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https://www.readbyqxmd.com/read/29273556/mining-ferula-gummosa-transcriptome-to-identify-mirnas-involved-in-the-regulation-and-biosynthesis-of-terpenes
#1
Ahmad Sobhani Najafabadi, Mohammad Reza Naghavi
Ferula gummosa is a well-known medicinal and industrial plant for its oleo-gum-resin named galbanum. So far, there is no information about the role of miRNAs on the production of terpenes as the major secondary metabolite of galbanum. In the present study, RNA-seq data on the root and flower of the plant were used to predict miRNAs and their targets using computational approaches. Additionally, biological network analyses were used to unravel the direct or indirect regulatory effects of miRNAs on the targets involved in terpene biosynthesis...
December 19, 2017: Gene
https://www.readbyqxmd.com/read/29245482/new-taxa-and-new-records-of-butterflies-lepidoptera-pieridae-lycaenidae-nymphalidae-from-afghanistan
#2
Vadim Tshikolovets
Three new species Karanasa naumanni sp. nov., K. pardesi sp. nov. and K. pseudopamira sp. nov. (Nymphalidae), two new subspecies Karanasa pamira biocellata subsp. nov. (Nymphalidae) and Plebejus (Afarsia) sieversii albolunulatus subsp. nov. (Lycaenidae) are described from Afghanistan. First occurrence records for this country are presented for 26 species: one species of Pieridae (Colias thisoa), fifteen species of Lycaenidae (Deudoryx epijarbas, Everes dipora, Glaucopsyche charybdis, Hyrcanana evansii, Iolana gigantea, Lycaena kasyapa, Plebejus ferganus, Polyommatus amandus, P...
November 28, 2017: Zootaxa
https://www.readbyqxmd.com/read/29208170/ferula-gummosa-gum-induces-apoptosis-via-ros-mechanism-in-human-leukemic-cells
#3
Maliheh Moradzadeh, Hamid Reza Sadeghnia, Seyed Hadi Mousavi, Merat Mahmoodi, Azar Hosseini
Ferula species known for its oleo-resins that are recognized valuable industrial crops and food products. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by oleo resin gum from Ferula gummosa (30-250 µg/mL), as well as Arsenic trioxide (50 µM, as positive control), in leukemic (NB4 and HL-60 cells) and normal polymorph nuclear cells during 72 h. Resazurin assay was used to determine cell viability following treatment with F. gummosa (30-250 µg/mL)...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29201097/the-evaluation-and-comparing-of-cytotoxic-effects-of-ferula-gummosa-gum-scutellaria-lindbergii-kelussia-odoratissima-and-artemisia-kopetdaghensis-extracts-on-achn-cell-line
#4
Azar Hosseini, Elham Bakhtiari, Abolfazl Khajavi Rad, Samira Shahraki, Seyed Hadi Mousavi, Shahrzad Havakhah, Mohammad Sadegh Amiri
Renal cell carcinoma (RCC) is one of most fatal cancers. In most patients it is resistant to chemotherapy. Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima, and Artemisia kopetdaghensis are herbs about which there are some cytotoxic activity reports. In this study, cytotoxic and apoptotic activity of these four extracts on RCC cell line (ACHN) were evaluated and compared (ACHN) cells were treated with different concentrations of herbal extracts (15-500 μg/mL). Cell proliferation was determined after 24, 48, and 72 h...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29157833/vasodilatory-effect-of-asafoetida-essential-oil-on-rat-aorta-rings-the-role-of-nitric-oxide-prostacyclin-and-calcium-channels
#5
Hassan Esmaeili, Mozhdeh Sharifi, Mansour Esmailidehaj, Mohammad Ebrahim Rezvani, Zeynab Hafizibarjin
BACKGROUND: Asafoetida is an oleo-gum resin mainly obtained from Ferula assa-foetida L. species in the apiaceae family. Previous studies have shown that it has antispasmodic effects on rat's and pig's ileums. PURPOSE: The main goals of this study were to assess the vasodilatory effect of asafoetida essential oil (AEO) on the contractile response of rat's aorta rings and to find the role of nitric oxide, cyclooxygenase, and calcium channels. Thoracic aorta rings were stretched under a steady-state tension of 1 g in an organ bath apparatus for 1 h and then precontracted by KCl (80 mM) in the presence and absence of AEO...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29149037/development-of-novel-polymorphic-est-ssr-markers-in-bailinggu-pleurotus-tuoliensis-for-crossbreeding
#6
Yueting Dai, Wenying Su, Chentao Yang, Bing Song, Yu Li, Yongping Fu
Identification of monokaryons and their mating types and discrimination of hybrid offspring are key steps for the crossbreeding of Pleurotus tuoliensis (Bailinggu). However, conventional crossbreeding methods are troublesome and time consuming. Using RNA-seq technology, we developed new expressed sequence tag-simple sequence repeat (EST-SSR) markers for Bailinggu to easily and rapidly identify monokaryons and their mating types, genetic diversity and hybrid offspring. We identified 1110 potential EST-based SSR loci from a newly-sequenced Bailinggu transcriptome and then randomly selected 100 EST-SSRs for further validation...
November 17, 2017: Genes
https://www.readbyqxmd.com/read/29142397/chemical-composition-antimicrobial-and-antitumor-potentiality-of-essential-oil-of-ferula-tingitana-l-apiaceae-grow-in-libya
#7
Waleed Elghwaji, Abeer Mohamed El-Sayed, Kadriya S El-Deeb, Aly M ElSayed
Background: Ferula tingitana L. (Apiaceae) has been considered to have abortive and menstruation-inducing properties. It used to treat sore throat, fever, indigestion, and pains. Objectives: The objective of this study is to establish the chemical composition of the essential oil of flower, leaves of F. tingitana, and to throw light on antimicrobial, cytotoxic activities of Libyan plant. Materials and Methods: The chemical composition of the essential oil of flower (0...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29066298/sulfur-containing-compounds-from-the-roots-of-ferula-latisecta-and-their-cytotoxic-activities
#8
Saba Soltani, Gholam-Reza Amin, Mohammad Hossein Salehi-Sourmaghi, Bernd Schneider, Sybille Lorenz, Mehrdad Iranshahi
Five new sulfur-containing compounds, with a new geometry (cis) of the propenyl moiety, and five known compounds were isolated from the roots of Ferula latisecta. The structures of these compounds, were elucidated on the basis of spectroscopic data including 1D and 2D NMR experiments and HRMS. All of the isolated compounds were tested against A2780, A549, HeLa, and HCT116 human cancer cell lines and some of them showed moderate cytotoxic activities.
October 21, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29062804/effect-of-the-methanolic-extracts-of-different-parts-of-ferula-assa-foetida-on-naloxone-induced-withdrawal-behavior-in-morphine-dependent-mice
#9
Mahnaz Khanavi, Sajad Maadani, Behnaz Farahanikia, Mahdieh Eftekhari, Mohammad Sharifzadeh
OBJECTIVE: Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetida on withdrawal syndrome in morphine-dependent mice. MATERIALS AND METHODS: Aerial parts, roots, and fruits of the plant were separately extracted with 80% MeOH. For induction of dependence, morphine (50, 50 and 75 mg/kg) was injected subcutaneously three times daily (10 am, 1 pm and 4 pm) for three days and a last dose of morphine (50 mg/kg) was administrated on the fourth day...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28959668/farnesiferol-c-induces-cell-cycle-arrest-and-apoptosis-mediated-by-oxidative-stress-in-mcf-7-cell-line
#10
Davoud Hasanzadeh, Majid Mahdavi, Gholamreza Dehghan, Hojjatollah Nozad Charoudeh
Farnesiferol C is one of the major compounds, isolated from Ferula asafoetida (a type of coumarins) and used for cancer treatment as a folk remedy. Treatment of many cancers depends on oxidative stress situation. In this study, we sought the hypothesis that oxidative stress induced by Farnesiferol C contribute to anticancer property and induce apoptosis in MCF-7, human breast cancer cell line. We investigated the effect of Farnesiferol C on oxidative stress by measurement of some enzymes activity including catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), as well as some parameters such as total thiol and ROS levels...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28959663/beyond-the-flavor-a-green-formulation-of-ferula-asafoetida-oleo-gum-resin-with-fenugreek-dietary-fibre-and-its-gut-health-potential
#11
Liju Vijayasteltar, I J Jismy, Ashil Joseph, Balu Maliakel, Ramadasan Kuttan, Krishnakumar I M
Albeit the fact that asafotida is a popular kitchen spice and Indian folklore medicine for gut disorders, its consumption at physiologically relevant dosage is greatly challenged by the unpleasant flavor characteristics. Herein we report a green approach to derive stable powder formulations of asafoetida gum with minimized taste and odor suitable for dietary applications and gut health-related disorders. Employing a water based ultrasound mediated gel-phase dispersion of asafoetida gum on fenugreek derived soluble galactomannan fibre matrix...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28948835/biological-activities-of-farnesiferol-c-a-review
#12
Jamal Kasaian, Ameneh Mohammadi
Farnesiferol C (FC) is a sesquiterpene coumarin, with a unique chemical structure, isolated from Ferula (Apiaceae) species including Ferula assa-foetida and Ferula szowitsiana. The compound is an important natural product with different biological activities. Recently, researchers have been interested in FC and begun to investigate its biological effects. They have shown that FC possesses various biological properties including cytotoxic, apoptotic, MDR reversal, antitumor, antimutagenic, and antiviral activity...
September 26, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28900317/evaluation-of-cytotoxicity-effects-of-oleo-gum-resin-and-its-essential-oil-of-ferula-assa-foetida-and-ferulic-acid-on-4t1-breast-cancer-cells
#13
Seyyed Majid Bagheri, Amir Abdian Asl, Ali Shams, Seyyed Ali Mirghanizadeh-Bafghi, Zeynab Hafizibarjin
BACKGROUND: Cancer causes significant morbidity and mortality and is a major public health problem worldwide. Breast cancer is a leading cause of cancer-associated mortality in women, and the incidence is also on the rise in the entire world. Medicinal plants have been an important source of several clinically useful anticancer agents. AIM: In this study, we studied the growth inhibitory effect of asafoetida and its essential oil and ferulic acid on antitumor activity using mouse breast cancer cell line...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28884956/osteoblast-cell-membrane-chromatography-coupled-with-liquid-chromatography-and-time-of-flight-mass-spectrometry-for-screening-specific-active-components-from-traditional-chinese-medicines
#14
Nani Wang, Qiaoyan Zhang, Hailiang Xin, Dan Shou, Luping Qin
A method using osteoblast membrane chromatography coupled with liquid chromatography and time-of-flight mass spectrometry was developed to recognize and identify the specific active components from traditional Chinese medicines. Primary rat osteoblasts were used for the preparation of the stationary phase in the cell chromatography method. Retention components from the cell chromatography were collected and analyzed by liquid chromatography with time-of-flight mass spectrometry. This method was applied in screening active components from extracts of four traditional Chinese medicines...
September 8, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28871937/-pleurotus-ferulae-polysaccharide-adjuvant-enhances-the-immune-infertility-of-czp3dna-vaccine
#15
Junyuan Lin, Ying Wang, Jinyu Li, Fuchun Zhang
Objective To investigate the effect of Pleurotus ferulae polysaccharide (PFP) as an adjuvant on the infertility induced by canine zona pellucida 3 (CZP3) DNA vaccine (pcDNA3-CZP3). Methods Female mice were intramuscularly immunized with pcDNA3-CZP3 alone or co-immunized with pcDNA3-CZP3 and aluminum adjuvant or PFP for three times. CZP3-specific antibody titers of antiserum were determined by ELISA. The maturation of dendritic cells (DCs) and the proliferation of T lymphocytes were detected by flow cytometry...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28839254/comparative-transcriptome-analysis-identified-candidate-genes-related-to-bailinggu-mushroom-formation-and-genetic-markers-for-genetic-analyses-and-breeding
#16
Yongping Fu, Yueting Dai, Chentao Yang, Peng Wei, Bing Song, Yang Yang, Lei Sun, Zhi-Wu Zhang, Yu Li
Bailinggu (Pleurotus tuoliensis) is a major, commercially cultivated mushroom and widely used for nutritional, medicinal, and industrial applications. Yet, the mushroom's genetic architecture and the molecular mechanisms underlying its formation are largely unknown. Here we performed comparative transcriptomic analysis during Bailinggu's mycelia, primordia, and fruiting body stages to identify genes regulating fruiting body development and develop EST-SSR markers assessing the genetic value of breeding materials...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28769736/three-new-species-and-one-new-subspecies-of-depressariinae-lepidoptera-from-europe
#17
Peter Buchner, Martin Corley, Jari Junnilainen
The species Depressaria albarracinella Corley, sp. n., Agonopterix carduncelli Corley, sp. n. and Agonopterix pseudoferulae Buchner & Junnilainen, sp. n. and the subspecies Depressaria saharae Gastón & Vives ssp. tabelli Buchner, ssp. n. are described. Depressaria albarracinella was first found in Spain in 1969 and recognised as apparently new but the specimens in NHMUK have remained undescribed. Additional Spanish material has been located in ZMUC and other collections and three specimens have been found from Greece...
2017: ZooKeys
https://www.readbyqxmd.com/read/28725631/biological-activities-and-medicinal-properties-of-asafoetida-a-review
#18
REVIEW
Augustine Amalraj, Sreeraj Gopi
Ferula asafoetida Linn. is a main source of asafoetida, a strong, tenacious and sulfurous odor, and oleo-gum resin of medicinal and nutritional importance. Asafoetida has been consumed as a spice and a folk medicine for centuries. Recent studies have shown several promising activities particularly relaxant, neuroprotective, memory enhancing, digestive enzyme, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, anticarcinogenic, anticancer, anticytotoxicity, antiobesity, anthelmintic and antagonistic effect...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28714345/chemical-composition-and-antioxidant-activity-of-aerial-parts-of-ferula-longipes-coss-ex-bonnier-and-maury
#19
Aicha Bouratoua, Assia Khalfallah, Chawki Bensouici, Zahia Kabouche, Abdulmagid Alabdul Magid, Dominique Harakat, Laurence Voutquenne-Nazabadioko, Ahmed Kabouche
This is the first study on the phytochemistry and antioxidant activity of Ferula longipes Coss. ex Bonnier and Maury (Apiaceae). A new flavonoid quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-[2-O-caffeoyl]-glucopyranoside (1), along with 10 known compounds kaempferol-3-O-α-L-rhamnopyranoside (2), quercetin-3-O-α-L-rhamnopyranoside (3), kaempferol-3-O-ß-D-glucopyranoside-7-O-α-L-rhamnopyranoside (4), isorhamnetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (5), quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (6), isorhamnetin-3,7-di-O-β-D-glucopyranoside (7), apigenin (8), apigenin-7-O-ß-D-glucopyranoside (9), 3,5-dicaffeoylquinic acid (10), deltoin (11) were isolated from the aerial parts of Ferula longipes Coss...
July 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28690055/antitumor-effect-of-ferula-assa-foetida-oleo-gum-resin-against-breast-cancer-induced-by-4t1-cells-in-balb-c-mice
#20
Seyyed Majid Bagheri, Amir Abdian-Asl, Mahin Taheri Moghadam, Maryam Yadegari, Aghdas Mirjalili, Fatemeh Zare-Mohazabieh, Haniyeh Momeni
BACKGROUND: Ferula assa foetida commonly consumed as a healthy beverage has been demonstrated to have various biological activities, including antioxidation, anti-obesity and anti-cancer. OBJECTIVE: Our study aims to investigate the antitumor effect of asafoetida in vivo using mouse mammary carcinoma 4T1 cells. MATERIALS AND METHODS: In the study, female BALB/c mice were divided into two groups (n = 6), which were control (untreated) and other group of mice with breast cancer treated with 100 mg/kg of asafoetida, respectively, by oral gavage...
July 2017: Journal of Ayurveda and Integrative Medicine
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