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Bronchial obstruction

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https://www.readbyqxmd.com/read/29783140/congenital-diaphragmatic-disease-an-unusual-presentation-in-adulthood-case-report
#1
Angela Gurrado, Roberta Maria Isernia, Alessandro De Luca, Valentina Ferraro, Daniela Virgintino, Anna Napoli, Giuseppe Cavallaro, Eugenio Maiorano, Angela Pezzolla, Mario Testini
INTRODUCTION: Congenital diaphragmatic disease is a quite common condition that usually occurs in the neonatal period, and the diagnosis of congenital diaphragmatic disease in adulthood is rare. CASE PRESENTATION: A 64-years-old Caucasian woman was admitted in emergency at our Department, due to a bowel obstruction and dyspnea. A CT-scan showed a diaphragmatic herniation in the left area, with malposition of dilated transverse and descending colon in the chest. An emergency laparatomy was performed, showing a toxic megacolon, in the absence of a true diaphragmatic hernia, and a left diaphragm and left liver hypoplasia...
May 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29782663/prospective-study-confirms-that-bronchiolitis-in-early-infancy-increases-the-risk-of-reduced-lung-function-at-10-13-years-of-age
#2
Riikka Riikonen, Eero Lauhkonen, Sari Törmänen, Katri Backman, Petri Koponen, Merja Helminen, Kirsi Nuolivirta, Matti Korppi
AIM: This study evaluated children hospitalised for bronchiolitis at less than six months of age to see if they had reduced lung function in early adolescence. METHODS: We have prospectively followed 166 children hospitalised for infant bronchiolitis in 2001-2004 at Tampere University Hospital, Finland. At 10-13 years of age, flow-volume spirometry was measured in 89 cases and 108 controls without infant bronchiolitis from the local population register. Parameters of flow-volume spirometry before and after bronchodilation were analysed...
May 21, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29773293/usefulness-of-the-forced-oscillation-technique-in-assessing-the-therapeutic-result-of-tracheobronchial-central-airway-obstruction
#3
Masanori Yasuo, Yoshiaki Kitaguchi, Fumiya Kinota, Makoto Kosaka, Kazuhisa Urushihata, Atsuhito Ushiki, Hiroshi Yamamoto, Satoshi Kawakami, Masayuki Hanaoka
BACKGROUND: Pulmonary function tests (PFTs) comprise the traditional method for detecting central airway obstruction (CAO) and evaluating therapeutic effects, but are effort-dependent. By contrast, the forced oscillation technique (FOT) is performed during tidal breathing in an effort-independent mode and is universally used to assess respiratory function in patients with chronic obstructive pulmonary disease (COPD) and asthma. We used the FOT to measure airway resistance and reactance in patients with CAO before and after interventional bronchoscopy and compared the results to data obtained using PFTs...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29771095/-a-progress-of-macrolides-therapy-for-chronic-rhinosinusitis
#4
REVIEW
S Shen, C S Wang
Macrolides are a type of antibiotics with macrocyclic lactone ring, which have been commonly used in the treatment of diffuse panbronchiolitis, chronic obstructive pulmonary disease, bronchial asthma, cystic fibrosis and other diseases. Macrolides not only have effect on antibacterial, but also effect on anti-inflammatory and immunoregulation. Chronic rhinosinusitis (CRS) is a common disease entity of infectious and inflammatory diseases that involved in nasal cavity and nasal sinuses, with various clinical phenotypes...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29767634/measurement-and-estimation-of-human-forced-expiratory-noise-parameters-using-a-microphone-with-a-stethoscope-head-and-a-lapel-microphone
#5
Anna Yur'evna Glazova, Vladimir I Korenbaum, Anatoly E Kostiv, Oksana I Kabancova, Alexander A Tagiltcev, Svetlana N Shin
The time signature of tracheal noise in the 200-2000 Hz frequency band recorded during a forced expiratory manoeuvre (FETa) is a promising tool for diagnosis of bronchial obstructions. FETa is typically registered using a microphone with a stethoscope head placed on the neck over the trachea (stethoscope sensor). We studied basic time and spectral parameters of forced expiratory tracheal noises with a microphone placed near the mouth (lapel microphone, outside the flow of exhaled air) and compared these with measurements via stethoscope sensor, with the aim of providing patient home monitoring via standard personal computer facilities...
May 16, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29766735/-a-case-of-post-intubation-tracheal-stenosis-mimicking-bronchial-asthma-case-report
#6
Monika Šatánková, Kristián Brat, Zdeněk Merta, Miloš Šteffl
Postintubation tracheal stenosis (PITS) is one of the most frequent causes of lower airways obstruction. Usually, PITS is the consequence of prolonged intubation period, but may occur also after short-term intubation. Diagnosis may be difficult if stridor is not present and the post-extubation period is many years long. Bronchoscopy and CT scanning are the diagnostic gold standard. In some cases, lung function tests may also be helpful. Treatment options include conservative treatment, surgery and endoscopic methods...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29760450/caveolin-3-differentially-orchestrates-cholinergic-and-serotonergic-constriction-of-murine-airways
#7
M Keshavarz, M Skill, M I Hollenhorst, S Maxeiner, M Walecki, U Pfeil, W Kummer, G Krasteva-Christ
The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, cholesterol-rich domains of the plasma membrane, termed caveolae due to their invaginated shape. The structural protein caveolin-1 partly accounts for anchoring of these receptors. We here determined the role of the other major caveolar protein, caveolin-3 (cav-3), in orchestrating cholinergic and serotonergic ASM responses, utilizing newly generated cav-3 deficient mice...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29754840/-respiratory-physiotherapy-in-acute-viral-bronchiolitis-in-the-newborn-pro-con-arguments
#8
REVIEW
G Postiaux, P Maffei, J-C Villiot-Danger, J-C Dubus
This article reports an exchange of unbiased arguments between Mr Guy Postiaux speaking in favour of respiratory physiotherapy in acute viral bronchiolitis in the newborn and Prof. Jean-Christoph Dubus arguing against. A review of the literature suggests that traditional methods of physiotherapy should be abandoned because they are not validated and because they have harmful side effects. The latest Cochrane revue (2016) suggests the use of slow expiration techniques that have some validated elements and cause no harmful side effects...
May 10, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29748308/fibroblast-growth-factor-23-and-klotho-contribute-to-airway-inflammation
#9
Stefanie Krick, Alexander Grabner, Nathalie Baumlin, Christopher Yanucil, Scott Helton, Astrid Grosche, Juliette Sailland, Patrick Geraghty, Liliana Viera, Derek W Russell, J Michael Wells, Xin Xu, Amit Gaggar, Jarrod Barnes, Gwendalyn D King, Michael Campos, Christian Faul, Matthias Salathe
Circulating levels of fibroblast growth factor (FGF) 23 are associated with systemic inflammation and increased mortality in chronic kidney disease. α-klotho, a co-receptor for FGF23, is downregulated in chronic obstructive pulmonary disease (COPD). However, whether FGF23 and klotho-mediated FGFR activation delineates a pathophysiologic mechanism in COPD remains unclear. We hypothesized that FGF23 can potentiate airway inflammation via klotho independent FGFR4 activation. FGF23 and its effect were studied using plasma and transbronchial biopsies from COPD and control patients and primary human bronchial epithelial cells isolated from COPD patients as well as a murine COPD model...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748063/-is-reduction-of-tobacco-consumption-associated-with-reduced-risk-of-cardiovascular-and-pulmonary-mortality-and-morbidity
#10
REVIEW
M Underner, G Peiffer, J Perriot, G Harika-Germaneau, N Jaafari
INTRODUCTION: Smokers without an intention to completely quit smoking often try to reduce their daily tobacco consumption. However, smoking reduction is not associated with reduced risk of all-cause mortality. The aim of this systematic literature review of data was to expose relations between reduction of daily tobacco consumption and a potential decrease in the risks of cardiovascular and pulmonary mortality and morbidity. METHOD: Medline, on the period 1980-2018 with the following keywords: "smoking reduction", "harm reduction", "mortality", "morbidity", "cardiovascular disease* ", myocardial infarction", "coronar* ", "stroke", "lung cancer", "COPD", "chronic obstructive pulmonary disease", "asthma", "pulmonary disease* " and "respiratory disease" limits "title/abstract"; the selected languages were English or French...
May 7, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29745796/mechanical-properties-of-the-airway-tree-heterogeneous-and-anisotropic-pseudoelastic-and-viscoelastic-tissue-responses
#11
Mona Eskandari, Alberto Leyva Arvayo, Marc Elliot Levenston
Airway obstruction and pulmonary mechanics remain understudied despite lung disease being the third cause of death in the United States. Lack of relevant data has lead computational pulmonary models to infer mechanical properties from available material data for the trachea. Additionally, the time-dependent, viscoelastic behaviors of airways have been largely overlooked, despite the potential physiologic relevance and utility as metrics of tissue remodeling and disease progression. Here we address the clear need for airway-specific material characterization to inform biophysical studies of the bronchial tree...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29744319/correlation-of-severity-of-functional-gastrointestinal-disease-symptoms-with-that-of-asthma-and-chronic-obstructive-pulmonary-disease-a-multicenter-study
#12
Umesh Chandra Ojha, Devesh Pratap Singh, Omkar Kalidasrao Choudhari, Dipti Gothi, Shweta Singh
Introduction: There is a growing clinical awareness about the influence of gut-lung axis on lung injury and coexisting manifestations of disease processes in both the intestine and lungs. Patients of chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and asthma very often present with coexistent gut symptoms. In the present study, we have tried to establish the correlation of severity of pulmonary pathology of COPD and asthma patients with functional gastrointestinal (GI) symptoms of the patients...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29738272/fall-episodes-in-elderly-patients-with-asthma-and-copd-a-pilot-study
#13
Andrzej Bozek, Jerzy Jarzab, Ewa Hadas, Marek Jakalski, Giorgio Walter Canonica
OBJECTIVE: Evidence of an increased risk of falls in patients with chronic obstructive pulmonary disease (COPD) exists; however, this has not been studied in elderly asthmatic patients. The aim of the study was to determine the incidence of falls in elderly patients who were diagnosed with bronchial asthma compared to subjects with COPD. METHODS: A 12 - month prospective observational study in elderly outpatients with diagnosis of either asthma or COPD was conducted...
May 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29736245/pharmacological-properties-of-revefenacin-td-4208-a-novel-nebulized-long-acting-and-lung-selective-muscarinic-antagonist-at-human-recombinant-muscarinic-receptors-and-in-rat-guinea-pig-and-human-isolated-airway-tissues
#14
Sharath S Hegde, M Teresa Pulido-Rios, Mark A Luttmann, James J Foley, Gerald E Hunsberger, Tod Steinfeld, TaeWeon Lee, Yuhua Ji, Mathai M Mammen, Jeffrey R Jasper
Revefenacin (TD-4208) is a novel, long-acting, and lung-selective muscarinic cholinergic receptor (mAChR) antagonist in development as a nebulized inhalation solution for the treatment of chronic obstructive pulmonary disease (COPD) patients. This study evaluated the pharmacology of revefenacin at human recombinant mAChRs and in airway tissues from rats, guinea pigs, and humans. At human recombinant mAChRs, revefenacin displayed high affinity (pKI  = 8.2-9.8) and behaved as a competitive antagonist (pKI, apparent = 9...
June 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29731655/immune-regulating-effects-of-exercise-on-cigarette-smoke-induced-inflammation
#15
REVIEW
Ashkan Madani, Katharina Alack, Manuel Jonas Richter, Karsten Krüger
Long-term cigarette smoking (LTCS) represents an important risk factor for cardiac infarction and stroke and the central risk factor for the development of a bronchial carcinoma, smoking-associated interstitial lung fibrosis, and chronic obstructive pulmonary disease. The pathophysiologic development of these diseases is suggested to be promoted by chronic and progressive inflammation. Cigarette smoking induces repetitive inflammatory insults followed by a chronic and progressive activation of the immune system...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29730328/poor-subpleural-perfusion-predicts-failure-after-balloon-pulmonary-angioplasty-for-non-operable-chronic-thromboembolic-pulmonary-hypertension
#16
Yu Taniguchi, Philippe Brenot, Xavier Jais, Carlos Garcia, Jason Weatherald, Olivier Planche, Elie Fadel, Marc Humbert, Gérald Simonneau
BACKGROUND: Poor subpleural perfusion (PSP) in the capillary phase of pulmonary angiography predicts worse outcomes after pulmonary endarterectomy in operable chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) has emerged for non-operable CTEPH. We assessed the association between PSP and BPA failure. METHOD: Subpleural perfusion was classified as poor (defined as subpleural spaces either not or minimally perfused in all segments) or normal...
May 3, 2018: Chest
https://www.readbyqxmd.com/read/29729177/clinical-and-pathogenetic-features-of-nonalcoholic-steatohepatitis-for-comorbidity-with-bronchial-asthma-on-the-background-of-obesity
#17
Oksana S Khukhlina, Alona A Antoniv, Olha Ye Mandryk, Olha Yе Hryniuk, Svitlana V Kovalenko, Victoria Yu Drozd, Zoriana Ia Kotsiubiichuk
OBJECTIVE: Introduction: The comorbid flow of non-alcoholic steatohepatitis (NASH) and bronchial asthma (BA) on the background of obesity is often recently drawn to the attention of both practitioners and researchers . The aim of our study was to study the changes in the functional state of the liver and the dependence of the external respiration function in patients with non-alcoholic steatohepatitis in combination with bronchial asthma and obesity. PATIENTS AND METHODS: Materials and methods: The study was attended by 50 people aged from 30 to 50 years (average age 42 years), of which 40% were men and 60% women...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29729164/cluster-analysis-of-the-phenotype-of-asthma-and-obesity
#18
Victoria S Sukhan
OBJECTIVE: Introduction: The combination of asthma and obesity can affect the mutual encumbrance to which other pathogenetic mechanisms join, which worsen the course of both diseases. The aim of the work is to analyze the features of the genotype and phenotype in patients with a combined course of asthma and obesity. PATIENTS AND METHODS: Materials and methods: In order to detect the features of obesity asthma, 108 patients were examined. Patients were divided into two groups: the first included 50 patients with normal body weight, the second - 58 patients with obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29722565/mmp-12-activates-protease-activated-receptor-par-1-upregulates-placenta-growth-factor-and-leads-to-pulmonary-emphysema
#19
Hsin-Han Hou, Hao-Chien Wang, Shih-Lung Cheng, Yen-Fu Chen, Kai-Zen Lu, Chong-Jen Yu
Due to the expansion of aging and smoking populations, chronic pulmonary obstructive disease (COPD) is predicted to be the third leading cause of death worldwide in 2030. It is therefore pertinent to develop effective therapy to improve management for COPD. Cigarette smoke-mediated protease-antiprotease imbalance is a major pathogenic mechanism for COPD and results in massive pulmonary infiltration of neutrophils and macrophages, releasing excessive neutrophil elastase (NE) and matrix metalloproteinases (MMPs)...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29717122/therapeutic-potential-of-a-phospholipase-d1-inhibitory-peptide-fused-with-a-cell-penetrating-peptide-as-a-novel-anti-asthmatic-drug-in-a-der-f-2-induced-airway-inflammation-model
#20
Yun Young Lee, So Young Lee, Shin-Young Park, Hye-Jin Choi, Eung-Gook Kim, Joong-Soo Han
Asthma is a chronic lung disease that causes airflow obstruction due to airway inflammation. However, its therapeutics remain inadequate. We previously reported that phospholipase D1 (PLD1) is a key enzyme involved in the production of pro-inflammatory cytokines in airway inflammation induced by the house dust mite allergen Dermatophagoides farinae 2 (Der f 2). We also revealed that PLD1 is specifically inactivated by AP180 (assembly protein, 180 kDa) and identified the PLD1-specific binding motif (TVTSP) of AP180...
May 1, 2018: Experimental & Molecular Medicine
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