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https://www.readbyqxmd.com/read/27779086/genetic-predictors-of-drug-hypersensitivity
#1
José A Cornejo-García, Abderrahim Oussalah, Miguel Blanca, Rosa-María Guéant-Rodríguez, Cristobalina Mayorga, Julie Waton, Annick Barbaud, Francesco Gaeta, Antonino Romano, Jean-Louis Guéant
Our knowledge of genetic predisposing factors of drug hypersensitivity reactions (DHRs) is still scarce. The analysis of the genetic basis of these reactions may contribute to dissect the underlying mechanisms. We will outline current knowledge of the genetic predictors of most common DHRs, including reactions to betalactam antibiotics (BLs), nonsteroidal anti-inflammatory drugs (NSAIDs) and biological agents. The predictors of DHRs to BLs are mostly linked to IgE-class switching, IgE pathway and atopy (IL4R, NOD2, LGALS3) in replicated candidate gene studies, and to antigen presentation (HLA-DRA) in the single replicated GWAS performed so far...
September 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27754445/l-asparaginase-isolated-from-phaseolus-vulgaris-seeds-exhibited-potent-anti-acute-lymphoblastic-leukemia-effects-in-vitro-and-low-immunogenic-properties-in-vivo
#2
Saleh A Mohamed, Mohamed F Elshal, Taha A Kumosani, Alia M Aldahlawi, Tasneem A Basbrain, Fauziah A Alshehri, Hani Choudhry
Escherichia coli-derived L-asparaginases have been used in the treatment of acute lymphoblastic leukemia (ALL), however, clinical hypersensitivity reactions and silent inactivation due to antibodies against E. coli-asparaginase, lead to inactivation of these preparations in most cases.Therefore, this study was aimed to investigate the cytotoxicity and antitumor effects ofa novel L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds (P-Asp) on the ALL cell line (Jurkat). The immunogenicity of the enzyme was also evaluated in-vivo and results were compared to commercially available enzymes of microbial sources...
October 14, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/25017678/adverse-events-to-nontargeted-and-targeted-chemotherapeutic-agents-emphasis-on-hypersensitivity-responses
#3
REVIEW
Brian A Baldo, Mauro Pagani
Use of cytotoxic agents is associated with potential hypersensitivity reactions which are common with platinum compounds, L-asparaginase, taxanes, procarbazine and epipodophyllotoxins. Mechanisms underlying the reactions may involve IgE, non-allergic or a number of pathogenetically unclear events. Targeted therapies produce less collateral damage but demonstrate their own unique reactions. Cytopenias occur less often and mucocutaneous reactions to EGFR inhibitors, including papulopustular rash, are common. Fifteen currently approved mAbs provoke all four types of hypersensitivities including immune cytopenias, vasculitis, serum sickness and pulmonary events...
August 2014: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/23581640/expression-of-cd203c-on-basophils-as-a-marker-of-immunoglobulin-e-mediated-l-asparaginase-allergy
#4
Moeko Hino, Naoki Shimojo, Hidemasa Ochiai, Yuzaburo Inoue, Kumiko Ando, Koji Chikaraishi, Setsuo Ota, Yuri Okimoto, Shosuke Sunami, Ryosuke Nakamura, Reiko Teshima, Yasunori Sato, Yoichi Kohno
Immediate allergy to l-asparaginase (ASP) is a major obstacle in treating lymphoid malignancies. ASP-specific immunoglobulin G (ASP-IgG) has been used as a surrogate marker. Recently, the CD203c-basophil activation test (BAT) was found to be useful in diagnosing IgE-mediated allergies. We compared the diagnostic utility of the CD203c-BAT to that of ASP-IgG levels in determining ASP allergies in children. Eight ASP allergic reactions occurred over 75 ASP treatment courses. The sensitivity, specificity and area under the receiver operating characteristic curve of CD203c-BAT were similar to the ASP-IgG levels (0...
January 2014: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/22987983/prevention-and-handling-of-acute-allergic-and-infusion-reactions-in-oncology
#5
M Joerger
Drug hypersensitivity reactions (HSR) are adverse events resembling allergy which occur at therapeutic doses. Both anticancer chemotherapeutics and monoclonal antibodies have the potential for acute HSR. all infusion reactions involve the immune system; however, some (anaphylactic) are allergic in nature and usually are mediated by immunoglobulin E (IgE), whereas others (anaphylactoid) are not true allergic reactions and are not mediated by IgE. although HSR can be allergic or nonallergic, the clinical manifestations are the same and require prompt, accurate assessment and management to avoid severe adverse events, including fatality...
September 2012: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/20609866/the-complex-clinical-picture-of-presumably-allergic-side-effects-to-cytostatic-drugs-symptoms-pathomechanism-reexposure-and-desensitization
#6
REVIEW
Mauro Pagani
The number of drugs used for the treatment of different types of cancers is constantly increasing and actually exceeds 100 distinct chemical formulations. The use of most cytotoxic agents is associated with potential hypersensitivity reactions, and the constant increase of their administration has caused an increase in incidence of these adverse effects, thus becoming a relevant problem for clinicians. Hypersensitivity reactions are common with platinum compounds, L-asparaginase, taxanes, procarbazine, and epipodophyllotoxins, whereas they are unusual, but always possible, with the other chemotherapeutic drugs...
July 2010: Medical Clinics of North America
https://www.readbyqxmd.com/read/19354063/diagnosis-and-management-of-hypersensitivity-reactions-related-to-common-cancer-chemotherapy-agents
#7
REVIEW
Christina Lee, Mary Gianos, William B Klaustermeyer
OBJECTIVES: To review clinical hypersensitivity reactions related to common cancer chemotherapy agents and to discuss potential management strategies. DATA SOURCES: PubMed searches were performed for articles published from 1970 to 2008 regarding hypersensitivity to cancer chemotherapy and related agents using the keywords hypersensitivity, allergy, chemotherapy, platinums, taxanes, asparaginase, epipodophyllotoxins, and procarbazine. Retrieved articles were surveyed for additional citations...
March 2009: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/16037832/recurrent-acalculous-cholecystitis-and-sclerosing-cholangitis-in-a-patient-with-x-linked-hyper-immunoglobulin-m-syndrome
#8
Sheng-Chieh Lin, Shyh-Dar Shyur, Yi-Chun Ma, Li-Hsin Huang, Hung-Chang Lee, Wen-I Lee
X-linked hyper-immunoglobulin M (IgM) syndrome (XHIGM) is a rare genetic primary immunodeficiency disease caused by mutations of the CD40 ligand (CD40L) gene with normal or elevated levels of IgM and markedly decreased serum IgG, IgA, and IgE. Liver disease may occur as a clinical manifestation in XHIGM. This complication appears to increase with age. We report an 18-year-old male patient who had recurrent episodes of acalculous cholecystitis (AC) and sclerosing cholangitis (SC). The diagnosis of XHIGM was confirmed by the finding of CD40L expression < 1% of normal and a tyrosine 169 asparaginase (t526a) mutation in exon 5 (the tumor necrosis factor domain) of the CD40L gene...
June 2005: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/15631188/-immunologic-monitoring-in-children-with-acute-lymphoblastic-leukemia-during-maintenance-treatment-with-regard-to-co-existing-infections
#9
COMPARATIVE STUDY
Włodzimierz Luczyński, Anna Stasiak-Barmuta, Maryna Krawczuk-Rybak, Janusz Zak
UNLABELLED: We analyzed the dynamics of changes in the immune system during maintenance treatment of acute lymphoblastic leukemia (ALL). The study was carried out on the group of 40 children aged 2-15 years (mean +/- 3.46), including 31 lower risk patients (Berlin-Frankfurt-Munich protocol--BFM) and 9 high risk patients (New York protocol--NY). Levels of IgA, IgG, IgM and IgE, and subsets of mononuclear cells using flow cytometry were evaluated in the study group every 1-3 months. During maintenance therapy we found markedly reduced leukocytosis, lymphocytosis, and mean values of IgA, IgM and IgG in comparison to healthy children...
2004: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/9010688/tolerance-evaluation-of-l-asparaginase-loaded-in-red-blood-cells
#10
R Kravtzoff, P H Colombat, I Desbois, C Linassier, J P Muh, T Philip, J Y Blay, M Gardenbas, P Poumier-Gaschard, J P Lamagnere, M Chassaigne, C Ropars
OBJECTIVE: A pilot clinical study was conducted to evaluate the toxicity of a single dose of L-asparaginase loaded in red blood cells (RBCs). METHODS: Thirteen patients received a single dose of L-asparaginase in the range 30-200 i.u.kg-1. The enzyme was loaded in one autologous blood unit using a lysis-resealing process. A control population of 33 patients receiving L-asparaginase intravenously were tested in parallel. IgG, IgM and IgE class anti-L-asparaginase antibodies were detected using specific radioimmunoassays...
1996: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/7105004/immunological-and-pharmacological-characterization-of-poly-dl-alanyl-modified-erwinia-carotovora-l-asparaginase
#11
J R Uren, B J Hargis, P Beardsley
The covalent attachment of poly-DL-alanine peptides to lysyl residues on the surface of Erwinia carotovora L-asparaginase has produced a modified enzyme which is much less immunogenic in mice and demonstrates 100-fold longer plasma half-life in the rhesus monkey. Immunogenic responses towards both the immunoglobulin G (IgG) and immunoglobulin E (IgE) antibody subclasses were evaluated in C57BL x DBA/2 F1 mice exposed to 250 rads of whole-body irradiation 4 hr prior to immunization with 5-diazo-4-oxynorvaline-inactivated native and modified L-asparaginase in complete Freund's adjuvant...
October 1982: Cancer Research
https://www.readbyqxmd.com/read/7028889/-chemical-modification-protein-antigen-and-its-immunoresponses-author-s-transl
#12
REVIEW
A Matsushima, Y Inada, T Yagura
No abstract text is available yet for this article.
1980: Seikagaku. the Journal of Japanese Biochemical Society
https://www.readbyqxmd.com/read/6548355/-preparation-of-repeatedly-and-effectively-usable-l-asparaginase-by-a-chemical-modification
#13
H Nishimura, H Wada, Y Inada
The anti-tumor activity of L-asparaginase (EC. 3.5.1.1.) has been conclusively demonstrated. Its therapeutic application, however, has been hampered by its short clearance time in the circulation and high immunogenicity. In order to solve these problems, polyethylene glycol, a linear synthetic and non-immunogenic polymer, was introduced covalently into the amino groups in the enzyme molecule. Monomethoxypolyethylene glycol with molecular weight of 5000 was activated with cyanuric chloride to obtain activated PEGs [2, 4-bis (O-methoxypolyethyleneglycol)-6-chloro-s-triazine]...
October 1984: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/5526343/studies-on-antibody-formation-in-patients-treated-with-l-asparaginase
#14
A Dohlwitz, S Franzén, A Holmgren, A Killander, D Killander, L Wide, L Ahström
No abstract text is available yet for this article.
1970: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/4993767/atopic-hypersensitivity-to-l-asparaginase-resistance-to-immunosuppression
#15
A Khan, J M Hill
No abstract text is available yet for this article.
1971: International Archives of Allergy and Applied Immunology
https://www.readbyqxmd.com/read/4738277/-studies-on-antibody-formation-by-l-asparaginase
#16
T Ito, T Ise, T Sawabe, N Nakayama, H Okura
No abstract text is available yet for this article.
May 1973: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/4101590/immunological-responses-to-l-asparaginase
#17
R G Peterson, R E Handschumacher, M S Mitchell
In a series of 40 patients treated with L-asparaginase for various neoplastic diseases, 6 patients had generalized anaphylactic reactions to L-asparaginase. Each of these reactors had antibodies detectable by passive hemagglutination, but precipitins were detectable in only one of this group of six patients. That patient had received two courses of the enzyme. 1 wk after the anaphylactic reaction, complement-fixing antibodies were present in all the patients that were studied. Specific reagin antibodies (IgE) were demonstrated in one patient by the release of histamine from his leukocytes after incubation in vitro with L-asparaginase...
May 1971: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/3980111/immune-responses-to-polyethylene-glycol-modified-l-asparaginase-in-mice
#18
K Kawamura, T Igarashi, T Fujii, Y Kamisaki, H Wada, S Kishimoto
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glycol (PEG, MW, 5,000) conjugated Escherichia coli A-ase. Following the administration of the mixture of A-ase and PEG-A-ase, antibody production to A-ase was reduced. PEG-A-ase administration prior to A-ase suppressed the primary and secondary responses to A-ase antibody. The suppression could be transferred to normal mice with spleen cells from A-ase tolerant mice. The cell transfer experiment showed that the suppression was caused by suppressor T cells...
1985: International Archives of Allergy and Applied Immunology
https://www.readbyqxmd.com/read/3858789/anaphylaxis-to-l-asparaginase-during-treatment-for-acute-lymphoblastic-leukemia-in-children-evidence-of-a-complement-mediated-mechanism
#19
U Fabry, D Körholz, H Jürgens, U Göbel, V Wahn
L-Asparaginase (l-Asp) is widely used as an effective drug against childhood and adult acute lymphoblastic leukemia (ALL). However, it is immunogenic in humans and may lead to hypersensitivity reactions. The immunological basis of these reactions is not clear. Since the presence of l-Asp specific IgG-antibodies seems to correlate better with clinical reactions than IgE-antibodies and IgG-antibodies are known to be able to fix and activate the complement system, we speculated that the mechanism of anaphylaxis may be complement- rather than IgE-mediated...
April 1985: Pediatric Research
https://www.readbyqxmd.com/read/3526939/antibody-response-to-escherichia-coli-l-asparaginase-prognostic-significance-and-clinical-utility-of-antibody-measurement
#20
N K Cheung, I Y Chau, P F Coccia
By using a modification of the microtiter solid-phase radioimmunoassay, we have measured Escherichia coli L-asparaginase (L-ASP) specific IgG, IgG4, and IgE antibodies in children who received L-ASP as part of their chemotherapy for leukemia and lymphoma. In 13 children with acute lymphoblastic leukemia induced with vincristine, prednisone, and L-ASP (10,000 IU/M2 i.v. each week for 3 weeks), seven developed high titer specific IgG antibodies. Four of the seven relapsed at the time of their peaking IgG response (6-10 months)...
1986: American Journal of Pediatric Hematology/oncology
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