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JOURNAL ARTICLE
Da Ren, Wei Li, Ruijiang Zeng, Xinlin Liu, Huaiyuan Liang, Wei Xiong, Chunguang Yang, Xin Jin
RB transcriptional corepressor 1 (RB) deletion is the most important genomic factor associated with the prognosis of castration-resistant prostate cancer (CRPC) patients receiving androgen receptor (AR) signaling inhibitor therapy. Loss of RB could support prostate cancer cell growth in a hormone-independent manner, but the underlying mechanism by which RB regulates tumor progression extends far beyond the cell cycle pathway. A previous study indicated that RB inactivates AKT signaling but has no effect on mTOR signaling in cancer cells...
March 21, 2024: Cell Death and Differentiation
#2
JOURNAL ARTICLE
Maria Vega-Sendino, Felipe F Lüttmann, Teresa Olbrich, Yanpu Chen, Carsten Kuenne, Paula Stein, Desiree Tillo, Grace I Carey, Jiasheng Zhong, Virginia Savy, Lenka Radonova, Tianlin Lu, Bechara Saykali, Kee-Pyo Kim, Catherine N Domingo, Leah Schüler, Stefan Günther, Mette Bentsen, Darko Bosnakovski, Hans Schöler, Michael Kyba, Tapan K Maity, Lisa M Jenkins, Mario Looso, Carmen J Williams, Johnny Kim, Sergio Ruiz
In mice, exit from the totipotent two-cell (2C) stage embryo requires silencing of the 2C-associated transcriptional program. However, the molecular mechanisms involved in this process remain poorly understood. Here we demonstrate that the 2C-specific transcription factor double homeobox protein (DUX) mediates an essential negative feedback loop by inducing the expression of DUXBL to promote this silencing. We show that DUXBL gains accessibility to DUX-bound regions specifically upon DUX expression. Furthermore, we determine that DUXBL interacts with TRIM24 and TRIM33, members of the TRIM superfamily involved in gene silencing, and colocalizes with them in nuclear foci upon DUX expression...
March 20, 2024: Nature Genetics
#3
JOURNAL ARTICLE
Qian Du, Lei Zhu, Jianhui Zhong, Xueqi Wei, Qi Zhang, Tengfei Shi, Cong Han, Xinhuan Yin, Xingqi Chen, Dewen Tong, Yong Huang
The mechanism of genome DNA replication in circular single-stranded DNA viruses is currently a mystery, except for the fact that it undergoes rolling-circle replication. Herein, we identified SUMOylated porcine nucleophosmin-1 (pNPM1), which is previously reported to be an interacting protein of the viral capsid protein, as a key regulator that promotes the genome DNA replication of porcine single-stranded DNA circovirus. Upon porcine circovirus type 2 (PCV2) infection, SUMO2/3 were recruited and conjugated with the K263 site of pNPM1's C-terminal domain to SUMOylate pNPM1, subsequently, the SUMOylated pNPM1 were translocated in nucleoli to promote the replication of PCV2 genome DNA...
February 23, 2024: PLoS Pathogens
#4
Hui Wang, Timothy S Chang, Beth A Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C Van Swieten, Elise Dopper, Bernardino F Ghetti, Kathy L Newell, Claire Troakes, Justo G de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H Oertel, Gesine Respondek, Thomas Arzberger, Sigrun Roeber, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G Beach, Geidy E Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A Ross, Douglas Galasko, Adam L Boxer, Bruce L Miller, Willian W Seeley, Vivanna M Van Deerlin, Charles L White, Huw Morris, Rohan de Silva, John F Crary, Alison M Goate, Jeffrey S Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C Naj, Li-San Wang, Dennis W Dickson, Günter U Höglinger, Gerard D Schellenberg, Daniel H Geschwind, Wan-Ping Lee
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. We performed whole genome sequencing (WGS) and conducted association analysis for single nucleotide variants (SNVs), small insertions/deletions (indels), and structural variants (SVs) in a cohort of 1,718 individuals with PSP and 2,944 control subjects. Analysis of common SNVs and indels confirmed known genetic loci at MAPT , MOBP , S TX6 , SLCO1A2 , DUSP10 , and SP1 , and also uncovered novel signals in APOE , FCHO1/MAP1S, KIF13A, TRIM24, TNXB, and ELOVL1 ...
December 30, 2023: medRxiv
#5
JOURNAL ARTICLE
Huai Liu, Ling Tang, Sha Gong, Tengfei Xiao, Hongmin Yang, Wangning Gu, Hui Wang, Pan Chen
Reprogramming of macrophages toward an M1 phenotype is a novel strategy to induce anticancer immunity. However, the regulatory mechanisms of M1 macrophage polarization and its functional roles in nasopharyngeal carcinoma (NPC) progression need to be further explored. Here we found that SPLUNC1 was highly expressed and responsible for M1 macrophage polarization. JAK/STATs pathway activation was involved in SPLUNC1-mediated M1 macrophage polarization. Importantly, regulation of SPLUNC1 in macrophages affected CM-mediated influence on NPC cell proliferation and migration...
December 21, 2023: Cell Death & Disease
#6
JOURNAL ARTICLE
Mateusz Kciuk, Martyna Malinowska, Adrianna Gielecińska, Rajamanikandan Sundaraj, Somdutt Mujwar, Anna Zawisza, Renata Kontek
Multicomponent reactions have emerged as an important approach for the synthesis of diverse and complicated chemical compounds. They have various advantages over two-component reactions, including the convenience of one-pot procedures and the ability to modify the structure of agents. Here, we employed in vitro and in silico studies to explore the anticancer potential of novel aminobenzylnaphthols derived from the Betti reaction ( MMZ compounds). MTT assay was used to explore the cytotoxic activity of the compounds in pancreatic (BxPC-3 cells) and colorectal (HT-29) cancer cell lines or normal human lung fibroblasts (WI-38 cells)...
October 23, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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JOURNAL ARTICLE
Liyan Yue, Qiaojing Jia, Jinhui Dong, Jianxing Wang, Xiumin Ren, Ou Xu
PURPOSE: Allergic rhinitis (AR) is a T helper type 2 (Th2)-mediated inflammatory disease. The E3 ligase tripartite motif-containing 24 (TRIM24) regulates the recruitment of acetyltransferase CREB-binding protein (CBP) to signal transducer and activator of transcription 6 (STAT6). CBP mediates the acetylation of STAT6 and decreases its activity. To date, the precise role of TRIM24 in AR has not been fully interpreted. Herein, our study aimed to explore the functions of TRIM24 in AR. METHODS: The expression of TRIM24 in peripheral blood mononuclear cells (PBMCs) and CD4+ T cells from patients with AR was measured...
September 2023: Allergy, Asthma & Immunology Research
#8
EDITORIAL
Seung Koo Yang, Doo Hee Han
No abstract text is available yet for this article.
September 2023: Allergy, Asthma & Immunology Research
#9
JOURNAL ARTICLE
Weiye Qian, Zhiyuan Yang
The emergence of single-cell RNA sequencing (scRNA-seq) technology makes it possible to measure DNA, RNA, and protein in a single cell. Cellular Indexing of Transcriptomes and Epitopes by sequencing (CITE-seq) is a powerful multimodal single-cell research innovation, allowing researchers to capture RNA and surface protein expression on the same cells. Currently, identification of cell-type-specific genes in CITE-seq data is still challenging. In this study, we obtained a set of CITE-seq datasets from Kaggle database, which included the sequencing dataset of seven cell types during bone marrow stem cell differentiation...
September 16, 2023: Computers in Biology and Medicine
#10
Lifa Huang, Xu Li, Hui Ye, Yajun Liu, Xiaolong Liang, Chao Yang, Lin Hua, Zhaoxian Yan, Xin Zhang
No abstract text is available yet for this article.
September 21, 2023: Journal of Experimental & Clinical Cancer Research: CR
#11
JOURNAL ARTICLE
Riley M Horvath, Ivan Sadowski
HIV-1 provirus expression is controlled by signaling pathways that are responsive to T cell receptor engagement, including those involving Ras and downstream protein kinases. The induction of transcription from the HIV-1 LTR in response to Ras signaling requires binding of the Ras-responsive element binding factor (RBF-2) to conserved cis elements flanking the enhancer region, designated RBE3 and RBE1. RBF-2 is composed minimally of the USF1, USF2, and TFII-I transcription factors. We recently determined that TFII-I regulates transcriptional elongation from the LTR through recruitment of the co-activator TRIM24...
June 28, 2023: Viruses
#12
JOURNAL ARTICLE
A Functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes.
Laura Schubert, Anh T Le, Trista K Hinz, Andre C Navarro, Sarah K Nelson-Taylor, Raphael A Nemenoff, Lynn E Heasley, Robert C Doebele
CRISPR/Cas9 gene editing represents a powerful tool for investigating fusion oncogenes in cancer biology. Successful experiments require that sgRNAs correctly associate with their target sequence and initiate double stranded breaks which are subsequently repaired by endogenous DNA repair systems yielding fusion chromosomes. Simple tests to ensure sgRNAs are functional are not generally available and often require single cell cloning to identify successful CRISPR-editing events. Here, we describe a novel method relying on acquisition of IL3-independence in Ba/F3 cells to identify sgRNA pairs that generate oncogenic gene rearrangements of the Ret and Ntrk1 tyrosine kinases...
July 20, 2023: Biology Open
#13
JOURNAL ARTICLE
Qiqi Shi, Bo Yu, Yingwen Zhang, Yi Yang, Chenxin Xu, Mingda Zhang, Guoyu Chen, Fei Luo, Bowen Sun, Ru Yang, Yanxin Li, Haizhong Feng
PURPOSE: High-risk neuroblastoma (NB) still has an unfavorable prognosis and inducing NB differentiation is a potential strategy in clinical treatment, yet underlying mechanisms are still elusive. Here we identify TRIM24 as an important regulator of NB differentiation. METHODS: Multiple datasets and clinical specimens were analyzed to define the role of TRIM24 in NB. The effects of TRIM24 on differentiation and growth of NB were determined by cell morphology, spheres formation, soft agar assay, and subcutaneous xenograft in nude mice...
July 19, 2023: Cellular Oncology (Dordrecht)
#14
JOURNAL ARTICLE
Lalit R Patel, Sabrina A Stratton, Megan McLaughlin, Patrick Krause, Kendra Allton, Andrés López Rivas, Daniela Barbosa, Traver Hart, Michelle C Barton
TRIM24 is an oncogenic chromatin reader that is frequently overexpressed in human tumors and associated with poor prognosis. However, TRIM24 is rarely mutated, duplicated, or rearranged in cancer. This raises questions about how TRIM24 is regulated and what changes in its regulation are responsible for its overexpression. Here, we perform a genome-wide CRISPR-Cas9 screen by fluorescence-activated cell sorting (FACS) that nominated 220 negative regulators and elucidated a regulatory network that includes the KAP1 corepressor, CNOT deadenylase, and GID/CTLH E3 ligase...
July 21, 2023: IScience
#15
JOURNAL ARTICLE
Carlos F De La Cruz-Herrera, Michael H Tatham, Umama Z Siddiqi, Kathy Shire, Edyta Marcon, Jack F Greenblatt, Ronald T Hay, Lori Frappier
SUMO modifications regulate the function of many proteins and are important in controlling herpesvirus infections. We performed a site-specific proteomic analysis of SUMO1- and SUMO2-modified proteins in Epstein-Barr virus (EBV) latent and lytic infection to identify proteins that change in SUMO modification status in response to EBV reactivation. Major changes were identified in all three components of the TRIM24/TRIM28/TRIM33 complex, with TRIM24 being rapidly degraded and TRIM33 being phosphorylated and SUMOylated in response to EBV lytic infection...
July 2023: PLoS Pathogens
#16
JOURNAL ARTICLE
Luke Isbel, Murat Iskar, Sevi Durdu, Joscha Weiss, Ralph S Grand, Eric Hietter-Pfeiffer, Zuzanna Kozicka, Alicia K Michael, Lukas Burger, Nicolas H Thomä, Dirk Schübeler
The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are unusually diverse with regard to their chromatin features, including histone modifications, raising the possibility that the local chromatin environment can contextualize p53 regulation. Here, we show that epigenetic characteristics of closed chromatin, such as DNA methylation, do not influence the binding of p53 across the genome. Instead, the ability of p53 to open chromatin and activate its target genes is locally restricted by its cofactor Trim24...
June 29, 2023: Nature Structural & Molecular Biology
#17
JOURNAL ARTICLE
Samuel Bidot, Jun Yin, Pengbo Zhou, Linsheng Zhang, Kristin K Deeb, Geoffrey Smith, Charles E Hill, Joanne Xiu, Mehmet A Bilen, Katherine B Case, Mazie Tinsley, Bradley Carthon, Lara R Harik
CONTEXT.—: Genetic profiling data of prostatic adenocarcinoma are derived from predominantly White patients. In African Americans, prostatic adenocarcinoma has a poorer prognosis, raising the possibility of distinct genetic alterations. OBJECTIVE.—: To investigate the genomic alterations of prostatic adenocarcinoma metastatic to regional lymph nodes in African American patients, with an emphasis on SPOP mutation. DESIGN.—: We retrospectively reviewed African American patients with pN1 prostatic adenocarcinoma managed with radical prostatectomy and lymph node dissection...
June 19, 2023: Archives of Pathology & Laboratory Medicine
#18
JOURNAL ARTICLE
Zhaoyuan Hui, Yuanzheng Fu, Yunyun Chen, Jie Yin, Hui Fang, Yifan Tu, Ying Gu, Jiawei Zhang
BACKGROUND: As an anti-inflammatory cytokine, interleukin 10 (IL-10) plays a vital role in preventing inflammatory and autoimmune pathologies while also maintaining immune homeostasis. IL-10 production in macrophages is tightly regulated by multiple pathways. TRIM24, a member of the Transcriptional Intermediary Factor 1 (TIF1) family, contributes to antiviral immunity and macrophage M2 polarization. However, the role of TRIM24 in regulating IL-10 expression and its involvement in endotoxic shock remains unclear...
June 16, 2023: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
#19
JOURNAL ARTICLE
Javier Perez-Garcia, Antonio Espuela-Ortiz, José M Hernández-Pérez, Ruperto González-Pérez, Paloma Poza-Guedes, Elena Martin-Gonzalez, Celeste Eng, Olaia Sardón-Prado, Elena Mederos-Luis, Paula Corcuera-Elosegui, Inmaculada Sánchez-Machín, Javier Korta-Murua, Jesús Villar, Esteban G Burchard, Fabian Lorenzo-Diaz, Maria Pino-Yanes
BACKGROUND: The upper-airway microbiome is involved in asthma exacerbations despite inhaled corticosteroid (ICS) treatment. Although human genetics regulates microbiome composition, its influence on asthma-related airway bacteria remains unknown. OBJECTIVE: We aimed to identify genes and biological pathways regulating airway-microbiome traits involved in asthma exacerbations and ICS response. METHODS: Saliva, nasal, and pharyngeal samples from 257 European asthma patients were analyzed...
June 8, 2023: Journal of Allergy and Clinical Immunology
#20
Ishita Bardhan, Soumen Barman, Anirban Roy, Babu Sudhamalla
No abstract text is available yet for this article.
May 31, 2023: Biochemical Journal
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