Nicolas Jacquelot, Le Xiong, Wang H J Cao, Qiutong Huang, Huiyang Yu, Azin Sayad, Casey J A Anttila, Tracey M Baldwin, Peter F Hickey, Daniela Amann-Zalcenstein, Pamela S Ohashi, Stephen L Nutt, Gabrielle T Belz, Cyril Seillet
Interleukin-(IL) 22 production by intestinal group 3 innate lymphoid cells (ILC3) is critical to maintain gut homeostasis. However, IL-22 needs to be tightly controlled; reduced IL-22 expression is associated with intestinal epithelial barrier defect while its overexpression promotes tumor development. Here, using a single cell RNAseq approach, we identified a core set of genes associated with increased IL-22 production by ILC3. Among these genes, Programmed cell death 1 (PD-1), extensively studied in the context of cancer and chronic infection, was constitutively expressed on a subset of ILC3...
March 14, 2024: Mucosal Immunology