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https://www.readbyqxmd.com/read/28419583/a-comparison-of-multi-factor-scoring-systems-and-single-serum-markers-for-the-early-prediction-of-the-severity-of-acute-pancreatitis
#1
Wen-Hua He, Yin Zhu, Yong Zhu, Qi Jin, Hong-Rong Xu, Zhi-Juan Xion, Min Yu, Liang Xia, Pi Liu, Nong-Hua Lu
BACKGROUND: The purpose of this study was to clarify whether the current scoring systems and single serum markers used in pancreatitis remain applicable for the early prediction of infected pancreatic necrosis (IPN), the severity and mortality of acute pancreatitis (AP) in accordance with the revised Atlanta and determinant-based classifications. METHODS: Demographic, clinical, and laboratory data from 708 consecutive patients with AP were prospectively collected between January 2011 and December 2012...
April 17, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28415489/design-of-salecan-containing-semi-ipn-hydrogel-for-amoxicillin-delivery
#2
Xiaoliang Qi, Wei Wei, Junjian Li, Ting Su, Xihao Pan, Gancheng Zuo, Jianfa Zhang, Wei Dong
Salecan is a new linear extracellular β-glucan. The unique structure and beneficial properties of Salecan makes it an appealing material in biomedical applications. In this work, novel drug devices based on Salecan in a hydrogel matrix of poly(N-(3-dimethylaminopropyl)acrylamide-co-acrylamide) (Salecan/PDA) were fabricated via free radical polymerization for controlled release of amoxicillin. It was demonstrated that amoxicillin was efficiently encapsulated into the developed hydrogels and released in a Salecan dose-dependent and pH-sensitive manner...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415481/modeling-of-drug-release-behavior-of-ph-and-temperature-sensitive-poly-nipaam-co-aac-ipn-hydrogels-using-response-surface-methodology-and-artificial-neural-networks
#3
Sanogo Brahima, Cihangir Boztepe, Asim Kunkul, Mehmet Yuceer
An interpenetrated polymer network (IPN) poly(NIPAAm-co-AAc) hydrogel was synthesized by two polymerization method: emulsion and solution polymerization. The pH- and temperature-sensitive hydrogel was loaded by swelling with riboflavin drug, a B2 vitamin. The release of riboflavin as a function of time has been achieved under different pH and temperature environments. The determination of experimental conditions and the analysis of drug delivery results were achieved using response surface methodology (RSM)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28411344/the-effect-of-a-novel-minimally-invasive-strategy-for-infected-necrotizing-pancreatitis
#4
Zhihui Tong, Xiao Shen, Lu Ke, Gang Li, Jing Zhou, Yiyuan Pan, Baiqiang Li, Dongliang Yang, Weiqin Li, Jieshou Li
BACKGROUND: Step-up approach consisting of multiple minimally invasive techniques has gradually become the mainstream for managing infected pancreatic necrosis (IPN). In the present study, we aimed to compare the safety and efficacy of a novel four-step approach and the conventional approach in managing IPN. METHODS: According to the treatment strategy, consecutive patients fulfilling the inclusion criteria were put into two time intervals to conduct a before-and-after comparison: the conventional group (2010-2011) and the novel four-step group (2012-2013)...
April 14, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28385222/alginate-polyvinyl-alcohol-based-interpenetrating-polymer-network-for-prolonged-drug-therapy-optimization-and-in-vitro-characterization
#5
Hina Anwar, Mahmood Ahmad, Muhammad Usman Minhas, Sahrish Rehmani
A new natural and synthetic polymeric blend to form interpenetrating polymer network (IPN) hydrogels was synthesized utilizing sodium alginate and PVA as polymers by free radical polymerization employing 2-Acylamido-2-methylpropane-sulfonic acid as monomer (AMPS) and tramadol HCl as model drug through 3(2) level full factorial design to evaluate the impact of selected independent factors i.e. polymer (sodium alginate) and monomer (AMPS) contents on swelling index at 18th hour, percent drug release at 18th hour, time required for 80% drug release and drug entrapment efficiency as dependent variables...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28368384/glp-1-acts-on-habenular-avoidance-circuits-to-control-nicotine-intake
#6
Luis M Tuesta, Zuxin Chen, Alexander Duncan, Christie D Fowler, Masago Ishikawa, Brian R Lee, Xin-An Liu, Qun Lu, Michael Cameron, Matthew R Hayes, Theodore M Kamenecka, Matthew Pletcher, Paul J Kenny
Tobacco smokers titrate their nicotine intake to avoid its noxious effects, sensitivity to which may influence vulnerability to tobacco dependence, yet mechanisms of nicotine avoidance are poorly understood. Here we show that nicotine activates glucagon-like peptide-1 (GLP-1) neurons in the nucleus tractus solitarius (NTS). The antidiabetic drugs sitagliptin and exenatide, which inhibit GLP-1 breakdown and stimulate GLP-1 receptors, respectively, decreased nicotine intake in mice. Chemogenetic activation of GLP-1 neurons in NTS similarly decreased nicotine intake...
April 3, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28316142/evolutionary-ecology-of-beta-lactam-gene-clusters-in-animals
#7
Wouter Suring, Karen Meusemann, Alexander Blanke, Janine Mariën, Tim Schol, Valeria Agamennone, Anna Faddeeva-Vakhrusheva, Matty P Berg, Bram Brouwer, Nico M van Straalen, Dick Roelofs
Beta-lactam biosynthesis was thought to occur only in fungi and bacteria, but we recently reported the presence of isopenicillin N synthase in a soil-dwelling animal, Folsomia candida. However, it has remained unclear whether this gene is part of a larger beta-lactam biosynthesis pathway and how widespread the occurrence of penicillin biosynthesis is among animals. Here, we analyzed the distribution of beta-lactam biosynthesis genes throughout the animal kingdom and identified a beta-lactam gene cluster in the genome of F...
March 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28285053/co2-responsive-polyacrylamide-microspheres-with-interpenetrating-networks
#8
Meng Mu, Hongyao Yin, Yujun Feng
HYPOTHESIS: CO2-responsive microspheres fabricated via co-polymerization protocol are attractive due to their promising applications. However, the inevitable particles-agglomeration restrained their further utilizations. Towards this challenge, interpenetrating network (IPN) protocol would be a potential choice to construct the "intelligent" microspheres, which presents superiority in comparison with co-polymerization mode. EXPERIMENTS: A series of CO2-responsive microspheres with polyacrylamide (PAM)/poly(dimethyl aminopropyl methacrylamide) (PDMAPMA) IPN-structure were fabricated via inverse seed suspension polymerization by adjusting DMAPMA loading and crosslinking-degree of seeds...
July 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28262316/an-imprinted-interpenetrating-polymer-network-for-microextraction-in-packed-syringe-of-carbamazepine
#9
Sara Asgari, Habib Bagheri, Ali Es-Haghi, Roya AminiTabrizi
An imprinted interpenetrating polymer network (IPN) was synthesized and used as a medium for isolation of carbamazepine from urine samples. The polymer network consisted of a homogeneous polystyrene-sol gel hybrid constructed by in-situ radical polymerization method. In this process, within the sol-gel reaction duration, styrene monomer could penetrate into the reaction mixture and after the polymerization initiation, a monolithic IPN structure was prepared. The scanning electron microscopy (SEM) image and energy dispersive spectroscopy (EDX) are indications of the polystyrene dispersion at nano- to micro-meter level in the sol gel matrix...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28258454/indeterminate-pulmonary-nodules-in-resected-liver-metastases-from-colorectal-cancer-a-comparison-of-patient-outcomes
#10
V Robertson, C P Neal, M Jones, A R Dennison, G Garcea
AIMS: Hepatic metastasectomy remains the only potentially curative treatment for colorectal liver metastases (CRLM). Some of these patients develop indeterminate pulmonary nodules (IPNs). This study aimed to compare outcomes of patients with and without IPN undergoing resection of CRLM to ascertain whether their presence is clinically significant. METHODS: Cases and controls were identified from a prospectively maintained database of CRLM resections. Patients with staging radiology demonstrating IPNs were included as cases...
March 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28244113/clinical-and-mutational-spectrum-of-japanese-patients-with-charcot-marie-tooth-disease-caused-by-gdap1-variants
#11
Akiko Yoshimura, Jun-Hui Yuan, Akihiro Hashiguchi, Yu Hiramatsu, Masahiro Ando, Yujiro Higuchi, Tomonori Nakamura, Yuji Okamoto, Kiichiro Matsumura, Toshiaki Hamano, Noriko Sawaura, Yoshimitsu Shimatani, Satoko Kumada, Yoshinori Okumura, Junichi Miyahara, Yoshitaka Yamaguchi, Shigekazu Kitamura, Kazuhiro Haginoya, Jun Mitsui, Hiroyuki Ishiura, Shoji Tsuji, Hiroshi Takashima
Mutations in GDAP1 are responsible for heterogeneous clinical and electrophysiological phenotypes, with autosomal dominant or recessive inheritance pattern. From April 2007 to October 2014, using three state-of-art technologies, we conducted gene panel sequencing in a cohort of 1,030 patients with inherited peripheral neuropathies (IPNs), and 398 mutation-negative cases were further analyzed with whole-exome sequencing. We identified GDAP1 variants from 10 patients clinically diagnosed with Charcot-Marie-Tooth disease (CMT)...
February 28, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28236277/dual-drainage-using-a-percutaneous-pancreatic-duct-technique-contributed-to-resolution-of-severe-acute-pancreatitis
#12
Tatsunori Satoh, Masataka Kikuyama, Yoshihiro Yokoi, Shinya Kawaguchi
A 66-year-old man was admitted for severe acute alcoholic pancreatitis with infected pancreatic necrosis (IPN). Abdominal computed tomography revealed an inflamed pancreatic head, a dilated main pancreatic duct (MPD), and a large cavity with heterogeneous fluid containing gas adjacent to the pancreatic head, and extending to the pelvis. The cavity was drained percutaneously near the pancreatic head on admission; another tube was inserted into the pelvic cavity on hospital day 3. The drained fluid contained pus with high amylase concentration...
April 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28224890/phosphorylation-of-chitosan-hema-interpenetrating-polymer-network-prepared-by-%C3%AE-radiation-for-metal-ions-removal-from-aqueous-solutions
#13
Ahmed M Elbarbary, Mohamed Mohamady Ghobashy
Interpenetrating polymer network (IPN) hydrogels, based on chitosan (CS) and 2-hydroxyethyl methacrylate (HEMA), have been prepared by γ-radiation followed by chemical modification via phosphorylation reaction and used for adsorption of Ca(II), Cu(II) and Zn(II) ions from their aqueous solutions. The gel content (%) increases with increasing the HEMA concentration. The maximum swelling (%) observed at the ratio (70/30) (CS/HEMA). CS/pHEMA IPN showed a higher thermal stability than CS. The phosphorylated hydrogel, Phos-(CS/pHEMA), characterized by XRD, EDS, SEM, DSC and TGA techniques...
April 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28220261/does-a-foot-drop-implant-improve-kinetic-and-kinematic-parameters-in-the-foot-and-ankle
#14
Kiriakos Daniilidis, Eike Jakubowitz, Anna Thomann, Sarah Ettinger, Christina Stukenborg-Colsman, Daiwei Yao
INTRODUCTION: Unlike the drop foot therapy with ortheses, the therapeutic effect of an implantable peroneus nerve stimulator (iPNS) is not well described. IPNS is a dynamic therapy option which is placed directly to the motoric part of the peroneal nerve and evokes a dorsiflexion of the paralysed foot. This retrospective study evaluates the kinematics and kinetics in drop foot patients who were treated with an iPNS. MATERIALS AND METHODS: 18 subjects (mean age 51...
April 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28213160/molecular-pathogenesis-of-peripheral-neuropathies-insights-from-drosophila-models
#15
REVIEW
Julia Bussmann, Erik Storkebaum
Peripheral neuropathies are characterized by degeneration of peripheral motor, sensory and/or autonomic axons, leading to progressive distal muscle weakness, sensory deficits and/or autonomic dysfunction. Acquired peripheral neuropathies, e.g., as a side effect of chemotherapy, are distinguished from inherited peripheral neuropathies (IPNs). Drosophila models for chemotherapy-induced peripheral neuropathy and several IPNs have provided novel insight into the molecular mechanisms underlying axonal degeneration...
February 14, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28205028/the-outcomes-of-initial-endoscopic-transluminal-drainage-are-superior-to-percutaneous-drainage-for-patients-with-infected-pancreatic-necrosis-a-prospective-cohort-study
#16
Wen-Hua He, Yong Zhu, Yin Zhu, Pi Liu, Hao Zeng, Liang Xia, Chen Yu, Hai-Ming Chen, Xu Shu, Zhi-Jian Liu, You-Xiang Chen, Nong-Hua Lu
BACKGROUND AND STUDY AIM: The commonly used minimally invasive methods for patients with infected pancreatic necrosis (IPN) are initial endoscopic transluminal drainage (ETD) and percutaneous catheter drainage (PCD), which are followed, if necessary, by endoscopic or surgical necrosectomy. This study intends to explore which of the two minimally invasive treatments leads to a better prognosis. PATIENTS AND METHODS: Patients with IPN and an indication for intervention were prospectively enrolled and underwent either initial ETD or PCD followed, if necessary, by endoscopic or surgical necrosectomy...
February 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28202949/clinical-diversity-caused-by-novel-ighmbp2-variants
#17
Jun-Hui Yuan, Akihiro Hashiguchi, Akiko Yoshimura, Hiroshi Yaguchi, Koji Tsuzaki, Azusa Ikeda, Kenji Wada-Isoe, Masahiro Ando, Tomonori Nakamura, Yujiro Higuchi, Yu Hiramatsu, Yuji Okamoto, Hiroshi Takashima
Immunoglobulin helicase μ-binding protein 2 (IGHMBP2) gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). From June 2014 to December 2015, we collected 408 cases, who referred to our genetic laboratory for genetic analysis, suspected with CMT disease or other inherited peripheral neuropathies (IPNs) on the basis of clinical manifestations and electrophysiological studies. Mutation screening was performed using Ion AmpliSeq Custom Panels, which comprise 72 disease-causing or candidate genes of IPNs...
February 16, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28198591/interpenetrating-conducting-hydrogel-materials-for-neural-interfacing-electrodes
#18
Josef Goding, Aaron Gilmour, Penny Martens, Laura Poole-Warren, Rylie Green
Conducting hydrogels (CHs) are an emerging technology in the field of medical electrodes and brain-machine interfaces. The greatest challenge to the fabrication of CH electrodes is the hybridization of dissimilar polymers (conductive polymer and hydrogel) to ensure the formation of interpenetrating polymer networks (IPN) required to achieve both soft and electroactive materials. A new hydrogel system is developed that enables tailored placement of covalently immobilized dopant groups within the hydrogel matrix...
February 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28193160/analysis-of-risk-factors-related-to-gastrointestinal-fistula-in-patients-with-severe-acute-pancreatitis-a-retrospective-study-of-344-cases-in-a-single-chinese-center
#19
Zhipeng Hua, Yongjie Su, Xuefeng Huang, Kang Zhang, Zhengyu Yin, Xiaoming Wang, Pingguo Liu
BACKGROUND: Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk of GIF in patient with SAP. This study was aimed to investigate risk factors related to GIF in the development of SAP. METHODS: The clinical data of 344 patients with SAP from 2011 to 2016 were reviewed retrospectively. All patients were divided into the GIF group and the non-GIF group, and their data analyzed with respect to 15 parameters were applied to explore potential risk factors for GIF in patients with SAP...
February 14, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28182730/68ga-dotatate-pet-ct-imaging-of-indeterminate-pulmonary-nodules-and-lung-cancer
#20
Ronald Walker, Stephen Deppen, Gary Smith, Chanjuan Shi, Jonathan Lehman, Jeff Clanton, Brandon Moore, Rena Burns, Eric L Grogan, Pierre P Massion
PURPOSE: 18F-FDG PET/CT is widely used to evaluate indeterminate pulmonary nodules (IPNs). False positive results occur, especially from active granulomatous nodules. A PET-based imaging agent with superior specificity to 18F-FDG for IPNs, is badly needed, especially in areas of endemic granulomatous nodules. Somatostatin receptors (SSTR) are expressed in many malignant cells including small cell and non-small cell lung cancers (NSCLCs). 68Ga-DOTATATE, a positron emitter labeled somatostatin analog, combined with PET/CT imaging, may improve the diagnosis of IPNs over 18F-FDG by reducing false positives...
2017: PloS One
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