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https://www.readbyqxmd.com/read/28626420/restless-legs-syndrome-from-pathophysiology-to-clinical-diagnosis-and-management
#1
REVIEW
Shiyi Guo, Jinsha Huang, Haiyang Jiang, Chao Han, Jie Li, Xiaoyun Xu, Guoxin Zhang, Zhicheng Lin, Nian Xiong, Tao Wang
Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western countries, has gained more and more attention in Asian countries. The prevalence of RLS is higher in older people and females. RLS is most commonly related to iron deficiency, pregnancy and uremia. The RLS symptoms show a significant circadian rhythm and a close relationship to periodic limb movements (PLMs) in clinical observations, while the pathophysiological pathways are still unknown. The diagnostic criteria have been revised in 2012 to improve the validity of RLS diagnosis...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28620941/endothelial-mechanotransduction-proteins-and-vascular-function-are-altered-by-dietary-sucrose-supplementation-in-healthy-young-male-subjects
#2
Lasse Gliemann, Nicolai Rytter, Mads Lindskrog, Martina H Lundberg Slingsby, Thorbjörn Åkerström, Lykke Sylow, Erik A Richter, Ylva Hellsten
Endothelial mechanotransduction is important for vascular function but alterations and activation of vascular mechanosensory proteins have not been investigated in humans. In endothelial cell culture, simple sugars effectively impair mechanosensor proteins. To study mechanosensor- and vascular function in humans, twelve young healthy male subjects supplemented their diet with 3 × 75 g sucrose day(-1) for 14 days in a randomized cross-over design. Before and after the intervention period, the hyperemic response to passive lower leg movement and active knee extensor exercise was determined by ultrasound doppler...
June 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28556500/evaluation-of-sleep-quality-in-patients-with-ankylosing-spondylitis-and-efficacy-of-anti-tnf-%C3%AE-therapy-on-sleep-problems-a-polisomnographic-study
#3
Gulsah Karatas, Ajda Bal, Melike Yuceege, Hikmet Firat, Eda Gurcay, Sadik Ardic, Fatma Aytul Cakci
INTRODUCTION: This study was conducted to investigate the relationship between sleep quality (SQ) and disease activity (DA) in patients with ankylosing spondylitis (AS) and to evaluate the response to anti-tumor necrosis factor α (anti-TNF-α) therapy on sleep disorders. MATERIALS AND METHODS: A total of 34 patients who met the modified New York classification criteria for AS were included in this prospective study. Patients were divided into two groups as follows: Group I (n = 15) with high DA and receiving anti-TNF-α therapy, and Group II (n = 19) in remission...
May 29, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28522077/treatment-of-restless-legs-syndrome-with-the-selective-ampa-receptor-antagonist-perampanel
#4
Diego Garcia-Borreguero, Irene Cano, Juan Jose Granizo
OBJECTIVES: Perampanel is a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) antagonist that has been approved for the treatment of partial seizures. Here we report on the first open study evaluating its efficacy in idiopathic restless legs syndrome (RLS). METHODS: The study was designed as a prospective two-month open trial. Twenty-two previously untreated patients diagnosed with idiopathic RLS began treatment with 2 mg perampanel, which was increased to 4 mg at week four if clinically necessary...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28464758/periodic-limb-movements-in-tetraplegia
#5
Annemieke Emma Josina Peters, Lysanne van Silfhout, Marnie Graco, Rachel Schembri, Dick Thijssen, David J Berlowitz
OBJECTIVE: To establish the prevalence of Periodic Limb Movements during Sleep (PLMS) in patients with tetraplegia, controlling for obstructive sleep apnea. To explore whether demographic and injury characteristics affect PLMS. STUDY DESIGN: Retrospective cohorts. SETTING AND PARTICIPANTS: One hundred seventy-three participants with acute (<12 months) and 92 with chronic (>12 months) tetraplegia who underwent full overnight diagnostic sleep studies...
May 2, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28455768/sleep-disturbance-in-mild-cognitive-impairment-a-systematic-review-of-objective-measures
#6
REVIEW
Mingyue Hu, Ping Zhang, Chen Li, Yongfei Tan, Guichen Li, Duo Xu, Li Chen
Sleep disturbance frequently occurs in patients with mild cognitive impairment (MCI) and appears to be involved in the cellular and molecular mechanisms of cognitive decline. The aim of this systematic review is to clarify whether patients with MCI demonstrate alterations in certain sleep parameters: total sleep time (TST), sleep efficiency (SE), sleep latency (SL), rapid eye movement latency (REML), percent of rapid eye movement (REM%), arousal index (AI), wake after sleep onset (WASO), slow-wave sleep (SWS), periodic leg movement in sleep (PLMS), and cyclic alternating pattern (CAP) through polysomnography (PSG) and actigraphy...
April 28, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28425489/meis1-variant-as-a-determinant-of-autonomic-imbalance-in-restless-legs-syndrome
#7
Jérôme Thireau, Charlotte Farah, Nicolas Molinari, Fabrice Bouilloux, Lucas Torreilles, Juliane Winkelmann, Sabine Scholz, Sylvain Richard, Yves Dauvilliers, Frédéric Marmigère
Restless Legs Syndrome (RLS) is a genetically complex neurological disorder in which overlapping genetic risk factors may contribute to the diversity and heterogeneity of the symptoms. The main goal of the study was to investigate, through analysis of heart rate variability (HRV), whether in RLS patients the MEIS1 polymorphism at risk influences the sympathovagal regulation in different sleep stages. Sixty-four RLS patients with periodic leg movement index above 15 per hour, and 38 controls underwent one night of video-polysomnographic recording...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28391285/while-isolated-periodic-limb-movement-disorder-significantly-impacts-sleep-depth-and-efficiency-co-morbid-restless-leg-syndrome-mainly-exacerbates-perceived-sleep-quality
#8
Florent-Xavier Hardy De Buisseret, Olivier Mairesse, Johan Newell, Paul Verbanck, Daniel Neu
BACKGROUND: Restless leg syndrome (RLS) and periodic limb movement (PLM) disorder (PLMD) can affect sleep quality and interfere with daytime functioning. Whether the co-morbidity of RLS further worsens daytime symptoms, sleep architecture and quality in patients with PLMs, is not yet fully clarified. METHODS: Sleep (polysomnography) and daytime symptoms of 47 drug-free patients, assigned to isolated PLMD or co-morbid RLS subgroups, were compared to controls in a retrospective cohort-study (n = 501)...
2017: European Neurology
https://www.readbyqxmd.com/read/28378384/short-interval-leg-movements-during-sleep-entail-greater-cardiac-activation-than-periodic-leg-movements-during-sleep-in-restless-legs-syndrome-patients
#9
Raffaele Ferri, Francesco Rundo, Alessandro Silvani, Marco Zucconi, Debora Aricò, Oliviero Bruni, Bartolo Lanuzza, Luigi Ferini-Strambi, Mauro Manconi
Periodic leg movements during sleep (PLMS) are sequences of ≥4 motor events with intermovement intervals (IMI) of 10-90 s. PLMS are a supportive diagnostic criterion for restless legs syndrome (RLS) and entail cardiac activation, particularly when associated with arousal. RLS patients also over-express short-interval leg movements during sleep (SILMS), which have IMI <10 s and are organized mainly in sequences of two movements (doublets). We tested whether the cardiac activation associated with SILMS doublets differs from that associated with PLMS in a sample of 25 RLS patients...
April 4, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28366347/sleep-disturbance-in-pediatric-patients-on-automated-peritoneal-dialysis
#10
Cláudia Gomes, Lia Oliveira, Rosário Ferreira, Carla Simão
OBJECTIVE: There are few reports describing sleep disturbance (SD) in children on automated peritoneal dialysis (APD), and they are mostly based on the application of questionnaires. As far as we know, only two studies used polysomnography (PSG), the gold standard for the diagnosis of SD. This is the first study assessing SD in children with chronic kidney disease (CKD) on APD in our country. METHODS: This was an observational and descriptive study. Children up to 18 years of age who had undergone APD for a minimum of three months were considered eligible...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28364468/intervening-leg-movements-disrupt-plms-sequences
#11
Kasidet Hiranniramol, Stephany Fulda, Patrick Skeba, Christopher J Earley, Richard P Allen
Study Objectives: Periodic leg movements during sleep (PLMS) occur within a subject as a series with a remarkably stable period defined by the intermovement interval (IMI). Sometimes a non-PLMS movement occurs intervening between two PLMS. PLMS scoring rules totally ignore these intervening leg movements (iLM). This implicitly assumes an iLM results from a process sufficiently independent from the periodic process producing PLMS that it does not affect the periodicity of the surrounding PLMS...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28349352/the-clinical-importance-of-periodic-leg-movements-in-sleep
#12
REVIEW
Michela Figorilli, Monica Puligheddu, Patrizia Congiu, Raffaele Ferri
Periodic leg movements during sleep (PLMS) are commonly found in patients with restless leg syndrome (RLS), but they may occur in other sleep disorders and several medical conditions. Their prevalence increases with age, but they can also be observed in children. During the last decades, very active research has been devoted to determine and understand the pathophysiology, associated events, and clinical significance of PLMS. This chapter tries to sum up the most relevant PLMS-related findings, focusing on the relationship between PLMS and the cardiovascular system, in order to understand the clinical implication of this complex motor phenomenon...
March 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28341521/periodic-leg-movements-during-sleep-phenotype-neurophysiology-and-clinical-significance
#13
REVIEW
Raffaele Ferri, Brian B Koo, Daniel L Picchietti, Stephany Fulda
Periodic leg movements during sleep (PLMS) are the most important objective finding in restless legs syndrome (RLS). During the last decade, PLMS have been very important for the assessment and comprehension of their pathophysiological correlates, which have been paralleled by the emergence of new computer-assisted and data-driven rules for their identification, scoring, and analysis. The present article focused on the most relevant PLMS-related findings of the last decade, and sought to provide a coherent and comprehensive overview on this enigmatic motor phenomenon...
March 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28329227/incident-cardiovascular-events-and-death-in-individuals-with-restless-legs-syndrome-or-periodic-limb-movements-in-sleep-a-systematic-review
#14
Tetyana Kendzerska, Maneesha Kamra, Brian J Murray, Mark I Boulos
Study Objectives: To systematically review the current evidence examining restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) as prognostic factors for all-cause mortality and incident cardiovascular events (CVE) in longitudinal studies published in the adult population. Methods: All English language studies (from 1947 to 2016) found through Medline and Embase, as well as bibliographies of identified articles, were considered eligible. Quality was evaluated using published guidelines...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28285142/effects-of-hip-abduction-and-adduction-accuracy-on-post-stroke-gait
#15
Jesse C Dean, Aaron E Embry, Katy H Stimpson, Lindsay A Perry, Steven A Kautz
BACKGROUND: Gait instability often limits post-stroke function, although the mechanisms underlying this instability are not entirely clear. Our recent work has suggested that one possible factor contributing to post-stroke gait instability is a reduced ability to accurately control foot placement. The purpose of the present experiments was to investigate whether post-stroke gait function is related to the ability to accurately abduct and adduct the hip, as required for accurate foot placement...
May 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28279575/should-oral-iron-be-first-line-therapy-for-pediatric-restless-legs-syndrome-and-periodic-limb-movement-disorder
#16
EDITORIAL
Daniel L Picchietti
No abstract text is available yet for this article.
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28268364/3d-detection-of-periodic-limb-movements-in-sleep
#17
Heinrich Garn, Bernhard Kohn, Klaus Dittrich, Christoph Wiesmeyr, Gerhard Kloesch, Robert Stepansky, Markus Wimmer, Osman Ipsiroglu, Dieter Grossegger, Manuel Kemethofer, Stefan Seidel
The standard polysomnographic method for detecting periodic limb movements in sleep (PLMS) includes measuring the electromyography (EMG) signals from electrodes at the left and right tibialis anterior muscles. This procedure has disadvantages as the cabling affects the patients quality of sleep and the electrodes tend to come off during the night, deteriorating data quality. We used contactless monitoring of body movements by a 3D time-of-flight camera mounted above the bed. Changes in the 3D silhouette indicate motion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28259410/the-use-of-infrared-thermography-and-accelerometers-for-remote-monitoring-of-dairy-cow-health-and-welfare
#18
M Stewart, M T Wilson, A L Schaefer, F Huddart, M A Sutherland
Increasing reliance on automated systems on-farm has led to a need for remote monitoring of health and welfare. We aimed to validate 2 methods that could be integrated into automated systems currently in use: infrared thermography (IRT) to measure respiration rate (RR), and accelerometers to measure the flinch, step, kick (FSK) response and assessing stress and discomfort. We monitored 22 multiparous, nonlactating, Friesian and Friesian × Jersey cows (average 5.1 yr of age) during a baseline period (2 min), a restraint in a crush (2 min), and then a recovery period after exposure to a startle (2 min)...
May 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28243157/big-data-in-sleep-medicine-prospects-and-pitfalls-in-phenotyping
#19
Matt T Bianchi, Kathryn Russo, Harriett Gabbidon, Tiaundra Smith, Balaji Goparaju, M Brandon Westover
Clinical polysomnography (PSG) databases are a rich resource in the era of "big data" analytics. We explore the uses and potential pitfalls of clinical data mining of PSG using statistical principles and analysis of clinical data from our sleep center. We performed retrospective analysis of self-reported and objective PSG data from adults who underwent overnight PSG (diagnostic tests, n=1835). Self-reported symptoms overlapped markedly between the two most common categories, insomnia and sleep apnea, with the majority reporting symptoms of both disorders...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28226527/3d-detection-of-periodic-limb-movements-in-sleep
#20
Heinrich Garn, Bernhard Kohn, Klaus Dittrich, Christoph Wiesmeyr, Gerhard Kloesch, Robert Stepansky, Markus Wimmer, Osman Ipsiroglu, Dieter Grossegger, Manuel Kemethofer, Stefan Seidel, Heinrich Garn, Bernhard Kohn, Klaus Dittrich, Christoph Wiesmeyr, Gerhard Kloesch, Robert Stepansky, Markus Wimmer, Osman Ipsiroglu, Dieter Grossegger, Manuel Kemethofer, Stefan Seidel, Christoph Wiesmeyr, Gerhard Kloesch, Heinrich Garn, Osman Ipsiroglu, Manuel Kemethofer, Robert Stepansky, Dieter Grossegger, Klaus Dittrich, Markus Wimmer, Bernhard Kohn, Stefan Seidel
The standard polysomnographic method for detecting periodic limb movements in sleep (PLMS) includes measuring the electromyography (EMG) signals from electrodes at the left and right tibialis anterior muscles. This procedure has disadvantages as the cabling affects the patients quality of sleep and the electrodes tend to come off during the night, deteriorating data quality. We used contactless monitoring of body movements by a 3D time-of-flight camera mounted above the bed. Changes in the 3D silhouette indicate motion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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