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Kazumasa Oura, Tadayoshi Kato, Hideki Ohba, Yasuo Terayama
BACKGROUND: Several studies have shown a linkage between intraplaque neovascularization (IPN) and plaque instability. Although contrast-enhanced ultrasonography (CEUS) may help visualize IPN in the carotid artery, its benefits are limited in Japan, where there is no health insurance coverage for contrast agents in medical imaging. Superb microvascular imaging (SMI), however, enables the depiction of low-velocity blood flow. The current study compares the diagnostic accuracy of SMI and CEUS in the evaluation of IPN...
May 10, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Nicole Zoratto, Pietro Matricardi
Semi-interpenetrating polymer networks (semi-IPNs) and interpenetrating polymeric networks (IPNs) have emerged as innovative materials for biomedical and pharmaceutical applications. The interest in these structures is due to the possibility of combining the favorable properties of each polymeric component of the IPNs or semi-IPNs leading to a new system with properties that often differ from those of the two single components. In this respect, polysaccharides represent an opportunity in this field, combining a general biocompatibility and a good availability...
2018: Advances in Experimental Medicine and Biology
Syang-Peng Rwei, Huynh Nguyen Anh Tuan, Whe-Yi Chiang, Tun-Fun Way
A series of semi-interpenetrating polymer network (semi-IPN) hydrogels were synthesized and investigated in this study. Linear copolymer poly( N -isopropylacrylamide-co-itaconamic acid) p(NIPAM-co-IAM), which is formed by copolymerization of N -isopropylacrylamide (NIPAM) and itaconamic acid (IAM, 4-amino-2-ethylene-4-oxobutanoic acid), was introduced into a solution of NIPAM to form a series of pH and thermo dual-responsive p(NIPAM-co-IAM)/pNIPAM semi-IPN hydrogels by free radical polymerization. The structural, morphological, chemical, and physical properties of the linear copolymer and semi-IPN hydrogels were investigated...
April 28, 2018: Materials
Mansi Upadhyay, Sandeep Kumar Reddy Adena, Harsh Vardhan, Sarita K Yadav, Brahmeshwar Mishra
The research aims the development and optimization of capecitabine loaded interpenetrating polymeric network by ionotropic gelation method using polymers locust bean gum and sodium alginate by QbD approach. FMEA was performed to recognize the risks influencing CQAs. BBD was applied to study the effect of factors (polymer ratio, amount of cross-linker and curing time) on responses (particle size, % drug entrapment and % drug release). Polynomial equations and 3-D graphs were plotted to relate between factors and responses...
April 27, 2018: International Journal of Biological Macromolecules
Kay Palchak, Shubhada K Chothe, Aswathy Sebastian, Ruth H Nissly, Rhiannon Barry, Istvan Albert, Bhushan M Jayarao, Suresh V Kuchipudi
Infectious pancreatic necrosis (IPN) is an acute contagious systemic disease affecting several fish species and a critical disease in the salmonid fish farming industry. Here, we report the complete genome sequence of IPN virus (IPNV) RNA segments A and B, isolated from a farmed brook trout in Pennsylvania.
April 26, 2018: Genome Announcements
Hong Zhou, Ariella Shikanov
Various toxicants, such as drugs and their metabolites, can cause potential ovarian toxicity. As the functional units of the ovary, ovarian follicles are susceptible to this type of damage at all developmental stages. Studying the effects of toxicants on ovarian follicles is an important task. Three-dimensional (3D) hydrogels, such as fibrin alginate interpenetrating networks (FA-IPNs), can support ovarian follicle culture in vitro for extended periods of time and serve as a suitable tool for studying ovotoxicity...
2018: Methods in Molecular Biology
Sandra Pérez Álvarez, Amaury Méndez Guerrero, Bernardo Nayar Débora Duarte, Marco Antonio Magallanes Tapia, Jesús Alicia Chávez Medina, Yoannis Domínguez Rodríguez
Metarhizium rileyi (Farlow) Samson is an important entomopathogenic fungus of more than 30 species of Lepidoptera larvae. The aim of this research was to characterize isolate of M. rileyi from Quivicán, Cuba on the basis of morphological and molecular approaches. The fungus was isolated from samples of S . frugiperda larvae collected from maize fields of Quivicán municipality, Mayabeque province, Cuba, and it was cultured on PDA + Ampicillin solid media for morphological characterization. The DNA was isolated using CTAB method and internal transcribed spacer (ITS1, ITS4) were used as the primers for the amplification...
June 2018: Indian Journal of Microbiology
Ali Olad, Mahyar Pourkhiyabi, Hamed Gharekhani, Fatemeh Doustdar
Semi-interpenetrating polymer network (semi-IPN) superabsorbent nanocomposite based on montmorillonite (MMT) and sodium alginate (NaAlg)-g-poly(acrylic acid(AA))/polyvinylpyrrolidone (PVP) was synthesized. Chemical structure and surface morphology of the hydrogels were characterized by FTIR, XRD, thermogravimetric analysis (TGA), SEM, and TEM techniques. FTIR results revealed that graft polymerization, PVP interpenetration through hydrogel network, and nanocomposite formation have occurred. The coarse surface of the hydrogels was changed into interlinked porous structures in the presence of MMT...
June 15, 2018: Carbohydrate Polymers
Anthony N Cutrupi, Megan H Brewer, Garth A Nicholson, Marina L Kennerson
Inherited peripheral neuropathies (IPNs) are a clinically and genetically heterogeneous group of diseases affecting the motor and sensory peripheral nerves. IPNs have benefited from gene discovery and genetic diagnosis using next-generation sequencing with over 80 causative genes available for testing. Despite this success, up to 50% of cases remain genetically unsolved. In the absence of protein coding mutations, noncoding DNA or structural variation (SV) mutations are a possible explanation. The most common IPN, Charcot-Marie-Tooth neuropathy type 1A (CMT1A), is caused by a 1...
March 23, 2018: Molecular Genetics & Genomic Medicine
Jody L Clements, Daranee Tantbirojn, Antheunis Versluis, David R Cagna
STATEMENT OF PROBLEM: Denture tooth fracture may limit the longevity of dental prostheses. Whether the strength of the denture tooth material is affected by the denture processing technique is unclear. PURPOSE: The purpose of this in vitro study was to investigate whether the denture processing technique affects the mechanical properties of denture tooth materials. MATERIAL AND METHODS: Two denture processing techniques, injection and compression molding, were tested for 3 types of denture teeth: nanohybrid composite (NHC), interpenetrating network (IPN), and microfiller-reinforced polyacrylic (MRP)...
March 15, 2018: Journal of Prosthetic Dentistry
Loredana Elena Nita, Aurica P Chiriac, Alina Gabriela Rusu, Maria Bercea, Alina Diaconu, Nita Tudorachi
The interpenetrating polymer networks (IPNs) are promising materials due to their unique properties. In this context, in the present study, new IPN structures based on poly(dimethylaminoethyl methacrylate) (PDMAEMA) and poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5] undecane) (PITAU) were synthesized. The double network was prepared by synthesizing and crosslinking (with N, N'-methylenebis(acrylamide)) PDMAEMA in the presence of a preformed PITAU network. The effect of the two components upon some properties such us: viscoelasticity, thermal stability and swelling behavior of the new prepared gels were deeply investigated...
June 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Yizhi Zhuo, Verner Håkonsen, Zhiwei He, Senbo Xiao, Jianying He, Zhiliang Zhang
Ice accretion presents a severe risk for human safety. Although great efforts have been made for developing icephobic surfaces (the surface with an ice adhesion strength below 100 kPa), expanding the lifetime of state-of-the-art icephobic surfaces still remains a critical unsolved issue. Herein, a novel icephobic material is designed by integrating an interpenetrating polymer network (IPN) into an autonomous self-healing elastomer, which is applied in anti-icing for enhancing the mechanical durability. The molecular structure, surface morphology, mechanical properties, and durable icephobicity of the material were studied...
April 11, 2018: ACS Applied Materials & Interfaces
Lan Ma, Peiyi Wu
Well-defined poly(N-isopropylacrylamide)/poly(tributylhexylphosphonium 3-sulfopropylmethacrylate) (PNIPAM/P[P4,4,4,6 ][MC3S]) interpenetrating polymer network (IPN) microgels were synthesized by two-step precipitation polymerization, and the thermally induced phase transition mechanism of IPN microgels was investigated using dynamic light scattering (DLS), temperature-dependent IR spectroscopy together with the perturbation correlation moving window (PCMW) technique and two dimensional correlation spectroscopy (2Dcos)...
March 28, 2018: Physical Chemistry Chemical Physics: PCCP
Yuliana Rosas Hernández, Luz Arcelia García Serrano, Daniel Tapia Maruri, Antonio Ruperto Jiménez Aparicio, Brenda Hildeliza Camacho Díaz, Martha Lucía Arenas Ocampo
The main objective of this work was to optimize the process of fractionation of the bagasse of Agave angustifolia Haw, applying organosolv assisted with microwaves. The DCC was used to evaluate the effect of independent variables such as ethanol concentration (40, 50, and 60%) and reaction time (1, 1.5, and 2 h) on yield, cellulose and lignin percentages. Lignocellulosic fractions (F1 and F2) were obtained by means of organosolv assisted with microwave in an open system (atmospheric pressure) and a closed system (controlled pressure)...
April 4, 2018: Journal of Agricultural and Food Chemistry
Haixiao Wan, Jianxiang Shen, Naishen Gao, Jun Liu, Yangyang Gao, Liqun Zhang
Designing a multiple-network structure at the molecular level to tailor the mechanical properties of polymeric materials is of great scientific and technological importance. Through the coarse-grained molecular dynamics simulation, we successfully construct an interpenetrating polymer network (IPN) composed of a flexible polymer network and a stiff polymer network. First, we find that there is an optimal chain stiffness for a single network (SN) to achieve the best stress-strain behavior. Then we turn to study the mechanical behaviors of IPNs...
March 28, 2018: Soft Matter
Kaijuan Chen, Xiao Kuang, Vincent Li, Guozheng Kang, H Jerry Qi
3D printing of epoxy-based shape memory polymers with high mechanical strength, excellent thermal stability and chemical resistance is highly desirable for practical applications. However, thermally cured epoxy in general is difficult to print directly. There have been limited numbers of successes in printing epoxy but they suffer from relatively poor mechanical properties. Here, we present an ultraviolet (UV)-assisted 3D printing of thermally cured epoxy composites with high tensile toughness via a two-stage curing approach...
March 7, 2018: Soft Matter
Sahar Sultan, Aji P Mathew
3-Dimensional (3D) printing provides a unique methodology for the customization of biomedical scaffolds with respect to size, shape, pore structure and pore orientation useful for tissue repair and regeneration. 3D printing was used to fabricate fully bio-based porous scaffolds of a double crosslinked interpenetrating polymer network (IPN) from a hydrogel ink of sodium alginate and gelatin (SA/G) reinforced with cellulose nanocrystals (CNCs). CNCs provided favorable rheological properties required for 3D printing...
March 1, 2018: Nanoscale
Surinder Singh Rana, Rajesh Gupta, Mandeep Kang, Vishal Sharma, Ravi Sharma, Ujjwal Gorsi, Deepak K Bhasin
Background and Objectives: Infected pancreatic necrosis (IPN) in the early phase is treated with "step up approach" involving initial percutaneous catheter drainage (PCD) followed by necrosectomy. There is a paucity of data on a combined approach of initial PCD followed by endoscopic drainage and necrosectomy. A retrospectively study on safety and efficacy of initial PCD followed by endoscopic transluminal drainage and necrosectomy in IPN. Methods: Retrospective analysis of data of 23 patients with IPN who were treated with a combined approach...
January 2018: Endoscopic Ultrasound
Kholoud Arafa, Rehab N Shamma, Omaima N El-Gazayerly, Ibrahim M El-Sherbiny
PURPOSE: Metformin hydrochloride (MF) repurposing as adjuvant anticancer therapy for colorectal cancer (CRC) proved effective. Several studies attempted to develop MF-loaded nanoparticles (NPs), however the entrapment efficiency (EE%) was poor. Thus, the present study aimed at the facile development of a new series of chitosan (CS)-based semi-interpenetrating network (semi-IPN) NPs incorporating Pluronic® nanomicelles as nanocarriers for enhanced entrapment and sustained release of MF for efficient treatment of CRC...
July 2018: Drug Development and Industrial Pharmacy
Se Yeon Song, Min Soo Park, Jung Woo Lee, Ji Sun Yun
Silane coupling agents (SCAs) with different organofunctional groups were coated on the surfaces of Al₂O₃ ceramic particles through hydrolysis and condensation reactions, and the SCA-coated Al₂O₃ ceramic particles were dispersed in a commercial photopolymer based on interpenetrating networks (IPNs). The organofunctional groups that have high radical reactivity and are more effective in UV curing systems are usually functional groups based on acryl, such as acryloxy groups, methacrloxy groups, and acrylamide groups, and these silane coupling agents seem to improve interfacial adhesion and dispersion stability...
February 7, 2018: Nanomaterials
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