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https://www.readbyqxmd.com/read/28498405/application-of-metabolomics-focus-on-the-quantification-of-organic-acids-in-healthy-adults
#1
Dimitris Tsoukalas, Athanasios Alegakis, Persefoni Fragkiadaki, Evangelos Papakonstantinou, Dragana Nikitovic, Aikaterini Karataraki, Alexander E Nosyrev, Emmanouel G Papadakis, Demetrios A Spandidos, Nikolaos Drakoulis, Aristides M Tsatsakis
Metabolomics, a 'budding' discipline, may accurately reflect a specific phenotype which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in science has been proposed as a tool for the evaluation of the effects of epigenetic factors, such as nutrition, environment, drug and lifestyle on phenotype. Urine, being sterile, is easy to obtain and as it contains metabolized or non‑metabolized products, is a favored study material in the field of metabolomics. Urine organic acids (OAs) reflect the activity of main metabolic pathways and have been used to assess health status, nutritional status, vitamin deficiencies and response to xenobiotics...
May 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28352339/determination-of-dna-damage-and-telomerase-activity-in-stanozolol-treated-rats
#2
Mehtap Kara, Eren Ozcagli, Persefoni Fragkiadaki, Tugba Kotil, Polychronis D Stivaktakis, Demetrios A Spandidos, Aristides M Tsatsakis, Buket Alpertunga
Anabolic androgenic steroids (AAS) are performance-enhancing drugs commonly abused by atheletes. Stanozolol is a synthetic testosterone-derived anabolic steroid. Although it is well known that AAS have several side-effects, there are only few toxicological studies available on the toxic effects and mechanisms of action of stanozolol. The aim of this study was to investigate the genotoxic effects of stanozolol and to determine its effects on telomerase activity in Sprague-Dawley male rats. For this purpose, 34 male rats were divided into 5 groups as follows: i) the control group (n=5); ii) the propylene glycol (PG)-treated group (n=5); iii) the stanozolol-treated group (n=8); iv) the PG-treated group subjected to exercise (n=8); and v) the stanozolol-treated group subjected to exercise (n=8)...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28352303/paediatric-virology-a-rapidly-increasing-educational-challenge
#3
Ioannis N Mammas, Maria Theodoridou, Anna Kramvis, Prakash Thiagarajan, Sharryn Gardner, Georgia Papaioannou, Angeliki Melidou, Maria Koutsaki, Georgia Kostagianni, Vassilis Achtsidis, Chryssie Koutsaftiki, Marcos Calachanis, Apostolos Zaravinos, Anne Greenough, Demetrios A Spandidos
The '2nd Workshop on Paediatric Virology', which took place on Saturday the 8th of October 2016 in Athens, Greece, provided an overview on recent views and advances on Paediatric Virology. Emphasis was given to HIV-1 management in Greece, a country under continuous financial crisis, hepatitis B vaccination in Africa, treatment options for hepatitis C virus in childhood, Zika virus in pregnancy and infancy, the burden of influenza on childhood, hand-foot-mouth disease and myocarditis associated with Coxsackie viruses...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28352302/the-development-of-the-paediatric-virology-study-group-ten-years-in-the-making
#4
EDITORIAL
Ioannis N Mammas, Maria Theodoridou, Demetrios A Spandidos
No abstract text is available yet for this article.
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28350123/design-synthesis-and-pharmaco-toxicological-assessment-of-5-mercapto-1-2-4-triazole-derivatives-with-antibacterial-and-antiproliferative-activity
#5
Marius Mioc, Codruta Soica, Vasile Bercean, Sorin Avram, Mihaela Balan-Porcarasu, Dorina Coricovac, Roxana Ghiulai, Delia Muntean, Florina Andrica, Cristina Dehelean, Demetrios A Spandidos, Aristides M Tsatsakis, Ludovic Kurunczi
The extensive biochemical research of multiple types of cancer has revealed important enzymatic signaling pathways responsible for tumor occurrence and progression, thus compelling the need for the discovery of new means with which to block these signaling cascades. The phosphoinositide 3-kinase/ protein kinase B (PI3K/AKT) pathway, which plays an important role in maintaining relevant cellular functions, exhibits various alterations in common human cancers, thus representing a suitable target in cancer treatment...
March 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28350110/glutamate%C3%A2-mediated-effects-of-caffeine-and-interferon%C3%A2-%C3%AE-on-mercury-induced-toxicity
#6
Ayse Basak Engin, Evren Doruk Engin, Kirill Golokhvast, Demetrios A Spandidos, Aristides M Tsatsakis
The molecular mechanisms mediating mercury‑induced neurotoxicity are not yet completely understood. Thus, the aim of this study was to investigate whether the severity of MeHg‑ and HgCl2‑mediated cytotoxicity to SH‑SY5Y human dopaminergic neurons can be attenuated by regulating glutamate‑mediated signal‑transmission through caffeine and interferon‑γ (IFN‑γ). The SH‑SY5Y cells were exposed to 1, 2 and 5 µM of either MeHgCl2 or HgCl2 in the presence or absence of L‑glutamine. To examine the effect of adenosine receptor antagonist, the cells were treated with 10 and 20 µM caffeine...
May 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28339065/the-risk-of-hcv-infection-among-health-care-workers-and-its-association-with-extrahepatic-manifestations-review
#7
Adriana Garozzo, Luca Falzone, Venerando Rapisarda, Andrea Marconi, Diana Cinà, Concettina Fenga, Demetrios A Spandidos, Massimo Libra
Health care workers (HCWs) are frequently exposed to different biological agents during their activities and are frequently monitored. Among these infectious agents, human hepatitis C (HCV) can infect HCWs. In this review article, the risk of HCV infection among HCWs is discussed along with extrahepatic HCV-related malignancies, such as non‑Hodgkin lymphoma. Accidental contamination, represented by percutaneous and mucocutaneous infections is the main risk factor for such infection. The compliance of the protection procedures, included in the current regulation for HCWs, is the most important issue to reduce the risk of pathogen infections that in turn may produce reduction of infection‑associated malignancies...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28292651/human-exposure-to-endocrine-disrupting-chemicals-effects-on-the-male-and-female-reproductive-systems
#8
REVIEW
Stavros Sifakis, Vasilis P Androutsopoulos, Aristeidis M Tsatsakis, Demetrios A Spandidos
Endocrine disrupting chemicals (EDCs) comprise a group of chemical compounds that have been examined extensively due to the potential harmful effects in the health of human populations. During the past decades, particular focus has been given to the harmful effects of EDCs to the reproductive system. The estimation of human exposure to EDCs can be broadly categorized into occupational and environmental exposure, and has been a major challenge due to the structural diversity of the chemicals that are derived by many different sources at doses below the limit of detection used by conventional methodologies...
March 6, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28260086/development-of-an-assay-to-assess-genotoxicity-by-particulate-matter-extract
#9
Alexandros Priftis, Konstantinos Papikinos, Marina Koukoulanaki, Efthalia Kerasioti, Dimitrios Stagos, Konstantinos Konstantinopoulos, Demetrios A Spandidos, Marianthi Kermenidou, Spyros Karakitsios, Dimosthenis Sarigiannis, Aristides M Tsatsakis, Demetrios Kouretas
The current study describes a method for assessing the oxidative potential of common environmental stressors (ambient air particulate matter), using a plasmid relaxation assay where the extract caused single-strand breaks, easily visualised through electrophoresis. This assay utilises a miniscule amount (11 µg) of particulate matter (PM) extract compared to other, cell‑based methods (~3,000 µg). The negative impact of air pollution on human health has been extensively recognised. Among the air pollutants, PM plays an eminent role, as reflected in the broad scientific interest...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28260009/molecular-profile-of-major-growth-factors-in-lumbar-intervertebral-disc-herniation-correlation-with-patient-clinical-and-epidemiological-characteristics
#10
Alexandros Tsarouhas, Giannoula Soufla, Konstantinos Tsarouhas, Pavlos Katonis, Dritan Pasku, Antonis Vakis, Aristides M Tsatsakis, Demetrios A Spandidos
The involvement of growth factors (GFs) in the pathogenesis of lumbar intervertebral disc (ID) herniation and the spontaneous resorption of herniated ID fragments remains only partially elucidated. A simultaneous assessment of the transcript levels of numerous GFs and their association with clinical and epidemiological profiles of human ID herniation would provide valuable insight into the biology and clinical course of the disease. In the present study, we examined simultaneously the transcript levels of vascular endothelial growth factor (VEGF), transforming growth factor β1 (TGF‑β1), basic fibroblast growth factor 2 (bFGF2), platelet derived growth factor (PDGF) isoforms and receptors, epidermal growth factor (EGF) and insulin growth factor‑1 (IGF‑1) in herniated and control ID specimens and investigated their correlation with the clinicopathological profiles of patients suffering from symptomatic lumbar ID herniation...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28212265/variations-in-oxidative-stress-levels-in-3-days-follow-up-in-ultramarathon-mountain-race-athletes
#11
Ypatios Spanidis, Dimitrios Stagos, Marina Orfanou, Nikolaos Goutzourelas, David Bar-Or, Demetrios Spandidos, Demetrios Kouretas
Spanidis, Y, Stagos, D, Orfanou, M, Goutzourelas, N, Bar-or, D, Spandidos, D, and Kouretas, D. Variations in oxidative stress levels in 3 days follow-up in ultramarathon mountain race athletes. J Strength Cond Res 31(3): 582-594, 2017-The aim of the present study was the monitoring of the redox status of runners participating in a mountain ultramarathon race of 103 km. Blood samples from 12 runners were collected prerace and 24, 48, and 72 hours postrace. The samples were analyzed by using conventional oxidative stress markers, such as protein carbonyls (CARB), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) in plasma, as well as glutathione (GSH) levels and catalase (CAT) activity in erythrocytes...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28105335/detection-of-stanozolol-in-the-urine-of-athletes-at-a-pg-level-the-possibility-of-passive-exposure
#12
Christina Tsitsimpikou, Konstantinos Tsarouhas, Demetrios A Spandidos, Aristides M Tsatsakis
Stanozolol is a synthetic heterocyclic steroid with anabolic and androgenic properties, which has been abused by several high-profile professional athletes. Stanozolol is also used in veterinary medicine to increase appetite, cause weight gain and treat certain types of anemia. The detection of stanozolol metabolites in human urine for doping control purposes depends on the analytical method applied. The most commonly applied methods in the World Anti-Doping Agency (WADA)-accredited doping control laboratories are gas chromatography/high-resolution mass spectrometry (GC/HRMS) or gas chromatography-mass spectrometry (GC/MS/MS)...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28075446/nf%C3%A2-%C3%AE%C2%BAb-inhibition-is-associated-with-opn-mmp%C3%A2-9-downregulation-in-cutaneous-melanoma
#13
COMPARATIVE STUDY
Claudio Guarneri, Valentina Bevelacqua, Jerry Polesel, Luca Falzone, Patrizia S Cannavò, Demetrios A Spandidos, Grazia Malaponte, Massimo Libra
The development of cutaneous melanoma is influenced by genetic factors, including BRAF mutations and environmental factors, such as ultraviolet exposure. Its progression has been also associated with the involvement of several tumour microenvironmental molecules. Among these, nuclear factor‑κB (NF‑κB) has been indicated as a key player of osteopontin (OPN) and matrix metalloproteinase‑9 (MMP‑9) activation. However, whether NF‑κB plays a role in the development and progression of melanoma in association with the OPN/MMP‑9 axis according to the BRAFV600E mutation status has not been investigated in detail to date...
February 2017: Oncology Reports
https://www.readbyqxmd.com/read/28005022/complex-interplay-of-dna-damage-dna-repair-genes-and-oxidative-stress-in-coronary-artery-disease
#14
EDITORIAL
Elena Vakonaki, Konstantinos Tsarouhas, Demetrios A Spandidos, Aristidis M Tsatsakis
No abstract text is available yet for this article.
December 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27959419/antimicrobial-resistance-development-following-surgical-site-infections
#15
Daniela Călina, Anca Oana Docea, Lucica Rosu, Ovidiu Zlatian, Alexandra Floriana Rosu, Florin Anghelina, Otilia Rogoveanu, Andreea Letiția Arsene, Alina Crenguța Nicolae, Cristina Manuela Drăgoi, John Tsiaoussis, Aristides M Tsatsakis, Demetrios A Spandidos, Nikolaos Drakoulis, Eliza Gofita
Surgical site infections (SSIs) determine an increase in hospitalization time and antibiotic therapy costs. The aim of this study was to identify the germs involved in SSIs in patients from the Clinical Emergency County Hospital of Craiova (SCJUC) and to assess their resistance to antimicrobials, with comparisons between surgical wards and the intensive care unit (ICU). The biological samples were subjected to classical bacteriological diagnostics. Antibiotic resistance was tested by disc diffusion. We used hierarchical clustering as a method to group the isolates based upon the antibiotic resistance profile...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27943100/k-ras-h-ras-n-ras-and-b-raf-mutation-and-expression-analysis-in-wilms-tumors-association-with-tumor-growth
#16
Efterpi Dalpa, Victor Gourvas, Nikolaos Soulitzis, Demetrios A Spandidos
Nephroblastoma (Wilms tumor) is a kidney neoplasia, predominately occurring at very young age, resulting from the malignant transformation of renal stem cells. The Ras proto-oncogenes and B-Raf are members of an intracellular cascade pathway, which regulates cell growth and differentiation, and ultimately cancer development. Our objective was to determine the mutation rate and to measure the mRNA levels of the three Ras genes and of B-Raf in formalin-fixed paraffin-embedded tissue samples from 32 patients with nephroblastoma and 10 controls...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/27909725/lipoprotein-redox-status-evaluation-as-a-marker-of-cardiovascular-disease-risk-in-patients-with-inflammatory-disease
#17
Anca Ungurianu, Denisa Margină, Daniela Grădinaru, Claudia Băcanu, Mihaela Ilie, Christina Tsitsimpikou, Konstantinos Tsarouhas, Demetrios A Spandidos, Aristides M Tsatsakis
Patients with chronic inflammatory disorders (ID) have an increased risk of developing cardiovascular disease, and routinely determined parameters do not reveal the real metabolic status of specific subgroups, such as patients with rheumatoid arthritis (RA). In this study, in order to evaluate state of the art markers for the assessment of cardiometabolic risk, abnormalities in lipoprotein levels in patients with a low‑grade inflammatory status [diabetes mellitus (DM) subgroup] and in patients with a high systemic inflammatory burden (RA subgroup) was determined...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27900005/fluoro-edenite-induces-fibulin-3-overexpression-in-non-malignant-human-mesothelial-cells
#18
Venerando Rapisarda, Rossella Salemi, Andrea Marconi, Carla Loreto, Adriana C Graziano, Venera Cardile, Maria S Basile, Saverio Candido, Luca Falzone, Demetrios A Spandidos, Concettina Fenga, Massimo Libra
Exposure to asbestos is associated with the development of mesothelioma. In addition to asbestos, other fibers have been identified as risk factors for malignant and non-malignant diseases of the lungs. Among these, fluoro-edenite (FE) was found in patients from Biancavilla (Sicily, Italy) with pleural and lung disease, suggesting its role for tumor expansion. In this context, the identification of early biomarkers useful for the diagnosis of cancer is mandatory. Fibulin-3 represents an important marker for the diagnosis of mesothelioma...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27769060/mir-185-akt-and-mir-29a-collagen-1a-pathways-are-activated-in-ipf-bal-cells
#19
Eliza Tsitoura, Athol U Wells, Kostantinos Karagiannis, Ismini Lasithiotaki, Eirini Vasarmidi, Eleni Bibaki, Chara Koutoulaki, Hiroe Sato, Demetrios A Spandidos, Nikolaos M Siafakas, George Sourvinos, Katerina M Antoniou
MicroRNA signatures of BAL cells and alveolar macrophages are currently lacking in IPF. Here we sought to investigate the expression of fibrosis-related microRNAs in the cellular component of the BAL in IPF. We thus focused on microRNAs previously associated with fibrosis (miR-29a, miR-29b, miR-29c, let-7d, and miR-21) and rapid IPF progression (miR-185, miR-210, miR-302c-3p miR-376c and miR-423-5p). Among the tested microRNAs miR-29a and miR-185 were found significantly downregulated in IPF while miR-302c-3p and miR-376c were not expressed by BAL cells...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27748930/mirnas-and-their-role-in-the-correlation-between-schizophrenia-and-cancer-review
#20
REVIEW
E Rizos, N Siafakas, E Skourti, C Papageorgiou, J Tsoporis, T H Parker, D I Christodoulou, D A Spandidos, E Katsantoni, V Zoumpourlis
Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is conversely characterized by an increase in appropriate molecular signaling that stimulates uncontrolled cell proliferation. The rather low risk of developing Ca in patients suffering from SZ is a hypothesis that is still under debate...
December 2016: Molecular Medicine Reports
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