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IPN and unstable plaque

Héctor De León, Stéphanie Boué, Walter K Schlage, Natalia Boukharov, Jurjen W Westra, Stephan Gebel, Aaron VanHooser, Marja Talikka, R Brett Fields, Emilija Veljkovic, Michael J Peck, Carole Mathis, Vy Hoang, Carine Poussin, Renee Deehan, Katrin Stolle, Julia Hoeng, Manuel C Peitsch
BACKGROUND: Numerous inflammation-related pathways have been shown to play important roles in atherogenesis. Rapid and efficient assessment of the relative influence of each of those pathways is a challenge in the era of "omics" data generation. The aim of the present work was to develop a network model of inflammation-related molecular pathways underlying vascular disease to assess the degree of translatability of preclinical molecular data to the human clinical setting. METHODS: We constructed and evaluated the Vascular Inflammatory Processes Network (V-IPN), a model representing a collection of vascular processes modulated by inflammatory stimuli that lead to the development of atherosclerosis...
2014: Journal of Translational Medicine
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