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https://www.readbyqxmd.com/read/29348831/aberrant-expression-of-mir-21-mir-376c-and-mir-145-and-their-target-host-genes-in-merkel-cell-polyomavirus-positive-non-small-cell-lung-cancer
#1
Ismini Lasithiotaki, Eliza Tsitoura, Anastasios Koutsopoulos, Eleni Lagoudaki, Chara Koutoulaki, George Pitsidianakis, Demetrios A Spandidos, Nikolaos M Siafakas, George Sourvinos, Katerina M Antoniou
Merkel Cell Polyoma Virus (MCPyV) infection has been associated with non-small cell lung cancer (NSCLC). Viruses can manipulate cellular miRNAs or have a profound impact on cellular miRNA expression to control host regulatory pathways. In this study, we evaluated the expression profiles of cancer-associated and virally affected host microRNAs miR-21, miR-145, miR-146a, miR-155, miR-302c, miR-367 and miR-376c in a series of NSCLC tissue samples as well as in samples from "healthy" sites, distant from the tumour region that were either positive or negative for MCPyV DNA...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29344129/update-on-radionuclide-therapy-in-oncology
#2
Cornelia Nitipir, Dana Niculae, Cristina Orlov, Maria Alexandra Barbu, Bogdan Popescu, Ana Maria Popa, Anca Mihaela Stoian Pantea, Adina Elena Stanciu, Bianca Galateanu, Octav Ginghina, Georgios Z Papadakis, Boris N Izotov, Demetrios A Spandidos, Aristides M Tsatsakis, Carolina Negrei
Unstable isotopes and their capacity to emit ionizing radiation have been employed in clinical practice not only for diagnostic, but also for therapeutic purposes, with significant contribution in several fields of medicine and primarily in the management of oncologic patients. Their efficacy is associated with their ability to provide the targeted delivery of ionizing radiation for a determined duration. These compounds can be used for curative or palliative treatment, as well as for a diagnostic-therapeutic (theranostic) approach...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29328393/paediatric-virology-and-its-interaction-between-basic-science-and-clinical-practice-review
#3
Ioannis N Mammas, Anne Greenough, Maria Theodoridou, Anna Kramvis, Maria Rusan, Angeliki Melidou, Paraskevi Korovessi, Georgia Papaioannou, Alexia Papatheodoropoulou, Chryssie Koutsaftiki, Maria Liston, George Sourvinos, Demetrios A Spandidos
The 3rd Workshop on Paediatric Virology, which took place on October 7th, 2017 in Athens, Greece, highlighted the role of breast feeding in the prevention of viral infections during the first years of life. Moreover, it focused on the long-term outcomes of respiratory syncytial virus and rhinovirus infections in prematurely born infants and emphasised the necessity for the development of relevant preventative strategies. Other topics that were covered included the vaccination policy in relation to the migration crisis, mother‑to‑child transmission of hepatitis B and C viruses, vaccination against human papilloma viruses in boys and advances on intranasal live‑attenuated vaccination against influenza...
January 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29328375/the-role-of-il%C3%A2-16-gene-polymorphisms-in-endometriosis
#4
Michail Matalliotakis, Maria I Zervou, Elias Eliopoulos, Charoula Matalliotaki, Nilufer Rahmioglu, Ioannis Kalogiannidis, Krina Zondervan, Demetrios A Spandidos, Ioannis Matalliotakis, George N Goulielmos
Endometriosis is one of the most common gynecological diseases affecting up to 10% of the female population of childbearing age and a major cause of pain and infertility. It is influenced by multiple genetic, epigenetic and environmental factors. Interleukin‑16 (IL‑16) is a proinflammatory cytokine playing a pivotal role in many inflammatory and autoimmune diseases as well as in the pathogenesis of endometriosis. The aim of the present study was to evaluate the association of two IL‑16 gene single nucleotide polymorphisms (SNPs), rs4072111 and rs11556218, with the risk of endometriosis in women from Greece as well as to gain insight about the structural consequences of these two exonic SNPs regarding development of the disease...
January 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29328364/genetically%C3%A2-modified-stem-cells-in-treatment-of-human-diseases-tissue-kallikrein-klk1-%C3%A2-based-targeted-therapy-review
#5
Marina Devetzi, Maria Goulielmaki, Nicolas Khoury, Demetrios A Spandidos, Georgia Sotiropoulou, Ioannis Christodoulou, Vassilis Zoumpourlis
The tissue kallikrein‑kinin system (KKS) is an endogenous multiprotein metabolic cascade which is implicated in the homeostasis of the cardiovascular, renal and central nervous system. Human tissue kallikrein (KLK1) is a serine protease, component of the KKS that has been demonstrated to exert pleiotropic beneficial effects in protection from tissue injury through its anti‑inflammatory, anti‑apoptotic, anti‑fibrotic and anti‑oxidative actions. Mesenchymal stem cells (MSCs) or endothelial progenitor cells (EPCs) constitute populations of well‑characterized, readily obtainable multipotent cells with special immunomodulatory, migratory and paracrine properties rendering them appealing potential therapeutics in experimental animal models of various diseases...
January 3, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29285160/major-pathogen-microorganisms-except-yeasts-can-be-detected-from-blood-cultures-within-the-first-three-days-of-incubation-a-two-year-study-from-a-university-hospital
#6
Emmanuel Moustos, Dimitra Staphylaki, Athanasia Christidou, Demetrios A Spandidos, Ioannis K Neonakis
The knowledge of the expected time-to-positivity (TTP) of blood cultures by major pathogens is essential both clinically and economically. To this end, we conducted the present two-year study in our Institution, aiming to assess the TTP of all the major microorganisms including Enterobacteriaceae, Pseudomonas aeruginosa, Acinetoacter baumannii, Enterococcii spp, Staphylococcus aureus and yeasts, to determine whether a 3-day interval is sufficient for their detection. The TTP for each case of strain isolation per patient was determined as the TTP of the first bottle among a set of bottles collected within the same period of time to be flagged as positive per patient...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29207138/anticancer-pyridines-induce-g2-m-arrest-and-apoptosis-via-p53-and-jnk-upregulation-in-liver-and-breast-cancer-cells
#7
Vasilis P Androutsopoulos, Demetrios A Spandidos
In the present study, the synthesis and biological evaluation of one novel pyridine and one novel pyridone anticancer compound is reported. The compounds 6‑(2,4‑dimethoxyphenyl)‑4‑(3,4‑methylenedioxyphenyl)‑1H‑pyridin‑2‑one (1) and 2‑(2,4‑dimethoxyphenyl)‑4‑(3,4‑methylenedioxyphenyl)pyridine (2) were synthesized from a chalchone precursor. 1 was more active than 2 in inhibiting the proliferation of MCF‑7 and HepG2 cells, whereas HepG2 cells were more sensitive to the antiproliferative activity of these compounds compared with MCF‑7 cells...
November 28, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29207125/the-spectrum-of-myocardial-homeostasis-mechanisms-in-the-settings-of-cardiac-surgery-procedures-review
#8
Emmanuel Papadakis, Meletios Kanakis, Agapi Kataki, Demetrios A Spandidos
Classic cardiac surgery, determined through the function of cardiopulmonary bypass machine and myocardial cardioplegic arrest, represents the most controlled scenario for cardiomyocyte homeostatic disturbances due to systemic inflammatory response and myocardial reperfusion injury. An increasing number of studies have demonstrated that myocardial cell homeostasis in cardiac surgery procedures is a sequence of molecularly interrelated and overlapping mechanisms in the form of apoptosis, autophagy and necrosis, which are activated by a plethora of induced inflammatory mediators and gene‑related signaling pathways...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29097115/cytochrome-p450-cyp1-metabolism-of-hydroxylated-flavones-and-flavonols-selective-bioactivation-of-luteolin-in-breast-cancer-cells
#9
Nicola E Wilsher, Randolph R Arroo, Minos-Timotheos Matsoukas, Aristidis M Tsatsakis, Demetrios A Spandidos, Vasilis P Androutsopoulos
Natural flavonoids with methoxy substitutions are metabolized by CYP1 enzymes to yield the corresponding demethylated products. The present study aimed to characterize the metabolism and further antiproliferative activity of the hydroxylated flavonoids apigenin, luteolin, scutellarein, kaempferol and quercetin in CYP1 recombinant enzymes and in the CYP1 expressing cell lines MCF7 and MDA-MB-468, respectively. Apigenin was converted to luteolin and scutellarein, whereas kaempferol was metabolized only to quercetin by recombinant CYP1 enzymes...
October 31, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29042918/george-n-papanicolaou-1883-1962-an-exceptional-human-scientist-and-academic-teacher-an-interview-with-dr-neda-voutsa-perdiki
#10
Ioannis N Mammas, Demetrios A Spandidos
Dr Neda Voutsa-Perdiki, former Director of Exfoliative Cytology at the University of Florida (Florida, USA), talks about her academic teacher Dr George N. Papanicοlaou, referred to as the 'Father of Exfoliative Cytology', and his wife Mache, known as Mary Papanicolaou. According to Dr Voutsa-Perdiki, Dr Papanicolaou was an exceptional teacher and a unique humanitarian in modern medical history. The secret of his scientific success was hard work, dedication, love of research, faith and the courage he gained from his wife and colleagues...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042917/viral-infections-neonatal-mortality-and-the-mystery-of-the-athenian-agora-an-interview-with-professor-of-anthropology-maria-liston
#11
Ioannis N Mammas, Demetrios A Spandidos
Although excavated almost 80 years ago, the infants' 'bone well' of the Athenian Agora in Athens, Greece and its contents were never thoroughly evaluated and published, until only recently, when a re-analysis of the whole excavation findings was performed. The well dates back to the third quarter of the 2nd century BC and contained at least 449 infants. The project, which explored the causes of neonatal mortality, found that one-third of infants' deaths were attributed to neonatal meningitis, based on the presence of bone disposition on the endocranial surface of the studied skulls...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042916/the-proposal-of-paediatric-virology-and-its-perspectives-an-interview-with-professor-of-paediatrics-maria-theodoridou
#12
Ioannis N Mammas, Demetrios A Spandidos
Professor Maria Theodoridou, Emeritus Professor of Paediatrics at the University of Athens, is one of the few paediatricians in Greece, who have experienced almost all the infectious diseases of the second half of the 20th century and their severe consequences, prior to the widespread adoption of immunisations. A milestone during her career was the establishment of a specialised National Reference Unit for the care of paediatric patients with acquired immune deficiency syndrome (AIDS) at the 'Aghia Sophia' Children's Hospital in Athens, Greece...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042915/the-innovation-of-the-subspecialty-of-paediatric-virology-an-interview-with-research-professor-of-molecular-virology-anna-kramvis
#13
Ioannis N Mammas, Demetrios A Spandidos
Professor Anna Kramvis, Research Professor of Molecular Virology at the University of the Witwatersrand in Johannesburg, South Africa, talks about direct-acting antiviral treatments against hepatitis C virus (HCV), as well as the perspective of the development of an effective vaccine against HCV. She emphasises the necessity of vaccination against hepatitis B virus (HBV), highlighting that it is very important that vaccination should be administered at birth in order to prevent mother-to-child transmission (MTCT) of HBV...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042914/the-educational-challenge-of-paediatric-virology-an-interview-with-professor-of-neonatology-anne-greenough
#14
Ioannis N Mammas, Demetrios A Spandidos
According to Professor Anne Greenough, Professor of Neonatology and Clinical Respiratory Physiology at the King's College London (London, UK), Paediatric Virology is indeed a rapidly increasing educational challenge. Professor Greenough, who in 1992 wrote her book on congenital, perinatal and neonatal infections, believes that during the past 3 decades, paediatric health professionals are becoming increasingly involved in specialised care and follow-up of paediatric patients with viral diseases, who require advanced medical care and innovative technological services...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042913/paediatric-virology-as-a-new-educational-initiative-an-interview-with-nobelist-professor-of-virology-harald-zur-hausen
#15
Ioannis N Mammas, Demetrios A Spandidos
Born in Gelsenkirchen-Buer in Germany on March 11th, 1936, Professor Harald zur Hausen, Emeritus Professor of Virology at the University of Freiburg and 2008 Nobel Prize Laureate in Physiology or Medicine for his discovery of human papillomavirus (HPV), which causes cervical cancer, believes that good knowledge of virological methods and diagnostic possibilities are an asset for all young paediatricians. Professor zur Hausen considers that the creation of an educational platform on Paediatric Virology is definitely very beneficial for young paediatricians, as this will greatly enhance their knowledge in the field of Virology...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042912/hpv-vaccination-in-boys-determining-the-clinical-relevance-of-this-strategy
#16
EDITORIAL
Harald Zur Hausen, Ioannis N Mammas, Demetrios A Spandidos
No abstract text is available yet for this article.
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29039613/staphylococcus-aureus-colonisation-in-patients-from-a-primary-regional-hospital
#17
Anca Ungureanu, Ovidiu Zlatian, George Mitroi, Andrei Drocaş, Tiberiu Ţîrcă, Daniela Călina, Cristina Dehelean, Anca Oana Docea, Boris N Izotov, Valerii N Rakitskii, Ramona Cioboată, Demetrios A Spandidos, Aristides M Tsatsakis, Alice Găman
Staphylococcus aureus (SA or S. aureus) is a common pathogen that leads to local and systemic infections in communitarian and hospitalised patients. Staphylococcus colonizing nasal or pharyngeal sites can become virulent and cause severe infections. In this study, we collected 322 pharyngeal exudates and 142 nasal exudates from hospitalised and outpatients for screening purposes. The carriage rates in the pharynx were 27.06% for S. aureus, 11.55% for methicillin‑resistant S. aureus (MRSA) and 5.61% for methicillin‑oxacillin resistant S...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039546/antiproliferative-effects-of-tsa-pxd%C3%A2-101-and-ms%C3%A2-275-in-a2780-and-mcf7-cells-acetylated-histone-h4-and-acetylated-tubulin-as-markers-for-hdaci-potency-and-selectivity
#18
Vasilis P Androutsopoulos, Demetrios A Spandidos
Inhibition of histone deacetylase enzymes (HDACs) has been well documented as an attractive target for the development of chemotherapeutic drugs. The present study investigated the effects of two prototype hydroxamic acid HDAC inhibitors, namely Trichostatin A (TSA) and Belinostat (PXD‑101) and the benzamide Entinostat (MS‑275) in A2780 ovarian carcinoma and MCF7 breast adenocarcinoma cells. The three HDACi inhibited the proliferation of A2780 and MCF7 cells at comparable levels, below the µM range. Enzyme inhibition assays in a cell‑free system showed that TSA was the most potent inhibitor of total HDAC enzyme activity followed by PXD‑101 and MS‑275...
October 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039461/effects-of-ursolic-and-oleanolic-on-sk%C3%A2-mel%C3%A2-2-melanoma-cells-in%C3%A2-vitro-and-in%C3%A2-vivo-assays
#19
Angela Caunii, Camelia Oprean, Mirabela Cristea, Alexandra Ivan, Corina Danciu, Calin Tatu, Virgil Paunescu, Daniela Marti, George Tzanakakis, Demetrios A Spandidos, Aristides Tsatsakis, Razvan Susan, Codruta Soica, Stefana Avram, Cristina Dehelean
Among the triterpenoids, oleanolic acid (OA) and its isomer, ursolic acid (UA) are promising therapeutic candidates, with potential benefits in the management of melanoma. In this study, we aimed to examine the in vitro and in vivo anti‑invasive and anti‑metastatic activity of OA and UA to determine their possible usefulness as chemopreventive or chemotherapeutic agents in melanoma. For the in vitro experiments, the anti‑proliferative activity of the triterpenic compounds on SK‑MEL‑2 melanoma cells was examined...
December 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29029543/the-mir-200-family-in-ovarian-cancer
#20
REVIEW
Maria Koutsaki, Massimo Libra, Demetrios A Spandidos, Apostolos Zaravinos
Ovarian cancer (OC) is the most lethal gynecological malignancy. Its insidious nature, manifesting with little to no symptoms until the disease progresses to metastasis, along with a wide diversity of histological subtypes and corresponding clinical behavior, poses significant therapeutic challenges. The genetic profiling of this aggressive tumor and its subtypes has led to the identification of various molecular markers of prognosis. Among these, the miR-200 family of miRNAs appears to play an important role...
September 12, 2017: Oncotarget
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