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https://www.readbyqxmd.com/read/28929717/-thunderstorm-and-asthma-outbreaks-during-pollen-season
#1
Maria D'Amato, Isabella Annesi-Maesano, Antonio Molino, Mauro Mormile, Carolina Vitale, Alessandro Vatrella, Alessandro Sanduzzi, Gennaro D'Amato
An increasing body of evidence shows the occurrence of asthma epidemics, sometimes also severe, during thunderstorms in the pollen season in various geographical zones. The main hypothesis explaining association between thunderstorms and asthma claims that thunderstorms can concentrate pollen grains at ground level; these grains may then release allergenic particles of respirable size in the atmosphere after their rupture by osmotic shock. During the first 20-30 minutes of a thunderstorm, patients suffering from pollen allergy may inhale a high concentration of the allergenic material dispersed into the atmosphere, which can, in turn, induce asthmatic reactions, often severe...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28924110/bloody-bronchial-cast-formation-due-to-alveolar-hemorrhage-associated-with-h1n1-influenza-infection
#2
Yohei Okada, Asami Okada, Hiromichi Narumiya, Ryoji Iiduka, Kanade Katsura
A previously healthy 55-year-old man with H1N1 influenza A presented with severe respiratory failure and cardiac arrest. Following the return of spontaneous circulation, venovenous extracorporeal membrane oxygenation was required to maintain oxygenation. On day 2, bronchoscopy revealed a bloody bronchial cast obstructing the right main bronchus. A pathological examination revealed that it was composed of intrabronchial and intra-alveolar hemorrhagic tissue. Unfortunately, the patient died due to severe brain ischemia; a subsequent autopsy revealed marked alveolar hemorrhage...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28915141/clinical-success-stenting-distal-bronchi-for-lobar-salvage-in-bronchial-stenosis
#3
Sonali Sethi, Thomas R Gildea, Francisco A Almeida, Joseph C Cicenia, Michael S Machuzak
BACKGROUND: Airway stents are traditionally used in central airway obstructions to maintain airway patency. Historically, distal bronchial stenting within lobar and segmental bronchi has not been amenable to stenting. In addition, there are questionable benefits to stenting small airways. The Atrium iCast stent is a polytetrafluoroethylene covered stainless steel balloon deployed stent which can be deployed through a flexible bronchoscope under direct visualization. The purpose of this study was to assess the feasibility, complications, and long-term impact of using this stent in patients with lobar bronchial stenosis either secondary to malignancy or benign etiologies...
September 14, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28906034/small-airway-disease-a-different-phenotype-of-early-stage-copd-associated-with-biomass-smoke-exposure
#4
Dongxing Zhao, Yumin Zhou, Changbin Jiang, Zhuxiang Zhao, Fang He, Pixin Ran
BACKGROUND AND OBJECTIVE: Chronic exposure to biomass smoke (BS) can significantly compromise pulmonary function and lead to chronic obstructive pulmonary disease (COPD). To determine whether BS exposure induces a unique phenotype of COPD from an early stage, with different physiopathological features compared with COPD associated with smoking (cigarette-smoke (CS) COPD), we assessed the physiopathology of early COPD associated with BS exposure (BS COPD) by incorporating spirometry, high-resolution computed tomography (HRCT) imaging, bronchoscopy and pathological examinations...
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28901394/overexpression-of-atp5b-promotes-cell-proliferation-in-asthma
#5
Jianhong Zuo, Mingsheng Lei, Meilin Wen, Yikun Chen, Zhigang Liu
Asthma is a complicated systemic disease of the airways, which is characterized by variable symptoms, including bronchial hyper‑responsive-ness, inflammation and airflow obstruction. The prevalence of asthma has increased 2‑3‑fold over recent decades in developed countries; however, the molecular mechanism of asthma remains unclear. In the current study, the expression of recombinant protein Dermatophagoides farinaeI (Derf I) was induced by isopropyl β‑D‑1‑thiogalactoside (IPTG) and purified using Ni‑NTA...
August 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28890532/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-a-case-report-and-review-of-the-literature
#6
Evangelos Koliakos, Theodoros Thomopoulos, Ziad Abbassi, Christophe Duc, Michel Christodoulou
BACKGROUND Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare pulmonary disorder that is characterized by diffuse hyperplasia of bronchiolar and bronchial pulmonary neuroendocrine cells. In this condition, when no other pathological pulmonary condition is detected, DIPNECH is considered to be an idiopathic lung disease. DIPNECH is a rare condition that can be difficult to distinguish from other forms of reactive pulmonary neuroendocrine cell hyperplasia (NECH). We present a case of DIPNECH and describe the approach to diagnosis of this rare condition...
September 11, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28885335/rescue-patient-from-tracheal-obstruction-by-dislocated-bronchial-stent-during-tracheostomy-surgery-with-readily-available-tools-a-case-report
#7
Hung-Yu Chang, Kee-Ming Man, Kate Hsiurong Liao, Yi-Ying Chiang, Kuen-Bao Chen
RATIONALE: Airway stenting is a well-established method that relieves symptoms and maintains airway patency in patients with airway obstruction. Serious complications caused by airway stents such as stent dislocation and airway obstruction during surgery are life-threatening. PATIENT CONCERNS: An 80-year-old man was treated with bronchial stent for left bronchus obstruction caused by metastatic esophageal cancer. During tracheostomy surgery, he suffered from acute tracheal obstruction caused by dislocated bronchial stent...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28884969/evaluation-of-bioequivalence-between-the-new-procaterol-hydrochloride-hydrate-dry-powder-inhaler-and-the-approved-dry-powder-inhaler-in-patients-with-asthma-in-a-randomized-double-blind-double-dummy-crossover-comparison-study-a-phase%C3%A2-3-study
#8
Ryo Shirai, Yuki Suzaki, Kyoko Sato, Yuko Takeuchi, Issei Tokimatsu, Nobuyuki Koga, Junichi Kadota, Kyoichi Ohashi
Procaterol hydrochloride hydrate (procaterol) is a β2 -adrenergic receptor agonist that induces a strong bronchodilatory effect. The procaterol dry powder inhaler (DPI) has been frequently used in patients with bronchial asthma or chronic obstructive pulmonary disease. We evaluated the bioequivalence and safety between the new procaterol DPI (new DPI) and the approved procaterol DPI (approved DPI). This study was a randomized, double-blind, double-dummy, crossover comparison to evaluate the pharmacodynamic equivalence of the new DPI and the approved DPI in patients with bronchial asthma...
September 8, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28882976/endobronchial-carcinoid-tumor-totally-occluding-the-left-main-bronchus-without-producing-symptoms-of-bronchial-obstruction
#9
Diamantis I Tsilimigras, Demetrios Moris, Ioannis Ntanasis-Stathopoulos, Davide Patrini, Nikolaos Panagiotopoulos
BACKGROUND: Bronchial carcinoid tumors (BCTs) are rare neuroendocrine neoplasms of the lung that mainly have a central distribution. They are classified as typical and atypical, with the former variant generally conferring a more favorable survival. Central tumors are usually symptomatic with features of bronchial obstruction, whereas peripheral tumors may remain silent. CASE REPORT: A 36-year-old woman presented to our hospital due to an episode of massive hemoptysis 5 days prior to admission...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28881345/difference-in-mortality-risk-in-elderly-people-with-bronchial-obstruction-diagnosed-using-a-fixed-cutoff-or-the-lower-limit-of-normal-of-the-fev1-fvc-ratio
#10
Claudio Pedone, Renato Giua, Nicola Scichilone, Francesco Forastiere, Vincenzo Bellia, Raffaele Antonelli Incalzi
BACKGROUND: Whether a fixed cutoff or the lower limit of normal of the FEV1/FVC ratio should be used to diagnose bronchial obstruction is still a matter of debate. This issue is particularly important for elderly people. OBJECTIVES: We used equations applicable up to 90 years of age to evaluate the mortality of elderly people diagnosed with bronchial obstruction using either a fixed cutoff of 0.7 or the lower limit of normal (LLN). METHODS: Participants in the SaRA (Salute Respiratoria nell'Anziano, Italian for "Respiratory Health in the Elderly") study were grouped as follows: FEV1/FVC ≥0...
September 8, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28867718/role-of-mast-cells-in-bronchial-contraction-in-nonallergic-obstructive-lung-pathology
#11
Nataliya A Kuzubova, Elena S Lebedeva, Olga N Titova, Anatoliy N Fedin, Ivetta V Dvorakovskaya
The role of mast cells in contractile bronchial smooth muscle activity has been evaluated in a model of chronic obstructive pulmonary disease induced in rats that were intermittently exposed to nitrogen dioxide (NO2) for 60 days. Starting from the 31st day, one group of rats inhaled sodium cromoglycate before exposure to NO2 to stabilize mast cell membranes. The second group (control) was not treated. Isometric smooth muscle contraction was analysed in isolated bronchial samples in response to nerve and smooth muscle stimulation...
2017: Journal of Smooth Muscle Research, Nihon Heikatsukin Gakkai Kikanshi
https://www.readbyqxmd.com/read/28864214/microrna-218-acts-by-repressing-tnfr1-mediated-activation-of-nf-%C3%AE%C2%BAb-which-is-involved-in-muc5ac-hyper-production-and-inflammation-in-smoking-induced-bronchiolitis-of-copd
#12
Hui Xu, Qian Sun, Lu Lu, Fei Luo, Liang Zhou, Jianping Liu, Lei Cao, Qiushi Wang, Junchao Xue, Qianlei Yang, Ping Yang, Jiachun Lu, Quanyong Xiang, Qizhan Liu
Dysregulation of microRNAs (miRNAs) has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), which is largely attributable to cigarette smoke (CS). However, little is known about the effect of miRNAs on CS-induced mucus hypersecretion and the inflammatory response in the airway epithelium, which are pathological characteristics of COPD-related chronic bronchiolitis. As determined in the present investigation, population-based data indicate that smokers with COPD had serious airflow obstruction and inflammation, whereas smokers without COPD had mild airflow obstruction and inflammation...
August 31, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28862493/an-official-american-thoracic-society-workshop-report-presentations-and-discussion-of-the-sixth-jack-pepys-workshop-on-asthma-in-the-workplace
#13
Susan M Tarlo, Jean-Luc Malo, Frédéric de Blay, Nicole Le Moual, Paul Henneberger, Dick Heederik, Monika Raulf, Christopher Carlsten, André Cartier
The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work-related asthma and airway diseases: (1) cleaning agents and disinfectants (including in swimming pools) as irritants and sensitizers: how to evaluate types of bronchial reactions and reduce risks; (2) population-based studies of occupational obstructive diseases: use of databanks, advantages and pitfalls, what strategies to deal with biases and confounding?; (3) damp environments, dilapidated buildings, recycling processes, and molds, an increasing problem: mechanisms, how to assess causality and diagnosis; (4) diagnosis of occupational asthma and rhinitis: how useful are recombinant allergens (component-resolved diagnosis), metabolomics, and other new tests?; (5) how does exposure to gas, dust, and fumes enhance sensitization and asthma?; and (6) how to determine probability of occupational causality in chronic obstructive pulmonary disease: epidemiological and clinical, confirmation, and compensation aspects...
September 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28862414/asthma-copd-overlap-syndrome-recent-advances-in-diagnostic-criteria-and-prognostic-significance
#14
Claudio Sorino, Nicola Scichilone, Maria D'Amato, Vincenzo Patella, Fabiano DI Marco
The term asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) has been proposed for individuals with features of both asthma and COPD. Several attempts have been done to define ACOS on the basis of medical history, symptoms, and functional findings. The main diagnostic criteria include airflow obstruction with a strong although incomplete reversibility to bronchodilation tests, a significant exposure to cigarette or biomass smoke, and a history of atopy or asthma. Additional diagnostic elements include eosinophilic airway and systemic inflammation, a good response to corticosteroid treatment, and a high concentration of exhaled nitric oxide...
June 2017: Minerva Medica
https://www.readbyqxmd.com/read/28860664/cadmium-induced-er-stress-and-inflammation-are-mediated-through-c-ebp-ddit3-signaling-in-human-bronchial-epithelial-cells
#15
Jeeyoung Kim, Haengseok Song, Hye-Ryeon Heo, Jung Woon Kim, Hye-Ryun Kim, Yoonki Hong, Se-Ran Yang, Seon-Sook Han, Seung-Joon Lee, Woo Jin Kim, Seok-Ho Hong
Cadmium (Cd), a major component of cigarette smoke, disrupts the normal functions of airway cells and can lead to the development of various pulmonary diseases such as chronic obstructive pulmonary disease (COPD). However, the molecular mechanisms involved in Cd-induced pulmonary diseases are poorly understood. Here, we identified a cluster of genes that are altered in response to Cd exposure in human bronchial epithelial cells (BEAS-2B) and demonstrated that Cd-induced ER stress and inflammation are mediated via CCAAT-enhancer-binding proteins (C/EBP)-DNA-damaged-inducible transcript 3 (DDIT3) signaling in BEAS-2B cells...
September 1, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28851976/linoleic-acid-metabolite-leads-to-steroid-resistant-asthma-features-partially-through-nf-%C3%AE%C2%BAb
#16
Lipsa Panda, Atish Gheware, Rakhshinda Rehman, Manish K Yadav, B S Jayaraj, SubbaRao V Madhunapantula, Padukudru Anand Mahesh, Balaram Ghosh, Anurag Agrawal, Ulaganathan Mabalirajan
Studies have highlighted the role of nutritional and metabolic modulators in asthma pathobiology. Steroid resistance is an important clinical problem in asthma but lacks good experimental models. Linoleic acid, a polyunsaturated fatty acid, has been linked to asthma and glucocorticoid sensitivity. Its 12/15-lipoxygenase metabolite, 13-S-hydroxyoctadecadienoic acid (HODE) induces mitochondrial dysfunction, with severe airway obstruction and neutrophilic airway inflammation. Here we show that HODE administration leads to steroid unresponsiveness in an otherwise steroid responsive model of allergic airway inflammation (AAI)...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840018/the-role-of-bone-marrow-derived-endothelial-progenitor-cells-and-angiogenic-responses-in-chronic-obstructive-pulmonary-disease
#17
REVIEW
Brittany Salter, Roma Sehmi
Increased vascularity of the bronchial sub-mucosa is a cardinal feature of chronic obstructive pulmonary disease (COPD) and is associated with disease severity. Capillary engorgement, leakage, and vasodilatation can directly increase airway wall thickness resulting in airway luminal narrowing and facilitate inflammatory cell trafficking, thereby contributing to irreversible airflow obstruction, a characteristic of COPD. Airway wall neovascularisation, seen as increases in both the size and number of bronchial blood vessels is a prominent feature of COPD that correlates with reticular basement membrane thickening and airway obstruction...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28838976/clinical-and-biological-characteristics-of-the-french-cobra-cohort-of-adult-subjects-with-asthma
#18
Marina Pretolani, David Soussan, Isabelle Poirier, Gabriel Thabut, Michel Aubier
The COhort of BRonchial obstruction and Asthma (COBRA) is a longitudinal cohort that involves 12 French academic institutions. DNA, serum samples and clinical data are collected at entry and every 6 months thereafter.Of 1080 patients with asthma recruited between 2007 and 2015, 401 had mild/moderate and 613 had severe asthma. In cross-sectional analyses, compared with patients with milder disease, patients with severe asthma had more symptoms, exacerbations, hospitalisations and visits to the emergency department during the preceding 12 months, higher numbers of blood eosinophils, and more comorbidities...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28829345/allergies-and-exercise-induced-bronchoconstriction-in-a-youth-academy-and-reserve-professional-soccer-team
#19
Valérie Bougault, François Drouard, Franck Legall, Grégory Dupont, Benoit Wallaert
OBJECTIVES: A high prevalence of respiratory allergies and exercise-induced bronchoconstriction (EIB) has been reported among endurance athletes. This study was designed to analyze the frequency of sensitization to respiratory allergens and EIB in young soccer players. DESIGN: Prospective cohort design. SETTING: Youth academy and reserve professional soccer team during the seasons 2012 to 2013 and 2013 to 2014. PARTICIPANTS: Eighty-five soccer players (mean age: 20 ± 4 years) participated...
September 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28806967/microrna-181c-inhibits-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease-by-regulating-ccn1-expression
#20
Yong Du, Yi Ding, Xuru Chen, Zhoufang Mei, Heyuan Ding, Yi Wu, Zhijun Jie
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an obstinate pulmonary disease, causing irreversible alveoli collapse and increasing the risk for cardiovascular disease. Accumulating evidence has shown that the dysregulation of miRNAs is crucially involved in the pathogenesis and development of COPD. However, the effects and role of microRNA-181c (miR-181c) have not been investigated in a murine model of COPD. METHODS: miR-181c expression was detected in human lung tissue samples of 34 patients, an in vivo murine model of CS exposure, and primary human bronchial epithelial cells (HBECs) by qRT-PCR...
August 15, 2017: Respiratory Research
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