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meningococcal b vaccine

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https://www.readbyqxmd.com/read/28931535/risk-of-hospitalisation-with-fever-following-menb-vaccination-self-controlled-case-series-analysis
#1
Heather Murdoch, Lynn Wallace, Jennifer Bishop, Chris Robertson, J Claire Cameron
OBJECTIVE: To investigate a possible association between fever admissions and 4 component Meningococcal B (4CMenB). DESIGN: 4CMenB is given at 8 and 16 weeks in the first year of life. Self-controlled case series using linked routinely collected healthcare data, where the risk period was the 3 days immediately following receipt of a vaccine dose. PATIENTS: Children aged under 1 year in Scotland preintroduction and postintroduction of 4CMenB vaccine (pre-September 2014 to August 2015 and post-September 2015 to June 2016)...
October 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28931534/the-yin-and-yang-of-fever-after-meningococcal-b-vaccination
#2
EDITORIAL
Shamez N Ladhani, Andrew Riordan
No abstract text is available yet for this article.
October 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28931058/molecular-characterization-of-neisseria-meningitidis-isolates-recovered-from-11-19-year-old-meningococcal-carriers-in-salvador-brazil
#3
Ana Rafaela Silva Simões Moura, Cécilia Batmalle Kretz, Italo Eustáquio Ferreira, Amélia Maria Pithon Borges Nunes, José Cássio de Moraes, Mitermayer Galvão Reis, Alan John Alexander McBride, Xin Wang, Leila Carvalho Campos
Characterization of meningococci isolated from the pharynx is essential towards understanding the dynamics of meningococcal carriage and disease. Meningococcal isolates, collected from adolescents resident in Salvador, Brazil during 2014, were characterized by multilocus sequence typing, genotyping or whole-genome sequencing. Most were nongroupable (61.0%), followed by genogroups B (11.9%) and Y (8.5%). We identified 34 different sequence types (STs), eight were new STs, distributed among 14 clonal complexes (cc), cc1136 represented 20...
2017: PloS One
https://www.readbyqxmd.com/read/28903515/update-from-the-advisory-committee-on-immunization-practices
#4
Sean T O'Leary, Yvonne A Maldonado, Carrie L Byington
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (C...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28882444/tetanus-toxoid-carrier-protein-induced-t-helper-cell-responses-upon-vaccination-of-middle-aged-adults
#5
Marieke van der Heiden, Aafke Duizendstra, Guy A M Berbers, Annemieke M H Boots, Anne-Marie Buisman
INTRODUCTION: Vaccines frequently induce suboptimal immune responses in the elderly, due to immunological ageing. Timely vaccination may be a strategy to overcome this problem, which classifies middle-aged adults asan interesting target group for future vaccine interventions. However, the immunological fitness of the middle-aged population is ill-defined. It is currently unknown whether effective T-cell help towards B-cells is initiated by conjugate-carrier vaccines at middle-age. AIM: We characterized systemic Tetanus Toxoid (TT) specific T-helper cell responses in the circulation of middle-aged adults (50-65years of age, n=31) having received the MenACWY-TT vaccination...
September 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28864711/meningococcal-b-vaccine-failure-with-a-penicillin-resistant-strain-in-a-young-adult-on-long-term-eculizumab
#6
Sydel R Parikh, Jay Lucidarme, Coralie Bingham, Paul Warwicker, Tim Goodship, Ray Borrow, Shamez N Ladhani
We describe a case of invasive meningococcal disease due to a vaccine-preventable and penicillin-resistant strain in a fully immunized young adult on long-term complement inhibitor therapy and daily penicillin chemoprophylaxis. Eculizumab is a humanized monoclonal antibody that binds human complement C5 protein and inhibits the terminal complement pathway. It is currently recommended for the treatment of complement-mediated thrombotic microangiopathies. An unwanted complication of inhibiting complement, however, is an increased risk of invasive meningococcal disease...
September 2017: Pediatrics
https://www.readbyqxmd.com/read/28855159/non-specific-effects-of-measles-mumps-and-rubella-mmr-vaccination-in-high-income-setting-population-based-cohort-study-in-the-netherlands
#7
COMPARATIVE STUDY
Susanne M A J Tielemans, Hester E de Melker, Susan J M Hahné, Anna G C Boef, Fiona R M van der Klis, Elisabeth A M Sanders, Marianne A B van der Sande, Mirjam J Knol
Objectives To investigate whether measles, mumps, and rubella (MMR) vaccine has positive non-specific effects in a high income setting and to compare rates of hospital admissions for infections between children aged ≤2 years who received live MMR vaccine and those who received an inactivated vaccine against diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae type b (DTaP-IPV-Hib) as their most recent vaccination.Design Nationwide population based cohort study.Setting In the Netherlands, DTaP-IPV-Hib+pneumococcal vaccination (PCV) is recommended at ages 2, 3, 4, and 11 months and MMR + meningococcal C (MenC) vaccination at age 14 months...
August 30, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28853975/impact-of-a-web-site-based-educational-programme-for-increasing-vaccination-coverage-among-adolescents
#8
Susanna Esposito, Sonia Bianchini, Claudia Tagliabue, Giulia Umbrello, Barbara Madini, Giada Di Pietro, Nicola Principi
Data regarding the use of technology to improve adolescent knowledge on vaccines are scarce. The main aim of this study was to evaluate whether different web-based educational programmes for adolescents might increase their vaccination coverage. Overall, 917 unvaccinated adolescents (389 males, 42.4%; mean age ± standard deviation, 14.0 ± 2.2 years) were randomized 1:1:1 into the following groups: no intervention (n = 334), website educational programme only (n = 281), or web-site plus face to face lesson (n = 302) groups...
August 30, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28837546/national-regional-state-and-selected-local-area-vaccination-coverage-among-adolescents-aged-13-17-years-united-states-2016
#9
Tanja Y Walker, Laurie D Elam-Evans, James A Singleton, David Yankey, Lauri E Markowitz, Benjamin Fredua, Charnetta L Williams, Sarah A Meyer, Shannon Stokley
The Advisory Committee on Immunization Practices (ACIP) recommends that adolescents routinely receive tetanus, diphtheria, and acellular pertussis vaccine (Tdap), meningococcal conjugate vaccine (MenACWY), and human papillomavirus (HPV) vaccine (1) at age 11-12 years. ACIP also recommends catch-up vaccination with hepatitis B vaccine, measles, mumps, and rubella (MMR) vaccine, and varicella vaccine for adolescents who are not up to date with childhood vaccinations. ACIP recommends a booster dose of MenACWY at age 16 years (1)...
August 25, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28802678/gonococcal-vaccine-development-lessons-from-group-b-meningococcal-vaccines
#10
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28794096/an-increase-in-accident-and-emergency-presentations-for-adverse-events-following-immunisation-after-introduction-of-the-group-b-meningococcal-vaccine-an-observational-study
#11
Viveka Nainani, Ushma Galal, Jim Buttery, Matthew D Snape
OBJECTIVES: To determine whether the introduction of the capsular group B meningococcal vaccine (4CMenB) in the UK has increased presentations of infants to emergency departments with adverse events following immunisation (AEFI). PARTICIPANTS, DESIGN AND SETTING: A retrospective review of hospital records of infants aged 1-6 months presenting to Oxford University Hospitals NHS Trust's emergency departments from September 2013 to August 2016 with discharge diagnoses of vaccine reactions or non-specific conditions...
August 9, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28794055/effect-of-vaccine-elicited-antibodies-on-colonization-of-neisseria-meningitidis-serogroup-b-and-c-strains-in-a-human-bronchial-epithelial-cell-culture-model
#12
Vianca Vianzon, Beate Illek, Gregory R Moe
Capsular polysaccharide-protein conjugate vaccines protect individuals from invasive disease and decrease carriage, which reduces spread of the organism in the population. In contrast, antibodies elicited by plain polysaccharide or protein antigen-based meningococcal (Men) vaccines have little or no effect on decreasing carriage. In this study, we investigated the mechanism by which vaccine-induced human IgG antibodies affect colonization by serogroup B (MenB) or C (MenC) strains using a human bronchial epithelial cell culture model (16HBE14o-)...
August 9, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28770496/serogroup-b-meningococcus-outbreaks-prevalence-and-the-case-for-standard-vaccination
#13
REVIEW
James Grogan, Karen Roos
PURPOSE OF REVIEW: This review explores the history of serogroup B meningitis outbreaks in American universities and the rise of the monovalent serogroup B meningococcus vaccines (MenB). RECENT FINDINGS: Serogroup B meningitis represents 30% of American meningococcal infections and had no commercially available vaccine in the USA until 2013 when the FDA made an expanded allowance for importation of the MenB-4C vaccine for outbreaks at two American universities. Infections of Neisseria meningitidis, notably meningococcal meningitis represent a continued, lethal threat to the pediatric and adolescent populations and those with primary or acquired complement component deficiencies, largely mitigated by the quadrivalent meningococcal conjugated vaccine against serogroups A, C, W, and Y (MenACWY)...
September 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28760611/chronically-ill-adolescents-are-also-incompletely-vaccinated-a-cross-sectional-study-in-france
#14
Christèle Gras-Le Guen, Arnaud Legrand, Marylène Caquard, Xavier Micaelli, Georges Picherot, Sylvie Lacroix, Christelle Volteau, Elise Launay
BACKGROUND: Adolescent vaccination coverage tends to be suboptimal, leading to resurgent infectious pathologies and vulnerability to various pathogens. The low frequency of medical consultations and missed opportunities for vaccination are often used to explain the low rate of vaccination. The aim of this study was to assess if the vaccination coverage rate is higher in chronically ill adolescents (CIA) who require a close pediatric specialized follow-up versus the rate in healthy adolescents (HA)...
July 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28739825/neisseria-cinerea-expresses-a-functional-factor-h-binding-protein-which-is-recognised-by-immune-responses-elicited-by-meningococcal-vaccines
#15
Hayley Lavender, Katy Poncin, Christoph M Tang
Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W and Y. More recently two protein based vaccines, Bexsero® and Trumenba®, have been licenced against meningococcal serogroup B strains; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface exposed lipoprotein which binds the negative complement regulator, complement factor H (CFH), thereby inhibiting the alternative pathway of complement activation...
July 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28737301/vaccine-preventable-admissions-to-an-irish-paediatric-intensive-care
#16
Y Doyle, M Healy, C McMahon, S Crowe
In the Republic of Ireland, the schedule of state-funded immunisation for children is comprehensive and includes diphtheria, pertussis, tetanus, pneumococcus, hepatitis B, meningococcus C, haemophilus B, polio, measles, rubella and mumps. Varicella and meningococcal B vaccines are commercially available but are not currently funded by the government. Each of the illnesses preventable by these vaccines can cause substantial morbidity, and rarely mortality, in infants and children. Our PICU continues to see serious illness due to avoidable infection...
May 10, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28729920/annual-vaccine-preventable-disease-report-for-new-south-wales-australia-2014
#17
Nathan Saul, Robin Gilmour, Paula Spokes
This report provides an epidemiological description of selected vaccine-preventable diseases in New South Wales (NSW), Australia, for 2014 to inform ongoing disease monitoring and control efforts. A trend of increasing pertussis notifications was observed, beginning midway through 2014 with the highest disease rates in the 5-9 year age group. Measles notifications increased to 67 cases in 2014 from 34 cases in 2013. Measles cases were associated with travel-related importations-predominantly from the Philippines-and secondary transmission increased compared to 2013 involving three main disease clusters...
April 2017: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/28705462/effectiveness-of-a-group-b-outer-membrane-vesicle-meningococcal-vaccine-against-gonorrhoea-in-new-zealand-a-retrospective-case-control-study
#18
Helen Petousis-Harris, Janine Paynter, Jane Morgan, Peter Saxton, Barbara McArdle, Felicity Goodyear-Smith, Steven Black
BACKGROUND: Gonorrhoea is a major global public health problem that is exacerbated by drug resistance. Effective vaccine development has been unsuccessful, but surveillance data suggest that outer membrane vesicle meningococcal group B vaccines affect the incidence of gonorrhoea. We assessed vaccine effectiveness of the outer membrane vesicle meningococcal B vaccine (MeNZB) against gonorrhoea in young adults aged 15-30 years in New Zealand. METHODS: We did a retrospective case-control study of patients at sexual health clinics aged 15-30 years who were born between Jan 1, 1984, and Dec 31, 1998, eligible to receive MeNZB, and diagnosed with gonorrhoea or chlamydia, or both...
July 7, 2017: Lancet
https://www.readbyqxmd.com/read/28698183/meningococcal-b-vaccination-also-cuts-risk-of-gonorrhoea-study-suggests
#19
Susan Mayor
No abstract text is available yet for this article.
July 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28668575/meningococcal-serogroup-c-immunogenicity-antibody-persistence-and-memory-b-cells-induced-by-the-monovalent-meningococcal-serogroup-c-versus-quadrivalent-meningococcal-serogroup-acwy-conjugate-booster-vaccine-a-randomized-controlled-trial
#20
Mariëtte B van Ravenhorst, Fiona R M van der Klis, Debbie M van Rooijen, Mirjam J Knol, Susanne P Stoof, Elisabeth A M Sanders, Guy A M Berbers
BACKGROUND: Adolescents are considered the key transmitters of meningococci in the population. Meningococcal serogroup C (MenC) antibody levels wane rapidly after MenC conjugate vaccination in young children, leaving adolescents with low antibody levels. In this study, we compared MenC immune responses after booster vaccination in adolescence with either tetanus toxoid conjugated MenC (MenC-TT) or MenACWY (MenACWY-TT) vaccine, and aimed to establish an optimal age for this booster. METHODS: Healthy 10-, 12-, and 15-year-olds, who received a single dose of MenC-TT vaccine in early childhood, were randomized to receive MenC-TT or MenACWY-TT vaccine...
June 28, 2017: Vaccine
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