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Eliza Tsitoura, Athol U Wells, Kostantinos Karagiannis, Ismini Lasithiotaki, Eirini Vasarmidi, Eleni Bibaki, Chara Koutoulaki, Hiroe Sato, Demetrios A Spandidos, Nikolaos M Siafakas, George Sourvinos, Katerina M Antoniou
MicroRNA signatures of BAL cells and alveolar macrophages are currently lacking in IPF. Here we sought to investigate the expression of fibrosis-related microRNAs in the cellular component of the BAL in IPF. We thus focused on microRNAs previously associated with fibrosis (miR-29a, miR-29b, miR-29c, let-7d, and miR-21) and rapid IPF progression (miR-185, miR-210, miR-302c-3p miR-376c and miR-423-5p). Among the tested microRNAs miR-29a and miR-185 were found significantly downregulated in IPF while miR-302c-3p and miR-376c were not expressed by BAL cells...
October 18, 2016: Oncotarget
E Rizos, N Siafakas, E Skourti, C Papageorgiou, J Tsoporis, T H Parker, D I Christodoulou, D A Spandidos, E Katsantoni, V Zoumpourlis
Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is conversely characterized by an increase in appropriate molecular signaling that stimulates uncontrolled cell proliferation. The rather low risk of developing Ca in patients suffering from SZ is a hypothesis that is still under debate...
October 14, 2016: Molecular Medicine Reports
Luca Falzone, Andrea Marconi, Carla Loreto, Sabrina Franco, Demetrios A Spandidos, Massimo Libra
It is well known that the occupational exposure to contaminants and carcinogens leads to the development of cancer in exposed workers. In the 18th century, Percivall Pott was the first to hypothesize that chronic exposure to dust in the London chimney sweeps was associated with an increased risk of developing cancer. Subsequently a growing body of evidence indicated that other physical factors were also responsible for oncogenic mutations. Over the past decades, many carcinogens have been found in the occupational environment and their presence is often associated with an increased incidence of cancer...
October 3, 2016: Molecular Medicine Reports
Daniel Boda, Monica Neagu, Carolina Constantin, Razvan Nicolae Voinescu, Constantin Caruntu, Sabina Zurac, Demetrios A Spandidos, Nikolaos Drakoulis, Dimitrios Tsoukalas, Aristides M Tsatsakis
The incidence of human papillomavirus (HPV) in the human cancer domain is still a subject of intensive study. In this study, we examined cervical swab samples from 713 females with genital warts, and tested the samples for high- and low-risk genital HPV. HPV genotyping was assessed using a Genotyping test that detects HPV by the amplification of target DNA using polymerase chain reaction and nucleic acid hybridization. In total, we detected 37 anogenital HPV DNA genotypes [6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39 and CP6108] and investigated the incidence of these genotypes in the patients with genital warts...
September 2016: Oncology Letters
Silvia Gangemi, Eliza Gofita, Chiara Costa, Michele Teodoro, Giusi Briguglio, Dragana Nikitovic, George Tzanakakis, Aristides M Tsatsakis, Martin F Wilks, Demetrios A Spandidos, Concettina Fenga
Pesticides can exert numerous effects on human health as a consequence of both environmental and occupational exposures. The available knowledge base suggests that exposure to pesticides may result in detrimental reproductive changes, neurological dysfunction and several chronic disorders, which are defined by slow evolution and long-term duration. Moreover, an ever increasing amount of data have identified an association between exposure to pesticides and the harmful effects on the immune system. The real impact of alterations in humoral cytokine levels on human health, in particular in the case of chronic diseases, is still unclear...
October 2016: International Journal of Molecular Medicine
Katerina Georgadaki, Nikolas Khoury, Demetrios A Spandidos, Vasilis Zoumpourlis
Fertilization is the fusion of the male and female gamete. The process involves the fusion of an oocyte with a sperm, creating a single diploid cell, the zygote, from which a new individual organism will develop. The elucidation of the molecular mechanisms of fertilization has fascinated researchers for many years. In this review, we focus on this intriguing process at the molecular level. Several molecules have been identified to play a key role in each step of this intriguing process (the sperm attraction from the oocyte, the sperm maturation, the sperm and oocyte fusion and the two gamete pronuclei fusion leading to the zygote)...
October 2016: International Journal of Molecular Medicine
Nina V Sayapina, Alexander A Sergievich, Vladimir L Kuznetsov, Vladimir V Chaika, Irina G Lisitskaya, Pavel P Khoroshikh, Tatyana A Batalova, Kostas Tsarouhas, Demetrios Spandidos, Aristidis M Tsatsakis, Concettina Fenga, Kirill S Golokhvast
Studies of the neurobehavioral effects of carbon nanomaterials, particularly those of multi-walled carbon nanotubes (MWCNTs), have concentrated on cognitive effects, but data are scarce. The aim of this study was to assess the influence of MWCNTs on a number of higher nervous system functions of Wistar rats. For a period of 10 days, two experimental groups were fed with MWCNTs of different diameters (MWCNT-1 group, 8-10 nm; MWCNT-2 group, 18-20 nm) once a day at a dosage of 500 mg/kg. In the open-field test, reductions of integral indications of researching activity were observed for the two MWCNT-treated groups, with a parallel significant (P<0...
September 2016: Experimental and Therapeutic Medicine
Kallirroi Voudouri, Dragana Nikitovic, Aikaterini Berdiaki, Dionysios J Papachristou, John Tsiaoussis, Demetrios A Spandidos, Aristides M Tsatsakis, George N Tzanakakis
Soft tissue sarcomas are rare, heterogeneous tumors of mesenchymal origin with an aggressive behavior. Heparin is a mixture of heavily sulfated, linear glycosaminoglycan (GAG) chains, which participate in the regulation of various cell biological functions. Heparin is considered to have significant anticancer capabilities, although the mechanisms involved have not been fully defined. In the present study, the effects of unfractionated heparin (UFH) and low‑molecular‑weight heparin (LMWH) on B6FS fibrosarcoma cell motility were examined...
August 30, 2016: Oncology Reports
Ismini Lasithiotaki, Eliza Tsitoura, Anastasios Koutsopoulos, Eleni Lagoudaki, Chara Koutoulaki, George Pitsidianakis, Demetrios A Spandidos, Nikolaos M Siafakas, George Sourvinos, Katerina M Antoniou
Merkel Cell Polyoma Virus (MCPyV) infection has been associated with non-small cell lung cancer (NSCLC). Viruses can manipulate cellular miRNAs or have a profound impact on cellular miRNA expression to control host regulatory pathways. In this study, we evaluated the expression profiles of cancer-associated and virally affected host microRNAs miR-21, miR-145, miR-146a, miR-155, miR-302c, miR-367 and miR-376c in a series of NSCLC tissue samples as well as in samples from "healthy" sites, distant from the tumour region that were either positive or negative for MCPyV DNA...
August 11, 2016: Oncotarget
Dragana Nikitovic, Rafaela-Maria Kavasi, Aikaterini Berdiaki, Dionysios J Papachristou, John Tsiaoussis, Demetrios A Spandidos, Aristides M Tsatsakis, George N Tzanakakis
Osteosarcoma (OS) is a primary bone tumor of mesenchymal origin mostly affecting children and adolescents. The OS extracellular matrix (ECM) is extensively altered as compared to physiological bone tissue. Indeed, the main characteristic of the most common osteoblastic subtype of OS is non‑mineralized osteoid production. Parathyroid hormone (PTH) is a polypeptide hormone secreted by the chief cells of the parathyroid glands. The PTH-related peptide (PTHrP) may be comprised of 139, 141 or 173 amino acids and exhibits considerate N‑terminal amino acid sequence homology with PTH...
October 2016: Oncology Reports
Vasilis P Androutsopoulos, Irene Fragiadaki, Demetrios A Spandidos, Androniki Tosca
Resveratrol is a natural dietary product that has demonstrated multifaceted anticancer activity. Several analogues of resveratrol have been synthesized in an effort to enhance the pharmacological potency and improve the pharmacokinetic properties of the compound. 3,4,5,4'‑trans‑tetramethoxystilbene (3,4,5,4'‑TMS) is a methoxylated analogue of resveratrol that has demonstrated anti-proliferative activity in vitro (in cancer cell lines) and in vivo (in xenograft models). In the present study, the anticancer effects of 3,4,5,4'‑TMS in A375 human melanoma cells were examined...
October 2016: International Journal of Oncology
Spanidis Ypatios, Stagos Dimitrios, Orfanou Marina, Goutzourelas Nikolaos, Bar-Or David, Spandidos Demetrios, Kouretas Demetrios
The aim of the present study was the monitoring of the redox status of runners participating in a mountain ultra-marathon race of 103 km. Blood samples from 12 runners were collected pre race and 24, 48 and 72 h post race. The samples were analyzed by using conventional oxidative stress markers, such as protein carbonyls (CARB), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) in plasma, as well as glutathione (GSH) levels and catalase (CAT) activity in erythrocytes. In addition, two novel markers the static oxidation-reduction potential marker (sORP) and the capacity oxidation-reduction potential (cORP) were measured in plasma...
July 25, 2016: Journal of Strength and Conditioning Research
Ioannis N Mammas, Demetrios A Spandidos
Hippocrates (Island of Kos, 460 B.C.-Larissa, 370 B.C.) is the founder of the most famous Medical School of the classical antiquity. In acknowledgement of his pioneering contribution to the new scientific field of Paediatric Virology, this article provides a systematic analysis of the Hippocratic Corpus, with particular focus on viral infections predominating in neonates and children. A mumps epidemic, affecting the island of Thasos in the 5th century B.C., is described in detail. 'Herpes', a medical term derived from the ancient Greek word 'ἕρπειν', meaning 'to creep' or 'crawl', is used to describe the spreading of cutaneous lesions in both childhood and adulthood...
August 2016: Experimental and Therapeutic Medicine
Ioannis N Mammas, Demetrios A Spandidos
No abstract text is available yet for this article.
August 2016: Experimental and Therapeutic Medicine
Cristina A Dehelean, Codruta Soica, Iulia Pinzaru, Dorina Coricovac, Corina Danciu, Ioana Pavel, Florin Borcan, Demetrios A Spandidos, Aristidis M Tsatsakis, Flavia Baderca
The increased susceptibility of men as compared to women to develop different types of cancer, including skin cancer, is well known; however, the mechanisms involved in this process are still a matter of debate. This study aimed to obtain animal models of photo-chemically-induced skin carcinogenesis by exposure to ultraviolet radiation B (UVB) coupled with topical applications of a tumor initiator (7,12-dimethylbenz(a)anthracene, DMBA) and a tumor promoter (12-O-tetradecanoylphorbol-13-acetate, TPA) in order to characterize the gender disparities regarding the skin lesions developed by the female and male SKH-1 hairless mice included in this study...
September 2016: Food and Chemical Toxicology
Martha-Spyridoula Katsarou, Rosana Latsi, Maria Papasavva, Nikolaos Demertzis, Thodoris Kalogridis, Aristides M Tsatsakis, Demetrios A Spandidos, Nikolaos Drakoulis
Hereditary hemochromatosis (HH) is an autosomal recessive genetic disease, characterized by increased dietary iron absorption. Due to the absence of an effective excretory mechanism, the excess iron in the body may accumulate resulting in toxic effects. The HFE gene also affects the activity of hepcidin, a hormone which acts as a negative regulator of iron metabolism. In this study, we performed a population-based analysis of the distribution of three hemochromatosis-related polymorphisms in the HFE gene (rs1800562, rs1799945 and rs1800730)...
July 2016: Molecular Medicine Reports
Persefoni Fragkiadaki, Dimitrios Tsoukalas, Irini Fragkiadoulaki, Christos Psycharakis, Dragana Nikitovic, Demetrios A Spandidos, Aristides M Tsatsakis
Telomeres are specific DNA regions positioned at the ends of chromosomes and composed of functional non-coding repeats. Upon cell division, the telomeres decrease in length by a preordained amount. When the telomeres become critically short, cells lose the ability to divide and enter a specific functioning mode designated as 'cellular senescence'. However, human tissues express an enzyme that deters the shrinking of the telomeres, the telomerase. Due to its ability to maintain telomere length, the telomerase slows down and possibly suspends the aging of the cells...
July 2016: Molecular Medicine Reports
Roberto Gambari, Eleonora Brognara, Demetrios A Spandidos, Enrica Fabbri
MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal transition and metastasis. Several studies conclusively have demonstrated that miRNAs are deeply involved in tumor onset and progression, either behaving as tumor-promoting miRNAs (oncomiRNAs and metastamiRNAs) or as tumor suppressor miRNAs. This review focuses on the most promising examples potentially leading to the development of anticancer, miRNA-based therapeutic protocols...
July 2016: International Journal of Oncology
Sabina Zurac, Monica Neagu, Carolina Constantin, Mirela Cioplea, Roxana Nedelcu, Alexandra Bastian, Cristiana Popp, Luciana Nichita, Razvan Andrei, Tiberiu Tebeica, Cristiana Tanase, Virginia Chitu, Constantin Caruntu, Mihaela Ghita, Catalin Popescu, Daniel Boda, Bogdan Mastalier, Nicoleta Maru, Claudiu Daha, Bogdan Andreescu, Ioan Marinescu, Adrian Rebosapca, Florica Staniceanu, Gabriela Negroiu, Daniela A Ion, Dragana Nikitovic, George N Tzanakakis, Demetrios A Spandidos, Aristidis M Tsatsakis
Regression in melanoma is a frequent biological event of uncertain prognostic value as the lesion exhibits heterogeneous phenotypical features, both at the morphological and immunohistochemical level. In the present study, we examined the expression of tissue inhibitors of metalloproteinases (TIMP1, TIMP2 and TIMP3) in melanoma with regression. We specifically examined the expression levels of these TIMPs in regressed components (RC) and non-regressed components (NRC) of the tumor and compared their expression levels with those in non-regressed melanomas...
May 2016: Oncology Letters
Mihaela A Ghita, Constantin Caruntu, Adrian E Rosca, Harillaq Kaleshi, Ana Caruntu, Liliana Moraru, Anca Oana Docea, Sabina Zurac, Daniel Boda, Monica Neagu, Demetrios A Spandidos, Aristidis M Tsatsakis
Superficial basal cell carcinoma (sBCC) is the second most frequent histological type of basal cell carcinoma (BCC), usually requiring a skin biopsy to confirm the diagnosis. It usually appears on the upper trunk and shoulders as erythematous and squamous lesions. Although it has a slow growth and seldom metastasizes, early diagnosis and management are of crucial importance in preventing local invasion and subsequent disfigurement. Dermoscopy is nowadays an indispensable tool for the dermatologist when evaluating skin tumors...
May 2016: Oncology Letters
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