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https://www.readbyqxmd.com/read/28527040/fundamental-principles-of-an-anti-vegf-treatment-regimen-optimal-application-of-intravitreal-anti-vascular-endothelial-growth-factor-therapy-of-macular-diseases
#1
REVIEW
Paolo Lanzetta, Anat Loewenstein
BACKGROUND: Intravitreal anti-vascular endothelial growth factor (VEGF) therapy is now considered the gold standard for the treatment of various retinal disorders. As therapy has evolved, so too have the treatment regimens employed by physicians in clinical practice; however, visual outcomes observed in the real world have typically not reflected those reported in clinical trials. Possible reasons for this include a lack of consensus on treatment regimens and a lack of clarity about what the aims of treatment should be...
May 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28524743/nanoparticle-exposures-from-nano-enabled-toner-based-printing-equipment-and-human-health-state-of-science-and-future-research-needs
#2
Sandra Vanessa Pirela, John Martin, Dhimiter Bello, Philip Demokritou
Toner formulations used by laser printers (LP) and photocopiers (PC), collectively called "toner-based printing equipment" (TPE), are nano-enabled products (NEP) because they contain several engineered nanomaterials (ENM) that improve toner performance. It has been shown that during consumer use (printing), these ENM are released in the air, together with other semi-volatile organic nanoparticles, and newly formed gaseous co-pollutants such as volatile organic compounds (VOC). The aim of this review is to detail and analyze physico-chemical and morphological (PCM), as well as the toxicological properties of particulate matter (PM) emissions from TPE...
May 19, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28523466/recognition-induced-forgetting-does-not-occur-for-temporally-grouped-objects-unless-they-are-semantically-related
#3
Ashleigh M Maxcey, Hannah Glenn, Elisabeth Stansberry
Recent evidence has shown that practice recognizing certain objects hurts memories of objects from the same category, a phenomenon called recognition-induced forgetting. In all previous studies of this effect, the objects have been related by semantic category (e.g., instances of vases). However, the relationship between objects in many real-world visual situations stresses temporal grouping rather than semantic relations (e.g., a weapon and getaway car at a crime scene), and temporal grouping is thought to cluster items in models of long-term memory...
May 18, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28514322/relationship-between-a-sepsis-intervention-bundle-and-in-hospital-mortality-among-hospitalized-patients-a-retrospective-analysis-of-real-world-data
#4
Priya A Prasad, Erica R Shea, Stephen Shiboski, Mary C Sullivan, Ralph Gonzales, David Shimabukuro
BACKGROUND: Sepsis is a systemic response to infection that can lead to tissue damage, organ failure, and death. Efforts have been made to develop evidence-based intervention bundles to identify and manage sepsis early in the course of the disease to decrease sepsis-related morbidity and mortality. We evaluated the relationship between a minimally invasive sepsis intervention bundle and in-hospital mortality using robust methods for observational data. METHODS: We performed a retrospective cohort study at the University of California, San Francisco, Medical Center among adult patients discharged between January 1, 2012, and December 31, 2014, and who received a diagnosis of severe sepsis/septic shock (SS/SS)...
May 12, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28510210/brain-connectivity-during-encoding-and-retrieval-of-spatial-information-individual-differences-in-navigation-skills
#5
Greeshma Sharma, Klaus Gramann, Sushil Chandra, Vijander Singh, Alok Prakash Mittal
Emerging evidence suggests that the variations in the ability to navigate through any real or virtual environment are accompanied by distinct underlying cortical activations in multiple regions of the brain. These activations may appear due to the use of different frame of reference (FOR) for representing an environment. The present study investigated the brain dynamics in the good and bad navigators using Graph Theoretical analysis applied to low-density electroencephalography (EEG) data. Individual navigation skills were rated according to the performance in a virtual reality (VR)-based navigation task and the effect of navigator's proclivity towards a particular FOR on the navigation performance was explored...
May 16, 2017: Brain Informatics
https://www.readbyqxmd.com/read/28508322/use-patterns-of-first-line-inhibitors-of-tyrosine-kinase-and-time-to-change-to-second-line-therapy-in-chronic-myeloid-leukemia
#6
Jorge Enrique Machado-Alba, Manuel Enrique Machado-Duque
Background Chronic myeloid leukemia (CML) has a low incidence but a high burden of disease, and is treated with high-cost tyrosine kinase inhibitors (TKI). Objective To determine the time from the start of a first-line TKI until it passes to second-line, and to establish the reasons for the change of therapy time. Setting Patients with Philadelphia-positive CML treated with some TKI. Methods Retrospective cohort study, between January 1 2007 and July 31 2015, with information obtained from medical records, the time to change initial drugs to secondline therapy, and the reasons for change, were identified...
May 15, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28502809/challenges-of-informed-consent-for-pragmatic-trials
#7
Shona Kalkman, Ghislaine Jmw van Thiel, Mira Gp Zuidgeest, Iris Goetz, Boris M Pfeiffer, Diederick E Grobbee, Johannes Jm van Delden
The Innovative Medicines Initiative's (IMI) GetReal consortium aims to develop strategies to incorporate real world evidence earlier into the drug life cycle to better inform health care decision-makers on the comparative risks and benefits of new drugs. Pragmatic trials are currently explored as a means to generate such evidence in routine care settings. The traditional informed consent model for randomized clinical trials has been argued to pose substantial hurdles to the practicability of pragmatic trials: it would lead to recruitment difficulties, reduced generalizability of the results and selection bias...
May 11, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28502244/evaluating-the-implementation-of-integrated-mental-health-care-a-systematic-review-to-guide-the-development-of-quality-measures
#8
Nadiya Sunderji, Allyson Ion, Abbas Ghavam-Rassoul, Amanda Abate
OBJECTIVE: Although the effectiveness of integrated mental health care has been demonstrated, its implementation in real-world settings is highly variable, may not conform to evidence-based practice, and has rarely been evaluated. Quality indicators can guide improvements in integrated care implementation. However, the literature on indicators for this purpose is limited. This article reports findings from a systematic review of existing measures by which to evaluate integrated care models in primary care settings...
May 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28498234/long-term-outcomes-of-carotid-endarterectomy-versus-stenting-in-a-multicenter-population-based-canadian-study
#9
Mohamad A Hussain, Muhammad Mamdani, Jack V Tu, Gustavo Saposnik, Badr Aljabri, Deepak L Bhatt, Subodh Verma, Mohammed Al-Omran
OBJECTIVE: To compare the long-term outcomes of patients treated with carotid endarterectomy and carotid-artery stenting. BACKGROUND: Evidence for the long-term safety and efficacy of carotid-artery stenting compared with endarterectomy is accumulating from randomized trials. However, comparative data on the long-term outcomes of carotid revascularization strategies in real world practice are lacking. METHODS: We conducted a population-based, multicenter, observational cohort study using validated linked databases from Ontario, Canada...
May 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28498179/improving-retention-in-care-among-pregnant-women-and-mothers-living-with-hiv-lessons-from-inspire-and-implications-for-future-who-guidance-and-monitoring
#10
Nigel C Rollins, Shaffiq M Essajee, Nita Bellare, Meg Doherty, Gottfried O Hirnschall
Identifying women living with HIV, initiating them on lifelong antiretroviral treatment (ART), and retaining them in care are among the important challenges facing this generation of health care managers and public health researchers. Implementation research attempts to solve a wide range of implementation problems by trying to understand and work within real-world conditions to find solutions that have a measureable impact on the outcomes of interest. Implementation research is distinct from clinical research in many ways yet demands similar standards of conceptual thinking and discipline to generate robust evidence that can be, to some extent, generalized to inform policy and service delivery...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28497928/effects-of-dual-and-complex-task-on-walking-ability-of-ambulatory-individuals-with-spinal-cord-injury
#11
Kitiyawadee Srisim, Thiwabhorn Thaweewannakij, Preeda Arrayawichanon, Pipatana Amatachaya, Lugkana Mato, Sugalya Amatachaya
BACKGROUND: Attempting to perform dual- and complex-tasks obviously reduces the walking ability of individuals with impaired cognitive functions. However, there is no clear evidence describing the effects of dual- and complex-tasks on the walking ability of ambulatory individuals with a spinal cord injury (SCI) who have intact cognitive functions, but suffer from various degrees of sensorimotor deterioration. AIM: To primarily investigate the effects of dual- and complex-task on the walking ability of ambulatory subjects with SCI as compared to healthy individuals...
May 12, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28494811/the-association-between-implementation-strategy-use-and-the-uptake-of-hepatitis-c-treatment-in-a-national-sample
#12
Shari S Rogal, Vera Yakovchenko, Thomas J Waltz, Byron J Powell, JoAnn E Kirchner, Enola K Proctor, Rachel Gonzalez, Angela Park, David Ross, Timothy R Morgan, Maggie Chartier, Matthew J Chinman
BACKGROUND: Hepatitis C virus (HCV) is a common and highly morbid illness. New medications that have much higher cure rates have become the new evidence-based practice in the field. Understanding the implementation of these new medications nationally provides an opportunity to advance the understanding of the role of implementation strategies in clinical outcomes on a large scale. The Expert Recommendations for Implementing Change (ERIC) study defined discrete implementation strategies and clustered these strategies into groups...
May 11, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28493741/how-actions-taken-or-not-under-alcohol-influence-inhibitory-control-and-perceived-impairment
#13
Cecile A Marczinski
Consumption of alcohol can lead to the impairment of the ability to suppress inappropriate responses. However, alcohol-induced disinhibition does not occur in all contexts in the real world. Therefore, the purpose of this study was to examine if actions taken (or not) under alcohol will impact observed inhibitory control and how behavioral control requirements under alcohol alter perceived levels of impairment. Participants (n = 40) of equal sex who were social drinkers participated in a 3 session laboratory study that involved the administration of placebo, 0...
June 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28493653/technology-assisted-parent-training-programs-for-children-and-adolescents-with-disruptive-behaviors-a-systematic-review
#14
Amit Baumel, Aditya Pawar, Nandita Mathur, John M Kane, Christoph U Correll
OBJECTIVE: To systematically review digitally assisted parent training programs (DPTs) targeting the treatment of children and adolescents with disruptive behaviors. DATA SOURCES: A search was conducted using PubMed, PsycINFO, and EMBASE databases for peer-reviewed studies published between January 1, 2000, and March 1, 2016. Reference lists of included and review articles were searched manually for additional references. STUDY SELECTION: Broad search terms in varying combinations for parent, training, technologies, and disruptive behavior problems were used...
May 9, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28492562/-from-clinical-trials-to-clinical-practice-how-real-world-evidence-integrates-the-safety-and-efficacy-profile-of-rivaroxaban
#15
Furio Colivicchi
Real-world data are becoming increasingly important in providing healthcare professionals and public health policy makers with additional information besides that obtained from randomized controlled trials, which is more representative of everyday clinical settings involving heterogeneous patient populations. Real-life data analyses are particularly useful for the evaluation of new treatment options, including non-vitamin K antagonist oral anticoagulants (NOACs), which were shown to be effective and safe in randomized controlled trials but need further confirmation in unselected patient populations over the long term...
February 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28490417/accelerating-digital-mental-health-research-from-early-design-and-creation-to-successful-implementation-and-sustainment
#16
David C Mohr, Aaron R Lyon, Emily G Lattie, Madhu Reddy, Stephen M Schueller
Mental health problems are common and pose a tremendous societal burden in terms of cost, morbidity, quality of life, and mortality. The great majority of people experience barriers that prevent access to treatment, aggravated by a lack of mental health specialists. Digital mental health is potentially useful in meeting the treatment needs of large numbers of people. A growing number of efficacy trials have shown strong outcomes for digital mental health treatments. Yet despite their positive findings, there are very few examples of successful implementations and many failures...
May 10, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28490342/rethinking-alcohol-interventions-in-health-care-a-thematic-meeting-of-the-international-network-on-brief-interventions-for-alcohol-other-drugs-inebria
#17
Joseph E Glass, Sven Andréasson, Katharine A Bradley, Sara Wallhed Finn, Emily C Williams, Ann-Sofie Bakshi, Antoni Gual, Nick Heather, Marcela Tiburcio Sainz, Vivek Benegal, Richard Saitz
In 2016, the International Network on Brief Interventions for Alcohol & Other Drugs convened a meeting titled "Rethinking alcohol interventions in health care". The aims of the meeting were to synthesize recent evidence about screening and brief intervention and to set directions for research, practice, and policy in light of this evidence. Screening and brief intervention is efficacious in reducing self-reported alcohol consumption for some with unhealthy alcohol use, but there are gaps in evidence for its effectiveness...
May 10, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28485692/cost-effectiveness-of-denosumab-versus-zoledronic-acid-for-preventing-skeletal-related-events-in-the-czech-republic
#18
Joaquim Cristino, Jíndřich Finek, Petra Jandova, Martin Kolek, Bálint Pásztor, Christina Giannopoulou, Yi Qian, Tomas Brezina, Mickael Lothgren
AIMS: This study assessed the cost-effectiveness of the subcutaneous RANKL inhibitor, denosumab, versus the intravenous bisphosphonate, zoledronic acid, for the prevention of skeletal-related events (SREs) in patients with prostate cancer, breast cancer, and other solid tumors (OST) in the Czech Republic. MATERIALS AND METHODS: A lifetime Markov model was developed to compare the effects of denosumab and zoledronic acid on costs (including drug costs and administration, patient management, SREs, and adverse events), quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios from a national payer perspective...
May 9, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28485680/is-the-calorie-concept-a-real-solution-to-the-obesity-epidemic
#19
Salvador Camacho, Andreas Ruppel
BACKGROUND: The obesity epidemic has been growing steadily across the whole world, and so far not a single country has been able to reverse it. The cause of obesity is stated by the World Health Organization as an energy imbalance between calories consumed and calories expended. However, growing evidence suggests that the calorie imbalance concept may not be sufficient to manage and reverse the obesity epidemic. OBJECTIVE: To discuss the use of the calorie imbalance concept and its elements as a tool for weight management as well as its possible negative consequences and implications for public health, with the aim to point toward the need of an updated concept for causes of obesity...
2017: Global Health Action
https://www.readbyqxmd.com/read/28485636/a-systematic-review-of-psychosocial-interventions-for-adult-refugees-and-asylum-seekers
#20
Rachel H Tribe, Kyra-Verena Sendt, Derek K Tracy
BACKGROUND: Europe is in the midst of the largest refugee migration since the Second World War; there is an urgent need to provide an updated systematic review of the current best evidence for managing mental distress in refugee populations. AIMS: The aim of this review is to provide an exhaustive summary of the current literature on psychosocial interventions, both trauma- and non-trauma-focused, for refugee populations experiencing post-traumatic stress disorder (PTSD), depressive or anxiety symptoms...
May 9, 2017: Journal of Mental Health
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