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Yifan Cheng

Ying-Fang Guo, Nian-Nian Xu, Weijing Sun, Yifan Zhao, Cheng-Ye Li, Meng-Yao Guo
Mastitis is a serious and prevalent disease caused by infection by pathogens such as Staphylococcus aureus. We evaluated the anti-inflammatory effects and mechanism of luteolin, a natural flavonoid with a wide range of pharmacological activities, in a mouse model of S. aureus mastitis. We also treated cultured mouse mammary epithelial cells (mMECs) with S. aureus and luteolin. Histopathological changes were examined by H&E staining and the levels of inflammatory cytokine proteins were analyzed using ELISAs...
March 10, 2017: Oncotarget
Jing Lv, Yu Pan, Huijun Ju, Jinxin Zhou, Dengfeng Cheng, Hongcheng Shi, Yifan Zhang
Sleeping Beauty (SB) transposon is an attractive tool in stable transgene integration both in vitro and in vivo; and we introduced SB transposon into recombinant sodium-iodide symporter baculovirus system (Bac-NIS system) to facilitate long-term expression of recombinant sodium-iodide symporter. In our study, two hybrid baculovirus systems (Bac-eGFP-SB-NeoR and Bac-NIS-SB-NeoR) were successfully constructed and used to infect U87 glioma cells. After G418 selection screening, the Bac-eGFP-SB-NeoR-U87 cells remained eGFP positive, at the 18(th) and 196(th) day post transfection (96...
March 6, 2017: Scientific Reports
Shawn Q Zheng, Eugene Palovcak, Jean-Paul Armache, Kliment A Verba, Yifan Cheng, David A Agard
No abstract text is available yet for this article.
April 2017: Nature Methods
Cheng Peng, Yifan Zhang, Yibin Zhang, Zichao Zhou, Yanke Che, Jincai Zhao
Novel stimuli-responsive microscale materials capable of undergoing diverse out-of-plane helical motions (e.g., bending, twisting and coiling) when exposed to electron irradiation are reported. The macroscopic morphological changes of microribbons induced by electrons arise from the combination of diagonal in-plane, non-bonded distortion relative to the long axis of the microribbon and vertical non-bonded distortion.
February 13, 2017: Chemical Communications: Chem Comm
Wang Dong, Huifang Lv, Yifan Wang, Xiaomeng Li, Cheng Li, Lu Wang, Chengbao Wang, Kangkang Guo, Yanming Zhang
Infection with classical swine fever virus (CSFV) results in highly significant economic losses; this infection is characterized by being highly contagious and accompanied by hyperthermia and systemic bleeding. Oxidative stress (OS) plays a critical role in the pathological process of viral infection. The function of the nonstructural protein 5A (NS5A) in the pathogenesis of CSFV has not been completely understood. Here, OS and the inflammatory response were studied with NS5A and substitution mutants in swine testicular (ST) cells...
January 13, 2017: Research in Veterinary Science
Xumin Ou, Sai Mao, Yifan Jiang, Shengyong Zhang, Chen Ke, Guangpeng Ma, Anchun Cheng, Mingshu Wang, Dekang Zhu, Shun Chen, Renyong Jia, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu, Xiaoyue Chen
Hepatitis A virus is one of five types of hepatotropic viruses that cause human liver disease. A similar liver disease is also identified in ducks caused by Duck Hepatitis A virus (DHAV). Notably, many types of hepatotropic viruses can be detected in urine. However, how those viruses enter into the urine is largely unexplored. To elucidate the potential mechanism, we used the avian hepatotropic virus to investigate replication strategies and immune responses in kidney until 280 days after infection. Immunohistochemistry and qPCR were used to detect viral distribution and copies in the kidney...
January 31, 2017: Oncotarget
Shi Chen, Jun Liu, Yifan Zhao, Long Zhu, Andong Wang, Shuhui Li, Jing Du, Cheng Du, Qi Mo, Jian Wang
We present a full-duplex bidirectional data transmission link using twisted lights multiplexing over 1.1-km orbital angular momentum (OAM) fiber. OAM+1 and OAM-1 modes carrying 20-Gbit/s quadrature phase-shift keying (QPSK) signals are employed in the downlink and uplink transmission experiments. The observed mode crosstalks are less than -15.2 dB, and the full-duplex crosstalks are less than -12.7 dB. The measured full-duplex optical signal-to-noise ratio (OSNR) penalties at a bit-error rate (BER) of 2 × 10(-3) are ~2...
November 30, 2016: Scientific Reports
Bang Shen, Yuan Yuan, Jianxi Cheng, Ming Pan, Ningbo Xia, Weichao Zhang, Yifan Wang, Yanqin Zhou, Junlong Zhao
Toxoplasma gondii is an obligate intracellular parasite infecting 25% of the world population and enormous number of animals. It can exist in two forms in intermediate hosts: the fast replicating tachyzoites responsible for acute infection and the slowly replicating bradyzoites responsible for life-long chronic infection. The interconversion between tachyzoites and bradyzoites plays critical roles in the transmission and pathogenesis of T. gondii. However, the molecular mechanisms that govern the interconversion are largely unknown...
December 27, 2016: Oncotarget
Zhihao Jia, Qiang Cheng, Jinlin Song, Yifan Zhou, Yang Liu
This paper proposes an assembly structure incorporating two-dimensional silicon gratings and germanium nanorods applied to photovoltaic absorbers. The absorptance of the assembly structure is numerically investigated using the finite-difference time-domain method. The results demonstrate that such a structure can greatly improve the absorptance and conversion efficiency compared to the gratings or nanowires in the 300-1100 nm wavelength region. The average spectral absorptance of such a structure reaches up to 0...
November 1, 2016: Applied Optics
Ray Yu-Ruei Wang, Yifan Song, Benjamin A Barad, Yifan Cheng, James S Fraser, Frank DiMaio
Cryo-EM has revealed the structures of many challenging yet exciting macromolecular assemblies at near-atomic resolution (3-4.5Å), providing biological phenomena with molecular descriptions. However, at these resolutions, accurately positioning individual atoms remains challenging and error-prone. Manually refining thousands of amino acids - typical in a macromolecular assembly - is tedious and time-consuming. We present an automated method that can improve the atomic details in models that are manually built in near-atomic-resolution cryo-EM maps...
September 26, 2016: ELife
Jie Cheng, Xiaogang Xun, Yifan Kong, Shuyue Wang, Zhihui Yang, Yajuan Li, Dexu Kong, Shi Wang, Lingling Zhang, Xiaoli Hu, Zhenmin Bao
Heat shock protein 70 (Hsp70s) family members are present in virtually all living organisms and perform a fundamental role against different types of environmental stressors and pathogenic organisms. Marine bivalves live in highly dynamic environments and may accumulate paralytic shellfish toxins (PSTs), a class of well-known neurotoxins closely associated with harmful algal blooms (HABs). Here, we provide a systematic analysis of Hsp70 genes (PyHsp70s) in the genome of Yesso scallop (Patinopecten yessoensis), an important aquaculture species in China, through in silico analysis using transcriptome and genome databases...
November 2016: Fish & Shellfish Immunology
Qiaoer Su, Yifan Cheng, Kunlin Jin, Jianhua Cheng, Yuanshao Lin, Zhenzhen Lin, Liuqing Wang, Bei Shao
The present study investigated the effect of exogenous estrogen on post-stroke depression. Rats were exposed to chronic mild stress following middle cerebral artery occlusion. The occurrence of post-stroke depression was evaluated according to the changes in preference for sucrose and performance in a forced swimming test. Estrogen therapy significantly improved these neurological symptoms, indicating that estrogen is effective in treating post-stroke depression. Increased brain-derived neurotrophic factor (BDNF) expression was reported in the hippocampus of rats that had been treated with estrogen for two weeks, suggesting that BDNF expression may be an important contributor to the improvement of post-stroke depression that is observed following estrogen therapy...
September 2016: Experimental and Therapeutic Medicine
Scott H Watterson, George V De Lucca, Qing Shi, Charles M Langevine, Qingjie Liu, Douglas G Batt, Myra Beaudoin Bertrand, Hua Gong, Jun Dai, Shiuhang Yip, Peng Li, Dawn Sun, Dauh-Rurng Wu, Chunlei Wang, Yingru Zhang, Sarah C Traeger, Mark A Pattoli, Stacey Skala, Lihong Cheng, Mary T Obermeier, Rodney Vickery, Lorell N Discenza, Celia J D'Arienzo, Yifan Zhang, Elizabeth Heimrich, Kathleen M Gillooly, Tracy L Taylor, Claudine Pulicicchio, Kim W McIntyre, Michael A Galella, Andy J Tebben, Jodi K Muckelbauer, ChiehYing Chang, Richard Rampulla, Arvind Mathur, Luisa Salter-Cid, Joel C Barrish, Percy H Carter, Aberra Fura, James R Burke, Joseph A Tino
Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε receptor signaling in mast cells and basophils, all of which have been implicated in the pathophysiology of autoimmune disease. As a result, inhibition of BTK is anticipated to provide an effective strategy for the clinical treatment of autoimmune diseases such as lupus and rheumatoid arthritis...
October 13, 2016: Journal of Medicinal Chemistry
Cheng Ci, Xuesong Zhang, Xinran Li, Xing Chen, Yifan Cui, Yingxin Zhao, Bo Liu, Hong Wu
An ultrahigh stable phase-locked loop system for synchronization of an optical frequency comb to a hydrogen maser has been proposed and experimentally demonstrated. A mathematical model has been set up to investigate the feasibility and steady state of the phase-locking system. The fractional frequency instability is evaluated by measuring the mixed-phase signal of an improved experimental system. Experimental results show that the fractional frequency instability of the phase-locked loop system lies from 8...
August 20, 2016: Applied Optics
Yifan Zhang, Cheng Peng, Bin Cui, Zhengfei Wang, Xibin Pang, Renmin Ma, Feng Liu, Yanke Che, Jincai Zhao
Novel direction-controlled movements of microribbons self-assembled from perylene diimide molecules are reported on various hydrophobic surfaces under scanning laser irradiation. A "dynamic exciton charge model" is developed to elucidate the underlying mechanism. The findings provide an innovative strategy for the design of microscale systems capable of continuous and directional movement driven by light.
October 2016: Advanced Materials
Yingjie Fu, Qishuai Feng, Yifan Chen, Yajing Shen, Qihang Su, Yinglei Zhang, Xiang Zhou, Yu Cheng
Drug attachment is important in drug delivery for cancer chemotherapy. The elucidation of the release mechanism and biological behavior of a drug is essential for the design of delivery systems. Here, we used a hydrazone bond or an amide bond to attach an anticancer drug, doxorubicin (Dox), to gold nanoparticles (GNPs) and compared the effects of the chemical bond on the anticancer activities of the resulting Dox-GNPs. The drug release efficiency, cytotoxicity, subcellular distribution, and cell apoptosis of hydrazone-linked HDox-GNPs and amide-linked SDox-GNPs were evaluated in several cancer cells...
September 6, 2016: Molecular Pharmaceutics
Cheng Peng, Yibin Zhang, Yifan Zhang, Yanyong Hu, Yanke Che, Jincai Zhao
Highly fluorescent bilayer-walled and monolayer-walled nanotubes are assembled from elaborately designed asymmetric perylene diimide (PDI) molecules. The diameter of bilayer-walled nanotubes increases with the size of the branched substituents at the meta-position of the phenyl moiety of PDI molecules, whereas that of monolayer-walled nanotubes remains unchanged regardless of the size of branched substituents.
August 2016: Small
Yuan Gao, Erhu Cao, David Julius, Yifan Cheng
When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrate the power of combining electron cryo-microscopy with lipid nanodisc technology to ascertain the structure of the rat TRPV1 ion channel in a native bilayer environment. Using this approach, we determined the locations of annular and regulatory lipids and showed that specific phospholipid interactions enhance binding of a spider toxin to TRPV1 through formation of a tripartite complex...
June 16, 2016: Nature
Yibin Zhang, Yingxuan Zheng, Wei Xiong, Cheng Peng, Yifan Zhang, Ran Duan, Yanke Che, Jincai Zhao
Kinetic control over the assembly pathways towards novel metastable functional materials or far-from-equilibrium systems has been much less studied compared to the thermodynamic equilibrium self-assembly. Herein, we report the distinct morphological transformation between nanocoils and nanoribbons in the self-assembly of unsymmetric perylene diimide (PDI) molecules. We demonstrate that the morphological transformation of the kinetically trapped assemblies into the thermodynamically stable forms proceeds via two distinct mechanisms, i...
2016: Scientific Reports
Jin Liu, Lingling Bian, Li Ji, Yang Chen, Heng Chen, Yong Gu, Bingqin Ma, Wei Gu, Xinyu Xu, Yun Shi, Jian Wang, Dalong Zhu, Zilin Sun, Jianhua Ma, Hui Jin, Xing Shi, Heng Miao, Bing Xin, Yan Zhu, Zhenwen Zhang, Ruifang Bu, Lan Xu, Guangde Shi, Wei Tang, Wei Li, Dongmei Zhou, Jun Liang, Xingbo Cheng, Bimin Shi, Jixiang Dong, Ji Hu, Chen Fang, Shao Zhong, Weinan Yu, Weiping Lu, Chenguang Wu, Li Qian, Jiancheng Yu, Jialin Gao, Xiaoqiang Fei, Qingqing Zhang, Xueqin Wang, Shiwei Cui, Jinluo Cheng, Ning Xu, Guofeng Wang, Guoqing Han, Chunrong Xu, Yun Xie, Minmin An, Wei Zhang, Zhixiao Wang, Yun Cai, Qi Fu, Yu Fu, Shuai Zheng, Fan Yang, Qingfang Hu, Hao Dai, Yu Jin, Zheng Zhang, Kuanfeng Xu, Yifan Li, Jie Shen, Hongwen Zhou, Wei He, Xuqin Zheng, Xiao Han, Liping Yu, Jinxiong She, Mei Zhang, Tao Yang
Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study...
September 2016: Science China. Life Sciences
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