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https://www.readbyqxmd.com/read/27908788/time-to-wake-up-studying-neurovascular-coupling-and-brain-wide-circuit-function-in-the-un-anesthetized-animal
#1
REVIEW
Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T Winder, Zhifeng Liang, Lilith Antinori, Patrick J Drew, Nanyin Zhang
Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-based and resting-state brain dynamics in humans by inferring neural activity from blood-oxygenation-level dependent (BOLD) signal changes. An accurate interpretation of the hemodynamic changes that underlie fMRI signals depends on the understanding of the quantitative relationship between changes in neural activity and changes in cerebral blood flow, oxygenation and volume. While there has been extensive study of neurovascular coupling in anesthetized animal models, anesthesia causes large disruptions of brain metabolism, neural responsiveness and cardiovascular function...
November 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27893138/achieving-the-triple-aim-through-disruptive-innovations-in-self-care
#2
Kavita P Bhavan, Deepak Agrawal, Frederick Cerise
No abstract text is available yet for this article.
November 22, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27888888/laser-assisted-delivery-to-treat-facial-scars
#3
REVIEW
Jill S Waibel, Ashley Rudnick
Treatment of facial scars is a multispecialty endeavor for optimal patient recovery. One new innovation helping in facial scar treatments are lasers. Fractional laser predictably (tunable) disrupts the barrier of the skin creating deep channels that allow the delivery of drug and cellular materials; this is called laser-assisted drug delivery (LAD). Without exception thus far, LAD has been found to enhance the local uptake of any drug or substance applied to the skin. These zones may be used postoperatively to deliver drugs and other substances to create an enhanced scar therapeutic response to drug or substance applied to the skin...
February 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/27882771/functional-marine-metagenomic-screening-for-anti-quorum-sensing-and-anti-biofilm-activity
#4
Karin Yaniv, Karina Golberg, Esti Kramarsky-Winter, Robert Marks, Alina Pushkarev, Oded Béjà, Ariel Kushmaro
Quorum sensing (QS), a cell-to-cell communication process, entails the production of signaling molecules that enable synchronized gene expression in microbial communities to regulate myriad microbial functions, including biofilm formation. QS disruption may constitute an innovative approach to the design of novel antifouling and anti-biofilm agents. To identify novel quorum sensing inhibitors (QSI), 2,500 environmental bacterial artificial chromosomes (BAC) from uncultured marine planktonic bacteria were screened for QSI activity using soft agar overlaid with wild type Chromobacterium violaceum as an indicator...
November 24, 2016: Biofouling
https://www.readbyqxmd.com/read/27882313/experiences-in-tick-control-by-acaricide-in-the-traditional-cattle-sector-in-zambia-and-burkina-faso-possible-environmental-and-public-health-implications
#5
REVIEW
Daniele De Meneghi, Frédéric Stachurski, Hassane Adakal
Livestock, especially cattle, play a paramount role in agriculture production systems, particularly in poor countries throughout the world. Ticks and tick-borne diseases (TBDs) have an important impact on livestock and agriculture production in sub-Saharan Africa. The authors review the most common methods used for the control of ticks and TBDs. Special emphasis is given to the direct application of acaricides to the host animals. The possible environmental and public health adverse effects (i.e., risks for the workers, residues in the environment and in food products of animal origin) are mentioned...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27875480/innovative-treatments-for-back-pain
#6
G Lorimer Moseley
Innovation involves asking new questions, or taking new approaches to old questions. For a problem as old as back pain, one might expect innovations to be rare. That back pain has been the most burdensome non-fatal health condition for over 25 years, and that the treatments that are available are not very effective, clearly points to the need for innovative approaches. The most eye-catching innovations of the last decade have taken novel approaches to the intervertebral disk, but the disconnect between back pain and structural pathology of the spine suggest that the impact of any so targeted approaches will be limited...
November 21, 2016: Pain
https://www.readbyqxmd.com/read/27867752/comparing-the-effectiveness-of-polymer-debriding-devices-using-a-porcine-wound-biofilm-model
#7
Holly N Wilkinson, Andrew J McBain, Christian Stephenson, Matthew J Hardman
Objective: Debridement to remove necrotic and/or infected tissue and promote active healing remains a cornerstone of contemporary chronic wound management. While there has been a recent shift toward less invasive polymer-based debriding devices, their efficacy requires rigorous evaluation. Approach: This study was designed to directly compare monofilament debriding devices to traditional gauze using a wounded porcine skin biofilm model with standardized application parameters. Biofilm removal was determined using a surface viability assay, bacterial counts, histological assessment, and scanning electron microscopy (SEM)...
November 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27852690/maternal-use-of-mild-analgesics-during-pregnancy-associated-with-reduced-anogenital-distance-in-sons-a-cohort-study-of-1027-mother-child-pairs
#8
Dorte Vesterholm Lind, Katharina M Main, Henriette Boye Kyhl, David Møbjerg Kristensen, Jorma Toppari, Helle Raun Andersen, Marianne Skovsager Andersen, Niels E Skakkebæk, Tina Kold Jensen
STUDY QUESTION: Is maternal use of mild analgesics in pregnancy associated with anogenital distance (AGD)-the distance from the anus to the genitals-in the offspring? SUMMARY ANSWER: Maternal use of mild analgesics [especially simultaneous use of paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs)] during pregnancy was associated with a shorter AGD in boys whereas no effect was found in girls. WHAT IS KNOWN ALREADY: Mild analgesics including paracetamol (acetaminophen) and NSAIDs (e...
November 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27832703/hiv-and-sti-knowledge-testing-and-risk-among-adult-crack-users-in-mexico-city-baseline-findings-from-a-feasibility-study
#9
Alice Cepeda, Jessica Frankeberger, Jennifer L Bailey, Kathryn M Nowotny, Guillermina Natera-Rey, Avelardo Valdez
Recent research has documented crack cocaine's increasing spread in Mexico, which is likely to contribute to the rapid transmission of HIV and other sexually transmitted infections (STIs). In Mexico, crack use is increasing most rapidly in vulnerable, hard-to-reach populations, where little is known about risk behaviors. This report aims to present baseline data regarding HIV and STI knowledge and testing prevalence from an innovative projection mapping HIV intervention, in which 3-D illusions, animation, and visual text graphics and sound are projected onto buildings with health messages that were designed to disrupt everyday life and connect with the target population...
November 10, 2016: AIDS Care
https://www.readbyqxmd.com/read/27820710/innovative-disruption-in-the-world-of-neuromuscular-blockade-what-is-the-state-of-the-art
#10
Mohamed Naguib, Ken B Johnson
No abstract text is available yet for this article.
November 7, 2016: Anesthesiology
https://www.readbyqxmd.com/read/27814692/a-set-of-genes-conserved-in-sequence-and-expression-traces-back-the-establishment-of-multicellularity-in-social-amoebae
#11
Christina Schilde, Hajara M Lawal, Angelika A Noegel, Ludwig Eichinger, Pauline Schaap, Gernot Glöckner
BACKGROUND: The developmental cycle of Dictyostelid amoebae represents an early form of multicellularity with cell type differentiation. Mutant studies in the model Dictyostelium discoideum revealed that its developmental program integrates the actions of genes involved in signal transduction, adhesion, motility, autophagy and cell wall and matrix biosynthesis. However, due to functional redundancy and fail safe options not required in the laboratory, this single organism approach cannot capture all essential genes...
November 4, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27797342/high-throughput-screening-in-niche-based-assay-identifies-compounds-to-target-preleukemic-stem-cells
#12
Bastien Gerby, Diogo F T Veiga, Jana Krosl, Sami Nourreddine, Julianne Ouellette, André Haman, Geneviève Lavoie, Iman Fares, Mathieu Tremblay, Véronique Litalien, Elizabeth Ottoni, Milena Kosic, Dominique Geoffrion, Joël Ryan, Paul S Maddox, Jalila Chagraoui, Anne Marinier, Josée Hébert, Guy Sauvageau, Benjamin H Kwok, Philippe P Roux, Trang Hoang
Current chemotherapies for T cell acute lymphoblastic leukemia (T-ALL) efficiently reduce tumor mass. Nonetheless, disease relapse attributed to survival of preleukemic stem cells (pre-LSCs) is associated with poor prognosis. Herein, we provide direct evidence that pre-LSCs are much less chemosensitive to existing chemotherapy drugs than leukemic blasts because of a distinctive lower proliferative state. Improving therapies for T-ALL requires the development of strategies to target pre-LSCs that are absolutely dependent on their microenvironment...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27793177/approaches-to-modernize-the-combination-drug-development-paradigm
#13
REVIEW
Daphne Day, Lillian L Siu
Recent advances in genomic sequencing and omics-based capabilities are uncovering tremendous therapeutic opportunities and rapidly transforming the field of cancer medicine. Molecularly targeted agents aim to exploit key tumor-specific vulnerabilities such as oncogenic or non-oncogenic addiction and synthetic lethality. Additionally, immunotherapies targeting the host immune system are proving to be another promising and complementary approach. Owing to substantial tumor genomic and immunologic complexities, combination strategies are likely to be required to adequately disrupt intricate molecular interactions and provide meaningful long-term benefit to patients...
October 28, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27785576/disruptive-innovation-and-eu-health-policy
#14
EDITORIAL
Bengt Jönsson
No abstract text is available yet for this article.
October 26, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/27781449/control-and-prediction-for-blackouts-caused-by-frequency-collapse-in-smart-grids
#15
Chengwei Wang, Celso Grebogi, Murilo S Baptista
The electric power system is one of the cornerstones of modern society. One of its most serious malfunctions is the blackout, a catastrophic event that may disrupt a substantial portion of the system, playing havoc to human life and causing great economic losses. Thus, understanding the mechanisms leading to blackouts and creating a reliable and resilient power grid has been a major issue, attracting the attention of scientists, engineers, and stakeholders. In this paper, we study the blackout problem in power grids by considering a practical phase-oscillator model...
September 2016: Chaos
https://www.readbyqxmd.com/read/27771302/blurred-lines-dysbiosis-and-probiotics-in-the-intensive-care-unit
#16
Lee E Morrow, Paul Wischmeyer
Clinicians have traditionally dichotomized bacteria as friendly commensals or harmful pathogens. However, the line separating the two has become blurred with the recognition that the intestinal microbiome is a complex entity wherein species can shift sides - from friend to foe and back again - based on crucial factors in their local environment. Significant disruptions in the homeostasis of the microbiome, a phenomenon called 'dysbiosis,' is increasingly associated with a host of untoward effects. Intensive care unit patients are at high risk for dysbiosis given high rates of antibiotic use, acute changes in diet, and the stress of critical illness...
October 19, 2016: Chest
https://www.readbyqxmd.com/read/27763557/decrystallization-of-crystals-using-gold-nano-bullets-and-the-metal-assisted-and-microwave-accelerated-decrystallization-technique
#17
Nishone Thompson, Zainab Boone-Kukoyi, Raquel Shortt, Carisse Lansiquot, Bridgit Kioko, Enock Bonyi, Salih Toker, Birol Ozturk, Kadir Aslan
Gout is caused by the overproduction of uric acid and the inefficient metabolism of dietary purines in humans. Current treatments of gout, which include anti-inflammatory drugs, cyclooxygenase-2 inhibitors, and systemic glucocorticoids, have harmful side-effects. Our research laboratory has recently introduced an innovative approach for the decrystallization of biological and chemical crystals using the Metal-Assisted and Microwave-Accelerated Evaporative Decrystallization (MAMAD) technique. In the MAMAD technique, microwave energy is used to heat and activate gold nanoparticles that behave as "nano-bullets" to rapidly disrupt the crystal structure of biological crystals placed on planar surfaces...
October 18, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27756833/the-frontal-cortex-as-a-network-hub-controlling-mood-and-cognition-probing-its-neurochemical-substrates-for-improved-therapy-of-psychiatric-and-neurological-disorders
#18
Mark J Millan, Jean-Michel Rivet, Alain Gobert
The highly-interconnected and neurochemically-rich frontal cortex plays a crucial role in the regulation of mood and cognition, domains disrupted in depression and other central nervous system disorders, and it is an important site of action for their therapeutic control. For improving our understanding of the function and dysfunction of the frontal cortex, and for identifying improved treatments, quantification of extracellular pools of neuromodulators by microdialysis in freely-moving rodents has proven indispensable...
October 17, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27754186/sp-04-1-the-role-of-natriuretic-peptides-in-the-pathogenesis-of-cardiovascular-diseases
#19
Zhanna Kobalava
The burden of cardiovascular diseases (CVD) in general and heart failure (HF) in particular continues to increase worldwide. CVD are major contributors to death and morbidity and recognized as important drivers of healthcare expenditure. Chronic overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in human hypertension and HF pathophysiology. RAAS is fundamental in the overall regulation of cardiovascular homeostasis through the actions of hormones, which regulate vascular tone, and specifically blood pressure through vasoconstriction and renal sodium and water retention...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753849/ed-03-4-high-tech-in-blood-pressure-monitoring-where-are-we-going
#20
Seung Woo Park
Rapid progress of mobile information technologies such as wearable sensors, wireless communication, and world-wide use of smartphone cause digital health innovations. In the field of hypertension, wearable blood pressure (BP) monitoring and its wireless transfer to anywhere through smartphone, mobile smartphone apps, and cuffless blood pressure monitoring system are expected to change the way of diagnosis and management of hypertension. Home BP monitoring would be easier and wireless data transfer to health care providers would be common...
September 2016: Journal of Hypertension
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