Luis Alameda, Zhonghua Liu, Pak C Sham, Monica Aas, Giulia Trotta, Victoria Rodriguez, Marta Di Forti, Simona A Stilo, Radhika Kandaswamy, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Bobes, Lieuwe de Haan, Cristina Marta Del-Ben, Charlotte Gayer-Anderson, Lucia Sideli, Peter B Jones, Hannah E Jongsma, James B Kirkbride, Caterina La Cascia, Antonio Lasalvia, Sarah Tosato, Pierre-Michel Llorca, Paulo Rossi Menezes, Jim van Os, Diego Quattrone, Bart P Rutten, Jose Luis Santos, Julio Sanjuán, Jean-Paul Selten, Andrei Szöke, Ilaria Tarricone, Andrea Tortelli, Eva Velthorst, Craig Morgan, Emma Dempster, Eilis Hannon, Joe Burrage, Daniella Dwir, Atheeshaan Arumuham, Jonathan Mill, Robin M Murray, Chloe C Y Wong
Studies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome wide association studies (EWAS) using the Illumina Infinium-Methylation EPIC array in peripheral blood tissue from 366 First-episode of psychosis and 517 healthy controls was performed. Adversity scores were created for abuse, neglect and composite adversity with the Childhood Trauma Questionnaire (CTQ)...
April 17, 2023: Molecular Psychiatry