200% from 6.6 to 20.3 cases per 100,000 live births. Our objectives were to identify characteristics associated with delivering an infant with CS and missed opportunities for prevention among syphilis-infected pregnant women in California. METHODS: We linked California Department of Public Health syphilis surveillance records from women aged 15-45 years - diagnosed during March 13, 2012-December 31, 2014 - to birth records...
January 4, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29461948/case-251-nontraumatic-drug-associated-rhabdomyolysis-of-head-and-neck-muscles
#2
Alexandre Debelmas, Déborah Benchetrit, Damien Galanaud, Roman H Khonsari
History A 21-year-old man with a history of abuse of multiple drugs and mild cognitive impairment who initially underwent treatment for excited delirium developed respiratory arrest shortly after admission and was successfully resuscitated. Unenhanced computed tomography (CT) of the head and neck and contrast material-enhanced CT of the chest, abdomen, pelvis, and complete spine were performed shortly after the initial treatment. Head and neck magnetic resonance (MR) imaging was performed 24 hours after admission...
March 2018: Radiology
https://www.readbyqxmd.com/read/29457009/acneiform-rash-caused-by-an-unlikely-drug-topiramate
#3
Yesenia Bello-Hernández, Jessica Espinoza-Hernández, Gabriela Moreno-Coutiño
Topiramate is an antiepileptic drug that can also be used for migraine prophylaxis, weight control, and even for methamphetamine dependence; the dosage margin is wide, and the list of side effects is shorter than with other anticonvulsants. We present the case of a 35-year-old man with a disseminated rash of the trunk and extremities after treatment with 25 mg of topiramate daily as a prophylactic migraine treatment. This case report is useful, as this patient was not polymedicated and had a score of 7 on the Naranjo Adverse Drug Reaction Probability Scale...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29453037/profile-of-psychiatric-symptoms-in-methamphetamine-users-in-china-greater-risk-of-psychiatric-symptoms-with-a-longer-duration-of-use
#4
Jun Ma, Xin-Jun Sun, Ru-Jia Wang, Tong-Yu Wang, Meng-Fan Su, Mo-Xuan Liu, Su-Xia Li, Ying Han, Shi-Qiu Meng, Ping Wu, Jie Shi, Yan-Ping Bao, Lin Lu
Chronic methamphetamine (MA) use is associated with psychiatric symptoms. This study explored pattern of co-occurring psychiatric symptoms in MA users and their relationship to duration of MA use. A cross-sectional study was conducted among MA users at the Shenzhen Compulsory Drug Detoxification Center from April 2012 to October 2015. The Positive and Negative Syndrome Scale, Hamilton Anxiety Scale, and Beck Depression Inventory were used to assess psychiatric symptoms. Among 1277 MA users, 57.6% participants had any type of psychiatric symptoms including depressive, anxiety and psychotic symptoms...
February 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29452175/replacement-treatment-during-extinction-training-with-the-atypical-dopamine-uptake-inhibitor-jhw-007-reduces-relapse-to-methamphetamine-seeking
#5
Ashlea F Dassanayake, Juan J Canales
There are currently no approved medications to effectively counteract the effects of methamphetamine (METH), reduce its abuse and prolong abstinence from it. Data accumulated in recent years have shown that a range of N-substituted benztropine (BZT) analogues possesses psychopharmacological features consistent with those of a potential replacement or "substitute" treatment for stimulant addiction. On the other hand, the evidence that antidepressant therapy may effectively prevent relapse to stimulant seeking is controversial...
February 13, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29452065/past-year-nonmedical-use-of-prescription-drugs-among-women-on-probation-and-parole-a-cross-sectional-study
#6
Martin T Hall, Diana Ball, Jeanelle Sears, George E Higgins, T K Logan, Seana Golder
BACKGROUND: Prescription drug-related overdose deaths have increased dramatically in recent years. Women in the justice system experience high rates of drug use, victimization, trauma symptoms, and other health problems, and would appear to be at high risk for nonmedical use of prescription drugs (NMUPD). This study will be among the first to describe prevalence and correlates of NMUPD among this population. METHODS: This cross-sectional study collected data from 406 victimized women on probation and parole between 2010 and 2012...
February 16, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29447954/the-inhibitory-effect-of-levo-tetrahydropalmatine-on-the-methamphetamine-induced-spatial-memory-impairment-in-mice
#7
Guofen Cao, Yongai Zhang, Li Zhu, Jie Zhu, Na Zhao, Nan Dong, Yonghui Dang, Yanjiong Chen, Teng Chen
Methamphetamine (METH) administration results in addiction and memory impairment. Previous studies have suggested that levo-tetrahydropalmatine (l-THP), an alkaloid purified from the Chinese herb Corydalis, attenuates the behavioral changes induced by METH. Therefore, in this study, we explored whether l-THP could also protect against the METH-induced memory impairment examined using the Morris water maze (MWM). We found that low dose of METH (1.0 mg/kg) treated for 20 consecutive days prior to the MWM experiment impaired spatial memory retention but not acquisition in mice...
February 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29440309/the-phosphodiesterase-2a-inhibitor-tak-915-ameliorates-cognitive-impairments-and-social-withdrawal-in-n-methyl-d-aspartate-receptor-antagonist-induced-rat-models-of-schizophrenia
#8
Masato Nakashima, Haruka Imada, Eri Shiraishi, Yuki Ito, Noriko Suzuki, Maki Miyamoto, Takahiko Taniguchi, Hiroki Iwashita
The pathophysiology of schizophrenia has been associated with glutamatergic dysfunction. Modulation of the glutamatergic signaling pathway, including N-methyl-D-aspartate (NMDA) receptors, can provide a new therapeutic target for schizophrenia. Phosphodiesterase 2A (PDE2A) is highly expressed in the forebrain, and is a dual substrate enzyme that hydrolyzes both cAMP and cGMP, which play pivotal roles as intracellular second messengers downstream of NMDA receptors. Here we characterize the in vivo pharmacological profile of a selective and brain penetrant PDE2A inhibitor, (N-{(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide) (TAK-915) as a novel treatment for schizophrenia...
February 13, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29429705/synthesis-of-novel-sonocatalyst-er3-yalo3-nb2o5-and-its-application-for-sonocatalytic-degradation-of-methamphetamine-hydrochloride
#9
Chunsheng Wei, Kuiyu Yi, Guangsheng Sun, Jun Wang
The composited sonocatalyst Er3+:YAlO3/Nb2O5 was prepared by ultrasonic dispersion and high temperature calcinations method. The microstructure of Er3+:YAlO3 was prepared via sol-gel method and Nb2O5 was prepared by hydrothermal method. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDX), ultraviolet-visible (UV-vis) spectra and photoluminescence (PL) spectra, respectively. The sonocatalytic decomposition activity of composite sonocatalyst Er3+:YAlO3/Nb2O5 was investigated by using ultrasound as sound source and methamphetamine hydrochloride as the target degradation product...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29427917/hiv-treatment-optimism-and-crystal-methamphetamine-use-and-initiation-among-hiv-negative-men-who-have-sex-with-men-in-vancouver-canada-a-longitudinal-analysis
#10
Sean P Colyer, Nathan J Lachowsky, Zishan Cui, Julia Zhu, Heather L Armstrong, Matthew Taylor, Joshua Edward, Gbolahan Olarewaju, Robert S Hogg, Eric A Roth, David M Moore
BACKGROUND: Treatment as Prevention (TasP) leading to increased HIV treatment optimism among men who have sex with men (MSM) has been previously associated with behavioural risk compensation, though not yet via crystal methamphetamine (CM) use. Among HIV-negative MSM in a TasP environment, this study aimed to investigate the prevalence of recent CM use over time, examine the association between HIV treatment optimism and CM use and initiation, and identify correlates of recent CM use and predictors of CM initiation...
February 7, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29427284/a-single-high-dose-of-methamphetamine-reduces-monoamines-and-impairs-egocentric-and-allocentric-learning-and-memory-in-adult-male-rats
#11
Arnold Gutierrez, Michael T Williams, Charles V Vorhees
Methamphetamine (MA) alters dopamine markers and cognitive function in heavy users. In rodents, there are MA dosing regimens that induce concordant effects using repeated administration at spaced intervals. These regimens are effective but complicate experiments designed to disentangle the effects of the drug on different brain regions in relation to their cognitive effects because of treatment spacing. In an effort to simplify the model, we tested whether a single dose of MA could induce the same monoamine and cognitive effects as multiple, spaced dosing without affecting survival...
February 9, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29427069/new-scaffold-for-lead-compounds-to-treat-methamphetamine-use-disorders
#12
Na-Ra Lee, Guangrong Zheng, Peter A Crooks, Michael T Bardo, Linda P Dwoskin
Despite increased methamphetamine use worldwide, pharmacotherapies are not available to treat methamphetamine use disorder. The vesicular monoamine transporter-2 (VMAT2) is an important pharmacological target for discovery of treatments for methamphetamine use disorder. VMAT2 inhibition by the natural product, lobeline, reduced methamphetamine-evoked dopamine release, methamphetamine-induced hyperlocomotion, and methamphetamine self-administration in rats. Compared to lobeline, lobelane exhibited improved affinity and selectivity for VMAT2 over nicotinic acetylcholine receptors...
February 9, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29421753/occurrence-of-illicit-drugs-in-two-wastewater-treatment-plants-in-the-south-of-italy
#13
Alida Cosenza, Carmelo Massimo Maida, Donatella Piscionieri, Serena Fanara, Francesca Di Gaudio, Gaspare Viviani
In this study the occurrence and the behavior of illicit drugs and their metabolites have been investigated for two wastewater treatment plants (WWTPs) (namely, WWTP-1 and WWTP-2) located in Sicily (island of Italy). Samples were analyzed for methamphetamine, cocaine (COC), 3,4-methylenedioxymethamphetamine (MDMA), methadone (METH), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), 3,4-methylenedioxy amphetamine (MDA); 3,4-methylenedioxy ethylamphetamine (MDEA), 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) and Benzoylecgonine (BEG)...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29417763/combined-treatment-with-a-selective-pde10a-inhibitor-tak-063-and-either-haloperidol-or-olanzapine-at-subeffective-doses-produces-potent-antipsychotic-like-effects-without-affecting-plasma-prolactin-levels-and-cataleptic-responses-in-rodents
#14
Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, Clizia Capuani, Annarosa Ugolini, Mauro Corsi, Haruhide Kimura
Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with dopamine D2 receptor antagonism. TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] is a novel phosphodiesterase 10A inhibitor that activates both direct and indirect pathway MSNs through increasing both cAMP and cGMP levels by inhibition of their degradation. The activation of indirect pathway MSNs through the distinct mechanism of action of these drugs raises the possibility of augmented pharmacological effects by combination therapy...
February 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29415855/utilization-of-outpatient-medical-care-and-substance-use-among-rural-stimulant-users-do-the-number-of-visits-matter
#15
Michael A Cucciare, Kristina M Kennedy, Xiaotong Han, Christine Timko, Nickolas Zaller, Brenda M Booth
Rural substance users are less likely than their urban peers to use formal substance use treatment. It is therefore important to understand how the utilization of potentially more appealing care options, such as outpatient medical care (OMC), may affect substance use over time. This study sought to examine whether the number of OMC visits, after controlling for important covariates, was associated with days of alcohol, crack and powder cocaine, and methamphetamine use among a sample of rural stimulant users over a three year period...
March 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29414387/methamphetamine-dependence-in-methadone-treatment-services-in-iran-the-first-literature-review-of-a-new-health-concern
#16
REVIEW
Zahra Alammehrjerdi, Nadine Ezard, Kate Dolan
BACKGROUND: Methamphetamine dependence is a serious health problem among Iranian methadone patients. AIM: The current study is the first research that reviewed the prevalence of methamphetamine dependence and the associated harms among Iranian methadone patients. The other aims were to review the history of receiving methamphetamine treatment among methadone patients and the evaluated psychosocial treatments for methamphetamine dependence and/or associated harms...
January 6, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29402377/towards-a-continuum-of-care-concerning-chemsex-issues
#17
Ingrid Bakker, Leon Knoops
In response to the apparent rise in chemsex in the Netherlands Mainline Foundation interviewed 27 MSM about their crystal meth use and/or experience with injecting in a sexual context. These men were interviewed about their motivation for methamphetamine use, their sexual risk-taking behaviour, methods and context of their drug use, and their information- and care needs. In 2015 this resulted in the status report Tina and Slamming: MSM, Crystal Meth Use and Intravenous Drug Use in a Sexual Context. Following the publication of this report Mainline foundation has been offering harm-reduction intervention for MSM and promoting the development of a continuum of care by building networks, training professionals and investing in advocacy...
February 6, 2018: Sexual Health
https://www.readbyqxmd.com/read/29397643/associations-of-the-neighborhood-environment-with-substance-use-a-cross-sectional-investigation-among-patients-in-compulsory-drug-detention-centers-in-thailand
#18
Suneerat Yangyuen, Manop Kanato, Udomsak Mahaweerawat
Objectives: To identify the associations of characteristics of the neighborhood environment with substance abuse among clients receiving treatment for drug abuse in Thailand. Methods: A cross-sectional study was conducted of 1128 drug addicts from 28 neighborhoods who were receiving treatment at all 7 compulsory drug detention centers in Thailand. A trained interviewer conducted structured interviews with the subjects about substance use and the perceived neighborhood environment in their community...
January 2018: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/29397534/chronic-methylphenidate-alters-tonic-and-phasic-glutamate-signaling-in-the-frontal-cortex-of-a-freely-moving-rat-model-of-adhd
#19
Erin M Miller, Jorge E Quintero, Francois Pomerleau, Peter Huettl, Greg A Gerhardt, Paul E A Glaser
Glutamate dysfunction has been implicated in a number of substance of abuse studies, including cocaine and methamphetamine. Moreover, in attention-deficit/hyperactivity disorder (ADHD), it has been discovered that when the initiation of stimulant treatment occurs during adolescence, there is an increased risk of developing a substance use disorder later in life. The spontaneously hypertensive rat (SHR) serves as a phenotype for ADHD and studies have found increased cocaine self-administration in adult SHRs when treated with the stimulant methylphenidate (MPH) during adolescence...
February 3, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29397001/the-relationship-between-methamphetamine-use-and-heterosexual-behaviour-evidence-from-a-prospective-longitudinal-study
#20
Rebecca McKetin, Dan I Lubman, Amanda Baker, Sharon Dawe, Joanne Ross, Richard P Mattick, Louisa Degenhardt
AIMS: To estimate the extent to which specific sexual behaviours (being sexually active, having multiple sex partners, casual sex, condomless casual sex, anal sex, and condomless anal sex) change during periods of methamphetamine use. DESIGN: Within-person estimates for the relationship between methamphetamine use and sexual behaviour were derived from longitudinal panel data from the MATES cohort (2006 to 2010). SETTING: Sydney and Brisbane, Australia...
February 3, 2018: Addiction
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