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https://www.readbyqxmd.com/read/29141402/-epidemiology-of-the-carbapenemase-producing-enterobacteriaceae-spread-in-a-community-acute-hospital-and-a-non-acute-rehabilitation-hospital-in-madrid
#1
M López-Dosil, C Bischofberge, D Sáez, C García-Picazo
OBJECTIVE: In Spain, the overall prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is increasing. We describe the epidemiological, clinical and microbiological characteristics features of patients with colonization or infection due to CRE in two hospitals in the north-west of Madrid during two years. One hospital was a community acute hospital and the second one was a non-acute rehabilitation hospital. METHODS: A total of 197 CPE isolates were detected during 2013-2014...
November 14, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29141380/-the-analysis-of-anesthetic-management-for-renal-cell-carcinoma-with-associated-inferior-vena-cava-tumor-thrombus
#2
H Zeng, X Y Rong, Y Wang, X Y Guo
Objective: To explore the key points of anesthetic management for renal cell carcinoma combined with inferior vena cava (IVC) tumor thrombus. Methods: Twenty-seven cases of renal cell carcinoma with inferior vena cava (IVC) tumor thrombus underwent radical nephrectomy and inferior caval venous thrombectomy were reviewed retrospectively during January 2014 to January 2017 in our hospital.Analyzed data includs demographics, classification of tumor, perioperative anesthetic management and monitoring approaches, IVC clamping time , vital signs during cardiopulmonary bypass(CPB), estimated blood loss (EBL), usage of blood products, hospitalization time and ICU time , as well as postoperative outcomes...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29141289/-a-retrospective-study-on-the-assessment-of-dysphagia-after-partial-laryngectomy
#3
T T Su, Z F Sun
Objective: To retrospectively investigate the long-term swallowing function of patients with laryngeal carcinoma, who underwent partial laryngectomy, discuss the effectiveness and reliability of Kubota drinking test in the assessment of patients with dysphagia, who underwent partial laryngectomy, and analyze the influence of different ways of operation on swallowing function. Methods: Clinical data were retrospectively analyzed on 83 patients with laryngeal carcinoma, who underwent partial laryngectomy between September 2012 and August 2015...
November 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29141255/is-venlafaxine-more-effective-than-escitalopram-and-nortriptyline-in-the-management-of-painful-symptoms-in-patients-with-major-depression
#4
Jan Jaracz, Karolina Gattner, Krystyna Jaracz, Krystyna Górna, Jerzy Moczko, Joanna Hauser
Background Conflicting data regarding the efficacy of antidepressants of different mechanism of action on unexplained painful physical symptoms (UPPS) in depression have been published so far. Objective The aim of this study was to compare the impact of escitalopram (ESC), nortriptyline (NOR), and venlafaxine (VEN) on UPPS in patients with major depression. Materials and methods Sixty patients, participants in the GENDEP study, with a diagnosis of depression according to the ICD-10 criteria were randomly assigned to treatment with ESC (10-30 mg, mean dose 15...
November 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29141073/forces-of-tool-tissue-interaction-to-assess-surgical-skill-level
#5
Taku Sugiyama, Sanju Lama, Liu Shi Gan, Yaser Maddahi, Kourosh Zareinia, Garnette R Sutherland
Importance: The application of optimal forces between surgical instruments and tissue is fundamental to surgical performance and learning. To date, this force has not been measured clinically during the performance of microsurgery. Objectives: To establish a normative catalog of force profiles during the performance of surgery, to compare force variables among surgeons with different skill levels, and to evaluate whether such a force-based metric determines or differentiates skill level...
November 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29141005/fast-axis-agnostic-dynamically-summarized-storage-and-retrieval-for-mass-spectrometry-data
#6
Kyle Handy, Jebediah Rosen, André Gillan, Rob Smith
Mass spectrometry, a popular technique for elucidating the molecular contents of experimental samples, creates data sets comprised of millions of three-dimensional (m/z, retention time, intensity) data points that correspond to the types and quantities of analyzed molecules. Open and commercial MS data formats are arranged by retention time, creating latency when accessing data across multiple m/z. Existing MS storage and retrieval methods have been developed to overcome the limitations of retention time-based data formats, but do not provide certain features such as dynamic summarization and storage and retrieval of point meta-data (such as signal cluster membership), precluding efficient viewing applications and certain data-processing approaches...
2017: PloS One
https://www.readbyqxmd.com/read/29140977/low-cost-and-open-source-multi-fluorescence-imaging-system-for-teaching-and-research-in-biology-and-bioengineering
#7
Isaac Nuñez, Tamara Matute, Roberto Herrera, Juan Keymer, Timothy Marzullo, Timothy Rudge, Fernán Federici
The advent of easy-to-use open source microcontrollers, off-the-shelf electronics and customizable manufacturing technologies has facilitated the development of inexpensive scientific devices and laboratory equipment. In this study, we describe an imaging system that integrates low-cost and open-source hardware, software and genetic resources. The multi-fluorescence imaging system consists of readily available 470 nm LEDs, a Raspberry Pi camera and a set of filters made with low cost acrylics. This device allows imaging in scales ranging from single colonies to entire plates...
2017: PloS One
https://www.readbyqxmd.com/read/29140941/phenotype-and-management-of-infantile-onset-inflammatory-bowel-disease-experience-from-a-tertiary-care-center-in-china
#8
Ziqing Ye, Ying Zhou, Ying Huang, Yuhuan Wang, Junping Lu, Zifei Tang, Shijian Miao, Kuiran Dong, Zhinong Jiang
BACKGROUND: Infantile-onset inflammatory bowel disease (IBD) comprises rare and clinically severe disorders. We examined the phenotypes and genetic causes of patients with infantile-onset IBD from a tertiary medical center. METHODS: We enrolled 38 patients with infantile-onset IBD and applied standardized treatment with medical, surgical, and supportive care. Targeted sequencing and whole-exome sequencing were performed. Clinical data were retrieved from medical records...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29140774/anal-cancer-risk-among-people-with-hiv-infection-in-the-united-states
#9
Vivian Colón-López, Meredith S Shiels, Mark Machin, Ana P Ortiz, Howard Strickler, Philip E Castle, Ruth M Pfeiffer, Eric A Engels
Purpose People with HIV infection have an elevated risk of anal cancer. However, recent calendar trends are incompletely described, and which population subgroups might benefit from cancer screening is unknown. Methods We used linked data from HIV and cancer registries in nine US areas (1996 to 2012). We calculated standardized incidence ratios to compare anal cancer incidence in people with HIV infection with the general population, used Poisson regression to evaluate anal cancer incidence among subgroups of people with HIV and to assess temporal trends, and estimated the cumulative incidence of anal cancer to measure absolute risk...
November 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29140743/research-ethics-review-for-the-use-of-anonymized-samples-and-data-a-systematic-review-of-normative-documents
#10
Amicia Phillips, Pascal Borry, Mahsa Shabani
While the anonymization of biological samples and data may help protect participant privacy, there is still debate over whether this alone is a sufficient safeguard to ensure the ethical conduct of research. The purpose of this systematic review is to examine whether the review of an ethics committee is necessary in the context of anonymized research, and what the considerations in said ethics review would be. The review of normative documents issued by both national and international level organizations reveals a growing concern over the ability of anonymization procedures to prevent against reidentification...
2017: Accountability in Research
https://www.readbyqxmd.com/read/29140661/an-international-model-for-antibiotics-regulation
#11
Emilie Aguirre
We face a global antibiotics resistance crisis. Antibiotic drugs are rapidly losing their effectiveness, potentially propelling us toward a post-antibiotic world. The largest use of antibiotics in the world is in food-producing animals. Food producers administer these drugs in routine, low doses—the types of doses that are incidentally the most conducive to breeding antibiotic resistance. In general, individual countries have been too slow to act in regulating misuse and overuse of antibiotics in foodproducing animals...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29140617/methods-of-collecting-and-analyzing-rearward-visibility-data-for-agricultural-machinery-hazard-and-or-object-detectability
#12
Shawn G Ehlers, William E Field, Daniel R Ess
Recent interest in rearward visibility for private, construction, and commercial vehicles and documentation of rearward runovers involving bystanders outside the field of vision of the vehicle operator led to an investigation into the need for enhanced methods of rearward visibility for large, off-highway, agricultural equipment. A review of the literature found limited relevant research and minimal data on incidents involving rearward runovers of bystanders and co-workers. This article reviews the findings regarding the methods identified and tested to collect and analyze rearward visibility data, from the operator's perspective, for large self-propelled agricultural equipment, including the four-wheel drive tractors, combines, agricultural sprayers, and skid-steer loaders that are increasingly found on agricultural production sites...
January 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29140584/the-association-between-female-genital-fistula-symptoms-and-gender-based-violence-a-multi-country-secondary-analysis-of-household-survey-data
#13
Lindsay Mallick, Vandana Tripathi
OBJECTIVE: The Demographic and Health Surveys (DHS), which include standardized questions on female genital fistula symptoms, provide a unique opportunity to evaluate the epidemiology of fistula. This study sought to examine associations between self-reported fistula symptoms and experience of gender-based violence (GBV) among women interviewed in DHS surveys. METHODS: This study used data from thirteen DHS surveys with standardized fistula and domestic violence modules...
November 15, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29140549/improving-pancreas-graft-utilization-through-importation
#14
Julia Torabi, Juan P Rocca, Krystina Choinski, Katherine Lorenzen, Camille Yongue, Michelle L Lubetzsky, Melvon E Herbert, Attasit Chokechanachaisakul, Maria Ajaimy, Layla Kamal, Enver Akalin, Milan Kinkhabwala, Jay A Graham
BACKGROUND: We analyze our outcomes utilizing imported allografts as a strategy to shorten wait list time for pancreas transplantation. METHODS: This is an observational retrospective cohort of 26 recipients who received either a locally procured (n=16) or an imported pancreas graft (n=10) at our center between January 2014 and May 2017. Wait list times of this cohort were compared to UNOS Region 9 (New York State and Western Vermont). Hospital financial data was also reviewed to analyze the cost effectiveness of this strategy...
November 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29140537/using-normal-and-high-pulse-coverage-with-picosecond-laser-treatment-of-wrinkles-and-acne-scarring-long-term-clinical-observations
#15
Christine Dierickx
OBJECTIVE: The picosecond 755 nm alexandrite laser using a diffractive lens array has demonstrated consistent clinical efficacy for improving the appearance of acne scarring and wrinkles amongst other benefits. This small pilot study is to assess the difference, if any, in clinical benefit if a higher than the standard protocol for number of pulses delivered to a tissue area is used compared to the standard protocol guidelines. METHOD: Seven subjects received treatment to one side of the face with a standard protocol number of laser pulses with the other side of the face receiving higher than standard number of pulses from the same 755 nm picosecond laser using an additional diffractive lens array...
November 15, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29140462/data-portal-for-the-library-of-integrated-network-based-cellular-signatures-lincs-program-integrated-access-to-diverse-large-scale-cellular-perturbation-response-data
#16
Amar Koleti, Raymond Terryn, Vasileios Stathias, Caty Chung, Daniel J Cooper, John P Turner, Dušica Vidovic, Michele Forlin, Tanya T Kelley, Alessandro D'Urso, Bryce K Allen, Denis Torre, Kathleen M Jagodnik, Lily Wang, Sherry L Jenkins, Christopher Mader, Wen Niu, Mehdi Fazel, Naim Mahi, Marcin Pilarczyk, Nicholas Clark, Behrouz Shamsaei, Jarek Meller, Juozas Vasiliauskas, John Reichard, Mario Medvedovic, Avi Ma'ayan, Ajay Pillai, Stephan C Schürer
The Library of Integrated Network-based Cellular Signatures (LINCS) program is a national consortium funded by the NIH to generate a diverse and extensive reference library of cell-based perturbation-response signatures, along with novel data analytics tools to improve our understanding of human diseases at the systems level. In contrast to other large-scale data generation efforts, LINCS Data and Signature Generation Centers (DSGCs) employ a wide range of assay technologies cataloging diverse cellular responses...
November 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29140435/hmdb-4-0-the-human-metabolome-database-for-2018
#17
David S Wishart, Yannick Djoumbou Feunang, Ana Marcu, An Chi Guo, Kevin Liang, Rosa Vázquez-Fresno, Tanvir Sajed, Daniel Johnson, Carin Li, Naama Karu, Zinat Sayeeda, Elvis Lo, Nazanin Assempour, Mark Berjanskii, Sandeep Singhal, David Arndt, Yonjie Liang, Hasan Badran, Jason Grant, Arnau Serra-Cayuela, Yifeng Liu, Rupa Mandal, Vanessa Neveu, Allison Pon, Craig Knox, Michael Wilson, Claudine Manach, Augustin Scalbert
The Human Metabolome Database or HMDB (www.hmdb.ca) is a web-enabled metabolomic database containing comprehensive information about human metabolites along with their biological roles, physiological concentrations, disease associations, chemical reactions, metabolic pathways, and reference spectra. First described in 2007, the HMDB is now considered the standard metabolomic resource for human metabolic studies. Over the past decade the HMDB has continued to grow and evolve in response to emerging needs for metabolomics researchers and continuing changes in web standards...
November 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29140434/managing-public-health-data-mobile-applications-and-mass-vaccination-campaigns
#18
Melissa W McClung, Sarah A Gumm, Megan E Bisek, Amber L Miller, Bryan C Knepper, Arthur J Davidson
In response to data collection challenges during mass immunization events, Denver Public Health developed a mobile application to support efficient public health immunization and prophylaxis activities. The Handheld Automated Notification for Drugs and Immunizations (HANDI) system has been used since 2012 to capture influenza vaccination data during Denver Health's annual employee influenza campaign. HANDI has supported timely and efficient administration and reporting of influenza vaccinations through standardized data capture and database entry...
November 13, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29140293/the-trends-in-cardiovascular-diseases-and-respiratory-diseases-mortality-in-urban-and-rural-china-1990-2015
#19
Weiwei Sun, Yun Zhou, Zhuang Zhang, Limin Cao, Weihong Chen
With the rapid development of the economy over the past 20 years, the mortality rates from cardiovascular diseases (CVDs) and respiratory diseases (RDs) have changed in China. This study aimed to analyze the trends of mortality rates and years of life lost (YLLs) from CVDs and RDs in the rural and urban population from 1990 to 2015. Using data from Chinese yearbooks, joinpoint regression analysis was employed to estimate the annual percent change (APC) of mortality rates from CVDs and RDs. YLLs due to CVDs and RDs were calculated by a standard method, adopting recommended standard life expectancy at birth values of 80 years for men and 82...
November 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29139314/cost-utility-analysis-of-life-long-prophylaxis-with-recombinant-factor-viii-fc-vs-recombinant-factor-viii-for-the-management-of-severe-haemophilia-a-in-sweden
#20
Nathaniel Henry, Jelena Jovanović, Max Schlueter, Persefoni Kritikou, Koo Wilson, Karl-Johan Myrén
AIMS: Prophylaxis with recombinant factor VIII (rFVIII) is the standard of care for severe haemophilia A in Sweden. The need for frequent injections with existing rFVIII products may, however, result in poor adherence to prophylaxis leading to increased bleeding and long-term joint damage. Recombinant FVIIIFc (rFVIIIFc) is an extended half-life fusion protein which can offer prolonged protection and reduced dosing frequency. The objective of this study was to evaluate the cost-utility of prophylaxis with rFVIIIFc in severe haemophilia A from the perspective of the Swedish health system...
November 15, 2017: Journal of Medical Economics
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