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https://www.readbyqxmd.com/read/29097115/cytochrome-p450-cyp1-metabolism-of-hydroxylated-flavones-and-flavonols-selective-bioactivation-of-luteolin-in-breast-cancer-cells
#1
Nicola E Wilsher, Randolph R Arroo, Minos-Timotheos Matsoukas, Aristidis M Tsatsakis, Demetrios A Spandidos, Vasilis P Androutsopoulos
Natural flavonoids with methoxy substitutions are metabolized by CYP1 enzymes to yield the corresponding demethylated products. The present study aimed to characterize the metabolism and further antiproliferative activity of the hydroxylated flavonoids apigenin, luteolin, scutellarein, kaempferol and quercetin in CYP1 recombinant enzymes and in the CYP1 expressing cell lines MCF7 and MDA-MB-468, respectively. Apigenin was converted to luteolin and scutellarein, whereas kaempferol was metabolized only to quercetin by recombinant CYP1 enzymes...
October 31, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29042918/george-n-papanicolaou-1883-1962-an-exceptional-human-scientist-and-academic-teacher-an-interview-with-dr-neda-voutsa-perdiki
#2
Ioannis N Mammas, Demetrios A Spandidos
Dr Neda Voutsa-Perdiki, former Director of Exfoliative Cytology at the University of Florida (Florida, USA), talks about her academic teacher Dr George N. Papanicοlaou, referred to as the 'Father of Exfoliative Cytology', and his wife Mache, known as Mary Papanicolaou. According to Dr Voutsa-Perdiki, Dr Papanicolaou was an exceptional teacher and a unique humanitarian in modern medical history. The secret of his scientific success was hard work, dedication, love of research, faith and the courage he gained from his wife and colleagues...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042917/viral-infections-neonatal-mortality-and-the-mystery-of-the-athenian-agora-an-interview-with-professor-of-anthropology-maria-liston
#3
Ioannis N Mammas, Demetrios A Spandidos
Although excavated almost 80 years ago, the infants' 'bone well' of the Athenian Agora in Athens, Greece and its contents were never thoroughly evaluated and published, until only recently, when a re-analysis of the whole excavation findings was performed. The well dates back to the third quarter of the 2nd century BC and contained at least 449 infants. The project, which explored the causes of neonatal mortality, found that one-third of infants' deaths were attributed to neonatal meningitis, based on the presence of bone disposition on the endocranial surface of the studied skulls...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042916/the-proposal-of-paediatric-virology-and-its-perspectives-an-interview-with-professor-of-paediatrics-maria-theodoridou
#4
Ioannis N Mammas, Demetrios A Spandidos
Professor Maria Theodoridou, Emeritus Professor of Paediatrics at the University of Athens, is one of the few paediatricians in Greece, who have experienced almost all the infectious diseases of the second half of the 20th century and their severe consequences, prior to the widespread adoption of immunisations. A milestone during her career was the establishment of a specialised National Reference Unit for the care of paediatric patients with acquired immune deficiency syndrome (AIDS) at the 'Aghia Sophia' Children's Hospital in Athens, Greece...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042915/the-innovation-of-the-subspecialty-of-paediatric-virology-an-interview-with-research-professor-of-molecular-virology-anna-kramvis
#5
Ioannis N Mammas, Demetrios A Spandidos
Professor Anna Kramvis, Research Professor of Molecular Virology at the University of the Witwatersrand in Johannesburg, South Africa, talks about direct-acting antiviral treatments against hepatitis C virus (HCV), as well as the perspective of the development of an effective vaccine against HCV. She emphasises the necessity of vaccination against hepatitis B virus (HBV), highlighting that it is very important that vaccination should be administered at birth in order to prevent mother-to-child transmission (MTCT) of HBV...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042914/the-educational-challenge-of-paediatric-virology-an-interview-with-professor-of-neonatology-anne-greenough
#6
Ioannis N Mammas, Demetrios A Spandidos
According to Professor Anne Greenough, Professor of Neonatology and Clinical Respiratory Physiology at the King's College London (London, UK), Paediatric Virology is indeed a rapidly increasing educational challenge. Professor Greenough, who in 1992 wrote her book on congenital, perinatal and neonatal infections, believes that during the past 3 decades, paediatric health professionals are becoming increasingly involved in specialised care and follow-up of paediatric patients with viral diseases, who require advanced medical care and innovative technological services...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042913/paediatric-virology-as-a-new-educational-initiative-an-interview-with-nobelist-professor-of-virology-harald-zur-hausen
#7
Ioannis N Mammas, Demetrios A Spandidos
Born in Gelsenkirchen-Buer in Germany on March 11th, 1936, Professor Harald zur Hausen, Emeritus Professor of Virology at the University of Freiburg and 2008 Nobel Prize Laureate in Physiology or Medicine for his discovery of human papillomavirus (HPV), which causes cervical cancer, believes that good knowledge of virological methods and diagnostic possibilities are an asset for all young paediatricians. Professor zur Hausen considers that the creation of an educational platform on Paediatric Virology is definitely very beneficial for young paediatricians, as this will greatly enhance their knowledge in the field of Virology...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042912/hpv-vaccination-in-boys-determining-the-clinical-relevance-of-this-strategy
#8
EDITORIAL
Harald Zur Hausen, Ioannis N Mammas, Demetrios A Spandidos
No abstract text is available yet for this article.
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29039613/staphylococcus-aureus-colonisation-in-patients-from-a-primary-regional-hospital
#9
Anca Ungureanu, Ovidiu Zlatian, George Mitroi, Andrei Drocaş, Tiberiu Ţîrcă, Daniela Călina, Cristina Dehelean, Anca Oana Docea, Boris N Izotov, Valerii N Rakitskii, Ramona Cioboată, Demetrios A Spandidos, Aristides M Tsatsakis, Alice Găman
Staphylococcus aureus (SA or S. aureus) is a common pathogen that leads to local and systemic infections in communitarian and hospitalised patients. Staphylococcus colonizing nasal or pharyngeal sites can become virulent and cause severe infections. In this study, we collected 322 pharyngeal exudates and 142 nasal exudates from hospitalised and outpatients for screening purposes. The carriage rates in the pharynx were 27.06% for S. aureus, 11.55% for methicillin‑resistant S. aureus (MRSA) and 5.61% for methicillin‑oxacillin resistant S...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039546/antiproliferative-effects-of-tsa-pxd%C3%A2-101-and-ms%C3%A2-275-in-a2780-and-mcf7-cells-acetylated-histone-h4-and-acetylated-tubulin-as-markers-for-hdaci-potency-and-selectivity
#10
Vasilis P Androutsopoulos, Demetrios A Spandidos
Inhibition of histone deacetylase enzymes (HDACs) has been well documented as an attractive target for the development of chemotherapeutic drugs. The present study investigated the effects of two prototype hydroxamic acid HDAC inhibitors, namely Trichostatin A (TSA) and Belinostat (PXD‑101) and the benzamide Entinostat (MS‑275) in A2780 ovarian carcinoma and MCF7 breast adenocarcinoma cells. The three HDACi inhibited the proliferation of A2780 and MCF7 cells at comparable levels, below the µM range. Enzyme inhibition assays in a cell‑free system showed that TSA was the most potent inhibitor of total HDAC enzyme activity followed by PXD‑101 and MS‑275...
October 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039461/effects-of-ursolic-and-oleanolic-on-sk%C3%A2-mel%C3%A2-2-melanoma-cells-in%C3%A2-vitro-and-in%C3%A2-vivo-assays
#11
Angela Caunii, Camelia Oprean, Mirabela Cristea, Alexandra Ivan, Corina Danciu, Calin Tatu, Virgil Paunescu, Daniela Marti, George Tzanakakis, Demetrios A Spandidos, Aristides Tsatsakis, Razvan Susan, Codruta Soica, Stefana Avram, Cristina Dehelean
Among the triterpenoids, oleanolic acid (OA) and its isomer, ursolic acid (UA) are promising therapeutic candidates, with potential benefits in the management of melanoma. In this study, we aimed to examine the in vitro and in vivo anti‑invasive and anti‑metastatic activity of OA and UA to determine their possible usefulness as chemopreventive or chemotherapeutic agents in melanoma. For the in vitro experiments, the anti‑proliferative activity of the triterpenic compounds on SK‑MEL‑2 melanoma cells was examined...
December 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29029543/the-mir-200-family-in-ovarian-cancer
#12
REVIEW
Maria Koutsaki, Massimo Libra, Demetrios A Spandidos, Apostolos Zaravinos
Ovarian cancer (OC) is the most lethal gynecological malignancy. Its insidious nature, manifesting with little to no symptoms until the disease progresses to metastasis, along with a wide diversity of histological subtypes and corresponding clinical behavior, poses significant therapeutic challenges. The genetic profiling of this aggressive tumor and its subtypes has led to the identification of various molecular markers of prognosis. Among these, the miR-200 family of miRNAs appears to play an important role...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28990043/%C3%AE-he-genetics-of-juvenile-idiopathic-arthritis-searching-for-new-susceptibility-loci
#13
Maria I Zervou, Despoina G Dimopoulou, Elias Eliopoulos, Maria Trachana, Polyxeni Pratsidou-Gkertsi, Athena Andreou, Prodromos Sidiropoulos, Demetrios A Spandidos, Alexandros Garyfallos, George N Goulielmos
Juvenile idiopathic arthritis (JIA) is an autoimmune disease that is characterized by persistent chronic arthritis and affected by genetic and environmental factors. Different genetic variations have been reported as risk factors for JIA. However, given that many results could not be replicated in individuals of different ancestral origin, it was assumed that heterogeneous genetic factors are involved in this disease. In the present study, we analyzed three single nucleotide polymorphisms (SNPs), namely PTPRC (rs10919563), TYK2 (rs34536443) and PRKCQ (rs4750316), which were found to be associated with JIA in previous studies...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28901453/the-role-of-gene-polymorphisms-in-endometriosis
#14
Michail Matalliotakis, Maria I Zervou, Charoula Matalliotaki, Nilufer Rahmioglu, George Koumantakis, Ioannis Kalogiannidis, Ioannis Prapas, Krina Zondervan, Demetrios A Spandidos, Ioannis Matalliotakis, George N Goulielmos
Endometriosis is a benign gynecologic disorder, affecting up to 10% of women, characterized by the presence of functional endometrial tissue at ectopic positions generally within the peritoneum. It is a heritable condition influenced by multiple genetic and environmental factors, with an overall heritability estimated at approximately 50%. In this study, we investigated whether single nucleotide polymorphisms (SNPs) rs7521902, rs10859871 and rs11031006, mapping to WNT4, VEZT and FSHB genetic loci, respectively, are associated with risk for endometriosis in a Greek population...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28765873/classification-of-cancer-cell-lines-using-matrix-assisted-laser-desorption-ionization-time%C3%A2-of%C3%A2-flight-mass-spectrometry-and-statistical-analysis
#15
Vlad Serafim, Ajit Shah, Maria Puiu, Nicoleta Andreescu, Dorina Coricovac, Alexander Nosyrev, Demetrios A Spandidos, Aristides M Tsatsakis, Cristina Dehelean, Iulia Pinzaru
Over the past decade, matrix-assisted laser desorption/ionization time‑of‑flight mass spectrometry (MALDI‑TOF MS) has been established as a valuable platform for microbial identification, and it is also frequently applied in biology and clinical studies to identify new markers expressed in pathological conditions. The aim of the present study was to assess the potential of using this approach for the classification of cancer cell lines as a quantifiable method for the proteomic profiling of cellular organelles...
October 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28731131/assessment-of-the-antioxidant-activity-of-an-olive-oil-total-polyphenolic-fraction-and-hydroxytyrosol-from-a-greek-olea%C3%A2-europea-variety-in-endothelial-cells-and-myoblasts
#16
Paraskevi Kouka, Alexandros Priftis, Dimitrios Stagos, Apostolis Angelis, Panagiotis Stathopoulos, Nikos Xinos, Alexios-Léandros Skaltsounis, Charalampos Mamoulakis, Aristides M Tsatsakis, Demetrios A Spandidos, Demetrios Kouretas
Olive oil (OO) constitutes the basis of the Mediterranean diet, and it seems that its biophenols, such as hydroxytyrosol (HT) may scavenge free radicals, attracting distinct attention due to their beneficial effects in many pathological conditions, such as cancer. To the best of our knowedge, this is the first study in which the functional properties of an OO total polyphenolic fraction (TPF) and pure HT were examined in order to determine their antioxidant effects at a cellular level in endothelial cells and myoblasts...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28713981/neuroendocrine-factors-the-missing-link-in-non%C3%A2-melanoma-skin-cancer-review
#17
Mihai Lupu, Ana Caruntu, Constantin Caruntu, Laura Maria Lucia Papagheorghe, Mihaela Adriana Ilie, Vlad Voiculescu, Daniel Boda, Carolina Constantin, Cristiana Tanase, Maria Sifaki, Nikolaos Drakoulis, Charalampos Mamoulakis, George Tzanakakis, Monica Neagu, Demetrios A Spandidos, Boris N Izotov, Aristides M Tsatsakis
Non‑melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun‑protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Arising primarily on sun‑exposed skin, it has been shown that ultraviolet radiation is, in the majority of cases, the main trigger involved in the pathogenesis of NMSC...
September 2017: Oncology Reports
https://www.readbyqxmd.com/read/28713957/soyasaponin%C3%A2-ag-inhibits-%C3%AE-%C3%A2-msh%C3%A2-induced-melanogenesis-in-b16f10-melanoma-cells-via-the-downregulation-of-trp%C3%A2-2
#18
Seung Hwan Yang, Aristides M Tsatsakis, George Tzanakakis, Hong-Suk Kim, Bao Le, Maria Sifaki, Demetrios A Spandidos, Chigen Tsukamoto, Kirill S Golokhvast, Boris N Izotov, Gyuhwa Chung
Saponins, which are glycosylated, represent a diverse group of biologically functional products in plants. In the present study, we investigated the effects of soyasaponin Ag, a secondary metabolite extracted from soybean, on α‑melanocyte-stimulating hormone (α‑MSH)‑induced melanin synthesis in B16F10 mouse melanoma cells and the underlying molecular mechanisms. To elucidate the mechanisms through which soyasaponin Ag inhibits melanin synthesis, we performed cellular tyrosinase activity assays and analyzed the expression of the melanogenesis‑related genes, tyrosinase, tyrosinase‑related protein (TRP)‑1 and TRP‑2...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28677813/anticancer-and-apoptosis%C3%A2-inducing-effects-of-quercetin-in-vitro-and-in-vivo
#19
Mahmoud Hashemzaei, Amin Delarami Far, Arezoo Yari, Reza Entezari Heravi, Kaveh Tabrizian, Seyed Mohammad Taghdisi, Sarvenaz Ekhtiari Sadegh, Konstantinos Tsarouhas, Dimitrios Kouretas, George Tzanakakis, Dragana Nikitovic, Nikita Yurevich Anisimov, Demetrios A Spandidos, Aristides M Tsatsakis, Ramin Rezaee
The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 µM was assessed in vitro by MMT assay in 9 tumor cell lines (colon carcinoma CT‑26 cells, prostate adenocarcinoma LNCaP cells, human prostate PC3 cells, pheocromocytoma PC12 cells, estrogen receptor‑positive breast cancer MCF‑7 cells, acute lymphoblastic leukemia MOLT‑4 T‑cells, human myeloma U266B1 cells, human lymphoid Raji cells and ovarian cancer CHO cells)...
August 2017: Oncology Reports
https://www.readbyqxmd.com/read/28643945/athens-based-meeting-to-discuss-the-paediatric-virology-crossroad-in-october-2017
#20
LETTER
Ioannis N Mammas, Demetrios A Spandidos
No abstract text is available yet for this article.
June 23, 2017: Acta Paediatrica
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