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Yifan Cheng

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https://www.readbyqxmd.com/read/27901082/full-duplex-bidirectional-data-transmission-link-using-twisted-lights-multiplexing-over-1-1-km-orbital-angular-momentum-fiber
#1
Shi Chen, Jun Liu, Yifan Zhao, Long Zhu, Andong Wang, Shuhui Li, Jing Du, Cheng Du, Qi Mo, Jian Wang
We present a full-duplex bidirectional data transmission link using twisted lights multiplexing over 1.1-km orbital angular momentum (OAM) fiber. OAM+1 and OAM-1 modes carrying 20-Gbit/s quadrature phase-shift keying (QPSK) signals are employed in the downlink and uplink transmission experiments. The observed mode crosstalks are less than -15.2 dB, and the full-duplex crosstalks are less than -12.7 dB. The measured full-duplex optical signal-to-noise ratio (OSNR) penalties at a bit-error rate (BER) of 2 × 10(-3) are ~2...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895319/activation-of-chronic-toxoplasmosis-by-transportation-stress-in-a-mouse-model
#2
Bang Shen, Yuan Yuan, Jianxi Cheng, Ming Pan, Ningbo Xia, Weichao Zhang, Yifan Wang, Yanqin Zhou, Junlong Zhao
Toxoplasma gondii is an obligate intracellular parasite infecting 25% of the world population and enormous number of animals. It can exist in two forms in intermediate hosts: the fast replicating tachyzoites responsible for acute infection and the slowly replicating bradyzoites responsible for life-long chronic infection. The interconversion between tachyzoites and bradyzoites plays critical roles in the transmission and pathogenesis of T. gondii. However, the molecular mechanisms that govern the interconversion are largely unknown...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27828280/enhanced-absorptance-of-the-assembly-structure-incorporating-germanium-nanorods-and-two-dimensional-silicon-gratings-for-photovoltaics
#3
Zhihao Jia, Qiang Cheng, Jinlin Song, Yifan Zhou, Yang Liu
This paper proposes an assembly structure incorporating two-dimensional silicon gratings and germanium nanorods applied to photovoltaic absorbers. The absorptance of the assembly structure is numerically investigated using the finite-difference time-domain method. The results demonstrate that such a structure can greatly improve the absorptance and conversion efficiency compared to the gratings or nanowires in the 300-1100 nm wavelength region. The average spectral absorptance of such a structure reaches up to 0...
November 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27669148/automated-structure-refinement-of-macromolecular-assemblies-from-cryo-em-maps-using-rosetta
#4
Ray Yu-Ruei Wang, Yifan Song, Benjamin A Barad, Yifan Cheng, James S Fraser, Frank DiMaio
Cryo-EM has revealed the structures of many challenging yet exciting macromolecular assemblies at near-atomic resolution (3-4.5Å), providing biological phenomena with molecular descriptions. However, at these resolutions, accurately positioning individual atoms remains challenging and error-prone. Manually refining thousands of amino acids - typical in a macromolecular assembly - is tedious and time-consuming. We present an automated method that can improve the atomic details in models that are manually built in near-atomic-resolution cryo-EM maps...
September 26, 2016: ELife
https://www.readbyqxmd.com/read/27633676/hsp70-gene-expansions-in-the-scallop-patinopecten-yessoensis-and-their-expression-regulation-after-exposure-to-the-toxic-dinoflagellate-alexandrium-catenella
#5
Jie Cheng, Xiaogang Xun, Yifan Kong, Shuyue Wang, Zhihui Yang, Yajuan Li, Dexu Kong, Shi Wang, Lingling Zhang, Xiaoli Hu, Zhenmin Bao
Heat shock protein 70 (Hsp70s) family members are present in virtually all living organisms and perform a fundamental role against different types of environmental stressors and pathogenic organisms. Marine bivalves live in highly dynamic environments and may accumulate paralytic shellfish toxins (PSTs), a class of well-known neurotoxins closely associated with harmful algal blooms (HABs). Here, we provide a systematic analysis of Hsp70 genes (PyHsp70s) in the genome of Yesso scallop (Patinopecten yessoensis), an important aquaculture species in China, through in silico analysis using transcriptome and genome databases...
September 12, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27602095/estrogen-therapy-increases-bdnf-expression-and-improves-post-stroke-depression-in-ovariectomy-treated-rats
#6
Qiaoer Su, Yifan Cheng, Kunlin Jin, Jianhua Cheng, Yuanshao Lin, Zhenzhen Lin, Liuqing Wang, Bei Shao
The present study investigated the effect of exogenous estrogen on post-stroke depression. Rats were exposed to chronic mild stress following middle cerebral artery occlusion. The occurrence of post-stroke depression was evaluated according to the changes in preference for sucrose and performance in a forced swimming test. Estrogen therapy significantly improved these neurological symptoms, indicating that estrogen is effective in treating post-stroke depression. Increased brain-derived neurotrophic factor (BDNF) expression was reported in the hippocampus of rats that had been treated with estrogen for two weeks, suggesting that BDNF expression may be an important contributor to the improvement of post-stroke depression that is observed following estrogen therapy...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27583770/discovery-of-6-fluoro-5-r-3-s-8-fluoro-1-methyl-2-4-dioxo-1-2-dihydroquinazolin-3-4h-yl-2-methylphenyl-2-s-2-hydroxypropan-2-yl-2-3-4-9-tetrahydro-1h-carbazole-8-carboxamide-bms-986142-a-reversible-inhibitor-of-bruton-s-tyrosine-kinase-btk-conformationally
#7
Scott H Watterson, George V De Lucca, Qing Shi, Charles M Langevine, Qingjie Liu, Douglas G Batt, Myra Beaudoin Bertrand, Hua Gong, Jun Dai, Shiuhang Yip, Peng Li, Dawn Sun, Dauh-Rurng Wu, Chunlei Wang, Yingru Zhang, Sarah C Traeger, Mark A Pattoli, Stacey Skala, Lihong Cheng, Mary T Obermeier, Rodney Vickery, Lorell N Discenza, Celia J D'Arienzo, Yifan Zhang, Elizabeth Heimrich, Kathleen M Gillooly, Tracy L Taylor, Claudine Pulicicchio, Kim W McIntyre, Michael A Galella, Andy J Tebben, Jodi K Muckelbauer, ChiehYing Chang, Richard Rampulla, Arvind Mathur, Luisa Salter-Cid, Joel C Barrish, Percy H Carter, Aberra Fura, James R Burke, Joseph A Tino
Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε receptor signaling in mast cells and basophils, all of which have been implicated in the pathophysiology of autoimmune disease. As a result, inhibition of BTK is anticipated to provide an effective strategy for the clinical treatment of autoimmune diseases such as lupus and rheumatoid arthritis...
October 13, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27556998/long-term-phase-locking-technique-for-locking-the-repetition-rate-of-an-optical-frequency-comb-laser-with-1-67%C3%A2-%C3%A3-%C3%A2-10-sup-19-sup-precision
#8
Cheng Ci, Xuesong Zhang, Xinran Li, Xing Chen, Yifan Cui, Yingxin Zhao, Bo Liu, Hong Wu
An ultrahigh stable phase-locked loop system for synchronization of an optical frequency comb to a hydrogen maser has been proposed and experimentally demonstrated. A mathematical model has been set up to investigate the feasibility and steady state of the phase-locking system. The fractional frequency instability is evaluated by measuring the mixed-phase signal of an improved experimental system. Experimental results show that the fractional frequency instability of the phase-locked loop system lies from 8...
August 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27523915/direction-controlled-light-driven-movement-of-microribbons
#9
Yifan Zhang, Cheng Peng, Bin Cui, Zhengfei Wang, Xibin Pang, Renmin Ma, Feng Liu, Yanke Che, Jincai Zhao
Novel direction-controlled movements of microribbons self-assembled from perylene diimide molecules are reported on various hydrophobic surfaces under scanning laser irradiation. A "dynamic exciton charge model" is developed to elucidate the underlying mechanism. The findings provide an innovative strategy for the design of microscale systems capable of continuous and directional movement driven by light.
October 2016: Advanced Materials
https://www.readbyqxmd.com/read/27518201/comparison-of-two-approaches-for-the-attachment-of-a-drug-to-gold-nanoparticles-and-their-anticancer-activities
#10
Yingjie Fu, Qishuai Feng, Yifan Chen, Yajing Shen, Qihang Su, Yinglei Zhang, Xiang Zhou, Yu Cheng
Drug attachment is important in drug delivery for cancer chemotherapy. The elucidation of the release mechanism and biological behavior of a drug is essential for the design of delivery systems. Here, we used a hydrazone bond or an amide bond to attach an anticancer drug, doxorubicin (Dox), to gold nanoparticles (GNPs) and compared the effects of the chemical bond on the anticancer activities of the resulting Dox-GNPs. The drug release efficiency, cytotoxicity, subcellular distribution, and cell apoptosis of hydrazone-linked HDox-GNPs and amide-linked SDox-GNPs were evaluated in several cancer cells...
September 6, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27375155/highly-fluorescent-nanotubes-with-tunable-diameter-and-wall-thickness-self-assembled-from-asymmetric-perylene-diimides
#11
Cheng Peng, Yibin Zhang, Yifan Zhang, Yanyong Hu, Yanke Che, Jincai Zhao
Highly fluorescent bilayer-walled and monolayer-walled nanotubes are assembled from elaborately designed asymmetric perylene diimide (PDI) molecules. The diameter of bilayer-walled nanotubes increases with the size of the branched substituents at the meta-position of the phenyl moiety of PDI molecules, whereas that of monolayer-walled nanotubes remains unchanged regardless of the size of branched substituents.
August 2016: Small
https://www.readbyqxmd.com/read/27281200/trpv1-structures-in-nanodiscs-reveal-mechanisms-of-ligand-and-lipid-action
#12
Yuan Gao, Erhu Cao, David Julius, Yifan Cheng
When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrate the power of combining electron cryo-microscopy with lipid nanodisc technology to ascertain the structure of the rat TRPV1 ion channel in a native bilayer environment. Using this approach, we determined the locations of annular and regulatory lipids and showed that specific phospholipid interactions enhance binding of a spider toxin to TRPV1 through formation of a tripartite complex...
May 18, 2016: Nature
https://www.readbyqxmd.com/read/27251755/morphological-transformation-between-nanocoils-and-nanoribbons-via-defragmentation-structural-rearrangement-or-fragmentation-recombination-mechanism
#13
Yibin Zhang, Yingxuan Zheng, Wei Xiong, Cheng Peng, Yifan Zhang, Ran Duan, Yanke Che, Jincai Zhao
Kinetic control over the assembly pathways towards novel metastable functional materials or far-from-equilibrium systems has been much less studied compared to the thermodynamic equilibrium self-assembly. Herein, we report the distinct morphological transformation between nanocoils and nanoribbons in the self-assembly of unsymmetric perylene diimide (PDI) molecules. We demonstrate that the morphological transformation of the kinetically trapped assemblies into the thermodynamically stable forms proceeds via two distinct mechanisms, i...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27225179/the-heterogeneity-of-islet-autoantibodies-and-the-progression-of-islet-failure-in-type-1-diabetic-patients
#14
Jin Liu, Lingling Bian, Li Ji, Yang Chen, Heng Chen, Yong Gu, Bingqin Ma, Wei Gu, Xinyu Xu, Yun Shi, Jian Wang, Dalong Zhu, Zilin Sun, Jianhua Ma, Hui Jin, Xing Shi, Heng Miao, Bing Xin, Yan Zhu, Zhenwen Zhang, Ruifang Bu, Lan Xu, Guangde Shi, Wei Tang, Wei Li, Dongmei Zhou, Jun Liang, Xingbo Cheng, Bimin Shi, Jixiang Dong, Ji Hu, Chen Fang, Shao Zhong, Weinan Yu, Weiping Lu, Chenguang Wu, Li Qian, Jiancheng Yu, Jialin Gao, Xiaoqiang Fei, Qingqing Zhang, Xueqin Wang, Shiwei Cui, Jinluo Cheng, Ning Xu, Guofeng Wang, Guoqing Han, Chunrong Xu, Yun Xie, Minmin An, Wei Zhang, Zhixiao Wang, Yun Cai, Qi Fu, Yu Fu, Shuai Zheng, Fan Yang, Qingfang Hu, Hao Dai, Yu Jin, Zheng Zhang, Kuanfeng Xu, Yifan Li, Jie Shen, Hongwen Zhou, Wei He, Xuqin Zheng, Xiao Han, Liping Yu, Jinxiong She, Mei Zhang, Tao Yang
Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study...
September 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27148819/gallic-acid-l-leucine-gal-conjugate-enhances-macrophage-phagocytosis-via-inducing-leukotriene-b4-12-hydroxydehydrogenase-ltb4dh-expression
#15
Yuanyuan Cheng, Hung-Fat Tse, Xuechen Li, Yifan Han, Jianhui Rong
Timely clearance of apoptotic cells is an important step in the resolution of ongoing inflammation and the restoration of tissue integrity and function after acute myocardial infarction. Natural products gallic acid and l-leucine are well-documented for anti-inflammatory and anabolic effects. We synthesized gallic acid-l-leucine (GAL) conjugate via direct coupling gallic acid and l-leucine. The aim of the present study was to investigate the effect of GAL conjugate on the phagocytotic activity of macrophages...
June 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27080554/insulin-resistance-is-associated-with-altered-amino-acid-metabolism-and-adipose-tissue-dysfunction-in-normoglycemic-women
#16
Petri Wiklund, Xiaobo Zhang, Satu Pekkala, Reija Autio, Lingjia Kong, Yifan Yang, Sirkka Keinänen-Kiukaanniemi, Markku Alen, Sulin Cheng
Insulin resistance is associated adiposity, but the mechanisms are not fully understood. In this study, we aimed to identify early metabolic alterations associated with insulin resistance in normoglycemic women with varying degree of adiposity. One-hundred and ten young and middle-aged women were divided into low and high IR groups based on their median HOMA-IR (0.9 ± 0.4 vs. 2.8 ± 1.2). Body composition was assessed using DXA, skeletal muscle and liver fat by proton magnetic resonance spectroscopy, serum metabolites by nuclear magnetic resonance spectroscopy and adipose tissue and skeletal muscle gene expression by microarrays...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27034732/plant-natural-product-formononetin-protects-rat-cardiomyocyte-h9c2-cells-against-oxygen-glucose-deprivation-and-reoxygenation-via-inhibiting-ros-formation-and-promoting-gsk-3%C3%AE-phosphorylation
#17
Yuanyuan Cheng, Zhengyuan Xia, Yifan Han, Jianhui Rong
The opening of mitochondrial permeability transition pore (mPTP) is a major cause of cell death in ischemia reperfusion injury. Based on our pilot experiments, plant natural product formononetin enhanced the survival of rat cardiomyocyte H9c2 cells during oxygen glucose deprivation (OGD) and reoxygenation. For mechanistic studies, we focused on two major cellular factors, namely, reactive oxygen species (ROS) and glycogen synthase kinase 3β (GSK-3β), in the regulation of mPTP opening. We found that formononetin suppressed the formation of ROS and superoxide in a concentration-dependent manner...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26954181/effects-of-three-feeding-systems-on-production-performance-rumen-fermentation-and-rumen-digesta-particle-structure-of-beef-cattle
#18
Y F Liu, F F Sun, F C Wan, H B Zhao, X M Liu, W You, H J Cheng, G F Liu, X W Tan, E L Song
The effects of three different feeding systems on beef cattle production performance, rumen fermentation, and rumen digesta particle structure were investigated by using 18 Limousin (steers) with a similar body weight (575±10 kg) in a 80-d experiment. The animals were equally and randomly divided into three treatment groups, namely, total mixed ration group (cattle fed TMR), SI1 group (cattle fed concentrate firstly then roughage), and SI2 group (cattle fed roughage firstly then concentrate). The results showed that the average daily gain was significantly higher in cattle receiving TMR than in those receiving SI1 and SI2 (p<0...
May 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/26954111/substitution-of-wheat-for-corn-in-beef-cattle-diets-digestibility-digestive-enzyme-activities-serum-metabolite-contents-and-ruminal-fermentation
#19
Y F Liu, H B Zhao, X M Liu, W You, H J Cheng, F C Wan, G F Liu, X W Tan, E L Song, X L Zhang
The objective of this study was to evaluate the effect of diets containing different amounts of wheat, as a partial or whole substitute for corn, on digestibility, digestive enzyme activities, serum metabolite contents and ruminal fermentation in beef cattle. Four Limousin×LuXi crossbred cattle with a body weight (400±10 kg), fitted with permanent ruminal, proximal duodenal and terminal ileal cannulas, were used in a 4×4 Latin square design with four treatments: Control (100% corn), 33% wheat (33% substitution for corn), 67% wheat (67% substitution for corn), and 100% wheat (100% substitution for corn) on a dry matter basis...
October 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/26950744/a-saposin-lipoprotein-nanoparticle-system-for-membrane-proteins
#20
Jens Frauenfeld, Robin Löving, Jean-Paul Armache, Andreas F-P Sonnen, Fatma Guettou, Per Moberg, Lin Zhu, Caroline Jegerschöld, Ali Flayhan, John A G Briggs, Henrik Garoff, Christian Löw, Yifan Cheng, Pär Nordlund
A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with structural and biophysical studies. Here we present a saposin-lipoprotein nanoparticle system, Salipro, which allows for the reconstitution of membrane proteins in a lipid environment that is stabilized by a scaffold of saposin proteins. We demonstrate the applicability of the method on two purified membrane protein complexes as well as by the direct solubilization and nanoparticle incorporation of a viral membrane protein complex from the virus membrane...
April 2016: Nature Methods
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