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https://www.readbyqxmd.com/read/29471572/-cardiovascular-medication-in-elderly-patients
#1
Robert H G Schwinger
Elderly people show increased probability to develop atherosclerotic diseases; in consequence heart failure - most often following coronary heart disease - as well as atrial fibrillation is more common. Following guidelines may lead to polypharmacy, i. e. use of more than 5 drugs daily. Thus, drug interactions as well as side effects become more likely; especially in elderly patients reduced kidney function has to be taken into account. Only drugs which have shown to prolong life or to reduce symptoms in controlled clinical trials should be used...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471100/dynamic-fmri-networks-predict-success-in-a-behavioral-weight-loss-program-among-older-adults
#2
Fatemeh Mokhtari, W Jack Rejeski, Yingying Zhu, Guorong Wu, Sean L Simpson, Jonathan H Burdette, Paul J Laurienti
More than one-third of adults in the United States are obese, with a higher prevalence among older adults. Obesity among older adults is a major cause of physical dysfunction, hypertension, diabetes, and coronary heart diseases. Many people who engage in lifestyle weight loss interventions fail to reach targeted goals for weight loss, and most will regain what was lost within 1-2 years following cessation of treatment. This variability in treatment efficacy suggests that there are important phenotypes predictive of success with intentional weight loss that could lead to tailored treatment regimen, an idea that is consistent with the concept of precision-based medicine...
February 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29470800/landiolol-a-review-in-tachyarrhythmias
#3
Yahiya Y Syed
Intravenous landiolol [Rapibloc® (EU)], an ultra short-acting highly cardioselective β1 -blocker, is approved in the EU for the rapid short-term control of tachyarrhythmias in the perioperative and intensive care settings. It has long been used in Japan to treat perioperative tachyarrhythmias. The efficacy of landiolol has been demonstrated in a large number of randomized controlled clinical trials. Landiolol significantly reduced heart rate in patients with postoperative or intraoperative supraventricular tachycardia relative to placebo and in those with atrial fibrillation/flutter and left ventricular dysfunction relative to digoxin...
February 22, 2018: Drugs
https://www.readbyqxmd.com/read/29470136/-15-o-h-2-o-pet-ct-as-a-tool-for-the-quantitative-assessement-of-early-post-radiotherapy-changes-of-heart-perfusion-in-breast-carcinoma-patients
#4
Agnieszka Żyromska, Bogdan Małkowski, Tomasz Wiśniewski, Karolina Majewska, Joanna Reszke, Roman Makarewicz
OBJECTIVE: Studies examining radiation-induced heart toxicity in breast cancer patients are inconclusive. The aim of this study was to prospectively and quantitatively asses myocardial blood flow (MBF) with, for the first time, 15O-H2O PET/CT as a marker of heart damage in irradiated breast cancer patients. METHODS: Fifteen breast cancer patients receiving intact breast or chest wall irradiation were included in the analysis (six with right-sided and nine with left-sided breast cancer)...
February 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29468706/comparative-cardiovascular-safety-of-non-steroidal-anti-inflammatory-drugs-in-patients-with-hypertension-a-population-based-cohort-study
#5
Yaa-Hui Dong, Chia-Hsuin Chang, Li-Chiu Wu, Jing-Shiang Hwang, Sengwee Toh
AIMS: Prior studies have suggested that non-steroidal anti-inflammatory drugs (NSAIDs) may be associated with higher cardiovascular risks. Few were active-comparison studies that directly assessed potential differential cardiovascular risk between NSAID classes or across individual NSAIDs. We compared the risk of major cardiovascular events between cyclooxygenase-2 enzyme (COX-2) selective NSAIDs and nonselective NSAIDs in patients with hypertension. METHODS: We conducted a cohort study of patients with hypertension who initiated COX-2 selective NSAIDs or nonselective NSAIDs in a population-based Taiwanese database...
February 22, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29468590/a-murine-model-of-myocardial-ischemia-reperfusion-injury
#6
Zhaobin Xu, Kevin E McElhanon, Eric X Beck, Noah Weisleder
Ligation of the left anterior descending (LAD) coronary artery in the mouse heart is a widely used model to simulate myocardial infarction and ischemia-reperfusion injury. Here we describe a ligation technique routinely performed in our laboratory to induce myocardial infarction that may be used to study ischemia-reperfusion injury in the myocardium. The methods described enhance location of the LAD coronary artery to allow for accurate ligation, thus increasing reproducibility of infarct size and location.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29467677/ginsenoside-rg1-ameliorates-rat-myocardial-ischemia-reperfusion-injury-by-modulating-energy-metabolism-pathways
#7
Lin Li, Chun-Shui Pan, Li Yan, Yuan-Chen Cui, Yu-Ying Liu, Hong-Na Mu, Ke He, Bai-He Hu, Xin Chang, Kai Sun, Jing-Yu Fan, Li Huang, Jing-Yan Han
As a major ingredient of Radix ginseng , ginsenoside Rg1 (Rg1) has been increasingly recognized to benefit the heart condition, however, the rationale behind the role is not fully understood. In vitro study in H9c2 cardiomyocytes has shown the potential of Rg1 to increase ATP content in the cells. We thus speculated that the protective effect of Rg1 on heart ischemia and reperfusion (I/R) injury implicates energy metabolism regulation. The present study was designed to verify this speculation. Male Sprague-Dawley rats were subjected to 30 min of occlusion of left coronary anterior descending artery followed by reperfusion for 90 min...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467653/the-antioxidant-activity-of-pistachios-reduces-cardiac-tissue-injury-of-acute-ischemia-reperfusion-i-r-in-diabetic-streptozotocin-stz-induced-hyperglycaemic-rats
#8
Rosanna Di Paola, Roberta Fusco, Enrico Gugliandolo, Ramona D'Amico, Michela Campolo, Saverio Latteri, Arianna Carughi, Giuseppina Mandalari, Salvatore Cuzzocrea
Diabetes mellitus is an important risk factor for the development of heart pathology. Myocardial infarction is the cause of death occurring after prolonged ischemia of the coronary arteries. Restoration of blood flow is the first intervention against heart attack, although the process of restoring blood flow to the ischemic myocardium could cause additional injury. This phenomenon, termed myocardial ischemia-reperfusion (MI-R) injury, is characterized by the formation of oxygen radicals. Pistachios have significant glucose- and insulin-lowering effects and can improve the inflammatory contest by downregulating both the expression and the circulating levels of several metabolic risk markers...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29467588/pulmonary-arterial-enlargement-is-associated-with-acute-chest-pain-in-patients-without-obstructive-coronary-artery-disease
#9
Narasa Madam, Wassim Mosleh, Natdanai Punnanithinont, Andres Carmona-Rubio, Zaid H Said, Umesh C Sharma
Background: Pulmonary hypertension (PH) is an underdiagnosed cause for chest pain in patients without significant coronary artery disease (CAD). Studies showed that enlarged pulmonary arterial (PA) and right ventricular chamber sizes correlate with the severity of PH. Therefore, we studied the association between chest pain, right ventricular dimensions (RVDs), and PA size on coronary coronary tomographic angiography (CCTA). Methods: The CCTA of 87 patients presenting with chest pain without evidence of obstructive CAD was examined...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/29467335/apolipoproteins-e-and-ciii-interact-to-regulate-hdl-metabolism-and-coronary-heart-disease-risk
#10
Allyson M Morton, Manja Koch, Carlos O Mendivil, Jeremy D Furtado, Anne Tjønneland, Kim Overvad, Liyun Wang, Majken K Jensen, Frank M Sacks
BACKGROUND: Subspecies of HDL contain apolipoprotein E (apoE) and/or apoCIII. Both proteins have properties that could affect HDL metabolism. The relation between HDL metabolism and risk of coronary heart disease (CHD) is not well understood. METHODS: Eighteen participants were given a bolus infusion of [D3]L-leucine to label endogenous proteins on HDL. HDL was separated into subspecies containing apoE and/or apoCIII and then into 4 sizes. Metabolic rates for apoA-I in HDL subspecies and sizes were determined by interactive modeling...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29467324/angiokine-wisp-1-is-increased-in-myocardial-infarction-and-regulates-cardiac-endothelial-signaling
#11
Lillianne H Wright, Daniel J Herr, Symone S Brown, Harinath Kasiganesan, Donald R Menick
Myocardial infarctions (MIs) cause the loss of myocytes due to lack of sufficient oxygenation and latent revascularization. Although the administration of histone deacetylase (HDAC) inhibitors reduces the size of infarctions and improves cardiac physiology in small-animal models of MI injury, the cellular targets of the HDACs, which the drugs inhibit, are largely unspecified. Here, we show that WNT-inducible secreted protein-1 (Wisp-1), a matricellular protein that promotes angiogenesis in cancers as well as cell survival in isolated cardiac myocytes and neurons, is a target of HDACs...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29467048/pregnancy-associated-spontaneous-coronary-artery-dissection-pascad-an-etiology-for-chest-pain-in-the-young-peripartum-patient
#12
Richard Lee, David Carr
Cardiac emergencies in pregnancy and the postpartum period are rare but often life-threatening. An emergency physician's differential diagnosis for chest pain in the peripartum patient often includes serious etiologies such as pulmonary embolism or myocardial infarction (MI). A lesser-known but important consideration on the differential for MI is that of a spontaneous coronary artery dissection (SCAD). SCAD is defined as an intramural hematoma within the coronary artery that compresses the true lumen. Expansion by increased pressures may lead to subsequent myocardial ischemia and infarction...
February 22, 2018: CJEM
https://www.readbyqxmd.com/read/29466958/case-presentation-implantation-of-cardiac-resynchronization-therapy-pacemaker-via-the-coronary-sinus-in-a-patient-with-triple-valve-replacement
#13
Cheng Zheng, Wei-Qian Lin, Yuan-Zheng Lin, Hao Lian, Zhi-Rui Liu, Jia-Hui Chen, Jia-Feng Lin
BACKGROUND: In patients with triple valve replacement developing third-degree atrioventricular block (AVB), the most appropriate approach for permanent pacemaker implantation remains questionable. CASE PRESENTATION: In this case presentation, we first described the approach of implantation of the cardiac resynchronization therapy pacemaker (CRT-P) via one bipolar pacing lead in middle cardiac vein (MCV) and one quadripolar pacing lead in anterior interventricular vein (AIV) in a patient developing complete AVB, who had been previously diagnosed with rheumatic valvular heart disease with triple valve replaced...
February 21, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29466924/ventriculoatrial-synchrony-induced-heart-failure
#14
Stefan Andric, Dragica Tesic, Dalibor Somer, Ilija Srdanovic, Tatjana Miljkovic, Djordje G Jakovljevic, Lazar Velicki
OBJECTIVE AND IMPORTANCE: Endless loop tachycardia or pacemaker-mediated tachycardia, and atrioventricular desynchronization arrhythmia or repetitive non-reentrant ventriculoatrial synchrony (RNRVAS) are two forms of reverse impulse conduction - ventriculoatrial (VA) synchrony. Although VA synchrony can theoretically cause aggravation of heart failure, clinical cases describing severe consequential heart failure are lacking. CLINICAL PRESENTATION AND INTERVENTION: We describe a case of a 60-year-old patient who underwent primary percutaneous coronary intervention and mitral valve surgery...
February 21, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29466214/-sudden-cardiac-death-in-patients-with-ischemic-heart-disease-from-mechanisms-to-clinical-practice
#15
E Z Golukhova, O I Gromova, N I Bulaeva, L A Bokeria
Ischemic heart disease (IHD) and acute coronary syndrome are the main cause of sudden cardiac death (SCD). Incidence of SCD in patients after myocardial infarction (MI) is 4-6-fold higher than in general population. The review focuses on electrophysiological changes during acute myocardial ischemia and mechanisms of myocardial electromechanical remodeling in remote period after MI. Current data on arrhythmia substrates and triggers are presented. Nowadays, the main guide for implantable cardioverter-defibrillator (ICD) use for primary prevention of SCD is reduced left ventricular ejection fraction...
December 2017: Kardiologiia
https://www.readbyqxmd.com/read/29466206/-carotid-plaque-instability-in-patients-with-acute-coronary-syndrome-as-assessed-by-ultrasound-duplex-scanning
#16
O A Pogorelova, M I Tripoten, D A Guchaeva, R M Shahnovich, M Y Ruda, T V Balakhonova
AIM: to study carotid plaques structure in patients with acute coronary syndrome by ultrasound duplex scanning. MATERIALS AND METHODS: We included in this study143 patients with acute coronary syndrome (ACS) aged 32-83 years and 28 patients with documented coronary heart disease (CHD) aged 46-83 years. Duplex scanning of carotid arteries was carried out with Philips iU22 ultrasound system and L9-3 linear array transducer. Atherosclerotic plaques in CCA, CCA bifurcation, and ICA from right and left side were investigated...
December 2017: Kardiologiia
https://www.readbyqxmd.com/read/29466203/-use-of-highly-concentrated-polyunsaturated-fatty-acids-for-prevention-of-complications-after-myocardial-infarction-cost-utility-analysis
#17
S L Plavinskii, A N Barinova
Use of highly concentrated ethyl esters of polyunsaturated fatty acids after myocardial infarction (MI) and in patients with heart failure was associated with lower mortality. The goal of this analysis was to perform cost-utility analysis of the use of highly concentrated ethyl esters of polyunsaturated fatty acids after MI (with help of a Markov model) and to find whether its use in some group of patients led to decrease in budget costs. As a result, we have shown that use of highly concentrated ethyl esters of polyunsaturated fatty acids after MI leads to increase in quality-adjusted life expectancy on 0...
February 2018: Kardiologiia
https://www.readbyqxmd.com/read/29466167/-lung-hyperinflation-in-chronic-obstructive-pulmonary-disease-and-long-term-outcomes-of-percutaneous-coronary-intervention
#18
V K Zafiraki, E D Kosmachyeva, L V Shulzhenko, D M Ramazanov, A A Omarov, I V Pershukov
OBJECTIVE: to assess the effect of lung hyperinflation (LHI) in patients with chronic obstructive pulmonary disease (COPD) on longterm outcomes of percutaneous coronary intervention (PCI). MATERIALS AND METHODS: Patients with COPD who suffered stable ischemic heart disease and underwent PCI (n=135) were included in a prospective cohort study. LHI was found in 60 patients, while 75 patients had no LHI. Evaluation included comparing the frequency of major adverse cardiac events (MACE) (cardiac death, myocardial infarcпункtion [MI], stroke, repeat revascularization) and Kaplan-Mayer curves between groups of patients with and without LHI...
January 2018: Kardiologiia
https://www.readbyqxmd.com/read/29466116/acute-effects-of-low-level-laser-therapy-on-patients-functional-capacity-in-the-postoperative-period-of-coronary-artery-bypass-graft-surgery-a-randomized-crossover-placebo-controlled-trial
#19
Cinara Stein, Rafael Oliveira Fernandes, Aline Paula Miozzo, Christian Correa Coronel, Bruno Manfredini Baroni, Adriane Belló-Klein, Rodrigo Della Méa Plentz
OBJECTIVE: The aim of this study was to evaluate the acute effects of low-level laser therapy (LLLT) on the functional capacity to exercise tested by incremental shuttle walking test (ISWT) after coronary artery bypass graft (CABG) surgery. METHODS: Fifteen male patients (60 ± 9 years) were crossed over during the experiment, to compare the outcomes after active LLLT and placebo LLLT treatments. LLLT (850 nm, 200 mW, 30 J to each point, resulting in a total of 240 J per quadriceps muscle), using a multidiode cluster (five spots; 6 J/spot) in eight points per leg was performed 3 min before the ISWT...
February 21, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29465628/long-term-clinical-and-computed-tomography-angiographic-follow-up-after-totally-endoscopic-coronary-artery-bypass-grafting
#20
Lukas Stastny, Markus Kofler, Julia Dumfarth, Alim Basaran, Dominik Wiedemann, Thomas Schachner, Gudrun Feuchtner, Johannes Bonatti, Nikolaos Bonaros
OBJECTIVE: Totally endoscopic coronary artery bypass grafting was shown to be feasible and safe, with excellent clinical and angiographic mid-term results. Data on long-term outcome are lacking. Therefore, we aimed to investigate the long-term rate of major adverse cardiac and cerebrovascular events and left internal mammary artery patency rate in patients undergoing arrested heart totally endoscopic coronary artery bypass grafting. METHODS: From 2001 to 2012, a total of 208 arrested heart-totally endoscopic coronary artery bypass grafting patients were prospectively included...
February 21, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
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