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https://www.readbyqxmd.com/read/27910507/the-progress-in-development-of-edge-tangential-thomson-scattering-system-on-hl-2a-tokamak
#1
C H Liu, Y Huang, Y Q Wang, Z Feng, Z P Hou, B Z Fu
The edge tangential Thomson scattering system (ETTSS) was developed for the first time on a HL-2A tokamak. A Nd:YAG laser with a 1064 nm wavelength, 4 J energy, and 30 Hz repetition rate is employed on the ETTSS. The laser beam injects the plasma in the tangential direction on the mid-plane of the machine, and the angles between the laser injection direction and the scattered light collection direction are in the range from 157.5° to 162.8°. The scattered light collection optics with 0.21-0.47 magnification is utilized to collect the scattered light of measurement range from R = 1900 mm to 2100 mm (the normalized radius is from r/a = 0...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27906290/polarization-variable-emitter-for-terahertz-time-domain-spectroscopy
#2
Dmitry S Bulgarevich, Makoto Watanabe, Mitsuharu Shiwa, Gudrun Niehues, Hideaki Kitahara, Masahiko Tani
We report on the progress in the development of linear polarization-variable multi-electrode emitters for terahertz time-domain spectroscopy. The results on its microfabrication, the finite element method modeling of appropriate bias distribution between electrodes, the finite-difference time-domain simulated spectral output, and actual experimental testing are presented. The rotation of the emitted terahertz field with linear polarization on an angle multiple of 45° can be achieved by synchronized bias and single polarizer rotations...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27904699/generation-of-induced-pluripotent-stem-cells-with-high-efficiency-from-human-embryonic-renal-cortical-cells
#3
Ling Yao, Ruifang Chen, Pu Wang, Qi Zhang, Hailiang Tang, Huaping Sun
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) emerges as a prospective therapeutic angle in regenerative medicine and a tool for drug screening. Although increasing numbers of iPSCs from different sources have been generated, there has been limited progress in yield of iPSC. Here, we show that four Yamanaka factors Oct4, Sox2, Klf4 and c-Myc can convert human embryonic renal cortical cells (hERCCs) to pluripotent stem cells with a roughly 40-fold higher reprogramming efficiency compared with that of adult human dermal fibroblasts...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27903713/-trained-immunity-consequences-for-lymphoid-malignancies
#4
REVIEW
Wendy B C Stevens, Mihai G Netea, Arnon P Kater, Walter J F M van der Velden
In hematological malignancies complex interactions exist between the immune system, microorganisms and malignant cells. On one hand, microorganisms can induce cancer, as illustrated by specific infection-induced lymphoproliferative diseases such as Helicobacter pylori-associated gastric mucosa-associated lymphoid tissue lymphoma. On the other hand, malignant cells create an immunosuppressive environment for their own benefit, but this also results in an increased risk of infections. Disrupted innate immunity contributes to the neoplastic transformation of blood cells by several mechanisms, including the uncontrolled clearance of microbial and autoantigens resulting in chronic immune stimulation and proliferation, chronic inflammation, and defective immune surveillance and anti-cancer immunity...
December 2016: Haematologica
https://www.readbyqxmd.com/read/27902635/correlation-between-transverse-plan-kinematics-and-foot-progression-angle-in-children-with-spastic-diplegia
#5
Ana Presedo, Anne-Laure Simon, Cindy Mallet, Brice Ilharreborde, Keyvan Mazda, Georges-François Pennecot
In diplegic patients, the orientation of foot progression depends on multiple factors. We investigated the relationship between foot progression alignment, hip and pelvic rotations during gait, femoral anteversion, and tibial torsion. Kinematic and clinical parameters were evaluated for 114 children who walked independently and had not undergone previous surgery. Causes of intoeing presented combined in 72% of cases. Internal foot progression correlated with internal hip rotation and showed an inverse correlation with tibial torsion...
November 29, 2016: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/27898606/facial-nerve-meningioma-a-cause-of-pediatric-facial-weakness
#6
Nicholas L Deep, Sharon H Gnagi, David F Carpentieri, P David Adelson, Peter A Weisskopf
OBJECTIVE: To present an unusual case of a temporal bone meningioma with intrafascicular spread throughout the temporal facial nerve from cerebellopontine angle (CPA) to stylomastoid foramen. PATIENT: Four-year-old female with progressive facial weakness and normal hearing. MAIN OUTCOME MEASURE: Clinical, radiological, and histopathological findings of temporal bone meningiomas. RESULTS: A patient presented with progressive facial weakness and normal hearing...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27898467/an-update-on-therapeutic-modalities-for-the-prevention-of-angle-closure-glaucoma
#7
Behzad Amoozgar, Sasan Moghimi, Ying Han, Shan C Lin
PURPOSE OF REVIEW: Angle closure glaucoma is a prominent burden for the worldwide health system. Because this disorder is commonly asymptomatic, and can lead to irreversible blindness, the proper screening and early management of this disease can be critical. The definitions of angle closure and consequently its treatment guidelines have been dynamically modified and updated in the past decades. Surgical and laser techniques have been adapted to address the different mechanisms involved in the manifestation of the disease and properly prevent its progression in different stages...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27896214/a-case-of-severe-mandibular-retrognathism-with-bilateral-condylar-deformities-treated-with-le-fort-i-osteotomy-and-two-advancement-genioplasty-procedures
#8
Masahiro Nakamura, Takeshi Yanagita, Tatsushi Matsumura, Takashi Yamashiro, Seiji Iida, Hiroshi Kamioka
We report a case involving a young female patient with severe mandibular retrognathism accompanied by mandibular condylar deformity that was effectively treated with Le Fort I osteotomy and two genioplasty procedures. At 9 years and 9 months of age, she was diagnosed with Angle Class III malocclusion, a skeletal Class II jaw relationship, an anterior crossbite, congenital absence of some teeth, and a left-sided cleft lip and palate. Although the anterior crossbite and narrow maxillary arch were corrected by interceptive orthodontic treatment, severe mandibular hypogrowth resulted in unexpectedly severe mandibular retrognathism after growth completion...
November 2016: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/27888089/quantitative-measurements-of-the-skull-base-and-craniovertebral-junction-in-congenital-occipitalization-of-the-atlas-a-ct-based-anatomical-study
#9
Rui Zong, Yiheng Yin, Guangyu Qiao, Yazhou Jin, Xinguang Yu
BACKGROUND: To study the craniovertebral junction (CVJ) and determine the anatomical characteristics of occipitalization of the atlas (OC) by computed tomography imaging. METHODS: We retrospectively reviewed 80 cases of patients with OC who underwent cervical CT scanning between March 2012 and March 2014. Forty healthy subjects were recruited as a control cohort. Fusion pattern and associated osseous anomalies were recorded. Fifteen linear quantitative parameters were measured to study the outlet of the foramen magnum, angular dimension of the skull base, posterior cranial fossa, and height of the odontoid process...
November 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27887743/quantification-of-diabetic-macular-ischemia-using-optical-coherence-tomography-angiography-and-its-relationship-with-visual%C3%A2-acuity
#10
Wasim A Samara, Abtin Shahlaee, Murtaza K Adam, M Ali Khan, Allen Chiang, Joseph I Maguire, Jason Hsu, Allen C Ho
PURPOSE: To quantify foveal avascular zone (FAZ) area and macular vascular density objectively using optical coherence tomography angiography (OCTA) and to examine correlations with visual acuity in eyes with diabetic retinopathy (DR) in the absence of diabetic macular edema. DESIGN: Retrospective observational case series. PARTICIPANTS: Eighty-four eyes from 55 patients with DR and 34 control eyes from 27 age-matched healthy participants...
November 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27882360/static-and-dynamic-predictors-of-foot-progression-angle-in-individuals-with-and-without-diabetes-mellitus-and-peripheral-neuropathy
#11
Ericka N Merriwether, Mary K Hastings, Michael J Mueller, Kathryn L Bohnert, Michael J Strube, Darrah R Snozek, David R Sinacore
INTRODUCTION: Foot progression angle (FPA) is a predictor of elevated regional plantar stresses and loads, which are indicators of dermal injury risk in individuals with diabetes mellitus and peripheral neuropathy (DMPN). FPA accounts for 15-45% of the variance in plantar stresses and loads in adults with DMPN. However, the biomechanical factors underlying an "out-toeing" gait pattern in this clinical population have not been examined. The primary purpose of this study was to identify static and dynamic predictors of foot progression angle magnitude in adults with and without DMPN...
2016: Annals of Gerontology and Geriatric Research
https://www.readbyqxmd.com/read/27872189/biophysical-evidence-for-intrinsic-disorder-in-the-c-terminal-tails-of-the-egfr-and-her3-receptor-tyrosine-kinases
#12
Theodore R Keppel, Kwabena Sarpong, Elisa M Murray, John Monsey, Jian Zhu, Ron Bose
The EGFR/ErbB family of receptor tyrosine kinases includes oncogenes important in the progression of breast and other cancers and they are targets for many drug development strategies. Each member of the ErbB family possesses a unique, structurally uncharacterized C-terminal tail that plays an important role in autophosphorylation and signal propagation. To determine if these C-terminal tails are intrinsically disordered regions, we conducted a battery of biophysical experiments on the EGFR and HER3 tails. Using hydrogen/deuterium exchange mass spectrometry, we measured the conformational dynamics of intracellular half constructs and compared the tails to the ordered kinase domains...
November 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27871017/predicting-postoperative-gait-in-cerebral-palsy
#13
Omar A Galarraga C, Vincent Vigneron, Bernadette Dorizzi, Néjib Khouri, Eric Desailly
In this work, postoperative lower limb kinematics are predicted with respect to preoperative kinematics, physical examination and surgery data. Data of 115 children with cerebral palsy that have undergone single-event multilevel surgery were considered. Preoperative data dimension was reduced utilizing principal component analysis. Then, multiple linear regressions with 80% confidence intervals were performed between postoperative kinematics and bilateral preoperative kinematics, 36 physical examination variables and combinations of 9 different surgical procedures...
November 9, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27866913/minimally-invasive-plate-osteosynthesis-with-philos-plate-for-proximal-humerus-fractures
#14
Uğur Gönç, Mesut Atabek, Kürşat Teker, Altuğ Tanrıöver
OBJECTIVES: The aim of the present study was to evaluate results, including clinical and radiological outcomes and number of complications, following minimally invasive plate osteosynthesis (MIPO) of proximal humerus fractures, using the PHILOS® proximal humerus internal locking system (Synthes Holding AG, Solothurn, Switzerland). METHODS: Retrospectively evaluated were 31 patients treated with MIPO (12 male, 19 female; average age: 58.4 years). Four patients had 2-part fractures, 14 patients had 3-part fractures, and 13 patients had 4-part fractures, according to Neer classification...
November 18, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27863678/formulation-and-characterization-of-a-liquid-crystalline-hexagonal-mesophase-region-of-phosphatidylcholine-sorbitan-monooleate-and-tocopherol-acetate-for-sustained-delivery-of-leuprolide-acetate
#15
Yahira M Báez-Santos, Andrew Otte, Ellina A Mun, Bong-Kwan Soh, Chang-Geun Song, Young-Nam Lee, Kinam Park
Although liquid crystal (LC) systems have been studied before, their utility in drug delivery applications has not been explored in depth. This study examined the development of a 1-month sustained release formulation of leuprolide acetate using an in situ-forming LC matrix. The phase progression upon water absorption was tested through construction of ternary phase diagrams of phosphatidylcholine, sorbitan monooleate, and tocopherol acetate (TA) at increasing water content. Small angle X-ray scattering revealed the presence of lamellar and hexagonal mesophases...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27857874/minimizing-septectomy-for-endoscopic-transsphenoidal-approaches-to-the-sellar-and-suprasellar-regions-a-cadaveric-morphometric-study
#16
Hermes G Garcia, Marc Otten, Marc Pyfer, Saurabh J Singhal, Alfred Marc Iloreta, Varun R Kshettry, Christopher J Farrell, Gurston Nyquist, Marc Rosen, James J Evans
The purpose of this study was to evaluate the effect of posterior septectomy size on surgical exposure and surgical freedom during the endoscopic transsphenoidal approach to the sella and parasellar region. Dissections were performed on 10 embalmed cadaver heads. Dissections started with wide bilateral sphenoidotomies, lateralization of middle turbinates, and a 5-mm posterior septectomy. The posterior septectomy was increased in 5-mm increments to a maximum of 35 mm, followed by bilateral middle turbinectomies...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27857501/prospective-study-of-the-anterior-cruciate-ligament-reconstruction-associated-with-high-tibial-opening-wedge-osteotomy-in-knee-arthritis-associated-with-instability
#17
Raju Vaishya, Vipul Vijay, Gyanendra Kumar Jha, Amit Kumar Agarwal
INTRODUCTION: Chronic ACL insufficiency with associated varus malalignment due to knee osteoarthritis (OA) is challenging to treat surgically. A combined ACL reconstruction (ACLR) with medial open wedge high tibial osteotomy (HTO) without using any metallic implant for HTO is an effective technique. MATERIALS AND METHOD: All the patients attending the outpatient department ACL injury and with associated medial compartment OA (Kellegren's grade 2 and grade 3) were considered for inclusion in the study...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27854356/detection-of-multiple-stationary-humans-using-uwb-mimo-radar
#18
Fulai Liang, Fugui Qi, Qiang An, Hao Lv, Fuming Chen, Zhao Li, Jianqi Wang
Remarkable progress has been achieved in the detection of single stationary human. However, restricted by the mutual interference of multiple humans (e.g., strong sidelobes of the torsos and the shadow effect), detection and localization of the multiple stationary humans remains a huge challenge. In this paper, ultra-wideband (UWB) multiple-input and multiple-output (MIMO) radar is exploited to improve the detection performance of multiple stationary humans for its multiple sight angles and high-resolution two-dimensional imaging capacity...
November 16, 2016: Sensors
https://www.readbyqxmd.com/read/27853954/spectral-domain-optical-coherence-tomography-findings-in-idiopathic-lamellar-macular-hole
#19
Elena Zampedri, Federica Romanelli, Francesco Semeraro, Barbara Parolini, Rino Frisina
BACKGROUND: To evaluate demographic, functional, and morphological parameters of idiopathic lamellar macular hole (ILMH). METHODS: Observational longitudinal retrospective study. Optical coherence tomography examinations and corresponding clinical charts of a series of consecutive patients affected by ILMH, between January 2010 and March 2015, from the database of the Department of Ophthalmology of Trento Hospital, Italy, have been collected and examined. Demographic and functional parameters were: age (year), gender (male/female), eye (right/left), lens status, best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution (LogMAR)...
November 16, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27853536/orientation-of-tyrosine-side-chain-in-neurotoxic-a%C3%AE-differs-in-two-different-secondary-structures-of-the-peptide
#20
Swagata Das, Supriya Das, Anupam Roy, Uttam Pal, Nakul C Maiti
Amyloid β (Aβ) peptide is present as a major component in amyloid plaque that is one of the hallmarks of Alzheimer's disease. The peptide contains a single tyrosine residue and Aβ has a major implication in the pathology of the disease progression. Current investigation revealed that the tyrosine side chain attained two different critical stereo orientations in two dissimilar conformational states of the peptide. The extended α-helical structure of the peptide observed in an apolar solvent or methanol/water mixture became disordered in aqueous medium and the radius of gyration decreased...
October 2016: Royal Society Open Science
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