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https://www.readbyqxmd.com/read/28454482/effects-of-environmental-factors-and-metallic-electrodes-on-ac-electrical-conduction-through-dna-molecule
#1
S Abdalla, A Obaid, F M Al-Marzouki
BACKGROUND: Deoxyribonucleic acid (DNA) is one of the best candidate materials for various device applications such as in electrodes for rechargeable batteries, biosensors, molecular electronics, medical- and biomedical-applications etc. Hence, it is worthwhile to examine the mechanism of charge transport in the DNA molecule, however, still a question without a clear answer is DNA a molecular conducting material (wire), semiconductor, or insulator? The answer, after the published data, is still ambiguous without any confirmed and clear scientific answer...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454184/-register-of-difficult-surgical-situations
#2
Michael Korenkov, Henning Dralle, Ernst Klar, Stefan Saad, Norbert Senninger, Jens Standop, Albrecht Stier, Martin Strik, Alexis Ulrich, Rudolf Weiner
Every surgical problem that increases the likelihood of intraoperative and postoperative complications is considered to be a difficult surgical situation. Based on this definition, Korenkov et al. proposed to classify patients according to the following intraoperative difficulty levels (I to IV): (I) ideal situation (easy to operate, no problems), (II) fairly easy/manageable/simple (some minor difficulties may occur), (III) difficult/problematic (difficult to operate; some operative techniques are considerably more difficult than others), and (IV) very difficult (every operative step is difficult/challenging)...
April 28, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28454115/impact-of-marital-status-during-diagnosis-on-cancer-caused-specific-survival-in-acute-myeloid-leukemia-patients-a-case-control-and-population-based-study
#3
Zhuojun Zheng, Yuandong Zhu, Xiaodong Li, Wenwei Hu, Jingting Jiang
OBJECTIVE: This study investigated the impact of marital status on cancer-caused specific mortality among acute myeloid leukemia (AML) patients in the United States. METHODS: We used the Surveillance, Epidemiology and End Results program to identify 50,825 patients who had their clinical and follow-up information available and were diagnosed for AML between the years 1988 and 2015. The univariate and multivariable Cox regression models were used to analyze the patient data, and to minimize the group differences due to covariates between groups, a 1:1 propensity score matching was used in subsequent subgroup analysis...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454111/cost-and-cost-effectiveness-of-adjuvant-trastuzumab-in-the-real-world-setting-a-study-of-the-southeast-netherlands-breast-cancer-consortium
#4
Shanly C Seferina, Bram Lt Ramaekers, Maaike de Boer, M Wouter Dercksen, Franchette van den Berkmortel, Roel Jw van Kampen, Agnès J van de Wouw, Adri C Voogd, Vivianne Cg Tjan Heijnen, Manuela A Joore
BACKGROUND: We assessed the real world costs and cost-effectiveness of the addition of trastuzumab in HER2 positive early breast cancer compared to chemotherapy alone in the Dutch daily practice as opposed to the results based on trial data and based on a subset of patients that were treated according to the guidelines. PATIENTS AND METHODS: In a cohort study, we included all patients with stage I-III invasive breast cancer treated with curative intent in 5 Dutch hospitals between 2005 and 2007 (n=2684)...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454105/tea-consumption-and-the-risk-of-biliary-tract-cancer-a-systematic-review-and-dose-response-meta-analysis-of-observational-studies
#5
Jianping Xiong, Jianzhen Lin, Anqiang Wang, Yaqin Wang, Ying Zheng, Xinting Sang, Yiyao Xu, Xin Lu, Haitao Zhao
Recent studies have shown that tea consumption is associated with the reduced incidence of some types of cancer, possibly including biliary tract cancer. However, the epidemiological evidences for the association with risk of biliary tract cancer are contradictory. Thus, we performed meta-analysis of published observational studies to assess the association between tea consumption and risk of biliary tract cancer. Relevant studies were identified by searching PubMed, EMBASE, and ISI Web of Science published before October 2016...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454095/association-between-psca-gene-polymorphisms-and-the-risk-of-cancer-an-updated-meta-analysis-and-trial-sequential-analysis
#6
Zhiqiang Qin, Jingyuan Tang, Xiao Li, Yajie Yu, Chuanjie Zhang, Peng Han, Ran Li, Xuping Jiang, Chengdi Yang, Wei Wang, Min Tang, Wei Zhang
Previous studies have investigated the relationships between PSCA rs2294008 C>T and rs2976392 G>A polymorphisms and cancer susceptibility. However, the available findings remained inconsistent and even controversial. Thus, the aim of this meta-analysis was performed to clarify such associations. The online databases PubMed, EMBASE and Web of Science searched for relevant studies, covering all the papers published until September 1st, 2016. Data were pooled by odds ratios (ORs) with 95% confidence intervals (CIs) to evaluate the strength of such associations...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454010/how-economic-recessions-and-unemployment-affect-illegal-drug-use-a-systematic-realist-literature-review
#7
Gera E Nagelhout, Karin Hummel, Moniek C M de Goeij, Hein de Vries, Eileen Kaner, Paul Lemmens
BACKGROUND: Economic recessions may influence illegal drug use via different mechanisms, for example increased use due to more psychological distress or decreased use due to lower incomes and purchasing power. This paper reviews the literature on how economic recessions and unemployment affect the use of illegal drugs among adults. METHODS: We conducted a systematic realist literature review, which is an explanatory method that aims to understand underlying mechanisms that connect an event to an outcome in a specific context...
April 25, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28454007/groundwater-remediation-from-the-past-to-the-future-a-bibliometric-analysis
#8
Shu Zhang, Guozhu Mao, John Crittenden, Xi Liu, Huibin Du
Groundwater is an important component of terrestrial ecosystems and plays a role in geochemical cycling. Groundwater is also used for agricultural irrigation and for the domestic supply of drinking water in most nations. However, groundwater contamination has led to many research efforts on groundwater remediation technologies and strategies. This study evaluated a total of 5486 groundwater remediation-related publications from 1995 to 2015 using bibliometric technology and social network analysis, to provide a quantitative analysis and a global view on the current research trend and future research directions...
January 19, 2017: Water Research
https://www.readbyqxmd.com/read/28453994/synthesis-and-applications-of-benzohydroxamic-acid-based-histone-deacetylase-inhibitors
#9
REVIEW
Rob De Vreese, Matthias D'hooghe
This paper provides an overview of the synthesis and biological activity of the most representative benzohydroxamic acid-based histone deacetylase inhibitors published to date. Benzohydroxamic acids comprise an important class of HDAC inhibitors, and recently several of these structures have been evaluated in clinical trials for the treatment of a variety of cancers. In this overview, benzohydroxamic acids were divided in four different classes based on their reported selectivity towards zinc-dependent HDACs: a first and major class consists of HDAC6 selective inhibitors, a second class deals with pan-HDAC inhibitors, a third class comprises HDAC8 selective inhibitors and a fourth, minor class includes dual HDAC6/8 selective inhibitors...
April 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28453966/psychotherapy-for-depression-among-advanced-incurable-cancer-patients-a-systematic-review-and-meta-analysis
#10
REVIEW
Toru Okuyama, Tatsuo Akechi, Lisa Mackenzie, Toshi A Furukawa
BACKGROUND: There is a high prevalence of depressive disorder and depressive symptoms among advanced, incurable cancer patients. Patients commonly report a preference for non-pharmacological treatments such as psychotherapy over pharmacological treatments for depression. The objective of this review was to investigate the effectiveness of psychotherapy for the treatment of depression in people with advanced, incurable cancer via a meta-analysis of randomized controlled trials (RCTs). METHODS: We searched research databases and clinical trial registries for studies published prior to June 2015...
April 11, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28453904/genetics-and-other-factors-in-the-aetiology-of-female-pattern-hair-loss
#11
REVIEW
Silke Redler, Andrew G Messenger, Regina C Betz
Pattern hair loss is the most common form of hair loss in both women and men. Male pattern hair loss, also termed male androgenetic alopecia (M-AGA), is an androgen-dependent trait that is predominantly genetically determined. Androgen-mediated mechanisms are probably involved in FPHL in some women but the evidence is less strong than in M-AGA; and other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Genome-wide association studies (GWASs) have identified several genetic loci for M-AGA and have provided better insight into the underlying biology...
April 28, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28453892/the-psycho-social-impact-of-contralateral-risk-reducing-mastectomy-crrm-on-women-a-rapid-review
#12
REVIEW
Karen Collins, Melanie Gee, Anna Clack, Lynda Wyld
OBJECTIVES: For women who have been diagnosed with unilateral breast cancer there is an increasing trend for them to request removal of the contralateral healthy breast, so called contralateral risk reducing mastectomy (CRRM). The current literature is only just beginning to identify patient-reported reasons for undergoing CRRM and associated patient reported outcomes. It is also unclear whether women at moderate/high risk of developing a subsequent primary contralateral breast cancer report similar outcomes to those considered to be at low/average risk...
April 28, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28453839/virucidal-activity-of-world-health-organization-recommended-formulations-against-enveloped-viruses-including-zika-ebola-and-emerging-coronaviruses
#13
Anindya Siddharta, Stephanie Pfaender, Nathalie Jane Vielle, Ronald Dijkman, Martina Friesland, Britta Becker, Jaewon Yang, Michael Engelmann, Daniel Todt, Marc P Windisch, Florian H Brill, Joerg Steinmann, Jochen Steinmann, Stephan Becker, Marco P Alves, Thomas Pietschmann, Markus Eickmann, Volker Thiel, Eike Steinmann
The World Health Organization (WHO) published 2 alcohol-based formulations to be used in healthcare settings and for outbreak-associated infections, but inactivation efficacies of these products have not been determined against (re-)emerging viruses. In this study, we evaluated the virucidal activity of these WHO products in a comparative analysis. Zika virus (ZIKV), Ebola virus (EBOV), severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (MERS-CoV) as (re-)emerging viral pathogens and other enveloped viruses could be efficiently inactivated by both WHO formulations, implicating their use in healthcare systems and viral outbreak situations...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28453823/a-flowchart-for-building-evidence-based-care-bundles-in-intensive-care-based-on-a-systematic-review
#14
Marjon Borgert, Jan Binnekade, Frederique Paulus, Astrid Goossens, Dave Dongelmans
Purpose: The Institute for Healthcare Improvement is the founder of the care bundled approach and described the methods used on how to develop care bundles. However, other useful methods are published as well. In this systematic review, we identified what different methods were used to design care bundles in intensive care units. The results were used to build a comprehensive flowchart to guide through the care bundle design process. Data sources: Electronic databases were searched for eligible studies in PubMed, EMBASE and CINAHL from January 2001 to August 2014...
April 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28453792/triple-valve-surgery-through-a-less-invasive-approach-early-and-mid-term-results
#15
Petar Risteski, Nadejda Monsefi, Aleksandra Miskovic, Tanja Josic, Sherife Bala, Razan Salem, Andreas Zierer, Anton Moritz
OBJECTIVES: A partial upper sternotomy has become established as a less invasive approach mainly for single and double valve surgery. This report evaluates the clinical outcomes of triple valve surgery performed through a partial upper sternotomy. METHODS: We reviewed the medical records of 37 consecutive patients (28 men, 76%) who underwent triple valve surgery through a partial upper sternotomy between 2005 and 2015. The patients' mean age was 67 ± 17 years; 27 (73%) were in New York Heart Association Class III or IV...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453782/sempi-a-genome-based-secondary-metabolite-prediction-and-identification-web-server
#16
Paul F Zierep, Natàlia Padilla, Dimitar G Yonchev, Kiran K Telukunta, Dennis Klementz, Stefan Günther
The secondary metabolism of bacteria, fungi and plants yields a vast number of bioactive substances. The constantly increasing amount of published genomic data provides the opportunity for an efficient identification of gene clusters by genome mining. Conversely, for many natural products with resolved structures, the encoding gene clusters have not been identified yet. Even though genome mining tools have become significantly more efficient in the identification of biosynthetic gene clusters, structural elucidation of the actual secondary metabolite is still challenging, especially due to as yet unpredictable post-modifications...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28453713/does-charging-different-user-fees-for-primary-and-secondary-care-affect-first-contacts-with-primary-healthcare-a-systematic-review
#17
Thomas Hone, John Tayu Lee, Azeem Majeed, Lesong Conteh, Christopher Millett
Policy-makers are increasingly considering charging users different fees between primary and secondary care (differential user charges) to encourage utilisation of primary health care in health systems with limited gate keeping. A systematic review was conducted to evaluate the impact of introducing differential user charges on service utilisation. We reviewed studies published in MEDLINE, EMBASE, the Cochrane library, EconLIT, HMIC, and WHO library databases from January 1990 until June 2015. We extracted data from the studies meeting defined eligibility criteria and assessed study quality using an established checklist...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28453638/etg-ets-in-serum-by-uhplc-ms-ms-in-suspected-sexual-assault-cases
#18
Solfrid Hegstad, Arne Helland, Cecilie Hagemann, Olav Spigset
A method including semi-automated extraction of ethyl glucuronide (EtG) and ethyl sulfate (EtS) from serum followed by ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS-MS) has been developed and validated. Sample preparation prior to UHPLC-MS-MS analysis consisted of protein precipitation and filtration through a phospholipid removal plate. Chromatography was achieved using an HSS T3 column and gradient elution with formic acid in water in combination with methanol. The mass spectrometer was monitored in the negative mode with multiple reaction monitoring...
April 27, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28453616/prevalence-and-predictors-of-diastolic-dysfunction-according-to-different-classification-criteria-the-coronary-artery-risk-development-in-young-in-adults-study
#19
Laura J Rasmussen-Torvik, Laura A Colangelo, Joao A C Lima, David R Jacobs, Carlos J Rodriguez, Samuel S Gidding, Donald M Lloyd-Jones, Sanjiv J Shah
Heart failure with preserved ejection fraction is often preceded by diastolic dysfunction (DD). Of several published DD criteria, it is unclear which, if any, are applicable to data obtained in epidemiologic cohorts. We evaluated the prevalence of DD using previously published definitions in a population-based study, the Coronary Artery Risk Development in Young Adults (CARDIA) Study, using data gathered in 2010-2011. Echocardiography was performed on 3,474 individuals (mean age = 50.2 years) at the CARDIA year 25 examination...
April 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28453551/associations-between-cytokine-gene-polymorphisms-and-susceptibility-to-helicobacter-pylori-infection-and-helicobacter-pylori-related-gastric-cancer-peptic-ulcer-disease-a-meta-analysis
#20
Jingjing Ma, Dandan Wu, Xue Hu, Jiao Li, Mingwei Cao, Weiguo Dong
OBJECTIVES: The aim of this study is to clarify the associations between IL-1B31C/T, IL-1B-511C/T, IL-8-251T/A gene polymorphisms and the risk of Helicobacter pylori (H. pylori) infection together with H. pylori-related gastric cancer (GC), peptic ulcer disease (PUD). METHODS: All eligible literature published up to July 2016 were identified by searching Pubmed, Embase, Web of Science and CNKI. Pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated using a fixed or random effects model...
2017: PloS One
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