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https://www.readbyqxmd.com/read/28346821/structure-activity-relationships-on-cynnamoyl-derivatives-as-inhibitors-of-p300-histone-acetyltransferase
#1
Valentina Noemi Madia, Rosaria Benedetti, Maria Letizia Barreca, Liza Ngo, Luca Pescatori, Antonella Messore, Giovanni Pupo, Francesco Saccoliti, Sergio Valente, Antonello Mai, Luigi Scipione, Yujun George Zheng, Cristina Tintori, Maurizio Botta, Violetta Cecchetti, Lucia Altucci, Roberto Di Santo, Roberta Costi
Human p300 is a polyhedric transcriptional coactivator, playing a crucial role by acetylating histones on specific lysine residues. A great deal of evidences shows that p300 is involved in several diseases as leukemia, tumors and viral infection. Its involvement in pleiotropic biological roles and connections to diseases provide the rationale as to how its modulation could represent an amenable drug target. Several p300 inhibitors (HATi) have been described so far, but all suffer from low potency, lack of specificity or low cell-permeability, highlighting the need to find more effective inhibitors...
March 27, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28345917/enantiodivergent-synthesis-of-tertiary-%C3%AE-aryl-1-indanones-evidence-toward-disparate-mechanisms-in-the-palladium-catalyzed-decarboxylative-asymmetric-protonation
#2
Cian Kingston, Patrick J Guiry
Herein, we describe a study into the scope and origin of an enantiodivergent effect in the palladium-catalyzed decarboxylative asymmetric protonation. By switching the achiral proton source, both enantiomers of a series of tertiary α-aryl-1-indanones are readily accessed from the corresponding α-aryl-β-keto allyl esters. In this example of dual stereocontrol, enantioselectivities up to 94% (S) and 92% (R) were achieved using Meldrum's acid and formic acid, respectively. In an attempt to rationalize this switch in absolute configuration an investigation of the ambiguous mechanism of the decarboxylative asymmetric protonation was conducted...
March 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28345035/terrestrial-support-of-lake-food-webs-synthesis-reveals-controls-over-cross-ecosystem-resource-use
#3
Andrew J Tanentzap, Brian W Kielstra, Grace M Wilkinson, Martin Berggren, Nicola Craig, Paul A Del Giorgio, Jonathan Grey, John M Gunn, Stuart E Jones, Jan Karlsson, Christopher T Solomon, Michael L Pace
Widespread evidence that organic matter exported from terrestrial into aquatic ecosystems supports recipient food webs remains controversial. A pressing question is not only whether high terrestrial support is possible but also what the general conditions are under which it arises. We assemble the largest data set, to date, of the isotopic composition (δ(2)H, δ(13)C, and δ(15)N) of lake zooplankton and the resources at the base of their associated food webs. In total, our data set spans 559 observations across 147 lakes from the boreal to subtropics...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28344547/app-function-and-lipids-a-bidirectional-link
#4
REVIEW
Marcus O W Grimm, Janine Mett, Heike S Grimm, Tobias Hartmann
Extracellular neuritic plaques, composed of aggregated amyloid-β (Aβ) peptides, are one of the major histopathological hallmarks of Alzheimer's disease (AD), a progressive, irreversible neurodegenerative disorder and the most common cause of dementia in the elderly. One of the most prominent risk factor for sporadic AD, carrying one or two aberrant copies of the apolipoprotein E (ApoE) ε4 alleles, closely links AD to lipids. Further, several lipid classes and fatty acids have been reported to be changed in the brain of AD-affected individuals...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28342661/climate-change-and-human-infectious-diseases-a-synthesis-of-research-findings-from-global-and-spatio-temporal-perspectives
#5
Lu Liang, Peng Gong
The life cycles and transmission of most infectious agents are inextricably linked with climate. In spite of a growing level of interest and progress in determining climate change effects on infectious disease, the debate on the potential health outcomes remains polarizing, which is partly attributable to the varying effects of climate change, different types of pathogen-host systems, and spatio-temporal scales. We summarize the published evidence and show that over the past few decades, the reported negative or uncertain responses of infectious diseases to climate change has been growing...
March 22, 2017: Environment International
https://www.readbyqxmd.com/read/28342618/a-realist-synthesis-of-social-connectivity-interventions-during-transition-to-parenthood-the-value-of-relationships
#6
Claudine T Bennett, Judy L Buchan, Nicole Letourneau, Stuart G Shanker, Anne Fenwick, Brenda Smith-Chant, Cyndi Gilmer
BACKGROUND: Social connections are important during the transition to parenthood. A wide body of literature suggests that these connections enhance health and contribute to wellbeing. In the case of parents and families, social connections can influence child development. Nurses and public health agencies are in a unique position to advocate for resources and approaches to enhance social connectivity for parents during this important life transition. OBJECTIVES: The aim of this review was to identify the universal social connectivity interventions that work, and the conditions that foster social connections for parents and enhance child development...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28342018/overexpression-of-osgata12-regulates-chlorophyll-content-delays-plant-senescence-and-improves-rice-yield-under-high-density-planting
#7
Guangwen Lu, José A Casaretto, Shan Ying, Kashif Mahmood, Fang Liu, Yong-Mei Bi, Steven J Rothstein
Agronomic traits controlling the formation, architecture and physiology of source and sink organs are main determinants of rice productivity. Semi-dwarf rice varieties with low tiller formation but high seed production per panicle and dark green and thick leaves with prolonged source activity are among the desirable traits to further increase the yield potential of rice. Here, we report the functional characterization of a zinc finger transcription factor, OsGATA12, whose overexpression causes increased leaf greenness, reduction of leaf and tiller number, and affects yield parameters...
March 24, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28338602/design-and-synthesis-of-novel-pyrazole-substituted-different-nitrogenous-heterocyclic-ring-systems-as-potential-anti-inflammatory-agents
#8
Eman S Nossier, Hoda H Fahmy, Nagy M Khalifa, Wafaa I El-Eraky, Marawan A Baset
With the aim of developing novel anti-inflammatory scaffolds, a new series of pyrazole-substituted various nitrogenous heterocyclic ring systems at C-4 position were synthesized through different chemical reactions and validated by means of spectral and elemental data. The new obtained compounds were investigated for their anti-inflammatory activity using the carrageenan-induced paw edema standard technique and revealed that, compound 6b showed increased potency with % inhibition of edema 85.23 ± 1.92 and 85...
March 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28338062/coexistence-of-superconductivity-and-charge-density-wave-in-the-quasi-one-dimensional-material-hfte3
#9
Saleem J Denholme, Akinori Yukawa, Kohei Tsumura, Masanori Nagao, Ryuji Tamura, Satoshi Watauchi, Isao Tanaka, Hideaki Takayanagi, Nobuaki Miyakawa
We present the first experimental evidence for metallicity, superconductivity (SC) and the co-existence of charge density waves (CDW) in the quasi-one-dimensional material HfTe3. The existence of such phenomena is a typical characteristic of the transition metal chalcogenides however, without the application of hydrostatic pressure/chemical doping, it is rare for a material to exhibit the co-existence of both states. Materials such as HfTe3 can therefore provide us with a unique insight into the relationship between these multiple ordered states...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337985/synthesis-and-reactivity-of-a-mononuclear-non-haem-cobalt-iv-oxo-complex
#10
Bin Wang, Yong-Min Lee, Woon-Young Tcho, Samat Tussupbayev, Seoung-Tae Kim, Yujeong Kim, Mi Sook Seo, Kyung-Bin Cho, Yavuz Dede, Brenna C Keegan, Takashi Ogura, Sun Hee Kim, Takehiro Ohta, Mu-Hyun Baik, Kallol Ray, Jason Shearer, Wonwoo Nam
Terminal cobalt(IV)-oxo (Co(IV)-O) species have been implicated as key intermediates in various cobalt-mediated oxidation reactions. Herein we report the photocatalytic generation of a mononuclear non-haem [(13-TMC)Co(IV)(O)](2+) (2) by irradiating [Co(II)(13-TMC)(CF3SO3)](+) (1) in the presence of [Ru(II)(bpy)3](2+), Na2S2O8, and water as an oxygen source. The intermediate 2 was also obtained by reacting 1 with an artificial oxidant (that is, iodosylbenzene) and characterized by various spectroscopic techniques...
March 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28337890/beneficial-effects-of-protein-hydrolysates-in-exercise-and-sports-nutrition
#11
J Yuan, B Jiang, K Li, W Shen, J L Tang
Protein hydrolysates (PH) are rich sources of proteins that supply the need of exercising muscles. PHs are enriched in di- and tripeptides and are better than free amino acids or intact proteins when muscle anabolic effect is considered. Digestion, absorption and muscle uptake of amino acids are faster and more efficient when PH is ingested in comparison to the respective intact protein. PHs not only enhance endurance in high intensity exercise regimen, but also help in faster post-exercise recovery of muscle by promoting glycogen synthesis, although the latter effect requires more convincing evidence...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337803/synthesis-electronic-structure-and-reactivities-of-two-sulfur-stabilized-carbones-exhibiting-four-electron-donor-ability
#12
Tomohito Morosaki, Ryo Iijima, Tsubasa Suzuki, Wei-Wei Wang, Shigeru Nagase, Takayoshi Fujii
Bis(sulfane)carbon(0) (BSC; Ph2S→C←SPh2 (1)) is successfully synthesized by deprotonation of the corresponding protonated salt 1·HTfO. The diprotonated salt 1·(HTfO)2 as the starting material can be also easily accessed by the deimination of iminosulfane(sulfane)carbon(0) (iSSC)·HBF4. Density functional theory calculations revealed the peculiar electronic structure of 1 having two lone pairs of electrons at the central carbon atom. The largest proton affinities (PA(1): 297.5 kcal mol-1; PA(2) 183.7 kcal mol-1) and the highest energy levels of the HOMOs (HOMO: -4...
March 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28337244/rat-liver-enzyme-release-depends-on-blood-flow-bearing-physical-forces-acting-in-endothelium-glycocalyx-rather-than-on-liver-damage
#13
Julieta A Díaz-Juárez, Rolando Hernández-Muñoz
We have found selective elevation of serum enzyme activities in rats subjected to partial hepatectomy (PH), apparently controlled by hemodynamic flow-bearing physical forces. Here, we assess the involvement of stretch-sensitive calcium channels and calcium mobilization in isolated livers, after chemical modifications of the endothelial glycocalyx and changing perfusion directionality. Inhibiting in vivo protein synthesis, we found that liver enzyme release is influenced by de novo synthesis of endothelial glycocalyx components, and released enzymes are confined into a liver "pool...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28337182/new-insights-into-the-anti-pathogenic-potential-of-lactococcus-garvieae-against-staphylococcus-aureus-based-on-rna-sequencing-profiling
#14
Pierre Delpech, Etienne Rifa, Graham Ball, Sabine Nidelet, Emeric Dubois, Geneviève Gagne, Marie-Christine Montel, Céline Delbès, Stéphanie Bornes
The bio-preservation potential of Lactococcus garvieae lies in its capacity to inhibit the growth of staphylococci, especially Staphylococcus aureus, in dairy products and in vitro. In vitro, inhibition is modulated by the level of aeration, owing to hydrogen peroxide (H2O2) production by L. garvieae under aeration. The S. aureus response to this inhibition has already been studied. However, the molecular mechanisms of L. garvieae underlying the antagonism against S. aureus have never been explored. This study provides evidence of the presence of another extracellular inhibition effector in vitro...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28336840/spectroscopic-characterization-of-copper-chitosan-nanoantimicrobials-prepared-by-laser-ablation-synthesis-in-aqueous-solutions
#15
Maria Chiara Sportelli, Annalisa Volpe, Rosaria Anna Picca, Adriana Trapani, Claudio Palazzo, Antonio Ancona, Pietro Mario Lugarà, Giuseppe Trapani, Nicola Cioffi
Copper-chitosan (Cu-CS) nanoantimicrobials are a novel class of bioactive agents, providing enhanced and synergistic efficiency in the prevention of biocontamination in several application fields, from food packaging to biomedical. Femtosecond laser pulses were here exploited to disrupt a Cu solid target immersed into aqueous acidic solutions containing different CS concentrations. After preparation, Cu-CS colloids were obtained by tuning both Cu/CS molar ratios and laser operating conditions. As prepared Cu-CS colloids were characterized by Fourier transform infrared spectroscopy (FTIR), to study copper complexation with the biopolymer...
December 30, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335806/effectiveness-of-early-interventions-for-parental-sensitivity-following-preterm-birth-a-systematic-review-protocol
#16
Andréane Lavallée, Marilyn Aita, Anne Bourbonnais, Gwenaëlle De Clifford-Faugère
BACKGROUND: Parental sensitivity is the interaction process by which parents (a) recognize cues from their infant, (b) interpret these cues adequately, (c) identify an appropriate response and (d) apply this response in an appropriate time frame. In the neonatal intensive care unit, parents of preterm infants often encounter factors hampering the establishment of their parental sensitivity. Parents report the need to be in proximity to and to participate in their preterm infant's care in order to develop their sensitivity to their newborn infant...
March 23, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28335799/convergent-and-sequential-synthesis-designs-implications-for-conducting-and-reporting-systematic-reviews-of-qualitative-and-quantitative-evidence
#17
Quan Nha Hong, Pierre Pluye, Mathieu Bujold, Maggy Wassef
BACKGROUND: Systematic reviews of qualitative and quantitative evidence can provide a rich understanding of complex phenomena. This type of review is increasingly popular, has been used to provide a landscape of existing knowledge, and addresses the types of questions not usually covered in reviews relying solely on either quantitative or qualitative evidence. Although several typologies of synthesis designs have been developed, none have been tested on a large sample of reviews. The aim of this review of reviews was to identify and develop a typology of synthesis designs and methods that have been used and to propose strategies for synthesizing qualitative and quantitative evidence...
March 23, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28335734/evaluation-of-amstar-to-assess-the-methodological-quality-of-systematic-reviews-in-overviews-of-reviews-of-healthcare-interventions
#18
Michelle Pollock, Ricardo M Fernandes, Lisa Hartling
BACKGROUND: Overviews of reviews (overviews) compile information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for decision-making. It is recommended that authors assess and report the methodological quality of SRs in overviews-for example, using A MeaSurement Tool to Assess systematic Reviews (AMSTAR). Currently, there is variation in whether and how overview authors assess and report SR quality, and limited guidance is available. Our objectives were to: examine methodological considerations involved in using AMSTAR to assess the quality of Cochrane and non-Cochrane SRs in overviews of healthcare interventions; identify challenges (and develop potential decision rules) when using AMSTAR in overviews; and examine the potential impact of considering methodological quality when making inclusion decisions in overviews...
March 23, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28335546/dietary-protein-and-amino-acid-supplementation-in-inflammatory-bowel-disease-course-what-impact-on-the-colonic-mucosa
#19
REVIEW
Sandra Vidal-Lletjós, Martin Beaumont, Daniel Tomé, Robert Benamouzig, François Blachier, Annaïg Lan
Inflammatory bowel diseases (IBD), after disease onset, typically progress in two cyclically repeated phases, namely inflammatory flare and remission, with possible nutritional status impairment. Some evidence, either from epidemiological, clinical, and experimental studies indicate that the quantity and the quality of dietary protein consumption and amino acid supplementation may differently influence the IBD course according to the disease phases. For instance, although the dietary protein needs for mucosal healing after an inflammatory episode remain undetermined, there is evidence that amino acids derived from dietary proteins display beneficial effects on this process, serving as building blocks for macromolecule synthesis in the wounded mucosal area, energy substrates, and/or precursors of bioactive metabolites...
March 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28334801/a-systematic-review-of-the-physical-activity-assessment-tools-used-in-primary-care
#20
Toby O Smith, Máire C McKenna, Charlotte Salter, Wendy Hardeman, Kathryn Richardson, Melvyn Hillsdon, Carly A Hughes, Nicholas Steel, Andy P Jones
Background.: Primary care is an ideal setting for physical activity interventions to prevent and manage common long-term conditions. To identify those who can benefit from such interventions and to deliver tailored support, primary care professionals (e.g. GPs, practice nurses, physiotherapists, health care assistants) need reliable and valid tools to assess physical activity. However, there is uncertainty about the best-performing tool. Objective.: To identify the tools used in the literature to assess the physical activity in primary care and describe their psychometric properties...
February 21, 2017: Family Practice
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