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https://www.readbyqxmd.com/read/29148415/exacerbation-of-beh%C3%A3-et-s-syndrome-and-familial-mediterranean-fever-with-menstruation
#1
Gul Guzelant, Yesim Ozguler, Sinem Nihal Esatoglu, Guzin Karatemiz, Huri Ozdogan, Sebahattin Yurdakul, Hasan Yazici, Emire Seyahi
OBECTIVES: Menstruation triggers several conditions such as migraine, recurrent aphthous stomatitis and acne vulgaris in healthy individuals. There is evidence that Behçet's syndrome (BS) and familial Mediterranean fever (FMF) may exacerbate during menstruation. The aim is to assess whether BS and FMF patients experience menstrual flares. METHODS: Females of reproductive age with BS and FMF seen consecutively at the outpatient clinic of Cerrahpasa Medical Faculty at Istanbul, as well as apparently healthy hospital workers were studied using a standardised questionnaire...
October 24, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29128948/a-dramatic-case-of-odynophagia
#2
B Sopeña, J Limeres, L García-Caballero, M Diniz-Freitas, J Seoane, P Diz
We report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. The severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ENT, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). During this time, the patient received central parenteral nutrition with an episode of catheter-related septicemia, and he came to require psychiatric assistance for autolytic ideation...
November 11, 2017: Dysphagia
https://www.readbyqxmd.com/read/29098253/-the-role-of-food-specific-igg-antibody-test-in-diagnosis-and-treatment-of-mild-recurrent-aphthous-ulcer
#3
Yan DU, Yue-Lei Xing, Lei Ji, Xian-Hua Zhang
PURPOSE: To evaluate the role of food-specific IgG antibody test in the treatment of mild recurrent aphthous ulcer. METHODS: Seven hundred and ninety nine mild recurrent aphthous ulcer patients and 762 normal persons were enrolled in the experimental and control group respectively, based on the criteria for inclusion and exclusion. The blood serum samples of them were obtained to detect food-specific IgG antibody by enzyme-linked immunosorbent assay. The positive rates were then compared by Chi-square test between 2 groups using SPSS 17...
June 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29095300/rare-esophageal-ulcers-related-to-beh%C3%A3-et-disease-a-case-report
#4
Ning Jia, Yanping Tang, Huayi Liu, Yang Li, Simiao Liu, Lei Liu
RATIONALE: The fundamental pathogenesis of Behçet disease (BD) is still unclear and controversial. Many cases of oral aphthous ulcers and genital ulcers related to BD are reported; nevertheless, idiopathic giant esophageal ulcers related to BD are rare. A rare case for esophageal ulcers related to BD is presented. PATIENT CONCERNS: In China, BD is represented with esophageal involvement which is called esophageal BD (EBD). DIAGNOSES: A 56-year-old man diagnosed to the Gastroenterology Department of Integrated Traditional Chinese and Western Medicine Hospital, for multiple discrete, elliptical esophageal ulcers related to BD...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29071227/formulation-and-optimization-of-oral-mucoadhesive-patches-of-myrtus-communis-by-box-behnken-design
#5
Mahbubeh Hashemi, Vahid Ramezani, Mohammad Seyedabadi, Ali Mohamad Ranjbar, Hossein Jafari, Mina Honarvar, Hamed Fanaei
Purpose: Recurrent aphthous stomatitis (RAS) is the most common painful ulcerative disease of oral mucosa happening in ~20% of people. Aimed to develop Myrtus communis L. (Myrtle) containing oral patches, we applied box-behnken design to evaluate the effect of polymers such as Polyvinyl pyrrolidone (PVP), Gelatin, Methylcellulose (MC) and Pectin. Methods: The patches properties such as tensile strength, folding endurance, swelling index, thickness, mucoadhesive strength and the pattern of myrtle release were evaluated as dependent variables...
September 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29067849/investigation-of-dissolved-cellulose-in-development-of-buccal-discs-for-oromucosal-drug-delivery
#6
Emrah Yildir, Erica Sjöholm, Maren Preis, Poonam Trivedi, Jani Trygg, Pedro Fardim, Niklas Sandler
Mucoadhesive formulations have a wide scope of application for both systemic and local treatment of various diseases. In the case of recurrent aphthous stomatitis, to ensure effective therapy, the concentration of corticosteroids and/or anesthetics at the mouth ulcer side should be maintained with minimal systemic absorption. Therefore, the aim of the study was to investigate cellulose-based formulations, in achieving suitable hardness, mucoadhesiveness and sustained release of the active ingredients directed towards the mucosa for an extended period of time (approx...
October 25, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29025800/approach-to-recurrent-fever-in-childhood
#7
REVIEW
Gordon S Soon, Ronald M Laxer
OBJECTIVE: To provide an approach to recurrent fever in childhood, explain when infections, malignancies, and immunodeficiencies can be excluded, and describe the features of periodic fever and other autoinflammatory syndromes. SOURCES OF INFORMATION: PubMed was searched for relevant articles regarding the pathogenesis, clinical findings, diagnosis, prognosis, and treatment of periodic fever and autoinflammatory syndromes. MAIN MESSAGE: Fever is a common sign of illness in children and is most frequently due to infection...
October 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28979866/cutaneous-manifestations-of-chikungunya-fever-observations-from-an-outbreak-at-a-tertiary-care-hospital-in-southeast-rajasthan-india
#8
Ramesh Kumar, Manoj K Sharma, Suresh K Jain, Sumit K Yadav, Anil K Singhal
BACKGROUND: Chikungunya fever is caused by chikungunya virus which is transmitted by the bite of infected Aedes aegypti and A. albopictus mosquitoes. AIMS: To study the various mucocutaneous manifestations in suspected cases of chikungunya fever. MATERIALS AND METHODS: The patients who attended our outpatient department from July 2016 to October 2016 and fulfilled the criteria for "suspect cases" of chikungunya infection stipulated by the National Institute of Communicable Diseases, Directorate General of Health Services, Government of India, were included in the study prospectively...
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28970828/diagnostic-criteria-for-adult-onset-periodic-fever-aphthous-stomatitis-pharyngitis-and-cervical-adenitis-pfapa-syndrome
#9
Luca Cantarini, Antonio Vitale, Ludovico Luca Sicignano, Giacomo Emmi, Elena Verrecchia, Isabella Patisso, Lucia Cerrito, Claudia Fabiani, Gabriele Cevenini, Bruno Frediani, Mauro Galeazzi, Donato Rigante, Raffaele Manna
OBJECTIVE: To identify a set of variables that could discriminate patients with adult-onset periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome from subjects with fever of unknown origin (FUO). METHODS: We enrolled 74 adults diagnosed with PFAPA syndrome according to the currently used pediatric diagnostic criteria and 62 additional patients with FUO. After having collected clinical and laboratory data from both groups, univariate and multivariate analyses were performed to identify the variables associated with PFAPA diagnosis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28958141/oral-manifestations-of-inflammatory-bowel-disease
#10
I Mortada, A Leone, A Gerges Geagea, R Mortada, C Matar, M Rizzo, I Hajj Hussein, L Massaad-Massade, A Jurjus
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, have important extraintestinal manifestations, notably in the oral cavity. These oral manifestations can constitute important clinical clues in the diagnosis and management of IBD, and include changes at the immune and bacterial levels. Aphthous ulcers, pyostomatitis vegetans, cobblestoning and gingivitis are important oral findings frequently observed in IBD patients. Their presentations vary considerably and might be well diagnosed and distinguished from other oral lesions...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28950260/beyond-hla-class-i-antigens-hfe-mutations-in-recurrent-aphthous-oral-ulcers-and-beh%C3%A3-et-s-disease-in-the-south-of-tunisia
#11
El Aoud Sahar, Arwa Kamoun, Nadia Mahfoudh, Aida Charfi, Mouna Snoussi, Hend Hachicha, Ameni Jerbi, Chifa Dammak, Faten Frikha, Faiza Hakim, Lilia Gaddour, Zouhair Bahloul, Hafedh Makni
<br>To establish HLA class I and HFE mutation associations with recurrent aphthous oral ulcers (RAOU) and Behçet disease (BD) in a cohort of Southern Tunisian patients.<br> Materials (Subjects) and Methods<br>A total of 232 patients with RAOU and 123 healthy controls (HC) were enrolled in our study. Patients were divided into 2 groups based on the presence (BD+: 62) or not (BD-: 170). In the BD+ group, 28 patients had a severe form. In the (BD-) group, RAOU was isolated in 81 patients, associated with mucocutaneous manifestations in 58 patients and with joint symptoms in 25 patients...
September 26, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28942153/the-absence-of-an-association-between-interleukin-1%C3%AE-gene-polymorphisms-and-recurrent-aphthous-stomatitis-ras
#12
Zuzanna Ślebioda, Anna Kowalska, Marta Rozmiarek, Ewa Krawiecka, Elżbieta Szponar, Barbara Dorocka-Bobkowska
OBJECTIVES: Recurrent aphthous stomatitis (RAS) is a chronic, ulcerative disease with a probable polygenic mode of inheritance and complex etiology with a strong immunological background. The aim of the present study was to determine the possible association between two single nucleotide polymorphisms (SNPs) of the IL-1β gene: IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) and RAS susceptibility in a moderately large group of patients. DESIGN: One hundred and four patients with minor, major and herpetiform RAS and 75 healthy volunteers were genotyped at IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) using the PCR-RFLP approach...
September 19, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28922104/interleukin-2-interferon-gamma-gene-polymorphisms-in-recurrent-aphthous-stomatitis
#13
Shamsolmoulouk Najafi, Hila Yousefi, Mahsa Mohammadzadeh, Alireza Zare Bidoki, Elham Farhadi, Nima Rezaei
Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative inflammatory disease with unknown etiology. IL-2 and IFN-γ are secreted by Th1 cells and the elevated levels of them have been reported in RAS. Single nucleotide polymorphisms (SNPs) of IL-2 and IFN-γ genes could alter the cytokine production. The aim of this study was to investigate frequencies of IL-2 and IFN-γ alleles and genotypes in a group of patients with minor-RAS (MiRAS). PCR-SSP method used to type genomic DNA of 64 Iranian patients with MiRAS for IL-2 gene (G -330 T) and (G +166 T) and IFN-γ gene at position UTR5644 (A/T)...
2017: Prague Medical Report
https://www.readbyqxmd.com/read/28916023/beh%C3%A3-et-disease-new-aspects
#14
Isil Bulur, Meltem Onder
Behçet disease is currently considered an "autoinflammatory disease" triggered by infection and environmental factors in genetically predisposed individuals. Although the disease is characterized by recurrent oral and genital aphthous ulcers and ocular involvement, it can affect multiple organ systems. Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. It is important to evaluate the patient with complex aphthosis for Behçet disease and related systemic disorders. We discuss the etiopathogenesis, clinical features, diagnostic criteria, and treatment approaches for complex aphthosis and Behçet disease in light of the current literature...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28915309/genital-aphthous-ulcers-and-a-case-of-suspected-chikungunya-a-short-clinical-case
#15
Frances A Martinez-Díaz
Genital aphthous ulcers can result from multiple conditions including febrile syndromes. Chikungunya infection manifests mainly as fever accompanied by polyarthralgia and pruritic rash. Nevertheless, healthcare providers should be alert to additional presentations. This is the case of a young woman presenting with painful genital ulcers after a three day prodome of fever and polyarthralgia. As a suspected case of Chikungunya infection and a clinical diagnosis of aphthae, treatment with oral prednisone for two weeks produced complete resolution of ulcers with no scarring...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28884141/apremilast-for-treatment-of-recalcitrant-aphthous-stomatitis
#16
Fabian Schibler, Kristine Heidemeyer, Hans-Willhelm Klötgen, Vinay Keshavamurthy, Nikhil Yawalkar
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28882091/measles-lymphadenopathy-in-a-child-with-pfapa-syndrome
#17
Jefferson Terry, Kelly Brown, Joanne Hiebert, Ghada N Al-Rawahi, J Paul Moxham, Mel Krajden, Agatha N Jassem, Lori Tucker
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a common cause of periodic fever in children. The pathogenesis of PFAPA is unknown but likely involves immune system dysregulation and may be initiated by an environmental trigger. Tonsillectomy resolves or improves symptoms in some patients, but the reason for this is unknown; moreover, specific abnormalities in tonsillectomy specimens from PFAPA patients have not been described. Here, we report measles virus in tonsil from a child with PFAPA...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28871816/comparative-pharmacokinetics-study-of-five-alkaloids-in-rat-plasma-and-related-compound-herb-interactions-mechanism-after-oral-administration-of-shuanghua-baihe-tablets
#18
Xinyu Zhao, Yan Wang, Lu Zheng, Chengpeng Sun, Chao Wang, Haijian Cong, Ting Xiang, Lin Zhang, Houli Zhang, Sa Deng, Baojing Zhang, Bin Wu, Xiaokui Huo
Shuanghua Baihe tablet is a traditional Chinese patent medicine which showed special advantages in the treatment of recurrent aphthous stomatitis. Scientists have improved and implemented the LC-MS/MS method, which is specific and sensitive, for comparative pharmacokinetics study of five alkaloids, including palmatine, berberine, epiberberine, jatrorrhizine and coptisine in rat plasma after oral administration of Rhizoma Coptidis extract and Shuanghua Baihe tablets. The results showed that Shuanghua Baihe tablets could promote the absorption of these five alkaloids and improved their bioavailability compared with R...
September 5, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28847142/stress-as-a-cause-of-recurrent-aphthous-stomatitis-and-its-correlation-with-salivary-stress-markers
#19
Kirthana Kunikullaya U., Arun Kumar M., Vasanthi Ananthakrishnan, Goturu Jaisri
Stress causes an increase in cortisol and amylase. Recurrent aphthous stomatitis (RAS) results due to a multitude of causes, amongst which stress is one of the most important. Aim of the study was to estimate the level of stress, serum cortisol, salivary cortisol, amylase and electrolytes in subjects with RAS. 34 subjects with RAS (cases) were compared with 34 controls. Stress was measured using state trait anxiety inventory (STAI). Serum cortisol (Radioimmunoassay), Salivary cortisol, amylase (ELISA) and electrolytes (Flame photometry) were measured...
August 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28839413/evaluation-of-salivary-cortisol-changes-and-psychological-profiles-in-patients-with-recurrent-aphthous-stomatitis
#20
Fatemeh Rezaei, Maziar Aminian, Asad Vaisi Raygani
BACKGROUND AND OBJECTIVE: Some studies suggest that psychological condition and stress can play role in the development of recurrent aphthous stomatitis (RAS). The purpose of this study was to evaluate salivary cortisol changes and psychological conditions in patients with RAS. MATERIALS AND METHODS: Twenty-seven patients (13 males and 14 females, mean age of 32.8 (±10.2) years) with minor RAS and 27 age- and sex-matched controls without RAS participated in this study...
April 2017: Contemporary Clinical Dentistry
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