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Asafoetida

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https://www.readbyqxmd.com/read/27540324/possible-mechanisms-for-functional-antagonistic-effect-of-ferula-assafoetida-on-muscarinic-receptors-in-tracheal-smooth-muscle
#1
Majid Kiyanmehr, Mohammad Hossein Boskabady, Mohammad Reza Khazdair, Milad Hashemzehi
BACKGROUND: The contribution of histamine (H1) receptors inhibitory and/or β-adrenoceptors stimulatory mechanisms in the relaxant property of Ferula assa-foetida. (F. asafoetida) was examined in the present study. METHODS: We evaluated the effect of three concentrations of F. asafoetida extract (2.5, 5, and 10 mg/mL), a muscarinic receptors antagonist, and saline on methacholine concentration-response curve in tracheal smooth muscles incubated with β-adrenergic and histamine (H1) (group 1), and only β-adrenergic (group 2) receptors antagonists...
January 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27104031/nematicidal-and-antimicrobial-activities-of-methanol-extracts-of-17-plants-of-importance-in-ethnopharmacology-obtained-from-the-arabian-peninsula
#2
Adel Al-Marby, Chukwunonso Ecc Ejike, Muhammad Jawad Nasim, Nasser A Awadh-Ali, Rwaida A Al-Badani, Ghanem Ma Alghamdi, Claus Jacob
AIM/BACKGROUND: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. MATERIALS AND METHODS: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays...
March 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/26963574/sulphur-containing-compounds-in-the-essential-oil-of-ferula-alliacea-roots-and-their-mass-spectral-fragmentation-patterns
#3
Jamal Kasaian, Javad Asili, Mehrdad Iranshahi
Context GC-MS analysis is the best way to characterize volatile sulphur-containing compounds. Ferula (Apiaceae) is a genus of perennial herbs. Due to the occurrence of essential oils or oleoresins in the Ferula species, these plants usually possess strong aromatic scent. Terpenoid compounds were the most abundant constituents of Ferula oils, however, in some of Ferula species, the essential oils were dominated by volatile sulphur-containing compounds. Objectives Ferula alliacea Boiss. is considered one of the sources of the oleo-gum-resin asafoetida...
October 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/26604552/effect-of-ferula-assa-foetida-oleo-gum-resin-on-spermatic-parameters-and-testicular-histopathology-in-male-wistar-rats
#4
Seyyed Majid Bagheri, Maryam Yadegari, Majid Porentezari, Aghdas Mirjalili, Ashraf Hasanpor, R Mohammad Hossein Dashti, Morteza Anvari
BACKGROUND: In Ayurveda and traditional medicines of different countries such as Iran, America and Brazil, asafoetida has been used as an aphrodisiac agent. OBJECTIVE: The present study was aimed to evaluate the effectiveness of asafoetida on spermatic and testicular parameters in treated rats. MATERIALS AND METHODS: A total of 30 male Wistar rats divided equally to five groups (one control and four test groups receiving 25, 50,100 and 200 mg/kg asafoetida respectively)...
July 2015: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/25985573/potential-inhibitory-effect-of-herbal-medicines-on-rat-hepatic-cytochrome-p450-2d-gene-expression-and-metabolic-activity
#5
F I Al-Jenoobi, H M Korashy, A Ahad, M Raish, A M Al-Mohizea, M A Alam, S A Al-Suwayeh, K M Alkharfy
The aim of current study was to investigate the effect of some commonly used medicinal herbs on the regulation of rat CYP2D gene expression and its metabolic activity. Wistar albino rats were treated for seven consecutive days with selected doses of five commonly used herbs (Trigonella foenum-graecum, Ferula asafoetida, Nigella sativa, Commiphora myrrha and Lepidium sativum). Thereafter, rat livers were harvested and CYP2D mRNA levels were determined by RT-PCR. The metabolic activity of CYP2D was performed on rat hepatic microsomes using dextromethorphan as specific substrate...
November 2014: Die Pharmazie
https://www.readbyqxmd.com/read/25788433/influence-of-asafoetida-on-prevention-and-treatment-of-memory-impairment-induced-by-d-galactose-and-nano2-in-mice
#6
Seyyed Majid Bagheri, Mohammad Hossein Dashti-R
In Iranian traditional medicine, asafoetida is introduced as a valuable remedy for nervous disorders. Dementia was induced by injection of d-galactose and NaNO2 for 60 consecutive days. Animals were divided into normal control (NC), dementia control (DC), dementia prophylactic (DP), and dementia treated (DT). The learning and memory functions were examined by 1-way active and passive avoidance tests, using a shuttle box device. Avoidance response in training tests and 1 and 3 weeks later was significantly increased in NC, DP, and DT groups compared to the DC group...
September 2015: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/25657791/antinociceptive-effect-of-ferula-assa-foetida-oleo-gum-resin-in-mice
#7
S M Bagheri, M H Dashti-R, A Morshedi
Ferula assa-foetida L. is distributed throughout central Asia and Mediterranean area and grows wildly in Iran and Afghanistan. Asafoetida is an oleo-gum-resin that is the exudates of the roots of Ferula assa-foetida and some other Ferula species. In Iranian traditional medicine, asafoetida is considered to be sedative, analgesic, carminative, antispasmodic, diuretic, antihelmintic, emmenagogue and expectorant. The aim of this study was to evaluate the antinociceptive effect of asafoetida in mice. The analgesic activity of asafoetida (25, 50 and 100 mg/kg) was compared with that of sodium diclofenac (30 mg/kg) or morphine sulfate (8 mg/kg) by using hot plate and acetic acid induced writhing tests...
May 2014: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25564444/inhibition-of-quorum-sensing-in-pseudomonas-aeruginosa-by-two-herbal-essential-oils-from-apiaceae-family
#8
Ehsan Sepahi, Saeed Tarighi, Farajollah Shahriari Ahmadi, Abdolreza Bagheri
Ferula (Ferula asafoetida L.) and Dorema (Dorema aucheri Bioss.) both from Apiaceae family were tested for their anti-quorum sensing (QS) activity against Pseudomonas aeruginosa. Both essential oils exhibited anti-QS activity at 25 μg/ml of concenteration. At this concenteration Ferula fully abolished and Dorema reduced the violacein production by C. violaceum. Pyocyanin, pyoverdine, elastase and biofilm production were decreased in Ferula oil treatments. Dorema oil reduced pyoverdine and elastase production, while pyocyanin and biofilm production were not affacted...
February 2015: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/25210675/anticonvulsant-effect-of-ferula-assa-foetida-oleo-gum-resin-on-chemical-and-amygdala-kindled-rats
#9
Seyyed Majid Bagheri, Mohamad Ebrahim Rezvani, Ali Reza Vahidi, Mansur Esmaili
BACKGROUND: In Iranian traditional medicine, Ferula assa-foetida oleo gum resin (asafoetida) have been used as anti-convulsant agents. AIMS: This study was designed to evaluate the anti-convulsant effect of asafoetida on chemical and amygdala -kindled rats. MATERIALS AND METHODS: In chemical model, rats received orally asafoetida at dose of 50 and 100 mg/kg 90 minutes prior to Pentylenetetrazol injection in dose of 35 mg/kg intraperitoneally (i...
August 2014: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/25099385/impact-of-herbal-medicines-like-nigella-sativa-trigonella-foenum-graecum-and-ferula-asafoetida-on-cytochrome-p450-2c11-gene-expression-in-rat-liver
#10
H M Korashy, F I Al-Jenoobi, M Raish, A Ahad, A M Al-Mohizea, M A Alam, K M Alkharfy, S A Al-Suwayeh
AIM: Combined use of herbs and drugs may result in clinically important herb-drug interactions. The majorities of these interactions are thought to be metabolism-based and involve induction or inhibition of cytochrome P450 (CYP). The current study was designed to investigate the effect of some commonly used herbs on rat CYP2C11 gene expression and metabolic activity. METHODS: Wistar rats were treated for 7 days with increasing doses of 3 herbs; Nigella sativa, Trigonella foenum-graecum, and Ferula asafoetida...
July 2015: Drug Research
https://www.readbyqxmd.com/read/24761245/the-relaxant-effect-of-seed-s-essential-oil-and-oleo-gum-resin-of-ferula-assa-foetida-on-isolated-rat-s-ileum
#11
Sm Bagheri, Sh Hejazian, Mh Dashti-R
BACKGROUND: In Iranian folk medicine, several plants are used for treatment of gastrointestinal disorders, such as diarrhea and spasm. One of these herbal medications are the essential oil yielded from seeds of Ferula assa-foetida L. and an oleo-gum-resin known as asafetida, which is exudated from its root. F. assa-foetida grows wildly in south and central mountains of Iran. AIM: In this study, relaxant effect of asafoetida and seed's essential oil of F. assa-foetida was investigated in isolated rat's ileum in three doses...
March 2014: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/24709312/oleo-gum-resin-of-ferula-assa-foetida-l-ameliorates-peripheral-neuropathy-in-mice
#12
Farshad Homayouni Moghadam, Maryam Dehghan, Ehsan Zarepur, Reyhaneh Dehlavi, Fatemeh Ghaseminia, Shima Ehsani, Golnaz Mohammadzadeh, Kazem Barzegar
ETHNOPHARMACOLOGICAL RELEVANCE: According to the Chinese, European, Iranian and Indian traditional medicines, oleo gum resin of Ferula assa-foetida (asafoetida) has therapeutic effects on different kinds of diseases. Some of these effects are related to the diseases of nervous system such as hysteresis and convulsion. In recent studies, some anti-epileptic and neuroprotective roles were also considered for it and we examined its possible role on treatment of peripheral neuropathy. MATERIAL AND METHODS: in vitro studies were carried out to identify the response of isolated sciatic nerves to different concentrations of oleo gum resin of asafoetida solved in Lock׳s solution...
May 28, 2014: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/24338082/relaxant-effects-of-asafoetida-extract-and-its-constituent-umbelliprenin-on-guinea-pig-tracheal-smooth-muscle
#13
Goltaj Bayrami, Mohammad Hossein Boskabady, Mehrdad Iranshahi, Zahra Gholamnezhad
OBJECTIVE: To investigate the relaxant effects of the asafoetida (Ferula Asafoetida Oleo-Gum-Resin) and its coumarin constituent umbelliprenin on tracheal chains of guinea pigs. METHODS: The relaxant effects of three cumulative concentrations of the aqueous extract (2, 5 and 10 mg/mL), umbelliprenin (0.04, 0.2 and 0.4 mg/mL), theophylline (0.05, 0.1 and 0.15 mg/mL) and saline were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60 mmol/L KCl (group 1), and 10 μ mol/L methacholine (group 2)...
December 12, 2013: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/24302807/a-validated-high-performance-liquid-chromatograhy-method-for-estimation-of-ferulic-acid-in-asafoetida-and-polyherbal-preparation
#14
J A Kareparamban, P H Nikam, A P Jadhav, V J Kadam
A high-performance liquid chromatography method was developed for the estimation of ferulic acid from asafoetida and a polyherbal preparation. The separation was carried out on HiQSil ODS C-18 column with a mobile phase of acetonitrile: 10% acetic acid (20:80 v/v). The developed method was validated as per International Conference of Harmonization guidelines for various parameters such as accuracy, precision, linearity, limit of detection, limit of quantification and specificity; and found to be reliable. Linear regression analysis showed a good corelation between peak area and concentration with a corelation coefficient r(2)=0...
July 2013: Indian Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/24250950/double-edged-effect-of-gum-resin-of-ferula-assa-foetida-on-lifespan-of-neurons
#15
Farshad Homayouni Moghadam, Behzad Vakili Zarch, Mohammad Shafiei
OBJECTIVE(S): Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS: In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specific markers β-Tubulin III and MAP2. After establishment of neuronal differentiation in cultured cells, aqueous extract of gum-resin of asafoetida were applied on culture medium of neurons with different concentrations then survival rate of neurons were evaluated by cell counting and methyl tetrazolium bromide (MTT) tests...
April 2013: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/24250948/double-edged-effect-of-gum-resin-of-ferula-assa-foetida-on-lifespan-of-neurons
#16
Farshad Homayouni Moghadam, Behzad Vakili Zarch, Mohammad Shafiei
OBJECTIVE(S): Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS: In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specific markers β-Tubulin III and MAP2. After establishment of neuronal differentiation in cultured cells, aqueous extract of gum-resin of asafoetida were applied on culture medium of neurons with different concentrations then survival rate of neurons were evaluated by cell counting and methyl tetrazolium bromide (MTT) tests...
April 2013: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/24222383/homeopathy-for-treatment-of-irritable-bowel-syndrome
#17
REVIEW
Emily J Peckham, E Andrea Nelson, Joanne Greenhalgh, Katy Cooper, E Rachel Roberts, Anurag Agrawal
BACKGROUND: Irritable bowel syndrome (IBS) is a common, chronic disorder that leads to decreased health-related quality of life and work productivity. Evidence-based treatment guidelines have not been able to give guidance on the effects of homeopathic treatment for IBS because no systematic reviews have been carried out to assess the effectiveness of homeopathic treatment for IBS. Two types of homeopathic treatment were evaluated in this systematic review. In clinical homeopathy a specific remedy is prescribed for a specific condition...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24199478/tertiary-combination-of-freeze-dried-urine-of-indian-breeds-of-cow-with-plant-products-against-snail-lymnaea-acuminata
#18
Shiv Kumar, D K Singh, Vinay Kumar Singh
Snail Lymnaea acuminata is the intermediate host of liver fluke Fasciola gigantica, which cause endemic fasciolosis among cattle population of eastern Uttar Pradesh. Control of snail population by molluscicides is one of the effective methods to control fasciolosis. In the present study molluscicidal activity of tertiary combination of freeze-dried urine of different Indian breeds of cow Sahiwal, Geer and Tharparkar with Annona squamosa seed powder, Ferula asafoetida root latex, Azadirachta indica oil and Camellia sinensis leaves have been tested against Lymnaea acuminata...
October 15, 2012: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/24050586/use-of-complementary-and-alternative-medicine-for-children-a-parents-perspective
#19
Ashry Gad, Eiad Al-Faris, Noura Al-Rowais, Mohamed Al-Rukban
OBJECTIVES: The present study aims to detect the frequency and types of complementary and alternative medicine (CAM) therapies used for children and to explore parental motivating factors for using CAM for their children in Riyadh, Saudi Arabia. PARTICIPANTS AND METHODS: This is a cross-sectional study that involved 462 families selected through a multistage cluster-sampling technique covering Riyadh region, Saudi Arabia. The sample was selected from 40 clusters, distributed proportionally according to the size of the population in the catchment area of primary health care centres (PHCCs)...
October 2013: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/23954176/some-like-it-pungent-and-vile-trpa1-as-a-molecular-target-for-the-malodorous-vinyl-disulfides-from-asafoetida
#20
Yalda Shokoohinia, Giuseppina Chianese, Giovanni Appendino, Vincenzo Di Marzo, Luciano De Petrocellis, Alireza Ghannadi, Roshanak Taghvayi, Khadijeh Fattahian, Reza Soltani, Orazio Taglialatela-Scafati
Ferula assa-foetida L. is a major source of asafoetida, a foul-smelling gum-resin of dietary and medicinal relevance. Investigation of the roots and latex of F. assa-foetida yielded various mixed vinyl disulfides, including two novel asadisulfide-type esters. The reactivity of asadisulfide was investigated in the cysteamine NMR assay, where it behaved as disulfide shuffling agents due to the high mobility of the vinyl sulfide moiety. In accordance with their transthiolation capacity, these compounds potently activated TRPA1, the target of mustard oil and the pungent sulfur compounds from onion and garlic, qualifying S-alkyl-S-alkenyldisulfides, a rare class of natural products, as a novel class of dietary TRPA1 activators...
October 2013: Fitoterapia
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