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Ocular Surface Squamous Neoplasms

Mehenaz Hanbazazh, Kymberly A Gyure
CONTEXT: - Human papillomavirus (HPV) has a well-known role in the pathogenesis of squamous cell carcinoma and precursor lesions of the cervix, anogenital region, and head and neck, but its role in the development of squamous neoplasms of the eye, particularly the conjunctiva, remains unclear. OBJECTIVE: - To review recent evidence implicating HPV in the pathophysiology of ocular lesions. DATA SOURCES: - Published articles obtained from a PubMed search of the English literature were the primary sources for this review...
June 2018: Archives of Pathology & Laboratory Medicine
Amanda B Moyer, Jordan Roberts, Randall J Olsen, Patricia Chévez-Barrios
BACKGROUND: Human papillomavirus (HPV) is a causative agent for intraepithelial squamous neoplasms, particularly on mucosal surfaces. HPV has a well-established association with squamous cell carcinoma (SCC) of the oropharynx and genital tract, and recent studies suggest a potential role in ocular and periocular squamous neoplasms. Multiple high-risk HPV genotypes are associated with histologically similar squamous neoplasms, and some HPV genotypes have been differentially associated with high- or low-grade lesions...
March 6, 2018: American Journal of Dermatopathology
Kim Vieira Kayat, Paulo Elias Correa Dantas, Sérgio Felberg, Maria Antonieta Galvão, Mauro Ajaj Saieg
PURPOSE: Surface tumors of the eye comprise an ample spectrum of diseases with various clinical manifestations. Diagnosis has been traditionally achieved through core biopsies, but cytology is an innovative, fast, and minimally invasive method. The objective of this study was to investigate the use of exfoliative cytology as an alternative method for the detection of ocular surface squamous neoplasm (OSSN). METHODS: Exfoliative cytology of the lesions was performed by collecting smears using plastic brushes followed by smearing the cells onto slides and subsequently fixing them in 90% alcohol...
January 2017: Cornea
Dilip Kumar Mishra, Uppala Veena, Swathi Kaliki, Abhinav Reddy Kethiri, Virender S Sangwan, Mohammed Hasnat Ali, Milind N Naik, Vivek Singh
Ocular Surface Squamous Neoplasm (OSSN) is the neoplasia arising from the conjunctiva, cornea and limbus. OSSN ranges from mild, moderate, severe dysplasia, carcinoma in situ (CIS) to squamous cell carcinoma (SCC). Recent findings on cancer stem cells theory indicate that population of stem-like cell as in neoplasia determines its heterogeneity and complexity leading to varying tumor development of metastatic behavior and recurrence. Cancer stem cell markers are not much explored in the cases of OSSN. In the present study, we aim to evaluate the expression of stem cells using stem cell markers mainly p63, ABCG2, c-KIT (CD117) and CD44 in OSSN tissue, which could have prognostic significance...
2016: PloS One
Maria J Suarez, Roxana Rivera-Michlig, Sander Dubovy, Fausto J Rodriguez
BACKGROUND: Patients with xeroderma pigmentosum (XP) are strongly predisposed to the development of numerous cutaneous cancers. However, the extent of ocular pathology in these patients has not been adequately studied. METHODS: We conducted a retrospective study of tumors involving the ocular surface and ocular adnexa from 6 XP patients. Histopathological evaluation and immunohistochemistry was performed using antibodies directed against the most common mutated proteins in XP (XPA, XPC, and XPD)...
December 2015: Ocular Oncology and Pathology
Passara Jongkhajornpong, Takahiro Nakamura, Chie Sotozono, Maho Nagata, Tsutomu Inatomi, Shigeru Kinoshita
ATP-binding cassette subfamily B member 5 (ABCB5) is a new member of the ATP-binding cassette superfamily and has been reported as a novel marker for limbal stem cell (LSC), which is essential for corneal homeostasis. ABCB5 expression has also been discovered in the subpopulation of several cancer cells containing the cancer stem cell (CSC). However, the pathogenetic relationship between LSC and CSC and ABCB5 in the ocular surface squamous neoplasm (OSSN) is still entirely unknown. To improve understanding of the role of ABCB5 in OSSN, we performed immunohistochemistry for ABCB5 in nine OSSN case series...
February 4, 2016: Scientific Reports
Viviana Patricia Lezcano Carduz, David Mingo Botín, Sonia Pilar Durán Poveda
PURPOSE: To report a case of conjunctival squamous cell carcinoma in a patient with psoriasis treated with tumor necrosis factor-alpha inhibitors. METHODS: Case report and review of the literature. RESULTS: A 44-year-old white woman presented to our hospital 1 year after developing a rapidly growing nodular lesion with papillomatous characteristics on the bulbar conjunctiva. The patient had a medical history of psoriasis since childhood and psoriatic arthritis since 2009...
July 2015: Cornea
Sheetal Chauhan, Seema Sen, Anjana Sharma, Radhika Tandon, Seema Kashyap, Neelam Pushker, Murugesan Vanathi, Namrata Sharma
CONTEXT: Ocular surface squamous neoplasia (OSSN) is the most common tumor of conjunctival epithelium associated with risk of permanent visual impairment. It includes conjunctival intraepithelial neoplasia and squamous cell carcinoma. Although American Joint Committee on Cancer-TNM (AJCC-TNM) staging is commonly used in various tumors, it has only recently been described for OSSN. OBJECTIVES: To evaluate the prognostic relevance of AJCC-TNM staging and the clinicopathological features in OSSN...
November 2014: Archives of Pathology & Laboratory Medicine
Lazaros Konstantinidis, Dawn Roberts, R Douglas Errington, Andrzej Kacperek, Heinrich Heimann, Bertil Damato
BACKGROUND: Collateral damage to upper eyelid margin during proton beam radiotherapy (PBR) for choroidal melanoma may cause squamous metaplasia of the tarsal conjunctiva with keratinisation, corneal irritation, discomfort and, rarely, corneal perforation. We evaluated transpalpebral PBR as a means of avoiding collateral damage to the upper eyelid margin without increasing the risk of failure of local tumour control. METHODS: Retrospective study of consecutive patients who underwent PBR for choroidal melanoma between 1992 and 2007 at the Royal Liverpool University Hospital and the Douglas Cyclotron at Clatterbridge Cancer Centre, UK...
February 2015: British Journal of Ophthalmology
Mika Tanabe, Hiroshi Yoshikawa, Yoko Onishi, Ri-ichiro Kohno, Tatsuro Ishibashi
PURPOSE: To evaluate location, treatment and clinical course in cases of ocular surface squamous neoplasia (OSSN). METHODS: Thirty-four cases with OSSN [conjunctival intraepithelial neoplasia (CIN) 17 cases; squamous cell carcinoma (SCC) 17 cases] treated in Kyushu University hospital from 2000 to 2011 were retrospectively studied. RESULT: Lesions of CIN were observed in the conjunctiva bulbar in sixteen cases (16/17), and in eleven of those, the lesions were seen in the nasal part (nasal : lateral = 11 : 6)...
May 2014: Nippon Ganka Gakkai Zasshi
M Palamar, E Kaya, S Egrilmez, T Akalin, A Yagci
OBJECTIVE: To evaluate the long-term efficacy of amniotic membrane transplantation for ocular surface reconstruction in the surgical management of ocular surface squamous neoplasia (OSSN). METHODS: OSSN in 21 patients (7 female, 14 male patients) was managed with excisional biopsy, cryotherapy, corneal epitheliectomy with absolute alcohol application when the cornea is involved, lamellar sclerectomy and adjunctional absolute alcohol application to the base when episclera is involved, and ocular surface reconstruction with cryopreserved amniotic membrane transplantation...
September 2014: Eye
Richard A D Mills
No abstract text is available yet for this article.
May 2014: Clinical & Experimental Ophthalmology
C E Margo, A A White
No abstract text is available yet for this article.
May 2014: Eye
Benjamin J Thomas, Anat Galor, Afshan A Nanji, Fouad El Sayyad, Jianhua Wang, Sander R Dubovy, Madhura G Joag, Carol L Karp
The development of optical coherence tomography (OCT) technology has helped to usher in a new era of in vivo diagnostic imaging of the eye. The utilization of OCT for imaging of the anterior segment and ocular surface has evolved from time-domain devices to spectral-domain devices with greater penetrance and resolution, providing novel images of anterior segment pathology to assist in diagnosis and management of disease. Ocular surface squamous neoplasia (OSSN) is one such pathology that has proven demonstrable by certain anterior segment OCT machines, specifically the newer devices capable of performing ultra high-resolution OCT (UHR-OCT)...
January 2014: Ocular Surface
Afshan A Nanji, Christina S Moon, Anat Galor, Julia Sein, Patrick Oellers, Carol L Karp
PURPOSE: Treatment for ocular surface squamous neoplasia (OSSN) has historically been surgery, but nonsurgical interventions are increasingly used. Treatment with interferon is efficacious, but evidence is needed regarding recurrence and complication rates in comparison with surgery. The objective of this study is to compare the recurrence and complication rates of surgical treatment and interferon treatment for OSSN. DESIGN: A matched, case-control study. PARTICIPANTS: Ninety-eight patients with OSSN, 49 of whom were treated with interferon (IFN) α2b therapy and 49 of whom were treated with surgical intervention...
May 2014: Ophthalmology
Thomas P Moloney, Tanya Trinh, Jonathon J Farrah
Conjunctival mucoepidermoid carcinoma is a very rare but highly aggressive conjunctival neoplasm with 42 previously reported cases. We report the case of a 56-year-old male with a left ocular surface squamous neoplasm, which was subsequently treated with excision and autoconjunctival graft. Histopathology of the operative specimen reported a low-grade conjunctival mucoepidermoid carcinoma, and the patient was then treated with an adjunctive course of mitomycin C. On review 10 months after lesion excision, there was no recurrence, and the patient was otherwise well...
2014: Clinical Ophthalmology
Marie B Nguena, Jan G van den Tweel, William Makupa, Victor H Hu, Helen A Weiss, Stephen Gichuhi, Matthew J Burton
OBJECTIVE: To examine the reliability of clinical examination and in vivo confocal microscopy (IVCM) in distinguishing ocular surface squamous neoplasia (OSSN) from benign conjunctival lesions. DESIGN: Case-control study. PARTICIPANTS: Sixty individuals with conjunctival lesions (OSSN and benign) and 60 age-matched controls with normal conjunctiva presenting to Kilimanjaro Christian Medical Centre, Moshi, Tanzania. METHODS: Participants were examined and photographed, and IVCM was performed...
February 2014: Ophthalmology
David B Samimi, Gloria B Chiu, Michael A Burnstine
A 50-year-old man presented with a papillomatous tarsoconjunctival tumor involving the medial two-thirds of the left upper eyelid. Office biopsy revealed papillary squamous cell carcinoma (SCCA). Rapid tumor growth with caruncular and forniceal conjunctival involvement continued, despite a trial of weekly interferon-α2b intralesional injection therapy. Surgical excision with clear margins resulted in a large upper eyelid defect. The suspicion for recurrence remained, given the aggressive nature of the tumor...
September 2014: Ophthalmic Plastic and Reconstructive Surgery
Jaime Badilla, Silvia González-Arias
INTRODUCTION: Total upper and lower eyelid loss due to carcinoma or trauma while conserving a functioning eye is rarely seen. In such cases being able to maintain the ocular surface may prove to be a surgical challenge, more so when there is a history of tumor recurrence, multiple procedures or tissue loss that exceeds the palpebral region, thus limiting the reconstructive options. CASE AND TECHNIQUE: We present a case report where a scalping forehead transposition flap pedicled on the superficial temporal artery territory was performed to reconstruct a full thickness skin defect that involved the dorsum of the nose, cheek, upper and lower eyelids...
June 2014: Orbit
Mark Woods, Sharron Chow, Benjamin Heng, Wendy Glenn, Noel Whitaker, Dale Waring, Jenna Iwasenko, William Rawlinson, Minas T Coroneo, Denis Wakefield, Nick Di Girolamo
PURPOSE: Human papillomavirus (HPV) infection has been implicated as a possible inducing factor for benign and neoplastic ocular surface diseases such as pterygia and ocular-surface squamous neoplasia (OSSN). However, the wide range in HPV prevalence previously reported for both diseases adds controversy to, and highlights the limitations of, this field. The aim of this study was to determine the prevalence of HPV in pterygia and OSSN and to devise a standardized approach for detecting viral DNA in ocular tissue samples...
December 2013: Investigative Ophthalmology & Visual Science
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