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https://www.readbyqxmd.com/read/29169204/newborn-genetic-screening-for-spinal-muscular-atrophy-in-the-uk-the-views-of-the-general-population
#1
Felicity K Boardman, Chloe Sadler, Philip J Young
BACKGROUND: Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder and a leading genetic cause of infant death worldwide. However, there is no routine screening program for SMA in the UK. Lack of treatments and the inability of screening tests to accurately predict disease severity are among the key reasons implementation of screening has faltered in the UK. With the recent release of the first therapy for SMA (Nusinersen), calls are being made for a reconsideration of this stance; however, very little is known about the views of the general public...
November 23, 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29169145/early-results-on-canine-fetal-kidney-development-ultrasonographic-evaluation-and-value-in-prediction-of-delivery-time
#2
Elaine Mayumi Ueno Gil, Daniela Aparecida Ayres Garcia, Amália Turner Giannico, Tilde Rodrigues Froes
To date there have been no studies that describe the ultrasonographic evaluation of kidney development in canine fetuses. The aim of this prospective and longitudinal study was to monitor fetal kidney development with ultrasound and use fetal kidney measurements as a complementary biometric index for estimation of gestational age. Ultrasonographic examinations were performed on 15 clinically healthy pregnant bitches every four days from 30(th) day of pregnancy, until visualization of the fetal renal pelvis was no longer possible...
November 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/29169099/exposure-to-arsenic-in-tap-water-and-gestational-diabetes-a-french-semi-ecological-study
#3
Cécile Marie, Stéphanie Léger, Aline Guttmann, Olivier Rivière, Nathalie Marchiset, Didier Lémery, Françoise Vendittelli, Marie-Pierre Sauvant-Rochat
INTRODUCTION: The increase in the prevalence of gestational diabetes mellitus (GDM) and its consequences for mother and children prompts research on their risk factors including environmental factors. Studies on exposure to arsenic (As) in tap water and the risk of GDM have not provided conclusive evidence, particularly when levels of exposure were low (from 10 to 50µg As/L). The main objective of this study was to assess the association between exposure to As in tap water and the risk of GDM...
November 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/29169084/changes-in-first-trimester-fetal-cyp1a1-and-ahrr-dna-methylation-and-mrna-expression-in-response-to-exposure-to-maternal-cigarette-smoking
#4
Svetlana Fa, Trine Vilsbøll Larsen, Katrine Bilde, Tina F Daugaard, Emil H Ernst, Karin Lykke-Hartmann, Rasmus H Olesen, Linn S Mamsen, Erik Ernst, Agnete Larsen, Anders L Nielsen
Prenatal exposure to maternal cigarette smoking increases the risk of intrauterine growth retardation, adverse pregnancy outcomes, and diseases later in life. Exposure can result in postnatal global and gene-specific DNA methylation changes, with the latter well documented for the CYP1A1 and AHRR genes involved in the detoxification of xenobiotic substances. This study assessed the impact of exposure to maternal smoking on first trimester fetal CYP1A1 and AHRR mRNA expression and DNA methylation for CpG-sites displaying maternal smoking during pregnancy-mediated methylation changes at birth...
November 16, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29169057/synthetic-social-support-theorizing-lay-health-worker-interventions
#5
Nicola K Gale, Sara Kenyon, Christine MacArthur, Kate Jolly, Lucy Hope
Levels of social support are strongly associated with health outcomes and inequalities. The use of lay health workers (LHWs) has been suggested by policy makers across the world as an intervention to identify risks to health and to promote health, particularly in disadvantaged communities. However, there have been few attempts to theorize the work undertaken by LHWs to understand how interventions work. In this article, the authors present the concept of 'synthetic socialsupport' and distinguish it from the work of health professionals or the spontaneous social support received from friends and family...
November 8, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29168999/investigating-the-perceived-benefits-barriers-and-beliefs-towards-physical-activity-in-pregnancy-among-women-with-gestational-diabetes-mellitus
#6
C Hurst, C Flannery, M Byrne, P M Kearney, F Dunne, M O'Riordan, J C Walsh
Gestational Diabetes Mellitus (GDM) is a growing concern and poses serious health risks to both mother and child1. The current study explores the psychological determinants of exercise behaviour in a sample of pregnant women with GDM. A cross-sectional survey design was employed to examine exercise behaviour, illness perceptions, perceived barriers and benefits, exercise beliefs, and exercise self-efficacy using validated questionnaires. A sample of 46 pregnant women was recruited from University College Hospital Galway, Letterkenny General Hospital, Cork University Hospital and Mayo General Hospital in Castlebar...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168964/using-theory-of-planned-behavior-for-prediction-of-delivery-mode-among-pregnant-women-a-theory-based-cross-sectional-research
#7
Mohtasham Ghaffari, Atefeh Afshari, Sakineh Rakhshanderou, Bahram Armoon
Background Nowadays, in Iran cesarean rates have increased from the recommended level of the World Health Organization (WHO). Objectives The objective of the present study was to determine which theory of planned behavior (TPB) constructs predict intentions and delivery mode among pregnant women. Methods One hundred and four pregnant nulliparous women in their third trimesters of pregnancy referred to Semirom health care centers were investigated based on census reports. The data were collected by valid and reliable questionnaire based on the TPB constructs and analyzed by SPSS16...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168959/effect-of-a-brief-training-program-for-primigravid-adolescents-on-parenting-self-efficacy-and-mother-infant-bonding-in-the-southeast-of-iran
#8
Zahra Moudi, Behjat Talebi, Mahnaz Shahraki Pour
Background Annually, about 16 million adolescent girls give birth, accounting for 11% of all births worldwide. Ninety-five percent of these births occur in low- and middle-income countries, and previous studies have addressed the need for parenting interventions in developing countries with limited health care resources to improve parenting behaviors. Objective To explore the effect of a brief training program for primigravid adolescents on parenting self-efficacy and mother-infant bonding. Subjects We enrolled 116 married pregnant adolescents...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168736/association-between-vitamin-intake-during-pregnancy-and-risk-of-small-for-gestational-age
#9
Inmaculada Salcedo-Bellido, Juan Miguel Martínez-Galiano, Rocío Olmedo-Requena, Juan Mozas-Moreno, Aurora Bueno-Cavanillas, Jose J Jimenez-Moleon, Miguel Delgado-Rodríguez
Pregnancy increases the requirements of certain nutrients, such as vitamins, to provide nutrition for the newborn. The aim was to analyze the association between dietary intake of vitamins during pregnancy and risk of having a small for gestational age (SGA) newborn. A matched case-control study was conducted (518 cases and 518 controls of pregnant women) in Spain. Dietary vitamin intake during pregnancy was assessed using a validated food frequency questionnaire, categorized into quintiles. Odds ratios (ORs) and their 95% confidence intervals (CI) were estimated with conditional regression logistic models...
November 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29168589/time-to-delivery-transfers-for-threatened-preterm-labour-and-prelabour-rupture-of-membranes-in-western-australia
#10
Jade Hollingworth, Rachel Pietsch, Mathias Epee-Bekima, Elizabeth Nathan
OBJECTIVE: To describe the outcomes of patients transferred to King Edward Memorial Hospital (KEMH) with signs of labour at preterm gestations. DESIGN: A retrospective observational study of the 69 cases transferred to KEMH during 2015. SETTING: Patient transfers from all locations across Western Australia (WA) to the sole tertiary perinatal centre in Perth. PARTICIPANTS: Pregnant women within WA with threatened or actual preterm labour (PTL) or preterm prelabour rupture of membranes (PPROM) between 23 and 32 weeks gestation...
November 23, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29168588/ovarian-response-to-controlled-ovarian-stimulation-for-fertility-preservation-before-oncology-treatment-a-retrospective-cohort-of-157-patients
#11
Nikolaos Tsampras, Stephen A Roberts, Della Gould, Cheryl T Fitzgerald
This is a retrospective cohort study aiming to examine the response of oncology patients undergoing controlled ovarian stimulation (COS) for fertility preservation and to review the incidence of short-term complications. The study group consisted by all oncology patients undergoing ovarian stimulation for fertility preservation (n = 157) between April 2009 and April 2016. Patients undergoing COS for IVF/ICSI for male factor only infertility in the same time period (n = 2,128) provided a comparator group...
November 23, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29168561/combination-therapy-with-mifepristone-and-misoprostol-for-the-management-of-first-trimester-miscarriage-improved-success
#12
Angela Dunford, Rina Fyfe
BACKGROUND: First trimester miscarriage affects 20% of pregnancies. Medical management has a high degree of patient acceptance and does not increase the risk of infection. Mifepristone is an anti-progesterone shown to improve outcomes when used in conjunction with misoprostol for first trimester abortion. However, there have been conflicting results when it has been added to treatment regimens for miscarriage. METHODS: We performed a retrospective cohort analysis of women presenting to the Acute Gynaecology Service of our tertiary referral centre for miscarriage management from December 2010 until December 2013...
November 23, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29168438/impact-of-sex-composition-of-living-children-and-couples-agreement-on-subsequent-fertility-in-india
#13
Anshul Kastor, Sayantani Chatterjee
The desire for children could be considered a reliable predictor of subsequent fertility. At the same time, the sex composition of surviving children, along with other demographic and socioeconomic factors, may affect a couple's fertility desire and, therefore, their subsequent fertility. This study examined the impact of the sex composition of living children and a couple's agreement on fertility desire on their subsequent fertility in India using data came from two rounds of nationally representative surveys: the India Human Development Survey (IHDS)-I (2004-05) and IHDS-II (2011-12)...
November 23, 2017: Journal of Biosocial Science
https://www.readbyqxmd.com/read/29168294/association-of-prenatal-folate-status-with-early-childhood-wheeze-and-atopic-dermatitis
#14
Aditi Roy, Mehmet Kocak, Terryl J Hartman, Shanda Vereen, Margaret Adgent, Chandrika Piyathilake, Frances A Tylavsky, Kecia N Carroll
BACKGROUND: Prenatal folic acid supplementation is recommended to prevent birth defects. Some foods are fortified in the U.S.to ensure sufficient intake among reproductive-aged women. However, high prenatal folate exposure may be a risk factor for childhood atopic diseases. We investigated associations between prenatal folate and early childhood wheeze and atopic dermatitis in a U.S. cohort. METHODS: We studied 858 mother-child dyads, enrolled prenatally. Folate was measured in 2(nd) and 3(rd) trimester maternal plasma...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29168282/risk-factors-for-asthma-occurrence-in-children-with-early-onset-atopic-dermatitis-an-8-year-follow-up-study
#15
Ching-Chun Huang, Tung-Liang Chiang, Pau-Chung Chen, Shio-Jean Lin, Hui-Ju Wen, Yue-Liang Guo
BACKGROUND: Children with early-onset atopic dermatitis (AD) are at substantial risk of developing asthma later in life, and identifying the critical window of detrimental exposure is advantageous for implementing preventive actions. The aim of this study was to evaluate the role of exposure to environmental modifiers during pregnancy and early childhood in asthma occurrence in an infantile AD cohort. METHODS: Eligible study participants were selected from the Taiwan Birth Cohort Study, which enrolled 24200 newborns in 2005...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29168253/genomewide-association-study-of-hla-alloimmunization-in-previously-pregnant-blood-donors
#16
Mark Seielstad, Grier P Page, Nathan Gaddis, Marion Lanteri, Tzong-Hae Lee, Ram Kakaiya, Lisa F Barcellos, Lindsey A Criswell, Darrell Triulzi, Philip J Norris, Michael P Busch
BACKGROUND: Alloimmunization through blood transfusion, transplantation, or circulating fetal cells during pregnancy is a significant concern. Some exposed individuals make alloantibodies while others do not, implying variation in genetic risk factors. STUDY DESIGN AND METHODS: We conducted a genomewide association study (GWAS) of 9,427,497 single-nucleotide polymorphisms (SNPs) to identify genetic variants for HLA alloimmunization in previously pregnant blood donors with (n = 752) and without (n = 753) HLA Class I or II alloantibodies...
November 22, 2017: Transfusion
https://www.readbyqxmd.com/read/29168177/tumor-characteristics-and-prognosis-in-women-with-pregnancy-associated-breast-cancer
#17
Anna L V Johansson, Therese M-L Andersson, Chung-Cheng Hsieh, Karin Jirström, Sven Cnattingius, Irma Fredriksson, Paul W Dickman, Mats Lambe
There is evidence of poor prognosis in women with pregnancy-associated breast cancer (PABC) diagnosed during pregnancy or within two years of delivery. Using a large, population-based cohort, we examined clinicopathologic features and survival in women with PABC. A cohort of women diagnosed with invasive breast cancer between 1992 and 2009 at ages 15 to 44 years was identified in the Swedish Cancer Register and the Breast Cancer Quality Registers. Dates of childbirths for each woman were retrieved from the Swedish Multi-Generation Register...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29168161/a-multilevel-approach-to-breastfeeding-promotion-using-healthy-start-to-deliver-individual-support-and-drive-collective-impact
#18
Chelsey Leruth, Jacqueline Goodman, Brian Bragg, Dara Gray
Purpose Breastfeeding has been linked to a host of positive health effects for women and children. However, disparities in breastfeeding initiation and duration prevent many low-income and African-American women from realizing these benefits. Existing breastfeeding promotion efforts often do not reach women who need support the most. In response, the Westside Healthy Start program (WHS), located in Chicago, Illinois, developed an ongoing multilevel approach to breastfeeding promotion. Description Key elements of our WHS breastfeeding model include individual education and counseling from pregnancy to 6 months postpartum and partnership with a local safety-net hospital to implement the Baby-Friendly Hospital Initiative and provide lactation support to delivering patients...
November 22, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29168113/dynamics-of-bone-marrow-vsels-and-hscs-in-response-to-treatment-with-gonadotropin-and-steroid-hormones-during-pregnancy-and-evidence-to-support-their-asymmetric-symmetric-cell-divisions
#19
Ranita Ganguly, Sidhanath Metkari, Deepa Bhartiya
Gender plays an important role in the incidence of hematological malignancies and recently hematopoietic stem cells (HSCs) were found to proliferate more in females that gets further augmented during pregnancy. It was suggested that since basal numbers of HSCs remain the same in both sexes, possibly HSCs in females undergo increased self-renewal and apoptosis. Then how is self-renewal of stem cells regulated in males? More important, do HSCs undergo asymmetric cell divisions (ACD) or a more primitive population of pluripotent, very small embryonic-like stem cells (VSELs) undergo ACD to self-renew and specify into HSCs? Lot more clarity is required on the bone marrow stem cells biology...
November 22, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29168024/teenage-pregnancy-and-long-term-mental-health-outcomes-among-indigenous-women-in-canada
#20
Chloé G Xavier, Hilary K Brown, Anita C Benoit
Our objectives were to (1) compare the risks for poor long-term mental health outcomes among indigenous women with and without a teenage pregnancy and (2) determine if community and cultural factors modify this risk. We conducted a secondary analysis of the 2012 Aboriginal Peoples Survey. Respondents were women aged 25 to 49 years who had given birth to at least one child. Teenage mothers (age at first birth 13 to 19 years; n = 1330) were compared to adult mothers (age at first birth 20 years or older; n = 2630)...
November 22, 2017: Archives of Women's Mental Health
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