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https://www.readbyqxmd.com/read/29240566/a-practical-clinical-approach-to-utilize-cardiopulmonary-exercise-testing-in-the-evaluation-and-management-of-coronary-artery-disease-a-primer-for-cardiologists
#1
Sundeep Chaudhry, Ross Arena, Deepak L Bhatt, Subodh Verma, Naresh Kumar
PURPOSE OF REVIEW: There is growing clinical interest for the use of cardiopulmonary exercise testing (CPET) to evaluate patients with or suspected coronary artery disease (CAD). With mounting evidence, this concise review with relevant teaching cases helps to illustrate how to integrate CPET data into real world patient care. RECENT FINDINGS: CPET provides a novel and purely physiological basis to identify cardiac dysfunction in symptomatic patients with both obstructive-CAD and nonobstructive-CAD (NO-CAD)...
December 13, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29240293/transvenous-pacemaker-implantation-after-the-bidirectional-glenn-operation-for-patients-with-complex-congenital-disease
#2
Danielle E Harake, Kevin M Shannon, Jamil A Aboulhosn, Jeremy P Moore
INTRODUCTION: The bidirectional Glenn operation for congenital heart disease produces anatomical constraints to conventional transvenous pacemaker implantation. An iliac approach, although not previously described in this population, is potentially a preferable alternative to a thoracotomy for epicardial pacing. METHODS AND RESULTS: A single-center retrospective review was performed for all patients that underwent transvenous pacemaker implantation following the bidirectional Glenn operation with partial biventricular repair...
December 14, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29240004/synchronizing-gait-with-cardiac-cycle-phase-alters-heart-rate-response-during-running
#3
Keren Constantini, Abigail S L Stickford, Jeffery L Bleich, Paul D Mannheimer, Benjamin D Levine, Robert F Chapman
Timing foot strike to occur in synchrony with cardiac diastole may reduce left ventricular afterload and promote coronary and skeletal muscle perfusion. PURPOSE: To assess heart rate (HR) and metabolic responses to running when foot strikes are timed to occur exclusively during 1) the systolic phase of the cardiac cycle, or 2) the diastolic phase. METHODS: Ten elite male distance runners performed a testing session on a treadmill at 4.72 m[BULLET OPERATOR]s while matching their steps to an auditory tone and wearing a chest strap that transmitted accelerometer and ECG signals...
December 12, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29239338/effects-of-neuregulin-1-on-autonomic-nervous-system-remodeling-post-myocardial-infarction-in-a-rat-model
#4
Xin Lai, Liang Zhong, Hai-Xia Fu, Song Dang, Xin Wang, Ning Zhang, Gao-Ke Feng, Zi-Qiang Liu, Xi Wang, Long Wang
Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocardial infarction (MI). Increasing evidence indicates that neuregulin-1 (NRG-1) improves cardiac function following heart failure. Since its impact on cardiac function and neural remodeling post-MI is poorly understood, we aimed to investigate the role of NRG-1 in autonomic nervous system remodeling post-MI. Forty-five Sprague-Dawley rats were equally randomized into three groups: sham (with the left anterior descending coronary artery exposed but without ligation), MI (left anterior descending coronary artery ligation), and MI plus NRG-1 (left anterior descending coronary artery ligation followed by intraperitoneal injection of NRG-1 (10 μg/kg, once daily for 7 days))...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29238609/blunted-heart-rate-recovery-is-associated-with-coronary-artery-spasm-in-patients-with-suspected-vasospastic-angina
#5
Hyunsu Kim, Sang-Hoon Cho, Kyoung-Im Cho, Bong-Joon Kim, Sung-Il Im, Jung-Ho Heo
Background: Autonomic nervous system activity has been shown to be altered in patients with vasospastic angina (VA). Heart rate recovery (HRR) is a simple, non-invasive measurement of autonomic nervous system dysfunction. We aimed to investigate whether HRR is related to VA, as established by an ergonovine test. Methods: A total of 976 consecutive patients (47.5% male, mean age 55 years) without significant coronary artery disease who underwent both an ergonovine provocation test and a treadmill exercise test were enrolled...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29238500/effects-of-dexmedetomidine-on-heart-arrhythmia-prevention-in-off-pump-coronary-artery-bypass-surgery-a-randomized-clinical-trial
#6
Ghasem Soltani, Saeed Jahanbakhsh, Mohammad Abbasi Tashnizi, Mehdi Fathi, Shahram Amini, Nahid Zirak, Shima Sheybani
Background: Arrhythmia occurring during and after surgery is one of the major complications in open-heart surgery. Dexmedetomidine is an intravenous alpha-2 agonist and very specific short-acting drug to protect the various organs against ischemic injuries and blood reflow. However, the effect of dexmedetomidine for preventing intraoperative heart arrhythmias has not been recognized. Objective: This study aimed to determine the effect of dexmedetomidine on the incidence rate of heart arrhythmias and anesthetic required in off-pump coronary artery bypass surgery...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238430/safety-of-landiolol-hydrochloride-as-a-premedication-for-producing-an-appropriate-heart-rate-for-multidetector-row-computed-tomography-coronary-angiography
#7
Rie Koyoshi, Yuhei Shiga, Yoshiaki Idemoto, Yoko Ueda, Kohei Tashiro, Takashi Kuwano, Ken Kitajima, Kanta Fujimi, Akira Kawamura, Masahiro Ogawa, Shin-Ichiro Miura
Background: We evaluated the safety of a bolus injection of landiolol hydrochloride, an ultrashort-acting β1-selective antagonist, as a premedication prior to multidetector-row computed tomography coronary angiography (CTA). Methods: The subjects consisted of 176 patients (M/F = 64:112, 67 ± 11 years) who had heart rate (HR) at rest ≥ 70 beats/min (bpm) and underwent CTA. Systolic/diastolic blood pressure (SBP/DBP) and HR were measured before and after the administration of landiolol...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29237548/dietary-patterns-and-the-risk-of-coronary-heart-disease-among-jordanians-a-case-control-study
#8
R F Tayyem, A E Al-Shudifat, A Johannessen, H A Bawadi, S S AbuMweis, L M Agraib, S S Allhedan, I Haj-Husein, M Azab
BACKGROUND AND AIMS: Dietary pattern and lifestyle have been reported to be significant risk factors in the development of coronary heart diseases (CHD). The contribution degree of these dietary risk factors in CHD development in non-westernized countries is unclear. This study aimed to evaluate several dietary choices and their potential association with CHD. METHODS AND RESULTS: A case-control study was conducted at Prince Hamza Hospital, a referral center for coronary angiography in Amman, Jordan...
November 8, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29237243/exercise-related-severe-cardiac-events
#9
Lourdes Vicent, Albert Ariza-Solé, José Ramón González-Juanatey, Aitor Uribarri, José Ortiz, Esteban López de Sá, Jordi Sans-Roselló, Carlos Tomás Querol, Pau Codina, Iago Sousa-Casasnovas, Manuel Martínez-Sellés
BACKGROUND: Physical activity has benefits on health. However, there is a small risk of effort-related adverse events. The aim of this study is to describe exercise-related severe cardiovascular events and to relate them with the type of sport performed. METHODS: Ten-year retrospective study in 8 Spanish cardiac intensive care units. Adverse cardiac events were defined as acute myocardial infarction, cardiac arrest, or syncope related to physical activity. RESULTS: From 117 patients included, 109 were male (93...
December 13, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29237156/potential-involvement-of-mir-30e-3p-in-myocardial-injury-induced-by-coronary-microembolization-via-autophagy-activation
#10
Xian-Tao Wang, Xiao-Dan Wu, Yuan-Xi Lu, Yu-Han Sun, Han-Hua Zhu, Jia-Bao Liang, Wen-Kai He, Zhi-Yu Zeng, Lang Li
BACKGROUND/AIMS: Coronary microembolization (CME) can lead to no-reflow or slow reflow, which is one of the important reasons for loss of clinical benefit from myocardial reperfusion therapy. MicroRNAs and autophagy are heavily implicated in the occurrence and development of almost all cardiovascular diseases. Therefore, the present study was designed to investigate the role of miR-30e-3p and autophagy in CME-induced myocardial injury rat model. METHODS: Sixty rats were randomly divided into six groups: sham, CME 1h,3h,6h,9h, and 12h (n = 10 per group)...
December 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29236988/diagnostic-and-prognostic-value-of-myocardial-blood-flow-quantification-as-non-invasive-indicator-of-cardiac-allograft-vasculopathy
#11
Paco E Bravo, Brian A Bergmark, Tomas Vita, Viviany R Taqueti, Ankur Gupta, Sara Seidelmann, Thomas E Christensen, Michael T Osborne, Nishant R Shah, Nina Ghosh, Jon Hainer, Courtney F Bibbo, Meagan Harrington, Fred Costantino, Mandeep R Mehra, Sharmila Dorbala, Ron Blankstein, Akshay Desai, Lynne Stevenson, Michael M Givertz, Marcelo F Di Carli
Aims: Cardiac allograft vasculopathy (CAV) is a leading cause of death in orthotopic heart transplant (OHT) survivors. Effective non-invasive screening methods are needed. Our aim was to investigate the added diagnostic and prognostic value of myocardial blood flow (MBF) to standard myocardial perfusion imaging (MPI) with positron emission tomography (PET) for CAV detection. Methods and results: We studied 94 OHT recipients (prognostic cohort), including 66 who underwent invasive coronary angiography and PET within 1 year (diagnostic cohort)...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29236912/cardiorespiratory-performance-of-coronary-artery-disease-patients-on-land-versus-underwater-treadmill-tests-a-comparative-study
#12
Mauricio Koprowski Garcia, Limanara Rizzo, Paulo Yazbek-Júnior, Daniela Yutiyama, Fabiola Jomar da Silva, Denise Matheus, Luiz Eduardo Mastrocolla, Eduardo Massad
OBJECTIVE: To compare responses to a cardiopulmonary exercise test on land versus on an underwater treadmill, to assess the cardiorespiratory performance of coronary artery disease patients while immersed in warm water and to compare with the performance of healthy individuals. METHODS: The sample population consisted of 40 subjects, which included 20 coronary artery disease patients aged 63.7±8.89 years old, functional class I and II, according to the New York Hearth Association, and 20 healthy subjects aged 64...
November 2017: Clinics
https://www.readbyqxmd.com/read/29236149/transcatheter-aortic-valve-replacement-with-balloon-expandable-valve-analysis-of-initial-experience-in-china
#13
Y Shen, H Zhang, L Zhang, H Li, H Mao, Y Pei, Z Jing, Q Lu
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is widely applied for the treatment of severe aortic stenosis (AS) in developed countries; however, in China, it is still in the early stage of utilization. On the basis of previous studies, this work explored the feasibility of TAVR in patients with severe AS in China and analyzed the cause of death in four cases. METHODS: This retrospective study included 20 patients who had severe AS and underwent TAVR with a balloon-expandable system (Edwards SAPIEN XT) in our hospital from January 2011 to June 2016...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29235274/-identification-and-function-analysis-of-target-group-for-cardioprotection-of-baoyuan-decoction
#14
Yan-Jun Wan, Li-Xi Liao, Yu-Qi Liu, Yong Jiang, Lian-Ying Liu, Ke-Wu Zeng, Peng-Fei Tu
Baoyuan decoction (BYD) is a well-known traditional Chinese medicine formula for coronary heart disease with Qi deficiency. However, the detailed pharmacological mechanism of BYD is still unknown because of its complicated chemical compositions. In this study, we synthesized a kind of solid beads with benzophenone groups on its surface. Benzophenone can be activated and chemically cross-linked with the C-H bonds of the chemical compositions in BYD (BYD beads) under UV activation. We thus captured all the target proteins from mouse heart tissue lysates by using BYD beads...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235056/separating-arterial-pressure-increases-and-decreases-in-assessing-cardiac-baroreflex-sensitivity-via-sequence-and-bivariate-phase-rectified-signal-averaging-techniques
#15
Beatrice De Maria, Vlasta Bari, Marco Ranucci, Valeria Pistuddi, Giovanni Ranuzzi, Anielle C M Takahashi, Aparecida M Catai, Laura Dalla Vecchia, Sergio Cerutti, Alberto Porta
Cardiac baroreflex (cBR) is activated by both arterial pressure (AP) increases and decreases. Sequence method, a widely utilized tool assessing cBR sensitivity (cBRS) from spontaneous heart period (HP) and systolic AP (SAP) variations, allows the separated computation of cBRS from positive and negative SAP variations. The recently proposed phase-rectified signal averaging (PRSA) method has the same feature but it has been applied so far solely to positive SAP variations. We adapted the PRSA method to compute cBRS over negative SAP variations and we compared the results with those derived from sequence method over two protocols: (i) graded head-up tilt (HUT) at 15, 30, 45, 60, and 75° in 19 healthy subjects and (ii) general anesthesia induction in 118 patients undergoing coronary artery bypass graft surgery...
December 13, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29234814/hormone-therapy-for-the-primary-prevention-of-chronic-conditions-in-postmenopausal-women-us-preventive-services-task-force-recommendation-statement
#16
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Menopause occurs at a median age of 51.3 years, and the average US woman who reaches menopause is expected to live another 30 years. The prevalence and incidence of most chronic conditions, such as coronary heart disease, dementia, stroke, fractures, and breast cancer, increase with age; however, the excess risk for these conditions that can be attributed to menopause alone is uncertain. Since the publication of findings from the Women's Health Initiative that hormone therapy use is associated with serious adverse health effects in postmenopausal women, use of menopausal hormone therapy has declined...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234452/genetic-variations-of-cholesteryl-ester-transfer-protein-and-diet-interactions-in-relation-to-lipid-profiles-and-coronary-heart-disease-a-systematic-review
#17
REVIEW
Parvin Mirmiran, Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Gelareh Koochakpoor, Maryam S Daneshpour, Bahar Sedaghati-Khayat, Fereidoun Azizi
Data on diet-genotype interactions in the prevention or treatment of dyslipidemia have increased remarkably. This systematic review aimed to assess nutrigenetic studies regarding the modulating effect of diet on cholesteryl ester transfer protein (CETP) polymorphisms in relation to metabolic traits. Data were collected through studies published between 2000 and SEP. 2016 using five electronic databases. The quality of eligible studies was assessed using a 12-item quality checklist, derived from the STrengthening the REporting of Genetic Association Studies (STREGA) statement...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29233491/utility-of-myeloperoxidase-in-the-differential-diagnosis-of-acute-coronary-syndrome
#18
Pilar Calmarza, Carlos Lapresta, María Martínez, Raquel Lahoz, Javier Povar
OBJECTIVES: To determine the usefulness of myeloperoxidase in discriminating between patients with acute coronary syndrome and patients with chest pain by other causes. METHODS: The study included all patients over 18 years of age who come consecutively to the emergency department from September 2015 to December 2015 with chest pain of non-traumatic origin. The initial patient evaluation was performed according to the study protocol for patients with suspected acute coronary syndrome (ACS) in our Emergency Department...
December 7, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29233087/stroke-prevention-rehabilitation-intervention-trial-of-exercise-sprite-a-randomised-feasibility-study
#19
Neil Heron, Frank Kee, Jonathan Mant, Philip M Reilly, Margaret Cupples, Mark Tully, Michael Donnelly
BACKGROUND: The value of cardiac rehabilitation (CR) after a transient ischaemic attack (TIA) or minor stroke is untested despite these conditions sharing similar pathology and risk factors to coronary heart disease. We aimed to evaluate the feasibility of conducting a trial of an adapted home-based CR programme, 'The Healthy Brain Rehabilitation Manual', for patients following a TIA/minor stroke, participants' views on the intervention and, to identify the behaviour change techniques (BCTs) used...
December 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29233027/effects-of-phosphodiestrase-type-5-inhibitors-in-epinephrine-induced-arrhythmia-in-rats-involvement-of-lactate-dehydrogenase-and-creatine-kinase-downregulation-and-adiponectin-expression
#20
Aaa Salama, R E Mostafa, E A Omara
Cardiac arrhythmia is a common cause of mortality, and its progression may be due to abnormal sympathetic nerve activity and catecholamine release. Besides, lactate dehydrogenase (LDH) and creatine kinase (CK) downregulation and adiponectin expression play important roles in promoting coronary artery disease. The study aimed to examine the possible cardioprotective effect of members of phosphodiesterase type 5 (PDE-5) inhibitors in epinephrine-induced arrhythmia in rats. Arrhythmia was induced by cumulative boluses of epinephrine (4, 8, 16, 32, 64, and 128 mg/kg) given at 10-min intervals...
January 1, 2017: Human & Experimental Toxicology
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