Luregn J Schlapbach, Devika Ganesamoorthy, Clare Wilson, Sainath Raman, Shane George, Peter J Snelling, Natalie Phillips, Adam Irwin, Natalie Sharp, Renate Le Marsney, Arjun Chavan, Allison Hempenstall, Seweryn Bialasiewicz, Anna D MacDonald, Keith Grimwood, Jessica C Cling, Stephen J McPherson, Antje Blumenthal, Myrsini Kaforou, Michael Levin, Jethro A Herberg, Kristen S Gibbons, Lachlan J M Coin
BACKGROUND: Sepsis is defined as dysregulated host response to infection that leads to life-threatening organ dysfunction. Biomarkers characterising the dysregulated host response in sepsis are lacking. We aimed to develop host gene expression signatures to predict organ dysfunction in children with bacterial or viral infection. METHODS: This cohort study was done in emergency departments and intensive care units of four hospitals in Queensland, Australia, and recruited children aged 1 month to 17 years who, upon admission, underwent a diagnostic test, including blood cultures, for suspected sepsis...
March 18, 2024: Lancet Child & Adolescent Health