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the contribution of citotoxic

Lilian Dos Anjos Oliveira Ferreira, Mariana Maciel de Oliveira, Flávia Lais Faleiro, Débora Botura Scariot, Joana Schuelter Boeing, Jesuí Vergílio Visentainer, Mariza Barion Romagnolo, Celso Vataru Nakamura, Maria da Conceição Torrado Truiti
The effects on the viability of promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and citotoxicity in J774.A1 macrophages of ethanolic extract, fractions and isolated compounds that were obtained from the leaves of Nectandra cuspidata were determined. The total phenolics content (TP) and antioxidant activity were assessed using different assays. The ethyl acetate fraction (EAF) had the best antiproliferative activity (amastigote IC50: 4.42 ± 0.60 μg/mL, promastigote IC50: 33.33 ± 0...
September 19, 2017: Natural Product Research
Mariana Novo Belchor, Henrique Hessel Gaeta, Caroline Fabri Bittencourt Rodrigues, Caroline Ramos da Cruz Costa, Daniela de Oliveira Toyama, Luiz Felipe Domingues Passero, Marcia Dalastra Laurenti, Marcos Hikari Toyama
Rhamnetin (Rhm), 3-O-methylquercetin (3MQ), and Rhamnazin (Rhz) are methylated derivatives of quercetin commonly found in fruits and vegetables that possess antioxidant and anti-inflammatory properties. Phospholipase A2 (PLA2) displays several important roles during acute inflammation; therefore, this study aimed at investigating new compounds able to inhibit this enzyme, besides evaluating creatine kinase (CK) levels and citotoxicity. Methylated quercetins were compared with quercetin (Q) and were incubated with secretory PLA2 (sPLA2) from Bothrops jararacussu to determine their inhibitory activity...
August 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
C de Oliveira Mendes-Aguiar, R Vieira-Gonçalves, L H Guimarães, M P de Oliveira-Neto, E M Carvalho, A M Da-Cruz
A high number of Leishmania-responder T cells is found in cutaneous leishmaniasis lesions, suggesting that important immunological events occur at the site of infection. Although activated, cytotoxic and regulatory T cells infiltrating into lesions may influence disease pathogenesis, the role of the T cell differentiation pattern of lymphocytes in lesions is unknown. Our aim was to investigate whether the phase of lesion development (early or late) is influenced by the functional status of cells present in inflammatory infiltrate...
August 2016: Clinical and Experimental Immunology
Marijana Curcic, Ksenija Durgo, Nevenka Kopjar, Mario Ancic, Slavica Vucinic, Biljana Antonijevic
In order to look into the combined effects of Cd and BDE-209 in vitro, this study was aimed at examining cytotoxic and genotoxic effects using the human colon carcinoma cell line (SW 480) as a biological test system as well as to determine if ROS production was one of the possible mechanisms of their mixture action. This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water...
September 2014: Environmental Toxicology and Pharmacology
Cristina Meregalli, Alessia Chiorazzi, Valentina A Carozzi, Annalisa Canta, Barbara Sala, Matteo Colombo, Norberto Oggioni, Cecilia Ceresa, Dana Foudah, Federica La Russa, Mariarosaria Miloso, Gabriella Nicolini, Paola Marmiroli, David Lh Bennett, Guido Cavaletti
Bortezomib (BTZ) is the first proteasome inhibitor entered in clinical practice. Peripheral neuropathy is likely to be a class side effect of these drugs, although its severity is largely variable, and it deserves to be further investigated, since the mechanisms of BTZ-induced peripheral neurotoxicity (BiPN) are still unknown.   In our study, we investigated in vivo and in vitro possible pathogenic events relevant to BiPN using a well-established rat model, with particular reference to the extent of proteasome inhibition and the effects on α-tubulin polymerization in sciatic nerves and dorsal root ganglia specimens obtained from animals treated with chronic regimens at a dose of 0...
2014: Cell Cycle
Svetlana Vojvodić, Stevan Popović
UNLABELLED: INTRODUCTION; Natural Killer cells (NK cells) represent the subset of peripheral lymphocytes that play critical role in the innate immune response to virus-infected and tumor transformed cells. Lysis of NK sensitive target cells could be mediated independently of antigen stimulation and without requirement of peptide presentation by the major histocompatibility complex (MHC) molecules. NK cell activity and functions are controlled by a considerable number of cell surface receptors, which exist in both inhibitory and activating isoforms...
January 2010: Medicinski Pregled
Daniela Morais Leme, Maria Aparecida Marin-Morales
Higher plants are recognized as excellent genetic models to detect environmental mutagens and are frequently used in monitoring studies. Among the plant species, Alium cepa has been used to evaluate DNA damages, such as chromosome aberrations and disturbances in the mitotic cycle. Employing the A. cepa as a test system to detect mutagens dates back to the 40s. It has been used to this day to assess a great number of chemical agents, which contributes to its increasing application in environmental monitoring...
July 2009: Mutation Research
Francesco Broccolo, Gianfranco Cainelli, Gianluigi Caltabiano, Clementina E A Cocuzza, Cosimo G Fortuna, Paola Galletti, Daria Giacomini, Giuseppe Musumarra, Rosario Musumeci, Arianna Quintavalla
The design, synthesis, and antibacterial activity of 4-alkyliden-azetidin-2-ones as new antimicrobial agents against multidrug-resistant pathogens is reported. 4-Alkyliden-azetidin-2-ones were easily obtained using an original protocol starting from 4-acetoxy-azetidinones and diazoesters. Parent compounds were further elaborated to obtain a small library of 4-alkylidene derivatives. A molecular modeling approach using GRID descriptors based on the concept of VRS identified attractive drug candidates and contributed to the rationalization of functional group effects in QSARs...
May 4, 2006: Journal of Medicinal Chemistry
Susana M Hernández, Marcela S Sánchez, Martha N Schwarcz de Tarlovsky
The polyamines, spermine and spermidine--organic polycations that are absolutely required for eukaryotic cell growth--are shown here to function in Trypanosoma cruzi epimastigotes, as protectors of membrane lipoperoxidation by reactive oxygen species generated either by H2O2/Fe2+ or nifurtimox. In vitro, spermine and spermidine inhibited lipoperoxidation in a dose dependent manner. Spermine was more efficient than spermidine in its inhibitory effect. Lipid peroxidation induced by H2O2 showed an IC50 of 0.55 mM for spermine and 0...
April 2006: Acta Tropica
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