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https://www.readbyqxmd.com/read/29749429/antibacterial-and-antioxidant-activity-of-different-types-of-honey-derived-from-mount-olympus-in-greece
#1
Dimitrios Stagos, Nikolaos Soulitsiotis, Christina Tsadila, Stamatina Papaeconomou, Charalampos Arvanitis, Alexandros Ntontos, Fani Karkanta, Soultana Adamou-Androulaki, Konstantinos Petrotos, Demetrios A Spandidos, Demetrios Kouretas, Dimitris Mossialos
The aim of the present study was to examine the antioxidant and antibacterial activity of 21 types of honey derived from Mount Olympus (Mt. Olympus), a region with great plant biodiversity. The antibacterial activity was examined against the growth of Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) by the agar well diffusion assay and the determination of the minimum inhibitory concentration (MIC). The antioxidant activity was assessed by using the 2,2‑diphenyl‑1‑picrylhydrazyl (DPPH) and 2,2'‑azino‑bis(3‑ethylbenzothiazoline‑6‑sulphonic acid (ABTS•+) free radical scavenging assays...
May 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29732146/oxidative-stress-and-kidney-injury-in-trans-radial-catheterization
#2
Konstantinos Tsarouhas, Christina Tsitsimpikou, Xrisoula Papantoni, Dimitra Lazaridou, Michael Koutouzis, Savvas Mazzaris, Ramin Rezaee, Charalambos Mamoulakis, Panagiotis Georgoulias, Charitini Nepka, Elias Rentoukas, Zenon Kyriakides, Aristidis Tsatsakis, Demetrios A Spandidos, Demetrios Kouretas
Oxidative stress is linked to coronary artery disease and is a major mechanism in contrast-induced nephropathy. Trans-radial approach in coronary angiography (CA) with minimized peri-procedural bleeding is expected to reduce acute kidney injury incidence. In the present study, oxidative stress patterns observed in radial CA and their associations with early manifestations of kidney injury are described. A total of 20 stable coronary disease patients submitted to CA and 17 sex-matched patients undergoing computed tomography for myoskeletal reasons were enrolled...
May 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29725467/association-between-ovarian-cancer-and-advanced-endometriosis
#3
Michail Matalliotakis, Charoula Matalliotaki, George N Goulielmos, Evridiki Patelarou, Maria Tzardi, Demetrios A Spandidos, Aydin Arici, Ioannis Matalliotakis
We retrospectively analyzed clinicopathological data in two different countries over the past years on the association between ovarian endometriosis and ovarian carcinoma. Medical and pathological reports were evaluated from 1,000 patients with endometriosis from two different geographical areas. The prevalence and women characteristics of cases were analyzed. Endometriosis-associated ovarian cancer was present in 20 (2%) cases, among the study subjects. The observed prevalence was 12 (60%) for endometrioid carcinoma, 4 (20%) for clear cell ovarian carcinoma, 2 (10%) for serous and 2 (10%) for mucinous adenocarcinoma...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29717770/stanozolol-administration-combined-with-exercise-leads-to-decreased-telomerase-activity-possibly-associated-with-liver-aging
#4
Eren Ozcagli, Mehtap Kara, Tugba Kotil, Persefoni Fragkiadaki, Manolis N Tzatzarakis, Christina Tsitsimpikou, Polychronis D Stivaktakis, Dimitrios Tsoukalas, Demetrios A Spandidos, Aristides M Tsatsakis, Buket Alpertunga
Anabolic agents are doping substances which are commonly used in sports. Stanozolol, a 17α‑alkylated derivative of testosterone, has a widespread use among athletes and bodybuilders. Several medical and behavioral adverse effects are associated with anabolic androgenic steroids (AAS) abuse, while the liver remains the most well recognized target organ. In the present study, the hepatic effects of stanozolol administration in rats at high doses resembling those used for doping purposes were investigated, in the presence or absence of exercise...
April 26, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29693701/cell%C3%A2-specific-and-roasting%C3%A2-dependent-regulation-of-the-keap1-nrf2-pathway-by-coffee-extracts
#5
Alexandros Priftis, Antonia-Eugenia Angeli-Terzidou, Aristidis S Veskoukis, Demetrios A Spandidos, Dimitrios Kouretas
Coffee is a popular beverage that contains various bioactive compounds. However, its molecular mechanism of action is not fully elucidated. In this context, two previously characterized coffee extracts, a lightly roasted and the corresponding green one, were investigated for their effect on nuclear factor erythroid 2‑related factor 2 (Nrf2) target gene expression in myoblasts and endothelial cells using quantitative PCR. The tested concentrations were non‑cytotoxic and led to improved redox cell status, as was evident by increased reduced glutathione (GSH) levels...
April 24, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29620235/toxicity-of-plant-extracts-containing-pyrrolizidine-alkaloids-using-alternative-invertebrate-models
#6
Oana Cristina Seremet, Octavian Tudorel Olaru, Claudia Maria Gutu, George Mihai Nitulescu, Mihaela Ilie, Simona Negres, Cristina Elena Zbarcea, Carmen Nicoleta Purdel, Demetrios A Spandidos, Aristides M Tsatsakis, Michael D Coleman, Denisa Marilena Margina
Pyrrolizidine alkaloids (PAs) are a widespread class of hepatotoxic heterocyclic organic compounds found in approximately 3% of world flora. Some PAs have been shown to have genotoxic and carcinogenic effects. The present study focuses on the toxicity effects of four dry extracts obtained from medicinal plants (Senecio vernalis, Symphytum officinale, Petasites hybridus and Tussilago farfara), on two aquatic organisms, Artemia salina and Daphnia magna, and the correlation with their PAs content. A new GC‑MS method, using a retention time (TR)‑5MS type capillary column was developed...
March 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29620159/foxp3-expression-is-modulated-by-tgf%C3%A2-%C3%AE-1-notch1-pathway-in-human-melanoma
#7
Eva Skarmoutsou, Valentina Bevelacqua, Fabio D' Amico, Angela Russo, Demetrios A Spandidos, Aurora Scalisi, Grazia Malaponte, Claudio Guarneri
Forkhead box protein 3 (FOXP3) transcription factor is expressed by immune cells and several human cancers and is associated with tumor aggressiveness and unfavorable clinical outcomes. NOTCH and transforming growth factor‑β (TGF‑β) protumorigenic effects are mediated by FOXP3 expression in several cancer models; however, their interaction and role in melanoma is unknown. We investigated TGF‑β‑induced FOXP3 gene expression during NOTCH1 signaling inactivation. Primary (WM35) and metastatic melanoma (A375 and A2058) cell lines and normal melanocytes (NHEM) were used...
April 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29616085/assessment-of-telomerase-activity-in-leukocytes-of-type-2-diabetes-mellitus-patients-having-or-not-foot-ulcer-possible-correlation-with-other-clinical-parameters
#8
Dimitrios Baltzis, Evangelia Meimeti, Maria G Grammatikopoulou, Matthieu Roustit, Eleni Mavrogonatou, Dimitris Kletsas, Smaragda Efraimidou, Christos Manes, Taxiarchis K Nikolouzakis, John Tsiaoussis, Aristides M Tsatsakis, Demetrios A Spandidos, Christina-Maria Trakatelli, Nikolaos Drakoulis
Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mellitus (T2DM) were studied. Patients were allocated into two groups according to the absence or presence of active foot ulcers as follows: Νon-ulcer group (N=58) and ulcer group (N=32)...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29604107/the-1918-spanish-flu-outbreak-that-devastated-a-greek-island-underlines-past-lessons-that-must-never-be-forgotten
#9
Ioannis N Mammas, Maria Theodoridou, Demetrios A Spandidos
This year marks the 100th anniversary of the outbreak of Spanish flu, which is estimated to have killed more than 50 million people worldwide. One area that was devastated was the Aegean island of Skyros, where the first cases appeared following celebrations for the feast day of Saint Demetrios at the end of October 1918. The island, which is the largest and southernmost island of the Northern Sporades, had 3,200 residents and one-third of the 3,000 people who were infected died (1). This article is protected by copyright...
March 31, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29568927/mir-185-and-mir-29a-are-similarly-expressed-in-the-bronchoalveolar-lavage-cells-in-ipf-and-lung-cancer-but-common-targets-dnmt1-and-col1a1-show-disease-specific-patterns
#10
Eleni Bibaki, Eliza Tsitoura, Eirini Vasarmidi, George Margaritopoulos, Athina Trachalaki, Chara Koutoulaki, Theodora Georgopoulou, Demetrios A Spandidos, Nikos Tzanakis, Katerina M Antoniou
Idiopathic pulmonary fibrosis (IPF) and lung cancer (LC) constitute two progressively devastating lung diseases with common risk factors including aging and smoking. There is an increasing interest in the investigation of common pathogenic mechanisms between IPF and LC with therapeutic implications. Several oncomirs, microRNAs associated with malignancy, are also linked with IPF. miR‑29a and miR‑185 downregulation is probably involved both in carcinogenesis and fibrogenesis. We have previously observed miR‑29a and miR‑185 downregulation in IPF cells from bronchoalveolar lavage (BAL) and in this study we investigated their expression in LC BAL cells...
March 19, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29565457/improving-diagnosis-prognosis-and-prediction-by-using-biomarkers-in-crc-patients-review
#11
Taxiarchis Konstantinos Nikolouzakis, Loukia Vassilopoulou, Persefoni Fragkiadaki, Theodoros Mariolis Sapsakos, George Papadakis, Demetrios A Spandidos, Aristides M Tsatsakis, John Tsiaoussis
Colorectal cancer (CRC) is among the most common cancers. In fact, it is placed in the third place among the most diagnosed cancer in men, after lung and prostate cancer, and in the second one for the most diagnosed cancer in women, following breast cancer. Moreover, its high mortality rates classifies it among the leading causes of cancer‑related death worldwide. Thus, in order to help clinicians to optimize their practice, it is crucial to introduce more effective tools that will improve not only early diagnosis, but also prediction of the most likely progression of the disease and response to chemotherapy...
March 21, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29556380/clinical-applications-of-mesenchymal-stem-cells-in-chronic-lung-diseases
#12
Katerina M Antoniou, Konstantinos Karagiannis, Eliza Tsitoura, Eleni Bibaki, Ismini Lasithiotaki, Athanasia Proklou, Demetrios A Spandidos, Nikos Tzanakis
Mesenchymal stem (stromal) cells (MSCs) are multipotent stromal cells that have the ability to modulate immune response to tissue injury and promote repair in vivo . The therapeutic potential of ex vivo expanded MSCs are currently under investigation for a variety of chronic and acute lung diseases. This review summarizes the encouraging results regarding the safety of MSCs administration from recent and current clinical trials for idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and chronic obstructive pulmonary disease...
April 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29556256/spinal-muscular-atrophy-type-i-and-the-dual-role-of-viruses-an-interview-with-professor-basil-t-darras-professor-of-neurology-pediatrics-at-harvard-medical-school
#13
Ioannis N Mammas, Demetrios A Spandidos
According to Professor Basil T. Darras, Professor of Neurology (Pediatrics) at Harvard Medical School and Director of the Spinal Muscular Atrophy (SMA) Program at Boston Children's Hospital in Boston (MA, USA), the diagnosis of SMA type I is clinical and is based on detailed general physical and neurological examinations. SMA type I remains the most common genetic disease resulting in death in infancy and is really devastating for the child, the parents, as well as the medical professionals with the privilege of caring for patients with SMA and their parents...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29556255/spinal-muscular-atrophy-pediatric-virology-and-gene-therapy-a-challenge-of-modern-weakness-and-hope
#14
EDITORIAL
Basil T Darras, Ioannis N Mammas, Demetrios A Spandidos
No abstract text is available yet for this article.
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29532882/placental-expression-of-pappa-pappa-2-and-plac-1-in-pregnacies-is-associated-with-fgr
#15
Stavros Sifakis, Vasilis P Androutsopoulos, Artemis Pontikaki, Alexis Velegrakis, George I Papaioannou, Ourania Koukoura, Demetrios A Spandidos, Nikos Papantoniou
Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0...
March 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29532857/cutaneous-melanoma-from-pathogenesis-to-therapy-review
#16
Giulia C Leonardi, Luca Falzone, Rossella Salemi, Antonino Zanghì, Demetrios A Spandidos, James A Mccubrey, Saverio Candido, Massimo Libra
In less than 10 years, melanoma treatment has been revolutionized with the approval of tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to have a significant impact on the prognosis of patients with melanoma. The early steps of this transformation have taken place in research laboratories. The mitogen‑activated protein kinase (MAPK) pathway, phosphoinositol‑3‑kinase (PI3K) pathway promote the development of melanoma through numerous genomic alterations on different components of these pathways...
April 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29484396/effects-of-sheep-goat-whey-protein-dietary-supplementation-on-the-redox-status-of-rats
#17
Efthalia Kerasioti, Dimitrios Stagos, Aristides M Tsatsakis, Demetrios A Spandidos, Ioannis Taitzoglou, Demetrios Kouretas
The purpose of the present study is to estimate the effects of sheep/goat whey protein dietary supplementation on the redox status of blood and tissues of rats. Twelve male Wistar rats were divided into the control group (standard commercial diet) and whey group [standard commercial diet + sheep/goat whey protein (1 g kg b.w/day)] (6 rats/group). The animals were maintainted on their respective diet for 28 days. At the end of the experimental period, reduced glutathione, catalase activity, total antioxidant capacity, thiobarbituric reactive substances, protein carbonyls and the decomposition rate of H2O2 were measured in blood and tissues of rats...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29435275/safe-use-of-chemicals-by-professional-users-and-health-care-specialists
#18
Margarita Apatsidou, Ioanna Konstantopoulou, Eleni Foufa, Konstantinos Tsarouhas, Petros Papalexis, Ramin Rezaee, Demetrios A Spandidos, Demetrios Kouretas, Christina Tsitsimpikou
The awareness of Greek professional users and health care specialists regarding the safe use of chemicals was investigated, to be the best of our knowledge, for the first time after the introduction of Regulations (EC) 1907/2006 (REACH) and 1272/2008 (CLP) on chemicals. A total of 200 professional users and 150 health care specialists from various regions of Greece contributed to the use of a closed-ended, anonymous and validated questionnaire. The findings showed that over 85% of the responders were not aware of classification, labelling and packaging (CLP) and 67...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29435268/common-mental-disorders-and-association-with-telomere-length
#19
E Vakonaki, K Tsiminikaki, S Plaitis, P Fragkiadaki, D Tsoukalas, I Katsikantami, G Vaki, M N Tzatzarakis, D A Spandidos, A M Tsatsakis
Telomeres are repeated 5'-TTAGGG-3' sequences at the end of chromosomes, which maintain genomic stability. Their length is related to a number of diseases that affect humans. Apart from cancer, cardiovascular diseases, diabetes and other, telomere length has been associated with chronic diseases. Chronic mental illness includes various types of mental disorders with the most common being depression, schizophrenia and stress-anxiety. The aim of this review is to summarize the current state of knowledge on the role of telomeres in these disorders and to compare telomere length variations in patients receiving medication and patients not taking treatment...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29434846/co-existence-of-benign-gynecological-tumors-with-endometriosis-in-a-group-of-1-000-women
#20
Charoula Matalliotaki, Michail Matalliotakis, Panagiotis Ieromonachou, George N Goulielmos, Maria I Zervou, Aggelos Laliotis, Demetrios A Spandidos, Aydin Arici, Ioannis Matalliotakis
The purpose of this study was two-fold, first to investigate the association between endometriosis and the risk of benign gynecologic tumors and, secondly, to evaluate the distribution of endometrioma and ovarian cysts in women with endometriosis. The medical and pathological reports of 1,000 women with endometriosis were retrospectively reviewed. The incidence of ovarian cysts, uterine leiomyomas and adenomyosis, as well as the side of ovarian cysts were further compared. A total of 295 cases of endometriomas, 172 cases of adenomyosis, 173 cases of ovarian cysts and 89 cases of uterine leiomyomas were confirmed histologically in patients with endometriosis...
February 2018: Oncology Letters
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