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https://www.readbyqxmd.com/read/28528191/subcutaneous-implant-breast-reconstruction-time-to-reconsider
#1
REVIEW
M-K Tasoulis, F M Iqbal, S Cawthorn, F MacNeill, R Vidya
Improvements in breast surgery techniques such as skin and nipple preserving mastectomy and innovative prosthetics (implants, acellular dermal matrices and meshes) is renewing interest in subcutaneous (pre-pectoral) implant reconstruction. The aim of this paper is to review the current literature in an attempt to provide a rationale that may support a return to subcutaneous implant placement, so minimising the pain and functional problems resulting from submuscular breast reconstruction.
May 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28523890/handy-hints-about-raynaud-s-phenomenon-in-children-a-critical-review
#2
REVIEW
Donato Rigante, Michele Fastiggi, Francesco Ricci, Francesca D'Errico, Benedetta Bracci, Cristina Guerriero
Raynaud's phenomenon (RP) is a vasospastic disorder characterized by recurrent self-limited episodes of skin pallor, cyanosis, and hyperemia caused by paroxysmal spasms in the small arteries of the fingers and toes and can occur in any age group. Hands, feet, nose, ears, and nipples can be affected. The diagnosis is made clinically, assessing varying degrees of ischemia in the involved areas of skin, but this transient ischemia may also herald the onset of connective tissue disease. Investigation is recommended when RP starts in childhood to exclude an underlying autoimmune condition and close follow-up for its development...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28523888/spontaneous-brownish-nipple-discharge-in-a-9-year-old-boy
#3
Roberto Méndez-Gallart, Maria García-Palacios, Adolfo Bautista-Casasnovas
No abstract text is available yet for this article.
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28521415/bioinformatics-analysis-of-dysregulated-micrornas-in-the-nipple-discharge-of-patients-with-breast-cancer
#4
Kai Zhang, Ya-Wen Wang, Rong Ma
MicroRNAs (miRNAs/miRs) have been reported to be associated with the tumorigenesis and progression of various types of human cancer; however, the underlying mechanisms of this association remain unclear. The aim of the present study was to explore the potential functions of miRNAs in the development of breast cancer using bioinformatics analysis, based on the miRNA expression profile in nipple discharge. A previous study demonstrated the upregulation of miR-3646 and miR-4484, and the downregulation of miR-4732-5p in the nipple discharge of patients with breast cancer, compared with patients with benign breast lesions...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28515925/nipple-sparing-mastectomies-clinical-outcomes-from-a-single-academic-institution
#5
Barbara Dull, Leah Conant, Terence Myckatyn, Marissa Tenenbaum, Amy Cyr, Julie A Margenthaler
Nipple-sparing mastectomies (NSMs) are increasingly used in the surgical treatment of patients with breast cancer and for prevention of breast cancer. The present study was performed to review the outcomes of patients undergoing NSMs at a single large university setting. A retrospective chart review was performed on all patients undergoing NSMs from 2008-2014. Charts were reviewed for demographic data and patient characteristics. Tumor and breast size, cancer recurrence and complications were also evaluated...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28514220/case-242-radiation-induced-angiosarcoma
#6
Meredith Disharoon, Kamilia F Kozlowski, Jessica M Kaniowski
History In 2004, this woman received a diagnosis of invasive mammillary carcinoma, tubular variant, strongly positive for estrogen and progesterone receptors. Her lesion was found at screening mammography performed at an outside institution when she was 59 years old. She underwent partial mastectomy, with partial axillary node dissection and sentinel node mapping. A 0.6 × 0.5 cm Nottingham grade 1 infiltrating ductal carcinoma was removed from the right upper outer quadrant, margins were free of tumor, and there was no angiolymphatic invasion...
June 2017: Radiology
https://www.readbyqxmd.com/read/28508614/methods-for-rating-sexual-development-in-girls
#7
Vincenzo De Sanctis, Ihab Zaki Elhakim, Ashraf T Soliman, Heba Elsedfy, Rania Elalaily, Giuseppe Millimaggi
Sexual maturity rating (SMR) is important in population studies and in clinical care. Pubertal staging allows doctors to assess the maturation of adolescents to correlate several pubertal phenomena such as age at menarche, growth spurt and final height, to advise and manage patients appropriately and to have sensitive "sensors" of the effects of environmental exposure on human populations. The commonly used markers of the timing of female puberty are thelarche and menarche. Appearance of the breast bud is the first indicator of puberty onset in 90% of girls...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28507843/a-new-local-flap-nipple-reconstruction-technique-using-dermal-bridge-and-preoperatively-designed-tattoo
#8
Takako Komiya, Yoshiko Iwahira
BACKGROUND: Nipple-areolar reconstruction is the final step in breast reconstruction. Reconstruction using local flaps and tattooing is useful in cases of bilateral reconstruction, a small nipple-areolar complex (NAC) as the donor site, and avoiding disturbance of the normal side and other body parts. However, this method can cause projection loss and color fading of the nipple. Moreover, the breast mound is reconstructed with an implant. METHODS: We performed nipple-areolar reconstruction of 90 nipples using clover-designed flaps oriented at 120 degrees and tattooing after breast silicone implantation in 64 women...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28498546/the-use-of-inverted-l-posteromedial-thigh-l-pmt-flap-for-autologous-breast-reconstruction-a-case-report
#9
Mario F Scaglioni, Maximilian Eder, Pietro Giovanoli
The posteromedial thigh (PMT) flap has been described for breast reconstruction in vertical fashion (vPMT). However, it might not incorporate enough soft tissue for reconstruction of a medium size breast. Here, we present a case utilizing the free inverted-L posteromedial thigh (L-PMT) flap for autologous reconstruction of the breast. A 65-year-old woman with a body max index (BMI) of 24.5 kg/m(2) underwent nipple sparring mastectomy and received immediate unilateral breast reconstruction. The flap was raised based on the first medial perforator of the profunda femoris artery (PFA)...
May 12, 2017: Microsurgery
https://www.readbyqxmd.com/read/28497019/anatomical-basis-of-pedicles-in-breast-reduction
#10
REVIEW
Marcelo Irigo, Leonardo Coscarelli, Alberto Rancati
The mammary gland is composed of multiple tubules acinar pockets in which the secretory layer, connective tissue stroma, and fatty tissue all respond to hormonal and systemic influences. These structures are irrigated by three vascular pedicle branches, from the axillary artery, internal mammary artery, and intercostal artery. This vascular anastomotic arrangement forms the anatomical basis of the flaps used in breast reduction techniques. The veins form a strong subdermal network, latticed with the arterial network...
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28497017/improving-aesthetic-outcomes-in-mastopexy-with-the-autoprosthesis-technique
#11
Maurizio Nava, Alberto Rancati, Nicola Rocco, Giuseppe Catanuto, Marcelo Irigo
BACKGROUND: Many techniques have been described for mastopexy, with several types of skin incisions and parenchymal rearrangements. We present a parenchymal rearrangement technique allowing better upper pole fullness and nipple-areola-complex (NAC) projection when performing a mastopexy, with a combination of a superior pedicle for the NAC and an inferiorly-based parenchymal flap, the so-called "autoprosthesis". METHODS: From January 2008 to June 2015, 184 patients underwent "autoprosthesis" mastopexy...
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28495572/a-tumor-ultrasound-guided-incision-tugi-approach-to-nipple-sparing-mastectomy-balancing-oncologic-safety-and-technical%C3%A2-outcomes
#12
Emil J Fernando, Benjamin R Eskenazi, Risal S Djohan, Stephen R Grobmyer
BACKGROUND: Nipple-sparing mastectomy (NSM) is a prevalent operation for patients with breast cancer. Indications have been limited to tumors accessible via radial, infra-mammary, or periareolar incisions out of concern for oncologic and technical safety. We study an alternative approach to NSM based on tumor ultrasound-guided incisions (TUGI) and report its oncologic and technical outcomes. MATERIALS AND METHODS: A retrospective chart review examined patients who underwent TUGI NSM between 2013 and 2016...
April 12, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28494526/ultrasonographic-evaluation-of-women-with-pathologic-nipple-discharge
#13
Jung Hyun Yoon, Haesung Yoon, Eun-Kyung Kim, Hee Jung Moon, Youngjean Vivian Park, Min Jung Kim
Nipple discharge is a common symptom that is alarming for the patient since it can be a presenting symptom of breast cancer. Breast imaging is used to examine women with pathologic nipple discharge in order to detect any lesions that may be present and to assist in the differential diagnosis. The modalities of breast imaging include mammography, breast ultrasonography (US), and magnetic resonance imaging. Breast US is currently considered to be useful for the visualization of ductal structures and intraductal lesions that cause nipple discharge...
April 9, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28488344/nipple-aspirate-fluid-a-liquid-biopsy-for-diagnosing-breast-health
#14
Sadr-Ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Joanne Mullarkey, Wayne Burrill, Laurence H Patterson, Richard Linforth, Mohamed Salhab, Chris Sutton
PURPOSE: Nipple secretions are protein-rich and a potential source of breast cancer biomarkers for breast cancer screening. Previous studies of specific proteins have shown limited correlation with clinicopatholigical features. Our aim, in this pilot study, was to investigate the intra- and inter-patient protein composition of nipple secretions and the implications for their use as liquid biopsies. EXPERIMENTAL DESIGN: Matched pairs of NAF (n = 15) were characterised for physicochemical properties and SDS PAGE...
May 10, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28485985/breast-metastases-from-extramammary-malignancies-multimodality-imaging-aspects
#15
Almir G V Bitencourt, Roberta R M Gama, Luciana Graziano, Erika M S Negrão, Silvia M P S Sabino, Anapaula H U Watanabe, Camila S Guatelli, Juliana A Souza, Edmundo C Mauad, Elvira F Marques
Breast metastases from extramammary cancers are rare and usually related to poor prognosis. The extramammary tumors most frequently exhibiting breast metastases are melanoma, lymphomas, ovarian cancer, lung, neuroendocrine tumors, and sarcomas. Due to the lack of reliable and specific clinical or radiological signs for the diagnosis of breast metastases, a combination of techniques is needed to differentiate these lesions from primary breast carcinoma or even benign breast lesions. Multiple imaging methods may be used to evaluate these patients, including mammography, ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography (PET/CT)...
May 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28481477/evaluation-of-the-effectiveness-of-the-prepectoral-breast-reconstruction-with-braxon-dermal-matrix-first-multicenter-european-report-on-100-cases
#16
Raghavan Vidya, Jaume Masià, Simon Cawthorn, Giorgio Berna, Fernando Bozza, Alexander Gardetto, Agnieszka Kołacińska, Francesco Dell'Antonia, Cesare Tiengo, Franco Bassetto, Glenda G Caputo, Maurizio Governa
We report the outcomes of the European prospective study on prepectoral breast reconstruction using preshaped acellular dermal matrix for complete breast implant coverage. Seventy-nine patients were enrolled between April 2014 and August 2015 all over Europe using a single protocol for patient selection and surgical procedure, according to the Association of Breast Surgery and British Association of Plastic Reconstructive and Aesthetic Surgeons joint guidelines for the use of acellular dermal matrix in breast surgery...
May 8, 2017: Breast Journal
https://www.readbyqxmd.com/read/28481133/oral-1-generation-rat-reproduction-study-of-isobornyl-acetate-an-evaluation-through-sexual-maturity-in-the-f1-generation
#17
Valerie T Politano, Elise M Lewis, Alan M Hoberman, Robert M Diener, Anne Marie Api, Atish Patel
Reproductive toxicity of isobornyl acetate (IA), a widely used fragrance ingredient, was investigated in a 1-generation reproduction study in which 25 Crl: CD (Sprague-Dawley) rats/sex/group were gavaged with dosages of 0 (corn oil vehicle), 30, 100, or 300 mg/kg/d during premating, mating, gestation, and lactation. After weaning, 25 F1 generation pups/sex/dosage group were randomly selected for evaluation until sexual maturity. The following parameters were evaluated in P generation males and females: viability, clinical signs, body weights, feed consumption, mating and fertility, organ weights, gross and microscopic observations, sperm assessments (motility and concentration), natural delivery and litter observations, and ovarian follicle counts...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28476310/intra-operative-techniques-to-reduce-the-risk-of-capsular-contracture-in-patients-undergoing-aesthetic-breast-augmentation-a-review
#18
REVIEW
J D Horsnell, A E Searle, P A Harris
BACKGROUND: Capsular contracture is a significant complication following aesthetic breast augmentation. Efforts to reduce this incidence have focused on the surgical approach, implant selection and IV antibiotics. Intra-operative methods to reduce the risk have had less investigation. This review focuses on these interventions and will document evidence to support pocket irrigation, nipple shields, drains and the use of an implant insertion funnel. METHODS: A comprehensive review of Pubmed, Scopus and Embase was performed to identify relevant papers published since 2000...
May 2, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28473070/acr-appropriateness-criteria-%C3%A2-evaluation-of-nipple-discharge
#19
Su-Ju Lee, Sunita Trikha, Linda Moy, Paul Baron, Roberta M diFlorio, Edward D Green, Samantha L Heller, Anna I Holbrook, Alana A Lewin, Ana P Lourenco, Bethany L Niell, Priscilla J Slanetz, Ashley R Stuckey, Nina S Vincoff, Susan P Weinstein, Monica M Yepes, Mary S Newell
Appropriate imaging evaluation of nipple discharge depends the nature of the discharge. Imaging is not indicated for women with physiologic nipple discharge. For evaluation of pathologic nipple discharge, multiple breast imaging modalities are rated for evidence-based appropriateness under various scenarios. For women age 40 or older, mammography or digital breast tomosynthesis (DBT) should be the initial examination. Ultrasound is usually added as a complementary examination, with some exceptions. For women age 30 to 39, either mammogram or ultrasound may be used as the initial examination on the basis of institutional preference...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28472588/the-effects-of-different-breastfeeding-training-techniques-given-for-primiparous-mothers-before-discharge-on-the-incidence-of-cracked-nipples
#20
Aysun Eksioglu, Yesim Yesil, Dilek Demir Gungor, Esin Ceber Turfan
OBJECTIVE: This research investigated the effects of different breastfeeding training techniques for primiparous mothers before discharge on the incidence of cracked nipples. MATERIALS AND METHODS: This was a controlled intervention study that was carried out between 2015 and 2016 on 90 mothers living in İzmir. The mothers were divided into three groups: the demonstration-based training group, brochure group, and routine care-receiving group. The mothers in the "brochure group" were provided with breastfeeding training brochures...
May 4, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
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