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https://www.readbyqxmd.com/read/29768474/sonographic-visualization-of-nipple-blood-flow-can-help-differentiate-paget-disease-from-benign-eczematous-nipple-lesions
#1
Hideaki Ogata, Yukio Mitsuzuka, Naoko Honma, Miho Yoshida, Makoto Sumazaki, Fumi Saito, Masahiro Kobayashi, Kazutoshi Shibuya, Tetsuo Mikami, Hironori Kaneko
PURPOSE: Paget disease of the breast is a rare cancer that originates from the nipple-areolar complex. It is often overlooked and misdiagnosed as benign chronic eczema of the nipple. We aimed to retrospectively verify whether blood flow analysis using Doppler sonography was useful for detecting the presence of Paget disease. METHODS: In this retrospective study, 12 patients with pathologically proven unilateral nipple eczematous lesions (seven with Paget disease and five with simple dermatitis) were included...
2018: PloS One
https://www.readbyqxmd.com/read/29768286/comparison-between-ultrasonography-and-galactography-in-detecting-lesions-in-patients-with-pathologic-nipple-discharge
#2
Hyun Kyung Jung, Young Mi Park, Hye Jin Baek, Hye Jung Choo, Eun-Kyung Kim, Dong Wook Kim, Sun Joo Lee, Jin Hwa Lee
PURPOSE: This study aimed to compare the diagnostic performance of breast ultrasonography (US) with that of galactography in the detection of lesions in patients with pathologic nipple discharge. METHODS: We included 46 cases from 39 patients (all women; mean age, 44.0 years; range, 22-68 years) who had pathologic nipple discharge and underwent US and galactography between March 2004 and December 2012. Two radiologists retrospectively reviewed and compared the detectability of lesions on US and galactography images...
May 15, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29767488/a-lesion-of-the-nipple-in-a-previously-mastectomized-patient
#3
Ignazio Stanganelli, Maria B De Felici Del Giudice, Laura Mazzoni, Serena Magi, Calogero Pagliarello
No abstract text is available yet for this article.
August 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29762454/correction-of-tuberous-nipple-areolar-complex-deformity-in-gynecomastia-the-deformity-that-can-get-forgotten
#4
Yvette Godwin
The desired end point of surgical reduction of gynecomastia is a masculine breast appearance and symmetry. This article concentrates on the tuberous deformity of the nipple areolar complex (NAC) that can present in gynecomastia and is sometimes overlooked at surgical correction.This deformity can be corrected at primary surgery if it is recognized preoperatively. If missed, or not adequately corrected, the postoperative result of primary reduction may be deemed incomplete by the patient and they will request revision...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29761052/asymmetries-in-mother-infant-behaviour-in-barbary-macaques-macaca-sylvanus
#5
Barbara Regaiolli, Caterina Spiezio, William Donald Hopkins
Asymmetries in the maternal behaviour and anatomy might play an important role in the development of primate manual lateralization. In particular, early life asymmetries in mother's and infant's behaviour have been suggested to be associated with the development of the hand preference of the offspring. The aim of this study was to investigate the presence of behavioural asymmetries in different behavioural categories of mother-infant dyads of zoo-living Barbary macaques ( Macaca sylvanus ). The study subjects were 14 Barbary macaques involved in seven mother-infant dyads housed in Parco Natura Viva, Italy...
2018: PeerJ
https://www.readbyqxmd.com/read/29758119/loss-of-protein-phosphatase-6-in-mouse-keratinocytes-enhances-k-ras-g12d-driven-tumor-promotion
#6
Koreyuki Kurosawa, Yui Inoue, Yoichiro Kakugawa, Yoji Yamashita, Kosuke Kanazawa, Kazuhiro Kishimoto, Miyuki Nomura, Yuki Momoi, Ikuro Sato, Natsuko Chiba, Mai Suzuki, Honami Ogoh, Hidekazu Yamada, Koh Miura, Toshio Watanabe, Nobuhiro Tanuma, Masahiro Tachi, Hiroshi Shima
Here, we address the function of protein phosphatase 6 (PP6) loss on K-ras-initiated tumorigenesis in keratinocytes. To do so, we developed tamoxifen-inducible double mutant (K-rasG12D -expressing and Ppp6c-deficient) mice in which K-rasG12D expression is driven by the cytokeratin 14 (K14) promoter. Doubly-mutant mice showed early onset tumor formation in lip, nipples, external genitalia, anus and palms, and had to be sacrificed by three weeks after induction by tamoxifen, while comparably-treated K-rasG12D -expressing mice did not...
May 14, 2018: Cancer Science
https://www.readbyqxmd.com/read/29757354/a-modified-inverted-nipple-correction-technique-that-preserves-breastfeeding
#7
Rui Feng, Weiwei Li, Bing Yu, Yudan Zhou
Background: An inverted nipple may affect the appearance of the breasts and breastfeeding, but traditional surgical procedures might injure the normal lactiferous ducts and damage sensory functions. Objectives: The aim of the study was to propose a minimally invasive and reliable method that preserves breastfeeding and corrects Grade I and II inverted nipples. Methods: This was a randomized controlled trial of 230 female patients with unilateral or bilateral inverted nipples and 30 patients with normal nipples who visited the Preconception Counseling Department of our hospital from February 2009 to January 2016...
May 11, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29753185/us-guided-diffuse-optical-tomography-clinicopathological-features-affect-total-hemoglobin-concentration-in-breast-cancer
#8
Wenxiang Zhi, Yu Wang, Cai Chang, Fen Wang, Yaling Chen, Na Hu, Xiaoli Zhu, Li Xie
PURPOSE: To investigate breast cancers total hemoglobin concentration (THC) characteristics and its association with clinical pathologic findings. MATERIALS AND METHODS: The study was approved by the institutional review board and all patients provided written informed consent. 447 breast cancer patients, totally 455 lesions were included in our study. The size and THC of breast lesions were measured by conventional ultrasound (US) and US-guided Diffuse Optical Tomography (DOT) 1-2 days before surgery...
May 9, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29747156/maternal-areola-ph-a-chemical-basis-for-mother-infant-recognition
#9
Vincenzo Zanardo, Francesca Volpe, Matteo Parotto, Lara Giliberti, Alphonse Simbi, Lorenzo Severino, Gianluca Straface
BACKGROUND: The human female's areolar region is the point of arrival of a natural progression from birth to breastfeeding continuum, supported by numerous functional features. AIMS: The aim of this study was to look more closely into the areola' skin chemical signals that are uniquely important for mother-infant chemoemission, chemoreception, and breastfeeding continuum. STUDY DESIGN: A dermatological study of the areolae and corresponding breast quadrants was undertaken on 71 healthy, at-term women...
May 7, 2018: Early Human Development
https://www.readbyqxmd.com/read/29746281/aesthetic-unit-boundary-approach-of-large-fibroadenoma-resection
#10
Chien-Wei Wang, Robyn M Hatley, Kenneth Christian Walters, Walter L Pipkin, Diane Bairas, Jack C Yu
BACKGROUND: Fibroadenomas are the most common benign breast tumors in adolescents. Surgical excision is indicated when the tumor becomes large or symptomatic. Multiple approaches have been described. However, unsightly scars, excess skin, and breast asymmetry are common challenges after tumor resection. The aims of our study were to describe a concentric circumareolar approach combining the round-block technique and geometric principles in the management of large benign breast tumors...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29746276/deepithelialized-skin-reduction-preserves-skin-and-nipple-perfusion-in-immediate-reconstruction-of-large-and-ptotic-breasts
#11
Danielle H Rochlin, Dung H Nguyen
BACKGROUND: Women with large and/or ptotic breasts are often not considered candidates for nipple-sparing mastectomy (NSM) and/or immediate breast reconstruction given difficulties avoiding ischemic complications and achieving a favorable aesthetic result. We report a novel technique involving deepithelialized skin reduction to simultaneously reduce the skin envelope and preserve perfusion to the skin and nipple in immediate breast reconstruction for women that fit this high-risk anatomic profile...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29743728/spatially-correlated-phenotyping-reveals-k5-positive-luminal-progenitor-cells-and-p63-k5-14-positive-stem-cell-like-cells-in-human-breast-epithelium
#12
Werner Boecker, Laura van Horn, Göran Stenman, Christine Stürken, Udo Schumacher, Thomas Loening, Lukas Liesenfeld, Eberhard Korsching, Doreen Gläser, Katharina Tiemann, Igor Buchwalow
Understanding the mechanisms regulating human mammary epithelium requires knowledge of the cellular constituents of this tissue. Different and partially contradictory definitions and concepts describing the cellular hierarchy of mammary epithelium have been proposed, including our studies of keratins K5 and/or K14 as markers of progenitor cells. Furthermore, we and others have suggested that the p53 homolog p63 is a marker of human breast epithelial stem cells. In this investigation, we expand our previous studies by testing whether immunohistochemical staining with monospecific anti-keratin antibodies in combination with an antibody against the stem cell marker p63 might help refine the different morphologic phenotypes in normal breast epithelium...
May 9, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29736675/influence-of-flap-thickness-on-nipple-projection-after-nipple-reconstruction-using-a-modified-star-flap
#13
Naohiro Ishii, Jiro Ando, Michiko Harao, Masaru Takemae, Kazuo Kishi
BACKGROUND: In nipple reconstruction, the width, length, and thickness of modified star flaps are concerns for long-term reconstructed nipple projection. However, the flap's projection has not been analyzed, based on its thickness. The aim of the present study was to investigate how flap thickness in a modified star flap influences the resulting reconstructed nipple and achieves an appropriate flap width in design. METHODS: Sixty-three patients who underwent nipple reconstruction using a modified star flap following implant-based breast reconstruction between August 2014 and July 2016 were included in this case-controlled study...
May 7, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29725545/single-stage-nipple-sparing-mastectomy-and-reduction-mastopexy-in-the-ptotic-breast
#14
M E Pontell, N Saad, A Brown, M Rose, R Ashinoff, A Saad
Purpose: Given the proposed increased risk of nipple-areolar complex (NAC) necrosis, nipple-sparing mastectomy (NSM) is generally not recommended for patients with large or significantly ptotic breasts. NAC preserving strategies in this subgroup include staged or simultaneous NSM and reduction mastopexy. We present a novel approach towards simultaneous NSM and reduction mastopexy in patients with large, ptotic breasts. Methods: Literature pertaining to NSM for women with large, ptotic breasts was reviewed and a surgical approach was designed to allow for simultaneous NSM and reduction mastopexy in such patients...
2018: Plastic Surgery International
https://www.readbyqxmd.com/read/29721469/practical-consensus-recommendatons-for-paget-s-disease-in-breast-cancer
#15
A Gaurav, V Gupta, R Koul, S Dabas, R Sareen, K Geeta, V Arora, Purvish M Parikh, S Aggarwal
Paget's disease of the breast is a rare type of cancer of the nipple-areola complex and that is often associated with an underlying in situ or invasive carcinoma. Diagnosis and treatment of Paget's disease is controversial. Expert oncologists discuss on the update on the approaches of Paget's disease diagnosis and its treatment options. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists...
April 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29718895/long-term-outcomes-of-patients-with-breast-cancer-after-nipple-sparing-mastectomy-skin-sparing-mastectomy-followed-by-immediate-transverse-rectus-abdominis-musculocutaneous-flap-reconstruction-comparison-with-conventional-mastectomy-in-a-single-center-study
#16
Sae Byul Lee, Jong Won Lee, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Jin Sup Eom, Taik Jong Lee, Sei-Hyun Ahn
To evaluate the oncological outcomes of patients with breast cancer after nipple-sparing mastectomy (NSM)/skin-sparing mastectomy (SSM), followed by immediate reconstruction, as compared to conventional mastectomy (CM).SSM/NSM has been increasingly used to treat women with breast cancer who wish to preserve the overlying breast skin, but concern exist regarding its oncological safety due to the potential for residual breast tissue. We report our experience performing SSM/NSM for breast cancer treatment compared to CM with a long follow-up period...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29717339/inverted-nipple-treatment-and-poliglecaprone-spacer
#17
Lidia Dessena, Sandy Dast, Simon Perez, Razvan Mercut, Christian Herlin, Raphael Sinna
INTRODUCTION: Nipple inversion is defined as a non-projectile nipple. It is a frequent pathologic condition, in which the whole nipple, or a portion of its, is buried inward towards the lactiferous duct and lies below the plane of the areola. Numerous strategies have been described to correct nipple inversion. All the procedures have the purpose to give a good shape to the nipple, preserving its function and sensitivity, when it is possible. To avoid recurrences and to obtain good aesthetic results, we present a modified percutaneous technique...
May 1, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29708089/need-for-improved-public-health-protection-of-young-people-wanting-body-piercing-evidence-from-a-look-back-exercise-at-a-piercing-and-tattooing-premises-with-poor-hygiene-practices-wales-uk-2015
#18
M Perry, H Lewis, D Rh Thomas, B Mason, G Richardson
Following a cluster of serious pseudomonas skin infections linked to a body piercing and tattooing premises, a look-back exercise was carried out to offer clients a screen for blood-borne viruses. Of those attending for screening 72% (581/809) had a piercing procedure in the premises of interest: 94 (16%) were under 16 years of age at the time of screening. The most common site of piercing was ear (34%), followed by nose (27%), nipple (21%) and navel (21%). A small number (<5) tested positive for hepatitis B and C, with no evidence this was linked to the premises...
April 30, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29703097/the-sex-life-of-women-surviving-breast-cancer
#19
Anna Ghizzani, Simone Bruni, Stefano Luisi
The diagnosis of breast cancer elicits diverse emotional responses in patients and partners. Surviving cancer has raised new needs and caretakers must understand the medical and psychological latent effects of oncology therapy. Improving patients' well-being is crucial as 19 million survivors are expected in the next decade in the United States alone. In general, sexuality contributes to one's well-being but when it is disrupted by the occurrence of cancer, women withdraw emotionally, no longer feel desirable due to esthetic damage, and become overwhelmed by the thought of sex...
April 27, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29698821/determination-of-permeation-pathways-of-hydrophilic-or-hydrophobic-dyes-through-the-mammary-papilla
#20
Samantha L Kurtz, Louise B Lawson
The transport pathways and permeation kinetics of lipophilic and hydrophilic fluorescent dyes through porcine mammary papillae were visualized and quantified. Porcine mammary papillae, removed from full-thickness abdominal tissue, were positioned in a Franz diffusion cell for passive diffusion studies. Solutions containing the fluorescent dyes were applied topically for time periods ranging from 30 minutes to 48 hours. Dye concentrations in tissue and Franz diffusion compartments were analyzed using fluorescence microscopy and fluorimetry...
April 23, 2018: International Journal of Pharmaceutics
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