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https://www.readbyqxmd.com/read/28092450/preintervention-profiles-of-information-motivational-and-behavioral-self-efficacy-for-methamphetamine-use-and-hiv-medication-adherence-among-gay-and-bisexual-men
#1
Tyrel J Starks, Brett M Millar, Jonathan M Lassiter, Jeffrey T Parsons
Although rates of crystal methamphetamine use in the United States have fallen from their peak in the mid-2000s, use remains a major public health concern, which disproportionately affects gay and bisexual men (GBM). It poses a particular challenge for HIV-positive men, for whom it has been linked to medication adherence problems as well as compromised immune function. Although the information, motivation, and behavioral skills (IMB) model has been widely used to conceptualize health behavior, little is known about GBM's initial levels of information, motivation, and behavioral self-efficacy to improve HIV medication adherence and to reduce crystal methamphetamine use at the outset of treatment...
January 16, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28073060/acute-behavioral-effects-of-co-administration-of-mephedrone-and-mdma-in-mice
#2
Barbara Budzynska, Agnieszka Michalak, Małgorzata Frankowska, Katarzyna Kaszubska, Grażyna Biała
BACKGROUND: Abuse of more than one psychoactive drug is becoming a global problem. Our experiments were designed to examine the effects of a concomitant administration of 3,4-methylenedioxy-methamphetamine (MDMA) and mephedrone on depression- and anxiety-like behaviors and cognitive processes in Swiss mice. METHODS: In order to investigate the drug interactions the forced swimming test (FST) - an animal model of depression, the passive avoidance (PA) test - a memory and learning paradigm, as well as the elevated plus maze (EPM) test - test for anxiety level were used...
October 11, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28068828/key-differences-in-treatment-seeking-stimulant-users-attending-a-specialised-treatment-service-a-means-of-early-intervention
#3
Shalini Arunogiri, Margret Petrie, Michelle Sharkey, Dan I Lubman
OBJECTIVES: Few people who use stimulants seek clinical treatment. This study sought to describe a cohort of stimulant users who attended a stimulant-specific treatment service, Access Point, in Melbourne, Australia between 2008 and 2014. METHODS: A retrospective audit of the records of adults ( n = 175) who sought treatment for stimulant use at a stimulant-specific outpatient treatment service was conducted. RESULTS: Service users had a median age of 32 (range = 19-54)...
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28063946/the-abuse-potential-of-two-novel-synthetic-cathinones-with-modification-on-the-alpha-carbon-position-2-cyclohexyl-2-methylamino-1-phenylethanone-machp-and-2-methylamino-1-phenyloctan-1-one-maop-and-their-effects-on-dopaminergic-activity
#4
Chrislean Jun Botanas, Seong Shoon Yoon, June Bryan de la Peña, Irene Joy Dela Peña, Mikyung Kim, Taeseon Woo, Joung-Wook Seo, Choon-Gon Jang, Kyung-Tae Park, Young Hun Lee, Yong Sup Lee, Hee Jin Kim, Jae Hoon Cheong
The recreational use of synthetic cathinones has dramatically increased in recent years, which is partly due to easy accessibility and ability of synthetic cathinones to exert rewarding effects similar to cocaine and methamphetamine. Many synthetic cathinones have already been scheduled in several countries; however, novel and diverse synthetic cathinones are emerging at an unprecedented rate, often outpacing regulatory processes. Recently, designer modifications of the basic cathinone molecule are usually performed on the alpha-carbon position...
January 4, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28057490/blockade-of-patch-based-%C3%AE-opioid-receptors-in-the-striatum-attenuates-methamphetamine-induced-conditioned-place-preference-and-reduces-activation-of-the-patch-compartment
#5
Kristen A Horner, Mary Caroline Logan, Trevor J Fisher, Jordan B Logue
The behavioral effects of methamphetamine (METH) are mediated by the striatum, which is divided into the patch compartment, which mediates limbic and reward functions, and the matrix compartment, which mediates sensorimotor tasks. METH treatment results in repetitive behavior that is related to enhanced relative activation of the patch versus the matrix compartment. The patch, but not the matrix compartment contains a high density of μ opioid receptors, and localized blockade of patch-based μ opioid receptors attenuates METH-induced patch-enhanced activity and repetitive behaviors...
January 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28051103/maladaptive-sex-behavior-following-concurrent-methamphetamine-and-sexual-experience-in-male-rats-is-associated-with-altered-neural-activity-in-frontal-cortex
#6
Lindsey B Kuiper, Karla S Frohmader, Lique M Coolen
The use of psychostimulants is often associated with hypersexuality, and psychostimulant users have identified the effects of drug on sexual behavior as a reason for further use. It was previously demonstrated that methamphetamine (Meth), when administered concurrently with sexual behavior show impairment of inhibition of sexual behavior in a conditioned sex aversion (CSA) paradigm where mating is paired with illness. This is indicative of maladaptive sex behavior following Meth and sex experience. The present study examined the neural pathways activated during inhibition of sexual behavior and the effects of concurrent Meth and sexual behavior on neural activity in these pathways, using ERK phosphorylation (pERK) as neural activity marker...
January 4, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28028601/voluntary-inhalation-of-methamphetamine-a-novel-strategy-for-studying-intake-non-invasively
#7
C Juarez-Portilla, R D Kim, M Robotham, M Tariq, M Pitter, J LeSauter, R Silver
RATIONALE: The abuse of the psychostimulant methamphetamine (MA) is associated with substantial costs and limited treatment options. To understand the mechanisms that lead to abuse, animal models of voluntary drug intake are crucial. OBJECTIVES: We aimed to develop a protocol to study long-term non-invasive voluntary intake of MA in mice. METHODS: Mice were maintained in their home cages and allowed daily 1 h access to an attached tunnel leading to a test chamber in which nebulized MA was available...
December 27, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/28008351/methamphetamine-addiction-potential-substitute-treatment
#8
Florence Levy
No abstract text is available yet for this article.
December 2016: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28008256/blonanserin-treatment-in-patients-with-methamphetamine-induced-psychosis-comorbid-with-intellectual-disabilities
#9
Kosuke Okazaki, Manabu Makinodan, Kazuhiko Yamamuro, Tomoyo Takata, Toshifumi Kishimoto
OBJECTIVE: Methamphetamine (MA) use has recently been associated with high levels of psychiatric hospitalization and serious social dysfunction. MA use causes frequent psychotic symptoms, which can be treated with antipsychotics. However, people with intellectual disabilities (ID) are vulnerable to adverse effects resulting from treatment with antipsychotic medications. METHOD: We report two cases of MA-induced psychosis (MAP) in patients with ID who were treated with the antipsychotic blonanserin...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28006940/does-effect-from-developmental-methamphetamine-exposure-on-spatial-learning-and-memory-depend-on-stage-of-neuroontogeny
#10
I Hrebíčková, M Ševčíková, K Nohejlová, R Šlamberová
Psychostimulants, including methamphetamine (MA), have neurotoxic effect, especially, if they are targeting CNS during its critical periods of development. The present study was aimed to examine cognitive changes after prenatal and neonatal MA treatment in combination with chronic MA exposure in adulthood of male rats. Eight groups of male rats were tested in adulthood: males whose mothers were exposed to MA (5 mg/kg) or saline (SA, 1 ml/kg) during the first half of gestation period (GD 1-11), the second half of gestation period (GD 12-22) and neonatal period (PD 1-11)...
December 22, 2016: Physiological Research
https://www.readbyqxmd.com/read/27993694/effects-of-chronic-methamphetamine-on-psychomotor-and-cognitive-functions-and-dopamine-signaling-in-the-brain
#11
Panayotis K Thanos, Ronald Kim, Foteini Delis, Mark J Rocco, Jacob Cho, Nora D Volkow
Methamphetamine (MA) studies in animals usually involve acute, binge, or short-term exposure to the drug. However, addicts take substantial amounts of MA for extended periods of time. Here we wished to study the effects of MA exposure on brain and behavior, using an animal model analogous to this pattern of MA intake. MA doses, 4 and 8mg/kg/day, were based on previously reported average daily freely available MA self-administration levels. We examined the effects of 16 week MA treatment on psychomotor and cognitive function in the rat using open field and novel object recognition tests and we studied the adaptations of the dopaminergic system, using in vitro and in vivo receptor imaging...
March 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27990591/on-the-role-of-imitation-on-adolescence-methamphetamine-abuse-dynamics
#12
J Mushanyu, F Nyabadza, G Muchatibaya, A G R Stewart
Adolescence methamphetamine use is an issue of considerable concern due to its correlation with later delinquency, divorce, unemployment and health problems. Understanding how adolescents initiate methamphetamine abuse is important in developing effective prevention programs. We formulate a mathematical model for the spread of methamphetamine abuse using nonlinear ordinary differential equations. It is assumed that susceptibles are recruited into methamphetamine use through imitation. An epidemic threshold value, [Formula: see text], termed the abuse reproduction number, is proposed and defined herein in the drug-using context...
December 18, 2016: Acta Biotheoretica
https://www.readbyqxmd.com/read/27989838/opioid-gene-expression-changes-and-post-translational-histone-modifications-at-promoter-regions-in-the-rat-nucleus-accumbens-after-acute-and-repeated-3-4-methylenedioxy-methamphetamine-mdma-exposure
#13
Francesca Felicia Caputi, Martina Palmisano, Lucia Carboni, Sanzio Candeletti, Patrizia Romualdi
The recreational drug of abuse 3,4-methylenedioxymethamphetamine (MDMA) has been shown to produce neurotoxic damage and long-lasting changes in several brain areas. In addition to the involvement of serotoninergic and dopaminergic systems, little information exists about the contribution of nociceptin/orphaninFQ (N/OFQ)-NOP and dynorphin (DYN)-KOP systems in neuronal adaptations evoked by MDMA. Here we investigated the behavioral and molecular effects induced by acute (8mg/kg) or repeated (8mg/kg twice daily for seven days) MDMA exposure...
October 29, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27986974/effects-of-a-serotonin-2c-agonist-and-a-2a-antagonist-on-actigraphy-based-sleep-parameters-disrupted-by-methamphetamine-self-administration-in-rhesus-monkeys
#14
Maylen Perez Diaz, Monica L Andersen, Kenner C Rice, Leonard L Howell
Sleep disorders and substance abuse are highly comorbid and we have previously shown that methamphetamine self-administration significantly disrupts activity-based sleep parameters in rhesus monkeys. To the best of our knowledge, no study has evaluated the effectiveness of any pharmacological intervention to attenuate the effects of methamphetamine on nighttime activity under well-controlled conditions in laboratory animals. Thus, we examined the effects of a 5-HT2C receptor agonist, WAY163909, and a 5-HT2A receptor antagonist, M100907, given alone and in combination, on actigraphy-based sleep parameters disrupted by methamphetamine self-administration in non-human primates...
January 18, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27940387/beyond-methamphetamine-documenting-the-implementation-of-the-matrix-model-of-substance-use-treatment-for-opioid-users-in-a-south-african-setting
#15
Jessica F Magidson, Hetta Gouse, Warren Burnhams, Christie Y Y Wu, Bronwyn Myers, John A Joska, Adam W Carrico
INTRODUCTION: The Matrix model of substance use treatment has been evaluated extensively in the United States as an effective treatment for methamphetamine use disorders. Since 2007, the Matrix model has been implemented in Cape Town, South Africa, where one in four treatment-seeking individuals are primarily opioid rather than stimulant users. Yet, there has been limited data on the application of the Matrix model for other types of substance use disorders in a resource-limited setting...
March 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27936284/utility-of-preclinical-drug-versus-food-choice-procedures-to-evaluate-candidate-medications-for-methamphetamine-use-disorder
#16
Matthew L Banks
Substance use disorders are diagnosed as a manifestation of inappropriate behavioral allocation toward abused drugs and away from other behaviors maintained by more adaptive nondrug reinforcers (e.g., money and social relationships). Substance use disorder treatment goals include not only decreasing drug-maintained behavior but also promoting behavioral reallocation toward these socially adaptive alternative reinforcers. Preclinical drug self-administration procedures that offer concurrent access to both drug and nondrug reinforcers provide a translationally relevant dependent measure of behavioral allocation that may be useful for candidate medication evaluation...
December 9, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27933960/novel-and-high-affinity-2-diphenylmethyl-sulfinyl-acetamide-modafinil-analogues-as-atypical-dopamine-transporter-inhibitors
#17
Jianjing Cao, Rachel D Slack, Oluyomi M Bakare, Caitlin Burzynski, Rana Rais, Barbara S Slusher, Theresa Kopajtic, Alessandro Bonifazi, Michael P Ellenberger, Hideaki Yano, Yi He, Guo-Hua Bi, Zheng-Xiong Xi, Claus J Loland, Amy Hauck Newman
The development of pharmacotherapeutic treatments of psychostimulant abuse has remained a challenge, despite significant efforts made toward relevant mechanistic targets, such as the dopamine transporter (DAT). The atypical DAT inhibitors have received attention due to their promising pharmacological profiles in animal models of cocaine and methamphetamine abuse. Herein, we report a series of modafinil analogues that have an atypical DAT inhibitor profile. We extended SAR by chemically manipulating the oxidation states of the sulfoxide and the amide functional groups, halogenating the phenyl rings, and/or functionalizing the terminal nitrogen with substituted piperazines, resulting in several novel leads such as 11b, which demonstrated high DAT affinity (Ki = 2...
December 8, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27930896/can-anxiety-tested-in-the-elevated-plus-maze-be-related-to-nociception-sensitivity-in-adult-male-rats
#18
Marie Pometlová, Anna Yamamotová, Kateryna Nohejlová, Romana Šlamberová
Methamphetamine (MA) is one of the most addictive psychostimulant drugs with a high potential for abuse. Our previous studies demonstrated that MA administered to pregnant rats increases pain sensitivity and anxiety in their adult offspring and makes them more sensitive to acute administration of the same drug in adulthood. Because individuals can differ considerably in terms of behaviour and physiology, such as rats that do not belong in some characteristics (e.g. anxiety) to average, can be described as low-responders or high-responders, are then more or less sensitive to pain...
2016: Prague Medical Report
https://www.readbyqxmd.com/read/27927042/pharmacological-treatments-for-methamphetamine-addiction-current-status-and-future-directions
#19
Javier Ballester, Gerald Valentine, Mehmet Sofuoglu
Methamphetamine (MA) abuse remains a global health challenge despite intense research interest in the development of pharmacological treatments. This review provides a summary of clinical trials and human studies on the pharmacotherapy of methamphetamine use disorder (MUD). Areas covered: We summarize published clinical trials that tested candidate medications for MUD and also conducted PubMed and Google Scholar searches to identify recently completed clinical trials using the keywords 'methamphetamine' 'addiction' 'pharmacotherapy' and 'clinical trial...
December 20, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27919412/anti-nmda-a-nmdar-receptor-encephalitis-related-to-acute-consumption-of-metamphetamine-relevance-of-differential-diagnosis
#20
O Iriondo, J Zaldibar-Gerrikagoitia, T Rodríguez, J M García, L Aguilera
A 19-year-old male came to the Emergency Room of our hospital due to an episode of dystonic movements and disorientation 4 days after consuming methamphetamine, which evolved to a catatonic frank syndrome and eventually to status epilepticus. Definitive diagnosis was anti-NMDA receptor encephalitis, an acute inflammation of the limbic area of autoimmune origin in which early diagnosis and treatment are key elements for the final outcome. In this case, initial normal tests and previous methamphetamine poisoning delayed diagnosis, because inhaled-methamphetamine poisoning causes similar clinical symptoms to anti-NMDA receptor encephalitis...
December 2, 2016: Revista Española de Anestesiología y Reanimación
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