Read by QxMD icon Read


Leise Riber, Mette Burmølle, Martin Alm, Stefan M Milani, Peter Thomsen, Lars H Hansen, Søren J Sørensen
The spread of antimicrobial resistance, usually mediated by horizontal transfer of plasmids, limits the options of treating bacterial infections and thereby poses a crucial human health problem. The disturbance of plasmid stability within bacterial species in clinical environments serves as a novel strategy to reduce the development and dissemination of antibiotic resistance. We tested the ability of irgasan to destabilize plasmids from Escherichia coli K-12 cells when added directly into liquid growth medium at concentrations below levels of marked bacterial growth inhibition, or when released into liquid growth medium from irgasan-impregnated Interpenetrating Polymer Network (IPN) silicone hydrogel objects, a novel technology developed as drug-delivery platform...
October 12, 2016: Plasmid
Robert A Moran, Niloofar Y Jalaly, Ayesha Kamal, Sandesh Rao, Robert Klapheke, Theodore W James, Swetha Kambhampati, Martin A Makary, Kenzo Hirose, Vivek Kumbhari, Ellen M Stein, Mouen A Khashab, Anne Marie Lennon, Anthony N Kalloo, Atif Zaheer, Ruben Hernaez, Vikesh K Singh
BACKGROUND & OBJECTIVES: Infected pancreatic necrosis (IPN) is associated with increased morbidity and mortality. Gut barrier dysfunction has been shown to increase the risk of bacterial translocation from the gut into the pancreatic bed. The primary aim of the study is to evaluate if ileus, a clinical marker of gut barrier dysfunction, can predict the development of IPN. METHODS: A retrospective cohort study of patients with necrotizing pancreatitis (NP) was conducted from 2000 to 2014...
October 3, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Narges Naseri, Deepa Bhanumathyamma, Aji P Mathew, Kristiina Oksman, Lenart Girandon
Double crosslinked interpenetrating polymer network (IPN) hydrogels of sodium alginate and gelatin (SA/G) reinforced with 50 wt% cellulose nanocrystals (CNC) have been prepared via freeze-drying process. The IPNs were designed to incorporate CNC with carboxyl surface groups as a part of the network contribute to the structural integrity and mechanical stability of the hydrogel. Structural morphology studies of the hydrogels showed a 3-dimensional (3D) network of interconnected pores with diameters in the range of 10-192 μm and hierarchical pores with a nanostructured pore wall roughness, which has potential benefits for cell adhesion...
October 11, 2016: Biomacromolecules
Jimin Shim, Ji Su Lee, Jin Hong Lee, Hee Joong Kim, Jong-Chan Lee
Gel polymer electrolytes (GPEs) based on semi-interpenetrating polymer network (IPN) structure for lithium-ion batteries were prepared by mixing boron-containing crosslinker (BC) composed of ion-conducting ethylene oxide (EO) chains, crosslinkable methacrylate group, and anion-trapping boron moiety with poly(vinylidene fluoride) (PVDF) followed by ultraviolet light-induced curing process. Various physical and electrochemical properties of the GPEs were systematically investigated by varying the EO chain length and boron content...
October 4, 2016: ACS Applied Materials & Interfaces
R McCarthy, R Segurado, M Crealey, A Twomey
Parenteral Nutrition may be prescribed as a standard PN (SPN) formulation or as an individualised PN (IPN) formulation. SPN may have advantages in terms of rapid availability, less prescription errors, decreased risk of infection and cost savings but IPN, specifically tailored to an infants needs, may achieve better outcomes in terms of nutrient intake and weight gain. The aim of our study was to determine if VLBW infants in our NICU benefited from receiving IPN over currently available SPN solutions. Our findings were that VLBW infants prescribed IPN received significantly more amino acid (28%), glucose (6%), energy (11%) and calcium (8%) from the aqueous phase of PN than had they received a similar volume of SPN...
2016: Irish Medical Journal
Julien Morin, Yuri Bedjanian
Kinetics and products of the thermal decomposition of isopropyl nitrate (IPN, C3H7NO3) have been studied using a low pressure flow reactor combined with a quadrupole mass spectrometer. The rate constant of IPN decomposition was measured as a function of pressure (1-12.5 Torr of helium) and temperature in the range 473-658 K using two methods: from kinetics of nitrate loss and those of reaction product (CH3 radical) formation. The fit of the observed falloff curves with two parameter expression [Formula: see text] provided the following low and high pressure limits for the rate constant of IPN decomposition: k0 = 6...
October 6, 2016: Journal of Physical Chemistry. A
Q Wan, R C Masters, D Lidzey, K J Abrams, M Dapor, R A Plenderleith, S Rimmer, F Claeyssens, C Rodenburg
Recently developed detectors can deliver high resolution and high contrast images of nanostructured carbon based materials in low voltage scanning electron microscopes (LVSEM) with beam deceleration. Monte Carlo Simulations are also used to predict under which exact imaging conditions purely compositional contrast can be obtained and optimised. This allows the prediction of the electron signal intensity in angle selective conditions for back-scattered electron (BSE) imaging in LVSEM and compares it to experimental signals...
September 15, 2016: Ultramicroscopy
Michael Stenger, Kasper Klein, Rasmus B Grønnemose, Janne K Klitgaard, Hans J Kolmos, Jes S Lindholt, Martin Alm, Peter Thomsen, Thomas E Andersen
Approximately half of all nosocomial bloodstream infections are caused by bacterial colonization of vascular catheters. Attempts have been made to improve devices using anti-adhesive or antimicrobial coatings; however, it is often difficult to bind coatings stably to catheter materials, and the low amounts of drug in thin-film coatings limit effective long-term release. Interpenetrating polymer networks (IPNs) are polymer hybrid materials with unique drug release properties. While IPNs have been extensively investigated for use in tablet- or capsule-based drug delivery systems, the potential for use of IPNs in drug release medical devices remains largely unexplored...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Stephen Mutoloki, Trude B Jøssund, Gordon Ritchie, Hetron M Munang'andu, Øystein Evensen
Infectious pancreatic necrosis virus (IPNV) is the causative agent of IPN, an important disease of salmonids. IPNV infections result in either sub-clinical or overt disease and the basis of this difference is not well-understood. The objective of the present study was to determine the VP2 gene of the virus associated with the different forms of clinical manifestation. Groups of Atlantic salmon (Salmo salar L.) reared in farms located in different IPN disease pressures were monitored from brood stock until grow-out over a 3 year period...
2016: Frontiers in Microbiology
Sougata Jana, Abhisek Banerjee, Kalyan Kumar Sen, Sabyasachi Maiti
In this study, gelatin and carboxymethyl tamarind gum (CTG) were chemically cross-linked to control the delivery of aceclofenac from their interpenetrating network (IPNs). Infrared spectra, thermal and X-ray data supported that drug and polymer was compatible in the composite hydrogels. Irregularly shaped IPN microstructures were seen under field emission scanning electron microscope (FE-SEM). IPN system was capable of entrapping about 96% of the drug fed. CTG in IPN structures suppressed the drug release rate in HCl solution (pH1...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
A Michael Rajesh, Kiritkumar Mangaldas Popat
OBJECTIVE: The objective was to evaluate taste masking of azithromycin (AZI) by ion exchange resins (IERs) and the formation of covalent semi interpenetrating polymer network (IPN) beads using chitosan (CS) and sodium carboxylated agarose (SCAG) for sustained release of drug. METHODS: Methacrylic acid (MAA)-based IERs were prepared by suspension polymerization method. Drug release complexes (DRCs) were prepared by different drug:resin ratios i.e. 1:1, 1:2 and 1:4...
September 7, 2016: Drug Development and Industrial Pharmacy
Sunil Shenvi, Rajesh Gupta, Mandeep Kang, Madhu Khullar, Surinder Singh Rana, Rajinder Singh, Deepak Kumar Bhasin
BACKGROUND: The timing of surgery in patients not responding to percutaneous catheter drainage (PCD) in infected pancreatic necrosis remains challenging. MATERIALS AND METHODS: A randomized controlled trial was designed to establish the optimal timings of surgery following PCD in patients with infected pancreatic necrosis (IPN). Patients who did not improve by day 10 after PCD insertion were included in the present study and were randomized to group A (step-up approach as a bridge to surgery) or group B (step-up approach with intention to avoid surgery)...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
A Chrostek, P Grygiel, M Anczewska, J Wciórka, P Świtaj
OBJECTIVE: Loneliness is an established risk factor for numerous negative health outcomes. The aims of the present study were to compare the levels of loneliness between patients with psychotic disorders and members of the general population and to identify factors independently associated with loneliness in psychosis. METHODS: A total of 207 patients with psychotic disorders recruited between February 2013 and February 2015 from inpatient and day wards and an outpatient clinic of the Institute of Psychiatry and Neurology (IPN) in Warsaw (Poland) were included in this cross-sectional study...
October 2016: Comprehensive Psychiatry
Petra Laššuthová, Dana Šafka Brožková, Marcela Krůtová, Jana Neupauerová, Jana Haberlová, Radim Mazanec, Pavel Dřímal, Pavel Seeman
BACKGROUND: Inherited peripheral neuropathies (IPN) are the most common inherited neurological condition. It represents a highly heterogeneous group, both clinically and genetically. Targeted disease specific gene panel massively parallel sequencing (MPS) seems to be a useful tool in diagnosis of disorders with high genetic heterogeneity. METHODS: In our study, we have designed, validated and updated our own custom gene panel of all known genes associated with IPN...
2016: Orphanet Journal of Rare Diseases
Branden L Eggan, Sarah E McCallum
The medial habenula-interpeduncular nucleus (MHb-IPN) pathway has recently been shown to modulate multiple effects nicotine in vivo, however it remains unclear which receptor subtypes in this pathway are critical for mediating these responses. To identify MHb and IPN receptors that play a role in nicotine reward, we studied receptors prevalent in these nuclei, including nicotinic acetylcholine receptors (nAChRs) and the receptor for substance P (neuokinin-1; NK1 receptor) using a model of behavioral and neurochemical sensitization to nicotine...
January 1, 2017: Behavioural Brain Research
Wejih Dougaz, Ibtissem Bouasker, Samia Ben Osman, Ramzi Nouira, Chadli Dziri
BACKGROUND: The traditional approach to the drainage of infected pancreatic necrosis (IPN) is open necrosectomy. As an alternative to open necrosectomy, percutaneous drainage is the first-line treatment of IPN. This study is aimed to identify predictive factor of failure after CT-guided percutaneous catheter drainage (PCD) of IPN. METHODS: Between June 1st 1988 and October 31th 2011, 26 patients with IPN were treated by PCD. The outcome measures were the failure of the PCD and/or death...
January 2016: La Tunisie Médicale
Ine Van Nieuwenhove, Achim Salamon, Kirsten Peters, Geert-Jan Graulus, José C Martins, Daniel Frankel, Ken Kersemans, Filip De Vos, Sandra Van Vlierberghe, Peter Dubruel
The present work aims at constructing the ideal scaffold matrix of which the physico-chemical properties can be altered according to the targeted tissue regeneration application. Ideally, this scaffold should resemble the natural extracellular matrix (ECM) as close as possible both in terms of chemical composition and mechanical properties. Therefore, hydrogel films were developed consisting of methacrylamide-modified gelatin and starch-pentenoate building blocks because the ECM can be considered as a crosslinked hydrogel network consisting of both polysaccharides and structural, signaling and cell-adhesive proteins...
November 5, 2016: Carbohydrate Polymers
Liang Ji, Jia-Chen Lv, Zeng-Fu Song, Mai-Tao Jiang, Le Li, Bei Sun
BACKGROUND: Severe acute pancreatitis (SAP) remains a clinical challenge with considerable morbidity and mortality. An early identification of infected pancreatic necrosis (IPN), a life-threatening evolution secondary to SAP, is obliged for a more preferable prognosis. Thus, the present study was conducted to identify the risk factors of IPN secondary to SAP. METHODS: The clinical data of patients with SAP were retrospectively analyzed. Univariate and multivariate logistic regression analyses were sequentially performed to assess the associations between the variables and the development of IPN secondary to SAP...
August 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Katherine Bootsma, Martha M Fitzgerald, Brandon Free, Elizabeth Dimbath, Joe Conjerti, Greg Reese, Dominik Konkolewicz, Jason A Berberich, Jessica L Sparks
Interpenetrating network (IPN) hydrogel materials are recognized for their unique mechanical properties. While IPN elasticity and toughness properties have been explored in previous studies, the factors that impact the time-dependent stress relaxation behavior of IPN materials are not well understood. Time-dependent (i.e. viscoelastic) mechanical behavior is a critical design parameter in the development of materials for a variety of applications, such as medical simulation devices, flexible substrate materials, cellular mechanobiology substrates, or regenerative medicine applications...
July 22, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Stuti S Rajgarhia, Sadhan C Jana, George G Chase
Polymer nanofibers with interpenetrating network (IPN) morphology are used in this work for the development of composite, hydrophobic filter media in conjunction with glass fibers for removal of water droplets from ultralow sulfur diesel (ULSD). The nanofibers are produced from hydrophobic polyvinyl acetate (PVAc) and hydrophilic polyvinylpyrrolidone (PVP) by spinning the polymer solutions using gas jet fiber (GJF) method. The nanofibers coat the individual glass fibers due to polar-polar interactions during the spinning process and render the filter media highly hydrophobic with a water contact angle approaching 150°...
August 24, 2016: ACS Applied Materials & Interfaces
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"