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Yifan Cheng

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https://www.readbyqxmd.com/read/28591576/regulation-of-rvb1-rvb2-by-a-domain-within-the-ino80-chromatin-remodeling-complex-implicates-the-yeast-rvbs-as-protein-assembly-chaperones
#1
Coral Y Zhou, Caitlin I Stoddard, Jonathan B Johnston, Michael J Trnka, Ignacia Echeverria, Eugene Palovcak, Andrej Sali, Alma L Burlingame, Yifan Cheng, Geeta J Narlikar
The hexameric AAA+ ATPases Rvb1 and Rvb2 (Rvbs) are essential for diverse processes ranging from metabolic signaling to chromatin remodeling, but their functions are unknown. While originally thought to act as helicases, recent proposals suggest that Rvbs act as protein assembly chaperones. However, experimental evidence for chaperone-like behavior is lacking. Here, we identify a potent protein activator of the Rvbs, a domain in the Ino80 ATPase subunit of the INO80 chromatin-remodeling complex, termed Ino80INS...
June 6, 2017: Cell Reports
https://www.readbyqxmd.com/read/28559351/positive-impacts-of-early-auditory-training-on-cortical-processing-at-an-older-age
#2
Yuan Cheng, Guoqiang Jia, Yifan Zhang, Huanhuan Hao, Ye Shan, Liping Yu, Xinde Sun, Qingyin Zheng, Nina Kraus, Michael M Merzenich, Xiaoming Zhou
Progressive negative behavioral changes in normal aging are paralleled by a complex series of physical and functional declines expressed in the cerebral cortex. In studies conducted in the auditory domain, these degrading physical and functional cortical changes have been shown to be broadly reversed by intensive progressive training that improves the spectral and temporal resolution of acoustic inputs and suppresses behavioral distractors. Here we found older rats that were intensively trained on an attentionally demanding modulation-rate recognition task in young adulthood substantially retained training-driven improvements in temporal rate discrimination abilities over a subsequent 18-mo epoch-that is, forward into their older age...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28550250/frequency-dependent-changes-in%C3%A2-the%C3%A2-amplitude-of-low-frequency-fluctuations-in-mild-cognitive-impairment-with-mild-depression
#3
Yuxia Li, Bin Jing, Han Liu, Yifan Li, Xuan Gao, Yongqiu Li, Bin Mu, Haikuo Yu, Jinbo Cheng, Peter B Barker, Hongxing Wang, Ying Han
BACKGROUND: Depression is a potential marker of preclinical Alzheimer's disease (AD). However, little is known about the abnormal characteristics revealed by resting-state functional magnetic resonance imaging (rs-fMRI) in mild cognitive impairment (MCI) subjects with depressive symptoms (MCI-d). OBJECTIVE: The study was to examine whether abnormalities in amplitudes of low-frequency oscillation occurred in MCI-d and tried to find the possible spectrum showed higher recognition ability to the diagnosis by utilizing functional MRI (fMRI)...
May 26, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28525882/interfacially-crosslinked-composite-porous-membranes-for-ultrafast-removal-of-anionic-dyes-from-water-through-permeating-adsorption
#4
Cuijing Liu, Liang Cheng, Yifan Zhao, Liping Zhu
The dye wastewater is one of the most difficult industrial wastewaters to treat. It keeps a big challenge to realize fast removal of dyes from water by membrane filtration due to the trade-off between separation selectivity and permeation flux for ultrafiltration or nanofiltration (NF) process. Here we report novel composite porous membranes which can remove anionic dyes from water by ultrafast permeating adsorption. A crosslinked polyethyleneimine (PEI) polymer with strong adsorption ability was incorporated onto a nylon microfiltration membrane by the interfacial amidation reaction between PEI and trimesoyl chloride...
April 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28475341/plating-precious-metals-on-nonprecious-metal-nanoparticles-for-sustainable-electrocatalysts
#5
Lei Wang, Zhenhua Zeng, Cheng Ma, Yifan Liu, Michael Giroux, Miaofang Chi, Jian Jin, Jeffrey Greeley, Chao Wang
Precious metals have broad applications in modern industry and renewable energy technologies. The high cost and limited availability of these materials, however, have caused a grand challenge for sustainability. Here, we report on the plating of a precious metal on nonprecious metal nanoparticles for the development of sustainable electrocatalysts. Cobalt/platinum core/shell (denoted as Co@Pt) nanoparticles were synthesized via seed-mediated growth. The Co seeds were first synthesized by thermal decomposition of cobalt carbonyl, and the Pt shell was overgrown in situ by adding platinum acetylacetonate (Pt(acac)2)...
June 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28442357/dl-3-n-butylphthalide-promotes-neuroplasticity-and-motor-recovery-in-stroke-rats
#6
Yefei Sun, Xi Cheng, Huibin Wang, Xiaopeng Mu, Yifan Liang, YuJia Luo, Huiling Qu, Chuansheng Zhao
BACKGROUNDS AND AIMS: Racemic l-3-n-butylphthalide (dl-NBP), is able to achieve a functional recovery in animal models of cerebral ischemia, vascular dementia, and Alzheimer's disease. In this study, we investigated the effect of dl-NBP on axonal growth, neurogenesis and behavioral performances in rats with cerebral ischemia. METHODS: Focal cerebral ischemia in rats was produced by intracerebral injection of endothelin-1. Starting from postoperative day 7, the experimental rats were administered 70mg/kg dl-NBP by oral gavage for two weeks...
June 30, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28415707/luteolin-reduces-inflammation-in-staphylococcus-aureus-induced-mastitis-by-inhibiting-nf-kb-activation-and-mmps-expression
#7
Ying-Fang Guo, Nian-Nian Xu, Weijing Sun, Yifan Zhao, Cheng-Ye Li, Meng-Yao Guo
Mastitis is a serious and prevalent disease caused by infection by pathogens such as Staphylococcus aureus. We evaluated the anti-inflammatory effects and mechanism of luteolin, a natural flavonoid with a wide range of pharmacological activities, in a mouse model of S. aureus mastitis. We also treated cultured mouse mammary epithelial cells (mMECs) with S. aureus and luteolin. Histopathological changes were examined by H&E staining and the levels of inflammatory cytokine proteins were analyzed using ELISAs...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28262785/a-novel-ideal-radionuclide-imaging-system-for-non-invasively-cell-monitoring-built-on-baculovirus-backbone-by-introducing-sleeping-beauty-transposon
#8
Jing Lv, Yu Pan, Huijun Ju, Jinxin Zhou, Dengfeng Cheng, Hongcheng Shi, Yifan Zhang
Sleeping Beauty (SB) transposon is an attractive tool in stable transgene integration both in vitro and in vivo; and we introduced SB transposon into recombinant sodium-iodide symporter baculovirus system (Bac-NIS system) to facilitate long-term expression of recombinant sodium-iodide symporter. In our study, two hybrid baculovirus systems (Bac-eGFP-SB-NeoR and Bac-NIS-SB-NeoR) were successfully constructed and used to infect U87 glioma cells. After G418 selection screening, the Bac-eGFP-SB-NeoR-U87 cells remained eGFP positive, at the 18(th) and 196(th) day post transfection (96...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28250466/motioncor2-anisotropic-correction-of-beam-induced-motion-for-improved-cryo-electron-microscopy
#9
Shawn Q Zheng, Eugene Palovcak, Jean-Paul Armache, Kliment A Verba, Yifan Cheng, David A Agard
No abstract text is available yet for this article.
April 2017: Nature Methods
https://www.readbyqxmd.com/read/28191565/diverse-macroscopic-helical-motions-of-microribbons-driven-by-electrons
#10
Cheng Peng, Yifan Zhang, Yibin Zhang, Zichao Zhou, Yanke Che, Jincai Zhao
Novel stimuli-responsive microscale materials capable of undergoing diverse out-of-plane helical motions (e.g., bending, twisting and coiling) when exposed to electron irradiation are reported. The macroscopic morphological changes of microribbons induced by electrons arise from the combination of diagonal in-plane, non-bonded distortion relative to the long axis of the microribbon and vertical non-bonded distortion.
February 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28142057/the-effect-of-classical-swine-fever-virus-ns5a-and-ns5a-mutants-on-oxidative-stress-and-inflammatory-response-in-swine-testicular-cells
#11
Wang Dong, Huifang Lv, Yifan Wang, Xiaomeng Li, Cheng Li, Lu Wang, Chengbao Wang, Kangkang Guo, Yanming Zhang
Infection with classical swine fever virus (CSFV) results in highly significant economic losses; this infection is characterized by being highly contagious and accompanied by hyperthermia and systemic bleeding. Oxidative stress (OS) plays a critical role in the pathological process of viral infection. The function of the nonstructural protein 5A (NS5A) in the pathogenesis of CSFV has not been completely understood. Here, OS and the inflammatory response were studied with NS5A and substitution mutants in swine testicular (ST) cells...
January 13, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28038465/viral-host-interaction-in-kidney-reveals-strategies-to-escape-host-immunity-and-persistently-shed-virus-to-the-urine
#12
Xumin Ou, Sai Mao, Yifan Jiang, Shengyong Zhang, Chen Ke, Guangpeng Ma, Anchun Cheng, Mingshu Wang, Dekang Zhu, Shun Chen, Renyong Jia, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu, Xiaoyue Chen
Hepatitis A virus is one of five types of hepatotropic viruses that cause human liver disease. A similar liver disease is also identified in ducks caused by Duck Hepatitis A virus (DHAV). Notably, many types of hepatotropic viruses can be detected in urine. However, how those viruses enter into the urine is largely unexplored. To elucidate the potential mechanism, we used the avian hepatotropic virus to investigate replication strategies and immune responses in kidney until 280 days after infection. Immunohistochemistry and qPCR were used to detect viral distribution and copies in the kidney...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27901082/full-duplex-bidirectional-data-transmission-link-using-twisted-lights-multiplexing-over-1-1-km-orbital-angular-momentum-fiber
#13
Shi Chen, Jun Liu, Yifan Zhao, Long Zhu, Andong Wang, Shuhui Li, Jing Du, Cheng Du, Qi Mo, Jian Wang
We present a full-duplex bidirectional data transmission link using twisted lights multiplexing over 1.1-km orbital angular momentum (OAM) fiber. OAM+1 and OAM-1 modes carrying 20-Gbit/s quadrature phase-shift keying (QPSK) signals are employed in the downlink and uplink transmission experiments. The observed mode crosstalks are less than -15.2 dB, and the full-duplex crosstalks are less than -12.7 dB. The measured full-duplex optical signal-to-noise ratio (OSNR) penalties at a bit-error rate (BER) of 2 × 10(-3) are ~2...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895319/activation-of-chronic-toxoplasmosis-by-transportation-stress-in-a-mouse-model
#14
Bang Shen, Yuan Yuan, Jianxi Cheng, Ming Pan, Ningbo Xia, Weichao Zhang, Yifan Wang, Yanqin Zhou, Junlong Zhao
Toxoplasma gondii is an obligate intracellular parasite infecting 25% of the world population and enormous number of animals. It can exist in two forms in intermediate hosts: the fast replicating tachyzoites responsible for acute infection and the slowly replicating bradyzoites responsible for life-long chronic infection. The interconversion between tachyzoites and bradyzoites plays critical roles in the transmission and pathogenesis of T. gondii. However, the molecular mechanisms that govern the interconversion are largely unknown...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27828280/enhanced-absorptance-of-the-assembly-structure-incorporating-germanium-nanorods-and-two-dimensional-silicon-gratings-for-photovoltaics
#15
Zhihao Jia, Qiang Cheng, Jinlin Song, Yifan Zhou, Yang Liu
This paper proposes an assembly structure incorporating two-dimensional silicon gratings and germanium nanorods applied to photovoltaic absorbers. The absorptance of the assembly structure is numerically investigated using the finite-difference time-domain method. The results demonstrate that such a structure can greatly improve the absorptance and conversion efficiency compared to the gratings or nanowires in the 300-1100 nm wavelength region. The average spectral absorptance of such a structure reaches up to 0...
November 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27669148/automated-structure-refinement-of-macromolecular-assemblies-from-cryo-em-maps-using-rosetta
#16
Ray Yu-Ruei Wang, Yifan Song, Benjamin A Barad, Yifan Cheng, James S Fraser, Frank DiMaio
Cryo-EM has revealed the structures of many challenging yet exciting macromolecular assemblies at near-atomic resolution (3-4.5Å), providing biological phenomena with molecular descriptions. However, at these resolutions, accurately positioning individual atoms remains challenging and error-prone. Manually refining thousands of amino acids - typical in a macromolecular assembly - is tedious and time-consuming. We present an automated method that can improve the atomic details in models that are manually built in near-atomic-resolution cryo-EM maps...
September 26, 2016: ELife
https://www.readbyqxmd.com/read/27633676/hsp70-gene-expansions-in-the-scallop-patinopecten-yessoensis-and-their-expression-regulation-after-exposure-to-the-toxic-dinoflagellate-alexandrium-catenella
#17
Jie Cheng, Xiaogang Xun, Yifan Kong, Shuyue Wang, Zhihui Yang, Yajuan Li, Dexu Kong, Shi Wang, Lingling Zhang, Xiaoli Hu, Zhenmin Bao
Heat shock protein 70 (Hsp70s) family members are present in virtually all living organisms and perform a fundamental role against different types of environmental stressors and pathogenic organisms. Marine bivalves live in highly dynamic environments and may accumulate paralytic shellfish toxins (PSTs), a class of well-known neurotoxins closely associated with harmful algal blooms (HABs). Here, we provide a systematic analysis of Hsp70 genes (PyHsp70s) in the genome of Yesso scallop (Patinopecten yessoensis), an important aquaculture species in China, through in silico analysis using transcriptome and genome databases...
November 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27602095/estrogen-therapy-increases-bdnf-expression-and-improves-post-stroke-depression-in-ovariectomy-treated-rats
#18
Qiaoer Su, Yifan Cheng, Kunlin Jin, Jianhua Cheng, Yuanshao Lin, Zhenzhen Lin, Liuqing Wang, Bei Shao
The present study investigated the effect of exogenous estrogen on post-stroke depression. Rats were exposed to chronic mild stress following middle cerebral artery occlusion. The occurrence of post-stroke depression was evaluated according to the changes in preference for sucrose and performance in a forced swimming test. Estrogen therapy significantly improved these neurological symptoms, indicating that estrogen is effective in treating post-stroke depression. Increased brain-derived neurotrophic factor (BDNF) expression was reported in the hippocampus of rats that had been treated with estrogen for two weeks, suggesting that BDNF expression may be an important contributor to the improvement of post-stroke depression that is observed following estrogen therapy...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27583770/discovery-of-6-fluoro-5-r-3-s-8-fluoro-1-methyl-2-4-dioxo-1-2-dihydroquinazolin-3-4h-yl-2-methylphenyl-2-s-2-hydroxypropan-2-yl-2-3-4-9-tetrahydro-1h-carbazole-8-carboxamide-bms-986142-a-reversible-inhibitor-of-bruton-s-tyrosine-kinase-btk-conformationally
#19
Scott H Watterson, George V De Lucca, Qing Shi, Charles M Langevine, Qingjie Liu, Douglas G Batt, Myra Beaudoin Bertrand, Hua Gong, Jun Dai, Shiuhang Yip, Peng Li, Dawn Sun, Dauh-Rurng Wu, Chunlei Wang, Yingru Zhang, Sarah C Traeger, Mark A Pattoli, Stacey Skala, Lihong Cheng, Mary T Obermeier, Rodney Vickery, Lorell N Discenza, Celia J D'Arienzo, Yifan Zhang, Elizabeth Heimrich, Kathleen M Gillooly, Tracy L Taylor, Claudine Pulicicchio, Kim W McIntyre, Michael A Galella, Andy J Tebben, Jodi K Muckelbauer, ChiehYing Chang, Richard Rampulla, Arvind Mathur, Luisa Salter-Cid, Joel C Barrish, Percy H Carter, Aberra Fura, James R Burke, Joseph A Tino
Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε receptor signaling in mast cells and basophils, all of which have been implicated in the pathophysiology of autoimmune disease. As a result, inhibition of BTK is anticipated to provide an effective strategy for the clinical treatment of autoimmune diseases such as lupus and rheumatoid arthritis...
October 13, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27556998/long-term-phase-locking-technique-for-locking-the-repetition-rate-of-an-optical-frequency-comb-laser-with-1-67%C3%A2-%C3%A3-%C3%A2-10-sup-19-sup-precision
#20
Cheng Ci, Xuesong Zhang, Xinran Li, Xing Chen, Yifan Cui, Yingxin Zhao, Bo Liu, Hong Wu
An ultrahigh stable phase-locked loop system for synchronization of an optical frequency comb to a hydrogen maser has been proposed and experimentally demonstrated. A mathematical model has been set up to investigate the feasibility and steady state of the phase-locking system. The fractional frequency instability is evaluated by measuring the mixed-phase signal of an improved experimental system. Experimental results show that the fractional frequency instability of the phase-locked loop system lies from 8...
August 20, 2016: Applied Optics
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