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Ajay Sheshadri, Dimpy P Shah, Myrna Godoy, Jeremy J Erasmus, Juhee Song, Liang Li, Scott E Evans, Roy F Chemaly, Burton F Dickey, David E Ost
BACKGROUND: Radiologic severity may predict adverse outcomes after lower respiratory tract infection (LRI). However, few studies have quantified radiologic severity of LRIs. We sought to evaluate whether a semi-quantitative scoring tool, the Radiologic Severity Index (RSI), predicted mortality after parainfluenza virus (PIV)-associated LRI. METHODS: We conducted a retrospective review of consecutively-enrolled adult patients with hematologic malignancy or hematopoietic stem cell transplantation and with PIV detected in nasal wash who subsequently developed radiologically-confirmed LRI...
2018: PloS One
Z W Qi, H L Lu, J Zhang, S J Zhang
Objective: To compare the efficacy and safety of omeprazole in the treatment of laryngopharyngeal reflux. Method: One hundred and sixty patients with laryngopharyngeal reflux in our hospital from March 2015 to January 2017 (diagnosis treatment for 8 weeks) were selected and randomly divided into group A, B, C, D, with 40 cases in each group. Each group of patients were treated with omeprazole enteric-coated capsules (20mg, Bid) for 1, 2, 3 and 4 months, respectively. The reflux symptom index(RSI), reflux finding score(RFS) score, and 24h intraesophageal pH-metry , pepsin detection were compared between the four groups before treatment, at the end of treatment, at 1 month and 2 months after treatment...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Jérôme R Lechien, Camille Finck, Mohamad Khalife, Kathy Huet, Véronique Delvaux, Myriam Picalugga, Bernard Harmegnies, Sven Saussez
OBJECTIVE: To assess the usefulness of voice quality measurements as a treatment outcome in patients with laryngopharyngeal reflux (LPR)-related symptoms. DESIGN: Prospective uncontrolled multi-center study. MATERIAL AND METHODS: A total of 80 clinically diagnosed LPR patients with a reflux finding score (RFS)>7 and a reflux symptom index (RSI)>13 were treated with pantoprazole and diet recommendations during 3 or 6 months according to their evolution...
May 16, 2018: Clinical Otolaryngology
Jorge Henrique Santos Saldanha, Mônica Angelim Gomes de Lima, Robson da Fonseca Neves, Jorge Alberto Bernstein Iriart
This study aimed to reveal how metalworkers experience prolonged incapacity for work due to repetitive strain injury/work-related musculoskeletal disorder (RSI/WRMD) and the impact of chronic illness on the construction/deconstruction of masculinity. A qualitative study was performed, based on narrative interviews with male metalworkers in an automotive factory in the State of Bahia, Brazil. The results showed how the conflict in the experience of illness, the maintenance of male identity, and expectations of meeting the rules dictated by hegemonic masculinity are experienced and signified in daily life...
May 10, 2018: Cadernos de Saúde Pública
Ansar Hussain, Xia Li, Yahong Weng, Zhiqin Liu, Muhammad Furqan Ashraf, Ali Noman, Sheng Yang, Muhammad Ifnan, Shanshan Qiu, Yingjie Yang, Deyi Guan, Shuilin He
The WRKY web, which is comprised of a subset of WRKY transcription factors (TFs), plays a crucial role in the regulation of plant immunity, however, the mode of organization and operation of this network remains obscure, especially in non-model plants such as pepper ( Capsicum annuum ). Herein, CaWRKY22 , a member of a subgroup of IIe WRKY proteins from pepper, was functionally characterized in pepper immunity against Ralstonia Solanacearum . CaWRKY22 was found to target the nuclei, and its transcript level was significantly upregulated by Ralstonia Solanacearum inoculation (RSI) and exogenously applied salicylic acid (SA), Methyl jasmonate (MeJA), or ethephon (ETH)...
May 10, 2018: International Journal of Molecular Sciences
Alex J Plajer, Annie L Colebatch, Markus Enders, Álvaro García-Romero, Andrew D Bond, Raúl García-Rodríguez, Dominic S Wright
Difficulties in the preparation of neutral ligands of the type [RSi(2-py)3] (where 2-py is an unfunctionalised 2-pyridyl ring unit) have thwarted efforts to expand the coordination chemistry of ligands of this type. However, simply switching the pyridyl substituents to 6-methyl-pyridyl groups (6-Me-2-py) in the current paper has allowed smooth, high-yielding access to the [PhSi(6-Me-2-py)3] ligand (1), and the first exploration of its coordination chemistry with transition metals. The synthesis, single-crystal X-ray structures and solution dynamics of the new complexes [{PhSi(6-Me-2-py)3}CuCH3CN][PF6], [{PhSi(6-Me-2-py)3}CuCH3CN][CuCl2], [{PhSi(6-Me-2-py)3}FeCl2], [{PhSi(6-Me-2-py)3}Mo(CO)3] and [{PhSi(6-Me-2-py)3}CoCl2] are reported...
May 9, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Muhammad Ifnan Khan, Yangwen Zhang, Zhiqin Liu, Jiong Hu, Cailing Liu, Sheng Yang, Ansar Hussain, Muhammad Furqan Ashraf, Ali Noman, Lei Shen, Xiaoqin Xia, Feng Yang, Deyi Guan, Shuilin He
WRKY transcription factors (TFs) have been implicated in plant growth, development, and in response to environmental cues; however, the function of the majority of pepper WRKY TFs remains unclear. In the present study, we functionally characterized CaWRKY40b , a homolog of AtWRKY40 , in pepper immunity. Ralstonia solanacearum inoculation (RSI) in pepper plants resulted in downregulation of CaWRKY40b transcript, and green fluorescent protein (GFP)-tagged CaWRKY40b was localized to the nuclei when transiently overexpressed in the leaves of Nicotiana benthamiana ...
May 8, 2018: International Journal of Molecular Sciences
Mei Xiang Chen, Chen Jie Hou, Ting Chen, Yan Ping Li, Yan Ling Zeng
OBJECTIVES: To investigate the content of pepsin in salivary, and to assess the laryngophargeal lesions based on the reflux founding score (RFS) scale in asymptomatic volunteers, in order to provide a reference for the diagnosis of laryngopharyngeal reflux. METHODS: A total of 91 asymptomatic subjects were recruited in this study. Participants provided a fasting saliva specimen for pepsin measurement using enzyme-linked immunoadsorbent assay, completed the reflux symptom index (RSI) assessment and underwent laryngostroboscopic examination using a rigid endoscope...
March 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Xue Yan Li, Wen Xu, Li Yu Cheng
OBJECTIVES: To analyze the clinical characteristics of paroxysmal laryngospasm in adult. METHODS: A retrospective analysis was performed on 149 patients with paroxysmal laryngospasm in adult. All patients underwent the strobolaryngoscopy, completed the reflux symptom index (RSI) or the reflux finding score (RFS). Partial patients underwent an ambulatory 24-hour pH measurement. RESULTS: Laryngospasm was diagnosed in 76 females and 73 males...
March 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Kamran A Ahmed, Jacob G Scott, John A Arrington, Arash O Naghavi, G Daniel Grass, Bradford A Perez, Jimmy J Caudell, Anders E Berglund, Eric A Welsh, Steven A Eschrich, Thomas J Dilling, Javier F Torres-Roca
INTRODUCTION: We assessed the radiosensitivity of lung metastases based on primary histology using a validated gene signature and model lung metastases for the genomically adjusted radiation dose (GARD). METHODS: Tissue samples were identified from our prospective observational protocol. The radiosensitivity index (RSI) 10 gene assay was run on samples and calculated alongside GARD using the previously published algorithms. A cohort of 105 patients with 137 lung metastases treated with SBRT at our institution was used for clinical correlation...
May 4, 2018: Journal of Thoracic Oncology
Fábio Azevedo Caparroz, Milena de Almeida Torres Campanholo, Caroline Gomez Regina, Sung Woo Park, Leonardo Haddad, Luís Carlos Gregório, Fernanda Louise Martinho Haddad
INTRODUCTION: Obstructive sleep apnea syndrome and laryngopharyngeal reflux are diseases with a high prevalence in the overall population; however, it remains unclear whether they are diseases with the same risk factors present in the same populations or if there is any association between them. OBJECTIVES: To evaluate and determine the prevalence of laryngopharyngeal reflux in patients with moderate and severe obstructive apnea syndrome and also to determine its predictive factors...
April 14, 2018: Brazilian Journal of Otorhinolaryngology
Ketan Sakharam Kulkarni, Nandini Dave, Shriyam Saran, Madhu Garasia, Sandesh Parelkar
During positive pressure ventilation, gastric inflation and subsequent pulmonary aspiration can occur. Rapid sequence induction (RSI) technique is an age-old formula to prevent this. We adopted a novel approach of RSI for patients with high risk of aspiration and evaluated it further in patients undergoing laparoscopic surgeries. We believe that, in patients with risk of gastric insufflation and pulmonary aspiration, transnasal humidified rapid-insufflation ventilatory exchange can be useful in facilitating pre- and apnoeic oxygenation till tracheal isolation is achieved...
April 2018: Indian Journal of Anaesthesia
Kate E Webster, Christopher V Nagelli, Timothy E Hewett, Julian A Feller
BACKGROUND: Anterior cruciate ligament (ACL) injury has a significant psychological effect, and a negative psychological state is a commonly cited reason for a reduction or cessation of sports participation after ACL reconstruction (ACLR) surgery. PURPOSE: To identify factors that contribute to an athlete's psychological readiness to return to sport (RTS) after ACLR. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: A cohort of 635 athletes (389 male, 246 female) who underwent ACLR and had been cleared to RTS completed the Anterior Cruciate Ligament-Return to Sport After Injury (ACL-RSI) scale at an average 12 months (range, 11-24 months) after surgery...
May 1, 2018: American Journal of Sports Medicine
M Bianchetti, S Peralta, R Nicita, S E Aragona, G Ciprandi
Gastroesophageal reflux disease (GERD) is a very common disorder. As there is no gold standard diagnostic tool, patient-based strategy is adopted in clinical practice. In this regard, there are questionnaires able to easily and rapidly assess symptom severity directly by the patient. The GERD Impact Scale (GIS) and the Reflux Symptom Index (RSI) have been validated as diagnostic tools in routine clinical care. The present study aimed to correlate RIS values with GIS scores in a large cohort of GERD patients visited at gastroenterological clinics...
April 26, 2018: Journal of Biological Regulators and Homeostatic Agents
M Bianchetti, S Peralta, R Nicita, S E Aragona, G Ciprandi
Gastroesophageal reflux disease (GERD) is a very common disease, as about a quarter of the Western population has GERD symptoms at least weekly and GERD is the most frequent reason for outpatient gastroenterology consultation. GERD treatment is based on proton pump inhibitor (PPI) use, but PPI may be ineffective in some patients and potentially unsafe if administered for very long time. A new medical compound (Marial®) has been introduced on the Italian market. This product contains magnesium alginate and a phytopolymer: it may be able to repair ulcer/erosion, protect mucosal tissue, and contrast acid contents...
April 26, 2018: Journal of Biological Regulators and Homeostatic Agents
M Bianchetti, S Peralta, R Nicita, S E Aragona, G Ciprandi
Gastroesophageal reflux disease (GERD) is defined as a “disease that develops when the reflux of stomach contents induces troublesome symptoms and/or complications”. From a therapeutic point of view, many options have been proposed, including proton pump inhibitors (PPI), antihistamines (H2- receptor antagonists), antacid chemical compounds, antireflux barrier (using alginates), prokinetics, inhibitors of gastric sphincters, protection of mucosal tissue, neuromodulators, nociceptor antagonists, lifestyle modification, and surgery...
April 26, 2018: Journal of Biological Regulators and Homeostatic Agents
Federica Rosso, Davide E Bonasia, Umberto Cottino, Simone Cambursano, Federico Dettoni, Roberto Rossi
Purpose  To analyze the prognostic factors influencing subjective and objective outcomes and return to play (RTP) after anterior cruciate ligament reconstruction (ACL-R). Methods  Primary ACL-Rs using a transtibial technique performed between 2008 and 2012 were included. Data regarding patients, surgery, sports, and rehabilitation, including an on-field rehabilitation (OFR) and duration of the rehabilitation program, were collected. The International Knee Documentation Committee (IKDC) subjective and objective evaluation forms, and the Knee Injury and Osteoarthritis Outcome Score and Lysholm questionnaires were used for the assessment of subjective and objective outcomes...
March 2018: Joints
Adam S Lepley, Brian Pietrosimone, Marc L Cormier
CONTEXT:   Interactions among muscle strength, pain, and self-reported outcomes in patients with anterior cruciate ligament reconstruction (ACLR) are not well understood. Clarifying these interactions is of clinical importance because improving physical and psychological function is thought to optimize outcomes after ACLR. OBJECTIVE:   To examine the relationships among neuromuscular quadriceps function, pain, self-reported knee function, readiness to return to activity, and emotional response to injury both before and after ACLR...
April 2018: Journal of Athletic Training
Kate E Webster, Julian A Feller
Background: The Anterior Cruciate Ligament Return to Sport After Injury (ACL-RSI) scale was developed to measure an athlete's psychological readiness to return to sport after anterior cruciate ligament (ACL) injury and reconstruction surgery. The scale is being used with increasing frequency in both research and clinical settings. Purpose: To generate and validate a short version of the ACL-RSI scale. Study Design: Cohort study (diagnosis); Level of evidence, 2...
April 2018: Orthopaedic Journal of Sports Medicine
Mahmoud Mosli, Bashaer Alkhathlan, Abdulmalik Abumohssin, Mazin Merdad, Ameen Alherabi, Osama Marglani, Hani Jawa, Talal Alkhatib, Hani Z Marzouki
Background/Aims: Gastroesophageal reflux disease (GERD) is a common condition that can lead to significant morbidity. Laryngopharyngeal reflux (LPR) is a distinct clinical entity that can occur simultaneously with GERD, necessitating additional treatment measures. The degree of overlap and clinical predictors of LPR among patients with GERD remains unknown. We aim to measure the prevalence of LPR in patients with GERD and identify clinical predictors. Patients and Methods: We performed a cross-sectional study involving patients with confirmed GERD according to the GERD questionnaire (GerdQ) using the reflux symptom index (RSI)...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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