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https://www.readbyqxmd.com/read/29751723/-study-on-medication-laws-of-tibetan-medicine-in-treatment-of-plateau-disease-based-on-data-mining-technology
#1
Huan Liu, Cai-Yun Zhao, Wen Zhang, Yi Zhang, Jia Nie
Traditional Chinese medicine inheritance support system (TCMISS, V2.5) was used in this study to analyze the common medicines, frequency of medicine combination, core herbal combinations and new prescriptions for the treatment of plateau disease from the Four-Volume Medical Code, Mannose Herbal Mirror and other related books. TCMISS V2.5 software was used to construct the database of drug treatment for plateau disease. The frequency analysis and association rules apriori algorithm, improved mutual information method and other data mining methods were used to explore the law of drug compatibility...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29717575/the-in-vitro-effect-of-ferula-asafoetida-and-allium-sativum-extracts-on-strongylus-spp
#2
Mousa Tavassoli, Ghader Jalilzadeh-Amin, Vahid R. Besharati Fard, Rahim Esfandiarpour
The high incidence of equine gastrointestinal worms and their increased resistance against anthelmintics has encouraged research into the effectiveness of rational phytotherapy. This study investigates the in vitro anti-parasitic effects of extracts of Ferula asafoetida and Allium sativum, two native plants that are widespread in Iran on Strongylus spp. larvae. Faecal samples were collected from horses, examined by routine parasitology methods and positive samples were used for future examination. After incubation, the third-stage larvae were harvested by the Baermann technique...
2018: Annals of Parasitology
https://www.readbyqxmd.com/read/29701161/ferula-gummosa-boiss-inhibits-multi-drug-resistant-clinical-pseudomonas-aeruginosas
#3
Fereshteh Satarian, Hamideh Mahmoodzadeh Hosseini, Abdolamir Ghadaksaz, Mohsen Amin, Abbas Ali Imani Fooladi
BACKGROUND: Multi-drug resistance among Pseudomonas aeruginosa (P. aeruginosa) clinical isolates is increasing and becoming a serious problem for public health authorities worldwide. OBJECTIVE: The aim of current study is the introducing a potent antibacterial compound against the resistant P. aeruginosa. The recent patents on antimicrobial properties of extracts drived from Apiaceae family plants (WO2017216602A1, KR20050054247A and KR100285781B1) were used to to assess other member Ferula gummosa (F...
April 26, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29627637/determination-and-pharmacokinetic-study-of-guaiol-in-rat-plasma-by-gas-chromatography-mass-spectrometry-with-selected-ion-monitoring
#4
Minghan Yang, Jiaoyang Luo, Kunlun Li, Shurong Hu, Tong Ding, Hao Liu, Ping Sheng, Meihua Yang
Guaiol has been used for thousands of years as a traditional Uygur medicine and is the primary active component found in Ferula ferulaeoides (Steud.) Korov (F. ferulaeoides). In our present study, a rapid, selective, and sensitive method of monitoring selected ions was established based on gas chromatography-mass spectrometry. This method was optimized for the quantification and pharmacokinetic analysis of guaiol in rat plasma following oral administration of chloroform extract from Ferula ferulaeoides. Plasma was extracted using liquid-liquid extraction with ethyl acetate and was analyzed on a HP-5MS column (30 m × 250 μm × 0...
May 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29594529/ferutinin-induces-membrane-depolarization-permeability-transition-pore-formation-and-respiration-uncoupling-in-isolated-rat-liver-mitochondria-by-stimulation-of-ca-2-permeability
#5
Tatsiana Ilyich, Oksana Charishnikova, Szymon Sekowski, Maria Zamaraeva, Vitali Cheshchevik, Iosif Dremza, Nina Cheshchevik, Lyudmila Kiryukhina, Elena Lapshina, Ilya Zavodnik
It is well known that the terpenoid ferutinin (4-oxy-6-(4-oxybenzoyloxy) dauc-8,9-en), isolated from the plant Ferula tenuisecta, considerably increases the permeability of artificial and cellular membranes to Ca2+ -ions and produces apoptotic cell death in different cell lines in a mitochondria-dependent manner. The present study was designed for further evaluation of the mechanism(s) of mitochondrial effects of ferutinin using isolated rat liver mitochondria. Our findings provide evidence for ferutinin at concentrations of 5-27 µM to decrease state 3 respiration and the acceptor control ratio in the case of glutamate/malate as substrates...
March 28, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29593299/bacterial-diversity-and-community-structure-in-the-rhizosphere-of-four-ferula-species
#6
Xiuling Wang, Zhongke Wang, Ping Jiang, Yaling He, Yudi Mu, Xinhua Lv, Li Zhuang
The medicinal value of the Ferula L. has been recognized for more than a thousand years. Wild stocks of Ferula have declined dramatically because high economic value has led to overharvesting. The objective of this study was to compare the rhizosphere microbial community of four Ferula species [F. syreitschikowii K.-Pol., F. gracilis (Ledeb.) Ledeb., F. ferulaeoides (Steud.) Korov., and F. lehmannii Boiss.] in the northern part of Xinjiang, China. The 16S rRNA sequences of rhizosphere bacteria were obtained with an Illumina paired-end sequence platform...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29587544/ferula-pseudalliacea-induces-apoptosis-in-human-colorectal-cancer-hct-116-cells-via-mitochondria-dependent-pathway
#7
Hadi Bamehr, Massoud Saidijam, Dara Dastan, Razieh Amini, Mona Pourjafar, Rezvan Najafi
Ferula species have diverse biological functions. This study set out to investigate the anti-proliferative effects of methanolic extract of F. pseudalliacea against human colon cancer HCT-116 cell line. Cytotoxic effects of F. pseudalliacea on HCT-116 cells was estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. Real-time polymerase chain reaction (PCR) and Western blot were employed to analyze BAX and Bcl2 expression. Cell cycle analysis and apoptosis were conducted using flowcytometry and Annexin V/ propidium iodide (PI) staining...
March 27, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29576774/comparison-of-antimicrobial-effect-of-ziziphora-tenuior-dracocephalum-moldavica-ferula-gummosa-and-prangos-ferulacea-essential-oil-with-chlorhexidine-on-enterococcus-faecalis-an-in-vitro-study
#8
Bahareh Nazemisalman, Surena Vahabi, Ali Yazdinejad, Fatemeh Haghghi, Mahsa Shabbuii Jam, Fatemeh Heydari
Background: Different irrigating solutions with high antimicrobial activity have been introduced for cleaning of the root canal system. However, effects of Prangos ferulacea (PF), Ziziphora tenuior (ZT), Dracocephalum moldavica (DM), and Ferula gummosa (FG) on oral and dental pathogens have not been extensively evaluated due to their optimal biocompatibility and insignificant side effects. The aim of this study was to evaluate the antibacterial effects of essential oils of mentioned plants on Enterococcus faecalis ...
March 2018: Dental Research Journal
https://www.readbyqxmd.com/read/29484829/taste-sensitivity-and-divergence-in-host-plant-acceptance-between-adult-females-and-larvae-of-papilio-hospiton
#9
Giorgia Sollai, Maurizio Biolchini, Roberto Crnjar
On the island of Sardinia the lepidopteran Papilio hospiton uses Ferula communis as exclusive host plant. However, on the small island of Tavolara, adult females lay eggs on Seseli tortuosum, a plant confined to the island. When raised in captivity on Seseli only few larvae grew beyond the first-second instar. Host specificity of lepidopterans is determined by female oviposition preferences, but also by larval food acceptance, and adult and larval taste sensitivity may be related to host selection in both cases...
February 27, 2018: Insect Science
https://www.readbyqxmd.com/read/29454611/taste-receptor-plasticity-in-relation-to-feeding-history-in-two-congeneric-species-of-papilionidae-lepidoptera
#10
Giorgia Sollai, Maurizio Biolchini, Roberto Crnjar
In the peripheral taste system of insects, the responsiveness of gustatory receptor neurons (GRNs) depends on several factors, such as larval instar, feeding history, physiological state and time of day. To study the role of the feeding history, the spike activity of the maxillary taste chemosensilla in the larvae of two related species of Lepidoptera (Papilio machaon L. and Papilio hospiton Géné) raised on different host plants, was recorded with electrophysiological techniques after stimulation with simple stimuli (sugars, bitters and inorganic salt) and host plant saps, with the aim of cross-comparing their response patterns and evaluating any effects of different feeding histories...
February 15, 2018: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29378434/tlc-bioautography-directed-isolation-of-antibacterial-compounds-from-active-fractionation-of-ferula-ferulioides
#11
Zhong-Lin Sun, Tao Liu, Shuang-Ying Wang, Xiao-Yue Ji, Qing Mu
A novel optimised isolation method, TLC-bioautography, was evaluated and utilised in this research. Antibacterial compounds which were isolated from the dichloromethane extract of Ferula ferulioides (Steud.) Korovin were detected by means of the method. Their structures were elucidated by extensive spectral and chemical methods. Their antibacterial activities against drug-resistant Staphylococcus aureus (S. aureus) strains were evaluated with broth microdilution method, and the results proved that TLC-bioautography was an effective and highly efficient way to screen natural compounds from plant extracts against drug-resistant strains...
January 30, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29273556/mining-ferula-gummosa-transcriptome-to-identify-mirnas-involved-in-the-regulation-and-biosynthesis-of-terpenes
#12
Ahmad Sobhani Najafabadi, Mohammad Reza Naghavi
Ferula gummosa is a well-known medicinal and industrial plant for its oleo-gum-resin named galbanum. So far, there is no information about the role of miRNAs on the production of terpenes as the major secondary metabolite of galbanum. In the present study, RNA-seq data on the root and flower of the plant were used to predict miRNAs and their targets using computational approaches. Additionally, biological network analyses were used to unravel the direct or indirect regulatory effects of miRNAs on the targets involved in terpene biosynthesis...
March 1, 2018: Gene
https://www.readbyqxmd.com/read/29245482/new-taxa-and-new-records-of-butterflies-lepidoptera-pieridae-lycaenidae-nymphalidae-from-afghanistan
#13
Vadim Tshikolovets
Three new species Karanasa naumanni sp. nov., K. pardesi sp. nov. and K. pseudopamira sp. nov. (Nymphalidae), two new subspecies Karanasa pamira biocellata subsp. nov. (Nymphalidae) and Plebejus (Afarsia) sieversii albolunulatus subsp. nov. (Lycaenidae) are described from Afghanistan. First occurrence records for this country are presented for 26 species: one species of Pieridae (Colias thisoa), fifteen species of Lycaenidae (Deudoryx epijarbas, Everes dipora, Glaucopsyche charybdis, Hyrcanana evansii, Iolana gigantea, Lycaena kasyapa, Plebejus ferganus, Polyommatus amandus, P...
November 28, 2017: Zootaxa
https://www.readbyqxmd.com/read/29208170/ferula-gummosa-gum-induces-apoptosis-via-ros-mechanism-in-human-leukemic-cells
#14
Maliheh Moradzadeh, Hamid Reza Sadeghnia, Seyed Hadi Mousavi, Merat Mahmoodi, Azar Hosseini
Ferula species known for its oleo-resins that are recognized valuable industrial crops and food products. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by oleo resin gum from Ferula gummosa (30-250 µg/mL), as well as Arsenic trioxide (50 µM, as positive control), in leukemic (NB4 and HL-60 cells) and normal polymorph nuclear cells during 72 h. Resazurin assay was used to determine cell viability following treatment with F. gummosa (30-250 µg/mL)...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29201097/the-evaluation-and-comparing-of-cytotoxic-effects-of-ferula-gummosa-gum-scutellaria-lindbergii-kelussia-odoratissima-and-artemisia-kopetdaghensis-extracts-on-achn-cell-line
#15
Azar Hosseini, Elham Bakhtiari, Abolfazl Khajavi Rad, Samira Shahraki, Seyed Hadi Mousavi, Shahrzad Havakhah, Mohammad Sadegh Amiri
Renal cell carcinoma (RCC) is one of most fatal cancers. In most patients it is resistant to chemotherapy. Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima, and Artemisia kopetdaghensis are herbs about which there are some cytotoxic activity reports. In this study, cytotoxic and apoptotic activity of these four extracts on RCC cell line (ACHN) were evaluated and compared (ACHN) cells were treated with different concentrations of herbal extracts (15-500 μg/mL). Cell proliferation was determined after 24, 48, and 72 h...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29157833/vasodilatory-effect-of-asafoetida-essential-oil-on-rat-aorta-rings-the-role-of-nitric-oxide-prostacyclin-and-calcium-channels
#16
Hassan Esmaeili, Mozhdeh Sharifi, Mansour Esmailidehaj, Mohammad Ebrahim Rezvani, Zeynab Hafizibarjin
BACKGROUND: Asafoetida is an oleo-gum resin mainly obtained from Ferula assa-foetida L. species in the apiaceae family. Previous studies have shown that it has antispasmodic effects on rat's and pig's ileums. PURPOSE: The main goals of this study were to assess the vasodilatory effect of asafoetida essential oil (AEO) on the contractile response of rat's aorta rings and to find the role of nitric oxide, cyclooxygenase, and calcium channels. Thoracic aorta rings were stretched under a steady-state tension of 1 g in an organ bath apparatus for 1 h and then precontracted by KCl (80 mM) in the presence and absence of AEO...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29149037/development-of-novel-polymorphic-est-ssr-markers-in-bailinggu-pleurotus-tuoliensis-for-crossbreeding
#17
Yueting Dai, Wenying Su, Chentao Yang, Bing Song, Yu Li, Yongping Fu
Identification of monokaryons and their mating types and discrimination of hybrid offspring are key steps for the crossbreeding of Pleurotus tuoliensis (Bailinggu). However, conventional crossbreeding methods are troublesome and time consuming. Using RNA-seq technology, we developed new expressed sequence tag-simple sequence repeat (EST-SSR) markers for Bailinggu to easily and rapidly identify monokaryons and their mating types, genetic diversity and hybrid offspring. We identified 1110 potential EST-based SSR loci from a newly-sequenced Bailinggu transcriptome and then randomly selected 100 EST-SSRs for further validation...
November 17, 2017: Genes
https://www.readbyqxmd.com/read/29142397/chemical-composition-antimicrobial-and-antitumor-potentiality-of-essential-oil-of-ferula-tingitana-l-apiaceae-grow-in-libya
#18
Waleed Elghwaji, Abeer Mohamed El-Sayed, Kadriya S El-Deeb, Aly M ElSayed
Background: Ferula tingitana L. (Apiaceae) has been considered to have abortive and menstruation-inducing properties. It used to treat sore throat, fever, indigestion, and pains. Objectives: The objective of this study is to establish the chemical composition of the essential oil of flower, leaves of F. tingitana , and to throw light on antimicrobial, cytotoxic activities of Libyan plant. Materials and Methods: The chemical composition of the essential oil of flower (0...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29066298/sulfur-containing-compounds-from-the-roots-of-ferula-latisecta-and-their-cytotoxic-activities
#19
Saba Soltani, Gholam-Reza Amin, Mohammad Hossein Salehi-Sourmaghi, Bernd Schneider, Sybille Lorenz, Mehrdad Iranshahi
Five new sulfur-containing compounds, with a new geometry (cis) of the propenyl moiety, and five known compounds were isolated from the roots of Ferula latisecta. The structures of these compounds, were elucidated on the basis of spectroscopic data including 1D and 2D NMR experiments and HRMS. All of the isolated compounds were tested against A2780, A549, HeLa, and HCT116 human cancer cell lines and some of them showed moderate cytotoxic activities.
January 2018: Fitoterapia
https://www.readbyqxmd.com/read/29062804/effect-of-the-methanolic-extracts-of-different-parts-of-ferula-assa-foetida-on-naloxone-induced-withdrawal-behavior-in-morphine-dependent-mice
#20
Mahnaz Khanavi, Sajad Maadani, Behnaz Farahanikia, Mahdieh Eftekhari, Mohammad Sharifzadeh
OBJECTIVE: Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetida on withdrawal syndrome in morphine-dependent mice. MATERIALS AND METHODS: Aerial parts, roots, and fruits of the plant were separately extracted with 80% MeOH. For induction of dependence, morphine (50, 50 and 75 mg/kg) was injected subcutaneously three times daily (10 am, 1 pm and 4 pm) for three days and a last dose of morphine (50 mg/kg) was administrated on the fourth day...
September 2017: Avicenna Journal of Phytomedicine
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