Junaid Iqbal, Hong-Li Jiang, Hui-Xuan Wu, Long Li, Ying-Hui Zhou, Nan Hu, Fen Xiao, Ting Wang, Shi-Na Xu, Hou-De Zhou
Severe insulin resistance has been linked to some of the most globally prevalent disorders, such as diabetes mellitus, nonalcoholic fatty liver disease, polycystic ovarian syndrome, and hypertension. Hereditary severe insulin resistance syndrome (H-SIRS) is a rare disorder classified into four principal categories: primary insulin receptor defects, lipodystrophies, complex syndromes, and obesity-related H-SIRS. Genes such as INSR , AKT2 , TBC1D4 , AGPAT2 , BSCL2 , CAV1 , PTRF , LMNA , PPARG , PLIN1 , CIDEC , LIPE , PCYT1A , MC4R , LEP , POMC , SH2B1 , RECQL2 , RECQL3 , ALMS1 , PCNT , ZMPSTE24 , PIK3R1 , and POLD1 have been linked to H-SIRS...
September 2023: Genes & Diseases