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https://www.readbyqxmd.com/read/28432673/prognostic-value-of-left-ventricular-dyssynchrony-evaluated-by-gated-myocardial-perfusion-imaging-in-patients-with-chronic-kidney-disease-and-normal-perfusion-defect-scores
#1
Hiroaki Mori, Satoshi Isobe, Susumu Suzuki, Kazumasa Unno, Ryota Morimoto, Naoaki Kano, Takahiro Okumura, Yoshinari Yasuda, Katsuhiko Kato, Toyoaki Murohara
BACKGROUND: This study aimed to investigate whether indices of left ventricular (LV) dyssynchrony by gated myocardial perfusion SPECT (GMPS) could be useful to predict prognosis in chronic kidney disease (CKD) patients with normal perfusion defect scores. METHODS: One hundred and sixty-seven CKD patients with normal perfusion defect scores on adenosine-stress (201)Tl GMPS and no previous history of overt heart diseases were enrolled. Phase standard deviation (PSD) and bandwidth (BW) were automatically calculated from GMPS...
April 21, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28432452/fluorescent-angioscopic-imaging-of-calcium-phosphate-tribasic-precursor-of-hydroxyapatite-the-major-calcium-deposit-in-human-coronary-plaques
#2
Takanobu Kobayashi, Osamu Nakagawa, Seiichiro Shirai, Ei Shimoyama, Nobuyuki Hiruta, Yasumi Uchida
Coronary calcification is a risk factor for ischemic heart disease. Hydroxyapatite that is formed by polymerization from calcium phosphate tribasic (CPT) is the major constituent of coronary calcium deposits. If CPT could be visualized, coronary calcification could be predicted and prevented. We discovered that when CPT and collagen I, the main constituent of collagen fibers, are mixed with lac dye (LD) and then exposed to fluorescent light excited at 345 ± 15 nm and emitted at 420 nm, a purple fluorescence that is characteristic of CPT only is elicited...
April 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28432434/ventricular-androgenic-anabolic-steroid-related-remodeling-an-immunohistochemical-study
#3
Rossana Cecchi, Barbara Muciaccia, Costantino Ciallella, Natale Mario Di Luca, Akihiko Kimura, Cristina Sestili, Mizuho Nosaka, Toshikazu Kondo
BACKGROUND: Several fatal cases of bodybuilders, following a myocardial infarction after long exposure to androgenic-anabolic steroids (AAS), are reported. In recent years, evidence has emerged of cases of heart failure related to AAS consumption, with no signs of coronary or aorta atherosclerosis. This study aims to further investigate the pathogenesis of the ventricular AAS-related remodeling performing immunohistochemistry (IHC). METHOD: In order to examine innate immunity activity and myocytes and endothelial cell apoptosis, IHC analyses were performed on heart tissue of two cases of bodybuilders who died after years of supratherapeutic use of metelonone and nandrolone and where no atherosclerosis or thrombosis were found, using the following antibodies: anti-CD68, anti-iNOS, anti-CD163, anti-CD 15, anti-CD8, anti-CD4, anti-HIF1 α, and in situ TUNEL staining...
April 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28431861/cardiac-computed-tomography-derived-myocardial-mass-at-risk-using-the-voronoi-based-segmentation-algorithm-a-histological-validation-study
#4
Seiko Ide, Satoru Sumitsuji, Osamu Yamaguchi, Yasushi Sakata
BACKGROUND: Myocardial mass at risk (MMAR) is an important predictor of adverse cardiac events in patients with ischemic heart disease. This study aims to validate the accuracy of MMAR calculated from cardiac computed tomography (CCT) data using the Voronoi-based segmentation algorithm in comparison with actual MMAR measured on ex-vivo swine hearts prepared by injecting a dye into the coronary arteries. METHODS: Fifteen extracted swine hearts had India ink injected into one of the major coronary arteries...
April 18, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28431474/previous-hypertensive-hemorrhage-increases-the-risk-for-bleeding-and-ischemia-for-pci-patients-on-dual-antiplatelet-therapy
#5
Manli Qiao, Qi Bi, Paul Fu, Yixin Wang, Zhe Song, Fang Guo
OBJECTIVES: The use of antiplatelet therapy after intracerebral hemorrhage remains controversial, while the use of dual antiplatelet therapy (DAPT) is required after cardiac stenting. In this study, we examine the risk of bleeding and ischemic events for PCI patients with a history of hypertensive hemorrhage on DAPT. METHODS: A total of 128 cases and 153 controls were selected from Chinese patients with cardiac stenting on dual anti-platelet therapy for a single-center retrospective case-control study...
April 21, 2017: Neurological Research
https://www.readbyqxmd.com/read/28431443/-surgical-and-interventional-therapy-of-mitral-valve-regurgitation
#6
Wolfgang Schillinger, Miriam Puls, Bernhard C Danner
Depending from the etiology of mitral valve pathology and surgical risk, mitral valve surgery is the therapy of choice for most degenerative mitral valve diseases. In isolated secondary mitral valve regurgitation, the indication for interventional or conservative therapy becomes more important. In severe left ventricular dysfunction heart transplantation has to be taken into consideration. If relevant coronary artery disease is present and bypass surgery is indicated, mitral valve surgery is mandatory in severe regurgitation and is subject to a benefit-risk evaluation in moderate regurgitation...
April 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28430962/ulk1-prevents-cardiac-dysfunction-in-obesity-through-autophagy-meditated-regulation-of-lipid-metabolism
#7
Minae An, Dong-Ryeol Ryu, Jang Won Park, Ji Ha Choi, Eun-Mi Park, Kyung Eun Lee, Minna Woo, Minsuk Kim
Aims: Autophagy is essential to maintain tissue homeostasis, particularly in long-lived cells such as cardiomyocytes. Whereas many studies support the importance of autophagy in the mechanisms underlying obesity-related cardiac dysfunction, the role of autophagy in cardiac lipid metabolism remains unclear. In the heart, lipotoxicity is exacerbated by cardiac lipoprotein lipase (LPL), which mediates accumulation of fatty acids to the heart through intravascular triglyceride (TG) hydrolysis...
April 17, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28430947/electrocardiographic-left-ventricular-hypertrophy-predicts-cardiovascular-morbidity-and-mortality-in-hypertensive-patients-the-allhat-study
#8
Casper N Bang, Elsayed Z Soliman, Lara M Simpson, Barry R Davis, Richard B Devereux, Peter M Okin
BACKGROUND: Electrocardiographic (ECG) left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular (CV) morbidity and mortality. However, the predictive value of ECG LVH in treated hypertensive patients remains unclear. METHODS: A total of 33,357 patients (aged ≥ 55 years) with hypertension and at least 1 other coronary heart disease (CHD) risk factor were randomized to chlorthalidone, amlodipine, or lisinopril. The outcome of the present study was all-cause mortality; and secondary endpoints were CHD, nonfatal myocardial infarction (MI), stroke, angina, heart failure (HF), and peripheral arterial disease...
April 19, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28430919/non-coding-rnas-in-cardiovascular-diseases-diagnostic-and-therapeutic-perspectives
#9
Wolfgang Poller, Stefanie Dimmeler, Stephane Heymans, Tanja Zeller, Jan Haas, Mahir Karakas, David-Manuel Leistner, Philipp Jakob, Shinichi Nakagawa, Stefan Blankenberg, Stefan Engelhardt, Thomas Thum, Christian Weber, Benjamin Meder, Roger Hajjar, Ulf Landmesser
Recent research has demonstrated that the non-coding genome plays a key role in genetic programming and gene regulation during development as well as in health and cardiovascular disease. About 99% of the human genome do not encode proteins, but are transcriptionally active representing a broad spectrum of non-coding RNAs (ncRNAs) with important regulatory and structural functions. Non-coding RNAs have been identified as critical novel regulators of cardiovascular risk factors and cell functions and are thus important candidates to improve diagnostics and prognosis assessment...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28430816/possible-increase-in-insulin-resistance-and-concealed-glucose-coupled-potassium-lowering-mechanisms-during-acute-coronary-syndrome-documented-by-covariance-structure-analysis
#10
Satoshi Ito, Tomohisa Nagoshi, Kosuke Minai, Yusuke Kashiwagi, Hiroshi Sekiyama, Akira Yoshii, Haruka Kimura, Yasunori Inoue, Kazuo Ogawa, Toshikazu D Tanaka, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura
OBJECTIVE: Although glucose-insulin-potassium (GIK) therapy ought to be beneficial for ischemic heart disease in general, variable outcomes in many clinical trials of GIK in acute coronary syndrome (ACS) had a controversial impact. This study was designed to examine whether "insulin resistance" is involved in ACS and to clarify other potential intrinsic compensatory mechanisms for GIK tolerance through highly statistical procedure. METHODS AND RESULTS: We compared the degree of insulin resistance during ACS attack and remission phase after treatment in individual patients (n = 104)...
2017: PloS One
https://www.readbyqxmd.com/read/28430815/soy-and-fish-as-features-of-the-japanese-diet-and-cardiovascular-disease-risks
#11
Yukio Yamori, Miki Sagara, Yoshimi Arai, Hitomi Kobayashi, Kazumi Kishimoto, Ikuko Matsuno, Hideki Mori, Mari Mori
In the World Health Organization (WHO)-coordinated Cardiovascular Disease and Alimentary Comparison Study, isoflavones (I; biomarker for dietary soy) and taurine (T; biomarker for dietary fish) in 24-hour-urine (24U) were inversely related to coronary heart disease (CHD) mortality. High levels of these biomarkers are found in Japanese people, whose CHD mortality is lowest among developed countries. We analyzed the association of these biomarkers with cardiovascular disease risk in the Japanese to know their health effects within one ethnic population...
2017: PloS One
https://www.readbyqxmd.com/read/28430633/association-between-coronary-heart-disease-and-erectile-dysfunction-in-chinese-han-population
#12
Guo-Xiang Tian, Sheng Li, Tong-Zu Liu, Xian-Tao Zeng, Wan-Lin Wei, Xing-Huan Wang
To investigate the association between coronary heart disease (CHD) and erectile dysfunction (ED) in Chinese Han population. Patients who went to the andrological out-patient clinic of our hospital between August 1, 2015 and May 1, 2016 and met all eligible criteria were enrolled in this study. The patients diagnosed as ED using self-administered International Index of Erectile Function-5 (IIEF-5) questionnaire were considered as case group and others were considered as control. The cases were categorized as mild, moderate, and severe ED...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430629/vascular-endothelial-growth-factor-a-polymorphisms-are-associated-with-increased-risk-of-coronary-heart-disease-a-meta-analysis
#13
Yafeng Wang, Qiuyu Huang, Jianchao Liu, Yanan Wang, Gongfeng Zheng, Ling Lin, Hui Yu, Weifeng Tang, Ziyang Huang
Coronary heart disease (CHD) is a common complex disease resulting from the interaction of multiple environmental and genetic factors. To assess the potential relationship of vascular endothelial growth factor (VEGFA) rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms with CHD risk, a comprehensive meta-analysis was conducted. A systematic search of EMBASE and PubMed online database for publications on VEGFA polymorphisms and risk of CHD was carried out. Crude Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated to determine the association...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429921/relationship-between-dietary-patterns-and-brachial-ankle-pulse-wave-velocity-among-middle-aged-adults-in-japan
#14
Shota Moyama, Kazuhiro Minami, Mihiro Yano, Masumi Okumura, Susumu Hayashi, Hiroshi Takayama, Akira Yorimoto
BACKGROUND AND OBJECTIVES: Arterial stiffness is a leading cause of cardiovascular disease (CVD), and it is considered to be affected by dietary intake. However, few studies have examined the relationship between major dietary patterns and brachial-ankle pulse wave velocity (baPWV) among Japanese middle-aged subjects. We studied whether major dietary patterns were associated with baPWV in this population. METHODS AND STUDY DESIGN: Between 2009 and 2012, 70 Japanese middle-aged subjects (39 men and 31 women) with no history of stroke, coronary heart disease, or cancer were studied...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429889/omentin-treatment-of-epicardial-fat-improves-its-anti-inflammatory-activity-and-paracrine-benefit-on-smooth-muscle-cells
#15
Ángel Fernández-Trasancos, Rosa María Agra, Jose María García-Acuña, Ángel Luis Fernández, José Ramón González-Juanatey, Sonia Eiras
OBJECTIVE: Epicardial adipose tissue (EAT) in coronary artery disease is insulin resistant and has a proinflammatory profile. This study examined the regulation of EAT by exogenous omentin and its consequence on vascular cells. METHODS: Stromal vascular cells (SC) of EAT and subcutaneous adipose tissue (SAT) from patients who underwent heart surgery were cultured and exposed to adipogenic factors with or without omentin. Proinflammatory cytokine regulation by omentin was analyzed in SC and mature adipocytes...
April 21, 2017: Obesity
https://www.readbyqxmd.com/read/28429212/experimental-study-of-a-radiopharmaceutical-agent-based-on-modified-fatty-acid-labeled-with-technetium-99m
#16
S I Sazonova, Yu N Il'yushenkova, Yu B Lishmanov, S V Tsibul'nikov, V S Skuridin, E A Nesterov, N V Varlamova, E A Il'ina, V D Filimonov, M V Belyanin, E V Stepanova, S M Minin
Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent (99m)Tc-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue (123)I-PMPDA. (99m)Tc-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart...
April 20, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28428932/a-prime-determinant-in-selecting-dialysis-modality-peritoneal-dialysis-patient-survival
#17
REVIEW
Hyunwook Kim, Dong-Ryeol Ryu
The number of patients with end-stage renal disease (ESRD) has rapidly increased, as has the cost of dialysis. Peritoneal dialysis (PD) is an established treatment for ESRD patients worldwide; it has a variety of advantages, including autonomy and flexibility, as well as economic benefits in many countries compared to hemodialysis (HD). However, the long-term survival rate of PD remains poor. Although direct comparison of survival rate between the dialysis modalities by randomized controlled trials is difficult due to the ethical issues, it has always been a crucial point when deciding which dialysis modality should be recommended to patients...
March 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28428501/job-stress-and-behavioral-characteristics-in-relation-to-coronary-heart-disease-risk-among-japanese-police-officers
#18
Maki Shiozaki, Nobuyuki Miyai, Ikuharu Morioka, Miyoko Utsumi, Sonomi Hattori, Hiroaki Koike, Mikio Arita, Kazuhisa Miyashita
This study examined the association between job-related behavioral characteristics and the risk of coronary heart diseases (CHD) in Japanese male police officers. Compared to office clerks, police officers exhibited greater age-related increases of the prevalence of CHD risk factors, and a clustering number of CHD risk factors was significantly higher in the group of those over 45 years of age. Among the police officers, coronary-prone behavior was more frequent than that seen in office clerks. The police officers with coronary-prone behavior tended to engage in shift work and to work overtime more; yet they were less likely to perceive job stress and to express the relevant physical and psychological symptoms than those without coronary-prone behavior...
April 20, 2017: Industrial Health
https://www.readbyqxmd.com/read/28428195/progression-of-coronary-artery-calcium-and-incident-heart-failure-the-multi-ethnic-study-of-atherosclerosis
#19
Hooman Bakhshi, Bharath Ambale-Venkatesh, Xiaoying Yang, Mohammad R Ostovaneh, Colin O Wu, Matthew Budoff, Hossein Bahrami, Nathan D Wong, David A Bluemke, João A C Lima
BACKGROUND: Although the association between coronary artery calcium (CAC) and future heart failure (HF) has been shown previously, the value of CAC progression in the prediction of HF has not been investigated. In this study, we investigated the association of CAC progression with subclinical left ventricular (LV) dysfunction and incident HF in the Multi-Ethnic Study of Atherosclerosis. METHODS AND RESULTS: The Multi-Ethnic Study of Atherosclerosis is a population-based study consisting of 6814 men and women aged 45 to 84, free of overt cardiovascular disease at enrollment, who were recruited from 4 ethnicities...
April 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28427867/outcomes-from-anomalous-origin-of-the-left-coronary-artery-from-the-pulmonary-artery-repair-long-term-complications-in-relation-to-residual-myocardial-abnormalities
#20
Miki Kanoh, Kei Inai, Tokuko Shinohara, Hirofumi Tomimatsu, Toshio Nakanishi
BACKGROUND: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital coronary artery irregularity. This study aimed to clarify the long-term postoperative outcomes in ALCAPA patients, and to compare the infantile and adult types. METHODS: We retrospectively analyzed the clinical data from 33 patients with ALCAPA who underwent surgical repairs after 1980. The patients were grouped based on whether presentation occurred before (infantile type: n=14) or after (adult type: n=19) 1 year of age...
April 17, 2017: Journal of Cardiology
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