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https://www.readbyqxmd.com/read/29463075/adverse-effects-of-doping-with-anabolic-androgenic-steroids-aas-in-competitive-athletics-recreational-sports-and-bodybuilding
#1
Elena Vorona, Eberhard Nieschlag
Despite the fact that sports organizations and legislators have introduced various mechanisms to discourage athletes from using performance and appearance enhancing substances a high percentage of athletes admits to their unabated application. In competitive athletics, bodybuilding and in recreational sports anabolic androgenic steroids (AAS) continue to be the substances most abused. This review summarizes the side effects of AAS abuse on organs and system functions in both sexes. High doses of AAS cause a significant increase of erythrocytes und haemoglobin concentration, which may lead to thromboembolism, intracardiac thrombosis and stroke...
February 19, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29456518/environmental-physiology-and-diving-medicine
#2
REVIEW
Gerardo Bosco, Alex Rizzato, Richard E Moon, Enrico M Camporesi
Man's experience and exploration of the underwater environment has been recorded from ancient times and today encompasses large sections of the population for sport enjoyment, recreational and commercial purpose, as well as military strategic goals. Knowledge, respect and maintenance of the underwater world is an essential development for our future and the knowledge acquired over the last few dozen years will change rapidly in the near future with plans to establish secure habitats with specific long-term goals of exploration, maintenance and survival...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29433896/generating-tissue-resident-macrophages-from-pluripotent-stem-cells-lessons-learned-from-microglia
#3
Christel Claes, Johanna Van den Daele, Catherine M Verfaillie
Over the past decades, the importance of the immune system in a broad scope of pathologies, has drawn attention towards tissue-resident macrophages, such as microglia in the brain. To enable the study of for instance microglia, it is crucial to recreate in vitro (and in vivo) assays. However, very fast loss of tissue-specific features of primary tissue resident macrophages, including microglia, upon in vitro culture has complicated such studies. Moreover, limited knowledge of macrophage developmental pathways and the role of local 'niche factors', has hampered the generation of tissue-resident macrophages from pluripotent stem cells (PSC)...
February 2, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29417823/drug-induced-pulmonary-arterial-hypertension-a-primer-for-clinicians-and-scientists
#4
Mark E Orcholski, Ke Yuan, Charlotte Rajasingh, Halley Tsai, Elya A Shamskhou, Navneet Kaur Dhillon, Norbert F Voelkel, Roham T Zamanian, Vinicio A de Jesus Perez
Drug-induced pulmonary arterial hypertension (D-PAH) is a form of World Health Organization (WHO) Group 1 pulmonary hypertension (PH) defined by severe small vessel loss and obstructive vasculopathy, which leads to progressive right heart failure and death. To date, 16 different compounds have been associated with D-PAH, including anorexigens, recreational stimulants, and more recently, several Food and Drug Administration (FDA)-approved medications. While the clinical manifestation, pathology, and hemodynamic profile of D-PAH are indistinguishable from other forms of PAH, its clinical course can be unpredictable and to some degree dependent on removal of the offending agent...
February 8, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29409092/-gallop-in-the-routineergometrie-only-chore-or-diagnostic-challenge
#5
Stephan Knöchner, K Kronberg, U Schumann
ANAMNESIS:  A 47-year-old recreational sportsman showed in a routine ergometry polymorphic ventricular extrasystoles with good physical performance. INVESTIGATIONS:  In resting ECG impressed ventricular extrasystoles (VES) predominantly right-hand-block-like with superior axis, a long-term ECG yielded up to 100 VES per hour. Echocardiographically imposing 4 - 5 trabeculae, feathered, reticular structures apically in the left and lower in the right ventricle...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29390165/satisfaction-with-cancer-care-self-efficacy-and-health-related-quality-of-life-in-latino-cancer-survivors
#6
Patricia I Moreno, Amelie G Ramirez, Sandra L San Miguel-Majors, Rina S Fox, Leopoldo Castillo, Kipling J Gallion, Edgar Munoz, Ryne Estabrook, Arely Perez, Thomas Lad, Courtney Hollowell, Frank J Penedo
BACKGROUND: The objective of the current study was to examine how modifiable factors such as satisfaction with cancer care and self-efficacy impact health-related quality of life (HRQOL) among Latino cancer survivors. METHODS: Latinos previously diagnosed with breast, prostate, or colorectal cancer (N = 288) completed questionnaires (Patient Satisfaction with Cancer Care Scale, Stanford Chronic Disease Self-Management Measures, Functional Assessment of Cancer Therapy-General, and Short Acculturation Scale for Hispanics) within 2 years after receiving primary cancer treatment...
February 1, 2018: Cancer
https://www.readbyqxmd.com/read/29381329/fabrication-of-hemin-doped-serum-albumin-based-fibrous-scaffolds-for-neural-tissue-engineering-applications
#7
Chia-Chen Hsu, Andrea Serio, Nadav Amdursky, Cyril Besnard, Molly M Stevens
Neural tissue engineering (TE) represents a promising new avenue of therapy to support nerve recovery and regeneration. To recreate the complex environment in which neurons develop and mature, the ideal biomaterials for neural TE require a number of properties and capabilities including the appropriate biochemical and physical cues to adsorb and release specific growth factors. Here, we present neural TE constructs based on electrospun serum albumin (SA) fibrous scaffolds. We doped our SA scaffolds with an iron-containing porphyrin, hemin, to confer conductivity, and then functionalized them with different recombinant proteins and growth factors to ensure cell attachment and proliferation...
January 30, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29372350/bilateral-vision-loss-due-to-leber-s-hereditary-optic-neuropathy-after-long-term-alcohol-nicotine-and-drug-abuse
#8
Johanna Maass, Egbert Matthé
PURPOSE: Leber's hereditary optic neuropathy is relatively rare, and no clinical pathognomonic signs exist. We present a rare case of bilateral vision loss of a patient with multiple drug abuse in the history. OBSERVATION: A 31-year-old man presented with a history of progressive, decreased vision in both eyes for 6 month. On examination, his visual acuity was hand motion in both eyes. Funduscopy demonstrated a temporal pallor of the optic disc. Goldmann visual field perimetry showed a crescent visual field in the right eye and a circular decrease to less than 50 ° in the left eye...
January 25, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29344464/cannabinoids-in-the-treatment-of-epilepsy-hard-evidence-at-last
#9
REVIEW
Emilio Perucca
The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ(9) - tetrahydrocannabinol (THC), utilized primarily for recreational purposes, are generally unsuitable for this indication, primarily because THC is associated with many undesired effects. Compared with THC, cannabidiol (CBD) shows a better defined anticonvulsant profile in animal models and is largely devoid of adverse psychoactive effects and abuse liability...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29340129/protective-isolation-for-patients-with-haematological-malignancies-a-pilot-study-investigating-patients-distress-and-use-of-time
#10
O Annibali, C Pensieri, V Tomarchio, V Biagioli, M Pennacchini, A Tendas, V Tambone, M C Tirindelli
Background: Patients with haematological malignancies are often hospitalized in protective isolation until full neutrophil recovery in order to prevent infections. This descriptive pilot study evaluate the level of isolation-related distress and the use of free time in a sample of Italian onco-haematological patients who were hospitalized in protective isolation. Materials and Methods: Participants were 18 patients hospitalized in hematologic ward to receive induction therapy (n=12) or autologous stem cell transplant (n=6)...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29321937/marijuana-bong-pseudomonas-lung-infection-a-detrimental-recreational-experience
#11
Agni Nhirmal Kumar, Chun Ian Soo, Boon Hau Ng, Tidi Hassan, Andrea Yu-Lin Ban, Roslina Abdul Manap
The use of Cannabis sativa, also known as marijuana, is believed to have dated back to thousands of years B.C. More than 200 decades later, it remains a popular recreational psychoactive substance that can be smoked through a water pipe. We report a case of marijuana smoking via a "bong" device, which has resulted in severe Pseudomonas aeruginosa necrotizing pneumonia treated with conservative medical therapy. This case highlights the importance of recognizing that life-threatening pneumonia can potentially be linked to marijuana and "bong" usage...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29311404/recreational-drug-and-psychosocial-profile-in-chronic-hepatitis-c-patients-seeking-antiviral-therapy
#12
Nayana George, Sherrie M Harrell, Kimberly D Rhodes, Andres Duarte-Rojo
BACKGROUND AND AIMS: Practitioners treating hepatitis C (HCV) provide healthcare to a special population with high rates of substance abuse and psychiatric disorders. We investigated the psychosocial profile in HCV patients and tested what variables affect commencement of antiviral therapy. MATERIAL AND METHODS: Recreational drug use (RDU), marijuana (THC), alcohol use, and psychiatric history were initially investigated with a questionnaire prior to history and physical...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29289268/rhabdomyolysis-associated-acute-kidney-injury-with-normal-creatine-phosphokinase
#13
Faisal Kamal, Lindsay Snook, Jagannath H Saikumar
Rhabdomyolysis is a syndrome characterized by the breakdown of skeletal muscle and leakage of intracellular myocyte contents, such as creatine phosphokinase (CPK) and myoglobin, into the interstitial space and plasma resulting in acute kidney injury (AKI). Elevated CPK of at least 5 times the upper limit of normal is an important diagnostic marker of Rhabdomyolysis. We present a case of rhabdomyolysis with severe AKI with a normal CPK at presentation. A 32-year-old man presented with acute respiratory failure and AKI after an overdose of recreational drugs...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29276600/atraumatic-bilateral-rupture-of-the-peroneus-brevis-tendon-in-recreational-sport-a-case-report
#14
Patric Scheidegger, Lukas Weisskopf, Anja Hirschmüller
Issue: Lower extremity tendon injuries often occur in physically active individuals. Most ruptures not involving great force are diagnosed in patients presenting underlying tendon degenerations. This also applies to patients taking medications because of a disease. We have observed several cases of bilateral Achilles tendon ruptures in patients who have been taking cortisone for a long period. We treated a healthy colleague (neurologist) in our clinic who sustained ruptures of the Achilles tendon on the left side (2012) and the peroneus brevis tendon on left side (2015) and right side (2016) after minimal traumata...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29250737/a-prospective-observational-study-of-problematic-oral-cannabinoid-use
#15
Mark A Ware, Marc O Martel, Roman Jovey, Mary E Lynch, Joel Singer
BACKGROUND: Despite evidence supporting the benefits of cannabinoids for symptom control across a wide range of medical conditions, concerns have been raised regarding the potential misuse and/or problematic use of cannabinoids (CBs). OBJECTIVE: The first objective of this study was to examine the incidence of problematic prescription cannabinoid use (PPCBU) over a 12-month period among patients initiating cannabinoid therapy. The second objective was to examine the factors associated with PPCBU...
December 17, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29233687/interferon-free-direct-acting-antiviral-therapy-for-acute-hepatitis-c-virus-infection-in-hiv-infected-individuals-a-literature-review
#16
REVIEW
Temi Lampejo, Kosh Agarwal, Ivana Carey
Dramatic rises in hepatitis C virus (HCV) coinfection rates in human immunodeficiency virus (HIV)-infected individuals have been observed recently, largely attributable to increasing recreational drug use combined with increased testing for HCV. In the era of direct-acting antiviral (DAA) therapy, treatment of acute HCV infection in HIV-infected individuals with short durations of these drugs may potentially reduce the disease and economic burden associated with HCV infection as well as reducing the likelihood of onward HCV transmission...
November 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29212511/comparing-the-chinese-versions-of-two-knee-specific-questionnaires-ikdc-and-koos-reliability-validity-and-responsiveness
#17
Chien-Chih Huang, Wen-Shiang Chen, Mei-Wun Tsai, Wendy Tzyy-Jiuan Wang
BACKGROUND: The International Knee Documentation Committee Subjective Knee Form (IKDC) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) are knee-specific questionnaires that have been widely used and translated into numerous languages. However, the differences in the psychometric properties between the Chinese IKDC and KOOS remain unclear. The purpose of this study was to conduct a cross-cultural adaptation of the Chinese IKDC and Chinese KOOS and to compare the psychometric properties of these two measures in patients with various knee injuries from the acute stage up to 12 weeks after receiving treatment...
December 6, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29184512/strategies-developed-to-induce-direct-and-potentiate-bone-healing
#18
REVIEW
Anne-Margaux Collignon, Julie Lesieur, Christian Vacher, Catherine Chaussain, Gael Y Rochefort
Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies, including several biomolecules, cellular therapies, biomaterials, and different permutations of these, are now developed to facilitate the vascularization and the engraftment of the constructs, to recreate ultimately a bone tissue with the same properties and characteristics of the native bone...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29160600/current-evidence-of-cannabinoid-based-analgesia-obtained-in-preclinical-and-human-experimental-settings
#19
REVIEW
J Lötsch, I Weyer-Menkhoff, I Tegeder
Cannabinoids have a long record of recreational and medical use and become increasingly approved for pain therapy. This development is based on preclinical and human experimental research summarized in this review. Cannabinoid CB 1 receptors are widely expressed throughout the nociceptive system. Their activation by endogenous or exogenous cannabinoids modulates the release of neurotransmitters. This is reflected in antinociceptive effects of cannabinoids in preclinical models of inflammatory, cancer and neuropathic pain, and by nociceptive hypersensitivity of cannabinoid receptor-deficient mice...
November 21, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29132327/explaining-variance-in-self-directed-learning-readiness-of-first-year-students-in-health-professional-programs
#20
Craig E Slater, Anne Cusick, Jimmy C Y Louie
BACKGROUND: Self-directed learning (SDL) is expected of health science graduates; it is thus a learning outcome in many pre-certification programs. Previous research identified age, gender, discipline and prior education as associated with variations in students' self-directed learning readiness (SDLR). Studies in other fields also propose personality as influential. METHOD: This study investigated relationships between SDLR and age, gender, discipline, previous education, and personality traits...
November 13, 2017: BMC Medical Education
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