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https://www.readbyqxmd.com/read/28812968/jnk-pathway-in-osteoarthritis-pathological-and-therapeutic-aspects
#1
Hong-Xing Ge, Fu-Man Zou, Yan Li, An-Min Liu, Min Tu
CONTEXT: Osteoarthritis (OA) is a common chronic degenerative joint disease resulting in physical disability and reduced quality of life. Different biochemical signaling pathways are involved in the progression of OA, including the c-Jun NH2-terminal kinase (JNK) signal transduction pathway. OBJECTIVE: In this study, we have reviewed the recent updates on the association of JNK pathway with OA. METHODS: In this review, we have explored the databases like PubMed, Google Scholar, Medline, Scopus, etc...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28812699/primate-brain-size-is-predicted-by-diet-but-not-sociality
#2
Alex R DeCasien, Scott A Williams, James P Higham
The social brain hypothesis posits that social complexity is the primary driver of primate cognitive complexity, and that social pressures ultimately led to the evolution of the large human brain. Although this idea has been supported by studies indicating positive relationships between relative brain and/or neocortex size and group size, reported effects of different social and mating systems are highly conflicting. Here, we use a much larger sample of primates, more recent phylogenies, and updated statistical techniques, to show that brain size is predicted by diet, rather than multiple measures of sociality, after controlling for body size and phylogeny...
March 27, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812541/systematic-review-of-interventions-for-treating-or-preventing-antipsychotic-induced-tardive-dyskinesia
#3
Hanna Bergman, Dawn-Marie Walker, Adriani Nikolakopoulou, Karla Soares-Weiser, Clive E Adams
BACKGROUND: Antipsychotic medication can cause tardive dyskinesia (TD) - late-onset, involuntary, repetitive movements, often involving the face and tongue. TD occurs in > 20% of adults taking antipsychotic medication (first-generation antipsychotics for > 3 months), with this proportion increasing by 5% per year among those who continue to use these drugs. The incidence of TD among those taking newer antipsychotics is not different from the rate in people who have used older-generation drugs in moderate doses...
August 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28812213/heterogeneity-in-the-beta-cell-population-a-guided-search-into-its-significance-in-pancreas-and-in-implants
#4
REVIEW
Daniel Pipeleers, Ines De Mesmaeker, Thomas Robert, Freya Van Hulle
PURPOSE OF REVIEW: Intercellular differences in function have since long been noticed in the pancreatic beta-cell population. Heterogeneity in cellular glucose responsiveness is considered of physiological and pathological relevance. The present review updates evidence for the physiologic significance of beta-cell heterogeneity in the pancreas. It also briefly discusses what this role would imply for beta-cell implants in diabetes. RECENT FINDINGS: Over the past 3 years, functionally different beta cells have been related to mechanisms that may underlie their heterogeneity in the pancreas, such as the stage in their life cycle and the degree of their clustering to islets with varying vascularization...
August 15, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28812144/-trends-in-ablation-surgery-what-has-changed-compared-to-2001
#5
C V Fischer, M Kulanga, H Hoerauf
INTRODUCTION: In 2001 a survey among retinal surgeons regarding the treatment of rhegmatogenous retinal detachment either with scleral buckling methods or primary vitrectomy was performed. Due to the technical progress of vitrectomy and observational systems, it seemed appropriate to renew and update this survey supplemented with current aspects. METHODS: In this study 78 vitreoretinal surgeons from German-speaking countries were surveyed via an anonymous online questionnaire on their treatment decisions for defined retinal detachment constellations...
August 15, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28812059/clinician-s-update-on-the-benign-premalignant-and-malignant-skin-tumours-of-the-vulva-the-dermatologist-s-view
#6
REVIEW
Freja Lærke Sand, Simon Francis Thomsen
Correct and rapid diagnosis of skin tumours often requires biopsy and histopathological examination to differentiate benign lesions such as seborrhoeic keratoses or melanocytic naevi from premalignant and malignant lesions such as malignant melanoma. Particularly, to the untrained eye, any benign skin tumour-pigmented or nonpigmented-is easily mistaken for a malignant lesion. Qualified clinical evaluation is paramount in order to reduce the frequency of unwarranted skin biopsies. Herein, the most common benign, premalignant, and malignant vulvar skin tumours are reviewed...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28811916/drug-information-update-atypical-antipsychotics-and-neuroleptic-malignant-syndrome-nuances-and-pragmatics-of-the-association
#7
Siddharth Sarkar, Nitin Gupta
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal adverse event associated with the use of antipsychotics. Although atypical antipsychotics were initially considered to carry no risk of NMS, reports have accumulated over time implicating them in NMS causation. Almost all atypical antipsychotics have been reported to be associated with NMS. The clinical profile of NMS caused by certain atypical antipsychotics such as clozapine has been reported to be considerably different from the NMS produced by typical antipsychotics, with diaphoresis encountered more commonly, and rigidity and tremor encountered less frequently...
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28811849/meniere-s-disease-and-vestibular-migraine-updates-and-review-of-the-literature
#8
REVIEW
Paul Tabet, Issam Saliba
The diagnosis of Meniere's disease (MD) and vestibular migraine (VM) is primarily based on clinical criteria and their differentiation is often difficult. Currently, there are no known definitive diagnostic tests that can reliably distinguish the two conditions. Patients with MD and patients with VM are treated differently, therefore improving the diagnosis of these two pathologies should avoid errors in management. A systematic review was conducted according to PRISMA guidelines. Medline-Ovid and Embase databases were used to conduct a thorough search of English-language publications dating from 1948 to March 2016...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28811705/colorectal-cancer-screening-an-updated-review-of-the-available-options
#9
REVIEW
Iyad A Issa, Malak Noureddine
Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. However, colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless, in some parts of the world, CRC incidence and mortality remain on the rise, likely due to factors including "westernized" diet, lifestyle, and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28811394/overview-and-current-management-of-computerized-adaptive-testing-in-licensing-certification-examinations
#10
Dong Gi Seo
Computerized adaptive testing (CAT) has been implemented in the high stakes examinations such as National Council Licensure Examination-Registered Nurses (NCLEX-RN) in the United States since 1994. After that, The National Registry Emergency Medical Technician (NREMT) in the United States adopted a CAT to certify an Emergency Medical Technician (EMT) in 2007. It aimed at introducing CAT for the implementation in the medical health licensing examinations. Most CATs are based on the item response theory (IRT) which hypothesizes that both examinee and item has own characteristics that does not change...
July 26, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28811355/evidence-for-updating-the-core-domain-set-of-outcome-measures-for-juvenile-idiopathic-arthritis-report-from-a-special-interest-group-at-omeract-2016
#11
Esi M Morgan, Meredith P Riebschleger, Jennifer Horonjeff, Alessandro Consolaro, Jane E Munro, Susan Thornhill, Timothy Beukelman, Hermine I Brunner, Emily L Creek, Julia G Harris, Daniel B Horton, Daniel J Lovell, Melissa L Mannion, Judyann C Olson, Homaira Rahimi, Maria Chiara Gallo, Serena Calandra, Angelo Ravelli, Sarah Ringold, Susan Shenoi, Jennifer Stinson, Karine Toupin-April, Vibeke Strand, Clifton O Bingham
OBJECTIVE: The current Juvenile Idiopathic Arthritis (JIA) Core Set was developed in 1997 to identify the outcome measures to be used in JIA clinical trials using statistical and consensus-based techniques, but without patient involvement. The importance of patient/parent input into the research process has increasingly been recognized over the years. An Outcome Measures in Rheumatology (OMERACT) JIA Core Set Working Group was formed to determine whether the outcome domains of the current core set are relevant to those involved or whether the core set domains should be revised...
August 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28811353/the-omeract-rheumatoid-arthritis-magnetic-resonance-imaging-mri-scoring-system-updated-recommendations-by-the-omeract-mri-in-arthritis-working-group
#12
Mikkel Østergaard, Charles G Peterfy, Paul Bird, Frédérique Gandjbakhch, Daniel Glinatsi, Iris Eshed, Espen A Haavardsholm, Siri Lillegraven, Pernille Bøyesen, Bo Ejbjerg, Violaine Foltz, Paul Emery, Harry K Genant, Philip G Conaghan
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. METHODS: MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies...
August 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28811201/the-unmet-need-in-rheumatology-reports-from-the-targeted-therapies-meeting-2017
#13
Kevin L Winthrop, Vibeke Strand, Désirée van der Heijde, Philip Mease, Mary Crow, Michael Weinblatt, Joan Bathon, Gerd R Burmester, Maxime Dougados, Johnathan Kay, Xavier Mariette, Ronald Van Vollenhoven, Joachim Sieper, Fritz Melchers, Ferdinand C Breedfeld, Joachim Kalden, Josef S Smolen, Daniel E Furst
The 19th annual international Targeted Therapies meeting brought together over 100 leading basic scientists and clinical researchers from around the world in the field of immunology, molecular biology and rheumatology and other specialties. During the meeting, breakout sessions were held consisting of 5 disease-specific groups with 20-40 experts assigned to each group based on clinical or scientific expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematous, connective tissue diseases (e...
August 12, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28811194/immunogenetic-studies-of-the-hepatitis-c-virus-infection-in-an-era-of-pan-genotype-antiviral-therapies-effective-treatment-is-coming
#14
Joel Henrique Ellwanger, Valéria de Lima Kaminski, Jacqueline Maria Valverde-Villegas, Daniel Simon, Vagner Ricardo Lunge, José Artur Bogo Chies
What are the factors that influence human hepatitis C virus (HCV) infection, hepatitis status establishment, and disease progression? Firstly, one has to consider the genetic background of the host and HCV genotypes. The immunogenetic host profile will reflect how each infected individual deals with infection. Secondly, there are environmental factors that drive susceptibility or resistance to certain viral strains. These will dictate (I) the susceptibility to infection; (II) whether or not an infected person will promote viral clearance; (III) the immune response and the response profile to therapy; and (IV) whether and how long it would take to the development of HCV-associated diseases, as well as their severity...
August 12, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28810986/cancer-incidence-among-patients-of-the-u-s-veterans-affairs-health-care-system-2010-update
#15
Leah L Zullig, Kellie J Sims, Rebecca McNeil, Christina D Williams, George L Jackson, Dawn Provenzale, Michael J Kelley
INTRODUCTION: Nearly 50,000 incident cancer cases are reported in Veterans Affairs (VA) Central Cancer Registry (VACCR) annually. This article provides an updated report of cancer incidence recorded in VACCR. MATERIALS AND METHODS: Data were obtained from VACCR for incident cancers diagnosed in the VA health care system, focusing on 2010 data. Cancer incidence among VA patients is described by anatomical site, sex, race, stage, and geographic location, and was compared to the general U...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810679/association-of-endotoxin-and-allergens-with-respiratory-and-skin-symptoms-a-descriptive-study-in-laboratory-animal-workers
#16
Anne Oppliger, Fabio Barresi, Marion Maggi, Peter Schmid-Grendelmeier, Francois Huaux, Philipp Hotz, Holger Dressel
Background: In laboratory animal work, allergens are classically considered to play a prominent role in generation of respiratory and skin symptoms. However, recent development may have changed working conditions and require an updating of preventive measures. Objective: In workers exposed to a range of animals besides laboratory mice and rats the relative role of endotoxin, irritants, and allergens in symptom generation was assessed for updating preventative measures and health surveillance...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28810511/estimation-of-the-proximity-of-private-domestic-wells-to-underground-storage-tanks-oklahoma-pilot-study
#17
James W Weaver, Andrew R Murray, Fran V Kremer
For protecting drinking water supplies, the locations of areas with reliance on private domestic wells (hereafter referred to as "wells") and their relationship to contaminant sources need to be determined. A key resource in the U.S. was the 1990 Census where the source of domestic drinking water was a survey question. Two methods are developed to update estimates of the areal density of well use using readily accessible data. The first uses well logs reported to the states and the addition of housing units reported to the Census Bureau at the county, census tract and census block group scales...
August 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28810270/the-personal-antipsychotic-choice-index
#18
Floor van Dijk, Iris de Wit, Matthijs Blankers, Iris Sommer, Lieuwe de Haan
Introduction We present an online decision aid to involve patients with a psychotic disorder in shared decision-making concerning the selection of antipsychotic medication. Method Patients selected effectiveness and adverse effects criteria from the Subject's Response to Antipsychotics-34 questionnaire. Numerical data from meta-analyses, clinical trial data, receptor affinities and expert opinions were used to rank antipsychotics on each criterion. When using the the tool, patients indicate on a 5-point Likert scale how they value each (adverse) effect...
August 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28810091/preoperative-chest-radiography-in-elective-surgery-review-and-update
#19
Ethan M Young, Joel D Farmer
INTRODUCTION: The preoperative evaluation is designed to identify factors that may predispose a patient to perioperative complications in an effort to ensure patient safety. The use of chest radiography in the preoperative evaluation has progressed from routine testing to a more selective approach based on evidence that routine testing is low yield. However, preoperative chest radiography (POCR) may still be utilized more frequently than necessary as guidelines provide varying recommendations and providers continue to order the test by convention...
February 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28809991/treatment-of-inverse-intertriginous-psoriasis-updated-guidelines-from-the-medical-board-of-the-national-psoriasis-foundation
#20
Hasan Khosravi, Michael P Siegel, Abby S Van Voorhees, Joseph F Merola
<p>Inverse or intertriginous psoriasis commonly involves skin fold areas including the axillae, perianal skin, intergluteal cleft, inframammary, genital/inguinal, abdominal, and retroauricular folds. After reviewing the literature for new treatments, a task force was convened to update a consensus on inverse psoriasis therapy. Short-term treatment continues to be low-potency topical steroids. In order to avoid steroid-induced adverse effects, long-term therapy includes topical immunomodulators, calcitriol, and calcipotriene...
August 1, 2017: Journal of Drugs in Dermatology: JDD
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