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https://www.readbyqxmd.com/read/28205028/the-outcomes-of-initial-endoscopic-transluminal-drainage-are-superior-to-percutaneous-drainage-for-patients-with-infected-pancreatic-necrosis-a-prospective-cohort-study
#1
Wen-Hua He, Yong Zhu, Yin Zhu, Pi Liu, Hao Zeng, Liang Xia, Chen Yu, Hai-Ming Chen, Xu Shu, Zhi-Jian Liu, You-Xiang Chen, Nong-Hua Lu
BACKGROUND AND STUDY AIM: The commonly used minimally invasive methods for patients with infected pancreatic necrosis (IPN) are initial endoscopic transluminal drainage (ETD) and percutaneous catheter drainage (PCD), which are followed, if necessary, by endoscopic or surgical necrosectomy. This study intends to explore which of the two minimally invasive treatments leads to a better prognosis. PATIENTS AND METHODS: Patients with IPN and an indication for intervention were prospectively enrolled and underwent either initial ETD or PCD followed, if necessary, by endoscopic or surgical necrosectomy...
February 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28202949/clinical-diversity-caused-by-novel-ighmbp2-variants
#2
Jun-Hui Yuan, Akihiro Hashiguchi, Akiko Yoshimura, Hiroshi Yaguchi, Koji Tsuzaki, Azusa Ikeda, Kenji Wada-Isoe, Masahiro Ando, Tomonori Nakamura, Yujiro Higuchi, Yu Hiramatsu, Yuji Okamoto, Hiroshi Takashima
Immunoglobulin helicase μ-binding protein 2 (IGHMBP2) gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). From June 2014 to December 2015, we collected 408 cases, who referred to our genetic laboratory for genetic analysis, suspected with CMT disease or other inherited peripheral neuropathies (IPNs) on the basis of clinical manifestations and electrophysiological studies. Mutation screening was performed using Ion AmpliSeq Custom Panels, which comprise 72 disease-causing or candidate genes of IPNs...
February 16, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28198591/interpenetrating-conducting-hydrogel-materials-for-neural-interfacing-electrodes
#3
Josef Goding, Aaron Gilmour, Penny Martens, Laura Poole-Warren, Rylie Green
Conducting hydrogels (CHs) are an emerging technology in the field of medical electrodes and brain-machine interfaces. The greatest challenge to the fabrication of CH electrodes is the hybridization of dissimilar polymers (conductive polymer and hydrogel) to ensure the formation of interpenetrating polymer networks (IPN) required to achieve both soft and electroactive materials. A new hydrogel system is developed that enables tailored placement of covalently immobilized dopant groups within the hydrogel matrix...
February 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28193160/analysis-of-risk-factors-related-to-gastrointestinal-fistula-in-patients-with-severe-acute-pancreatitis-a-retrospective-study-of-344-cases-in-a-single-chinese-center
#4
Zhipeng Hua, Yongjie Su, Xuefeng Huang, Kang Zhang, Zhengyu Yin, Xiaoming Wang, Pingguo Liu
BACKGROUND: Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk of GIF in patient with SAP. This study was aimed to investigate risk factors related to GIF in the development of SAP. METHODS: The clinical data of 344 patients with SAP from 2011 to 2016 were reviewed retrospectively. All patients were divided into the GIF group and the non-GIF group, and their data analyzed with respect to 15 parameters were applied to explore potential risk factors for GIF in patients with SAP...
February 14, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28182730/68ga-dotatate-pet-ct-imaging-of-indeterminate-pulmonary-nodules-and-lung-cancer
#5
Ronald Walker, Stephen Deppen, Gary Smith, Chanjuan Shi, Jonathan Lehman, Jeff Clanton, Brandon Moore, Rena Burns, Eric L Grogan, Pierre P Massion
PURPOSE: 18F-FDG PET/CT is widely used to evaluate indeterminate pulmonary nodules (IPNs). False positive results occur, especially from active granulomatous nodules. A PET-based imaging agent with superior specificity to 18F-FDG for IPNs, is badly needed, especially in areas of endemic granulomatous nodules. Somatostatin receptors (SSTR) are expressed in many malignant cells including small cell and non-small cell lung cancers (NSCLCs). 68Ga-DOTATATE, a positron emitter labeled somatostatin analog, combined with PET/CT imaging, may improve the diagnosis of IPNs over 18F-FDG by reducing false positives...
2017: PloS One
https://www.readbyqxmd.com/read/28174589/effects-of-insect-proof-net-cultivation-rice-duck-farming-and-organic-matter-return-on-rice-dry-matter-accumulation-and-nitrogen-utilization
#6
Xin Liu, Guochun Xu, Qiangsheng Wang, Yuhao Hang
Insect-proof net cultivation (IPN), rice-duck farming (RD), and organic matter return (OM) are important methods to realize sustainable development of rice production. A split-plot field experiment was performed to study the effects of IPN, RD, and OM on the rice yield, dry matter accumulation and N utilization. Results showed that compared to inorganic N fertilizer (IN), wheat straw return, and biogas residue return increased the rice yield by 2.11-4.28 and 4.78-7.67%, respectively, and also improved dry matter and N accumulation after the elongation stage (EG), dry matter and N translocation, and N recovery efficiency (NRE)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28128773/hip-and-knee-effects-after-implantation-of-a-drop-foot-stimulator
#7
Daiwei Yao, Matthias Lahner, Eike Jakubowitz, Anna Thomann, Sarah Ettinger, Yvonne Noll, Christina Stukenborg-Colsman, Kiriakos Daniilidis
BACKGROUND: An active ankle dorsiflexion is essential for a proper gait pattern. If there is a failure of the foot lifting, considerable impairments occur. The therapeutic effect of an implantable peroneus nerve stimulator (iPNS) for the ankle dorsiflexion is already approved by recent studies. However, possible affection for knee and hip motion after implantation of an iPNS is not well described. OBJECTIVE: The objective of this retrospective study was to examine with a patient cohort whether the use of iPNS induces a lower-extremity flexion withdrawal response in the form of an increased knee and hip flexion during swing phase...
January 20, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28094067/differential-intensity-projection-for-visualisation-and-quantification-of-plaque-neovascularisation-in-contrast-enhanced-ultrasound-images-of-carotid-arteries
#8
Wing Keung Cheung, Benoy N Shah, Antonio Stanziola, Dorothy M Gujral, Navtej S Chahal, David O Cosgrove, Roxy Senior, Meng-Xing Tang
Studies have reported that intraplaque neovascularisation (IPN) is closely correlated with plaque vulnerability. In this study, a new image processing approach, differential intensity projection (DIP), was developed to visualise and quantify IPN in contrast-enhanced non-linear ultrasound image sequences of carotid arteries. DIP used the difference between the local temporal maximum and the local temporal average signals to identify bubbles against tissue non-linear artefact and noise. The total absolute and relative areas occupied by bubbles within each plaque were calculated to quantify IPN...
January 13, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28049087/sequestration-of-dyes-from-artificially-prepared-textile-effluent-using-rsm-ccd-optimized-hybrid-backbone-based-adsorbent-kinetic-and-equilibrium-studies
#9
Sukriti, Jitender Sharma, Amritpal Singh Chadha, Vaishali Pruthi, Prerna Anand, Jaspreet Bhatia, B S Kaith
Present work reports the synthesis of semi-Interpenetrating Network Polymer (semi-IPN) using Gelatin-Gum xanthan hybrid backbone and polyvinyl alcohol in presence of l-tartaric acid and ammonium persulphate as the crosslinker-initiator system. Reaction parameters were optimized with Response Surface Methodology (RSM) in order to maximize the percent gel fraction of the synthesized sample. Polyvinyl alcohol, l-Tartaric acid, ammonium persulphate, reaction temperature, time and pH of the reaction medium were found to make an impact on the percentage gel fraction obtained...
April 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28044410/preparation-of-a-salecan-poly-2-acrylamido-2-methylpropanosulfonic-acid-co-2-methacryloxy-ethyl-trimethylammonium-chloride-semi-ipn-hydrogel-for-drug-delivery
#10
Xiaoliang Qi, Junjian Li, Wei Wei, Ting Su, Gancheng Zuo, Xihao Pan, Jianfa Zhang, Wei Dong
Salecan is a water-soluble bacterial polysaccharide consisting of glucopyranosyl units linked by α-1,3 and β-1,3 glycosidic bonds. salecan is suitable for the development of hydrogels for biomedical applications, given its outstanding physicochemical and biological profiles. In this study we designed a new semi-interpenetrating polymer network hydrogel that introduces the salecan polysaccharide into a stimuli-responsive poly(2-acrylamido-2-methylpropanosulfonic acid-co-[2-(methacryloxy)ethyl]trimethylammonium chloride) (PAM) hydrogel matrix for controlled insulin release...
January 3, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28041916/preparation-and-characterization-of-oxidized-starch-poly-n-n-dimethylaminoethyl-methacrylate-semi-ipn-cryogels-and-in-vitro-controlled-release-evaluation-of-indomethacin
#11
Diana Felicia Apopei Loghin, Gabriela Biliuta, Sergiu Coseri, Ecaterina Stela Dragan
Fabrication of novel semi-interpenetrating polymer network (semi-IPN) cryogels by cross-linking polymerization of N,N-dimethylaminoethyl methacrylate (DMAEM) in the presence of either oxidized potato starch (OPS) or oxidized wheat starch (OWS) and their characterization are presented in the paper. The influence of the nature of entrapped polymer on the properties of the composite cryogels was evaluated by the swelling kinetics, FT-IR spectroscopy, scanning electron microscopy, and response at external stimuli such as temperature, pH, and ionic strength...
December 29, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28026935/thermoresponsive-semi-ipn-hydrogel-microfibers-from-continuous-fluidic-processing-with-high-elasticity-and-fast-actuation
#12
Yan Liu, Kaihuan Zhang, Jinghong Ma, G Julius Vancso
Hydrogels with rapid and strong response to external stimuli and possessing high elasticity and strength have been considered as platform materials for numerous applications, e.g., in biomaterials engineering. Thermoresponsive hydrogels based on semi-interpenetrating polymer networks (semi-IPN) featuring N-isopropylacrylamide with copolymers of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) p(NIPAM-HEMA) chains are prepared and described. The copolymer was characterized by FTIR, NMR, and GPC. The semi-IPN structured hydrogel and its responsive properties were evaluated by dynamic mechanical measurements, SEM, DSC, equilibrium swelling ratio, and dynamic deswelling tests...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28025812/the-anatomy-and-physiology-of-eyeblink-classical-conditioning
#13
Kaori Takehara-Nishiuchi
This chapter reviews the past research toward identifying the brain circuit and its computation underlying the associative memory in eyeblink classical conditioning. In the standard delay eyeblink conditioning paradigm, the conditioned stimulus (CS) and eyeblink-eliciting unconditioned stimulus (US) converge in the cerebellar cortex and interpositus nucleus (IPN) through the pontine nuclei and inferior olivary nucleus. Repeated pairings of CS and US modify synaptic weights in the cerebellar cortex and IPN, enabling IPN neurons to activate the red nucleus and generate the conditioned response (CR)...
December 27, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28012776/a-novel-in-feed-delivery-platform-applied-for-oral-dna-vaccination-against-ipnv-enables-high-protection-in-atlantic-salmon-salmon-salar
#14
Miguel Reyes, Cesar Ramírez, Ivan Ñancucheo, Ricardo Villegas, Guillermo Schaffeld, Luis Kiman, Javier Gonzalez, Patricio Oyarzun
BACKGROUND: DNA vaccination has emerged as a promising tool against infectious diseases of farmed fish. Oral delivery allows stress-free administration that is ideal for mass immunization and of paramount importance for infectious pancreatic necrosis (IPN) and other viral disease that affect young salmonids and cause economic losses in aquaculture worldwide. METHODS: We describe the development and in vivo assessment of an "in-feed" formulation strategy for oral immunization with liposomal DNA vaccines, by delivering a vaccine construct coding for an immunogenic region of the VP2 capsid protein...
December 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27960330/reshaping-lithium-plating-stripping-behavior-via-bifunctional-polymer-electrolyte-for-room-temperature-solid-li-metal-batteries
#15
Xian-Xiang Zeng, Ya-Xia Yin, Nian-Wu Li, Wen-Cheng Du, Yu-Guo Guo, Li-Jun Wan
High-energy rechargeable Li metal batteries are hindered by dendrite growth due to the use of a liquid electrolyte. Solid polymer electrolytes, as promising candidates to solve the above issue, are expected to own high Li ion conductivity without sacrificing mechanical strength, which is still a big challenge to realize. In this study, a bifunctional solid polymer electrolyte exactly having these two merits is proposed with an interpenetrating network of poly(ether-acrylate) (ipn-PEA) and realized via photopolymerization of ion-conductive poly(ethylene oxide) and branched acrylate...
December 14, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27933324/effect-of-aqueous-storage-on-original-and-repair-bond-strength-and-residual-monomer-release-of-fiberreinforced-composites
#16
Diana Wolff, Michael Coupek, Ralf Erber, Tanja Krueger, Johannes Krisam, Hans Joerg Staehle, Cornelia Frese
PURPOSE: To evaluate the effects of aqueous storage on shear bond strength (SBS) and monomer release of fiberreinforced composites (FRCs). MATERIALS AND METHODS: Four unidirectional FRCs were tested, including one semi-interpenetrating polymer network (IPN) (ES, everStick) and three cross-linked polymer (CLP) FRCs (GT, GrandTec; TF, TenderFiber; DP, Dentapreg). The SBS of samples of original resin to fresh FRC with an intact oxygen inhibition layer (n = 30/group) and repair resin to FRC after surface treatment (n = 30/group) was evaluated after 6 and 12 months of storage in artificial saliva...
2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27931029/selective-necrosectomy-for-infected-pancreatic-necrosis
#17
Ola Ahmed, Claire L Donohoe, Daragh B Murphy, Brian J Marsh, John Conneely, Gerry P McEntee
BACKGROUND: Until recently, a diagnosis of infected pancreatic necrosis (IPN) warranted necrosectomy, which was associated with high morbidity and mortality rates greater than 20%. Preoperative percutaneous drainage delayed the need for necrosectomy with improved outcomes. METHODS: In 2008, this institution changed its approach to the management of such cases opting instead for percutaneous drainage with selective deferred necrosectomy. A total of 38 consecutive patients with IPN from January 2008 to December 2014 were included...
December 9, 2016: Digestive Surgery
https://www.readbyqxmd.com/read/27890353/anxiety-and-nicotine-dependence-emerging-role-of-the-habenulo-interpeduncular-axis
#18
REVIEW
Susanna Molas, Steven R DeGroot, Rubing Zhao-Shea, Andrew R Tapper
While innovative modern neuroscience approaches have aided in discerning brain circuitry underlying negative emotional behaviors including fear and anxiety responses, how these circuits are recruited in normal and pathological conditions remains poorly understood. Recently, genetic tools that selectively manipulate single neuronal populations have uncovered an understudied circuit, the medial habenula (mHb)-interpeduncular (IPN) axis, that modulates basal negative emotional responses. Interestingly, the mHb-IPN pathway also represents an essential circuit that signals heightened anxiety induced by nicotine withdrawal...
February 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27865957/starch-functionalized-biodegradable-semi-ipn-as-a-ph-tunable-controlled-release-platform-for-memantine
#19
Sayan Ganguly, Tushar Maity, Subhadip Mondal, Poushali Das, Narayan C Das
Sequentially prepared semi-interpenetrating polymer network (semi-IPN) has been developed here via Michael type addition of acrylic acid (AA) and 2-acrylamido-2-methylpropane sulfonic acid (AMPS) on to starch. The semi-IPN hydrogel have proficiency in fast water imbibition towards gel network and swelling tunable character with pH alteration in ambient condition. The synthesized gel has been characterized by Fourier transformed infrared spectroscopy (FTIR) to confirm Michael type grafting of monomers on to starch...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27858313/complete-genomic-sequence-of-an-infectious-pancreatic-necrosis-virus-isolated-from-rainbow-trout-oncorhynchus-mykiss-in-china
#20
Feng Ji, Jing-Zhuang Zhao, Miao Liu, Tong-Yan Lu, Hong-Bai Liu, Jiasheng Yin, Li-Ming Xu
Infectious pancreatic necrosis (IPN) is a significant disease of farmed salmonids resulting in direct economic losses due to high mortality in China. However, no gene sequence of any Chinese infectious pancreatic necrosis virus (IPNV) isolates was available. In the study, moribund rainbow trout fry samples were collected during an outbreak of IPN in Yunnan province of southwest China in 2013. An IPNV was isolated and tentatively named ChRtm213. We determined the full genome sequence of the IPNV ChRtm213 and compared it with previously identified IPNV sequences worldwide...
November 18, 2016: Virus Genes
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