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https://www.readbyqxmd.com/read/28903873/validation-of-a-model-for-ranking-aquaculture-facilities-for-risk-based-disease-surveillance
#1
Nicolas Diserens, Laura Cristina Falzon, Beat von Siebenthal, Gertraud Schüpbach-Regula, Thomas Wahli
A semi-quantitative model for risk ranking of aquaculture facilities in Switzerland with regard to the introduction and spread of Viral Haemorrhagic Septicaemia (VHS) and Infectious Haematopoietic Necrosis (IHN) was developed in a previous study (Diserens et al., 2013). The objective of the present study was to validate this model using data collected during field visits on aquaculture sites in four Swiss cantons compared to data collected through a questionnaire in the previous study. A discrepancy between the values obtained with the two different methods was found in 32...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28888548/a-novel-approach-for-the-morphology-controlled-synthesis-of-rod-shaped-nano-hydroxyapatite-using-semi-ipn-and-ipn-as-a-template
#2
Preeti Mehta, Balbir Singh Kaith
Present work offers use of semi-interpenetrating network (semi-IPN) and interpenetrating network (IPN) as the template for the synthesis of nano-hydroxyapatites. Semi-IPN and IPN of agar-gelatin were prepared and successfully used to synthesize nano-hydroxyapatite. Graft copolymerization technique was used to alter the properties of the hybrid backbone using ammonium persulphate as an initiator and N,N'methylene-bisacrylamide (MBA) as a crosslinker. The first step was to synthesize cross-linked semi-IPN of agar-gelatin blend which was converted to a cross-linked interpenetrating polymer...
September 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28887976/nanoclay-cross-linked-semi-ipn-silk-sericin-poly-nipam-lmsh-nanocomposite-hydrogel-an-outstanding-antibacterial-wound-dressing
#3
Chaochao Yang, Rui Xue, Qingsong Zhang, Shulin Yang, Pengfei Liu, Li Chen, Ke Wang, Xiaoyong Zhang, Yen Wei
High antibacterial and skin-like hydrogels have always been the perfect wound dressing for human to protect wound from infection. Here, based on silk sericin, we design a series of nanoclay lithium magnesium silicate hydrate (LMSH) cross-linked semi-IPN sericin/poly(NIPAm/LMSH) (HSP) nanocomposite hydrogels and demonstrate advantages in serving as antibacterial wound dressing in comparison with gauze. Firstly, the effect of mass ratios of sericin/(sericin+NIPAm) upon pore structure, feasibility of mechanics and gas permeability of HSP nanocomposite hydrogels were evaluated...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28866188/interpenetrating-network-hydrogels-with-high-strength-and-transparency-for-potential-use-as-external-dressings
#4
Jingjing Wang, Jun Wei
Interpenetrating polymer network (IPN) hydrogels composed of gelatin and hydroxypropyl cellulose (HPC) were prepared by successive enzymatic and chemical crosslinking approaches. The hydrogels displayed porous structure and the pore size decreased with the increase of HPC content. Due to the entanglement and interpenetrating between the two crosslinked networks, the IPN hydrogels exhibited excellent mechanical strength and light transmittance. The maximum tensile and tear strengths of the IPN hydrogels reached 3...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865116/power-input-effects-on-degeneration-in-prolonged-penicillin-chemostat-cultures-a-systems-analysis-at-flux-residual-glucose-metabolite-and-transcript-levels
#5
Guan Wang, Baofeng Wu, Junfei Zhao, Cees Haringa, Jianye Xia, Ju Chu, Yingping Zhuang, Siliang Zhang, Joseph J Heijnen, Walter van Gulik, Amit T Deshmukh, Henk J Noorman
In the present work, by performing chemostat experiments at 400 and 600 RPM, two typical power inputs representative of industrial penicillin fermentation (P/V, 1.00 kW/m(3) in more remote zones and 3.83 kW/m(3) in the vicinity of the impellers, respectively) were scaled-down to bench-scale bioreactors. It was found that at 400 RPM applied in prolonged glucose-limited chemostat cultures, the previously reported degeneration of penicillin production using an industrial Penicillium chrysogenum strain was virtually absent...
September 2, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28862158/facile-modification-of-electrospun-fibrous-structures-with-antifouling-zwitterionic-hydrogels
#6
Tong Xu, Jing Yang, Jiamin Zhang, Yingnan Zhu, Qingsi Li, Chao Pan, Lei Zhang
Electrospinning technology can easily produce different shaped fibrous structures, making them highly valuable to various biomedical applications. However, surface contamination of biomolecules, cells, or blood has emerged as a significant challenge to the success of electrospun devices, especially artificial blood vessels, catheters and wound dressings etc. Many efforts have been made to resist the surface non-specific biomolecules or cells adsorption, but most of them require complex pre-treatment processes, hard-to-remove metal catalysts or rigorous reaction conditions...
September 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28821135/exploring-pullulan-poly-vinyl-alcohol-interpenetrating-network-microspheres-as-controlled-release-drug-delivery-device
#7
Saundray Raj Soni, Animesh Ghosh
In the present study, interpenetrating polymeric network (IPN) microsphere was prepared using glutaraldehyde assisted water-in-oil emulsion crosslinking method for controlled delivery of pirfenidone, the only chemical entity approved by US FDA for the treatment of Idiopathic Pulmonary Fibrosis (IPF). In our study, the natural biopolymer pullulan was harnessed in combination with synthetic polymer PVA for drug delivery applications. The prepared microspheres were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, solid state (13)C nuclear magnetic resonance and field emission scanning electron microscopy...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821056/fabrication-of-salecan-poly-amps-co-hmaa-semi-ipn-hydrogels-for-cell-adhesion
#8
Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Wei Dong, Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and has excellent physicochemical and biological properties. A series of hydrogels were fabricated from Salecan and poly(2-acrylamido-2-methylpropanesulfonic acid-co-N-hydroxymethyl acrylamide) (poly(AMPS-co-HMAA), PAH) by semi-IPN technique. The introduction of Salecan into the PAH network endows the system with enhanced cell adhesion properties. These semi-IPN hydrogels with open interconnected pores had pH and salt-sensitive swelling behavior. The increase in the content of hydrophilic Salecan could enhance the water uptake of the hydrogels...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28816441/an-integrated-design-material-and-fabrication-platform-for-engineering-biomechanically-and-biologically-functional-soft-tissues
#9
Onur Bas, Davide D'Angella, Jeremy G Baldwin, Nathan J Castro, Felix M Wunner, Navid T Saidy, Stefan Kollmannsberger, Alessandro Reali, Ernst Rank, Elena M De-Juan-Pardo, Dietmar W Hutmacher
We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3...
August 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28797809/the-role-of-titanium-dioxide-on-the-morphology-microstructure-and-bioactivity-of-grafted-cellulose-hydroxyapatite-nanocomposites-for-a-potential-application-in-bone-repair
#10
Saeed Saber-Samandari, Hamed Yekta, Sara Ahmadi, Kadhim Alamara
Fabrication and characterization of a novel 3D nanocomposite scaffold have been reported in this research. The purpose of developing this new 3D nanocomposite scaffolds is introducing an alternative treatment for bone tissue replacement. Outcomes confirmed that the morphology, microstructure and mechanical properties of synthesized 3D nanocomposite scaffolds closely mimics the properties of real bone tissue. The 3D nanocomposite scaffolds compose of nanoparticle hydroxyapatite which is embedded in the semi-IPN of polyacrylamide-grafted cellulose by free radical polymerization...
August 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28791703/the-medial-habenula-and-interpeduncular-nucleus-circuitry-is-critical-in-addiction-anxiety-and-mood-regulation
#11
REVIEW
Ian McLaughlin, John A Dani, Mariella De Biasi
Abstinence from chronic use of addictive drugs triggers an aversive withdrawal syndrome that compels relapse and deters abstinence. Many features of this syndrome are common across multiple drugs, involving both affective and physical symptoms. Some of the network signaling underlying withdrawal symptoms overlaps with activity that is associated with aversive mood states, including anxiety and depression. Given these shared features, it is not surprising that a particular circuit, the dorsal diencephalic conduction system, and the medial habenula (MHb) and interpeduncular nucleus (IPN), in particular, have been identified as critical to the emergence of aversive states that arise both as a result and, independently, of drug addiction...
August 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28768196/a-cooperative-mechanism-involving-ca-2-permeable-ampa-receptors-and-retrograde-activation-of-gabab-receptors-in-interpeduncular-nucleus-plasticity
#12
Peter Koppensteiner, Riccardo Melani, Ipe Ninan
The medial habenula-interpeduncular nucleus (MHb-IPN) pathway, which connects the limbic forebrain to the midbrain, has recently been implicated in aversive behaviors. The MHb-IPN circuit is characterized by a unique topographical organization, an excitatory role of GABA, and a prominent co-release of neurotransmitters and neuropeptides. However, little is known about synaptic plasticity in this pathway. An application of a high-frequency stimulation resulted in a long-lasting potentiation of glutamate release in IPN neurons...
August 1, 2017: Cell Reports
https://www.readbyqxmd.com/read/28746189/early-prediction-of-infected-pancreatic-necrosis-secondary-to-necrotizing-pancreatitis
#13
Hong-Ze Chen, Liang Ji, Le Li, Gang Wang, Xue-Wei Bai, Chun-Dong Cheng, Bei Sun
To assess the association between the clinical parameters within 48 hours of admission and the occurrence of infected pancreatic necrosis (IPN) during the late phase of necrotizing pancreatitis (NP).All patients were divided into 2 groups, the IPN and non-IPN groups. The clinical data were retrospectively analyzed. Univariate and multivariate logistic regression analyses were performed to evaluate the relationship between clinical parameters and IPN secondary to NP. The performance of each independent variable was plotted by the receiver-operating characteristic (ROC) curve...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28726576/recent-developments-in-thiolated-polymeric-hydrogels-for-tissue-engineering-applications
#14
Mani Gajendiran, Jae-Sung Rhee, Kyobum Kim
This review focuses on the recent strategy in the preparation of thiolated polymers and fabrication of their hydrogel matrices. The mechanism involved in the synthesis of thiolated polymers and fabrication of thiolated polymer hydrogels is exemplified with suitable schematic representations reported in the recent literature. The 2-iminothiolane namely "Traut's reagent" has been widely employed for effectively thiolating the natural polymers such as collagen and gelatin which contain free amino group in their back bone...
July 20, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28719186/elastomer-reinforced-with-regenerated-chitin-from-alkaline-urea-aqueous-system
#15
Peng Yu, Hui He, Yuanfang Luo, Demin Jia, Alain Dufresne
Novel hybrid elastomer/regenerated chitin (R-chitin) composites were developed, for the first time, by introducing chitin solution (dissolved in alkaline/urea aqueous solution at low temperature) into rubber latex, and then cocoagulating using ethanol as the cocoagulant. During the rapid coprecipitation process, the chitin solution showed rapid coagulant-induced gelation and a porous chitin phase was generated, and the rubber latex particles were synchronously demulsificated to form the rubbery phase. The two phases interlaced and interpenetrated simultaneously to form an interpenetrating polymer network (IPN) structure, which was evidenced by SEM observation...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718925/a-historical-review-of-the-key-bacterial-and-viral-pathogens-of-scottish-wild-fish
#16
REVIEW
I S Wallace, P McKay, A G Murray
Thousands of Scottish wild fish were screened for pathogens by Marine Scotland Science. A systematic review of published and unpublished data on six key pathogens (Renibacterium salmoninarum, Aeromonas salmonicida, IPNV, ISAV, SAV and VHSV) found in Scottish wild and farmed fish was undertaken. Despite many reported cases in farmed fish, there was a limited number of positive samples from Scottish wild fish, however, there was evidence for interactions between wild and farmed fish. A slightly elevated IPNV prevalence was reported in wild marine fish caught close to Atlantic salmon, Salmo salar L...
July 18, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28714952/a-circuit-based-mechanism-underlying-familiarity-signaling-and-the-preference-for-novelty
#17
Susanna Molas, Rubing Zhao-Shea, Liwang Liu, Steven R DeGroot, Paul D Gardner, Andrew R Tapper
Novelty preference (NP) is an evolutionarily conserved, essential survival mechanism often dysregulated in neuropsychiatric disorders. NP is mediated by a motivational dopamine signal that increases in response to novel stimuli, thereby driving exploration. However, the mechanism by which once-novel stimuli transition to familiar stimuli is unknown. Here we describe a neuroanatomical substrate for familiarity signaling, the interpeduncular nucleus (IPN) of the midbrain, which is activated as novel stimuli become familiar with multiple exposures...
September 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28712566/left-habenular-activity-attenuates-fear-responses-in-larval-zebrafish
#18
Erik R Duboué, Elim Hong, Kiara C Eldred, Marnie E Halpern
Fear responses are defensive states that ensure survival of an organism in the presence of a threat. Perception of an aversive cue causes changes in behavior and physiology, such as freezing and elevated cortisol, followed by a return to the baseline state when the threat is evaded [1]. Neural systems that elicit fear behaviors include the amygdala, hippocampus, and medial prefrontal cortex. However, aside from a few examples, little is known about brain regions that promote recovery from an aversive event [2]...
July 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28708278/whole-exome-sequencing-is-a-valuable-diagnostic-tool-for-inherited-peripheral-neuropathies-outcomes-from-a-cohort-of-50-families
#19
Taila Hartley, Justin D Wagner, Jodi Warman-Chardon, Martine Tétreault, Lauren Brady, Steven Baker, Mark Tarnopolsky, Pierre R Bourque, Jillian S Parboosingh, Christopher Smith, Brenda McInnes, A Micheil Innes, Francois Bernier, Cynthia J Curry, Grace Yoon, Gabriella A Horvath, Eric Bareke, Jacek Majewski, Dennis E Bulman, David A Dyment, Kym M Boycott
The inherited peripheral neuropathies (IPNs) are characterized by marked clinical and genetic heterogeneity and include relatively frequent presentations such as Charcot-Marie-Tooth disease and hereditary motor neuropathy, as well as more rare conditions where peripheral neuropathy is associated with additional features. There are over 250 genes known to cause IPN-related disorders but it is estimated that in ~50% of affected individuals a molecular diagnosis is not achieved. In this study, we examine the diagnostic utility of whole-exome sequencing (WES) in a cohort of 50 families with one or more affected individuals with a molecularly undiagnosed IPN with or without additional features...
July 14, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28703303/terminally-truncated-isopenicillin-n-synthase-generates-a-dithioester-product-evidence-for-a-thioaldehyde-intermediate-during-catalysis-and-a-new-mode-of-reaction-for-non-heme-iron-oxidases
#20
Luke A McNeill, Toby J N Brown, Malkit Sami, Ian J Clifton, Nicolai I Burzlaff, Timothy D W Claridge, Robert M Adlington, Jack E Baldwin, Peter J Rutledge, Christopher J Schofield
Isopenicillin N synthase (IPNS) catalyses the four-electron oxidation of a tripeptide, l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine (ACV), to give isopenicillin N (IPN), the first-formed β-lactam in penicillin and cephalosporin biosynthesis. IPNS catalysis is dependent upon an iron(II) cofactor and oxygen as a co-substrate. In the absence of substrate, the carbonyl oxygen of the side-chain amide of the penultimate residue, Gln330, co-ordinates to the active-site metal iron. Substrate binding ablates the interaction between Gln330 and the metal, triggering rearrangement of seven C-terminal residues, which move to take up a conformation that extends the final α-helix and encloses ACV in the active site...
July 12, 2017: Chemistry: a European Journal
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