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https://www.readbyqxmd.com/read/28274217/disruption-of-rcsb-by-a-duplicated-sequence-in-a-curli-producing-escherichia-coli-o157-h7-results-in-differential-gene-expression-in-relation-to-biofilm-formation-stress-responses-and-metabolism
#1
V K Sharma, D O Bayles, D P Alt, T Looft, B W Brunelle, J A Stasko
BACKGROUND: Escherichia coli O157:H7 (O157) strain 86-24, linked to a 1986 disease outbreak, displays curli- and biofilm-negative phenotypes that are correlated with the lack of Congo red (CR) binding and formation of white colonies (CR(-)) on a CR-containing medium. However, on a CR medium this strain produces red isolates (CR(+)) capable of producing curli fimbriae and biofilms. RESULTS: To identify genes controlling differential expression of curli fimbriae and biofilm formation, the RNA-Seq profile of a CR(+) isolate was compared to the CR(-) parental isolate...
March 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28258869/comparative-skin-evaluation-after-split-thickness-skin%C3%A2-grafts-using-2-different-acellular-dermal-matrices%C3%A2-to-cover-composite-forearm-defects
#2
Myung Chul Lee, Yong Jun Jang, In Sik Yun, Dae Hyun Lew, Won Jai Lee
PURPOSE: The combination of acellular dermal matrix (ADM) and split-thickness skin graft (STSG) has been widely adopted to overcome functional and cosmetic limitations of conventional STSG. In this study, we evaluated the efficacy of this combination using 2 types of ADM: cadaveric acellular dermal matrix (CDM) and bovine acellular dermal matrix (BDM). METHODS: We recruited 72 patients undergoing autologous STSG to cover radial forearm free flap donor sites. They were included in 1 of 3 therapeutic groups: group 1, STSG using CDM (n = 29); group 2, STSG using BDM (n = 20); and group 3, STSG only (n = 23)...
February 28, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28211615/targeting-of-crosstalk-between-tumor-and-tumor-microenvironment-by-%C3%AE-d-mannuronic-acid-m2000-in-murine-breast-cancer-model
#3
Fatemeh Hosseini, Hadi Hassannia, Ahmad Mahdian-Shakib, Farhad Jadidi-Niaragh, Seyed Ehsan Enderami, Mohammadjavad Fattahi, Ali Anissian, Abbas Mirshafiey, Parviz Kokhaei
Metastasis is the main cause of death in breast cancer patients. Inflammatory processes following crosstalk between tumor cells and tumor microenvironment play an important role in progression and metastasis of cancer. Hence, targeting of these interactions may represent a novel promising strategy for breast cancer therapy. So, we investigated the effects of β-D mannuronic acid (BDM), a new antiinflammatory agent, on 4T1 breast cancer cell line both in vitro and in vivo. Proliferation assays revealed low-cytotoxic effect of BDM on 4T1 cells...
March 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28159937/unidimensional-measurement-may-be-superior-to-assess-primary-tumor-response-after-neoadjuvant-chemotherapy-for-nasopharyngeal-carcinoma
#4
Chuanben Chen, Xiurong Lin, Yuanji Xu, Penggang Bai, Youping Xiao, Yuhui Pan, Chao Li, Zhizhong Lin, Mingwei Zhang, Yunbin Chen
Application of current response evaluation criteria in solid tumors (RECIST 1.1) for assessment of irregularly shaped nasopharyngeal carcinoma (NPC) is a gray area with much ambiguity. Our aim was to compare unidimensional measurements (UDM) and bidimensional measurements (BDM) on magnetic resonance images in alternative planes for measurement of tumor response after neoadjuvant chemotherapy (NACT) in patients with locally advanced NPC. 59 patients with untreated non-metastatic NPC were prospectively enrolled...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28158184/seeking-goldilocks-during-evolution-of-drug-resistance
#5
Gavin Sherlock, Dmitri A Petrov
Speciation can occur when a population is split and the resulting subpopulations evolve independently, accumulating mutations over time that make them incompatible with one another. It is thought that such incompatible mutations, known as Bateson-Dobzhansky-Muller (BDM) incompatibilities, may arise when the two populations face different environments, which impose different selective pressures. However, a new study in PLOS Biology by Ono et al. finds that the first-step mutations selected in yeast populations evolving in parallel in the presence of the antifungal drug nystatin are frequently incompatible with one another...
February 2017: PLoS Biology
https://www.readbyqxmd.com/read/27957304/life-expectancy-and-its-socioeconomic-determinants-in-iran
#6
Somayeh Delavari, Hamed Zandian, Satar Rezaei, Mehdi Moradinazar, Sajad Delavari, Ali Saber, Razieh Fallah
INTRODUCTION: Life expectancy at birth (LEB) is closely associated with the degree of economic and social development in developed and developing countries. This study aimed to examine the socioeconomic factors affecting LEB in Iran from 1985 to 2013. METHODS: Time series analysis was used to examine the effects of key explanatory factors (GDP per capita, number of doctors per 10,000 population, degree of urbanization, food availability, CO2 emission, total fertility rate, inflation rate, and literacy rate) on LEB in Iran from 1985 to 2013...
October 2016: Electronic Physician
https://www.readbyqxmd.com/read/27928922/function-of-myosin-during-entry-and-egress-of-equid-herpesvirus-type-1-in-primary-murine-neurons
#7
J Cymerys, A Słońska, J Skwarska, M W Bańbura
Equid herpesvirus type 1 (EHV-1) is a major pathogen of horses with a worldwide distribution, which can cause various clinical signs ranging from mild respiratory disease to neurological disorders. To initiate an effective infection, EHV-1 evolved a broad spectrum of mechanisms exploiting the host cell, including its actin filaments. An actin-myosin-driven transport has been described to precede cellular entry of different viruses. Therefore, in the present study we investigated the role of actin motor protein - myosin, during replication of two EHV-1 strains: Jan-E (wild-type EHV-1 strain isolated from aborted equine fetus) and Rac-H (attenuated strain highly adapted in cell cultures in vitro) in primary murine neurons...
2016: Acta Virologica
https://www.readbyqxmd.com/read/27796576/cardiac-inotropy-lusitropy-and-ca-2-handling-with-major-metabolic-substrates-in-rat-heart
#8
Zai Hao Zhao, Jae Boum Youm, Yue Wang, Jeong Hoon Lee, Jae Hwi Sung, Joon-Chul Kim, Sun Hee Woo, Chae Hun Leem, Sung Joon Kim, Lan Cui, Yin Hua Zhang
Fatty acid (FA)-dependent oxidation is the predominant process for energy supply in normal heart. Impaired FA metabolism and metabolic insufficiency underlie the failing of the myocardium. So far, FA metabolism in normal cardiac physiology and heart failure remains undetermined. Here, we evaluate the mechanisms of FA and major metabolic substrates (termed NF) on the contraction, relaxation, and Ca(2+) handling in rat left ventricular (LV) myocytes. Our results showed that NF significantly increased myocyte contraction and facilitated relaxation...
November 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27782117/detection-of-genetic-incompatibilities-in-non-model-systems-using-simple-genetic-markers-hybrid-breakdown-in-the-haplodiploid-spider-mite-tetranychus-evansi
#9
B Knegt, T Potter, N A Pearson, Y Sato, H Staudacher, B C J Schimmel, E T Kiers, M Egas
When two related species interbreed, their hybrid offspring frequently suffer from reduced fitness. The genetics of hybrid incompatibility are described by the Bateson-Dobzhansky-Muller (BDM) model, where fitness is reduced by epistatic interactions between alleles of heterospecific origin. Unfortunately, most empirical evidence for the BDM model comes from a few well-studied model organisms, restricting our genetic understanding of hybrid incompatibilities to limited taxa. These systems are predominantly diploid and incompatibility is often complete, which complicates the detection of recessive allelic interactions and excludes the possibility to study viable or intermediate stages...
April 2017: Heredity
https://www.readbyqxmd.com/read/27548493/effects-of-balsamodendron-mukul-gum-resin-extract-on-articular-cartilage-in-papain-induced-osteoarthritis
#10
Jayanand Manjhi, Maneesh Gupta, Anvesha Sinha, Beena Rawat, Durg V Rai
Context • Osteoarthritis (OA) is one of the most prevalent chronic diseases of the musculoskeleton, causing functional disability among older adults. Management of OA includes conventional pharmacological treatments consisting primarily of nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, physiotherapy, and surgical procedures. The medications are not ideal therapeutic agents; NSAIDs in particular can cause serious side effects. Objective • The study was conducted to investigate the effects of Balsamodendron mukul (BDM) gum resin extract on cartilage damage and microstructural changes in the subchondral bone of rats with papain-induced, osteoarthritic knee joints...
July 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27514733/in-vitro-differentiation-potential-of-human-haematopoietic-cd34-cells-towards-pancreatic-%C3%AE-cells
#11
Manne Mudhu Sunitha, Lokanathan Srikanth, Pasupuleti Santhosh Kumar, Chodimella Chandrasekhar, Potukuchi Venkata Gurunadha Krishna Sarma
Haematopoietic stem cells (HSCs) possess multipotent ability to differentiate into various types of cells on providing appropriate niche. In the present study, the differentiating potential of human HSCs into β-cells of islets of langerhans was explored. Human HSCs were apheretically isolated from a donor and cultured. Phenotypic characterization of CD34 glycoprotein in the growing monolayer HSCs was confirmed by immunocytochemistry and flow cytometry techniques. HSCs were induced by selection with beta cell differentiating medium (BDM), which consists of epidermal growth factor (EGF), fibroblast growth factor (FGF), transferrin, Triiodo-l-Tyronine, nicotinamide and activin A...
October 2016: Cell Biology International
https://www.readbyqxmd.com/read/27485179/arsenate-accumulation-distribution-and-toxicity-associated-with-titanium-dioxide-nanoparticles-in-daphnia-magna
#12
Mengting Li, Zhuanxi Luo, Yameng Yan, Zhenhong Wang, Qiaoqiao Chi, Changzhou Yan, Baoshan Xing
Titanium dioxide nanoparticles (nano-TiO2) are widely used in consumer products. Nano-TiO2 dispersion could, however, interact with metals and modify their behavior and bioavailability in aquatic environments. In this study, we characterized and examined arsenate (As(V)) accumulation, distribution, and toxicity in Daphnia magna in the presence of nano-TiO2. Nano-TiO2 acts as a positive carrier, significantly facilitating D. magna's ability to uptake As(V). As nano-TiO2 concentrations increased from 2 to 20 mg-Ti/L, total As increased by a factor of 2...
September 6, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27463719/an-analysis-on-sensor-locations-of-the-human-body-for-wearable-fall-detection-devices-principles-and-practice
#13
Ahmet Turan Özdemir
Wearable devices for fall detection have received attention in academia and industry, because falls are very dangerous, especially for elderly people, and if immediate aid is not provided, it may result in death. However, some predictive devices are not easily worn by elderly people. In this work, a huge dataset, including 2520 tests, is employed to determine the best sensor placement location on the body and to reduce the number of sensor nodes for device ergonomics. During the tests, the volunteer's movements are recorded with six groups of sensors each with a triaxial (accelerometer, gyroscope and magnetometer) sensor, which is placed tightly on different parts of the body with special straps: head, chest, waist, right-wrist, right-thigh and right-ankle...
2016: Sensors
https://www.readbyqxmd.com/read/27413170/biotin-deficiency-enhances-the-inflammatory-response-of-human-dendritic-cells
#14
Sudhanshu Agrawal, Anshu Agrawal, Hamid M Said
The water-soluble biotin (vitamin B7) is indispensable for normal human health. The vitamin acts as a cofactor for five carboxylases that are critical for fatty acid, glucose, and amino acid metabolism. Biotin deficiency is associated with various diseases, and mice deficient in this vitamin display enhanced inflammation. Previous studies have shown that biotin affects the functions of adaptive immune T and NK cells, but its effect(s) on innate immune cells is not known. Because of that and because vitamins such as vitamins A and D have a profound effect on dendritic cell (DC) function, we investigated the effect of biotin levels on the functions of human monocyte-derived DCs...
September 1, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27366658/eliciting-and-measuring-betrayal-aversion-using-the-bdm-mechanism
#15
Simone Quercia
Betrayal aversion has been operationalized as the evidence that subjects demand a higher risk premium to take social risks compared to natural risks. This evidence has been first shown by Bohnet and Zeckhauser (2004) using an adaptation of the Becker - DeGroot - Marschak mechanism (BDM, Becker et al. (1964)). We compare their implementation of the BDM mechanism with a new version designed to facilitate subjects' comprehension. We find that, although the two versions produce different distributions of values, the size of betrayal aversion, measured as an average treatment difference between social and natural risk settings, is not different across the two versions...
May 2016: Journal of the Economic Science Association
https://www.readbyqxmd.com/read/27329482/directional-cerebrospinal-fluid-movement-between-brain-ventricles-in-larval-zebrafish
#16
Ryann M Fame, Jessica T Chang, Alex Hong, Nicole A Aponte-Santiago, Hazel Sive
BACKGROUND: Cerebrospinal fluid (CSF) contained within the brain ventricles contacts neuroepithelial progenitor cells during brain development. Dynamic properties of CSF movement may limit locally produced factors to specific regions of the developing brain. However, there is no study of in vivo CSF dynamics between ventricles in the embryonic brain. We address CSF movement using the zebrafish larva, during the major period of developmental neurogenesis. METHODS: CSF movement was monitored at two stages of zebrafish development: early larva [pharyngula stage; 27-30 h post-fertilization (hpf)] and late larva (hatching period; 51-54 hpf) using photoactivatable Kaede protein to calculate average maximum CSF velocity between ventricles...
June 21, 2016: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/27222176/-effect-of-2-3-butanedione-monoxime-on-calcium-paradox-induced-heart-injury-in-rats
#17
Ling-Heng Kong, Xiao-Ming Gu, Xing-Li Su, Na Sun, Ming Wei, Juan-Xia Zhu, Pan Chang, Jing-Jun Zhou
OBJECTIVE: To investigate the Effect of 2,3-butanedione monoxime (BDM) on calcium paradox-induced heart injury and its underlying mechanisms. METHODS: Thirty-two adult male SD rats were randomized into 4 groups, namely the control group, BDM treatment control group, calcium paradox group, and BDM treatment group. Isolated Sprague Dawley male rat hearts underwent Langendorff perfusion and the left ventricular pressure (LVP) and left ventricular end-diastolic pressure (LVEDP) were monitored...
May 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27174825/accumulation-and-sub-cellular-partitioning-of-metals-and-as-in-the-clam-venerupis-corrugata-different-strategies-towards-different-elements
#18
Cátia Velez, Etelvina Figueira, Amadeu M V M Soares, Rosa Freitas
The main goal of the present study was to assess accumulation, tolerance and sub-cellular partitioning of As, Hg, Cd and Pb in Venerupis corrugata. Results showed an increase of elements accumulation in V. corrugata with the increase of exposure. However, organisms presented higher capacity to accumulate Hg, Cd and Pb (BCF ≥ 12.8) than As (BCF ≤ 2.1) and higher accumulation rate for Cd and Pb than for Hg and As. With the increase of Hg exposure concentrations clams tended to increase the amount of metal bound to metal-sensitive fractions, which may explain the mortality recorded at the highest exposure concentration...
August 2016: Chemosphere
https://www.readbyqxmd.com/read/27041248/2-3-butanedione-monoxime-facilitates-successful-resuscitation-in-a-dose-dependent-fashion-in-a-pig-model-of-cardiac-arrest
#19
Byung Kook Lee, Mu Jin Kim, Kyung Woon Jeung, Sung Soo Choi, Sang Wook Park, Seong Woo Yun, Sung Min Lee, Dong Hun Lee, Yong Il Min
PURPOSE: Ischemic contracture compromises the hemodynamic effectiveness of cardiopulmonary resuscitation (CPR) and resuscitability from cardiac arrest. In a pig model of cardiac arrest, 2,3-butanedione monoxime (BDM) attenuated ischemic contracture. We investigated the effects of different doses of BDM to determine whether increasing the dose of BDM could improve the hemodynamic effectiveness of CPR further, thus ultimately improving resuscitability. METHODS: After 16minutes of untreated ventricular fibrillation and 8minutes of basic life support, 36 pigs were divided randomly into 3 groups that received 50mg/kg (low-dose group) of BDM, 100mg/kg (high-dose group) of BDM, or an equivalent volume of saline (control group) during advanced cardiovascular life support...
June 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26950627/subcellular-partitioning-kinetics-metallothionein-response-and-oxidative-damage-in-the-marine-mussel-mytilus-galloprovincialis-exposed-to-cadmium-based-quantum-dots
#20
Thiago Lopes Rocha, Tânia Gomes, Emerson Giuliani Durigon, Maria João Bebianno
The environmental health impact of metal-based nanomaterials is of emerging concern, but their metabolism and detoxification pathways in marine bioindicator species remain unclear. This study investigated the role of subcellular partitioning kinetics, metallothioneins (MTs) response and oxidative damage (lipid peroxidation - LPO) in the marine mussel Mytilus galloprovincialis exposed to CdTe quantum dots (QDs) in comparison with its dissolved counterpart. Mussels were exposed to QDs and dissolved Cd for 21 days at 10 μg Cd L(-1) followed by a 50 days depuration...
June 1, 2016: Science of the Total Environment
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