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Disruptive innovation

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https://www.readbyqxmd.com/read/28729843/is-a-transdisciplinary-theory-of-engagement-in-organized-settings-possible-a-concept-analysis-of-the-literature-on-employee-engagement-consumer-engagement-and-patient-engagement
#1
REVIEW
Guendalina Graffigna
Organizations are experiencing increased competition, disruptive innovation, and continuous changes in their social and economic context. Furthermore, the decrease of resources (economic and human) in such a demanding context make it imperative for organizations to find new models and strategies to make their service delivery more sustainable at the economic, environmental and psychological levels. In such a complex scenario the concept of engagement of the individuals involved in organized settings (either as service providers or as final receivers) is a promising lever for innovation...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28726632/dynamics-of-genomic-innovation-in-the-unicellular-ancestry-of-animals
#2
Xavier Grau-Bové, Guifré Torruella, Stuart Donachie, Hiroshi Suga, Guy Leonard, Thomas A Richards, Iñaki Ruiz-Trillo
Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the emergence of animal-like traits. Our comparative analysis involves genomes from animals and their closest unicellular relatives (the Holozoa), including four new genomes: three Ichthyosporea and Corallochytrium limacisporum. Here we show that the earliest animals were shaped by dynamic changes in genome architecture before the emergence of multicellularity: an early burst of gene diversity in the ancestor of Holozoa, enriched in transcription factors and cell adhesion machinery, was followed by multiple and differently-timed episodes of synteny disruption, intron gain and genome expansions...
July 20, 2017: ELife
https://www.readbyqxmd.com/read/28723841/military-civilian-partnership-in-device-innovation-development-commercialization-and-application-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa
#3
Todd E Rasmussen, Jonathan L Eliason
Noncompressible torso hemorrhage (NCTH) and shock is a leading cause of trauma-related mortality and evidence suggests that survival from this injury pattern has not improved in decades. As such, innovating new approaches and devices, including technologies which can be used by providers within a short of time after severe injury, is a priority for the military. Guided by wartime observations, and through partnerships with civilian academia and private investment, the military has led an effort to define resuscitative endovascular balloon occlusion of the aorta (REBOA) and assess its potential to address this problem...
July 19, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28719285/trial-of-a-novel-intervention-to-improve-multiple-food-hygiene-behaviors-in-nepal
#4
Om Prasad Gautam, Wolf-Peter Schmidt, Sandy Cairncross, Sue Cavill, Valerie Curtis
AbstractIn this study, we report on the results of a trial of an intervention to improve five food hygiene behaviors among mothers of young children in rural Nepal. This novel intervention targeted five behaviors; cleanliness of serving utensils, handwashing with soap before feeding, proper storage of cooked food, and thorough reheating and water treatment. Based on formative research and a creative process using the Behavior-Centered Design approach, an innovative intervention package was designed and delivered over a period of 3 months...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718903/affairs-of-the-heart-innovation-in-cardiovascular-research-and-development
#5
EDITORIAL
P Honig, A Terzic
Cardiovascular disease represents the single largest contributor to morbidity and mortality, yet the flow of therapeutic innovation is lagging. Globally, academia, industry, and regulatory agencies must work together to address this gap, and ensure new disruptive therapeutic modalities to address growing needs of patients and society.
August 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28708957/influenza-vaccination-in-the-elderly
#6
Smetana Jan, Chlibek Roman, Shaw Jana, Splino Miroslav, Prymula Roman
Seasonal influenza is a prevalent and serious annual illness resulting in widespread morbidity and economic disruption throughout the population; the elderly and immunocompromised are particularly vulnerable to serious sequelae and mortality. The changing demographics worldwide to an aging society have important implications for public health policy and pharmaceutical innovations. For instance, primary prevention via immunization is effective in reducing the burden of influenza illness among the elderly. However, the elderly may be insufficiently protected by vaccination due to the immunosenescence which accompanies aging...
July 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28699060/assessing-the-burden-of-treatment
#7
Gabriela Spencer-Bonilla, Ana R Quiñones, Victor M Montori
Current healthcare systems and guidelines are not designed to adapt to care for the large and growing number of patients with complex care needs and those with multimorbidity. Minimally disruptive medicine (MDM) is an approach to providing care for complex patients that advances patients' goals in health and life while minimizing the burden of treatment. Measures of treatment burden assess the impact of healthcare workload on patient function and well-being. At least two of these measures are now available for use with patients living with chronic conditions...
July 11, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28679874/find-your-passion-lead-with-purpose-a-health-informaticians-guide
#8
Mowafa Househ
Health Informatics is an ever evolving, changing and dynamic field that has become the disruptive innovation shaping the future of healthcare. Health informaticians face a number of challenges in the workplace such as gaining acceptance and recognition from other healthcare providers and overcoming the resistance of healthcare providers from using technology in clinical practice. Being a health informatician is not for the faint hearted, especially as resistance to the role of health informaticians continues from both healthcare providers and hospital administrators...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28675194/aortic-stenosis-pathogenesis-prediction-of-progression-and-percutaneous-intervention
#9
D Natarajan, B Prendergast
Aortic stenosis is common and an important cause of morbidity and mortality. Prevalence will increase significantly in forthcoming decades as a function of the ageing population; treatment by means of surgery or percutaneous intervention is expensive. Epidemiological, mechanistic and interventional studies are therefore vital to determine optimal and innovative treatments and their funding. Recent studies suggest that aortic stenosis is not a passive degenerative disease, but an active process involving several pathways, including lipid infiltration, chronic inflammation, fibrosis formation, osteoblast activation, and active valve mineralisation...
June 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28673651/needs-based-innovation-in-interventional-radiology-the-biodesign-process
#10
Jonathan D Steinberger, Lyn Denend, Dan E Azagury, Todd J Brinton, Josh Makower, Paul G Yock
There are many possible mechanisms for innovation and bringing new technology into the marketplace. The Stanford Biodesign innovation process is based in a deep understanding of clinical unmet needs as the basis for focused ideation and development. By identifying and vetting a compelling unmet need, the aspiring innovator can "derisk" a project and maximize chances for successful development in an increasingly challenging regulatory and economic environment. As a specialty founded by tinkerers, with a history of disruptive innovation that has yielded countless new ways of delivering care with minimal invasiveness, lower morbidity, and lower cost, interventional radiologists are uniquely well positioned to identify unmet needs and develop novel solutions free of dogmatic convention...
June 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/28670100/the-assets-based-approach-furthering-a-neoliberal-agenda-or-rediscovering-the-old-public-health-a-critical-examination-of-practitioner-discourses
#11
Michael J Roy
The 'assets-based approach' to health and well-being has, on the one hand, been presented as a potentially empowering means to address the social determinants of health while, on the other, been criticised for obscuring structural drivers of inequality and encouraging individualisation and marketisation; in essence, for being a tool of neoliberalism. This study looks at how this apparent contestation plays out in practice through a critical realist-inspired examination of practitioner discourses, specifically of those working within communities to address social vulnerabilities that we know impact upon health...
August 8, 2017: Critical Public Health
https://www.readbyqxmd.com/read/28666558/systematic-review-of-emerging-and-innovative-technologies-for-meat-tenderisation
#12
R D Warner, C K McDonnell, A E D Bekhit, J Claus, R Vaskoska, A Sikes, F R Dunshea, M Ha
Consumers are the final step in the meat supply chain and meeting consumer expectations of quality and tenderness are important for satisfaction and repeat purchase. High pressure processing, shockwaves, ultrasound, pulsed electric field and muscle stretching can be applied to pre- and post-rigor meat for tenderisation. These non-thermal and thermal innovative technologies can be used with varying levels of success to cause physical disruption to muscle structure, enhanced proteolysis and ageing and muscle protein denaturation and solubilisation resulting in changes to texture and juiciness...
May 3, 2017: Meat Science
https://www.readbyqxmd.com/read/28666191/exploring-the-cycloheptathiophene-3-carboxamide-scaffold-to-disrupt-the-interactions-of-the-influenza-polymerase-subunits-and-obtain-potent-anti-influenza-activity
#13
Jenny Desantis, Giulio Nannetti, Serena Massari, Maria Letizia Barreca, Giuseppe Manfroni, Violetta Cecchetti, Giorgio Palù, Laura Goracci, Arianna Loregian, Oriana Tabarrini
With the aim to identify small molecules able to disrupt PA-PB1 subunits interaction of influenza virus (flu) RNA-dependent RNA polymerase, and based on previous structural and computational information, in this paper we have designed and synthesized a new series of cycloheptathiophene-3-carboxamide (cHTC) derivatives. Their biological evaluation led to highlight important structural insights along with new interesting compounds, such as the 2-hydroxybenzamido derivatives 29, 31, and 32, and the 4-aminophenyl derivative 54, which inhibited viral growth in the low micromolar range (EC50 = 0...
June 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28659447/unravelling-the-relationship-between-the-tsetse-fly-and-its-obligate-symbiont-wigglesworthia-transcriptomic-and-metabolomic-landscapes-reveal-highly-integrated-physiological-networks
#14
XiaoLi Bing, Geoffrey M Attardo, Aurelien Vigneron, Emre Aksoy, Francesca Scolari, Anna Malacrida, Brian L Weiss, Serap Aksoy
Insects with restricted diets rely on obligate microbes to fulfil nutritional requirements essential for biological function. Tsetse flies, vectors of African trypanosome parasites, feed exclusively on vertebrate blood and harbour the obligate endosymbiont Wigglesworthia glossinidia. Without Wigglesworthia, tsetse are unable to reproduce. These symbionts are sheltered within specialized cells (bacteriocytes) that form the midgut-associated bacteriome organ. To decipher the core functions of this symbiosis essential for tsetse's survival, we performed dual-RNA-seq analysis of the bacteriome, coupled with metabolomic analysis of bacteriome and haemolymph collected from normal and symbiont-cured (sterile) females...
June 28, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28646974/testing-the-feasibility-of-a-briefer-school-based-preventive-intervention-with-aggressive-children-a-hybrid-intervention-with-face-to-face-and-internet-components
#15
John E Lochman, Caroline L Boxmeyer, Shannon Jones, Lixin Qu, David Ewoldsen, W Michael Nelson
This study describes the results from a feasibility study of an innovative indicated prevention intervention with hybrid face-to-face and web-based components for preadolescent youth. This intervention includes a considerably briefer set of face-to-face sessions from the evidence-based Coping Power program and a carefully integrated internet component with practice and teaching activities and cartoon videos for children and for parents. The Coping Power - Internet Enhanced (CP-IE) program introduces a set of cognitive-behavioral skills in 12 small group sessions for children delivered during the school day and 7 group sessions for parents...
June 2017: Journal of School Psychology
https://www.readbyqxmd.com/read/28646446/innovations-in-the-endovascular-management-of-critical-limb-ischemia-retrograde-tibiopedal-access-and-advanced-percutaneous-techniques
#16
REVIEW
Jihad A Mustapha, Larry J Diaz-Sandoval, Fadi Saab
PURPOSE OF REVIEW: Retrograde tibiopedal access and interventions have contributed to advance of endovascular techniques to treat critical limb ischemia (CLI) patients. This review encompasses the spectrum from advanced diagnostic imaging and technical therapeutic approaches for infrapopliteal occlusions, to a discussion of current standards and future directions. RECENT FINDINGS: Contemporary studies of infrapopliteal angioplasty show suboptimal short-term and 1-year clinical outcomes...
August 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28638512/an-early-assessment-of-the-acgme-cler-program-a-national-survey-of-designated-institutional-officials
#17
Timothy R Long, Julie A Doherty, Katrin R Frimannsdottir, Steven H Rose
BACKGROUND: The Accreditation Council for Graduate Medical Education (ACGME) Clinical Learning Environment Review (CLER) is an innovative element of the ACGME's new accreditation system. To date, little information has been collected regarding the value of CLER. OBJECTIVE: The purpose of this study is to collect information on designated institutional officials' (DIOs') perspectives about the initial CLER visits conducted at their institutions. METHODS: The authors created and distributed a survey to DIOs about their initial CLER visits...
June 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28631058/expression-and-characterization-of-glucose-oxidase-from-aspergillus-niger-in-yarrowia-lipolytica
#18
Fatemeh Khadivi Derakshan, Farshad Darvishi, Mehrouz Dezfulian, Catherine Madzak
Glucose oxidase (GOX) is currently used in clinical, pharmaceutical, food and chemical industries. The aim of this study was expression and characterization of Aspergillus niger glucose oxidase gene in the yeast Yarrowia lipolytica. For the first time, the GOX gene of A. niger was successfully expressed in Y. lipolytica using a mono-integrative vector containing strong hybrid promoter and secretion signal. The highest total glucose oxidase activity was 370 U/L after 7 days of cultivation. An innovative method was used to cell wall disruption in current study, and it could be recommended to use for efficiently cell wall disruption of Y...
August 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28626514/where-are-drugs-invented-and-why-does-it-matter
#19
EDITORIAL
Yali Friedman
Globalization has disrupted many industries, initially shifting unskilled labor employment from high wage-cost industrialized nations to lower wage-cost emerging economies. There has been a trend toward moving increasingly skilled work away from industrialized nations, which raises the question-has innovative research and development been affected by globalization, and why is relocation of innovation much more than a simple economic concern?
June 8, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28618841/assessment-of-solid-microneedle-rollers-to-enhance-transmembrane-delivery-of-doxycycline-and-inhibition-of-mmp-activity
#20
Abbie Omolu, Maryse Bailly, Richard M Day
Many chronic wounds exhibit high matrix metalloproteinase (MMP) activity that impedes the normal wound healing process. Intradermal delivery (IDD) of sub-antimicrobial concentrations of doxycycline, as an MMP inhibitor, could target early stages of chronic wound development and inhibit further wound progression. To deliver doxycycline intradermally, the skin barrier must be disrupted. Microneedle rollers offer a minimally invasive technique to penetrate the skin by creating multiple microchannels that act as temporary conduits for drugs to diffuse through...
November 2017: Drug Delivery
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