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https://www.readbyqxmd.com/read/28097642/adrenal-cyst-with-both-m%C3%A3-llerian-and-mesothelial-differentiation-a-clinicopathological-and-immunohistochemical-study-with-implications-for-histogenesis
#1
Łukasz Koperski, Benedykt Szczepankiewicz, Paweł Pihowicz, Łukasz Fus, Ewa Wolińska, Barbara Górnicka
True epithelial-lined cysts are rare forms of adrenal cystic lesions, the pathogenesis of which is still not fully understood. In this report we present a case of an adrenal cyst diagnosed incidentally on imaging in a 31-year-old, previously healthy, obese woman. Due to non-specific hormonal disorders and enlargement of the lesion, a right-sided laparoscopic adrenalectomy was performed. The cyst was lined predominantly by ciliated cuboidal-to-columnar, Müllerian-type epithelium, and focally by flat-to-cuboidal, mesothelium-like lining...
January 18, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28072581/-131-i-activity-quantification-of-gamma-camera-planar-images
#2
Raquel Barquero, Hugo P Garcia, Monica G Incio, Pablo Minguez, Alexander Cardenas, Daniel Martínez, Michael Lassmann
A procedure to estimate the activity in target tissues in patients during the therapeutic administration of (131)I radiopharmaceutical treatment for thyroid conditions (hyperthyroidism and differentiated thyroid cancer) using a gamma camera (GC) with a high energy (HE) collimator, is proposed. Planar images are acquired for lesions of different sizes r, and at different distances d, in two HE GC systems. Defining a region of interest (ROI) on the image of size r, total counts n g are measured. Sensitivity S (cps MBq(-1)) in each acquisition is estimated as the product of the geometric G and the intrinsic efficiency η 0...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28066736/joint-preservation-after-hip-arthroscopy-in-patients-with-fai-prospective-analysis-with-a-minimum-follow-up-of-seven-years
#3
Fernando Comba, Carlos Yacuzzi, Pablo J Ali, Gerardo Zanotti, Martin Buttaro, Francisco Piccaluga
BACKGROUND: The purpose of this study is to evaluate the clinical outcomes, radiological degenerative progression and the joint preservation rate in a series of patients with Femoroacetabular Impingement (FAI) treated with hip arthroscopy at a minimum follow-up of 7 years. The predictive factors for total hip arthroplasty (THA) requirement were analyzed. MATERIALS AND METHODS: Between February 2008 and February 2009, 42 consecutive patients treated with hip arthroscopy due to FAI syndrome were included...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28063144/undifferentiated-carcinoma-of-the-ampulla-of-vater
#4
Misuzu Yamada, Daisuke Furukawa, Naoki Yazawa, Hideki Izumi, Yoshihito Masuoka, Taro Mashiko, Yoshiaki Kawaguchi, Masami Ogawa, Yohei Kawashima, Tetsuya Mine, Kenichi Hirabayashi, Toshio Nakagohri
Undifferentiated carcinoma of the ampulla of Vater is a rare disease with unclear and clinical characteristics and prognosis. Here, we report the case of a 61-year-old man with undifferentiated carcinoma of the ampulla of Vater. He presented to our hospital with an increase in hepatobiliary system enzymes that was detected during a health check-up. Imaging and endoscopy demonstrated a tumor with ulcer in the ampulla of Vater, which was diagnosed as a carcinoma by biopsy. No distant metastasis was observed. Subtotal stomach-preserving pancreaticoduodenectomy was performed...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28038707/cystic-and-necrotic-papillary-renal-cell-carcinoma-prognosis-morphology-immunohistochemical-and-molecular-genetic-profile-of-10-cases
#5
Kvetoslava Peckova, Petr Martinek, Kristyna Pivovarcikova, Tomas Vanecek, Reza Alaghehbandan, Kristyna Prochazkova, Delia Perez Montiel, Milan Hora, Faruk Skenderi, Monika Ulamec, Pavla Rotterova, Ondrej Daum, Jiri Ferda, Whitney Davidson, Ondrej Ondic, Magdalena Dubova, Michal Michal, Ondrej Hes
Conflicting data have been published on the prognostic significance of tumor necrosis in papillary renal cell carcinoma (PRCC). Although the presence of necrosis is generally considered an adverse prognostic feature in PRCC, we report a cohort of 10 morphologically distinct cystic and extensively necrotic PRCC with favorable biological behavior. Ten cases of type 1 PRCC with a uniform morphologic pattern were selected from the 19 500 renal tumors, of which 1311 were PRCCs in our registry. We focused on precise morphologic diagnosis supported by immunohistochemical and molecular-genetic analysis...
February 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27787917/quantitative-comparison-of-cortical-bone-thickness-using-correspondence-based-shape-modeling-in-patients-with-cam-femoroacetabular-impingement
#6
Penny R Atkins, Shireen Y Elhabian, Praful Agrawal, Michael D Harris, Ross T Whitaker, Jeffrey A Weiss, Christopher L Peters, Andrew E Anderson
: The proximal femur is abnormally shaped in patients with cam-type femoroacetabular impingement (FAI). Impingement may elicit bone remodeling at the proximal femur, causing increases in cortical bone thickness. We used correspondence-based shape modeling to quantify and compare cortical thickness between cam patients and controls for the location of the cam lesion and the proximal femur. Computed tomography images were segmented for 45 controls and 28 cam-type FAI patients. The segmentations were input to a correspondence-based shape model to identify the region of the cam lesion...
October 27, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27756225/gene-expression-profiling-of-trout-regenerating-muscle-reveals-common-transcriptional-signatures-with-hyperplastic-growth-zones-of-the-post-embryonic-myotome
#7
Jerôme Montfort, Aurelie Le Cam, Jean-Charles Gabillard, Pierre-Yves Rescan
BACKGROUND: Muscle fibre hyperplasia stops in most fish when they reach approximately 50 % of their maximum body length. However, new small-diameter muscle fibres can be produced de novo in aged fish after muscle injury. Given that virtually nothing is known regarding the transcriptional mechanisms that regulate regenerative myogenesis in adult fish, we explored the temporal changes in gene expression during trout muscle regeneration following mechanical crushing. Then, we compared the gene transcription profiles of regenerating muscle with the previously reported gene expression signature associated with muscle fibre hyperplasia...
October 18, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27695906/is-there-a-distinct-pattern-to-the-acetabular-labrum-and-articular-cartilage-damage-in-the-non-dysplastic-hip-with-instability
#8
Kotaro R Shibata, Shuichi Matsuda, Marc R Safran
PURPOSE: The purpose of this study was to determine whether or not there is a distinct pattern of injury to the acetabular labrum and/or cartilage in the hip with instability without bony dysplasia. METHODS: Surgical records and intra-operative images of consecutive patients who underwent primary hip arthroscopy for femoroacetabular impingement (FAI) and/or hip instability by the senior author from April 2007 to December 2014 were retrospectively reviewed. Pathological changes were documented and charted on a novel diagram of the acetabulum, and classified into eight patterns corresponding to the lesion's location and size...
October 1, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27630735/inhibitory-effect-of-valencene-on-the-development-of-atopic-dermatitis-like-skin-lesions-in-nc-nga-mice
#9
In Jun Yang, Dong-Ung Lee, Heung Mook Shin
Valencene (VAL) isolated from Cyperus rotundus possesses various biological effects such as antiallergic and antimelanogenesis activity. We investigated the effect of VAL on atopic dermatitis (AD) skin lesions and their molecular mechanisms. We topically applied VAL to 1-chloro-2,4-dinitrobenzene (DNCB) sensitized NC/Nga mice. Modified scoring atopic dermatitis index, scratching behavior, and histological/immunohistochemical staining were used to monitor disease severity. RT-PCR, western blotting, and enzyme-linked immunosorbent assay were used to determine the level of IgE, proinflammatory cytokines/chemokines production, and skin barrier proteins expression...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27622612/coadministration-of-the-fniii14-peptide-synergistically-augments-the-anti-cancer-activity-of-chemotherapeutic-drugs-by-activating-pro-apoptotic-bim
#10
Takuya Iyoda, Yumi Nagamine, Yoshitomi Nakane, Yuya Tokita, Shougo Akari, Kazuki Otsuka, Motomichi Fujita, Keisuke Itagaki, You-Ichi Takizawa, Hiroaki Orita, Toshiyuki Owaki, Jyunichi Taira, Ryo Hayashi, Hiroaki Kodama, Fumio Fukai
The acquisition of drug resistance mediated by the interaction of tumor cells with the extracellular matrix (ECM), commonly referred to as cell adhesion-mediated drug resistance (CAM-DR), has been observed not only in hematopoietic tumor cells but also in solid tumor cells. We have previously demonstrated that a 22-mer peptide derived from fibronectin, FNIII14, can inhibit cell adhesion through the inactivation of β1 integrin; when coadministered with cytarabine, FNIII14 completely eradicates acute myelogenous leukemia by suppressing CAM-DR...
2016: PloS One
https://www.readbyqxmd.com/read/27590644/what-are-the-results-of-surgical-treatment-of-hip-dysplasia-with-concomitant-cam-deformity
#11
Jens Goronzy, Lea Franken, Albrecht Hartmann, Falk Thielemann, Anne Postler, Tobias Paulus, Klaus-Peter Günther
BACKGROUND: Periacetabular osteotomy (PAO) is a reliable procedure to correct the deficient acetabular coverage in hips with developmental dysplasia. It is unclear how the presence of additional femoral cam-type deformity might influence the clinical and radiographic treatment results of PAO. QUESTIONS/PURPOSES: (1) Are there differences in clinical scores (WOMAC, EQ-5D) and examination findings (impingement sign) or radiographic measures of acetabular orientation and head sphericity after PAO for isolated acetabular dysplasia when compared with the combined pathology of dysplasia and additional femoral cam deformity? (2) Are these clinical and radiographic findings after combined surgical therapy for additional cam deformity influenced by different pathology-adjusted surgical techniques? METHODS: From July 2005 to December 2010, 86 patients (106 hips) underwent PAO for hip dysplasia...
September 2, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27583164/unrecognized-osteoid-osteoma-of-the-proximal-femur-with-associated-cam-impingement
#12
REVIEW
Justin A Ly, Erin M Coleman, Gary S Cohen, Eric J Kropf
Femoro-acetabular impingement is a common cause of hip pain in young athletes. Evaluation typically includes radiographs and magnetic resonance imaging. It is important to appreciate uncommon diagnoses and the role of complimentary imaging. This clinical vignette emphasizes the need complete imaging with CT in select case of atypical hip pain. We present a 19-year old soccer player who underwent seemingly successful arthroscopic FAI surgery but returned with pain. Computed tomography (CT) revealed osteoid osteoma of the lesser trochanter...
August 2016: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/27583150/danish-hip-arthroscopy-registry-an-epidemiologic-and-perioperative-description-of-the-first-2000-procedures
#13
Bjarne Mygind-Klavsen, Torsten Grønbech Nielsen, Niels Maagaard, Otto Kraemer, Per Hölmich, Søren Winge, Bent Lund, Martin Lind
Danish Hip Arthroscopy Registry (DHAR) was initiated in 2012 as a web-based prospective registry. The purpose of this study was to evaluate and report the epidemiologic and perioperative data of the first 2000 procedures in a Danish hip arthroscopy population and to describe the development of DHAR. We describe the use of various Patient Related Outcome Measures related to non-arthritic hip patients. The 2000 procedures consisted of 56% females and 44% males. Mean age 37.5 years, mean surgical time was 86.5 min and mean traction time 50...
July 2016: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/27552292/geographic-atrophy-semantic-considerations-and-literature-review
#14
Steffen Schmitz-Valckenberg, Srinivas Sadda, Giovanni Staurenghi, Emily Y Chew, Monika Fleckenstein, Frank G Holz
PURPOSE: There is a lack of agreement regarding the types of lesions and clinical conditions that should be included in the term "geographic atrophy." Varied and conflicting views prevail throughout the literature and are currently used by retinal experts and other health care professionals. METHODS: We reviewed the nominal definition of the term "geographic atrophy" and conducted a search of the ophthalmologic literature focusing on preceding terminologies and the first citations of the term "geographic atrophy" secondary to age-related macular degeneration...
December 2016: Retina
https://www.readbyqxmd.com/read/27501938/use-of-complementary-health-approaches-at-military-treatment-facilities-active-component-u-s-armed-forces-2010-2015
#15
Valerie F Williams, Leslie L Clark, Mark G McNellis
Survey-based research has demonstrated the increasing use and acceptance of complementary and alternative medicine (CAM) in general and military populations. This report summarizes the use of three CAM procedures (chiropractic/osteopathic manipulation, acupuncture, and biofeedback) among active component service members from 2010 through 2015. Findings document a marked increase in the use of chiropractic/osteopathic manipulation and acupuncture procedures since 2010. The majority of the 240 military installations in this analysis provided chiropractic/osteopathic manipulation; more than three-quarters provided acupuncture; and approximately one-third provided biofeedback procedures...
July 2016: MSMR
https://www.readbyqxmd.com/read/27495863/editorial-commentary-risk-factors-for-chondral-lesions-in-the-hip-there-is-more-to-it-than-cam-and-pincer
#16
EDITORIAL
Erik Hohmann
Age has been cited in a recent article as the largest predictor of both chondral and labral lesions in patients with hip dysplasia. But it was not surprising that there is also a direct relation between a small lateral center-edge angle, acetabular head index, and cartilage degeneration and an increased acetabular index and labral tears in patients with hip dysplasia. The severity of the congenital disease determines the severity of the intra-articular lesions.
August 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27471802/cad-cam-endocrown-fabrication-from-a-polymer-infiltrated-ceramic-network-block-for-primary-molar-a-case-report
#17
Mehmet Selim Bilgin, Ali Erdem, Mehmet Tanrıver
OBJECTIVE: The aim of this case report is to describe the treatment of a primary molar with a deep carious lesion by pulpotomy and placement of a ceramic endocrown. CLINICAL CASE: A 7-year-old male patient with profound caries in tooth number 85 was referred to our clinic and underwent a pulpotomy. As the final treatment in tooth restoration, placement of an endocrown was planned, because little more than half of the tooth structure remained. After an additional request from the patient's parents for an advanced and prompt restoration, a computer-aided design/computer-aided manufacturing (CAD/CAM) polymer-infiltrated ceramic network (PICN) block was chosen...
2016: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27466223/analysis-of-the-current-indications-for-microfracture-of-chondral-lesions-in-the-hip-joint
#18
Darrin J Trask, James S Keene
BACKGROUND: Data on the efficacy of microfracture for treatment of chondral defects in the hip are currently limited, and the recommended criteria for its use (minimal osteoarthritis; a focal, contained lesion <4 cm(2) in size) have been taken from those that were established for the knee. PURPOSE: To determine if the current microfracture (ie, knee) criteria are appropriate for chondral lesions in the hip. STUDY DESIGN: Case series; Level of evidence, 4...
December 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27446275/electroacupuncture-improves-cognitive-ability-following-cerebral-ischemia-reperfusion-injury-via-cam-camkiv-creb-signaling-in-the-rat-hippocampus
#19
Yun Zhang, Ruhui Lin, Jing Tao, Yunan Wu, Bin Chen, Kunqiang Yu, Jixiang Chen, Xiaojie Li, Li-Dian Chen
The aim of the present study was to investigate the effect of electroacupuncture (EA) on cognitive deficits, and the underlying mechanism following cerebral ischemia-reperfusion (I/R) via the calmodulin (CaM)-calmodulin-dependent protein kinase type IV (CaMKIV)-cyclic adenosine monophosphate response elements binding protein (CREB) intracellular signaling pathway in the hippocampus. In total, 45 adult female Sprague-Dawley rats were randomly divided into three groups, namely the sham group, the middle cerebral artery occlusion (MCAO) group and the MCAO + EA group...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27431333/slow-erosion-of-a-quantitative-apple-resistance-to-venturia-inaequalis-based-on-an-isolate-specific-quantitative-trait-locus
#20
Valérie Caffier, Bruno Le Cam, Mehdi Al Rifaï, Marie-Noëlle Bellanger, Morgane Comby, Caroline Denancé, Frédérique Didelot, Pascale Expert, Tifenn Kerdraon, Arnaud Lemarquand, Elisa Ravon, Charles-Eric Durel
Quantitative plant resistance affects the aggressiveness of pathogens and is usually considered more durable than qualitative resistance. However, the efficiency of a quantitative resistance based on an isolate-specific Quantitative Trait Locus (QTL) is expected to decrease over time due to the selection of isolates with a high level of aggressiveness on resistant plants. To test this hypothesis, we surveyed scab incidence over an eight-year period in an orchard planted with susceptible and quantitatively resistant apple genotypes...
October 2016: Infection, Genetics and Evolution
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