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https://www.readbyqxmd.com/read/28103865/can-healthcare-utilization-data-reliably-capture-cases-of-chronic-respiratory-diseases-a-cross-sectional-investigation-in-italy
#1
A Biffi, R Comoretto, A Arfè, L Scotti, L Merlino, A Vaghi, A Pesci, R de Marco, G Corrao
BACKGROUND: Healthcare utilization data are increasingly used for chronic disease surveillance. Nevertheless, no standard criteria for estimating prevalence of high-impact diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, are available. In this study an algorithm for recognizing COPD/asthma cases from HCU data is developed and implemented in the HCU databases of the Italian Lombardy Region (about 10 million residents). The impact of diagnostic misclassification for reliably estimating prevalence was also assessed...
January 19, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28103824/management-prognosis-and-predictors-of-unfavourable-outcomes-in-patients-newly-hospitalized-for-transient-ischemic-attack-a-real-world-investigation-from-italy
#2
Giovanni Corrao, Federico Rea, Luca Merlino, Paolo Mazzola, Federico Annoni, Giorgio Annoni
BACKGROUND: Understanding the gap between evidence-based recommendations and real-world management is important to inform priority setting and health service planning. METHODS: The 7,776 residents in the Italian Lombardy Region who were newly hospitalized for transient ischemic attack (TIA) during 2008-2009 entered into the cohort and were followed until 2012. Exposure to medical care including selected drugs, diagnostic procedures and laboratory tests was recorded...
January 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28103066/practice-based-evidence-in-community-guide-systematic-reviews
#3
Namita Vaidya, Anilkrishna B Thota, Krista K Proia, Sara Jamieson, Shawna L Mercer, Randy W Elder, Paula Yoon, Rachel Kaufmann, Stephanie Zaza
OBJECTIVES: To assess the relative contributions and quality of practice-based evidence (PBE) and research-based evidence (RBE) in The Guide to Community Preventive Services (The Community Guide). METHODS: We developed operational definitions for PBE and RBE in which the main distinguishing feature was whether allocation of participants to intervention and comparison conditions was under the control of researchers (RBE) or not (PBE). We conceptualized a continuum between RBE and PBE...
January 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28102714/validity-and-reliability-of-a-questionnaire-to-assess-social-skills-in-traumatic-brain-injury-a-preliminary-study
#4
Heather M Francis, Katherine Osborne-Crowley, Skye McDonald
OBJECTIVE: To describe the reliability and validity of a new measure, the Social Skills Questionnaire for Traumatic Brain Injury (SSQ-TBI). METHODS: Fifty-one adults with severe TBI completed the SSQ-TBI questionnaire. Scores were compared to informant- and self-report on questionnaires addressing frontal lobe mediated behaviour, as well as performance on an objective measure of social cognition and neuropsychological tasks, in order to provide evidence of concurrent, divergent and predictive validity...
January 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28101728/implementation-of-an-evidence-based-biobehavioral-treatment-for-cancer-patients
#5
Marlena M Ryba, Brittany M Brothers, Barbara L Andersen
One aim of dissemination and implementation (DI) research is to study the translation of evidence-based treatments (EBTs) from the research environments of their development and testing to broader communities where they are needed. There are few behavioral medicine DI studies and none in cancer survivorship. A determinant model (Setting, Therapist, Education, imPlementation, and Sustainability (STEPS)) was used to conceptualize DI of mental health treatment and frame a longitudinal study of implementation of a behavioral medicine EBT-a biobehavioral intervention (BBI) for cancer patients...
January 18, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28101373/optimizing-maternal-and-neonatal-outcomes-with-postpartum-contraception-impact-on-breastfeeding-and-birth-spacing
#6
REVIEW
Aparna Sridhar, Jennifer Salcedo
Postpartum contraception is important to prevent unintended pregnancies. Assisting women in achieving recommended inter-pregnancy intervals is a significant maternal-child health concern. Short inter-pregnancy intervals are associated with negative perinatal, neonatal, infant, and maternal health outcomes. More than 30% of women experience inter-pregnancy intervals of less than 18 months in the United States. Provision of any contraceptive method after giving birth is associated with improved inter-pregnancy intervals...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28100746/end-stopping-predicts-curvature-tuning-along-the-ventral-stream
#7
Carlos R Ponce, Till S Hartmann, Margaret S Livingstone
: Neurons in primate inferotemporal cortex (IT) are clustered into patches of shared image preferences. Functional imaging has shown that these patches are activated by natural categories (e.g., faces, body parts, and places), artificial categories (numerals, words) and geometric features (curvature and real-world size). These domains develop in the same cortical locations across monkeys and humans, which raises the possibility of common innate mechanisms. Although these commonalities could be high-level template-based categories, it is alternatively possible that the domain locations are constrained by low-level properties such as end-stopping, eccentricity, and the shape of the preferred images...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28098628/the-abcdef-bundle-science-and-philosophy-of-how-icu-liberation-serves-patients-and-families
#8
E Wesley Ely
Over the past 20 years, critical care has matured in a myriad of ways resulting in dramatically higher survival rates for our sickest patients. For millions of new survivors comes de novo suffering and disability called "the postintensive care syndrome." Patients with postintensive care syndrome are robbed of their normal cognitive, emotional, and physical capacity and cannot resume their previous life. The ICU Liberation Collaborative is a real-world quality improvement initiative being implemented across 76 ICUs designed to engage strategically the ABCDEF bundle through team- and evidence-based care...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28098227/adolescents-display-distinctive-tolerance-to-ambiguity-and-to-uncertainty-during-risky-decision-making
#9
Wouter van den Bos, Ralph Hertwig
Although actuarial data indicate that risk-taking behavior peaks in adolescence, laboratory evidence for this developmental spike remains scarce. One possible explanation for this incongruity is that in the real world adolescents often have only vague information about the potential consequences of their behavior and the likelihoods of those consequences, whereas in the lab these are often clearly stated. How do adolescents behave under such more realistic conditions of ambiguity and uncertainty? We asked 105 participants aged from 8 to 22 years to make three types of choices: (1) choices between options whose possible outcomes and probabilities were fully described (choices under risk); (2) choices between options whose possible outcomes were described but whose probability information was incomplete (choices under ambiguity), and (3) choices between unknown options whose possible outcomes and probabilities could be explored (choices under uncertainty)...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28089521/trends-in-naloxone-prescriptions-prescribed-after-implementation-of-a-national-academic-detailing-service-in-the-veterans-health-administration-a-preliminary-analysis
#10
Mark Bounthavong, Michael A Harvey, Daina L Wells, Sarah J Popish, Julianne Himstreet, Elizabeth M Oliva, Chad L Kay, Marcos K Lau, Priyanka P Randeria-Noor, Andrea G Phillips, Melissa L D Christopher
OBJECTIVES: To evaluate the effects of the U.S. Veterans Health Administration (VA) National Academic Detailing Service alongside the Opioid Overdose Education and Naloxone Distribution (OEND) program on naloxone prescriptions prescribed from October 2014 to September 2016. METHODS: A retrospective, repeated measures cohort study was conducted to evaluate the effectiveness of a real-world application of academic detailing (AD) alongside OEND on providers' outpatient naloxone prescribing from October 2014 to September 2016...
January 11, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28087465/are-cardiovascular-disease-risk-assessment-and-management-programmes-cost-effective-a-systematic-review-of-the-evidence
#11
REVIEW
John Tayu Lee, Kenny D Lawson, Yizhou Wan, Azeem Majeed, Stephen Morris, Michael Soljak, Christopher Millett
The World Health Organization recommends that countries implement population-wide cardiovascular disease (CVD) risk assessment and management programmes. The aim of this study was to conduct a systematic review to evaluate whether this recommendation is supported by cost-effectiveness evidence. Published economic evaluations were identified via electronic medical and social science databases (including Medline, Web of Science, and the NHS Economic Evaluation Database) from inception to March 2016. Study quality was evaluated using a modified version of the Consolidated Health Economic Evaluation Reporting Standards...
January 10, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28078644/eight-or-12-week-treatment-of-hepatitis-c-with-ledipasvir-sofosbuvir-real-world-experience-in-a-large-integrated-health-system
#12
Jennifer B Lai, Maxwell A Witt, Mary Patricia Pauly, Joanna Ready, Michael Allerton, Suk Seo, David J Witt
BACKGROUND: Second-generation direct-acting antiviral agents are integral to treatment of hepatitis C (HCV) infection. Eight-week courses of ledipasvir/sofosbuvir (LDV/SOF) have been supported in some studies, but data are limited on efficacy in real-world use. Controversy exists regarding applicability of clinical trials to real-world effectiveness. We report virologic responses of patients with HCV genotype 1 infection receiving LDV/SOF for 8 or 12 weeks in a large integrated healthcare system...
January 11, 2017: Drugs
https://www.readbyqxmd.com/read/28078541/glucagon-like-peptide-1-receptor-agonist-glp-1ra-therapy-adherence-for-patients-with-type-2-diabetes-in-a-medicare-population
#13
Hiep Nguyen, Robert Dufour, Amanda Caldwell-Tarr
INTRODUCTION: Anti-diabetes medication regimen adherence is a clinical challenge in elderly patients with type 2 diabetes (T2D) and other comorbidities associated with aging. Glucagon-like peptide-1 receptor agonists (GLP-1RA) therapies such as exenatide once weekly (QW), exenatide twice daily (BID), and liraglutide once daily (QD) are an increasingly used class of drugs with proven efficacy and tolerability. Real-world evidence on adherence to GLP-1RAs in elderly or disabled patients is limited...
January 11, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28076703/a-systematic-review-to-assess-the-adherence-and-persistence-with-statins
#14
Sohan Deshpande, Ruben G W Quek, Carol A Forbes, Shelley de Kock, Jos Kleijnen, Shravanthi R Gandra, Ross J Simpson
OBJECTIVE: To identify and assess studies published over a 10-year period up to February 2016 which measure adherence or persistence with statins, to summarise their methods, strengths and weaknesses and to summarise evidence linking statin adherence/persistence with risk of cardiovascular events. METHODS: Electronic databases and abstracts from four major cardiovascular disease conferences were searched from January 2005 to February 2016. The study selection process was performed by two reviewers working independently...
January 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28076667/effectiveness-of-antipsychotic-drugs-for-24-month-maintenance-treatment-in-first-episode-schizophrenia-evidence-from-a-community-based-real-world-study
#15
Chen Zhang, Mei-Juan Chen, Guo-Jun Wu, Zuo-Wei Wang, Shun-Zeng Rao, Yi Zhang, Zheng-Hui Yi, Wei-Min Yang, Ke-Ming Gao, Li-Sheng Song
OBJECTIVE: Maintenance treatment of schizophrenia with antipsychotic medications has become a standard for the prevention of psychotic relapse. However, little is known about the effectiveness of antipsychotic drugs for maintenance treatment in "real-world" populations with schizophrenia. We carried out a prospective study to assess the effectiveness of the most frequently prescribed antipsychotic drugs in the maintenance treatment of schizophrenia from 2 community settings. METHODS: This study was conducted from October 2011 to December 2014...
November 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28073791/rapid-deployment-aortic-replacement-radar-registry-in-spain-a-protocol
#16
Victor Bautista-Hernandez, Natalia Cal-Purriños, Jose M Arribas-Leal, Manuel Carnero-Alcazar, Jose F Gutierrez-Diez, Jose J Cuenca-Castillo
INTRODUCTION: Rapid deployment valves (RDV) represent a newly introduced approach to aortic valve replacement which facilitates surgical implantation and minimally invasive techniques, shortens surgical times and shows excellent haemodynamic performance. However, evidence on their safety, efficacy and potential complications is mostly fitted with small-volume and retrospective studies. Moreover, no current guidelines exist. To improve our knowledge on this technology, The Rapid Deployment Aortic Replacement (RADAR) Registry will be established across Spain with the aim of assessing RDV outcomes in the real-world setting...
January 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28073041/major-depressive-disorder-with-subthreshold-hypomanic-mixed-features-a-real-world-assessment-of-treatment-patterns-and-economic-burden
#17
Roger S McIntyre, Daisy Ng-Mak, Chien-Chia Chuang, Rachel Halpern, Pankaj A Patel, Krithika Rajagopalan, Antony Loebel
BACKGROUND: To compare outcomes for individuals with major depressive disorder (MDD) with or without subthreshold hypomania (mixed features) in naturalistic settings. METHODS: Using the Optum Research Database (1/1/2009─10/31/2014), a retrospective analysis of individuals newly diagnosed with MDD was conducted. Continuous enrollment for 12-months before and after the initial MDD diagnosis was required. MDD with subthreshold hypomania (mixed features) (MDD-MF) was defined based on ≥1 hypomania diagnosis within 30 days after an MDD diagnosis during the one-year follow-up period, in the absence of bipolar I diagnoses...
December 23, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28069650/evidence-to-support-continuation-of-statin-therapy-in-patients-with-staphylococcus-aureus-bacteremia
#18
Aisling R Caffrey, Tristan T Timbrook, Eunsun Noh, George Sakoulas, Steven M Opal, Victor Nizet, Kerry L LaPlante
In addition to cholesterol lowering capabilities, statins possess antiinflammatory and immunomodulatory effects. We sought to quantify the real-world impact of different statin exposure patterns on clinical outcomes in Staphylococcus aureus bacteremia. We conducted a retrospective cohort study among hospitalized patients with positive S. aureus blood cultures receiving appropriate antibiotics within 48 hours of culture collection (Veterans Affairs hospitals, 2002-2013). Three statin exposure groups were compared to non-users: pretreated statin users initiating therapy in the 30 days prior to culture and either (1) continuing statin therapy after culture, or (2) not continuing after culture, and (3) de novo users initiating at culture...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28068138/payment-reform-in-the-patient-centered-medical-home-enabling-and-sustaining-integrated-behavioral-health-care
#19
Benjamin F Miller, Kaile M Ross, Melinda M Davis, Stephen P Melek, Roger Kathol, Patrick Gordon
The patient-centered medical home (PCMH) is a promising framework for the redesign of primary care and more recently specialty care. As defined by the Agency for Healthcare Research and Quality, the PCMH framework has 5 attributes: comprehensive care, patient-centered care, coordinated care, accessible services, and quality and safety. Evidence increasingly demonstrates that for the PCMH to best achieve the Triple Aim (improved outcomes, decreased cost, and enhanced patient experience), treatment for behavioral health (including mental health, substance use, and life stressors) must be integrated as a central tenet...
January 2017: American Psychologist
https://www.readbyqxmd.com/read/28065252/additional-real-world-evidence-supporting-procalcitonin-as-an-effective-tool-to-improve-antibiotic-management-and-cost-of-the-critically-ill-patient
#20
EDITORIAL
Philipp Schuetz, Peter M Wahl
No abstract text is available yet for this article.
January 2017: Chest
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