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https://www.readbyqxmd.com/read/29684595/apelin-and-elabela-toddler-double-ligands-for-apj-apelin-receptor-in-heart-development-physiology-and-pathology
#1
Keiji Kuba, Teruki Sato, Yumiko Imai, Tomokazu Yamaguchi
Apelin is an endogenous peptide ligand for the G protein-coupled receptor APJ/AGTRL1/APLNR and is widely expressed throughout human body. In adult hearts Apelin-APJ/Apelin receptor axis is potently inotropic, vasodilatory, and pro-angiogenic and thereby contributes to maintaining homeostasis in normal and pathological hearts. Apelin-APJ/Apelin receptor is also involved in heart development including endoderm differentiation, heart morphogenesis, and coronary vascular formation. APJ/Apelin receptor had been originally identified as an orphan receptor for its sequence similarity to Angiotensin II type 1 receptor, and it was later deorphanized by identification of Apelin in 1998...
April 20, 2018: Peptides
https://www.readbyqxmd.com/read/29684507/angiotensin-ii-type-1a-receptors-in-the-subfornical-organ-modulate-neuroinflammation-in-the-hypothalamic-paraventricular-nucleus-in-heart-failure-rats
#2
Yang Yu, Shun-Guang Wei, Robert M Weiss, Robert B Felder
Inflammation in the hypothalamic paraventricular nucleus (PVN) contributes to neurohumoral excitation and its adverse consequences in systolic heart failure (HF). The stimuli that trigger inflammation in the PVN in HF are not well understood. Angiotensin II (AngII) has pro-inflammatory effects, and circulating levels of AngII increase in HF. The subfornical organ (SFO), a circumventricular structure that lacks an effective blood-brain barrier and senses circulating AngII, contains PVN-projecting neurons. We hypothesized that activation of AngII type 1a receptors (AT1a R) in the SFO induces neuroinflammation downstream in the PVN...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29684291/short-term-prediction-of-coronary-heart-disease-mortality-in-the-czech-republic-based-on-data-from-1968-2014
#3
Jindra Reissigová, Miroslav Zvolský
OBJECTIVES: The aim was to explore the patterns of the coronary heart disease (CHD) mortality rates over the past almost 50 years (1968-2014) in the Czech Republic, and to predict the mortality rates in 2015-2019. METHODS: The number of deaths from CHD and the population size were stratified by sex and age. The mortality rates were age-standardized to European population. Their values in 2015-2019 were estimated using the joinpoint log-linear regression, local log-linear regression and negative binomial log-linear regression, separately for males and females...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29683098/untargeted-metabolomics-in-the-discovery-of-novel-biomarkers-and-therapeutic-targets-for-atherosclerotic-cardiovascular-diseases
#4
Vi T Dang, Aric Huang, Geoff H Werstuck
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. Four out of five CVD deaths are due to myocardial infarction or stroke. Despite many initiatives that have been established for CVD prevention and risk management, and new therapies to treat existing CVD, patients continue to die from cardiac events. Clearly, we need to identify new therapeutic targets and strategies. Early diagnosis of CVDs and identification of patients at high risk of developing adverse events would allow for timely intervention that prevents serious consequences or death...
April 20, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29682783/optimized-respiratory-resolved-motion-compensated-3d-cartesian-coronary-mr-angiography
#5
Teresa Correia, Giulia Ginami, Gastão Cruz, Radhouene Neji, Imran Rashid, René M Botnar, Claudia Prieto
PURPOSE: To develop a robust and efficient reconstruction framework that provides high-quality motion-compensated respiratory-resolved images from free-breathing 3D whole-heart Cartesian coronary magnetic resonance angiography (CMRA) acquisitions. METHODS: Recently, XD-GRASP (eXtra-Dimensional Golden-angle RAdial Sparse Parallel MRI) was proposed to achieve 100% scan efficiency and provide respiratory-resolved 3D radial CMRA images by exploiting sparsity in the respiratory dimension...
April 22, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#6
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29681850/-tnfrsf12a-mediated-atherosclerosis-signaling-and-inflammatory-response-as-a-common-protection-mechanism-of-shuxuening-injection-against-both-myocardial-and-cerebral-ischemia-reperfusion-injuries
#7
Ming Lyu, Ying Cui, Tiechan Zhao, Zhaochen Ning, Jie Ren, Xingpiao Jin, Guanwei Fan, Yan Zhu
Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke and heart diseases and the underlying mechanisms remain unknown. Taking an integrated approach of RNA-seq and network pharmacology analysis, we compared transcriptome profiles of brain and heart ischemia reperfusion injury in C57BL/6J mice to identify common and differential target genes by SXNI. Models for myocardial ischemia reperfusion injury (MIRI) by ligating left anterior descending coronary artery (LAD) for 30 min ischemia and 24 h reperfusion and cerebral ischemia reperfusion injury (CIRI) by middle cerebral artery occlusion (MCAO) for 90 min ischemia and 24 h reperfusion were employed to identify the common mechanisms of SXNI on both cerebral and myocardial ischemia reperfusion...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681771/dosimetry-of-the-left-anterior-descending-coronary-artery-in-left-breast-cancer-patients-treated-with-postoperative-external-radiotherapy
#8
Adela Poitevin-Chacón, Jessica Chávez-Nogueda, Rubí Ramos Prudencio, Alejandro Calvo Fernández, Alejandro Rodríguez Laguna, Jesús Linares, Julio César Martínez
Aim: To evaluate the dose distribution to the left anterior descending (LAD) coronary artery in patients treated with postoperative three-dimensional conformal radiotherapy (3DCRT). Background: Postoperative radiotherapy may increase the risk of heart disease, particularly in patients with left-sided breast cancer. Clinical data on doses to the LAD are limited. Materials and methods: Retrospective study of 14 patients who underwent postoperative 3DCRT for left breast cancer in 2014...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29681329/expectation-focused-psychotherapy-to-improve-clinical-outcomes
#9
Bettina K Doering, Julia A Glombiewski, Winfried Rief
Placebo research has shown that patients' expectations are among the strongest predictors of treatment outcome regarding various medical conditions. Therefore, interventions focusing on the change of such expectations might be most effective. This could be of relevance not only for outcome expectations but also for disease-specific, problem-specific, and treatment-specific expectations. A theoretical model is introduced to illustrate the conditions for expectation change and persistence. Strategies for patients regarding how to devalue learning effects in expectation violation situations are exemplified, and ways to optimize expectation-violating effects are highlighted...
2018: International Review of Neurobiology
https://www.readbyqxmd.com/read/29680865/comparison-of-midterm-outcomes-of-transcatheter-aortic-valve-implantation-in-patients-with-and-without-previous-coronary-artery-bypass-grafting
#10
Hideyuki Kawashima, Yusuke Watanabe, Ken Kozuma, Akihisa Kataoka, Makoto Nakashima, Hirofumi Hioki, Fukuko Nagura, Yugo Nara, Shinichi Shirai, Norio Tada, Motoharu Araki, Toru Naganuma, Futoshi Yamanaka, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Akihiro Higashimori, Kensuke Takagi, Masanori Yamamoto, Kentaro Hayashida
The midterm safety and feasibility of transcatheter aortic valve implantation (TAVI) for patients with a history of coronary artery bypass graft (CABG) and high operative risk are unclear. This study compared the midterm outcomes of patients undergoing TAVI with or without previous CABG surgery. Between October 2013 and July 2016, 1,613 patients underwent TAVI according to the Optimized CathEter vAlvular iNtervention (OCEAN)-TAVI registry (previous CABG: n = 120; no previous CABG: n = 1493). The propensity score comprised the variables of the Society of Thoracic Surgeons Score, previous myocardial infarction, peripheral artery disease, chronic kidney disease > stage 2 (estimated glomerular filtration rate < 60 mL/min/1...
April 21, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29680826/inflammation-autophagy-and-apoptosis-after-myocardial-infarction
#11
Xianwei Wang, Zhikun Guo, Zufeng Ding, Jawahar L Mehta
BACKGROUND: There is evidence for inflammation, autophagy, and apoptosis in the ischemic heart. Autophagy is a physiologic process for tissue survival. Apoptosis, on the other hand, is a mechanism that serves to clear the debris in the setting of tissue injury. The balance between autophagy and apoptosis may be important in cell survival and cardiac function. METHODS AND RESULTS: We examined the interplay of inflammation and myocyte autophagy and apoptosis during the ischemic process...
April 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29680771/exercise-induced-left-bundle-branch-block-in-isotopic-exercise-test-findings-and-prognostic-value
#12
M V Gomez, B C Lorente Castro, P Jané, L García-Zoghby, A Martínez-Lorca, J A Pérez
INTRODUCTION: Exercise-induced left bundle branch block (EI-LBBB) is a rare circumstance of unknown significance. The purpose of this paper is to describe the scintigraphic features and the prognostic value of this finding. MATERIAL AND METHODS: We reviewed the features of 1,885 patients who had visited our department to undergo GATED-SPECT ergometry to diagnose ischaemic heart disease. Seven patients showed EI-LBBB throughout the exercise testing. Coronary angiography was performed in 4 of them...
April 18, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29680699/the-additive-effect-of-adherence-to-multiple-healthy-lifestyles-on-subclinical-atherosclerosis-insights-from-the-awhs
#13
Irina Uzhova, Rocio Mateo-Gallego, Belén Moreno-Franco, Esther Molina-Montes, Montserrat Leon-Latre, José A Casasnovas Lenguas, Fernando Civeira, José L Peñalvo
BACKGROUND: Public health strategies targeting multiple healthy behaviors, rather than individual factors, have been proposed as more efficient strategies to promote cardiovascular health. However, the additive effect of multiple targets on primary prevention has not been fully characterized. OBJECTIVE: To examine how adherence to multiple healthy behaviors is associated with the presence of subclinical atherosclerosis, a measure of early cardiovascular disease...
March 28, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29680403/formation-of-microcapsules-by-ultrasound-stimulation-for-use-in-remote-controlled-drug-eluting-stents
#14
Wei Yao, Yan Bao, Yu Chen
Coronary Heart Disease (CHD) is the leading cause of death globally. The placement of drug-eluting stents (DESs) in diseased coronary arteries is the most successful minimally-invasive intervention to treat CHD. The key limitations of such interventional therapy are the risk of in-stent restenosis (ISR) and late stent thrombosis. This paper investigates a new drug-release system by formatting nanoparticles as drug carriers, which are later subjected to an external ultrasonic stimulus for controlled drug release remotely for DESs...
April 18, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29680338/a-comparison-of-the-updated-diamond-forrester-cad-consortium-and-confirm-history-based-risk-scores-for-predicting-obstructive-coronary-artery-disease-in-patients-with-stable-chest-pain-the-scot-heart-coronary-cta-cohort
#15
Lohendran Baskaran, Ibrahim Danad, Heidi Gransar, Bríain Ó Hartaigh, Joshua Schulman-Marcus, Fay Y Lin, Jessica M Peña, Amanda Hunter, David E Newby, Philip D Adamson, James K Min
OBJECTIVES: This study sought to compare the performance of history-based risk scores in predicting obstructive coronary artery disease (CAD) among patients with stable chest pain from the SCOT-HEART study. BACKGROUND: Risk scores for estimating pre-test probability of CAD are derived from referral-based populations with a high prevalence of disease. The generalizability of these scores to lower prevalence populations in the initial patient encounter for chest pain is uncertain...
April 13, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29680298/experimental-evaluation-of-homemade-distal-stent-graft-fenestration-for-thoracic-endovascular-aortic-repair-of-type-a-dissection-by-a-transapical-approach
#16
Thomas Gandet, Anis Seghrouchni, Baris Ata Ozdemir, Guillaume Captier, Roland Demaria, Pierre Alric, Bernard Albat, Ludovic Canaud
OBJECTIVE: The use of off-the-shelf stent grafts for thoracic endovascular aortic repair of type A dissections is limited by variability in both the length of the ascending aorta and the location of the proximal intimal tear. This experimental study aimed to assess the feasibility of using a physician-modified thoracic aortic stent graft to treat acute type A dissection by a transapical cardiac approach. METHODS: The experiments were performed on six cadaveric human heart, ascending aorta, aortic arch, and descending aorta specimens...
April 18, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29680174/human-serum-albumin-in-cardiovascular-diseases
#17
REVIEW
Stephane Arques
Cardiovascular diseases are the leading cause of death worldwide. Endothelial dysfunction, inflammation and oxidative stress are at the forefront in the onset and development of atherosclerosis and many cardiovascular diseases. Epidemiological evidence is that low serum albumin levels are linked to incident ischemic heart disease, heart failure, atrial fibrillation, stroke and venous thromboembolism, independent of risk factors, body mass index and inflammation. Hypoalbuminemia has also emerged as an independent prognosticator in many cardiovascular diseases, such as coronary artery disease, heart failure, congenital heart disease, infective endocarditis and stroke, even after adjusting for usual causal factors and prognostic markers...
April 18, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29680172/optimal-timing-of-percutaneous-coronary-intervention-in-patients-with-non-st-segment-elevation-myocardial-infarction-complicated-by-acute-decompensated-heart-failure-from-the-korea-acute-myocardial-infarction-registry-national-institutes-of-health-kamir-nih
#18
Min Chul Kim, Myung Ho Jeong, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Tae Hoon Ahn, Ki Bae Seung, Dong-Joo Choi, Hyo-Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Kyung Kuk Hwang, Shung Chull Chae, Seung Ho Hur, Kwang Soo Cha, Seok Kyu Oh, Jei Keon Chae
The optimal timing of percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation myocardial infarction (NSTEMI), complicated by acute decompensated heart failure (ADHF), is unclear. A total of 1,027 patients with NSTEMI complicated by ADHF who underwent successful PCI were analyzed using a Korean multicenter registry. All patients were divided into 4 groups by the timing of PCI: group 1 (PCI < 2 hour after admission, n = 149), group 2 (2 to 24 hours, n = 577), group 3 (24 to 72 hours, n = 189), and group 4 (≥72 hours, n = 112)...
March 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29679418/family-involvement-in-rehabilitation-coronary-artery-disease-patients-perspectives
#19
Sonja Tuomisto, Meeri Koivula, Päivi Åstedt-Kurki, Mika Helminen
AIMS AND OBJECTIVES: The aim of this paper is to describe CAD -patients' perceptions of family involvement in rehabilitation and the connection between background factors and family involvement. BACKGROUND: CAD-patients hospital stays can be very concise. Family members can support rehabilitation, but many challenges can emerge. There is a need to nurture patients and family members in an individual way and to recognize their concerns. More accurate patient education should be available for patients and their family members...
April 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679294/gender-differences-in-home-based-cardiac-rehabilitation-of-post-percutaneous-coronary-intervention-patients
#20
Yong Hwan Kim, Wi-Young So
Cardiac rehabilitation (CR) is a structured program for the prevention of secondary cardiovascular disease (CVD) and related diseases, such as hypertension, diabetes, and obesity. This study aimed to investigate whether there are gender differences after 9 months of home-based cardiac rehabilitation program in post-percutaneous coronary intervention patients. A total of 114 (58.29 ± 10.33 years) men and 30 (60.90 ± 9.32 years) women were enrolled in the CR program. The program included three visits: initial, 4th month (follow-up), and 9th month (final) visits at a CR center...
April 20, 2018: Aging Clinical and Experimental Research
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