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https://www.readbyqxmd.com/read/29687308/exposure-to-far-infrared-ray-protects-methamphetamine-induced-behavioral-sensitization-in-glutathione-peroxidase-1-knockout-mice-via-attenuating-mitochondrial-burdens-and-dopamine-d1-receptor-activation
#1
Huynh Nhu Mai, Naveen Sharma, Eun-Joo Shin, Bao Trong Nguyen, Ji Hoon Jeong, Choon-Gon Jang, Eun-Hee Cho, Seung Yeol Nah, Nam Hun Kim, Toshitaka Nabeshima, Hyoung-Chun Kim
Evidence indicates that stress conditions might lead to drug dependence. Recently, we have demonstrated that exposure to far infrared ray (FIR) attenuates acute restraint stress via induction of glutathione peroxidase-1 (GPx-1) gene. We investigated whether FIR affects methamphetamine (MA)-induced behavioral sensitization and whether FIR-mediated pharmacological activity requires interaction between dopamine receptor and GPx-1 gene. We observed that MA treatment significantly increased GPx-1 expression in the striatum of wild-type (WT) mice...
April 23, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29685329/cohort-study-of-hiv-positive-and-negative-methamphetamine-users
#2
Vladimir W Spolsky, Jason Clague, Vivek Shetty
BACKGROUND: The effects of methamphetamine (MA) on caries have been well documented. Little, however, is known about its effects on the periodontium. The authors conducted this study to determine the prevalence and severity of periodontal disease in an urban population of HIV-positive MA users. METHODS: This cross-sectional survey was conducted in one of the most populous urban areas of Los Angeles County, California, beset with high rates of MA use. Participants were recruited by a combination of street outreach methods, referral from drug treatment centers, and word of mouth...
April 20, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29679670/mindfulness-based-relapse-prevention-combined-with-virtual-reality-cue-exposure-for-methamphetamine-addiction-study-protocol-for-a-randomized-controlled-trial
#3
XiJing Chen, Dongmei Wang, Lidan Zhou, Markus Winkler, Paul Pauli, Nan Sui, Yonghui Li
BACKGROUND: Mindfulness-based relapse prevention (MBRP) is a method that combines cognitive behavioral relapse prevention with mindfulness practice. Research shows that MBRP can effectively reduce negative emotions and craving in people with substance use disorders (SUDs). An important part of MBRP is to practice mindfulness meditation to cope with high-risk situations for relapse, such as stimuli and situations associated with drug taking. Virtual reality cue exposure (VRCE) may be a complementary approach to MBRP as it allows for controlled and graded presentations of various high-risk situations with distal and proximal drug cues...
April 18, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29644532/methamphetamine-induces-apoptosis-of-microglia-via-the-intrinsic-mitochondrial-dependent-pathway
#4
Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahajan
Methamphetamine (METH) is a drug of abuse, the acute and chronic use of which induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Our goals were to understand the impact of METH on microglial mitochondrial respiration and to determine whether METH induces the activation of the mitochondrial-dependent intrinsic apoptosis pathway in microglia. We assessed the expression of pro- apoptosis genes using qPCR of RNA extracted from a human microglial cell line (HTHU). We examined the apoptosis-inducing effects of METH on microglial cells using digital holographic microscopy (DHM) to quantify real-time apoptotic volume decrease (AVD) in microglia in a noninvasive manner...
April 11, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29626740/the-relationship-between-impulsivity-and-methamphetamine-use-severity-in-a-community-sample
#5
Nathasha R Moallem, Kelly E Courtney, Lara A Ray
BACKGROUND: Abuse of psychostimulants, including methamphetamine (MA), has been linked to heightened impulsivity. While previous research has demonstrated differences in impulsivity between MA users and non-substance users, less is known about variability in impulsivity within MA users and whether the severity of MA use related problems predicts impulsivity within individuals who regularly use MA. This study aims to elucidate the relationship between impulsivity and MA use severity. METHOD: Non-treatment seeking individuals who reported regular MA use (n = 177) completed an impulsivity battery comprising self-report and behavioral measures...
March 27, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29605540/the-management-of-methamphetamine-use-in-sexual-settings-among-men-who-have-sex-with-men-in-malaysia
#6
Sin How Lim, Mohd Akbar, Jeffrey A Wickersham, Adeeba Kamarulzaman, Frederick L Altice
BACKGROUND: The intentional use of illicit drugs for sexual purposes (also known as 'chemsex') is well known within the MSM communities in Malaysia although research in this population is scarce primarily because both drug use and homosexuality are illegal and stigmatised in Malaysia. METHODS: From April to December 2014, interviews were conducted with twenty men (age range 21-43) living in Greater Kuala Lumpur who had sexual intercourse with other men in the past 6 months and who used illicit drugs at least monthly in the past 3 months...
March 28, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29604294/the-effect-of-n-acetylcysteine-or-bupropion-on-methamphetamine-self-administration-and-methamphetamine-triggered-reinstatement-of-female-rats
#7
Sergios Charntikov, Steven T Pittenger, Cindy M Pudiak, Rick A Bevins
N-acetylcysteine and bupropion are two promising candidate medications for treatment of substance use disorder. The effects of N-acetylcysteine or bupropion on methamphetamine self-administration of female rats are not well understood. To fill this gap, this study assessed the effects of N-acetylcysteine (0, 30, 60, or 120 mg/kg) and bupropion (0, 10, 30, and 60 mg/kg) on methamphetamine self-administration of female rats across the natural estrous cycle. Following a completed dose-response curve, responding for methamphetamine self-administration was extinguished and the effects of N-acetylcysteine or bupropion on methamphetamine-triggered reinstatement was evaluated in separate experiments...
March 28, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29602278/dark-classics-in-chemical-neuroscience-methamphetamine
#8
Thomas J Abbruscato, Paul C Trippier
Methamphetamine has the second highest prevalence of drug abuse after cannabis, with estimates of 35 million users worldwide. The (S)-(+)-enantiomer is the illicit drug, active neurostimulant and eutomer, while the (R)-(-)-enantiomer is contained in over the counter decongestants. While designated a schedule II drug in 1970, (S)-(+)-methamphetamine is available by prescription for the treatment of attention-deficit disorder and obesity. The illicit use of (S)-(+)-methamphetamine results in the sudden 'rush' of stimulation to the motivation, movement, pleasure and reward centers in the brain, caused by rapid release of dopamine...
March 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29595368/the-care-of-patients-using-methamphetamine-in-the-emergency-department-perception-of-nurses-residents-and-faculty
#9
John R Richards, J Adam Hawkins, Eric W Acevedo, Erik G Laurin
BACKGROUND: To determine differences in perception between nurses, residents, and faculty regarding characteristics and treatment of patients who use methamphetamine (meth). METHODS: Survey study performed at an urban, university Level I trauma medical center. RESULTS: 80 nurses, 39 residents, and 45 faculty completed the survey. All groups agreed meth was a significant problem nationwide and in our emergency department (ED). Nurses estimated 33% of their patients used meth, which differed from residents (18%) and faculty (15%)...
March 29, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29579065/the-effect-of-estrogenic-compounds-on-psychosis-like-behaviour-in-female-rats
#10
Alyssa Sbisa, Maarten van den Buuse, Andrea Gogos
17β-estradiol treatment has shown benefit against schizophrenia symptoms, however long-term use may be associated with negative side-effects. Selective estrogen receptor modulators, such as raloxifene and tamoxifen, have been proposed as suitable alternatives to 17β-estradiol. An isomer of 17β-estradiol, 17α-estradiol, is considered less carcinogenic, and non-feminising in males, however little is known about its potential as a treatment for schizophrenia. Moreover, the mechanism underlying the therapeutic action of estrogens remains unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29576706/rhynchophylline-downregulates-phosphorylated-camp-response-element-binding-protein-nuclear-receptor-related-1-and-brain-derived-neurotrophic-factor-expression-in-the-hippocampus-of-ketamine-induced-conditioned-place-preference-rats
#11
Youli Guo, Chaohua Luo, Genghong Tu, Chan Li, Yi Liu, Wei Liu, Ken Kin Lam Yung, Zhixian Mo
Background: Addiction to ketamine is becoming a serious public health issues, for which there exists no effective treatment. Rhynchophylline (Rhy) is an alkaloid extracted from certain Uncaria species that is well known for both its potent anti-addictive and neuroprotective properties. Increasing evidence supports the contributions of cAMP response element binding protein (CREB), nuclear receptor-related-1 (Nurr1), and brain-derived neurotrophic factor (BDNF) in modulating neural and behavioral plasticity which was induced by addictive drugs...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29574368/estimation-of-the-consumption-of-illicit-drugs-during-special-events-in-two-communities-in-western-kentucky-usa-using-sewage-epidemiology
#12
Katelyn S Foppe, Dena R Hammond-Weinberger, Bikram Subedi
Sewage epidemiology is a cost-effective, comprehensive, and non-invasive technique capable of determining semi-real-time community usage of drugs utilizing the concentration of drug residues in wastewater, wastewater inflow, and the population size served by a wastewater treatment plant. In this study, semi-real-time consumption rates of ten illicit drugs were determined using sewage epidemiology during special events including Independence Day, the 2017 solar eclipse, and the first week of an academic semester in the Midwestern United States...
March 22, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29574227/mtor-signaling-in-the-nucleus-accumbens-mediates-behavioral-sensitization-to-methamphetamine
#13
Shin-Han Huang, Wan-Rong Wu, Li-Ming Lee, Pei-Rong Huang, Jin-Chung Chen
Chronic psychostimulant treatment in rodents readily produces behavioral sensitization, which reflects altered brain function in response to repeated drug exposure. Numerous morphological and biochemical investigations implicate altered neural plasticity in striatal medium spiny neurons (MSNs) as an essential component in behavioral sensitization. The mammalian target of the rapamycin (mTOR) signaling pathway, a key regulator of synaptic neuroplasticity, in the ventral striatum of methamphetamine (METH) -sensitized mice was investigated to determine if a link exists with the development of METH sensitization...
March 21, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29572053/exposure-to-far-infrared-rays-attenuates-methamphetamine-induced-recognition-memory-impairment-via-modulation-of-the-muscarinic-m1-receptor-nrf2-and-pkc
#14
Huynh Nhu Mai, Naveen Sharma, Eun-Joo Shin, Bao Trong Nguyen, Phuong Tram Nguyen, Ji Hoon Jeong, Choon Gon Jang, Eun-Hee Cho, Seung Yeol Nah, Nam Hun Kim, Toshitaka Nabeshima, Hyoung-Chun Kim
We demonstrated that activation of protein kinase Cδ (PKCδ) and inactivation of the glutathione peroxidase-1 (GPx-1)-dependent systems are critical for methamphetamine (MA)-induced recognition memory impairment. We also demonstrated that exposure to far-infrared rays (FIR) causes induction of the glutathione (GSH)-dependent system, including induction of the GPx-1 gene. Here, we investigated whether exposure to FIR rays affects MA-induced recognition memory impairment and whether it modulates PKC, cholinergic receptors, and the GSH-dependent system...
March 20, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29571720/prenatal-exposure-to-modafinil-alters-behavioural-response-to-methamphetamine-in-adult-male-mice
#15
Jana Ruda-Kucerova, Jana Pistovcakova, Petra Amchova, Alexandra Sulcova, Alena Machalova
Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy. However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance. Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern. The aim of this study was to assess behavioural and immune effects of prenatal modafinil exposure in mice and to evaluate the reaction to methamphetamine exposure on these animals in adult age...
March 20, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29550740/factors-associated-with-concurrent-heroin-use-among-patients-on-methadone-maintenance-treatment-in-vietnam-a-24-month-retrospective-analysis-of-a-nationally-representative-sample
#16
Thai Hoang, Hong Nguyen, Ray W Shiraishi, Mai Nguyen, Trista Bingham, Diep Nguyen, Tam Nguyen, Hao Duong, Sheryl Lyss, Hien Tran
BACKGROUND: Methadone maintenance treatment (MMT) is highly effective for reducing heroin use and HIV transmission among people who inject opioids. We sought to measure and understand factors associated with continued heroin use, a critical factor affecting treatment outcome among MMT patients in Vietnam. METHOD: We collected data from medical charts of a nationally representative sample of patients who were on MMT from May 2008 to December 2013. We selected 10 MMT clinics using probability proportional to size and 50 patients/clinic by systematic random sampling...
March 15, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29545881/inhibitory-effects-of-methamphetamine-on-mast-cell-activation-and-cytokine-chemokine-production-stimulated-by-lipopolysaccharide-in-c57bl-6j-mice
#17
Li Xue, Yan Geng, Ming Li, Yao-Feng Jin, Hui-Xun Ren, Xia Li, Feng Wu, Biao Wang, Wei-Ying Cheng, Teng Chen, Yan-Jiong Chen
Previous studies have demonstrated that methamphetamine (MA) influences host immunity; however, the effect of MA on lipopolysaccharide (LPS)-induced immune responses remains unknown. Mast cells (MCs) are considered to serve an important role in the innate and acquired immune response, but it remains unknown whether MA modulates MC activation and LPS-stimulated cytokine production. The present study aimed to investigate the effect of MA on LPS-induced MC activation and the production of MC-derived cytokines in mice...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29536284/testing-the-efficacy-of-combined-motivational-interviewing-and-cognitive-behavioral-skills-training-to-reduce-methamphetamine-use-and-improve-hiv-medication-adherence-among-hiv-positive-gay-and-bisexual-men
#18
Jeffrey T Parsons, Steven A John, Brett M Millar, Tyrel J Starks
Prior research has identified subgroups of HIV-positive gay and bisexual men (GBM) based upon information, motivation, and behavioral skills (IMB) profiles related to HIV medication adherence and methamphetamine use. We conducted a randomized controlled trial of a combined motivational interview (MI) and cognitive behavioral therapy (CBT) intervention tailored specifically to the unique context of HIV-positive GBM, and tested whether IMB profiles moderated treatment effects. HIV-positive GBM (N = 210) were randomized to MI + CBT or an attention-matched education control...
March 13, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29529435/assessment-of-drugs-and-personal-care-products-biomarkers-in-the-influent-and-effluent-of-two-wastewater-treatment-plants-in-ho-chi-minh-city-vietnam
#19
Hue T Nguyen, Phong K Thai, Sarit L Kaserzon, Jake W O'Brien, Geoff Eaglesham, Jochen F Mueller
Wastewater samples were collected at the influent and effluent of two wastewater treatment plants (WWTPs) in Ho Chi Minh City, Vietnam and then pooled to daily samples over multiple days using 6 hourly grab samples. The aim was to provide a first assessment of the occurrence, consumption, removal and release of a range of organic chemicals including pharmaceuticals and personal care products (PPCPs), illicit drugs, an artificial sweetener, tobacco and its metabolites and alcohol biomarkers (referred to here as DPCPBs)...
March 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29521774/overdoses-and-substance-toxicity-in-patients-admitted-to-intensive-care-units-in-a-midwestern-u-s-city
#20
Craig A Schuring, Daniel L Dodge, Tyler J Whitcomb, Geoffrey C Wall, Hayden L Smith, Greg A Hicklin
Toxic exposures with serious outcomes have increased over the last decade. Limited data exists on the pattern and outcomes of overdose-exposure patients requiring intensive care unit (ICU) admission. The primary objective of this study was to characterize the causes, treatments, and outcomes of toxic exposures in a mid-sized Midwestern health system. The secondary objective was to report cumulative economic costs associated with these patients. Data were obtained from medical records of patients 18 years or older with a diagnosis code of overdose admitted to the ICU at 2 teaching hospitals between August 1, 2012, and July 31, 2014...
March 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
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