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https://www.readbyqxmd.com/read/28638303/the-use-of-gabapentin-for-pain-and-agitation-in-neonates-and-infants-in-a-neonatal-icu
#1
Gretchen L Sacha, Maria G Foreman, Kay Kyllonen, Ricardo J Rodriguez
OBJECTIVES: Limited data support how to safely and effectively treat refractory pain and agitation in neonates and infants. Gabapentin has been used in this patient population and has shown promising results, yet there is still a paucity of data about its clinical efficacy. There is a need for a larger evaluation to determine its effectiveness. This study describes one institution's experience with gabapentin for the treatment of refractory pain and agitation in the neonatal intensive care unit (NICU)...
May 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28636421/analysis-of-origins-of-admission-for-solid-tumor-oncology-inpatients-disease-severity-and-outcomes
#2
Christopher E Wee, Lindsey M Goodman, Leticia Varella, Lisa A Rybicki, Alberto J Montero, Bassam N Estfan, Carolyn H Best, James P Stevenson
PURPOSE: Hospital transfers may affect clinical outcomes. Evaluation of admission by source of transfer, time of admission, and provider type may identify opportunities to improve inpatient outcomes. METHODS: We reviewed charts of patients admitted to the solid tumor oncology service between July and December 2014 from the Cleveland Clinic Foundation (CCF) Main Campus emergency department (ED), CCF Regional EDs, outside hospital (OSH) ED, OSH inpatient services, and CCF outpatient clinics...
June 21, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28633225/patient-specific-simulation-of-endovascular-thoracic-aortic-repair-initial-experience
#3
Liesbeth M Desender, Isabelle Van Herzeele, Zoran Rancic, Colin Bicknell, Ignatios Zairis, Frank E Vermassen, John H Rundback
PURPOSE: Endovascular thoracic aortic repair (TEVAR) has become the treatment modality of diverse aortic pathology. We report the use of patient-specific simulation using a dedicated PROcedure Rehearsal Studio (PRS) platform (Simbionix USA Corp, Cleveland, OH) before TEVAR and evaluate the feasibility and realism of this technology. DESCRIPTION: Virtual three-dimensional models of the patient's relevant anatomy were reconstructed from computed tomography data. PRS was used in 2 patients before TEVAR...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28631827/one-year-results-of-the-scandiv-randomized-clinical-trial-of-laparoscopic-lavage-versus-primary-resection-for-acute-perforated-diverticulitis
#4
J K Schultz, C Wallon, L Blecic, H M Forsmo, J Folkesson, P Buchwald, H Kørner, F A Dahl, T Øresland, S Yaqub
BACKGROUND: Recent randomized trials demonstrated that laparoscopic lavage compared with resection for Hinchey III perforated diverticulitis was associated with similar mortality, less stoma formation but a higher rate of early reintervention. The aim of this study was to compare 1-year outcomes in patients who participated in the randomized Scandinavian Diverticulitis (SCANDIV) trial. METHODS: Between February 2010 and June 2014, patients from 21 hospitals in Norway and Sweden presenting with suspected perforated diverticulitis were enrolled in a multicentre RCT comparing laparoscopic lavage and sigmoid resection...
June 20, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28630049/comparison-of-electroacupuncture-and-medical-treatment-for-functional-constipation-a-systematic-review-and-meta-analysis
#5
Sheng-Li Zhou, Xiu-Lai Zhang, Jing-Hua Wang
OBJECTIVES: To assess the effectiveness of electroacupuncture (EA) relative to conventional medication in functional constipation (FC). DESIGN: Systematic review and meta-analysis SETTING: To be included, studies needed to: (1) have been randomised controlled trials; (2) have recruited adult patients diagnosed with FC according to the Rome II/III criteria or the American Gastroenterological Association guideline for chronic FC; and (3) have randomised patients to be treated with EA or anti-constipation medication...
June 19, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28620573/clinical-characteristics-and-outcomes-of-patients-with-ischemic-and-non-ischemic-complete-heart-block
#6
Murtaza Sundhu, Mehmet Yildiz, Mubbasher Syed, Bhavan Shah, Sajjad Gul, Omer Afzal, Lon Castle
INTRODUCTION: Third degree or complete heart block (CHB) is a medical emergency and usually requires permanent pacemaker placement. CHB can be caused by cardiac ischemia or non-ischemic conditions such as infiltrative diseases or fibrosis. The purpose of this study is to identify the baseline clinical characteristics associated with ischemic versus non-ischemic causes of complete heart block and compare their outcomes. MATERIALS AND METHODS: An institutional review broad approval was granted by the Cleveland Clinic Health System...
May 12, 2017: Curēus
https://www.readbyqxmd.com/read/28616442/human-coronavirus-hku1-infection-among-adults-in-cleveland-ohio
#7
Anubhav Kanwar, Suresh Selvaraju, Frank Esper
BACKGROUND: Human coronaviruses (CoV) have been long recognized as a common cause of respiratory tract disease including severe respiratory tract illness. Coronavirus-HKU1 has been described predominantly among children less than 5 years of age in the United States with few studies characterizing the disease spectrum among adults. METHODS: Nasopharyngeal specimens of patients with respiratory symptoms were analyzed for CoV-HKU1 by NxTAG Respiratory Pathogen Panel multiplex assay from February 7, 2016 to April 30, 2016...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28614683/single-nephron-glomerular-filtration-rate-in-healthy-adults
#8
Aleksandar Denic, Jerry Mathew, Lilach O Lerman, John C Lieske, Joseph J Larson, Mariam P Alexander, Emilio Poggio, Richard J Glassock, Andrew D Rule
BACKGROUND: The glomerular filtration rate (GFR) assesses the function of all nephrons, and the single-nephron GFR assesses the function of individual nephrons. How the single-nephron GFR relates to demographic and clinical characteristics and kidney-biopsy findings in humans is unknown. METHODS: We identified 1388 living kidney donors at the Mayo Clinic and the Cleveland Clinic who underwent a computed tomographic (CT) scan of the kidney with the use of contrast material and an iothalamate-based measurement of the GFR during donor evaluation and who underwent a kidney biopsy at donation...
June 15, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28612386/impact-of-comorbidities-on-outcomes-of-elderly-patients-with-diffuse-large-b-cell-lymphoma
#9
Caner Saygin, Xuefei Jia, Brian Hill, Robert Dean, Brad Pohlman, Mitchell R Smith, Deepa Jagadeesh
International prognostic index (IPI) has remained the primary prognostic tool in diffuse large B cell lymphoma (DLBCL) for more than 20 years. Even though the disease is more common in older population, the impact of comorbidities, dose reductions, and treatment-related adverse events (TAEs) on the outcome in elderly DLBCL patients has not been well established. We studied 413 consecutive patients aged ≥ 60 years who were treated at the Cleveland Clinic. The median age at diagnosis was 69 years, 58% of patients had high IPI score, and 85% had low Charlson comorbidity index (CCI)...
June 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28611838/endovascular-embolization-of-intracranial-infectious-aneurysms-in-patients-undergoing-open-heart-surgery-using-n-butyl-cyanoacrylate
#10
Esteban Cheng-Ching, Seby John, Mark Bain, Gabor Toth, Thomas Masaryk, Ferdinand Hui, Muhammad Shazam Hussain
INTRODUCTION: Mycotic aneurysms are a serious complication of infective endocarditis with increased risk of intracranial hemorrhage. Patients undergoing open heart surgery for valve repair or replacement are exposed to anticoagulants, increasing the risk of aneurysm bleeding. These patients may require endovascular or surgical aneurysm treatment prior to heart surgery, but data on this approach are scarce. METHODS: Retrospective review of consecutive patients with infectious endocarditis and mycotic aneurysms treated endovascularly with Trufill n-butyl cyanoacrylate (n-BCA) at the Cleveland Clinic between January 2013 and December 2015...
March 2017: Interventional Neurology
https://www.readbyqxmd.com/read/28610832/comparison-of-antimicrobial-activity-between-ceftolozane-tazobactam-and-ceftazidime-avibactam-against-multidrug-resistant-isolates-of-escherichia-coli-klebsiella-pneumoniae-and-pseudomonas-aeruginosa
#11
Adnan Alatoom, Hashim Elsayed, Karen Lawlor, Laila AbdelWareth, Rania El-Lababidi, Lysettee Cardona, Mohammad Mooty, Maria-Fernanda Bonilla, Ahmad Nusair, Imran Mirza
OBJECTIVE: We compared the activity of ceftolozane-tazobactam and ceftazidime-avibactam against 120 strains including extended spectrum β-lactamase (ESBL) producers, carbapenem-resistant Enterobacteriaceae (CRE) and Pseudomonas aeruginosa isolated from patients admitted to Cleveland Clinic Abu Dhabi, United Arab Emirates. METHODS: The in-vitro susceptibility was tested using E-strip MIC method and PCR was used to characterize the carbapenemase enzymes produced by CRE strains...
June 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28607153/2017-acc-aha-hfsa-ishlt-acp-advanced-training-statement-on-advanced-heart-failure-and-transplant-cardiology-revision-of-the-accf-aha-acp-hfsa-ishlt-2010-clinical-competence-statement-on-management-of-patients-with-advanced-heart-failure-and-cardiac-transplant
#12
REVIEW
Mariell Jessup, Mark H Drazner, Wendy Book, Joseph C Cleveland, Ira Dauber, Susan Farkas, Mahazarin Ginwalla, Jason N Katz, Peggy Kirkwood, Michelle M Kittleson, Joseph E Marine, Paul Mather, Alanna A Morris, Donna M Polk, Antoine Sakr, Kelly H Schlendorf, Esther E Vorovich
No abstract text is available yet for this article.
June 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28603057/prevalence-of-eosinophilic-gastroenteritis-and-colitis-in-a-population-based-study-from-2012-to-2017
#13
Emad Mansoor, Mohannad Abou Saleh, Gregory S Cooper
BACKGROUND & AIMS: Although eosinophilic esophagitis (EoE) has been extensively studied, there have been few epidemiology studies of other eosinophilic gastrointestinal disorders (EGIDs). Using a large, population-based database, we investigated epidemiologic features of eosinophilic gastroenteritis (EoGE), and colitis (EoC) in the United States (US). METHODS: We collected data from a commercial database (Explorys Inc, Cleveland, OH) that provided electronic health records from 26 major integrated US healthcare systems from 1999 to March 2017...
June 8, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28566888/risk-of-progression-of-barrett-s-esophagus-in-patients-with-cirrhosis
#14
Tehilla Apfel, Rocio Lopez, Madhusudhan R Sanaka, Prashanthi N Thota
AIM: To study Barrett's esophagus (BE) in cirrhosis and assess progression to esophageal adenocarcinoma (EAC) compared to non-cirrhotic BE controls. METHODS: Cirrhotic patients who were found to have endoscopic evidence of BE confirmed by the presence of intestinal metaplasia on histology from 1/1/2000 to 12/1/2015 at Cleveland Clinic were included. Cirrhotic patients were matched 1:4 to BE controls without cirrhosis. Age, gender, race, BE length, hiatal hernia size, Child-Pugh (CP) class and histological findings were recorded...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28556385/atenolol-versus-propranolol-for-treatment-of-infantile-hemangiomas-during-the-proliferative-phase-a-retrospective-noninferiority-study
#15
Cheryl B Bayart, Joan E Tamburro, Allison T Vidimos, Lu Wang, Alex B Golden
BACKGROUND/OBJECTIVES: The nonselective beta-blocker propranolol is the current criterion standard for treatment of infantile hemangiomas (IHs) and the first therapy that the U.S. Food and Drug Administration has approved for the condition, but concern about adverse effects, such as bronchospasm, hypoglycemia, and sleep disturbances, has sparked interest in the use of alternative agents such as the selective β1 antagonist atenolol. Our aim was to compare the efficacy and adverse effect profiles of atenolol with those of propranolol in the treatment of IHs in a retrospective noninferiority trial...
May 28, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28546007/development-and-validation-of-the-halt-hcc-score-to-predict-mortality-in-liver-transplant-recipients-with-hepatocellular-carcinoma-a-retrospective-cohort-analysis
#16
Kazunari Sasaki, Daniel J Firl, Koji Hashimoto, Masato Fujiki, Teresa Diago-Uso, Cristiano Quintini, Bijan Eghtesad, John J Fung, Federico N Aucejo, Charles M Miller
BACKGROUND: Tumour morphological criteria for determining the appropriateness of liver transplantation in patients with hepatocellular carcinoma poorly estimate post-transplantation mortality. The aim of this study was to develop and assess the utility of a continuous risk score in predicting overall survival following liver transplantation for hepatocellular carcinoma. METHODS: We did a retrospective cohort analysis to develop a continuous multivariable risk score for assessment of overall survival following liver transplantation for hepatocellular carcinoma...
May 22, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28544989/impact-of-mediolateral-episiotomy-on-incidence-of-obstetrical-anal-sphincter-injury-diagnosed-by-endoanal-ultrasound
#17
Kristina Drusany Staric, Adolf Lukanovic, Petra Petrocnik, Vita Zacesta, Corrado Cescon, Miha Lucovnik
OBJECTIVE: to examine potential association between mediolateral episiotomy and reduced incidence of obstetrical anal sphincter injuries (OASIS) diagnosed by endoanal ultrasound. DESIGN: prospective cohort study. SETTING: tertiary referral university hospital. PARTICIPANTS: sixty nulliparous women at 28-33 weeks of gestation with singleton pregnancies were included between 2010 and 2012. MEASUREMENTS AND FINDINGS: participants were examined with endoanal ultrasound at 28-33 weeks gestation and at 6-7 weeks post-partum...
May 18, 2017: Midwifery
https://www.readbyqxmd.com/read/28529185/care-2013-explanations-and-elaborations-reporting-guidelines-for-case-reports
#18
David S Riley, Melissa S Barber, Gunver S Kienle, Jeffry Aronson, Tido von Schoen-Angerer, Peter Tugwell, Helmut Kiene, Mark Helfand, Douglas G Altman, Harold Sox, Paul G Werthmann, David Moher, Richard A Rison, Larissa Shamseer, Christian A Koch, Gordon H Sun, Patrick Hanaway, Cleveland Clinic, Nancy L Sudak, Marietta Kaszkin-Bettag, Joel J Gagnier
Well-written and transparent case reports (1) reveal early signals of potential benefits, harms, and information on the use of resources; (2) provide information for clinical research and clinical practice guidelines (CPGs), and (3) inform medical education. High-quality case reports are more likely when authors follow reporting guidelines. During 2011-2012 a group of clinicians, researchers, and journal editors developed recommendations for the accurate reporting of information in case reports that resulted in the CARE (CAse REport) Statement and Checklist...
May 18, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28527232/three-dimensional-evaluation-of%C3%A2-postural%C3%A2-stability-in-parkinson-s-disease-with-mobile-technology
#19
Sarah J Ozinga, Mandy Miller Koop, Susan M Linder, Andre G Machado, Tanujit Dey, Jay L Alberts
BACKGROUND: Postural instability is a hallmark of Parkinson's disease. Objective metrics to characterize postural stability are necessary for the development of treatment algorithms to aid in the clinical setting. OBJECTIVE: The aim of this project was to validate a mobile device platform and resultant three-dimensional balance metric that characterizes postural stability. METHODS: A mobile Application was developed, in which biomechanical data from inertial sensors within a mobile device were processed to characterize movement of center of mass in the medial-lateral, anterior-posterior and trunk rotation directions...
May 13, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28485495/locoregional-recurrence-following-maxillectomy-implications-for-microvascular-reconstruction
#20
Ilya Likhterov, Michael A Fritz, Ivan H El-Sayed, Rahul Seth, Hani M Rayess, P Daniel Knott
OBJECTIVE: Reconstruction of maxillectomy defects offers potential quality-of-life improvement, although cavity coverage may impact surveillance of recurrent malignancy. We describe the pattern of postmaxillectomy locoregional recurrence. STUDY DESIGN: Retrospective review. METHODS: Patients from 2001 to 2011 at the University of California, San Francisco and the Cleveland Clinic. RESULTS: Among 75 patients with malignancy resulting in partial or total maxillectomy, 57 were treated with obturators and 18 underwent reconstructive surgery...
May 9, 2017: Laryngoscope
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