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https://www.readbyqxmd.com/read/28110443/aerobic-endurance-training-does-not-protect-bone-against-poorly-controlled-type-1-diabetes-in-young-adult-rats
#1
Tom J Hazell, T Dylan Olver, Hana Kowalchuk, Matthew W McDonald, Adwitia Dey, Kenneth N Grisé, Earl G Noble, C W James Melling, Paula Lavery, Hope A Weiler
Streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) decreases trabecular bone volume and bone strength in rodents. The current study investigated the potential protective effects of aerobic endurance training (AET) on bone in STZ-induced T1DM young adult rats. Sixty-four 8-week-old male Sprague-Dawley rats were randomly divided into 4 groups of 16: control non-T1DM sedentary (CS) and exercised (CX), T1DM sedentary (DS) and exercised (DX). Blood glucose was maintained at 9-15 mmol/L using subcutaneously implanted insulin pellets (Linplant, Linshin Canada, Inc...
January 21, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28110332/role-of-insulin-in-placental-transport-of-nutrients-in-gestational-diabetes-mellitus
#2
María Ruiz-Palacios, Antonio José Ruiz-Alcaraz, María Sanchez-Campillo, Elvira Larqué
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with increased fetal adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin receptors and maternal insulin can activate its signaling pathways, affecting the transport of nutrients to the fetus. However, the effects of diet or insulin treatment on the placental pathophysiology of GDM are unknown. SUMMARY: There are very few studies on possible defects in the insulin signaling pathway in the GDM placenta...
January 21, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28110316/insensitivity-of-pi3k-akt-gsk3-signaling-in-peripheral-blood-mononuclear-cells-of-age-related-macular-degeneration-patients
#3
Liu Xunxian, Yao Zemin
Our recent studies with cultured retinal pigment epithelium cells suggested that overexpression of interleukin 17 receptor C (IL-17RC), a phenomenon observed in peripheral blood and chorioretinal tissues with age-related macular degeneration (AMD), was associated with altered activation of phosphatidylinositide 3-kinase (PI3K), Akt, and glycogen synthase kinase 3 (GSK3). We wondered whether or not altered PI3K, Akt, and GSK3 activities could be detected in peripheral blood mononuclear cells (PBMC) obtained from AMD patients...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28110219/tgf-%C3%AE-engineered-mesenchymal-stem-cells-tgf-%C3%AE-mscs-for-treatment-of-type-1-diabetes-t1d-mice-model
#4
Saeed Daneshmandi, Mohammad Hossein Karimi, Ali Akbar Pourfathollah
OBJECTIVE: Mesenchymal stem cells (MSCs) are advantageous candidates for cell therapy of Type 1 diabetes (T1D). Considering immunomodulatory effect of MSC, in this study, we engineered MSCs with TGF-β gene to increase MSC potency for T1D therapy in mouse model. MATERIALS AND METHODS: Two plans were designed for prevention and treatment of diabetes, respectively. In both of them, MSCs were injected i.v. and then, the diabetes features including serum insulin, blood glucose, glucose tolerance, splenocytes proliferation, and IL-4/IFN-γ production were evaluated...
January 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28110155/first-in-man-study-with-a-novel-pegylated-recombinant-human-insulin-like-growth-factor-i
#5
H Kletzl, A Guenther, A Höflich, C Höflich, J Frystyk, R F Staack, E Schick, C Wandel, N Bleich, F Metzger
OBJECTIVE: This study is a first time assessment of safety and tolerability, pharmacokinetics, and pharmacodynamics of RO5046013 in human, in comparison with unmodified rhIGF-I. DESIGN: The study was conducted as a single-center, randomized, double-blinded, placebo-controlled, single ascending dose, parallel group study in a clinical research unit in France. A total of 62 healthy volunteers participated in this clinical trial. RO5046013 was given as single subcutaneous injection, or as intravenous infusion over 48h, at ascending dose levels...
January 10, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28110133/identification-of-potential-antioxidant-indices-by-biogenic-gold-nanoparticles-in-hyperglycemic-wistar-rats
#6
Manimegalai Sengani, V Devirajeswari
Oxidative stress is a crucial factor in diabetes, where the abnormal metabolic ambience leads to hyperglycemia resulting in the onset of several vascular complications. Under homeostasis, innate antioxidants efficiently inhibit the oxidative stress, thereby restrain further progression of diabetes. In the present study, a potential antioxidant marker was identified from hepatic tissue of diabetic Wistar rats after oral administration of biogenic gold nanoparticles (GNPs). Diabetic animals treated with GNPs showed increase in insulin level and subsequently reduced the concentration of blood glucose level to normal...
January 15, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28110120/effects-of-two-different-dialytic-treatments-on-inflammatory-markers-in-people-with-end-stage-renal-disease-with-and-without-type-2-diabetes-mellitus
#7
Giuseppe Derosa, Carmelo Libetta, Pasquale Esposito, Ilaria Borettaz, Carmine Tinelli, Angela D'angelo, Pamela Maffioli
This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensitivity C-reactive protein (hs-CRP), fibrinogen, lipoprotein (a) [Lp(a)], metalloproteinases-2, and -9 (MMP-2 and MMP-9), and soluble receptor for advanced glycation end products (sRAGE). Considering the all sample, we observed a decrease of sRAGE with BHD, but not with HDF...
January 18, 2017: Cytokine
https://www.readbyqxmd.com/read/28109969/independent-of-cirrhosis-hepatocellular-carcinoma-risk-is-increased-with-diabetes-and-metabolic-syndrome-a-retrospective-cohort-study
#8
Allison Kasmari, Amy Welch, Guodong Liu, Doug Leslie, Thomas McGarrity, Thomas Riley
BACKGROUND: Hepatocellular carcinoma is the most common primary liver malignancy, commonly a sequelae of hepatitis C infection, but can complicate cirrhosis of any cause. Whether metabolic syndrome and its components, type II diabetes (), hypertension, and hyperlipidemia increase the risk of hepatocellular carcinoma independent of cirrhosis is unknown. METHODS: Retrospective cohort study was conducted using the MarketScan® insurance claims database from 2008-2012...
January 18, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28109957/adoptive-transfer-of-mrna-transfected-t-cells-redirected-against-diabetogenic-cd8%C3%A2-t-cells-can-prevent-diabetes
#9
Sigal Fishman, Mark D Lewis, L Khai Siew, Evy De Leenheer, Dimitri Kakabadse, Joanne Davies, Doron Ziv, Alon Margalit, Nathan Karin, Gideon Gross, F Susan Wong
Chimeric major histocompatibility complex (MHC) molecules supplemented with T cell receptor (TCR) signaling motifs function as activation receptors and can redirect gene-modified T cells against pathogenic CD8 T cells. We have shown that β2 microglobulin (β2m) operates as a universal signaling component of MHC-I molecules when fused with the CD3-ζ chain. Linking the H-2K(d)-binding insulin B chain peptide insulin B chain, amino acids 15-23 (InsB15-23) to the N terminus of β2m/CD3-ζ, redirected polyclonal CD8 T cells against pathogenic CD8 T cells in a peptide-specific manner in the non-obese diabetic (NOD) mouse...
January 18, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28109916/polyphenolic-enriched-extract-of-cassia-glauca-lamk-improves-streptozotocin-induced-type-1-diabetes-linked-with-partial-insulin-resistance-in-rats
#10
V P Veerapur, V Pratap, B S Thippeswamy, P Marietta, P Bansal, P V Kulkarni, V H Kulkarni
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally Cassia glauca (CG) has been used to treat diabetes. AIM OF THE STUDY: The study was undertaken to evaluate anti-diabetic and antioxidant activity of poly phenolic enriched extract of CG in standardized streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: The effect of ethanol (CGE) and water (CGW) extracts of CG (200 and 400mg/kg) treatment were evaluated in STZ (50mg/kg, iv) induced diabetic rats...
January 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28109900/microcystin-lr-retards-gonadal-maturation-through-disrupting-the-growth-hormone-insulin-like-growth-factors-system-in-zebrafish
#11
Jie Hou, Yujing Su, Wang Lin, Honghui Guo, Ping Xie, Jun Chen, Zemao Gu, Li Li
Recent studies have documented that microcystins (MCs) have potential toxic effects on growth and reproduction in fish. However, no systematic data exist on whether MCs cause gonadal development retardation through disrupting the growth hormone/insulin-like growth factors (GH/IGFs) system. To this end, zebrafish hatchlings (5 d post-fertilization) were exposed to 0, 0.3, 3 and 30µg/L microcystin-LR (MC-LR) for 90 d until they reached sexual maturity. Life-cycle exposure to MC-LR caused delayed ovarian maturation and sperm development along with ultrapathological lesions in the brain and liver...
January 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28109892/lipid-oxidation-products-in-the-pathogenesis-of-non-alcoholic-steatohepatitis
#12
REVIEW
Francesco Bellanti, Rosanna Villani, Antonio Facciorusso, Gianluigi Vendemiale, Gaetano Serviddio
Non-alcoholic fatty liver disease (NAFLD) is the major public health challenge for hepatologists in the twenty-first century. NAFLD comprises a histological spectrum ranging from simple steatosis or fatty liver, to steatohepatitis, fibrosis, and cirrhosis. It can be categorized into two principal phenotypes: (1) non-alcoholic fatty liver (NAFL), and (2) non-alcoholic steatohepatitis (NASH). The mechanisms of NAFLD progression consist of lipid homeostasis alterations, redox unbalance, insulin resistance, and inflammation in the liver...
January 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28109835/gut-microbiota-a-player-in-aging-and-a-target-for-anti-aging-intervention
#13
REVIEW
Alexander M Vaiserman, Alexander K Koliada, Francesco Marotta
Aging-associated alterations in composition, diversity and functional features of intestinal microbiota are well-described in the modern literature. They are suggested to be caused by an age-related decline in immune system functioning (immunosenescence) and a low-grade chronic inflammation (inflammaging), which accompany many aging-associated pathologies. The microbiota-targeted dietary and probiotic interventions have been shown to favorably affect the host health and aging by an enhancement of antioxidant activity, improving immune homeostasis, suppression of chronic inflammation, regulation of fat deposition and metabolism and prevention of insulin resistance...
January 18, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28109823/divergent-regulation-of-insulin-like-growth-factor-binding-protein-genes-in-cultured-atlantic-salmon-myotubes-under-different-models-of-catabolism-and-anabolism
#14
Daniel Garcia de la Serrana, Eduardo N Fuentes, Samuel A M Martin, Ian A Johnston, Daniel J Macqueen
Much attention has been given to insulin-like growth factor (Igf) pathways that regulate the balance of skeletal muscle protein synthesis and breakdown in response to a range of extrinsic and intrinsic signals. However, we have a less complete understanding of how the same signals modulate muscle mass upstream of such signalling, through a family of functionally-diverse Igf-binding proteins (Igfbps) that modify the availability of Igfs to the cell receptor Igf1r. We exposed cultured myotubes from Atlantic salmon (Salmo salar L...
January 18, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28109601/effects-of-rumen-protected-capsicum-oleoresin-on-immune-responses-in-dairy-cows-intravenously-challenged-with-lipopolysaccharide
#15
J Oh, M Harper, F Giallongo, D M Bravo, E H Wall, A N Hristov
The objective of this experiment was to investigate the effects of rumen-protected Capsicum oleoresin (RPC) on productivity and immune responses including feed intake, milk yield and composition, white and red blood cells, lipid peroxidation, and blood concentration of cortisol, haptoglobin, glucose, and insulin in lactating dairy cows experimentally challenged with lipopolysaccharide (LPS). The experiment was a replicated 3 × 3 Latin square design with 9 multiparous Holstein cows in three 28-d periods. Treatments were 0 (control), 100, and 200 mg of RPC/cow per day, mixed with small portions of the total mixed ration and top-dressed...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109592/short-communication-limitations-of-glucose-tolerance-tests-in-the-assessment-of-peripheral-tissue-insulin-sensitivity-during-pregnancy-and-lactation-in-dairy-heifers
#16
J De Koster, M Van Eetvelde, K Hermans, W Van den Broeck, M Hostens, G Opsomer
The aim of the present study was to point at the limitations of glucose tolerance tests (GTT) to assess peripheral tissue insulin sensitivity in dairy heifers in different physiological states (pregnancy and lactation). Intravenous GTT were performed in 5 nonpregnant, nonlactating heifers, 5 heifers at the end of pregnancy (12-7 d before calving), and 5 lactating primiparous cows (11-14 d after calving). Glucose and insulin concentrations were determined and area under the curve (AUC) and clearance rate of glucose and insulin were calculated...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109586/elevation-of-blood-%C3%AE-hydroxybutyrate-concentration-affects-glucose-metabolism-in-dairy-cows-before-and-after-parturition
#17
M Zarrin, L Grossen-Rösti, R M Bruckmaier, J J Gross
Recent studies in mid- and late-lactation dairy cows showed that β-hydroxybutyrate (BHB) infusion had a considerable effect on glucose metabolism and immune response during intramammary lipopolysaccharide challenge. The objective of the present study was to infuse BHB during the dry period and after parturition to investigate the effects of elevated plasma BHB concentrations on metabolism and endocrine changes in transition dairy cows. The hypothesis tested was that regulation of glucose metabolism would change at different physiological stages and an additional elevation of BHB concentration would alter glucose concentration...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109299/in-utero-exposure-to-germinated-brown-rice-and-its-oryzanol-rich-extract-attenuated-high-fat-diet-induced-insulin-resistance-in-f1-generation-of-rats
#18
Hadiza Altine Adamu, Mustapha Umar Imam, Der-Jiun Ooi, Norhaizan Mohd Esa, Rozita Rosli, Maznah Ismail
BACKGROUND: The development of insulin resistance is multifactorial, with maternal pre- and postnatal nutrition having significant influences. In this regard, high fat diet (HFD) feeding in pregnancy has been shown to increase risks of metabolic diseases. Thus, we investigated the effects of supplementation of HFD with germinated brown rice (GBR) and GBR-derived gamma oryzanol-rich extract (OE) on insulin resistance and its epigenetic implications in pregnant rats and their offsprings...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28109166/a-novel-dual-amylin-and-calcitonin-receptor-agonist-dacra-kbp-089-induces-weight-loss-through-a-reduction-in-fat-but-not-lean-mass-while-improving-food-preference
#19
Sofie Gydesen, Sara Toftegaard Hjuler, Zenia Freving, Kim Vietz Andreassen, Nina Sonne, Lars I Hellgren, Morten Asser Karsdal, Kim Henriksen
BACKGROUND AND PURPOSE: Obesity and associated co-morbidities, such as type 2 diabetes and non-alcoholic fatty liver disease, are major health challenges - hence, development of weight loss therapies with the ability to reduce the co-morbidities is key. EXPERIMENTAL APPROACH: The effect of the dual amylin and calcitonin receptor agonist (DACRA), KBP-089, on bodyweight, glucose homeostasis, and fatty acid accumulation in liver and muscle tissue, food preference was investigated...
January 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28109147/-co-culture-with-umbilical-cord-mesenchymal-stem-cells-promotes-the-synthesis-and-mechnism-of-milk-protein-in-bovine-mammary-epithelial-cells
#20
Yankun Zhao, Wei Shao, Chenglong Luo, Kaile Wu, Xiong Yu
Objective To explore the possible mechanism of umbilical cord mesenchymal stem cells (UCMSCs) regulating milk protein synthesis in bovine mammary gland epithelial cells (BMECs). Methods UCMSCs and BMECs were co-cultured by double-chamber Transwell(TM), and other BMECs were cultured alone as a control group. Insulin like growth factor 1 receptor (IGF-1R) inhibitor AG1024 was used to treat cells. IGF-1, β casein (CSN2) and κ casein (CSN3) content in the supernatants were determined by ELISA; the relative expression abundance of Janus kinase and signal transducer and activator of transcription factor (JAK/STAT) signaling pathway-related genes were detected by quantitative real-time PCR (qRT-PCR); and after the cells were treated with JAK2 signal blocker AG490, qRT-PCR was performed to test the relative expression abundance of CSN2 and CSN3 mRNAs...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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