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https://www.readbyqxmd.com/read/28227557/sudden-changes-in-walking-surface-compliance-evoke-contralateral-emg-in-a-hemiparetic-walker-a-case-study-of-inter-leg-coordination-after-neurological-injury
#1
Jeffrey Skidmore, Panagiotis Artemiadis, Jeffrey Skidmore, Panagiotis Artemiadis, Jeffrey Skidmore, Panagiotis Artemiadis
Gait impairment due to neurological disorders is a significant problem around the world. Despite the growing interest in using robotic devices for gait rehabilitation, their widespread use remains limited as there is no clear evidence that robot-assisted gait therapy is superior to traditional treadmill-based therapy. This work is a case study that focuses on investigating the existence of mechanisms of inter-leg coordination after neurological injury, and based on that, proposing novel methods for gait rehabilitation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227186/aart-bc-a-sensor-system-for-monitoring-assistive-technology-use-beyond-the-clinic
#2
Christopher J James, James D Amor, Catherine Holloway, Tsu-Jui Cheng, Laurence Kenney, Christopher J James, James D Amor, Catherine Holloway, Tsu-Jui Cheng, Laurence Kenney, Tsu-Jui Cheng, Laurence Kenney, Christopher J James, Catherine Holloway, James D Amor
A wide range of assistive and rehabilitative technologies (ART) are available to assist with mobility and upper limb function. However, anecdotal evidence suggests many of the devices prescribed, or purchased, are either poorly used, or rejected entirely. This situation is costly, both for the healthcare provider and the user, and may be leading to secondary consequences, such as falls and/or social isolation. This paper reports on the development and initial feasibility testing of a system for monitoring when and how assistive devices are used outside of the clinic setting, and feeding this information to the device user themselves and/or prescribing clinician (where appropriate)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227007/identification-of-blood-biomarkers-for-use-in-point-of-care-diagnosis-tool-for-alzheimer-s-disease
#3
E Jammeh, P Zhao, C Carroll, S Pearson, E Ifeachor, E Jammeh, P Zhao, C Carroll, S Pearson, E Ifeachor, C Carroll, E Jammeh, E Ifeachor, S Pearson, P Zhao
Early diagnosis of Alzheimer's Disease (AD) is widely regarded as necessary to allow treatment to be started before irreversible damage to the brain occur and for patients to benefit from new therapies as they become available. Low-cost point-of-care (PoC) diagnostic tools that can be used to routinely diagnose AD in its early stage would facilitate this, but such tools require reliable and accurate biomarkers. However, traditional biomarkers for AD use invasive cerebrospinal fluid (CSF) analysis and/or expensive neuroimaging techniques together with neuropsychological assessments...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226405/comparative-effectiveness-of-long-acting-beta2-agonist-combined-with-a-long-acting-muscarinic-antagonist-or-inhaled-corticosteroid-in-chronic-obstructive-pulmonary-disease
#4
Jennifer C Samp, Min J Joo, Glen T Schumock, Gregory S Calip, A Simon Pickard, Todd A Lee
INTRODUCTION: Several dual bronchodilator fixed dose inhaler medications were recently approved for the treatment of chronic obstructive pulmonary disease (COPD). These products combine a long-acting beta2 -agonist (LABA) and long-acting muscarinic antagonist (LAMA). In clinical trials, the separate mechanisms of the bronchodilators resulted in improved lung function. COPD treatment guidelines currently recommend combination LABA/LAMA as alternative therapy to combination LABA/ inhaled corticosteroid (ICS)...
February 22, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28226264/leukocyte-telomere-length-in-hispanic-schizophrenia-patients-under-treatment-with-olanzapine
#5
Nancy Monroy-Jaramillo, Yaneth Rodríguez-Agudelo, Luis Carlos Aviña-Cervantes, David L Roberts, Dawn I Velligan, Consuelo Walss-Bass
Different lines of evidence indicate that patients with schizophrenia (SZ) exhibit accelerated aging. Leukocyte telomere length (TL), an aging marker, is associated with age-related and chronic pathologies, including schizophrenia. We analyzed leukocyte TL in 170 SZ patients of Hispanic ancestry grouped based on antipsychotic treatment, compared to 126 matched controls. The group under treatment with atypical antipsychotics was further subdivided according to the risk of medication to cause metabolic syndrome (MetS)...
February 10, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28226261/effectiveness-of-public-health-messaging-and-communication-channels-during-smoke-events-a-rapid-systematic-review
#6
REVIEW
Jennifer A Fish, Micah D J Peters, Imogen Ramsey, Greg Sharplin, Nadia Corsini, Marion Eckert
Exposure to smoke emitted from wildfire and planned burns (i.e., smoke events) has been associated with numerous negative health outcomes, including respiratory symptoms and conditions. This rapid review investigates recent evidence (post-2009) regarding the effectiveness of public health messaging during smoke events. The objectives were to determine the effectiveness of various communication channels used and public health messages disseminated during smoke events, for general and at-risk populations. A search of 12 databases and grey literature yielded 1775 unique articles, of which 10 were included in this review...
February 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28225876/anticoagulation-in-acute-ischemic-stroke-a-systematic-search
#7
Nayara L Froio, Richard Murdoch Montgomery, Elias David-Neto, Ivan Aprahamian
INTRODUCTION: Stroke is one of the most important diseases worldwide. Several clinical scenarios demand full dose of anticoagulants primary to stroke etiology or to the treatment of comorbidity. However, controversy exists over many issues regarding anticoagulation treatment in stroke such as time for initiation, efficacy according to stroke etiology, the ideal dose of anticoagulants, and whether novel anticoagulants should be used. METHOD: Computerized search for clinical trials and randomized controlled clinical trials was done to the present date at Medline, Scielo, Embase, PsychInfo, and Cochrane Library using MeSH terms and the keywords stroke, ischemic stroke, anticoagulation, anticoagulants, heparin, low-molecular-weight heparin, warfarin, dabigatran, rivaroxaban, apixaban...
January 1, 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28225817/binational-climate-change-vulnerability-assessment-of-migratory-birds-in-the-great-lakes-basins-tools-and-impediments
#8
Robert S Rempel, Megan L Hornseth
Climate change is a global concern, requiring international strategies to reduce emissions, however, climate change vulnerability assessments are often local in scope with assessment areas restricted to jurisdictional boundaries. In our study we explored tools and impediments to understanding and responding to the effects of climate change on vulnerability of migratory birds from a binational perspective. We apply and assess the utility of a Climate Change Vulnerability Index on 3 focal species using distribution or niche modeling frameworks...
2017: PloS One
https://www.readbyqxmd.com/read/28225769/management-of-vesicovaginal-fistulas-vvfs-in-women-following-benign-gynaecologic-surgery-a-systematic-review-and-meta-analysis
#9
Barbara Bodner-Adler, Engelbert Hanzal, Eleonore Pablik, Heinz Koelbl, Klaus Bodner
BACKGROUND: Vesicovaginal fistulas (VVF) are the most commonly acquired fistulas of the urinary tract, but we lack a standardized algorithm for their management. Surgery is the most commonly preferred approach to treat women with primary VVF following benign gynaecologic surgery. OBJECTIVE: To carry out a systematic review and meta-analysis on the effectiveness of operative techniques or conservative treatment for patients with postsurgical VVF. Our secondary objective was to define the surgical time and determine the types of study designs...
2017: PloS One
https://www.readbyqxmd.com/read/28225740/early-pancreatic-dysfunction-after-resection-in-trauma-an-18-year-report-from-a-level-i-trauma-center
#10
Nicole Mansfield, Kenji Inaba, Regan Berg, Elizabeth Beale, Elizabeth Benjamin, Lydia Lam, Kazuhide Matsushima, Demetrios Demetriades
BACKGROUND: Early pancreatic dysfunction after resection in trauma has not been well characterized. The objective of this study was to examine the incidence and clinical impact of new-onset endocrine and exocrine dysfunction after pancreatic resection for trauma. METHODS: All patients sustaining a pancreatic injury from 1996 to 2013 were identified. Patients with preinjury diabetes were excluded. Survivors were divided into three groups according to the extent of anatomic resection-distal, proximal, or total pancreatectomy...
March 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28225644/a-narrative-synthesis-of-nintendo-wii-fit-gaming-protocol-in-addressing-balance-among-healthy-older-adults-what-system-works
#11
Donald G Manlapaz, Gisela Sole, Prasath Jayakaran, Cathy M Chapple
BACKGROUND: Balance is crucial in performing functional tasks particularly among older adults. Exergaming is gaining attention as a novel approach to enhance balance in a number of clinical populations. OBJECTIVES: The aim of this review was to synthesize and present published evidence for Nintendo Wii Fit™ gaming system protocols. These include game preference, intervention setting, and exercise dosage for improving balance in healthy older adults. Commonly used outcome measures were also identified...
February 22, 2017: Games for Health
https://www.readbyqxmd.com/read/28225561/flotillins-control-zebrafish-epiboly-through-their-role-in-cadherin-mediated-cell-cell-adhesion
#12
Eduardo A Rios Morris, Stéphane Bodin, Bénédicte Delaval, Franck Comunale, Virginie Georget, Manoel L Costa, Georges Lutfalla, Cécile Gauthier-Rouvière
Zebrafish gastrulation and particularly epiboly that involves coordinated movements of several cell layers is a dynamic process for which regulators remain to be identified. We show here that Flotillin 1 and 2, ubiquitous and highly conserved proteins, are required for epiboly. Flotillins knockdown compromised embryo survival, strongly delayed epiboly and impaired deep cell radial intercalation and directed collective migration without affecting enveloping layer cell movement. At the molecular level, we identified that Flotillins are required for the formation of E-cadherin-mediated cell-cell junctions...
February 22, 2017: Biology of the Cell
https://www.readbyqxmd.com/read/28225312/perspectives-on-learning-and-clinical-practice-improvement-for-diabetes-in-the-hospital-a-review-of-educational-interventions-for-providers
#13
Ariana Pichardo-Lowden, Paul Haidet, Guillermo E Umpierrez
BACKGROUND: The management inpatient hyperglycemia and diabetes requires expertise among many healthcare providers. There is limited evidence about how education for healthcare providers can result in optimization of clinical outcomes. The purpose of this critical review of the literature is to examine methods and outcomes related to educational interventions regarding the management of diabetes and dysglycemia in the hospital setting. This report provides recommendations to advance learning, curricular planning and clinical practice...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225303/initial-diagnostic-workup-of-acute-leukemia-guideline-from-the-college-of-american-pathologists-and-the-american-society-of-hematology
#14
Daniel A Arber, Michael J Borowitz, Melissa Cessna, Joan Etzell, Kathryn Foucar, Robert P Hasserjian, J Douglas Rizzo, Karl Theil, Sa A Wang, Anthony T Smith, R Bryan Rumble, Nicole E Thomas, James W Vardiman
CONTEXT: -A complete diagnosis of acute leukemia requires knowledge of clinical information combined with morphologic evaluation, immunophenotyping and karyotype analysis, and often, molecular genetic testing. Although many aspects of the workup for acute leukemia are well accepted, few guidelines have addressed the different aspects of the diagnostic evaluation of samples from patients suspected to have acute leukemia. OBJECTIVE: -To develop a guideline for treating physicians and pathologists involved in the diagnostic and prognostic evaluation of new acute leukemia samples, including acute lymphoblastic leukemia, acute myeloid leukemia, and acute leukemias of ambiguous lineage...
February 22, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28224897/cellulose-pectin-composite-hydrogels-intermolecular-interactions-and-material-properties-depend-on-order-of-assembly
#15
Patricia Lopez-Sanchez, Marta Martinez-Sanz, Mauricio R Bonilla, Dongjie Wang, Elliot P Gilbert, Jason R Stokes, Michael J Gidley
Plant cell walls have a unique combination of strength and flexibility however, further investigations are required to understand how those properties arise from the assembly of the relevant biopolymers. Recent studies indicate that Ca(2+)-pectates can act as load-bearing components in cell walls. To investigate this proposed role of pectins, bioinspired wall models were synthesised based on bacterial cellulose containing pectin-calcium gels by varying the order of assembly of cellulose/pectin networks, pectin degree of methylesterification and calcium concentration...
April 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28224502/pyoderma-gangrenosum-an-update-on-pathophysiology-diagnosis-and-treatment
#16
REVIEW
Afsaneh Alavi, Lars E French, Mark D Davis, Alain Brassard, Robert S Kirsner
Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic disorder with prototypical clinical presentations. Its pathophysiology is complex and not fully explained. Recent information regarding the genetic basis of PG and the role of auto-inflammation provides a better understanding of the disease and new therapeutic targets. PG equally affects patients of both sexes and of any age. Uncontrolled cutaneous neutrophilic inflammation is the cornerstone in a genetically predisposed individual. Multimodality management is often required to reduce inflammation, optimize wound healing, and treat underlying disease...
February 21, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28224351/subcirrhotic-liver-stiffness-by-fibroscan-correlates-with-lower-risk-of-hepatocellular-carcinoma-in-patients-with-hbv-related-cirrhosis
#17
Mi Young Jeon, Hye Won Lee, Seung Up Kim, Ja Yoon Heo, Sojung Han, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han
BACKGROUND AND AIMS: The risk of developing hepatocellular carcinoma (HCC) varies, even in the context of cirrhosis. We investigated the relationship between liver stiffness (LS) in subcirrhotic range, assessed via transient elastography (TE), and risk of HCC development in patients with chronic hepatitis B (CHB)-related cirrhosis. METHODS: Data on 540 patients presenting with clinically evident CHB-related cirrhosis between April 2006 and December 2014 were reviewed retrospectively...
February 21, 2017: Hepatology International
https://www.readbyqxmd.com/read/28224348/a-need-to-reconsider-guidelines-on-management-of-primary-spontaneous-pneumothorax
#18
Jiyoon Yoon, Parthipan Sivakumar, Kevin O'Kane, Liju Ahmed
BACKGROUND: The key guidelines in the management of primary spontaneous pneumothorax (PSP) include the 2010 British Thoracic Society (BTS) Pleural Disease guideline and 2001 American College of Chest Physicians (ACCP) Consensus Statement. Current recommendations are dependent on radiographic measures which differ between these two guidelines. The aim of this study is to compare size classification of PSP cases, according to BTS and ACCP guidelines, and to evaluate guideline compliance...
December 2017: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28224314/creating-semantics-in-tool-use
#19
Arnaud Badets, Thomas Michelet, Aymar de Rugy, François Osiurak
This article presents the first evidence for a functional link between tool use and the processing of abstract symbols like Arabic numbers. Participants were required to perform a tool-use task after the processing of an Arabic number. These numbers represented either a small (2 or 3) or a large magnitude (8 or 9). The tool-use task consisted in using inverse pliers for gripping either a small or a large object. The inverse pliers enable to dissociate the hand action from the tool action in relation to the object (i...
February 21, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28224275/the-english-national-screening-programme-for-diabetic-retinopathy-2003-2016
#20
Peter H Scanlon
The aim of the English NHS Diabetic Eye Screening Programme is to reduce the risk of sight loss amongst people with diabetes by the prompt identification and effective treatment if necessary of sight-threatening diabetic retinopathy, at the appropriate stage during the disease process. In order to achieve the delivery of evidence-based, population-based screening programmes, it was recognised that certain key components were required. It is necessary to identify the eligible population in order to deliver the programme to the maximum number of people with diabetes...
February 22, 2017: Acta Diabetologica
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