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https://www.readbyqxmd.com/read/29165935/peripapillary-perfused-capillary-density-in-exfoliation-syndrome-and-exfoliation-glaucoma-versus-poag-and-healthy-controls-an-octa-study
#1
Yanin Suwan, Lawrence S Geyman, Masoud Aghsaei Fard, Apichat Tantraworasin, Toco Y Chui, Richard B Rosen, Robert Ritch
PURPOSE: To compare the peripapillary perfused capillary density (PCD) among eyes with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), primary open-angle glaucoma (POAG), and controls. DESIGN: Observational, cross-sectional study. METHODS: Optical coherence tomography angiography (OCTA) images (4.5×4.5 mm) of the optic nerve head were obtained using a commercial spectral domain OCTA system (AngioVue Avanti RTVue-XR, OptoVue, Fremont, CA)...
November 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29165106/the-impact-of-different-lenses-on-visual-and-musculoskeletal-complaints-in-vdu-workers-with-work-related-neck-complaints-a-randomized-controlled-trial
#2
Barbara Cagnie, Kayleigh De Meulemeester, Lieselotte Saeys, Lieven Danneels, Liesbet Vandenbulcke, Birgit Castelein
OBJECTIVES: The impact of wearing lenses on visual and musculoskeletal complaints in VDU workers is currently unknown. The goal of this study was 1) to evaluate the impact of wearing VDU lenses on visual fatigue and self-reported neck pain and disability, compared to progressive lenses, and 2) to measure the effect of both lenses on head inclination and pressure pain thresholds during the performance of a VDU task. METHODS: Thirty-five eligible subjects were randomly assigned to wear progressive VDU lenses (VDU group) (n = 18) or progressive lenses (P group) (n = 17)...
March 16, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164845/current-therapeutic-options-and-treatments-in-development-for-the-management-of-primary-open-angle-glaucoma
#3
Jeffrey M Liebmann, Jeannie K Lee
Primary open angle glaucoma (POAG) is the most common type of glaucoma, and is responsible for approximately 90% of glaucoma cases in North America. POAG is characterized by an asymptomatic onset, where patients do not present with symptoms until significant visual loss occurs in late stages of the disease. Importantly, while glaucoma is associated with several risk factors that contribute to damage and disease progression, intraocular pressure (IOP) is the only proven modifiable risk factor at this time. Treatments for POAG include use of pharmacologic and surgical interventions...
September 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29164425/outflow-graft-anastomosis-site-design-could-be-correlated-to-aortic-valve-regurgitation-under-left-ventricular-assist-device-support
#4
Kei Iizuka, Tomohiro Nishinaka, Yuki Ichihara, Takuma Miyamoto, Kenji Yamazaki
Aortic valve regurgitation (AR) is a critical complication during circulatory support with a left ventricular assist device (LVAD). The time-course of AR and related factors, including outflow graft anastomosis site design, were investigated. Twenty-three patients who had continuous-flow LVAD implantation and were supported for more than 6 months were investigated. AR grade (none, 0; trivial, 0.5; mild, 1; mild-moderate, 1.5; moderate, 2; moderate-severe, 2.5; severe, 3) and aortic valve opening were evaluated with echocardiography...
November 21, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29164179/schroth-physiotherapeutic-scoliosis-specific-exercises-for-adolescent-idiopathic-scoliosis-how-many-patients-require-treatment-to-prevent-one-deterioration-results-from-a-randomized-controlled-trial-sosort-2017-award-winner
#5
Sanja Schreiber, Eric C Parent, Doug L Hill, Douglas M Hedden, Marc J Moreau, Sarah C Southon
Background: Recent randomized controlled trials (RCTs) support using physiotherapeutic scoliosis-specific exercises (PSSE) for adolescents with idiopathic scoliosis (AIS). All RCTs reported statistically significant results favouring PSSE but none reported on clinical significance. The number needed to treat (NNT) helps determine if RCT results are clinically meaningful. The NNT is the number of patients that need to be treated to prevent one bad outcome in a given period. A low NNT suggests that a therapy has positive outcomes in most patients offered the therapy...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/29161717/subconjunctival-prgf-fibrin-membrane-as-an-adjuvant-to-nonpenetrating-deep-sclerectomy-a-2-year-pilot-study
#6
Iñaki Rodríguez-Agirretxe, Vanesa Freire, Francisco Muruzabal, Gorka Orive, Eduardo Anitua, Elio Díez-Feijóo, Arantxa Acera
PURPOSE: To evaluate the potential role of the autologous PRGF (plasma rich in growth factors) fibrin membrane in tissue regeneration after glaucoma filtering surgery. MATERIALS AND METHODS: Ten patients with medically uncontrolled primary open-angle glaucoma underwent nonpenetrating deep sclerectomy and were treated with PRGF fibrin membrane as adjuvant. Intraocular pressure reduction was the primary outcome. This variable was measured preoperatively and also at each follow-up visit...
November 22, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29160348/distribution-of-stress-on-tmj-disc-induced-by-use-of-chincup-therapy-assessment-by-the-finite-element-method
#7
Flávio Siqueira Calçada, Antônio Sérgio Guimarães, Marcelo Lucchesi Teixeira, Flávio Atsushi Takamatsu
OBJECTIVE: To assess the distribution of stress produced on TMJ disc by chincup therapy, by means of the finite element method. METHODS: a simplified three-dimensional TMJ disc model was developed by using Rhinoceros 3D software, and exported to ANSYS software. A 4.9N load was applied on the inferior surface of the model at inclinations of 30, 40, and 50 degrees to the mandibular plane (GoMe). ANSYS was used to analyze stress distribution on the TMJ disc for the different angulations, by means of finite element method...
September 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29156062/surgical-technique-for-pulled-in-two-syndrome-three-cases-with-chronic-progressive-external-ophthalmoplegia
#8
Alexander Matthew Jones, Julia Starte, Hamish Dunn, Kate Ahmad, Kimberley Tan
The authors describe three examples of "pulled in two syndrome" (PITS) from a series of 13 patients undergoing strabismus surgery with underlying chronic progressive external ophthalmoplegia (CPEO) and illustrate techniques for recovery of the "pulled in two" extraocular muscle should the complication arise. In all cases, a rectus muscle snapped under minimal tension while held on a strabismus hook during strabismus surgery. Two patients suffered from CPEO as a result of genetic mitochondrial disease, whereas one resulted from presumed mitochondrial toxicity induced by HAART...
November 17, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29155474/visual-biofeedback-using-trans-perineal-ultrasound-during-the-second-stage-of-labor
#9
Yinon Gilboa, Tahl I Frenkel, Yael Schlesinger, Sofie Rousseau, Daniel Hamiel, Reuven Achiron, Sharon Perlman
OBJECTIVES: to assess the obstetrical and psychological effect of visual biofeedback using trans-perineal ultrasound (TPU) during the second stage of labor. METHODS: Visual biofeedback using TPU was performed prospectively during the second stage of labor in twenty-six low risk nulliparous women. Pushing efficacy was assessed by the angle of progression at rest and during pushing efforts before and after observing the ultrasound screen. Obstetrical outcomes included level of perineal tearing, mode of delivery and length of the second stage...
November 20, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29154037/sex-and-age-specific-modulation-of-brain-gaba-levels-in-a-mouse-model-of-alzheimer-s-disease
#10
Upasana Roy, Lara Stute, Corinna Höfling, Maike Hartlage-Rübsamen, Jörg Matysik, Steffen Roβner, A Alia
Age and sex are risk factors of Alzheimer's disease (AD). Among the neurotransmitter systems, gamma-aminobutyric acid (GABA) has been implicated in AD pathogenesis but the relevance of sex-specific GABAergic dysfunction during AD progression remains unknown. In the present study, we utilized state-of-the-art high-resolution magic angle spinning nuclear magnetic resonance to systematically monitor the brain region-, age-, and sex-specific modulation of GABA levels in wild-type and Tg2576 mice with amyloid pathology...
October 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29150301/is-subchondral-bone-cyst-formation-in-non-load-bearing-region-of-osteoarthritic-knee-a-vascular-problem
#11
Pok Man Boris Chan, Chunyi Wen, Wai Ching Yang, Chunhoi Yan, KwongYuen Chiu
Subchondral bone cyst is common in the progressive knee osteoarthritis yet its underlying mechanism remains unclear. In addition to the existing theories such as synovial fluid influx and mechanical contusion, we identified the potential link between vascular pathology and osteoarthritic bone pathologies including cystic lesion formation, particularly in the non-load-bearing region. This new hypothesis for SBC formation in non-load-bearing region for knee, which cannot be explained by the existing theories, will provide us a new angle to understand the pathomechanism and pathophysiology of subchondral bone disturbance in osteoarthritis in addition to the classical biomechanical overloading theories...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29144509/circular-rna-expression-is-suppressed-by-androgen-receptor-ar-regulated-adenosine-deaminase-that-acts-on-rna-adar1-in-human-hepatocellular-carcinoma
#12
Liang Shi, Peijian Yan, Yuelong Liang, Yin Sun, Jiliang Shen, Senjun Zhou, Hui Lin, Xiao Liang, Xiujun Cai
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy as a result of complex genetic and epigenetic alterations. HCC is characterized by a clear gender disparity for which there is lack of a clear mechanistic understanding. Androgen receptor (AR) is thought to be critical for such bias. Meanwhile, the potential function of circular RNA (circRNA), regulated by RNA editing enzyme, remained largely unknown in malignancy till now. By utilizing circRNA microarray survey coupled with in vitro analysis, we analyzed the influence of AR on circRNA expression in HCC...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29141852/collagen-alignment-as-a-predictor-of-recurrence-after-ductal-carcinoma-in-situ
#13
Matthew W Conklin, Ronald E Gangnon, Brian L Sprague, Lisa van Germert, John M Hampton, Kevin W Eliceiri, Jeremy S Bredfeldt, Yuming Liu, Nuntida Surachaicharn, Polly A Newcomb, Andreas Friedl, Patricia Keely, Amy Trentham-Dietz
BACKGROUND: Collagen fibers surrounding breast ducts may influence breast cancer progression. Syndecan-1 interacts with constituents in the extracellular matrix, including collagen fibers, and may contribute to cancer cell migration. Thus, the orientation of collagen fibers surrounding ductal carcinoma in situ (DCIS) lesions and stromal syndecan-1 expression may predict recurrence. METHODS: We evaluated collagen fiber alignment and syndecan-1 expression in 227 women diagnosed with DCIS in 1995-2006 followed through 2014 (median 14...
November 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29137725/a-gait-retraining-system-using-augmented-reality-to-modify-footprint-parameters-effects-on-lower-limb-sagittal-plane-kinematics
#14
Sami Bennour, Baptiste Ulrich, Thomas Legrand, Brigitte M Jolles, Julien Favre
Improving lower-limb flexion/extension angles during walking is important for the treatment of numerous pathologies. Currently, these gait retraining procedures are mostly qualitative, often based on visual assessment and oral instructions. This study aimed to propose an alternative method combining motion capture and display of target footprints on the floor. The second objectives were to determine the error in footprint modifications and the effects of footprint modifications on lower-limb flexion/extension angles...
November 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29135482/long-term-darapladib-use-does-not-affect-coronary-plaque-composition-assessed-using-multimodality-intravascular-imaging-modalities-a-randomized-controlled-study
#15
Woong Gil Choi, Megha Prasad, Ryan Lennon, Rajiv Gulati, Abhiram Prasad, Lilach O Lerman, Amir Lerman
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) may play a role in plaque progression and vulnerability. We aimed to define plaque characteristics on multimodality intravascular imaging in patients with coronary endothelial dysfunction in response to long-term inhibition of Lp-PLA2 by darapladib. PATIENTS AND METHODS: This is a double-blinded, randomized study screening 70 patients, and enrolling 54 patients with suspected ischemia, without obstructive disease on angiography and with coronary endothelial dysfunction by invasive assessment...
November 10, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29133915/impact-of-spatial-characteristics-in-the-left-stenotic-coronary-artery-on-the-hemodynamics-and-visualization-of-3d-replica-models
#16
Yang Yang, Xin Liu, Yufa Xia, Xin Liu, Wanqing Wu, Huahua Xiong, Heye Zhang, Lin Xu, Kelvin K L Wong, Hanbin Ouyang, Wenhua Huang
Cardiovascular disease has been the major cause of death worldwide. Although the initiation and progression mechanism of the atherosclerosis are similar, the stenotic characteristics and the corresponding medical decisions are different between individuals. In the present study, we performed anatomic and hemodynamic analysis on 8 left coronary arterial trees with 10 identified stenoses. A novel boundary condition method had been implemented for fast computational fluid dynamics simulations and patient-specific three-dimensional printed models had been built for visualizations...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133000/effectiveness-of-a-decision-making-protocol-for-the-surgical-treatment-of-lumbar-stenosis-with-grade-1-degenerative-spondylolisthesis
#17
Victor E Staartjes, Marc L Schröder
BACKGROUND: The addition of fusion to decompression for stenosis with Grade I degenerative spondylolisthesis is a controversial topic, and the question remains if fusion provides any real benefit to the patient that warrants the increased healthcare utilization and perioperative morbidity. In addition, there is no consensus on indications for the use of fusion over decompression alone. METHODS: Patients received fusion or decompression according to a decision-making protocol based on their pattern of complaints, the location of the compression, as well as facet angles and effusion as proven predictors of postoperative instability...
November 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29131911/time-and-factors-affecting-the-direction-of-re-drift-in-essential-infantile-esotropia
#18
Kun-Hoo Na, Yoonae A Cho, Seung-Hyun Kim
PURPOSE: To investigate the development pattern and related factors of postoperative re-drift in infantile esotropia. METHODS: A total of 112 patients with infantile esotropia who underwent surgery before 3 years of age were included. Surgical outcomes were divided into (1) consecutive exotropia: more than 8 prism diopters (PD) of exodeviation; (2) recurrent esotropia: more than 8 PD of esodeviation; and (3) monofixation syndrome: maintenance of deviations within 8 PD...
November 11, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29131903/slow-reading-in-glaucoma-is-it-due-to-the-shrinking-visual-span-in-central-vision
#19
MiYoung Kwon, Rong Liu, Bhavika N Patel, Christopher Girkin
Purpose: Glaucoma is a leading cause of blindness worldwide, characterized by progressive loss of retinal ganglion cells. Patients with bilateral glaucoma read slower than normal cohorts. Here we examined the factors that may underlie slow reading in glaucoma and determined the best predictor of reading speed in glaucoma. Methods: A total of 38 subjects participated in this study: 17 patients with primary open-angle glaucoma (mean age = 64.71 years) and 21 age-similar normal controls (58...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29129617/computed-tomographic-evaluation-of-bone-stock-in-patients-with-crowe-type-iii-developmental-dysplasia-of-the-hip-implications-for-guiding-acetabular-component-placement-using-the-high-hip-center-technique
#20
Bo Liu, Yu-Hang Gao, Lu Ding, Shu-Qiang Li, Jian-Guo Liu, Xin Qi
BACKGROUND: We evaluated acetabular cup coverage (CC) and rim contact (RC) to evaluate the bone stock above the acetabulum for guiding acetabular component placement using the high hip center technique in patients with Crowe type III developmental dysplasia of the hip. METHODS: Using hip computed tomography and image processing software, pelvises were reconstructed digitally in 20 hips with Crowe type III developmental dysplasia of the hip. Mimicked cup was placed with anteversion angles of 0° (group I), 5° (group II), and 10° (group III) respectively...
October 24, 2017: Journal of Arthroplasty
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