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https://www.readbyqxmd.com/read/28929470/-sleep-apnoea-hypopnoea-syndrome-and-narcolepsy-description-of-a-series-of-hospital-patients
#1
M J Abenza-Abildua, V Lores-Gutierrez, M T Ramirez-Prieto, A Miralles-Martinez, M Prieto-Palacio, G Cordero-Martin, C Algarra-Lucas, A Gomez-Acena, C Jimeno-Montero, G Gutierrez-Cueto, E Macon-Liquete, B Bathal-Guede, J A Garcia-De Gregorio, A Perez-Villena, M L Herreros-Fernandez, F J Arpa-Gutierrez
INTRODUCTION: Sleep disorders are highly prevalent among the general population, although very few cases of sleep apnoea-hypopnoea syndrome (SAHS) have been reported in patients with narcolepsy. This study reviews the sleep disorders found in patients with narcolepsy, the prevalence of SAHS associated with these patients and their response to the different treatments. PATIENTS AND METHODS: We conducted an observation-based retrospective descriptive analysis of 25 patients diagnosed with narcolepsy, who were treated in our centre between October 2012 and December 2016...
October 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28917979/plantar-reflex-excitability-is-increased-in-the-evening-in-restless-legs-syndrome-patients
#2
Chloe Dafkin, Andrew Green, Benita Olivier, Warrick McKinon, Samantha Kerr
OBJECTIVE: To investigate if diurnal changes in spinal excitability (plantar reflex) occur in restless legs syndrome (RLS) participants compared to healthy matched controls. METHODS: Thirteen RLS participants and 13 healthy control participants' plantar reflex responses were evaluated in the evening (PM) and the morning (AM). Plantar reflex responses were assessed electromyographically, using motion analysis (kinematically) and by subjective nociception (Visual Analogue Scale)...
September 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28899525/restless-legs-syndrome-after-high-risk-tia-and-minor-stroke-association-with-reduced-quality-of-life
#3
Mark I Boulos, Anthony Wan, Sandra E Black, Andrew S Lim, Richard H Swartz, Brian J Murray
BACKGROUND: Restless legs syndrome (RLS) is a movement disorder that is associated with poor quality of life and depressive symptoms in the general population. Emerging evidence suggests that RLS is closely associated with cerebrovascular disease. We assessed the effect of RLS on quality of life after stroke and transient ischemic attack (TIA). METHODS: In this single-center prospective study, we recruited patients within 14 days of high-risk TIA or minor stroke...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28899286/restless-legs-syndrome-related-to-hemorrhage-of-a-thoracic-spinal-cord-cavernoma
#4
Malik Hamdaoui, Elisabeth Ruppert, Henri Comtet, Ulker Kilic-Huck, Valérie Wolff, Marc Bataillard, Patrice Bourgin
CONTEXT: Restless legs syndrome (RLS) is a common neurological disorder characterized by an irresistible urge to move the lower limbs often accompanied by unpleasant sensations in the legs, worsened at rest and in the evening. Symptoms are improved by movement. Its pathophysiology remains poorly understood. Lesion-related RLS has been reported, mainly in cases of stroke-related RLS involving the brainstem and lenticulostriate nuclei. Only few data of RLS in a context of spinal cord injury have been reported...
September 12, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28888928/an-update-on-new-and-unique-uses-of-botulinum-toxin-in-movement-disorders
#5
Joseph Jankovic
The therapeutic applications of botulinum toxin (BoNT) have grown manifold since its initial approval in 1989 by the US Food and Drug Administration (FDA) for the treatment of strabismus, blepharospasm, and other facial spasms. Although it is the most potent biologic toxin known to man, long-term studies have established its safety in the treatment of a variety of neurologic and non-neurologic disorders. This review focuses on some novel and uncommon uses of BoNT in the treatment of movement disorders, such as oromandibular dystonia, including bruxism, anterocollis, camptocormia, tremor, tics, tardive and levodopa-induced dyskinesia, and restless legs syndrome...
September 6, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28853423/daytime-sleepiness-more-than-just-obstructive-sleep-apnea-osa
#6
Luigi Ferini-Strambi, Marco Sforza, Mattia Poletti, Federica Giarrusso, Andrea Galbiati
Excessive Daytime Sleepiness (EDS) is a common condition with a significant impact on quality of life and general health. A mild form of sleepiness can be associated with reduced reactivity and modest distractibility symptoms, but more severe symptomatic forms are characterized by an overwhelming and uncontrollable need to sleep, causing sudden sleep attacks, amnesia and automatic behaviors. The prevalence in the general population is between 10 and 25%. Furthermore, EDS has been considered a core symptom of obstructive sleep apnea (OSA), as well as being the main symptom of primary hypersomnias such as narcolepsy types 1 and 2, and idiopathic hypersomnia...
August 28, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28852150/targeted-disruption-of-supraspinal-motor-circuitry-reveals-a-distributed-network-underlying-restless-legs-syndrome-rls-like-movements-in-the-rat
#7
Chun-Ni Guo, Wen-Jia Yang, Shi-Qin Zhan, Xi-Fei Yang, Michael C Chen, Patrick M Fuller, Jun Lu
In this study we uncovered, through targeted ablation, a potential role for corticospinal, cerebello-rubro-spinal, and hypothalamic A11 dopaminergic systems in the development of restless legs syndrome (RLS)-like movements during sleep. Targeted lesions in select basal ganglia (BG) structures also revealed a major role for nigrostriatal dopamine, the striatum, and the external globus pallidus (GPe) in regulating RLS-like movements, in particular pallidocortical projections from the GPe to the motor cortex. We further showed that pramipexiole, a dopamine agonist used to treat human RLS, reduced RLS-like movements...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28843017/motor-hyperactivity-of-the-iron-deficient-rat-an-animal-model-of-restless-legs-syndrome
#8
Yuan-Yang Lai, Yu-Hsuan Cheng, Kung-Chiao Hsieh, Darian Nguyen, Keng-Tee Chew, Lalini Ramanathan, Jerome M Siegel
BACKGROUND: Abnormal striatal dopamine transmission has been hypothesized to cause restless legs syndrome. Dopaminergic drugs are commonly used to treat restless legs syndrome. However, they cause adverse effects with long-term use. An animal model would allow the systematic testing of potential therapeutic drugs. A high prevalence of restless legs syndrome has been reported in iron-deficient anemic patients. We hypothesized that the iron-deficient animal would exhibit signs similar to those in restless legs syndrome patients...
August 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28837991/the-role-of-iron-in-pediatric-restless-legs-syndrome-and-periodic-limb-movements-in-sleep
#9
Tiffany Munzer, Barbara Felt
No abstract text is available yet for this article.
August 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28831753/pharmacological-management-of-restless-legs-syndrome-and-periodic-limb-movement-disorder-in-children
#10
Geoffrey Rulong, Thomas Dye, Narong Simakajornboon
Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) are under-recognized sleep disorders in children and adolescents. Several recent epidemiological studies have shown that RLS and PLMD are common in the pediatric population, and if left untreated, may lead to cardiovascular and neurocognitive consequences. Therefore, early diagnosis and intervention may help preventing long-term consequences. The management of RLS and PLMD in children involves both non-pharmacologic and pharmacologic approaches...
August 22, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28822709/the-influence-of-antidepressants-on-restless-legs-syndrome-and-periodic-limb-movements-a-systematic-review
#11
REVIEW
Bhanu Prakash Kolla, Meghna P Mansukhani, J Michael Bostwick
Restless legs syndrome is commonly co-morbid with medical conditions that are treated with antidepressant medications, such as depression, anxiety, fibromyalgia, and chronic insomnia disorder. Evidence from case reports and cross-sectional studies suggests that antidepressants may induce or worsen restless legs syndrome and increase periodic limb movements. We undertook a systematic review of the literature to identify and collate all prospective studies that measured restless legs syndrome symptoms and/or periodic limb movements following the introduction of an antidepressant...
June 15, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28802939/sleep-dysfunction-in-parkinson-s-disease
#12
Cristian Falup-Pecurariu, Ştefania Diaconu
The spectrum of sleep problems in Parkinson's disease (PD) is broad. These symptoms are recognized as being clinically relevant by the PD patients and may seriously affect their quality of life. Some studies reveal the occurrence of sleep disorders in more than half of the PD patients. The etiology is multifactorial and it mainly involves the degeneration of the sleep-regulating structures. Sleep disorders in PD can be classified into: disturbances of sleep and disturbances of wakefulness. Generic and specific scales were designed to help the screening and evaluation of sleep dysfunction...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28799704/the-nature-consequences-and-management-of-neurological-disorders-in-chronic-kidney-disease
#13
REVIEW
Bahman Jabbari, Nosratola D Vaziri
Perhaps no other organ in the body is affected as often and in as many ways as the brain is in patients with chronic kidney disease (CKD). Several factors contribute to the neurological disorders in CKD including accumulation of uremic toxins, metabolic and hemodynamic disorders, oxidative stress, inflammation, and impaired blood brain barrier among others. The neurological disorders in CKD involve both peripheral and central nervous system. The peripheral neurological symptoms of CKD are due to somatic and cranial peripheral neuropathies as well as a myopathy...
August 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28777180/sleep-wake-disorders-of-childhood
#14
Suresh Kotagal
PURPOSE OF REVIEW: Sleep-wake disorders occur in 10% to 28% of children and differ somewhat in pathophysiology and management from sleep-wake disorders in adults. This article discusses the diagnosis and management of key childhood sleep disorders. RECENT FINDINGS: The role of sleep in memory consolidation and in the facilitation of learning has been increasingly recognized, even at the toddler stage. Cataplexy, a key feature of narcolepsy type 1, may be subtle in childhood and characterized by transient muscle weakness isolated to the face...
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28777179/comorbid-sleep-disturbances-in-neurologic-disorders
#15
Yo-El S Ju, Aleksandar Videnovic, Bradley V Vaughn
PURPOSE OF REVIEW: This article provides a review of disturbances of sleep comorbid with common neurologic disorders. RECENT FINDINGS: A wide variety of neurologic disorders are frequently complicated by comorbid sleep disturbances. In many cases, a bidirectional relationship appears to occur between sleep function and the neurologic disease, such that treatment of comorbid sleep disturbances may improve the symptoms of the neurologic disease. SUMMARY: Neurologic disorders are often associated with abnormalities of sleep...
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28777173/restless-legs-syndrome-and-sleep-related-movement-disorders
#16
Lynn Marie Trotti
PURPOSE OF REVIEW: This article provides an update on six sleep-related movement disorders: restless legs syndrome (RLS), periodic limb movement disorder, sleep-related leg cramps, bruxism, rhythmic movement disorder, and propriospinal myoclonus, with an emphasis on RLS. RECENT FINDINGS: RLS is a common sensorimotor disorder that impairs quality of life. RLS is frequently comorbid to neurologic, psychiatric, vascular, and inflammatory diseases. Accumulating evidence implicates the pathophysiology of RLS as a state of dopamine dysfunction and iron deficiency that occurs on a background of genetic susceptibility conferred by 6 gene polymorphisms...
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28777171/diagnostic-approach-and-investigation-in-sleep-medicine
#17
Michael H Silber
PURPOSE OF REVIEW: This article provides a clinical approach to the appropriate investigation and diagnosis of sleep disorders commonly seen by neurologists. RECENT FINDINGS: Home sleep apnea testing in appropriate situations can replace laboratory polysomnography in many cases of uncomplicated sleep apnea. Multiple sleep latency tests must be performed meticulously and interpreted in the clinical setting to avoid overdiagnoses of narcolepsy. Human leukocyte antigen testing has limited utility in establishing a diagnosis of narcolepsy because a positive test has low specificity...
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28752613/sleep-patterns-among-patients-with-chronic-fatigue-a-polysomnography-based-study
#18
Evelina Pajediene, Indre Bileviciute-Ljungar, Danielle Friberg
OBJECTIVES: The purpose of this study was to detect treatable sleep disorders among patients complaining of chronic fatigue by using sleep questionnaires and polysomnography. METHODS: Patients were referred to hospital for investigations and rehabilitation because of a suspected diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The criteria for further referral to full-night polysomnography (PSG) were symptoms of excessive daytime sleepiness and/or tiredness in the questionnaires...
July 28, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28728619/restless-genital-syndrome-differential-diagnosis-and-treatment-with-pramipexole
#19
Emilia Sforza, David Hupin, Frédéric Roche
Restless genital syndrome refers to excessive and persistent sensations of genital and clitoral arousal with the absence of conscious feeling of sexual desire. These sensations have been linked to symptoms of restless legs syndrome (RLS) or an overactive bladder. Restless genital syndrome may be related to small fiber sensory neuropathy of the dorsal nerve of the clitoris, so it more frequently occurs in women. The association with RLS suggests a possible dopaminergic mechanism. We report a case of a 74-year-old woman who presented restless genital symptoms every night in association with RLS symptoms...
September 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28682991/the-effect-of-cold-dialysis-in-motor-and-sensory-symptoms-of-rls-wed-occurring-during-hemodialysis-a-double-blind-study
#20
Giorgos K Sakkas, Evaggelia Tsaknaki, Clara S Rosa, Christoforos D Giannaki, Argyro A Krase, Eleftherios Lavdas, Georgios M Hadjigeorgiou, Ioannis Stefanidis, Christina Karatzaferi
Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a common sensorimotory disorder affecting almost 30% of hemodialysis (HD) patients. RLS/WED induces discomfort during rest hours, and its symptoms have also been observed during HD sessions. Anecdotal reports suggest that cooling the dialysate solution during dialysis could help patients overcome those symptoms and improve restlessness. The aim of this double-blind study was to assess whether a reduction of the dialysate temperature by 1°C could reduce motor and sensory symptoms of RLS/WED occurring during HD...
July 4, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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