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https://www.readbyqxmd.com/read/29915529/the-main-molecular-mechanisms-underlying-methamphetamine-induced-neurotoxicity-and-implications-for-pharmacological-treatment
#1
REVIEW
Xue Yang, Yong Wang, Qiyan Li, Yaxian Zhong, Liangpei Chen, Yajun Du, Jing He, Lvshuang Liao, Kun Xiong, Chun-Xia Yi, Jie Yan
Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the accurate mechanism of toxic effect of the drug on central nervous system (CNS) has not yet been completely deciphered. Besides, effective treatment strategies toward METH neurotoxicity remain scarce and more efficacious drugs are to be developed. In this review, we summarize cellular and molecular bases that might contribute to METH-elicited neurotoxicity, which mainly include oxidative stress, excitotoxicity, and neuroinflammation...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29908234/agmatine-attenuates-methamphetamine-induced-passive-avoidance-learning-and-memory-and-camkii-%C3%AE-gene-expression-deteriorations-in-hippocampus-of-rat
#2
Maryam Noorbakhshnia, Arsham Rashidkaboli, Mahnaz Pakatchian, Siamak Beheshti
Methamphetamine (METH) abuse is one the most worldwide problems with wide-ranging effects on the central nervous system (CNS). Chronic METH abuse can associate with cognitive abnormalities and neurodegenerative changes in the brain. Agmatine, a cationic polyamine, has been proposed as a neuromodulator that modulates many effects of abused drugs. The aim of this study was to determine if agmatine can decrease the impairment effect of METH on memory and hippocampal CaMKII-α gene expression, a gene that plays a major role in memory...
June 13, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29892312/the-prevalence-of-methamphetamine-dependence-among-iranian-women-in-methadone-maintenance-therapy-in-tehran-iran
#3
Omid Massah, Afsaneh Moradi
Objective: To date, there has been no specific survey of the prevalence of methamphetamine (MA) dependence among Iranian women in methadone maintenance therapy (MMT). The current study aimed at addressing this critical gap in the literature. Method : This study was part of a larger cross-sectional survey, which was conducted in 36 MMT clinics in Tehran during 2015 and 2016. A researcher-designed questionnaire was devised to collect data on demographics and drug and treatment characteristics. Data were analyzed using SPSS Version 19...
January 2018: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29889118/interest-in-getting-help-to-reduce-or-stop-substance-use-among-syringe-exchange-clients-who-use-opioids
#4
Madeline C Frost, Emily C Williams, Susan Kingston, Caleb J Banta-Green
OBJECTIVES: Opioid use is a growing problem in the United States. Despite existence of effective treatments (eg, opioid agonist medication), most people with opioid use disorder do not receive treatment. Increasing treatment receipt is an essential component of the response to the opioid crisis. We examined factors associated with interest in getting help to reduce or stop substance use among syringe exchange program (SEP) clients who reported using opioids. METHODS: Surveys were administered at 17 SEPs across Washington State during 2015; 436 respondents who reported recent opioid use and not receiving current treatment were eligible for this analysis...
June 7, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29886101/spherical-neutral-gold-nanoparticles-improve-anti-inflammatory-response-oxidative-stress-and-fibrosis-in-alcohol-methamphetamine-induced-liver-injury-in-rats
#5
Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B Chan, Raimundo Fernandes de Araújo Júnior
This study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and Methamphetamine (METH).The liver injury was induced by gavage administrations of 30% alcoholic solution (7 g/kg) once a day during 28 days, followed by METH (10 mg/kg) on the 20th and 28th days of treatment. GNPs treatment (724.96 µg/kg) during the ethanol and METH exposure was associated with reduced steatosis, hepatic cord degeneration, fibrosis and necrosis...
June 7, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29885289/diazepam-suppresses-the-stress-induced-dopaminergic-release-in-the-amygdala-of-methamphetamine-sensitized-rat
#6
Takaaki Kawano, Hidehiro Oshibuchi, Masahiko Kawano, Hiroyuki Muraoka, Takahiro Tsutsumi, Makiko Yamada, Jun Ishigooka, Katsuji Nishimura, Ken Inada
Although the benzodiazepine class of drugs has proven useful in treating anxiety symptoms, recent studies yield no consistent empirical support for their use in treating psychiatric disorders. However, animal studies using a fear conditioning paradigm have suggested that benzodiazepines facilitate fear memory extinction, dependent on treatment timing and subject conditions. However, we have no data on the effect of subject conditions. The purpose of this study was to investigate whether the effect of benzodiazepines depends on hypersensitivity to fear-memory processing...
June 6, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29883856/polydrug-use-patterns-risk-behavior-and-unmet-healthcare-need-in-a-community-based-sample-of-women-who-use-cocaine-heroin-or-methamphetamine
#7
Jennifer Lorvick, Erica N Browne, Barrot H Lambdin, Megan Comfort
BACKGROUND: The use of multiple illicit drugs (polydrug use) is associated with health-related harms and elevated risk of drug overdose. Polydrug use in common among women who use 'hard' drugs, such as cocaine, heroin or methamphetamine. METHODS: Quantitative data collection was conducted with a community-recruited sample of 624 women who used heroin, methamphetamine or cocaine in Oakland, CA during 2014-2015. We conducted latent class analysis to classify polydrug use patterns...
May 24, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29869828/gaps-in-the-ice-methamphetamine-in-australia-its-history-treatment-and-ramifications-for-users-and-their-families
#8
Douglas Greg Gordon, Gideon de Jong
It is now well-established that Australia has a significant issue with methamphetamine. Recent dramatic changes in manufacturing have led to significant shifts in both the patterns of use and the relative purity of this illicit drug, with the crystalline form of methamphetamine commonly referred to as 'ice'. Excessive use not only impacts on those taking the drug, but also takes a heavy toll on their families. With few effective treatment options currently available, there is a strong focus on developing replacement pharmacotherapies and examining the efficacy of outpatient counselling and residential treatment options...
June 5, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29860806/-new-psychoactive-substances-abuse-among-patients-with-access-to-methadone-maintenance-treatment-in-jiangsu-province-a-case-control-study
#9
Z Cheng, G H Chen, M M Dai, W Luo, P Lyu, X B Cao
Objective: To explore the reasons and factors associated with new psychoactive substances abuse among patients with access to methadone maintenance treatment (MMT). Methods: A well-developed questionnaire and urine tests were used to collect information about demographic characteristics, condition of MMT and drug abuse, family and social support of MMT clients. A 1∶1 matched case-control study was conducted, and conditional logistic regression model was used to identify factors associated with new psychoactive substances abuse...
May 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29860057/varenicline-treatment-for-methamphetamine-dependence-a-randomized-double-blind-phase-ii-clinical-trial
#10
Marisa Briones, Steven Shoptaw, Ryan Cook, Matthew Worley, Aimee-Noelle Swanson, David E Moody, Wenfang B Fang, John Tsuang, Benjamin Furst, Keith Heinzerling
BACKGROUND: Previous studies have suggested that varenicline, an α4β2 nicotinic receptor partial agonist, and α7 nicotinic receptor full agonist, may be effective for the treatment of methamphetamine (MA) dependence due to dopaminergic effects, relief of glutamatergic and cognitive dysfunction, and activation of nicotinic cholinergic systems. This study aimed to determine if varenicline (1 mg BID) resulted in reduced methamphetamine use compared to placebo among treatment-seeking MA-dependent volunteers...
May 25, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29843429/a-study-on-photostability-of-amphetamines-and-ketamine-in-hair-irradiated-under-artificial-sunlight
#11
Giorgia Miolo, Marianna Tucci, Luca Menilli, Giulia Stocchero, Susanna Vogliardi, Salvatore Scrivano, Massimo Montisci, Donata Favretto
Drugs incorporated into hair are exposed to the environment, and cosmetic and chemical treatments, with possible decreases in their content. Knowledge concerning the effect of sunlight on drug content in hair can be helpful to forensic toxicologists, in particular, when investigating drug concentrations above or below pre-determined cut-offs. Twenty authentic positive hair samples were selected which had previously tested positive for amphetamines and/or ketamine. Washed hair were divided into two identical strands, with the former exposed at 765 W/m² (300⁻800 nm spectrum of irradiance) for 48 h in a solar simulator, and the latter kept in the dark...
May 28, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29796230/the-effects-of-vitamin-b-12-on-the-brain-damages-caused-by-methamphetamine-in-mice
#12
Mohammad Moshiri, Seyed Mojtaba Hosseiniyan, Seyed Adel Moallem, Farzin Hadizadeh, Amir Hossein Jafarian, Ameneh Ghadiri, Toktam Hoseini, Mahmoud Seifi, Leila Etemad
Objectives: Methamphetamine (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH's neurodegenerative changes. Materials and Methods: Two groups of 6 animals received METH (10 mg/kg, interaperitoneally (IP)) four times with a 2 hr interval. Thirty mins before METH administration, vit B12 (1 mg/kg) or normal saline were injected IP...
April 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29763685/autophagy-plays-a-pro-survival-role-against-methamphetamine-induced-apoptosis-in-h9c2-cells
#13
Chao Zhao, Yong Mei, Xufeng Chen, Lei Jiang, Yunfei Jiang, Xu Song, Hang Xiao, Jun Wang, Jingsong Zhang
Methamphetamine (METH) is a commonly abused psychostimulant that can induce severe neurotoxicity. Cardiovascular injury caused by METH has recently gained increasing attention; however, the underlying mechanisms remain unclear. As autophagy has been shown to be associated with cell injury, the association between autophagy and METH-mediated cell apoptosis was investigated in the present study. METH treatment significantly increased the expression of two key autophagy proteins, i.e., Beclin-1 and LC3-II, in the cardiomyocyte cell line H9C2...
May 12, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29756302/velopharyngeal-dysfunction-from-intranasal-substance-abuse-case-series-and-review-of-literature
#14
Peng You, Linda Chow, Anne Dworschak-Stokan, Murad Husein
OBJECTIVE: Intranasal substance abuse with cocaine or opioids can result in complications involving the midline nasal and oral structures. When the defect involves the velopharyngeal musculature, this leads to velopharyngeal dysfunction (VPD). This article aims to illustrate this clinical entity through a series of four patients and a review of the literature. METHODS: A series of four cases of VPD due to intranasal narcotic use and their management are discussed...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29754597/re-wired-treatment-and-peer-support-for-men-who-have-sex-with-men-who-use-methamphetamine
#15
Kent Burgess, Garth Parkhill, Jeremy Wiggins, Simon Ruth, Mark Stoovè
Background This paper examines a methamphetamine treatment and peer support program for gay men and other men who have sex with men (MSM) who use methamphetamine. Australian MSM use illicit drugs including methamphetamine at significantly higher rates than the broader community.1,2 Methamphetamine rates are higher again amongst HIV positive MSM. Methamphetamine in the MSM community is associated with sexual activity and may be associated with psychosocial harms including risk of the transmission of HIV and sexually transmissible infections...
April 2018: Sexual Health
https://www.readbyqxmd.com/read/29731519/development-of-intensive-motivational-interviewing-imi-and-modifications-for-treating-women-with-alcohol-use-disorders
#16
Douglas L Polcin, Rachael Korcha, Madhabika Nayak
Women have greater vulnerability to alcohol problems than men. They become intoxicated after drinking half as much as men, develop cirrhosis of the liver more rapidly, and have a greater risk of dying from alcohol-related accidents. Despite more serious consequences related to their drinking, treatment for women with alcohol use disorders has been understudied relative to treatment for men. Intensive motivational interviewing (IMI) is a recent psychotherapeutic intervention for substance abuse problems that draws on the principles of brief motivational interviewing (1-2 session)...
June 2018: Journal of Contemporary Psychotherapy
https://www.readbyqxmd.com/read/29727969/contamination-profiles-mass-loadings-and-sewage-epidemiology-of-neuropsychiatric-and-illicit-drugs-in-wastewater-and-river-waters-from-a-community-in-the-midwestern-united-states
#17
Allie J Skees, Katelyn S Foppe, Bommanna Loganathan, Bikram Subedi
In this study, residues of the neuropsychiatric and illicit drugs including stimulants, opioids, hallucinogens, antischizophrenics, sedatives, and antidepressants were determined in influent and effluent samples from a small wastewater treatment plant, a receiving creek, and river waters in the Four Rivers region of the Midwestern United States. Nineteen neuropsychiatric drugs, eight illicit drugs, and three metabolites of illicit drugs were detected and quantitated in the water samples using HPLC-MS/MS. Residual concentrations of the drugs varied from below the detection limit to sub-μg/L levels...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29718879/methamphetamine-consumption-and-life-threatening-abdominal-complications-a-case-report
#18
Xiaojing Zou, Haiyan Huang, Le Yang, Hong Liu, Yongfeng Li, Qin Xia, Shiying Yuan, Shanglong Yao
RATIONALE: Methamphetamine (METH) abuse is increasing rapidly all over the world and becoming a significant public health concern in China. However, abdominal complications secondary to METH abuse are usually overlooked. We describe an unusual case of gangrenous cholecystitis and small intestinal ischemia due to METH abuse. PATIENT CONCERNS: In this report, a 44-year-old male patient with abdominal pain and hematochezia has a history of crystal meth abuse. DIAGNOSIS: The patient was diagnosed as septic shock, paralytic ileus, gangrenous cholecystitis, and small intestinal ischemia due to METH abuse based on computed tomography (CT) scan, endoscopy examination, laparotomy, and pathology...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29715654/relationship-between-the-duration-of-methamphetamine-use-and-psychotic-symptoms-a-two-year-prospective-cohort-study
#19
Jun Ma, Xiao-Dong Li, Tong-Yu Wang, Su-Xia Li, Shi-Qiu Meng, Frederic C Blow, Mark Ilgen, Louisa Degenhardt, Julia Lappin, Ping Wu, Jie Shi, Yan-Ping Bao, Lin Lu
BACKGROUND: Psychosis is a key harm associated with methamphetamine (MA) use. This study examined the relationship between the duration of MA use and risk of psychotic symptoms. METHODS: A cohort of 528 individuals with chronic MA use was followed for two years after leaving treatment center in Guangdong, China. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale at baseline and four follow-up visits (6, 12, 18 and 24 months after baseline)...
April 22, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29715538/age-and-sex-dependent-effects-of-methamphetamine-on-cognitive-flexibility-and-5-ht-2c-receptor-localization-in-the-orbitofrontal-cortex-of-sprague-dawley-rats
#20
Emily R Hankosky, Sara R Westbrook, Rachel M Haake, Jari Willing, Lori T Raetzman, Janice M Juraska, Joshua M Gulley
Adolescents and females experience worse outcomes of drug use compared to adults and males. This could result from age- and sex-specific consequences of drug exposure on brain function and cognitive behavior. In the current study, we examined whether a history of intravenous methamphetamine (METH) self-administration impacted cognitive flexibility and 5-HT2C R localization in the orbitofrontal cortex (OFC) in an age- and sex-dependent manner. Strategy shifting was assessed in male and female Sprague-Dawley rats that had self-administered METH (0...
April 28, 2018: Behavioural Brain Research
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