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https://www.readbyqxmd.com/read/28333613/collaborative-management-of-neurocognitive-disorders-in-primary-care-explorations-of-an-attempt-at-culture-change
#1
Lewis Mehl-Madrona, Barbara Mainguy
INTRODUCTION: Minor neurocognitive disorder (MiND; previously mild cognitive impairment) is a transitional zone between normal cognitive function and early stages of major neurocognitive disorder (previously called dementia). Of people with MiND, 5% to 10% progress to major neurocognitive disorder. Simple interventions such as memory activities, balance exercises, and anti-inflammatory diets have been shown to improve cognitive ability. Also, education and support in group settings have proved beneficial for patients with MiND...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28331118/reconsideration-of-secondary-risk-management-strategies-in-patients-with-ischemic-heart-disease
#2
Kuninobu Kashiyama, Shinjo Sonoda, Yutaka Otsuji
The main risk factors in ischemic heart diseases, including myocardial infarction, are hypertension, dyslipidemia, diabetes, obesity and smoking. The incidence of ischemic heart disease in Japan has been lower than that in Western countries because of differences in lifestyle and the anatomy of the coronary arteries, but the situation has been changing recently because of the westernization of lifestyle. Cardiovascular diseases have become the second most common cause of death in Japan, and 40% of those deaths are attributed to ischemic heart disease...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28331002/personalized-in-vitro-and-in-vivo-cancer-models-to-guide-precision-medicine
#3
Chantal Pauli, Benjamin D Hopkins, Davide Prandi, Reid Shaw, Tarcisio Fedrizzi, Andrea Sboner, Verena Sailer, Michael Augello, Loredana Puca, Rachele Rosati, Terra J McNary, Yelena Churakova, Cynthia Cheung, Joanna Triscott, David Pisapia, Rema Rao, Juan Miguel Mosquera, Brian Robinson, Bishoy M Faltas, Brooke E Emerling, Vijayakrishna K Gadi, Brady Bernard, Olivier Elemento, Himisha Beltran, Francesca Demichelis, Christopher J Kemp, Carla Grandori, Lewis C Cantley, Mark A Rubin
Precision medicine is an approach that takes into account the influence of individuals' genes, environment, and lifestyle exposures to tailor interventions. Here, we describe the development of a robust precision cancer care platform that integrates whole-exome sequencing with a living biobank that enables high-throughput drug screens on patient-derived tumor organoids. To date, 56 tumor-derived organoid cultures and 19 patient-derived xenograft (PDX) models have been established from the 769 patients enrolled in an Institutional Review Board-approved clinical trial...
March 22, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28326899/prevalence-and-predictors-of-complementary-and-alternative-medicine-non-pharmacological-interventions-use-for-menopausal-symptoms-within-the-uk-collaborative-trial-of-ovarian-cancer-screening
#4
A Gentry-Maharaj, C Karpinskyj, C Glazer, M Burnell, K Bailey, S Apostolidou, A Ryan, A Lanceley, L Fraser, I Jacobs, M S Hunter, U Menon
OBJECTIVES: The negative publicity about menopausal hormone therapy (MHT) has led to increased use of complementary and alternative medicines (CAM) and non-pharmacological interventions (NPI) for menopausal symptom relief. We report on the prevalence and predictors of CAM/NPI among UK postmenopausal women. METHOD: Postmenopausal women aged 50-74 years were invited to participate in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). A total of 202 638 women were recruited and completed a baseline questionnaire...
March 22, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28318814/integrated-yoga-and-naturopathy-module-in-management-of-metabolic-syndrome-a-case-report
#5
Swathi Gowda, Sriloy Mohanty, Apar Saoji, Raghuram Nagarathna
A 50-year-old male participant with sedentary lifestyle, diagnosed with Metabolic Syndrome (MetS) [obesity, Type-2 diabetes mellitus, hypertension] and hypothyroidism since 2013, was administered integrated Yoga and Naturopathy (IYN) for 6 weeks as a tailor made individualized protocol at the residential integrative medical facility in Bangalore between October and November 2015. The results showed reduction in weight (97.9 kg to 74.6 kg), Body Mass Index (BMI) (35.1 kg/m(2) to 27.86 kg/m(2)), total cholesterol (192 mg% to 145 mg%), triglycerides (153 mg% to 90 mg%), Low Density Lipoprotein (LDL) (124 mg% to 81 mg%), High Density Lipoprotein (HDL) (40 mg% to 46 mg%), fasting blood glucose (110 mg/dl to 75 mg/dl), postprandial glucose (267 mg/dl to 100 mg/dl), glycated hemoglobin (HbA1c) (7...
March 16, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28292403/intragastric-balloons-in-clinical-practice
#6
REVIEW
Marianna Papademetriou, Violeta Popov
Cost-effective therapies to address the growing epidemic of obesity are a leading priority in modern medicine. Intragastric balloons (IGBs) are one such option, with increased effectiveness compared with pharmacotherapy and lifestyle and a lower rate of adverse events than bariatric surgery. IGBs are endoscopically placed or swallowed space-occupying devices in the stomach. Three IGB systems were approved in 2015 to 2016 by the Food and Drug Administration for use in the United States, with more devices nearing approval...
April 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28290981/case-report-of-clinical-vignette-osteopetrosis
#7
John B Moore, Thanh D Hoang, Alfred F Shwayhat
INTRODUCTION: Osteopetrosis is a connective tissue disorder resulting from abnormally dense bone predisposing patients to fracture. The clinical pattern of fractures across time and space as well as suggestive radiographic findings usually raises diagnostic suspicion. Multiple genetic mutations resulting in dysfunctional osteoclasts have been implicated in the pathogenesis of osteopetrosis with variable inheritance patterns. In severe cases, usually inherited in an autosomal recessive pattern, the medullary cavity important in the production of normal blood cell progenitors is replaced by defective endochondral bone, leading to pancytopenia and consequential extramedullary hematopoiesis...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28289150/lifestyle-medicine-course-for-family-medicine-residents-preliminary-assessment-of-the-impact-on-knowledge-attitudes-self-efficacy-and-personal-health
#8
Lilach Malatskey, Yael Bar Zeev, Adva Tzuk-Onn, Rani Polak
PURPOSE: The WHO estimates that by 2020 two-thirds of the diseases worldwide will be the result of unhealthy lifestyle habits. Less than half of primary care physician graduates feel prepared to give lifestyle behaviour counselling. Our objective was to evaluate the impact of lifestyle medicine (LM) course on self-reported knowledge, attitudes, self-efficacy and health behaviour of family medicine residents. METHODS: Based on the Israeli syllabus for the study of LM, we delivered five face to face 20 H courses...
March 13, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28282302/exercise-a-vitally-important-prescription
#9
Rachel L Hechanova, Jennifer L Wegler, Christopher P Forest
Sedentary lifestyles and low physical activity have led to rising health concerns and increasing mortality risks. With the growing concern of the inactivity of adult Americans, it is important that physical activity be promoted to prevent disease and reduce health risks. This article reviews the benefits of physical activity and the steps that primary care providers should take to evaluate physical activity as the fifth vital sign in every patient encounter. The 5A's (assess, advise, agree, assist, and arrange) should be applied in order to implement an exercise prescription into the practice of medicine...
March 9, 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28275316/cohort-description-the-danish-study-of-functional-disorders
#10
Thomas Meinertz Dantoft, Jeanette Frost Ebstrup, Allan Linneberg, Sine Skovbjerg, Anja Lykke Madsen, Jesper Mehlsen, Louise Brinth, Lene Falgaard Eplov, Tina Wisbech Carstensen, Andreas Schroder, Per Klausen Fink, Erik Lykke Mortensen, Torben Hansen, Oluf Pedersen, Torben Jørgensen
The Danish study of Functional Disorders (DanFunD) cohort was initiated to outline the epidemiology of functional somatic syndromes (FSS) and is the first larger coordinated epidemiological study focusing exclusively on FSS. FSS are prevalent in all medical settings and can be defined as syndromes that, after appropriate medical assessment, cannot be explained in terms of a conventional medical or surgical disease. FSS are frequent and the clinical importance varies from vague symptoms to extreme disability...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28273476/predicting-polygenic-obesity-using-genetic-information
#11
REVIEW
Ruth J F Loos, A Cecile J W Janssens
Except in rare cases, obesity tends to be a consequence of both an unhealthy lifestyle and a genetic susceptibility to gain weight. With more than 200 common genetic variants identified, there is a growing interest in developing personalized preventive and treatment strategies to predict an individual's obesity risk. We review the literature on the prediction of obesity and show that models based on the established genetic variants have poorer predictive ability than traditional predictors, such as family history of obesity and childhood obesity...
March 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28271925/aarhus-regenerative-orthopaedics-symposium-aros
#12
Casper B Foldager, Michael Bendtsen, Lise C Berg, Jan E Brinchmann, Mats Brittberg, Cody Bunger, Jose Canseco, Li Chen, Bjørn B Christensen, Pauline Colombier, Bent W Deleuran, James Edwards, Brian Elmengaard, Jack Farr, Birgitta Gatenholm, Andreas H Gomoll, James H Hui, Rune B Jakobsen, Natasja L Joergensen, Moustapha Kassem, Thomas Koch, Søren Kold, Michael R Krogsgaard, Henrik Lauridsen, Dang Le, Catherine Le Visage, Martin Lind, Jens V Nygaard, Morten L Olesen, Michael Pedersen, Martin Rathcke, James B Richardson, Sally Roberts, Jan H D Rölfing, Daisuke Sakai, Wei Seong Toh, Jill Urban, Myron Spector
The combination of modern interventional and preventive medicine has led to an epidemic of ageing. While this phenomenon is a positive consequence of an improved lifestyle and achievements in a society, the longer life expectancy is often accompanied by decline in quality of life due to musculoskeletal pain and disability. The Aarhus Regenerative Orthopaedics Symposium (AROS) 2015 was motivated by the need to address regenerative challenges in an ageing population by engaging clinicians, basic scientists, and engineers...
December 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/28271807/2016-the-year-that-was-bone-strength
#13
Kathleen F Janz
Of all the lifestyle strategies for increasing bone strength during the growing years, physical activity is one of the most efficacious. This commentary highlights two exceptional 2016 publications addressing bone strength in children and adolescents with an eye toward reduced fracture risk later in life. The first by Weaver et al. was selected due to its comprehensive approach to understanding bone development. The second by Mitchell et al explores a new field of inquiry, that is, genetic-environment interaction as represented by bone mineral density-lowering alleles and high-impact physical activity...
February 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28269534/addressing-drug-drug-and-drug-food-interactions-through-personalized-empowerment-services-for-healthcare
#14
Marios Spanakis, Emmanouil G Spanakis, Haridimos Kondylakis, Stelios Sfakianakis, Irini Genitsaridi, Vangelis Sakkalis, Manolis Tsiknakis, Kostas Marias
Personalized healthcare systems support the provision of timely and appropriate information regarding healthcare options and treatment alternatives. Especially for patients that receive multi-drug treatments a key issue is the minimization of the risk of adverse effects due to drug-drug interactions (DDIs). DDIs may be the result of doctor prescribed drugs but also due to self-medication of conventional drugs, alternative medicines, food habits, alcohol or smoking. It is therefore crucial for personalized health systems, apart from assisting physicians for optimal prescription practices, to also provide appropriate information for individual users for drug-drug interactions or similar information regarding risks for modulation of the ensuing treatment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268264/opening-plenary-speaker-human-genomics-precision-medicine-and-advancing-human-health
#15
Eric D Green
Starting with the launch of the Human Genome Project in 1990, the past quarter-century has brought spectacular achievements in genomics that dramatically empower the study of human biology and disease. The human genomics enterprise is now in the midst of an important transition, as the growing foundation of genomic knowledge is being used by researchers and clinicians to tackle increasingly complex problems in biomedicine. Of particular prominence is the use of revolutionary new DNA sequencing technologies for generating prodigious amounts of DNA sequence data to elucidate the complexities of genome structure, function, and evolution, as well as to unravel the genomic bases of rare and common diseases...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265035/perspective-on-precision-medicine-in-paediatric-heart-failure
#16
REVIEW
Michael D Fridman, Seema Mital
In 2015, President Obama launched the Precision Medicine Initiative (PMI), which introduced new funding to a method of research with the potential to study rare and complex diseases. Paediatric heart failure, a heterogeneous syndrome affecting approximately 1 in 100000 children, is one such condition in which precision medicine techniques may be applied with great benefit. Current heart failure therapies target downstream effects of heart failure rather than the underlying cause of heart failure. As such, they are often ineffective in paediatric heart failure, which is typically of primary (e...
March 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28260749/body-mass-index-in-adult-asthmatic-patients
#17
S Nasreen, A Nessa, M F Islam, R Sultana, R Akter
Asthma is a chronic inflammatory disorder of the airways, in which many cells and cellular elements play a role. Asthma is one of the most common diseases globally and currently affects 300 million people. Asthma and obesity have an enormous impact on public health. Since the 1990s, various studies have shown a correlation between an increase in body mass index (BMI) and asthma prevalence. This descriptive type of cross sectional study was done to find the levels of BMI in adult asthmatic patients and carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2014 to January 2016...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28257977/review-of-antidiabetic-fruits-vegetables-beverages-oils-and-spices-commonly-consumed-in-the-diet
#18
REVIEW
Maliheh Najari Beidokhti, Anna K Jäger
ETHNOPHARMACOLOGICAL RELEVANCE: Type 2 diabetes is the most common type of diabetes and its prevalence is rapidly increasing throughout the world. Modifications of lifestyle such as suitable diet and exercise programs along with pharmacotherapy and education of patients are beneficial therapies for patients with type 2 diabetes. The ethnopharmacological use of herbal medicines, many of them part of our diet as spices, vegetables and fruits, has been developed for the treatment of diabetes due to inexpensiveness, easy availability and few side effects...
February 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28254105/a-single-case-of-tourette-s-syndrome-treated-with-traditional-chinese-medicine
#19
Min-Hwa Lee
The objective of this case study was to investigate the effectiveness of Chinese medicine in treating Tourette's syndrome. Tourette's syndrome is a childhood- onset disorder that is characterized by sudden, involuntary movements or tics. The participant in this study was a 33-year-old male who had been diagnosed with Tourette's syndrome at the age of 9 years. His major complaints included facial tics, shoulder shrugging, and clearing the throat. Using a combination of acupuncture, herbs, Gua-Sha, and lifestyle changes once a week for 35 treatments, all the symptoms were reduced by 70%, as reported by the patient...
January 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28250793/cytochrome-p450-and-p-glycoprotein-mediated-interactions-involving-african-herbs-indicated-for-common-noncommunicable-diseases
#20
REVIEW
Gregory Ondieki, Makafui Nyagblordzro, Siambi Kikete, Rongjia Liang, Lili Wang, Xin He
Herbal remedies are regularly used to complement conventional therapies in the treatment of various illnesses in Africa. This may be because they are relatively cheap and easily accessible and are believed by many to be safe, cause fewer side effects, and are less likely to cause dependency. On the contrary, many herbs have been shown to alter the pharmacokinetics of coadministered allopathic medicines and can either synergize or antagonize therapeutic effects as well as altering the toxicity profiles of these drugs...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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