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F Ahmadi, Y Shokoohinia, Sh Javaheri, H Azizian
Recently, galbanic acid (GA), a sesquiterpenoid coumarin, has been introduced as an apoptotic and geno/cytotoxicity agent. In the present study, GA has been extracted from Ferula assa-foetida, a native medicinal plant in Iran, and characterized by (1)H NMR, mass spectroscopy. Additionally, spectroscopic studies have been performed in order to investigate its DNA-interaction mode. The electrochemical behavior of GA has been studied by cyclic voltammetry (CV) in various scan rates. In neutral media (pH=7.3) one irreversible cathodic peak was obtained at -1...
November 16, 2016: Journal of Photochemistry and Photobiology. B, Biology
Mahboob Alam, Ajmal Khan, Abdul Wadood, Ayesha Khan, Shumaila Bashir, Akhtar Aman, Abdul Khaliq Jan, Abdur Rauf, Bashir Ahmad, Abdur Rahman Khan, Umar Farooq
[This corrects the article on p. 26 in vol. 7, PMID: 26909039.].
2016: Frontiers in Pharmacology
Milene Aparecida Andrade, Clênia Dos Santos Azevedo, Flávia Nader Motta, Maria Lucília Dos Santos, Camila Lasse Silva, Jaime Martins de Santana, Izabela M D Bastos
BACKGROUND: The current chemotherapy for cutaneous leishmaniosis (CL) has a series of drug limitations such as toxic side effects, long duration, high costs and drug resistance, which requires the development of new drugs or effective alternatives to the CL treatment. Essential oils (EOs) are complex mixtures of secondary metabolites from various plants. It has been shown that several EOs, or their constituents, have inhibitory activity against protozoa. Thus, this study aims to evaluate the biological activity of different essential oils (EOs) on Leishmania (L...
November 8, 2016: BMC Complementary and Alternative Medicine
Eduardo Bracho-Blanchet, Mónica Langarica-Bulos, Roberto Dávila-Pérez, Emilio Fernández-Portilla, Cristian Zalles-Vidal, Jaime Nieto-Zermeño
Objetivo: Mostrar la eficacia de la FI para prolongar el tiempo libre de oclusión intestinal quirúrgica en niños con abdomen hostil secundario a bridas posquirúrgicas. Método: Análisis retrospectivo de FI por abdomen hostil de 2000 a 2011 y su seguimiento a largo plazo. Comparamos el tiempo libre de oclusión quirúrgica antes y después de la FI. Resultados: Se incluyeron 20 FI en 19 pacientes. Predominaron las causas congénitas, la mediana de edad en la cirugía fue de 6 meses, todos tenían cirugías previas con mediana de tres, y dos de ellas fueron por oclusión intestinal previa...
October 2016: Gaceta Médica de México
Mohsen Rashidi, Seyed Ali Ziai, Taraneh Moini Zanjani, Ahad Khalilnezhad, Hamidreza Jamshidi, Davar Amani
BACKGROUND: Resistance to chemotherapy is a growing concern, thus natural anticancer agents are drawing the attention of many scientists and clinicians. One natural anticancer agent, umbelliprenin, is a coumarin produced by many species of Ferula. OBJECTIVES: We aimed to examine the inhibitory effect of umbelliprenin on human and mouse bone marrow-derived stem cells (BMDSCs), peripheral blood mononuclear cells (PBMCs), and different cancer cell lines. MATERIALS AND METHODS: In this in vitro experimental study, the HT29, CT26, MCF-7, 4T1, A172, and GL26 cancer cells and human and mouse BMDSCs and PBMCs were cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum (FBS), incubated at 37°C for 24 hours in a 5% CO2 atmosphere, and then were treated with different concentrations of umbelliprenin dissolved in dimethyl sulfoxide (DMSO) (3, 6, 12, 25, 50, 100, and 200 µg/mL) for 24, 48, and 72 hours at 37°C...
July 2016: Iranian Red Crescent Medical Journal
Adnan Amin, Emmy Tuenter, Paul Cos, Louis Maes, Vassiliki Exarchou, Sandra Apers, Luc Pieters
The exudate of Ferula narthex Boiss. (Apiaceae) is widely used in the Indian subcontinent as a spice and because of its health effects. Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 8'-O-acetyl-asacoumarin A, 10'R-karatavacinol and 10'R-acetyl-karatavacinol. Based on its use in infectious and diabetic conditions, the isolated constituents were evaluated for antimicrobial and antiglycation activities. Some compounds showed activity against protozoal parasites, asacoumarin A being the most active one against Plasmodium falciparum K1 (IC50 1...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mansour Znati, Insaf Filali, Aymen Jabrane, Joseph Casanova, Jalloul Bouajila, Hichem Ben Jannet
Essential oil of the seeds from the endemic Tunisian plant Ferula tunetana Pomel ex Batt. was analyzed for its chemical composition and screened for its antimicrobial, antioxidant and antigerminative properties. The chemical composition of the isolated oil is reported for the first time. According to the GC/FID, GC-MS and (13) C NMR analysis results; eighteen compounds were identified accounting for 84.6% of the total oil. The chemical composition of this essential oil was characterized by the presence of a high proportion of monoterpene hydrocarbons (77...
September 16, 2016: Chemistry & Biodiversity
Igor A Schepetkin, Svetlana V Kushnarenko, Gulmira Özek, Liliya N Kirpotina, Pritam Sinharoy, Gulzhakhan A Utegenova, Karime T Abidkulova, Temel Özek, Kemal Hüsnü Can Başer, Anastasia R Kovrizhina, Andrei I Khlebnikov, Derek S Damron, Mark T Quinn
Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca(2+)]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7...
September 28, 2016: Journal of Agricultural and Food Chemistry
Majid Kiyanmehr, Mohammad Hossein Boskabady, Mohammad Reza Khazdair, Milad Hashemzehi
BACKGROUND: The contribution of histamine (H1) receptors inhibitory and/or β-adrenoceptors stimulatory mechanisms in the relaxant property of Ferula assa-foetida. (F. asafoetida) was examined in the present study. METHODS: We evaluated the effect of three concentrations of F. asafoetida extract (2.5, 5, and 10 mg/mL), a muscarinic receptors antagonist, and saline on methacholine concentration-response curve in tracheal smooth muscles incubated with β-adrenergic and histamine (H1) (group 1), and only β-adrenergic (group 2) receptors antagonists...
January 2016: Malaysian Journal of Medical Sciences: MJMS
Min-Jae Kang, Keun Ki Kim, Byoung Yil Son, Soo-Wan Nam, Pyung-Gyun Shin, Gun-Do Kim
Adipogenesis is one of cellular processes and highly controlled program. Nowadays, inhibition of adipogenesis has received attention for effective way to regulate obesity. In current study, we investigated the inhibition effect of chloroform extract of Pleurotus eryngii var. ferulae 'Beesan No. 2' (CEBT) on adipogenesis in 3T3-L1 murine preadipocytes. Pleurotus eryngii var. ferulae is one of many varieties of King oyster mushroom and has been reported that it has various biological activities, including anti-tumor and anti-inflammation...
July 27, 2016: Journal of Microbiology and Biotechnology
L Aldaghi, A Rad, A Arab, J Kasaian, M Iranshahi, A S Sadr, F Soltani
Background: Cancer is one of the leading causes of death worldwide. Despite certain advances in cancer therapy, still there is considerable demand for developing efficient therapeutic agents. Nowadays, there is a rising interest in the use of natural-based anti-cancer drugs. In this study, the cytotoxicity of farnesiferol C and microlobin isolated from Ferula szowitsiana was investigated against MCF-7, HeLa and KYSE cancer cell lines. In addition, the mechanism of binding of these compounds to apoptotic proteins (Bax, Bak and Bcl-2) was analyzed by an in silico method...
October 2016: Drug Research
Yachao Xing, Ning Li, Di Zhou, Gang Chen, Kun Jiao, Wenli Wang, Yingying Si, Yue Hou
Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer's disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identified sixteen bioactive sesquiterpene coumarins (two new and fourteen known ones) in the effective extract of Ferula sinkiangensis...
July 15, 2016: Planta Medica
E P Nartshuk
A new species, Polyodaspis ferulae n. sp., from Central Asia (Uzbekistan) is described. The species was collected on inflorescences of Ferula foetida (Apiaceae). Siphonella levicola Becker in Becker and Stein, 1913 described from Iran is synonymized with Polyodaspis sulcicollis (Meigen, 1838) based on investigation of the holotype. A key to 9 species of the genus Polyodaspis Duda, 1933 is proposed with illustrations of male genitalia. Polyodaspis and Anacamptoneurum Becker, 1903 are treated as separate genera...
2016: Zootaxa
Najla O Zarmouh, Samia S Messeha, Faisel M Elshami, Karam F A Soliman
AIMS: Monoamine oxidase-B inhibitors (MAO-BIs) are used for the initial therapy of Parkinson's disease. Also, MAO-BIs have shown to be effective neuroprotective agents in several neurodegenerative diseases. However, some concerns exist regarding the long-term use of these compounds. Meanwhile, natural compounds showed potential MAO-B selective inhibitions. To date, few selective natural MAO-BIs have been identified. Therefore, the current study is designed to identify plants with potent and specific MAO-B inhibition...
May 2016: European Journal of Medicinal Plants
Roghieh Safari, Seyed Hossein Hoseinifar, Shabnam Nejadmoghadam, Ali Jafar
A 8-weeks feeding trial was conducted to examine the effects of different levels (0, 0.5, 1 and 2%) of dietary Ferula (Ferula assafoetida) on expression of antioxidant enzymes (GSR, GPX and GSTA), immune (TNF-alpha, IL1B, IL- 8 and LYZ) and growth (GH, IGF1 and Ghrl) genes as well as cutaneous mucus and serum non-specific immune response in common carp. The results revealed Ferula significantly increased antioxidant gene expression (GSR and GSTA) in a dose dependent manner (P < 0.05). The expression of immune growth related genes were significantly higher in Ferula fed fish compared control group (P < 0...
August 2016: Fish & Shellfish Immunology
Jinyu Li, Jinyao Li, Adila Aipire, JiaoJiao Luo, Pengfei Yuan, Fuchun Zhang
Our previous study reported that the combination of Pleurotus ferulae water extract (PFWE) and CpG (PFWE+CpG) enhanced the maturation and function of dendritic cells (DCs). Here, we investigated the effects of PFWE+CpG on the immune responses and antitumor efficacy of DC-based vaccine. We observed that all of HPV E6 and E7 peptides pulsed DCs (HPV-immature DCs, HPV+PFWE-, +CpG- or +PFWE+CpG-DCs) induced antigen-specific CD8(+) T cell responses and HPV+PFWE+CpG-DCs induced highest level of CD8(+) T cell responses...
June 30, 2016: Vaccine
Xiang Zhang, Dan Lin, Rong Jiang, Hongzhong Li, Jingyuan Wan, Hongyuan Li
Metastasis, which frequently occurs in breast cancer, is the major cause of mortality; therefore, new treatment strategies are urgently needed. Ferulic acid, isolated from Ferula foetida, a perennial herb, has shown antineoplastic activity in various types of cancers, such as colon and lung cancer, and central nervous system tumors. However, its potential role in suppressing breast cancer metastasis has not been fully understood. In the present study, we evaluated the antitumor activity of ferulic acid in breast cancer cell line-based in vitro and in vivo models...
July 2016: Oncology Reports
Jun-Hui Choi, Dae-Won Kim, Seung Kim, Sung-Jun Kim
A fibrinolytic metalloprotease with in vitro fibrinolytic effects was purified from the edible mushroom, Pleurotus ferulae using several chromatography steps including anion- and ion-exchange, gel filtration, and fast protein liquid chromatography (FPLC) columns. The molecular mass of the enzyme was estimated to be 20.0 kDa, as determined using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and fibrin zymography. The protease was active at 50 °C, and pH 4.0, 5.0, and 8.0. The fibrinolytic activity of the enzyme was inhibited by EGTA, and strongly inhibited by two metal ions, Cu and Mg...
May 2, 2016: Preparative Biochemistry & Biotechnology
Adel Al-Marby, Chukwunonso Ecc Ejike, Muhammad Jawad Nasim, Nasser A Awadh-Ali, Rwaida A Al-Badani, Ghanem Ma Alghamdi, Claus Jacob
AIM/BACKGROUND: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. MATERIALS AND METHODS: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays...
March 2016: Journal of Intercultural Ethnopharmacology
Mohaddese Mahboubi
Ferula gummosa with the Persian name of Barijeh is reputed due to its traditional history. The aim of this review was to investigate traditional and novel applications of this valuable plant. Relevant databases (PubMed, ScienceDirect®, Wiley, Taylor & Francis, and Springer) and local books on ethnopharmacology of F. gummosa were studied without limitation up to January 1, 2015, and the results of these studies were collected and reviewed. F. gummosa has been traditionally used as an antiseptic, an anti-flatulent, an anti-seizure agent, an anti-spasm, a pain killer, an inflammation reliever, and a tonic of memory enhancement...
November 2016: Journal of Dietary Supplements
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