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https://www.readbyqxmd.com/read/29038721/gender-differences-in-substance-use-patterns-and-disorders-among-an-iranian-patient-sample-receiving-methadone-maintenance-treatment
#1
Amir Ghaderi, Maryam Motmaen, Iraj Abdi, Morad Rasouli-Azad
BACKGROUND: The current prevalence rate of substance abuse and dependence, represents an increasing trend of substance abuse and dependence among women, and the results of epidemiology studies indicate that substance use patterns are different between men and women. This study aimed to determine gender differences in substance use patterns and disorders among the patients undergoing methadone maintenance treatment. METHODS: This cross-sectional study was conducted throughout a specified time bracket ranging from September 2012 through March 2013 in Methadone Maintenance Treatment (MMT) clinics of Mashhad, Iran...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29036309/chiral-analysis-of-methamphetamine-in-oral-fluid-samples-a-method-to-distinguish-licit-from-illicit-drug-use
#2
Damon Borg, Elizabeth Kolb, Cindy Lantigua, Richard Stripp
Methamphetamine (MAMP) is a popular illicit drug abused for its central nervous system stimulating effects. MAMP is also used therapeutically in the treatment of overeating disorders, narcolepsy, attention deficit disorder, in over-the-counter (OTC) products to ease nasal congestion. MAMP exists in two enantiomeric forms, dextrorotary (d-MAMP) or levorotary (l-MAMP). The compounds are similar in chemical structure, simply differing in the orientation of functional groups around the asymmetric carbon. In part because of the availability of l-MAMP in OTC nasal inhalers, forensic guidelines require a sample to contain greater than 20% d-MAMP to consider illicit drug use when interpreting results...
September 25, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29035917/decreases-in-smoking-during-treatment-for-methamphetamine-use-disorders-preliminary-evidence
#3
Sterling McPherson, Michael Orr, Crystal Lederhos, Michael McDonell, Emily Leickly, Katherine Hirchak, Oladunni A Oluwoye, Sean M Murphy, Matthew Layton, John M Roll
Despite high rates of smoking (70-90%) and the severely negative impact of smoking on physical and mental health, only 12% of individuals receiving stimulant-use disorder treatment also receive smoking-cessation treatment. The aim of this investigation was to examine the effect of a contingency management (CM) intervention targeting methamphetamine (MA) use on cigarette smoking. Sixty-one adults with MA-use disorders who were smokers were assigned to CM or standard psychosocial treatment. Rates of smoking-negative breath samples (carbon monoxide <3 ppm) were compared between the two groups while controlling for baseline carbon monoxide level, marijuana use, MA use, and time...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035155/effects-of-social-and-spatial-contexts-on-young-latinas-methamphetamine-use-initiation
#4
Ann M Cheney, Christine N Newkirk, Vhuhwavho M Nekhavhambe, Matthew Baron Rotondi, Alison Hamilton
In this article, we examine methamphetamine (meth) use initiation as influenced by Latinas' social positions within institutions (e.g., family and economy). We conducted ethnographic fieldwork in five women's residential substance use treatment facilities in Los Angeles County with women who considered meth to be their primary drug of choice. Using an urban ethnographic framing, we demonstrate the effects of low-income young Latinas' spatial- and social-context rendered vulnerability to abuse and neglect, and the resulting emotional distress, on meth use initiation...
October 16, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/29030218/acupuncture-suppresses-intravenous-methamphetamine-self-administration-through-gaba-receptor-s-mediation
#5
Yi Jeong Choi, Nam Jun Kim, Rong Jie Zhao, Da Hye Kim, Chae Ha Yang, Hee Young Kim, Young S Gwak, Eun Young Jang, Jae Su Kim, Yun Kyu Lee, Hyun Jong Lee, Sang Nam Lee, Sung Chul Lim, Bong Hyo Lee
OBJECTIVES: Methamphetamine is one of the widely abused drugs. In spite of a number of studies, there is still little successful therapy to suppress the methamphetamine abuse. Acupuncture has shown to attenuate the reinforcing effects of psychostimulant. Based on, the present study investigated if acupuncture could suppress intravenous methamphetamine self-administration behavior. In addition, a possible neuronal mechanism was investigated. MATERIALS & METHODS: Male Sprague-Dawley rats weighing 270-300g were trained to intake food pellet...
October 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29024664/the-anterior-insular-cortex%C3%A2-central-amygdala-glutamatergic-pathway-is-critical-to-relapse-after-contingency-management
#6
Marco Venniro, Daniele Caprioli, Michelle Zhang, Leslie R Whitaker, Shiliang Zhang, Brandon L Warren, Carlo Cifani, Nathan J Marchant, Ofer Yizhar, Jennifer M Bossert, Cristiano Chiamulera, Marisela Morales, Yavin Shaham
Despite decades of research on neurobiological mechanisms of psychostimulant addiction, the only effective treatment for many addicts is contingency management, a behavioral treatment that uses alternative non-drug reward to maintain abstinence. However, when contingency management is discontinued, most addicts relapse to drug use. The brain mechanisms underlying relapse after cessation of contingency management are largely unknown, and, until recently, an animal model of this human condition did not exist...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/28993979/methamphetamine-augments-concurrent-astrocyte-mitochondrial-stress-oxidative-burden-and-antioxidant-capacity-tipping-the-balance-in-hiv-associated-neurodegeneration
#7
Kathleen Borgmann, Anuja Ghorpade
Methamphetamine (METH) use, with and without human immunodeficiency virus (HIV)-1 comorbidity, exacerbates neurocognitive decline. Oxidative stress is a probable neurotoxic mechanism during HIV-1 central nervous system infection and METH abuse, as viral proteins, antiretroviral therapy and METH have each been shown to induce mitochondrial dysfunction. However, the mechanisms regulating mitochondrial homeostasis and overall oxidative burden in astrocytes are not well understood in the context of HIV-1 infection and METH abuse...
October 9, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28987070/impulsivity-predicts-poorer-improvement-in-quality-of-life-during-early-treatment-for-people-with-methamphetamine-dependence
#8
Adam J Rubenis, Rebecca E Fitzpatrick, Dan I Lubman, Antonio Verdejo-Garcia
BACKGROUND AND AIMS: Methamphetamine dependence is associated with heightened impulsivity and diminished quality of life, but the link between impulsivity and changes in quality of life during treatment has not been examined. We aimed to investigate how different elements of impulsivity predict change in quality of life in the six weeks after engaging in treatment. DESIGN: Longitudinal, observational cohort study. SETTING: Public and private detoxification and rehabilitation facilities in metropolitan Melbourne, Australia...
October 7, 2017: Addiction
https://www.readbyqxmd.com/read/28970640/a-comparison-of-mazur-s-k-and-area-under-the-curve-for-describing-steep-discounters
#9
Jin H Yoon, Richard De La Garza, Thomas F Newton, Robert Suchting, Matthew T Weaver, Gregory S Brown, Yasmine Omar, Ilana Haliwa
Delay discounting describes how a reward loses value as a function of increasing delay to its receipt and has been reliably associated with a variety of vulnerable populations including those with substance use disorders (SUDs). Two commonly used models to assess delay discounting in the field of SUDs include log k derived from Mazur's hyperbolic equation and area under the curve (AUC). In the current study, we compared log k with AUC on delay discounting data obtained from non-treatment seeking, cocaine- and methamphetamine-dependent volunteers...
September 2017: Psychological Record
https://www.readbyqxmd.com/read/28960173/family-behavior-therapy-for-alcohol-and-drug-problems-in-later-life
#10
Christopher P Plant, Jason M Holland
Alcohol and drug use problems among older individuals are a growing public health concern. However, few treatments have been developed for this population, despite an emerging body of literature suggesting that older substance users are more likely to benefit from interventions tailored to meet their specific needs. In particular, older adults with a history of substance abuse have expressed a preference for treatments that focus on financial problems, physical health, and mobility issues, and make attempts to prescriptively involve supportive others in treatment...
June 30, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28960166/perceived-treatment-need-and-latent-transitions-in-heroin-and-methamphetamine-polydrug-use-among-people-who-inject-drugs-in-tijuana-mexico
#11
Meredith C Meacham, Scott C Roesch, Steffanie A Strathdee, Tommi L Gaines
People who inject drugs (PWID) in Tijuana, Mexico, use heroin and/or methamphetamine. While polydrug use is associated with HIV risk behavior, less is known about the stability of polydrug use patterns over time and how polydrug use is related to perceived treatment need. Within a cohort of PWID in Tijuana (N = 735) we sought to (1) characterize subgroups of polydrug and polyroute use from baseline to six months; (2) determine the probabilities of transitioning between subgroups; and (3) examine whether self-reported need for help for drug use modified these transition probabilities...
September 29, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28959203/endoplasmic-reticulum-stress-mediates-methamphetamine-induced-blood-brain-barrier-damage
#12
Xiaojuan Qie, Di Wen, Hongyan Guo, Guanjie Xu, Shuai Liu, Qianchao Shen, Yi Liu, Wenfang Zhang, Bin Cong, Chunling Ma
Methamphetamine (METH) abuse causes serious health problems worldwide, and long-term use of METH disrupts the blood-brain barrier (BBB). Herein, we explored the potential mechanism of endoplasmic reticulum (ER) stress in METH-induced BBB endothelial cell damage in vitro and the therapeutic potential of endoplasmic reticulum stress inhibitors for METH-induced BBB disruption in C57BL/6J mice. Exposure of immortalized BMVEC (bEnd.3) cells to METH significantly decreased cell viability, induced apoptosis, and diminished the tightness of cell monolayers...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28956316/anesthetic-implications-of-recreational-drug-use
#13
Pierre Beaulieu
PURPOSE: As the use of recreational drugs increases, the likelihood of an anesthesiologist perioperatively encountering patients using or addicted to these drugs will also increase. PRINCIPAL FINDINGS: Addicted patients may present for anesthetic care in a variety of circumstances in everyday elective surgeries or in acute or life-saving situations, such as emergency Cesarean delivery or trauma surgery. Therefore, it is important for anesthesiologists to know about the most common illicit drugs being used, their clinical presentation and side effects, and the anesthetic options that are beneficial or detrimental to these patients...
September 27, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28942287/the-costs-of-crime-associated-with-stimulant-use-in-a-canadian-setting
#14
Benjamin Enns, Emanuel Krebs, Kora DeBeck, Kanna Hayashi, M-J Milloy, Lindsey Richardson, Evan Wood, Bohdan Nosyk
BACKGROUND: Costs attributable to criminal activity are a major component of the economic burden of substance use disorders, yet there is a paucity of empirical evidence on this topic. Our aim was to estimate the costs of crime associated with different forms and intensities of stimulant use. METHODS: Retrospective cohort study, including individuals from three prospective cohorts in Vancouver, Canada, measured biannually (2011-2015), reporting stimulant use at baseline assessment...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28919515/trace-amine-associated-receptor-1-regulation-of-methamphetamine-induced-neurotoxicity
#15
Nicholas B Miner, Josh S Elmore, Michael H Baumann, Tamara J Phillips, Aaron Janowsky
Trace amine-associated receptor 1 (TAAR1) is activated by methamphetamine (MA) and modulates dopaminergic (DA) function. Although DA dysregulation is the hallmark of MA-induced neurotoxicity leading to behavioral and cognitive deficits, the intermediary role of TAAR1 has yet to be characterized. To investigate TAAR1 regulation of MA-induced neurotoxicity, Taar1 transgenic knock-out (KO) and wildtype (WT) mice were administered saline or a neurotoxic regimen of 4 i.p. injections, 2h apart, of MA (2.5, 5, or 10mg/kg)...
September 15, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28918668/current-status-and-future-prospects-for-the-development-of-substance-abuse-vaccines
#16
R David Heekin, Daryl Shorter, Thomas R Kosten
Substance use disorders (SUD) are a significant threat to both individual and public health. To date, SUD pharmacotherapy has focused primarily on agonist medications (i.e. nicotine replacement therapy for tobacco use disorder; methadone and buprenorphine for opioid use disorder), antagonist medications (i.e. naltrexone for opioid use disorder), and aversive therapy (i.e. disulfiram for alcohol use disorder). Pharmacotherapeutic approaches utilizing an immunological framework for medication development represent an important focus of study for treatment of these illnesses...
November 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28917981/intranasal-insulin-treatment-alleviates-methamphetamine-induced-anxiety-like-behavior-and-neuroinflammation
#17
Elmira Beirami, Shahrbanoo Oryan, Seyedeh Masoumeh Seyedhosseini Tamijani, Abolhassan Ahmadiani, Leila Dargahi
Insulin, as a peptide hormone, has recently gained attention for its pro-cognitive, anti-inflammatory and neuroprotective effects in the central nervous system (CNS). Most studies have indicated anxiogenic and neuroinflammatory effects of methamphetamine (MA) and other psychostimulants, even after periods of abstinence. The present study aimed to examine whether intranasal (IN) insulin treatment with high CNS bioavailability and minimal systemic side effects, can reverse the anxiety-like behavior and neuroinflammation induced by repeated MA administration...
September 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28917948/effects-of-methamphetamine-on-alloparental-behavior-in-male-and-female-prairie-voles
#18
Adam N Perry, Richard J Ortiz, Keziah R Hernandez, Bruce S Cushing
Psychostimulant abuse is associated with a variety of impairments in social functioning, including an increased frequency of depression and aggression and deficits in social cognition. Psychostimulants reduce social investigation in rats and mice; however, it is less clear how other forms of social behavior (e.g., prosocial behavior) are affected. Females are also generally more sensitive to the effects of psychostimulants on locomotion and stereotyped behavior, which suggests that females might also display greater disruption of prosocial behavior...
September 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28912535/molecular-mechanisms-underlying-the-involvement-of-the-sigma-1-receptor-in-methamphetamine-mediated-microglial-polarization
#19
Jie Chao, Yuan Zhang, Longfei Du, Rongbin Zhou, Xiaodong Wu, Kai Shen, Honghong Yao
Our previous study demonstrated that the sigma-1 receptor is involved in methamphetamine-induced microglial apoptosis and death; however, whether the sigma-1 receptor is involved in microglial activation as well as the molecular mechanisms underlying this process remains poorly understood. The aim of this study is to demonstrate the involvement of the sigma-1 receptor in methamphetamine-mediated microglial activation. The expression of σ-1R, iNOS, arginase and SOCS was examined by Western blot; activation of cell signaling pathways was detected by Western blot analysis...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903402/impact-of-chronic-methamphetamine-treatment-on-the-atherosclerosis-formation-in-apoe-mice-fed-a-high-cholesterol-diet
#20
Pengfei Zhu, Lun Li, Bo Gao, Mingjing Zhang, Yuting Wang, Ye Gu, Liqun Hu
BACKGROUND: We previously reported that methamphetamine could promote atherosclerosis (AS) in ApoE-/- mice fed normal chow. We herein observed the impact of methamphetamine on AS in ApoE-/- mice fed a high cholesterol diet and explored the potential mechanisms. RESULTS AND MATERIALS AND METHODS: Male ApoE-/- mice fed a high cholesterol diet were treated with saline (NS, n = 5) or methamphetamine [8 mg/kg/day (M8, n = 6) through intraperitoneal injection] for 24 weeks...
August 15, 2017: Oncotarget
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