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https://www.readbyqxmd.com/read/28103489/enhanced-degradation-of-organic-contaminants-in-water-by-peroxydisulfate-coupled-with-bisulfite
#1
Chengdu Qi, Xitao Liu, Yang Li, Chunye Lin, Jun Ma, Xiaowan Li, Huijuan Zhang
In this study, the bisulfite-peroxydisulfate system (S(IV)/PDS) widely used in polymerization was innovatively applied for organic contaminants degradation in water. The addition of S(IV) into PDS system remarkably enhanced the degradation efficiency of bisphenol A (BPA, a frequently detected endocrine disrupting chemical in the environments) from 17.0% to 84.7% within 360 min. The degradation efficiency of BPA in the S(IV)/PDS system followed pseudo-first-order kinetics, with rate constant values ranging from 0...
January 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28102908/addressing-critical-gaps-in-the-treatment-of-eating-disorders
#2
REVIEW
Alan E Kazdin, Ellen E Fitzsimmons-Craft, Denise E Wilfley
Remarkable progress has been made in developing psychosocial interventions for eating disorders and other mental disorders. Two priorities in providing treatment consist of addressing the research-practice gap and the treatment gap. The research-practice gap pertains to the dissemination of evidence-based treatments from controlled settings to routine clinical care. Closing the gap between what is known about effective treatment and what is actually provided to patients who receive care is crucial in improving mental health care, particularly for conditions such as eating disorders...
January 19, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28090510/augmented-and-virtual-reality-in-surgery-the-digital-surgical-environment-applications-limitations-and-legal-pitfalls
#3
REVIEW
Wee Sim Khor, Benjamin Baker, Kavit Amin, Adrian Chan, Ketan Patel, Jason Wong
The continuing enhancement of the surgical environment in the digital age has led to a number of innovations being highlighted as potential disruptive technologies in the surgical workplace. Augmented reality (AR) and virtual reality (VR) are rapidly becoming increasingly available, accessible and importantly affordable, hence their application into healthcare to enhance the medical use of data is certain. Whether it relates to anatomy, intraoperative surgery, or post-operative rehabilitation, applications are already being investigated for their role in the surgeons armamentarium...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28089207/delivery-dilemmas-how-drug-cryptomarket-users-identify-and-seek-to-reduce-their-risk-of-detection-by-law-enforcement
#4
Judith Aldridge, Rebecca Askew
BACKGROUND: Cryptomarkets represent an important drug market innovation by bringing buyers and sellers of illegal drugs together in a 'hidden' yet public online marketplace. We ask: How do cryptomarket drug sellers and buyers perceive the risks of detection and arrest, and attempt to limit them? METHODS: We analyse selected texts produced by vendors operating on the first major drug cryptomarket, Silk Road (N=600) alongside data extracted from the marketplace discussion forum that include buyer perspectives...
January 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28072752/a-simpler-blood-test-for-monitoring-kidney-transplant-recipients-a-disrupting-innovation
#5
Christine M Wu, Sundaram Hariharan
No abstract text is available yet for this article.
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28071841/attending-to-power-differentials-how-np-led-group-medical-visits-can-influence-the-management-of-chronic-conditions
#6
Laura Housden, Annette J Browne, Sabrina T Wong, Martin Dawes
OBJECTIVE: In Canada, primary care reform has encouraged innovations, including nurse practitioners (NPs) and group medical visits (GMVs). NP-led GMVs provide an opportunity to examine barriers and enablers to implementing this innovation in primary care. DESIGN: An instrumental case study design (n=3): two cases where NPs were using GMVs and one case where NPs were not using GMVs, was completed. In-depth interviews with patients and providers (N=24) and 10 hours of direct observation were completed...
January 10, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28045038/disruption-of-cell-adhesion-by-an-antibody-targeting-the-cell-adhesive-intermediate-x-dimer-of-human-p-cadherin
#7
Shota Kudo, Jose M M Caaveiro, Satoru Nagatoishi, Takamitsu Miyafusa, Tadashi Matsuura, Yukio Sudou, Kouhei Tsumoto
Human P-cadherin is a cell adhesion protein of the family of classical cadherins, the overexpression of which is correlated with poor prognosis in various types of cancer. Antibodies inhibiting cell-cell adhesion mediated by P-cadherin show clear therapeutic effect, although the mechanistic basis explaining their effectiveness is still unclear. Based on structural, physicochemical, and functional analyses, we have elucidated the molecular mechanism of disruption of cell adhesion by antibodies targeting human P-cadherin...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28032849/reflections-on-a-decade-of-face-transplantation
#8
Giorgio Giatsidis, Indranil Sinha, Bohdan Pomahac
On November 27, 2005, Isabelle Dinoire underwent the world's first partial face transplant in Amiens (France) after a dog attack had left her face severely disfigured. The abrupt surgical leap found the medical community and society unprepared to deal with the scientific, ethical, and societal implications of a surgical procedure that was striving to transition from sci-fi novels to science. Today, 10 years and over 35 transplants later, public opinion has become accustomed to the concept of "face restoration" through transplantation...
April 26, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28031371/screening-for-novel-small-molecule-inhibitors-targeting-the-assembling-of-influenza-virus-polymerase-complex-by-a-bilc-based-reporter-system
#9
Chunfeng Li, Zining Wang, Yang Cao, Lulan Wang, Jingyun Ji, Zhigao Chen, Tao Deng, Taijiao Jiang, Genhong Cheng, F Xiao-Feng Qin
: Influenza virus RNA-dependent RNA polymerase consists of three viral protein subunits: PA, PB1 and PB2. Protein-protein interactions (PPIs) of these subunits play pivotal roles in assembling the functional polymerase complex, which is essential for the replication and transcription of influenza virus RNA. Here we developed a highly specific and robust bimolecular luminescence complementation (BiLC) reporter system to facilitate the investigation for influenza virus polymerase complex formation...
December 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/28026083/new-oral-targeted-therapies-for-metastatic-breast-cancer-disrupt-the-traditional-patients-management-a-healthcare-providers-view
#10
E Martin, L Pourtau, M Di Palma, S Delaloge
Although a cure still cannot be expected for metastatic breast cancer, thanks to progressive advances in treatments, life expectancy has been increasing over the past 15 years. This study aims to present the impact on the organisation of patients' management of newly released oral targeted therapies dedicated to metastatic breast cancer and the obstacles to their diffusion. Our work is based on the analysis of 40 semi-structured interviews, conducted with oncology healthcare professionals in three regions of France (2015-2016)...
December 27, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27995611/disruptive-potential-of-the-internet-to-transform-illicit-drug-markets-and-impact-on-future-patterns-of-drug-consumption
#11
P Griffiths, J Mounteney
The internet facilitates rapid and covert communication, knowledge transfer, and has the potential to disrupt and transform drug market models and associated consumption patterns. Innovation and new trends diffuse rapidly through this medium and new operational models are emerging. Although the online drug markets currently only account for a small share of all drug transactions, the potential of the surface and deep web to provide a new platform for drug sale and exchanges is considerable.
November 7, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27993335/the-oregon-model-of-behavior-family-therapy-from-intervention-design-to-promoting-large-scale-system-change
#12
Thomas Dishion, Marion Forgatch, Patricia Chamberlain, William E Pelham
This paper reviews the evolution of the Oregon model of family behavior therapy over the past four decades. Inspired by basic research on family interaction and innovation in behavior change theory, a set of intervention strategies were developed that were effective for reducing multiple forms of problem behavior in children (e.g., Patterson, Chamberlain, & Reid, 1982). Over the ensuing decades, the behavior family therapy principles were applied and adapted to promote children's adjustment to address family formation and adaptation (Family Check-Up model), family disruption and maladaptation (Parent Management Training-Oregon model), and family attenuation and dissolution (Treatment Foster Care-Oregon model)...
November 2016: Behavior Therapy
https://www.readbyqxmd.com/read/27977906/new-insights-into-the-effects-of-biomaterial-chemistry-and-topography-on-the-morphology-of-kidney-epithelial-cells
#13
Frits Hulshof, Carolien Schophuizen, Milos Mihajlovic, Clemens van Blitterswijk, Rosalinde Masereeuw, Jan de Boer, Dimitrios Stamatialis
Increasing incidence of renal pathology in the western world calls for innovative research for the development of cell-based therapies such as a Bio-artificial kidney (BAK) device. To fulfill the multitude of kidney functions, the core component of the BAK is a "living membrane" consisting of a tight kidney cell monolayer with preserved functional organic ion transporters cultured on a polymeric membrane surface. This membrane, on one side, is in contact with blood and therefore there should have excellent blood compatibility whereas on the other side should facilitate functional monolayer formation...
December 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27977655/financing-the-canterbury-health-system-post-disaster
#14
Matthew Reid, Ramon Pink
The Canterbury Health System has invested substantially in its transformation to a patient-centred, integrated system, enabling improved performance despite the significant and long-term impacts of the Christchurch earthquakes in 2010 and 2011. Questions have been raised about whether this transformation is sustainable and affordable. We argue that there is a need for a post-disaster health funding strategy that takes into account the challenge of following population movements after a large natural disaster, and higher costs resulting from the disruption and the effect on the population...
December 16, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27977002/supporting-heart-failure-patient-transitions-from-acute-to-community-care-with-home-telemonitoring-technology-a-protocol-for-a-provincial-randomized-controlled-trial-tec4home
#15
(no author information available yet)
BACKGROUND: Seniors with chronic diseases such as heart failure have complex care needs. They are vulnerable to their condition deteriorating and, without timely intervention, may require multiple emergency department visits and/or repeated hospitalizations. Upon discharge, the transition from the emergency department to home can be a vulnerable time for recovering patients with disruptions in the continuity of care. Remote monitoring of heart failure patients using home telemonitoring, coupled with clear communication protocols between health care professionals, can be effective in increasing the safety and quality of care for seniors with heart failure discharged from the emergency department...
December 18, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27960536/oxidative-stress-induced-mir-200c-disrupts-the-regulatory-loop-among-sirt1-foxo1-and-enos
#16
Fabrizio Carlomosti, Marco D'Agostino, Sara Beji, Alessio Torcinaro, Roberto Rizzi, Germana Zaccagnini, Biagina Maimone, Valeria Di Stefano, Francesca De Santa, Sonia Cordisco, Annalisa Antonini, Roberta Ciarapica, Elena Dellambra, Fabio Martelli, Daniele Avitabile, Maurizio Colognesi Capogrossi, Alessandra Magenta
AIMS: Reactive oxygen species (ROS) play a pivotal role in different pathologic conditions, including ischemia, diabetes, and aging. We previously showed that ROS enhance miR-200c expression, causing endothelial cell (EC) apoptosis and senescence. Herein, we dissect the interaction among miR-200c and three strictly related proteins that modulate EC function and ROS production: sirtuin 1 (SIRT1), endothelial nitric oxide synthase (eNOS), and forkhead box O1 (FOXO1). Moreover, the role of miR-200c on ROS modulation was also investigated...
January 19, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27930094/cancer-stem-cell-hypothesis-for-therapeutic-innovation-in-clinical-oncology-taking-the-root-out-not-chopping-the-leaf
#17
Kevin Dzobo, Dimakatso Alice Senthebane, Arielle Rowe, Nicholas Ekow Thomford, Lamech M Mwapagha, Nasir Al-Awwad, Collet Dandara, M Iqbal Parker
Clinical oncology is in need of therapeutic innovation. New hypotheses and concepts for translation of basic research to novel diagnostics and therapeutics are called for. In this context, the cancer stem cell (CSC) hypothesis rests on the premise that tumors comprise tumor cells and a subset of tumor-initiating cells, CSCs, in a quiescent state characterized by slow cell cycling and expression of specific stem cell surface markers with the capability to maintain a tumor in vivo. The CSCs have unlimited self-renewal abilities and propagate tumors through division into asymmetric daughter cells...
December 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27929324/hither-and-thither-how-do-we-innovate
#18
Robert G Frank
The Dembo-Wright Lecture provided a forum to discuss how innovation occurs in general and in rehabilitation psychology. The 21st Century will rely upon the creation and enhancement of knowledge. Universities, industries and professional disciplines are challenged to develop models that nurture their development of knowledge jobs that create new systems or products. A new model of nurturing innovation: The Rainforest, relies upon creating ecosystems that bring together and support the critical groups allowing instances that propel spontaneous growth of sustainable enterprises...
December 8, 2016: Rehabilitation Psychology
https://www.readbyqxmd.com/read/27925142/dg-connect-funded-projects-on-information-and-communication-technologies-ict-for-old-age-people-beyond-silos-carewell-and-smartcare
#19
W Keijser, E de Manuel-Keenoy, M d'Angelantonio, P Stafylas, P Hobson, G Apuzzo, M Hurtado, J Oates, J Bousquet, A Senn
Information and communication technologies (ICT) are promising for the long-term care of older and frequently frail people. These innovations can improve health outcomes, quality of life and efficiency of care processes, while supporting independent living. However, they may be disruptive innovations. As all European member states are facing an increasing complexity of health and social care, good practices in ICT should be identified and evaluated. Three projects funded by DG CNECT are related to Active and Healthy Ageing (AHA) and frailty: (i) BeyondSilos, dealing with independent living and integrated services, (ii) CareWell, providing integrated care coordination, patient empowerment and home support and (iii) SmartCare, proposing a common set of standard functional specifications for an ICT platform enabling the delivery of integrated care to older patients...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27908788/time-to-wake-up-studying-neurovascular-coupling-and-brain-wide-circuit-function-in-the-un-anesthetized-animal
#20
REVIEW
Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T Winder, Zhifeng Liang, Lilith Antinori, Patrick J Drew, Nanyin Zhang
Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-based and resting-state brain dynamics in humans by inferring neural activity from blood-oxygenation-level dependent (BOLD) signal changes. An accurate interpretation of the hemodynamic changes that underlie fMRI signals depends on the understanding of the quantitative relationship between changes in neural activity and changes in cerebral blood flow, oxygenation and volume. While there has been extensive study of neurovascular coupling in anesthetized animal models, anesthesia causes large disruptions of brain metabolism, neural responsiveness and cardiovascular function...
November 28, 2016: NeuroImage
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