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https://www.readbyqxmd.com/read/29775283/magnetic-glycol-chitin-based-hydrogel-nanocomposite-for-combined-thermal-and-d-amino-acid-assisted-biofilm-disruption
#1
Eric C Abenojar, Sameera Wickramasinghe, Minseon Ju, Sarika Uppaluri, Alison Klika, Jaiben George, Wael Barsoum, Salvatore J Frangiamore, Carlos A Higuera-Rueda, Anna Cristina S Samia
Bacterial biofilms are highly antibiotic resistant microbial cell associations that lead to chronic infections. Unlike free-floating planktonic bacterial cells, the biofilms are encapsulated in a hardly penetrable extracellular polymeric matrix and, thus, demand innovative approaches for treatment. Recent advancements on the development of gel-nanocomposite systems with tailored therapeutic properties provide promising routes to develop novel antimicrobial agents that can be designed to disrupt and completely eradicate preformed biofilms...
May 18, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29769238/strength-in-numbers-opportunities-for-enhancing-the-development-of-effective-treatments-for-type-1-diabetes-the-trialnet-experience
#2
Carla J Greenbaum, Cate Speake, Jeffrey Krischer, Jane Buckner, Peter A Gottlieb, Desmond A Schatz, Kevan C Herold, Mark A Atkinson
The early to mid-1980s were an inflection point in the history of type 1 diabetes research. Two landmark events occurred: the initiation of immune-based interventions seeking to prevent type 1 diabetes and the presentation of an innovative model describing the disorder's natural history. Both formed the basis for hundreds of subsequent studies designed to achieve a dramatic therapeutic goal-a means to prevent and/or reverse type 1 diabetes. However, the need to screen large numbers of individuals and prospectively monitor them using immunologic and metabolic tests for extended periods of time suggested such efforts would require a large collaborative network...
May 16, 2018: Diabetes
https://www.readbyqxmd.com/read/29765271/approach-to-reconstruction-of-nasal-defects
#3
REVIEW
Berkay Başağaoğlu, Kausar Ali, Pierce Hollier, Renata S Maricevich
The nose is the most central and anterior projecting facial feature. Therefore, the presence of a defect is easily noticeable to the untrained eye. Return of the defect to the original form is an achievable end goal of reconstruction, necessitating appropriate reformation of three-dimensional geometry, proper establishment of symmetry, and excellent color and texture match to the adjacent structures. Regarding its physiological importance, disruption of the normal function may cause respiratory obstruction and contribute to patient distress...
May 2018: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/29759831/sustaining-and-disruptive-innovation-in-clinical-electrophysiology-the-subcutaneous-implantable-cardioverter-defibrillator-in-the-young
#4
EDITORIAL
Elizabeth Vickers Saarel
No abstract text is available yet for this article.
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29749932/cardiac-optogenetics-2018
#5
REVIEW
Patrick M Boyle, Thomas V Karathanos, Natalia A Trayanova
Cardiac optogenetics is an emergent research area involving the delivery of light-sensitive proteins (opsins) to excitable heart tissue to enable optical modulation of cardiac electrical function. Optogenetic stimulation has many noteworthy advantages over conventional electrical methods, including selective electrophysiological modulation in specifically targeted cell subpopulations, high-resolution spatiotemporal control via patterned illumination, and use of different opsins to elicit inward or outward transmembrane current...
February 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29740421/toxicity-of-food-grade-tio-2-to-commensal-intestinal-and-transient-food-borne-bacteria-new-insights-using-nano-sims-and-synchrotron-uv-fluorescence-imaging
#6
Joanna M Radziwill-Bienkowska, Pauline Talbot, Jasper B J Kamphuis, Véronique Robert, Christel Cartier, Isabelle Fourquaux, Esther Lentzen, Jean-Nicolas Audinot, Frédéric Jamme, Matthieu Réfrégiers, Jacek K Bardowski, Philippe Langella, Magdalena Kowalczyk, Eric Houdeau, Muriel Thomas, Muriel Mercier-Bonin
Titanium dioxide (TiO2 ) is commonly used as a food additive (E171 in the EU) for its whitening and opacifying properties. However, a risk of intestinal barrier disruption, including dysbiosis of the gut microbiota, is increasingly suspected because of the presence of a nano-sized fraction in this additive. We hypothesized that food-grade E171 and Aeroxyde P25 (identical to the NM-105 OECD reference nanomaterial in the European Union Joint Research Centre) interact with both commensal intestinal bacteria and transient food-borne bacteria under non-UV-irradiated conditions...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29735000/value-and-payment-in-sleep-medicine
#7
Emerson M Wickwire, Tilak Verma
Value, like beauty, exists in the eye of the beholder. This article places the value of clinical sleep medicine services in historical context and presents a vision for the value-based sleep of the future. First, the history of value and payment in sleep medicine is reviewed from the early days of the field, to innovative disruption, to the widespread adoption of home sleep apnea testing. Next, the importance of economic perspective is discussed, with emphasis on cost containment and cost-shifting between payers, employers, providers, and patients...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29731703/metabolic-syndrome-and-neuroprotection
#8
REVIEW
Melisa Etchegoyen, Mariana H Nobile, Francisco Baez, Barbara Posesorski, Julian González, Néstor Lago, José Milei, Matilde Otero-Losada
Introduction: Over the years the prevalence of metabolic syndrome (MetS) has drastically increased in developing countries as a major byproduct of industrialization. Many factors, such as the consumption of high-calorie diets and a sedentary lifestyle, bolster the spread of this disorder. Undoubtedly, the massive and still increasing incidence of MetS places this epidemic as an important public health issue. Hereon we revisit another outlook of MetS beyond its classical association with cardiovascular disease (CVD) and Diabetes Mellitus Type 2 (DM2), for MetS also poses a risk factor for the nervous tissue and threatens neuronal function...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29715285/is-a-clean-river-fun-for-all-recognizing-social-vulnerability-in-watershed-planning
#9
Bethany B Cutts, Andrew J Greenlee, Natalie K Prochaska, Carolina V Chantrill, Annie B Contractor, Juliana M Wilhoit, Nancy Abts, Kaitlyn Hornik
Watershed planning can lead to policy innovation and action toward environmental protection. However, groups often suffer from low engagement with communities that experience disparate impacts from flooding and water pollution. This can limit the capacity of watershed efforts to dismantle pernicious forms of social inequality. As a result, the benefits of environmental changes often flow to more empowered residents, short-changing the power of watershed-based planning as a tool to transform ecological, economic, and social relationships...
2018: PloS One
https://www.readbyqxmd.com/read/29712841/symbiotic-polydnavirus-and-venom-reveal-parasitoid-to-its-hyperparasitoids
#10
Feng Zhu, Antonino Cusumano, Janneke Bloem, Berhane T Weldegergis, Alexandre Villela, Nina E Fatouros, Joop J A van Loon, Marcel Dicke, Jeffrey A Harvey, Heiko Vogel, Erik H Poelman
Symbiotic relationships may provide organisms with key innovations that aid in the establishment of new niches. For example, during oviposition, some species of parasitoid wasps, whose larvae develop inside the bodies of other insects, inject polydnaviruses into their hosts. These symbiotic viruses disrupt host immune responses, allowing the parasitoid's progeny to survive. Here we show that symbiotic polydnaviruses also have a downside to the parasitoid's progeny by initiating a multitrophic chain of interactions that reveals the parasitoid larvae to their enemies...
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29706467/hpv-molecular-pathways-and-targets
#11
REVIEW
Shilpi Gupta, Prabhat Kumar, Bhudev C Das
Infection of high-risk human papillomaviruses (HPVs) is a prerequisite for the development of cervical carcinoma. HPV infections are also implicated in the development of other types of carcinomas. Chronic or persistent infection of HPV is essential but HPV alone is inadequate, additional endogenous or exogenous cues are needed along with HPV to induce cervical carcinogenesis. The strategies that high-risk HPVs have developed in differentiating epithelial cells to reach a DNA-synthesis competent state leading to tumorigenic transformation are basically due to overexpression of the E6 and E7 oncoproteins and the activation of diverse cellular regulatory or signaling pathways that are targeted by them...
April 5, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29704833/regeneration-of-salicaceae-riparian-forests-in-the-northern-hemisphere-a-new-framework-and-management-tool
#12
REVIEW
Eduardo González, Vanesa Martínez-Fernández, Patrick B Shafroth, Anna A Sher, Annie L Henry, Virginia Garófano-Gómez, Dov Corenblit
Human activities on floodplains have severely disrupted the regeneration of foundation riparian shrub and tree species of the Salicaceae family (Populus and Salix spp.) throughout the Northern Hemisphere. Restoration ecologists initially tackled this problem from a terrestrial perspective that emphasized planting. More recently, floodplain restoration activities have embraced an aquatic perspective, inspired by the expanding practice of managing river flows to improve river health (environmental flows). However, riparian Salicaceae species occupy floodplain and riparian areas, which lie at the interface of both terrestrial and aquatic ecosystems along watercourses...
April 25, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29702133/primary-prevention-of-clostridium-difficile-infections-with-a-specific-probiotic-combining-lactobacillus-acidophilus-cl1285-l-casei-lbc80r-and-l-rhamnosus-clr2-a-critical-appraisal-of-the-evidence
#13
REVIEW
Lynne V McFarland, Noam Ship, Julie Auclair, Mathieu Millette
Clostridium difficile infections (CDI) have become the leading cause of healthcare-associated infections and causes outbreaks around the world. Although various new innovative treatments have been developed, preventive strategies using multi-faceted infection control programmes have not been as successful in reducing CDI rates. The major risk factor for CDI is the disruption of the normally protective gastrointestinal microbiota, typically by antibiotic use. Supplementation with specific probiotics has been found to be effective in preventing various negative outcomes, including antibiotic-associated diarrhoea and CDI...
April 24, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29696182/imagine-your-mood-study-design-and-protocol-of-a-randomized-controlled-micro-trial-using-app-based-experience-sampling-methodology-to-explore-processes-of-change-during-relapse-prevention-interventions-for-recurrent-depression
#14
Christien Slofstra, Nicola S Klein, Maaike H Nauta, Marieke Wichers, Nikolaos Batalas, Claudi L H Bockting
Background: Relapse prevention strategies include continuation of antidepressant medication and preventive psychological interventions. This study aims to gain understanding that may inform tailoring of relapse prevention to individual differences, to improve their effects. Such treatment personalization may be based on repeated assessments within one individual, using experience sampling methodology. As a first step towards informing decisions based on this methodology, insight is needed in individual differences in risk of relapse and response to treatment, and how relapse prevention strategies may differentially target vulnerability for relapse...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29684386/valuing-innovative-endoscopic-techniques-per-oral-endoscopic-myotomy-for-the-management-of-achalasia
#15
Eric D Shah, Andrew C Chang, Ryan Law
BACKGROUND AND AIMS: Unclear reimbursement for new and innovative endoscopic procedures can limit adoption in clinical practice despite effectiveness in clinical trials. The aim of this study was to determine maximum cost-effective reimbursement for per-oral endoscopic myotomy (POEM) in treating achalasia. METHODS: We constructed a decision analytic model assessing POEM versus laparoscopic Heller myotomy with Dor fundoplication (LHM) in managing achalasia from a payer perspective over a 1-year time horizon...
April 20, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29680623/enhancement-of-water-removing-and-the-quality-of-fried-purple-fleshed-sweet-potato-in-the-vacuum-frying-by-combined-power-ultrasound-and-microwave-technology
#16
Ya Su, Min Zhang, Bhesh Bhandari, Weiming Zhang
The combination of ultrasound and microwave in vacuum frying system was investigated to achieve higher drying efficiency and quality attributes of fried products. Purple-fleshed potato were used as test specimen and different power levels of microwave (0 W, 600 W, 800 W) and ultrasound (0 W, 300 W, 600 W) during vacuum frying. Drying kinetics, dielectric properties, moisture state variation and quality attributes of fried samples were measured in a vacuum frying (VF), and an innovatively designed ultrasound and microwave assisted vacuum frying (USMVF) equipment...
June 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29673565/scanning-the-horizon-for-high-value-add-manufacturing-science-accelerating-manufacturing-readiness-for-the-next-generation-of-disruptive-high-value-curative-cell-therapeutics
#17
Paul Hourd, David J Williams
BACKGROUND: Since the regenerative medicine sector entered the second phase of its development (RegenMed 2.0) more than a decade ago, there is increasing recognition that current technology innovation trajectories will drive the next translational phase toward the production of disruptive, high-value curative cell and gene-based regenerative medicines. AIM: To identify the manufacturing science problems that must be addressed to permit translation of these next generation therapeutics...
April 16, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29670715/the-effect-of-surface-topographical-changes-of-two-different-surface-treatments-rotary-instrument
#18
Nashwan-Ahmed Qaed, Bilal-Diab Mourshed, Hashem-Motahir Al-Shamiri, Nader Alaizari, Saleh-Sulaiman Alhamdah
Background: One of the major innovations in endodontics has been the introduction of nickel-titanium (NiTi) alloy. This study evaluated the surface topographical changes of two different surface treatments rotary instrument after instrumentation and sterilization. Material and Methods: 240 Extracted teeth were included in this study. 90 new AlphaKite and Revo-S NiTi rotary instruments were selected and divided into two groups (Group A 45 AlphaKite and group B 45 Revo-S)...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29662770/predicting-the-collapse-of-the-femoral-head-due-to-osteonecrosis-from-basic-methods-to-application-prospects
#19
REVIEW
Leilei Chen, GuoJu Hong, Bin Fang, Guangquan Zhou, Xiaorui Han, Tianan Guan, Wei He
Collapse of the femoral head is the most significant pathogenic complication arising from osteonecrosis of the femoral head. It is related to the disruption of the maintenance of cartilage and bone, and results in an impaired function of the vascular component. A method for predicting the collapse of the femoral head can be treated as a type of clinical index. Efforts in recent years to predict the collapse of the femoral head due to osteonecrosis include multiple methods of radiographic analysis, stress distribution analysis, finite element analysis, and other innovative methods...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29659151/story-making-as-methodology-disrupting-dominant-stories-through-multimedia-storytelling
#20
Carla Rice, Ingrid Mündel
In this essay, we discuss multimedia story-making methodologies developed through Re•Vision: The Centre for Art and Social Justice that investigates the power of the arts, especially story, to positively influence decision makers in diverse sectors. Our story-making methodology brings together majority and minoritized creators to represent previously unattended experiences (e.g., around mind-body differences, queer sexuality, urban Indigenous identity, and Inuit cultural voice) with an aim to building understanding and shifting policies/practices that create barriers to social inclusion and justice...
April 16, 2018: Canadian Review of Sociology, Revue Canadienne de Sociologie
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