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Disruptive innovation

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https://www.readbyqxmd.com/read/28199820/a-cycles-breaking-framework-to-disrupt-intergenerational-patterns-of-maltreatment-and-vulnerability-during-the-childbearing-year
#1
Mickey Sperlich, Julia Seng, Healther Rowe, Jane Fisher, Chris Cutherbert, Julie Taylor
We propose a cycles-breaking conceptual framework to guide perinatal research, interventions, and clinical innovations that can prevent or disrupt intergenerational cycles of childhood maltreatment and psychiatric vulnerability. The framework is grounded in literature, clinical observations, team science collaboration, and empirical research from numerous disciplines and is specific to the childbearing year. Adoption of the framework has the potential to speed the progress of research on the social problems of intergenerational childhood maltreatment and psychiatric vulnerability...
February 12, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28194769/precision-medicine-nobody-is-average
#2
EDITORIAL
A A Vinks
Medicine gets personal and tailor-made treatments are underway. Hospitals have started to advertise their advanced genomic testing capabilities and even their disruptive technologies to help foster a culture of innovation. The prediction in the lay press is that in decades from now we may look back and see 2017 as the year precision medicine blossomed. It is all part of the Precision Medicine Initiative that takes into account individual differences in people's genes, environments, and lifestyles.
March 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28185958/characterisation-of-aggregates-of-cyclodextrin-drug-complexes-using-taylor-dispersion-analysis
#3
Hadar Zaman, Andrew G Bright, Kevin Adams, David M Goodall, Robert T Forbes
There is a need to understand the nature of aggregation of cyclodextrins (CDs) with guest molecules in increasingly complex formulation systems. To this end an innovative application of Taylor dispersion analysis (TDA) and comparison with dynamic light scattering (DLS) have been carried out to probe the nature of ICT01-2588 (ICT-2588), a novel tumor-targeted vascular disrupting agent, in solvents including a potential buffered formulation containing 10% hydroxypropyl-β-cyclodextrin. The two hydrodynamic sizing techniques give measurement responses are that fundamentally different for aggregated solutions containing the target molecule, and the benefits of using TDA in conjunction with DLS are that systems are characterised through measurement of both mass- and z-average hydrodynamic radii...
February 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28151816/mobile-technology-in-the-perioperative-arena-rapid-evolution-and-future-disruption
#4
Brian S Rothman, Rajnish K Gupta, Matthew D McEvoy
Throughout the history of medicine, physicians have relied upon disruptive innovations and technologies to improve the quality of care delivered, patient outcomes, and patient satisfaction. The implementation of mobile technology in health care is quickly becoming the next disruptive technology. We first review the history of mobile technology over the past 3 decades, discuss the impact of hardware and software, explore the rapid expansion of applications (apps), and evaluate the adoption of mobile technology in health care...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28134280/modulation-of-actin-dynamics-as-potential-macrophage-subtype-targeting-anti-tumour-strategy
#5
Carlo Pergola, Katrin Schubert, Simona Pace, Jana Ziereisen, Felix Nikels, Olga Scherer, Stephan Hüttel, Stefan Zahler, Angelika M Vollmar, Christina Weinigel, Silke Rummler, Rolf Müller, Martin Raasch, Alexander Mosig, Andreas Koeberle, Oliver Werz
Tumour-associated macrophages mainly comprise immunosuppressive M2 phenotypes that promote tumour progression besides anti-tumoural M1 subsets. Selective depletion or reprogramming of M2 may represent an innovative anti-cancer strategy. The actin cytoskeleton is central for cellular homeostasis and is targeted for anti-cancer chemotherapy. Here, we show that targeting G-actin nucleation using chondramide A (ChA) predominantly depletes human M2 while promoting the tumour-suppressive M1 phenotype. ChA reduced the viability of M2, with minor effects on M1, but increased tumour necrosis factor (TNF)α release from M1...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28129853/analysis-of-myelinated-axon-formation-in-zebrafish
#6
M D'Rozario, K R Monk, S C Petersen
Myelin is a lipid-rich sheath formed by the spiral wrapping of specialized glial cells around axon segments. Myelinating glia allow for rapid transmission of nerve impulses and metabolic support of axons, and the absence of or disruption to myelin results in debilitating motor, cognitive, and emotional deficits in humans. Because myelin is a jawed vertebrate innovation, zebrafish are one of the simplest vertebrate model systems to study the genetics and development of myelinating glia. The morphogenetic cellular movements and genetic program that drive myelination are conserved between zebrafish and mammals, and myelin develops rapidly in zebrafish larvae, within 3-5days postfertilization...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28103489/enhanced-degradation-of-organic-contaminants-in-water-by-peroxydisulfate-coupled-with-bisulfite
#7
Chengdu Qi, Xitao Liu, Yang Li, Chunye Lin, Jun Ma, Xiaowan Li, Huijuan Zhang
In this study, the bisulfite-peroxydisulfate system (S(IV)/PDS) widely used in polymerization was innovatively applied for organic contaminants degradation in water. The addition of S(IV) into PDS system remarkably enhanced the degradation efficiency of bisphenol A (BPA, a frequently detected endocrine disrupting chemical in the environments) from 17.0% to 84.7% within 360 min. The degradation efficiency of BPA in the S(IV)/PDS system followed pseudo-first-order kinetics, with rate constant values ranging from 0...
January 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28102908/addressing-critical-gaps-in-the-treatment-of-eating-disorders
#8
REVIEW
Alan E Kazdin, Ellen E Fitzsimmons-Craft, Denise E Wilfley
Remarkable progress has been made in developing psychosocial interventions for eating disorders and other mental disorders. Two priorities in providing treatment consist of addressing the research-practice gap and the treatment gap. The research-practice gap pertains to the dissemination of evidence-based treatments from controlled settings to routine clinical care. Closing the gap between what is known about effective treatment and what is actually provided to patients who receive care is crucial in improving mental health care, particularly for conditions such as eating disorders...
January 19, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28090510/augmented-and-virtual-reality-in-surgery-the-digital-surgical-environment-applications-limitations-and-legal-pitfalls
#9
REVIEW
Wee Sim Khor, Benjamin Baker, Kavit Amin, Adrian Chan, Ketan Patel, Jason Wong
The continuing enhancement of the surgical environment in the digital age has led to a number of innovations being highlighted as potential disruptive technologies in the surgical workplace. Augmented reality (AR) and virtual reality (VR) are rapidly becoming increasingly available, accessible and importantly affordable, hence their application into healthcare to enhance the medical use of data is certain. Whether it relates to anatomy, intraoperative surgery, or post-operative rehabilitation, applications are already being investigated for their role in the surgeons armamentarium...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28089207/delivery-dilemmas-how-drug-cryptomarket-users-identify-and-seek-to-reduce-their-risk-of-detection-by-law-enforcement
#10
Judith Aldridge, Rebecca Askew
BACKGROUND: Cryptomarkets represent an important drug market innovation by bringing buyers and sellers of illegal drugs together in a 'hidden' yet public online marketplace. We ask: How do cryptomarket drug sellers and buyers perceive the risks of detection and arrest, and attempt to limit them? METHODS: We analyse selected texts produced by vendors operating on the first major drug cryptomarket, Silk Road (N=600) alongside data extracted from the marketplace discussion forum that include buyer perspectives...
January 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28072752/a-simpler-blood-test-for-monitoring-kidney-transplant-recipients-a-disrupting-innovation
#11
Christine M Wu, Sundaram Hariharan
No abstract text is available yet for this article.
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28071841/attending-to-power-differentials-how-np-led-group-medical-visits-can-influence-the-management-of-chronic-conditions
#12
Laura Housden, Annette J Browne, Sabrina T Wong, Martin Dawes
OBJECTIVE: In Canada, primary care reform has encouraged innovations, including nurse practitioners (NPs) and group medical visits (GMVs). NP-led GMVs provide an opportunity to examine barriers and enablers to implementing this innovation in primary care. DESIGN: An instrumental case study design (n=3): two cases where NPs were using GMVs and one case where NPs were not using GMVs, was completed. In-depth interviews with patients and providers (N=24) and 10 hours of direct observation were completed...
January 10, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28045038/disruption-of-cell-adhesion-by-an-antibody-targeting-the-cell-adhesive-intermediate-x-dimer-of-human-p-cadherin
#13
Shota Kudo, Jose M M Caaveiro, Satoru Nagatoishi, Takamitsu Miyafusa, Tadashi Matsuura, Yukio Sudou, Kouhei Tsumoto
Human P-cadherin is a cell adhesion protein of the family of classical cadherins, the overexpression of which is correlated with poor prognosis in various types of cancer. Antibodies inhibiting cell-cell adhesion mediated by P-cadherin show clear therapeutic effect, although the mechanistic basis explaining their effectiveness is still unclear. Based on structural, physicochemical, and functional analyses, we have elucidated the molecular mechanism of disruption of cell adhesion by antibodies targeting human P-cadherin...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28032849/reflections-on-a-decade-of-face-transplantation
#14
Giorgio Giatsidis, Indranil Sinha, Bohdan Pomahac
On November 27, 2005, Isabelle Dinoire underwent the world's first partial face transplant in Amiens (France) after a dog attack had left her face severely disfigured. The abrupt surgical leap found the medical community and society unprepared to deal with the scientific, ethical, and societal implications of a surgical procedure that was striving to transition from sci-fi novels to science. Today, 10 years and over 35 transplants later, public opinion has become accustomed to the concept of "face restoration" through transplantation...
April 26, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28031371/screening-for-novel-small-molecule-inhibitors-targeting-the-assembling-of-influenza-virus-polymerase-complex-by-a-bilc-based-reporter-system
#15
Chunfeng Li, Zining Wang, Yang Cao, Lulan Wang, Jingyun Ji, Zhigao Chen, Tao Deng, Taijiao Jiang, Genhong Cheng, F Xiao-Feng Qin
: Influenza virus RNA-dependent RNA polymerase consists of three viral protein subunits: PA, PB1 and PB2. Protein-protein interactions (PPIs) of these subunits play pivotal roles in assembling the functional polymerase complex, which is essential for the replication and transcription of influenza virus RNA. Here we developed a highly specific and robust bimolecular luminescence complementation (BiLC) reporter system to facilitate the investigation for influenza virus polymerase complex formation...
December 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/28026083/new-oral-targeted-therapies-for-metastatic-breast-cancer-disrupt-the-traditional-patients-management-a-healthcare-providers-view
#16
E Martin, L Pourtau, M Di Palma, S Delaloge
Although a cure still cannot be expected for metastatic breast cancer, thanks to progressive advances in treatments, life expectancy has been increasing over the past 15 years. This study aims to present the impact on the organisation of patients' management of newly released oral targeted therapies dedicated to metastatic breast cancer and the obstacles to their diffusion. Our work is based on the analysis of 40 semi-structured interviews, conducted with oncology healthcare professionals in three regions of France (2015-2016)...
December 27, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27995611/disruptive-potential-of-the-internet-to-transform-illicit-drug-markets-and-impact-on-future-patterns-of-drug-consumption
#17
P Griffiths, J Mounteney
The internet facilitates rapid and covert communication, knowledge transfer, and has the potential to disrupt and transform drug market models and associated consumption patterns. Innovation and new trends diffuse rapidly through this medium and new operational models are emerging. Although the online drug markets currently only account for a small share of all drug transactions, the potential of the surface and deep web to provide a new platform for drug sale and exchanges is considerable.
November 7, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27993335/the-oregon-model-of-behavior-family-therapy-from-intervention-design-to-promoting-large-scale-system-change
#18
Thomas Dishion, Marion Forgatch, Patricia Chamberlain, William E Pelham
This paper reviews the evolution of the Oregon model of family behavior therapy over the past four decades. Inspired by basic research on family interaction and innovation in behavior change theory, a set of intervention strategies were developed that were effective for reducing multiple forms of problem behavior in children (e.g., Patterson, Chamberlain, & Reid, 1982). Over the ensuing decades, the behavior family therapy principles were applied and adapted to promote children's adjustment to address family formation and adaptation (Family Check-Up model), family disruption and maladaptation (Parent Management Training-Oregon model), and family attenuation and dissolution (Treatment Foster Care-Oregon model)...
November 2016: Behavior Therapy
https://www.readbyqxmd.com/read/27977906/new-insights-into-the-effects-of-biomaterial-chemistry-and-topography-on-the-morphology-of-kidney-epithelial-cells
#19
Frits Hulshof, Carolien Schophuizen, Milos Mihajlovic, Clemens van Blitterswijk, Rosalinde Masereeuw, Jan de Boer, Dimitrios Stamatialis
Increasing incidence of renal pathology in the western world calls for innovative research for the development of cell-based therapies such as a Bio-artificial kidney (BAK) device. To fulfill the multitude of kidney functions, the core component of the BAK is a "living membrane" consisting of a tight kidney cell monolayer with preserved functional organic ion transporters cultured on a polymeric membrane surface. This membrane, on one side, is in contact with blood and therefore there should have excellent blood compatibility whereas on the other side should facilitate functional monolayer formation...
December 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27977655/financing-the-canterbury-health-system-post-disaster
#20
Matthew Reid, Ramon Pink
The Canterbury Health System has invested substantially in its transformation to a patient-centred, integrated system, enabling improved performance despite the significant and long-term impacts of the Christchurch earthquakes in 2010 and 2011. Questions have been raised about whether this transformation is sustainable and affordable. We argue that there is a need for a post-disaster health funding strategy that takes into account the challenge of following population movements after a large natural disaster, and higher costs resulting from the disruption and the effect on the population...
December 16, 2016: New Zealand Medical Journal
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