Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Sarut Chaisrisawadisuk, Aekachai Lauvalert, Vannipa Vathanophas, Nachasa Kongchu, Tara Vongviriyangkoon
BACKGROUND: Pierre Robin sequence (PRS), characterized by micrognathia, glossoptosis, cleft palate, and obstructed airways, is one of the craniofacial conditions challenging various approaches to managing compromised airways, ranging from conservative measures to invasive airway surgery. This study was conducted to identify predictive risk factors for tracheostomy in the PRS. METHODS: A retrospective chart review was conducted at a tertiary referral hospital in Thailand...
March 27, 2024: Annals of Plastic Surgery
#2
JOURNAL ARTICLE
Fabio Efficace, Michal Kicinski, Corneel Coens, Stefan Suciu, Walter J F M van der Velden, Richard Noppeney, Sylvain P Chantepie, Laimonas Griskevicius, Andreas Neubauer, Ernesta Audisio, Mario Luppi, Stephan Fuhrmann, Robin Foà, Martina Crysandt, Gianluca Gaidano, Radovan Vrhovac, Adriano Venditti, Eduardus F M Posthuma, Anna Candoni, Frédéric Baron, Olivier Legrand, Andrea Mengarelli, Paola Fazi, Marco Vignetti, Anne Giraut, Pierre W Wijermans, Gerwin A Huls, Michael Lübbert
We hypothesized that fit older patients with acute myeloid leukemia (AML) treated with decitabine (DEC) would report better health-related quality of life (HRQoL) outcomes compared to those receiving intensive chemotherapy (IC). We conducted a phase 3 randomized trial to compare DEC (10-day schedule) to IC (3+7) in older fit AML patients. HRQoL was a secondary endpoint, and it was assessed with the EORTC QLQ-C30 and the QLQ-ELD14. The following scales were a priori selected for defining the primary endpoint: physical and role functioning, fatigue, pain, and burden of illness...
May 8, 2024: Blood
#3
JOURNAL ARTICLE
Sam D Schild, Hari N Magge, Hengameh K Behzadpour, Esperanza Mantilla-Rivas, Nina M Afsar, Md Sohel Rana, Monica Manrique, Albert K Oh, Brian K Reilly
OBJECTIVE: Investigate an association between upper airway obstruction (UAO) management in Robin Sequence (RS) and need for bilateral myringotomy and tubes (BMT). METHODS: Retrospective chart review of RS patients treated at a tertiary free-standing pediatric hospital from 1995 to 2020 was performed. Patients were grouped based on airway management: conservative, tracheostomy, tongue-lip adhesion (TLA), and mandibular distraction osteogenesis (MDO). Demographic data, cleft palate (CP) association, numbers of BMT and ear infections, and audiogram data including tympanograms were collected...
May 4, 2024: International Journal of Pediatric Otorhinolaryngology
#4
JOURNAL ARTICLE
Emily L Mace, Shreyas G Krishnapura, Michael Golinko, James D Phillips, Ryan H Belcher
OBJECTIVE: to investigate the ability of mandibular distraction osteogenesis (MDO) to avoid gastrostomy tube (G-tube). DATA SOURCES: PubMed, EBSCOhost, Cochrane, and Embase. REVIEW METHODS: We retrospectively reviewed the number of MDO cases performed at our institution for patients with Robin Sequence (RS) over the past 10 years. In our institutional review, patients were excluded if they had a G-tube already placed at the time of surgery...
May 7, 2024: Annals of Otology, Rhinology, and Laryngology
#5
JOURNAL ARTICLE
Yi Lv, Qian Wang, Chensheng Lin, Xi Zheng, Yanding Zhang, Xuefeng Hu
The pivotal role of FGF18 in the regulation of craniofacial and skeletal development has been well established. Previous studies have demonstrated that mice with deficiency in Fgf18 exhibit severe craniofacial dysplasia. Recent clinical reports have revealed that the duplication of chromosome 5q32-35.3, which encompasses the Fgf18 gene, can lead to cranial bone dysplasia and congenital craniosynostosis, implicating the consequence of possible overdosed FGF18 signaling. This study aimed to test the effects of augmented FGF18 signaling by specifically overexpressing the Fgf18 gene in cranial neural crest cells using the Wnt1-Cre;pMes-Fgf18 mouse model...
2024: Frontiers in Cell and Developmental Biology
#6
Logan Foster, Declan Foster, Harsh Nathani, William Krogman
No abstract text is available yet for this article.
2024: Kansas Journal of Medicine
#7
Vishal Kulkarni, Kumar C Senthil, Mukti K Rath, Madhu Singh
Pierre Robin sequence poses a great challenge for anesthesiologists during laryngoscopy and intubation, making oxygenation and ventilation difficult. The role of early surgical intervention is recommended for the improvement of the airway and overall survival of the neonate. The situation becomes even more challenging, when the neonate may not be fit for such surgical interventions. The present case posed such a challenge to the team. To the authors' knowledge, the decision to use a face mask as an interim life-saving measure was considered for the first time...
2024: National Journal of Maxillofacial Surgery
#8
JOURNAL ARTICLE
Robin Khatri, Pierre Machart, Stefan Bonn
Cell deconvolution is the estimation of cell type fractions and cell type-specific gene expression from mixed data. An unmet challenge in cell deconvolution is the scarcity of realistic training data and the domain shift often observed in synthetic training data. Here, we show that two novel deep neural networks with simultaneous consistency regularization of the target and training domains significantly improve deconvolution performance. Our algorithm, DISSECT, outperforms competing algorithms in cell fraction and gene expression estimation by up to 14 percentage points...
April 30, 2024: Genome Biology
#9
JOURNAL ARTICLE
Robin Schaffar, Simone Benhamou, Pierre O Chappuis, Elisabetta Rapiti
PURPOSE: Breast cancer (BC) in women under 45 is rare yet often aggressive. We aim to analyze loco-regional recurrences (LR), distant recurrences (DR), second breast cancers, and mortality in young BC patients. METHODS: We enrolled 776 women with non-metastatic BC ≤45 years diagnosed from 1970 to 2012. Variables included age, family history, tumor stage/grade, and treatment. We used multivariate Cox regression and competing risk models. RESULTS: Among the participants, 37...
April 30, 2024: Breast Cancer Research and Treatment
#10
JOURNAL ARTICLE
Audrey Mohr, Maria Eugenia Marques Da Costa, Olivia Fromigue, Baptiste Audinot, Thierno Balde, Robin Droit, Samuel Abbou, Pierre Khneisser, Pablo Berlanga, Esperanza Perez, Antonin Marchais, Nathalie Gaspar
High-grade osteosarcoma is the most common paediatric bone cancer. More than one third of patients relapse and die of osteosarcoma using current chemotherapeutic and surgical strategies. To improve outcomes in osteosarcoma, two crucial challenges need to be tackled: 1-the identification of hard-to-treat disease, ideally from diagnosis; 2- choosing the best combined or novel therapies to eradicate tumor cells which are resistant to current therapies leading to disease dissemination and metastasize as well as their favorable microenvironment...
April 25, 2024: European Journal of Medical Genetics
#11
JOURNAL ARTICLE
Ange Lorenzi, Fabrice Legeai, Véronique Jouan, Pierre-Alain Girard, Michael R Strand, Marc Ravallec, Magali Eychenne, Anthony Bretaudeau, Stéphanie Robin, Jeanne Rochefort, Mathilde Villegas, Gaelen R Burke, Rita Rebollo, Nicolas Nègre, Anne-Nathalie Volkoff
Thousands of endoparasitoid wasp species in the families Braconidae and Ichneumonidae harbor "domesticated endogenous viruses" (DEVs) in their genomes. This study focuses on ichneumonid DEVs, named ichnoviruses (IVs). Large quantities of DNA-containing IV virions are produced in ovary calyx cells during the pupal and adult stages of female wasps. Females parasitize host insects by injecting eggs and virions into the body cavity. After injection, virions rapidly infect host cells which is followed by expression of IV genes that promote the successful development of wasp offspring...
April 25, 2024: PLoS Pathogens
#12
JOURNAL ARTICLE
Mathieu Pioche, João A Cunha Neves, Heiko Pohl, Minh Quyen, Raphaelle Grau, Xavier Dray, Clara Yzet, Mikael Mochet, Jeremie Jacques, Timothee Wallenhorst, Jérôme Rivory, Nadege Siret, Anne-Laure Peillet, Jean-Baptiste Chevaux, Francois Mion, Ulriikka Chaput, Philippe Jacob, Daniel Grinberg, Jean-Christophe Saurin, Robin Baddeley, Enrique Rodriguez de Santiago, Pierre-Jean Cottinet
INTRODUCTION: The environmental impact of endoscopy, including small-bowel capsule endoscopy (SBCE), has gained attention due to its contribution to the global carbon footprint. This study aimed to evaluate the greenhouse gas (GHG) emissions (kgCO2e) of SBCE, including devices life cycle and capsule journey. METHODS: SBCE devices (3 brands) were evaluated using life cycle assessment methodology (ISO 14040), including patient travelling, bowel preparation, capsule examination and video recording...
April 24, 2024: Endoscopy
#13
JOURNAL ARTICLE
Long-term mandibular growth in patients with airway obstruction treated with mandibular distraction.
Maria Costanza Meazzini, Alejandro Piza, Novelli Giorgio, Davide Sozzi, Elena de Ponti, Fabio Mazzoleni
Congenital craniofacial malformations play an important role in upper airway obstruction. One of the main causes is mandibular hypoplasia which is present in the pierre robin sequence. Mandibular distraction osteogenesis (MDO) is one of the most commonly used treatments for the resolution of upper airway obstruction in patients that do not respond to a conservative treatment. We performed a long term follow up of syndromic and non-syndromic patients with pierre robin sequence where the lateral xrays were studied before surgery (T1), after MDO (T2) and long-term follow-up (T3, at least 5 years)...
March 31, 2024: Journal of Cranio-maxillo-facial Surgery
#14
REVIEW
Pierre Scheffler, Christian Fung, Shahan Momjian, Dominik Koessinger, Levin Häni, Nicolas Neidert, Jakob Straehle, Florian Volz, Oliver Schnell, Jürgen Beck, Amir El Rahal
OBJECTIVE: Glioblastomas are the most common primary central nervous system (CNS) tumors. Although modern management strategies have modestly improved overall survival, the prognosis remains dismal, with treatment side effects often impinging on the clinical course. Glioblastomas cause neurological dysfunction by infiltrating CNS tissue and via perifocal oedema formation. The administration of steroids such as dexamethasone is thought to alleviate symptoms by reducing oedema. However, despite its widespread use, the evidence for the administration of dexamethasone is limited and conflicting...
April 1, 2024: Cancers
#15
JOURNAL ARTICLE
Agnès Lewden, Chelsea Ward, Aude Noiret, Sandra Avril, Lucie Abolivier, Caroline Gérard, Tracey L Hammer, Émilie Raymond, Jean-Patrice Robin, Vincent A Viblanc, Pierre Bize, Antoine Stier
Assessing the physiological stress responses of wild animals opens a window for understanding how organisms cope with environmental challenges. Since stress response is associated with changes in body temperature, the use of body surface temperature through thermal imaging could help to measure acute and chronic stress responses non-invasively. We used thermal imaging, acute handling-stress protocol and an experimental manipulation of corticosterone (the main glucocorticoid hormone in birds) levels in breeding king penguins (Aptenodytes patagonicus), to assess: 1...
April 10, 2024: Journal of Thermal Biology
#16
JOURNAL ARTICLE
Frederick S Vom Saal, Michael Antoniou, Scott M Belcher, Ake Bergman, Ramji K Bhandari, Linda S Birnbaum, Aly Cohen, Terrence J Collins, Barbara Demeneix, Anne Marie Fine, Jodi A Flaws, Veronique Gayrard, William H Goodson, Andrea C Gore, Jerrold J Heindel, Patricia A Hunt, Taisen Iguchi, Christopher D Kassotis, Andreas Kortenkamp, Robin Mesnage, Jane Muncke, John Peterson Myers, Angel Nadal, Retha R Newbold, Vasantha Padmanabhan, Paola Palanza, Zandra Palma, Stefano Parmigiani, Lyn Patrick, Gail S Prins, Cheryl S Rosenfeld, Niels E Skakkebaek, Carlos Sonnenschein, Ana M Soto, Shanna H Swan, Julia A Taylor, Pierre-Louis Toutain, Frank A von Hippel, Wade V Welshons, Daniel Zalko, R Thomas Zoeller
BACKGROUND: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>0.2</mml:mn><mml:mtext> ng</mml:mtext><mml:mo>/</mml:mo><mml:mi>kg</mml:mi><mml:mtext> body weight </mml:mtext><mml:mo>(</mml:mo><mml:mtext>BW</mml:mtext><mml:mo>)</mml:mo><mml:mo>/</mml:mo><mml:mtext>day</mml:mtext></mml:mrow></mml:math>...
April 2024: Environmental Health Perspectives
#17
JOURNAL ARTICLE
Tarek Sharshar, Lamiae Grimaldi-Bensouda, Shidasp Siami, Alain Cariou, Abdel Ben Salah, Pierre Kalfon, Romain Sonneville, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Bruno Megarbane, Stephane Gaudry, Haikel Oueslati, Segolene Robin-Lagandre, Carole Schwebel, Aurelien Mazeraud, Djillali Annane, Lionelle Nkam, Diane Friedman
PURPOSE: Critical illness is associated with long-term increased mortality and impaired quality of life (QoL). We assessed whether multidisciplinary consultations would improve outcome at 12 months (M12) after intensive care unit (ICU) discharge. METHODS: We performed an open, multicenter, parallel-group, randomized clinical trial. Eligible are patients discharged alive from ICU in 11 French hospitals between 2012 and 2018. The intervention group had a multidisciplinary face-to-face consultation involving an intensivist, a psychologist, and a social worker at ICU discharge and then at M3 and M6 (optional)...
April 8, 2024: Intensive Care Medicine
#18
JOURNAL ARTICLE
Ariane Bollack, Lyduine E Collij, David Vállez García, Mahnaz Shekari, Daniele Altomare, Pierre Payoux, Bruno Dubois, Oriol Grau-Rivera, Mercè Boada, Marta Marquié, Agneta Nordberg, Zuzana Walker, Philip Scheltens, Michael Schöll, Robin Wolz, Jonathan M Schott, Rossella Gismondi, Andrew Stephens, Christopher Buckley, Giovanni B Frisoni, Bernard Hanseeuw, Pieter Jelle Visser, Rik Vandenberghe, Alexander Drzezga, Maqsood Yaqub, Ronald Boellaard, Juan Domingo Gispert, Pawel Markiewicz, David M Cash, Gill Farrar, Frederik Barkhof
INTRODUCTION: To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations. METHODS: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18 F]flutemetamol, [18 F]florbetaben or [18 F]florbetapir amyloid-PET were included...
April 4, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#19
JOURNAL ARTICLE
Pierre-André Jarrot, Adrien Mirouse, Sébastien Ottaviani, Simon Cadiou, Jean-Hugues Salmon, Eric Liozon, Simon Parreau, Martin Michaud, Benjamin Terrier, Pierre-Edouard Gavand, Ludovic Trefond, Virginie Lavoiepierre, Jeremy Keraen, Daniel Rekassa, Bastien Bouldoires, Thierry Weitten, Damien Roche, Antoine Poulet, Caroline Charpin, Vincent Grobost, Marion Hermet, Magali Pallure, Chloe Wackenheim, Ludovic Karkowski, Pierre Grumet, Thomas Rogier, Nabil Belkefi, Vincent Pestre, Emilie Broquet, Amélie Leurs, Sophie Gautier, Valérie Gras, Pierre Gilet, Jan Holubar, Nadia Sivova, Nicolas Schleinitz, Jean-Marc Durand, Brice Castel, Alexandre Petrier, Robin Arcani, Baptiste Gramont, Philippe Guilpain, Hubert Lepidi, Pierre-Jean Weiller, Joelle Micallef, David Saadoun, Gilles Kaplanski
We conducted a national in-depth analysis including pharmacovigilance reports and clinical study to assess the reporting rate (RR) and to determine the clinical profile of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) in COVID-19-vaccinated individuals. First, based on the French pharmacovigilance database, we estimated the RR of PMR and GCA cases in individuals aged over 50 who developed their initial symptoms within one month of receiving the BNT162b2 mRNA, mRNA-1273, ChAdOx1 nCoV-19, and Ad26...
December 31, 2024: Human Vaccines & Immunotherapeutics
#20
JOURNAL ARTICLE
James Butterfield, Megan Pencek, Keith Sweitzer, Eileen Marrinan, Heidi Connolly, Sara Neimanis, Clinton Morrison
BACKGROUND: Pharyngeal flap (PF) surgery is effective at improving velopharyngeal sufficiency, but historical literature shows a concerning prevalence rate of obstructive sleep apnea (OSA), reported as high as 20%. Our institution has developed a protocol to minimize risk of postoperative obstructive complications and increase safety of PF surgery. We hypothesize that (1) preoperative staged removal of significant adenotonsillar tissue along with (2) multiview videofluoroscopy to guide patient-specific surgical approach via appropriately sized PFs can result in excellent speech outcomes while limiting occurrence of OSA...
April 1, 2024: Annals of Plastic Surgery
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
