keyword
MENU ▼
Read by QxMD icon Read
search

the contribution of citotoxic

keyword
https://www.readbyqxmd.com/read/27059407/effector-memory-cd4-t-cells-differentially-express-activation-associated-molecules-depending-on-the-duration-of-american-cutaneous-leishmaniasis-lesions
#1
C de Oliveira Mendes-Aguiar, R Vieira-Gonçalves, L H Guimarães, M P de Oliveira-Neto, E M Carvalho, A M Da-Cruz
A high number of Leishmania-responder T cells is found in cutaneous leishmaniasis lesions, suggesting that important immunological events occur at the site of infection. Although activated, cytotoxic and regulatory T cells infiltrating into lesions may influence disease pathogenesis, the role of the T cell differentiation pattern of lymphocytes in lesions is unknown. Our aim was to investigate whether the phase of lesion development (early or late) is influenced by the functional status of cells present in inflammatory infiltrate...
August 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25218094/cadmium-and-decabrominated-diphenyl-ether-mixture-in-vitro-evaluation-of-cytotoxic-prooxidative-and-genotoxic-effects
#2
Marijana Curcic, Ksenija Durgo, Nevenka Kopjar, Mario Ancic, Slavica Vucinic, Biljana Antonijevic
In order to look into the combined effects of Cd and BDE-209 in vitro, this study was aimed at examining cytotoxic and genotoxic effects using the human colon carcinoma cell line (SW 480) as a biological test system as well as to determine if ROS production was one of the possible mechanisms of their mixture action. This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water...
September 2014: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/24335344/evaluation-of-tubulin-polymerization-and-chronic-inhibition-of-proteasome-as-citotoxicity-mechanisms-in-bortezomib-induced-peripheral-neuropathy
#3
Cristina Meregalli, Alessia Chiorazzi, Valentina A Carozzi, Annalisa Canta, Barbara Sala, Matteo Colombo, Norberto Oggioni, Cecilia Ceresa, Dana Foudah, Federica La Russa, Mariarosaria Miloso, Gabriella Nicolini, Paola Marmiroli, David Lh Bennett, Guido Cavaletti
Bortezomib (BTZ) is the first proteasome inhibitor entered in clinical practice. Peripheral neuropathy is likely to be a class side effect of these drugs, although its severity is largely variable, and it deserves to be further investigated, since the mechanisms of BTZ-induced peripheral neurotoxicity (BiPN) are still unknown.   In our study, we investigated in vivo and in vitro possible pathogenic events relevant to BiPN using a well-established rat model, with particular reference to the extent of proteasome inhibition and the effects on α-tubulin polymerization in sciatic nerves and dorsal root ganglia specimens obtained from animals treated with chronic regimens at a dose of 0...
2014: Cell Cycle
https://www.readbyqxmd.com/read/20873317/-natural-killer-cells-biology-functions-and-clinical-relevance
#4
REVIEW
Svetlana Vojvodić, Stevan Popović
UNLABELLED: INTRODUCTION; Natural Killer cells (NK cells) represent the subset of peripheral lymphocytes that play critical role in the innate immune response to virus-infected and tumor transformed cells. Lysis of NK sensitive target cells could be mediated independently of antigen stimulation and without requirement of peptide presentation by the major histocompatibility complex (MHC) molecules. NK cell activity and functions are controlled by a considerable number of cell surface receptors, which exist in both inhibitory and activating isoforms...
January 2010: Medicinski Pregled
https://www.readbyqxmd.com/read/19577002/allium-cepa-test-in-environmental-monitoring-a-review-on-its-application
#5
REVIEW
Daniela Morais Leme, Maria Aparecida Marin-Morales
Higher plants are recognized as excellent genetic models to detect environmental mutagens and are frequently used in monitoring studies. Among the plant species, Alium cepa has been used to evaluate DNA damages, such as chromosome aberrations and disturbances in the mitotic cycle. Employing the A. cepa as a test system to detect mutagens dates back to the 40s. It has been used to this day to assess a great number of chemical agents, which contributes to its increasing application in environmental monitoring...
July 2009: Mutation Research
https://www.readbyqxmd.com/read/16640341/design-synthesis-and-biological-evaluation-of-4-alkyliden-beta-lactams-new-products-with-promising-antibiotic-activity-against-resistant-bacteria
#6
Francesco Broccolo, Gianfranco Cainelli, Gianluigi Caltabiano, Clementina E A Cocuzza, Cosimo G Fortuna, Paola Galletti, Daria Giacomini, Giuseppe Musumarra, Rosario Musumeci, Arianna Quintavalla
The design, synthesis, and antibacterial activity of 4-alkyliden-azetidin-2-ones as new antimicrobial agents against multidrug-resistant pathogens is reported. 4-Alkyliden-azetidin-2-ones were easily obtained using an original protocol starting from 4-acetoxy-azetidinones and diazoesters. Parent compounds were further elaborated to obtain a small library of 4-alkylidene derivatives. A molecular modeling approach using GRID descriptors based on the concept of VRS identified attractive drug candidates and contributed to the rationalization of functional group effects in QSARs...
May 4, 2006: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/16574050/polyamines-as-a-defense-mechanism-against-lipoperoxidation-in-trypanosoma-cruzi
#7
Susana M Hernández, Marcela S Sánchez, Martha N Schwarcz de Tarlovsky
The polyamines, spermine and spermidine--organic polycations that are absolutely required for eukaryotic cell growth--are shown here to function in Trypanosoma cruzi epimastigotes, as protectors of membrane lipoperoxidation by reactive oxygen species generated either by H2O2/Fe2+ or nifurtimox. In vitro, spermine and spermidine inhibited lipoperoxidation in a dose dependent manner. Spermine was more efficient than spermidine in its inhibitory effect. Lipid peroxidation induced by H2O2 showed an IC50 of 0.55 mM for spermine and 0...
April 2006: Acta Tropica
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"