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Lifestyle medicine

Nathan S Bryan
PURPOSE OF REVIEW: To reveal the mechanisms of nitric oxide (NO) production in humans and how lifestyle, drug therapy, and hygienic practices can decrease NO production. Furthermore, to show how functional nitric oxide nutrition can overcome these limitations to restore endogenous NO production and combat cardiovascular disease. RECENT FINDINGS: Research over the past decade has revealed that inorganic nitrate and nitrite found naturally in green leafy vegetables and other vegetables such as beets can provide the human body with a source of bioactive nitric oxide...
March 17, 2018: Current Atherosclerosis Reports
Carine Smith
The modern lifestyle is characterised by various factors that cause accelerating ageing by the upregulation of oxidative stress and inflammation-two processes that are inextricably linked in an endless circle of self-propagation. Inflammation in particular is commonly accepted as aetiological factor in many chronic disease states, such as obesity, diabetes and depression. In terms of disease prevention or treatment, interventions aimed at changing dietary and/or exercise habits have had limited success in practise, mostly due to poor long-term compliance...
March 14, 2018: Journal of Physiology and Biochemistry
Sanjay Kalra
Insulin is a life saving medicine. Yet, diabetes care professionals encounter many barriers to its use, especially at the patient level. This is even more true in primary care, where patients tend to resist injectable therapy. This article uses the mnemonic,InfoCRIne, to highlight four important barriers to insulin, and proposes bridges to overcome them. The bridges include information, confidence building, resource husbandry and individualization of strategy. These help overcome the barriers of hearsay, perceived inability to use insulin, perceived lack of resources and intrusion into lifestyle...
March 2018: JPMA. the Journal of the Pakistan Medical Association
Akhilesh S Pathipati, Christine K Cassel
Although they enter school with enthusiasm for a career in medicine, medical students in the United States subsequently report high levels of burnout and disillusionment. As medical school leaders consider how to address this problem, they can look to business schools as one source of inspiration. In this Commentary, the authors argue-based on their collective experience in both medical and business education-that medical schools can draw three lessons from business schools that can help reinvigorate students...
March 13, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Suzanne Phelan, Rena R Wing, Anna Brannen, Angelica McHugh, Todd A Hagobian, Andrew Schaffner, Elissa Jelalian, Chantelle N Hart, Theresa O Scholl, Karen Munoz-Christian, Elaine Yin, Maureen G Phipps, Sarah Keadle, Barbara Abrams
Background: Behavioral lifestyle interventions during pregnancy can prevent excessive gestational weight gain (GWG) in women with normal weight; however, effective interventions to reduce GWG in ethnically diverse women with obesity are lacking. Objective: A randomized controlled trial was conducted to test whether a behavioral lifestyle intervention with partial meal replacement reduces GWG rate in Hispanic and non-Hispanic women with overweight or obesity relative to enhanced usual care...
February 1, 2018: American Journal of Clinical Nutrition
D L Rofey, N E El Nokali, L J Jackson Foster, E Seiler, H L McCauley, E Miller
STUDY OBJECTIVE: To examine the impact of childhood trauma and family history of psychiatric illness on weight loss trajectories of obese, adolescent females with PCOS. DESIGN: Prospective Study SETTING: PCOS and Adolescent Medicine Outpatient Clinics PATIENTS: Participants were, on average, 15.8 years, 80% Caucasian, and had a BMI of 36.8 ± 8.8 kg/m2 . INTERVENTIONS: Healthy Bodies, Healthy Minds is an evidence-based one-on-one intervention consisting of four weekly sessions, four bi-weekly sessions, and three monthly booster sessions...
March 8, 2018: Journal of Pediatric and Adolescent Gynecology
Doris T Zallen
PurposeApolipoprotein-E (APOE) genetic testing to estimate risk for developing late-onset Alzheimer disease is increasingly being offered without prior genetic counseling or preparation. Consumer interest continues to grow, raising the question of how best to conduct such testing.MethodsTwenty-six semistructured interviews were carried out to study the reactions of individuals who had already learned of their higher risk after APOE testing had been done because of a family history of Alzheimer disease, or from genetic tests done for other health-related or general-interest reasons...
March 8, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Hadeel Alkhaneen, Faisal Alhusain, Khalid Alshahri, Nawfal Al Jerian
BACKGROUND: Choosing a medical specialty is a poorly understood process. Although studies conducted around the world have attempted to identify the factors that affect medical students' choice of specialty, data is scarce on the factors that influence the choice of specialty of Saudi Arabian medical students, in particular those planning a career in emergency medicine (EM). In this study, we investigated whether Saudi medical students choosing EM are influenced by different factors to those choosing other specialties...
March 7, 2018: International Journal of Emergency Medicine
Carla Mere Roncal, Mark Bowler, Michael P Gilmore
BACKGROUND: In Amazonia, primates are not only an important food source but they also hold significant cultural and symbolic value for many indigenous groups. We document the relationship between primates and community members of the Maijuna indigenous community of Sucusari in the Peruvian Amazon and describe how ethnoprimatological studies provide a better understanding of the significance of primates in people's lives. Additionally, we explore how ethnoprimatological studies can help inform and enhance primate conservation initiatives...
March 7, 2018: Journal of Ethnobiology and Ethnomedicine
Katie Stoll, Shobana Kubendran, Stephanie A Cohen
Precision medicine aims to approach disease treatment and prevention with consideration of the variability in genes, environment, and lifestyle for each person. This focus on the individual is also key to the practice of genetic counseling, whereby foundational professional values prioritize informed and autonomous patient decisions regarding their genetic health. Genetic counselors are ideally suited to help realize the goals of the precision medicine. However, a limited genetic counseling workforce at a time in which there is a rapidly growing need for services is challenging the balance of supply and demand...
March 7, 2018: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
Otilia Bobiş, Daniel S Dezmirean, Adela Ramona Moise
Diabetes is a metabolic disorder with multifactorial and heterogeneous etiologies. Two types of diabetes are common among humans: type 1 diabetes that occurs when the immune system attacks and destroys insulin and type 2 diabetes, the most common form, that may be caused by several factors, the most important being lifestyle, but also may be determined by different genes. Honey was used in folk medicine for a long time, but the health benefits were explained in the last decades, when the scientific world was concerned in testing and thus explaining the benefits of honey...
2018: Oxidative Medicine and Cellular Longevity
Irina V Chadaeva, Petr M Ponomarenko, Dmitry A Rasskazov, Ekaterina B Sharypova, Elena V Kashina, Dmitry A Zhechev, Irina A Drachkova, Olga V Arkova, Ludmila K Savinkova, Mikhail P Ponomarenko, Nikolay A Kolchanov, Ludmila V Osadchuk, Alexandr V Osadchuk
BACKGROUND: The progress of medicine, science, technology, education, and culture improves, year by year, quality of life and life expectancy of the populace. The modern human has a chance to further improve the quality and duration of his/her life and the lives of his/her loved ones by bringing their lifestyle in line with their sequenced individual genomes. With this in mind, one of genome-based developments at the junction of personalized medicine and bioinformatics will be considered in this work, where we used two Web services: (i) SNP_TATA_Comparator to search for alleles with a single nucleotide polymorphism (SNP) that alters the affinity of TATA-binding protein (TBP) for the TATA boxes of human gene promoters and (ii) PubMed to look for retrospective clinical reviews on changes in physiological indicators of reproductive potential in carriers of these alleles...
February 9, 2018: BMC Genomics
Jingjing Xu, Yanbin Tan, Minming Zhang
Tumor precision medicine is an emerging approach for tumor diagnosis, treatment and prevention, which takes account of individual variability of environment, lifestyle and genetic information. Tumor precision medicine is built up on the medical imaging innovations developed during the past decades, including the new hardware, new imaging agents, standardized protocols, image analysis and multimodal imaging fusion technology. Also the development of automated and reproducible analysis algorithm has extracted large amount of information from image-based features...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Koen Bruynseels, Filippo Santoni de Sio, Jeroen van den Hoven
Personalized medicine uses fine grained information on individual persons, to pinpoint deviations from the normal. 'Digital Twins' in engineering provide a conceptual framework to analyze these emerging data-driven health care practices, as well as their conceptual and ethical implications for therapy, preventative care and human enhancement. Digital Twins stand for a specific engineering paradigm, where individual physical artifacts are paired with digital models that dynamically reflects the status of those artifacts...
2018: Frontiers in Genetics
Delphine Destoumieux-Garzón, Patrick Mavingui, Gilles Boetsch, Jérôme Boissier, Frédéric Darriet, Priscilla Duboz, Clémentine Fritsch, Patrick Giraudoux, Frédérique Le Roux, Serge Morand, Christine Paillard, Dominique Pontier, Cédric Sueur, Yann Voituron
Over the past decade, a significant increase in the circulation of infectious agents was observed. With the spread and emergence of epizootics, zoonoses, and epidemics, the risks of pandemics became more and more critical. Human and animal health has also been threatened by antimicrobial resistance, environmental pollution, and the development of multifactorial and chronic diseases. This highlighted the increasing globalization of health risks and the importance of the human-animal-ecosystem interface in the evolution and emergence of pathogens...
2018: Frontiers in Veterinary Science
Kenji Tsuda, Tetsuya Tanimoto, Saori Sakaue, Tomohiko Sato, Kaduki Kouno, Tamae Hamaki, Kazutaka Hosoda, Mutsuko Ohnishi, Tsunehiko Komatsu, Masahiro Kami, Eiji Kusumi
Hidden barriers to visit a medical facility especially for young busy workers have been neglected in the aging society. The aim of this cross-sectional study is to analyze demographics of patients who had visited the first known convenient clinic located inside a railway station, which is adjusted to the lifestyle of working generations.We analyzed de-identified data of patients who had visited the department of internal medicine of a clinic, which is located inside a railway station building and offers primary care with after-hours accessibility in Tokyo, between August 2013 and June 2016...
January 2018: Medicine (Baltimore)
José I Recio-Rodriguez, Manuel A Gómez-Marcos, Cristina Agudo-Conde, Ignasi Ramirez, Natividad Gonzalez-Viejo, Amparo Gomez-Arranz, Fernando Salcedo-Aguilar, Emiliano Rodriguez-Sanchez, Rosario Alonso-Domínguez, Natalia Sánchez-Aguadero, Jesus Gonzalez-Sanchez, Luis Garcia-Ortiz
INTRODUCTION: Mobile technology, when included within multicomponent interventions, could contribute to more effective weight loss. The objective of this project is to assess the impact of adding the use of the EVIDENT 3 application, designed to promote healthy living habits, to traditional modification strategies employed for weight loss. Other targeted behaviors (walking, caloric-intake, sitting time) and outcomes (quality of life, inflammatory markers, measurements of arterial aging) will also be evaluated...
January 2018: Medicine (Baltimore)
A G Tsai, T Histon, T K Kyle, N Rubenstein, W T Donahoo
Background: Experience suggests that some physicians view obesity as a purely lifestyle condition rather than a chronic metabolic disease. Physicians may not be aware of the role of biological factors in causing weight regain after an initial weight loss. Methods: A questionnaire was administered at continuing medical education conferences, both primary care and obesity-specific. The questionnaire included items about biological and behavioral factors that predispose to weight regain and general items about treatment of obesity...
February 2018: Obesity Science & Practice
Ulrich Hamann, Christine Ankel
LEARNING OBJECTIVES:  After reviewing this article, the participant should be able to: 1. Understand the epidemiology of breast cancer, its incidence and impact. 2. Appreciate the importance of early diagnosis and treatment. 3. Understand the concept of comprehensive breast cancer management and its multidisciplinarity. 4. Be knowledgeable about the entire process required to manage breast cancer, since the early diagnosis until the management of non breast related conditions derived from the treatment...
February 2018: Deutsche Medizinische Wochenschrift
Xingfeng Yu, Janita P C Chau, Lanting Huo
BACKGROUND: Integrative diabetes care, which combines conventional diabetes therapy with traditional Chinese medicine (TCM)-based interventions, has gained popularity worldwide. Numerous TCM-based lifestyle modification approaches have been proposed for individuals with type 2 diabetes (T2DM). OBJECTIVES: To synthesize and present the best available evidence on the effectiveness of TCM-based lifestyle interventions in individuals with T2DM. DESIGN: We undertook a systematic review of randomized controlled trials or controlled clinical trials...
February 19, 2018: International Journal of Nursing Studies
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