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https://www.readbyqxmd.com/read/29764209/next-gen-therapeutics-for-skin-cancer-nutraceuticals
#1
Annapoorna Sreedhar, Jun Li, Yunfeng Zhao
Growing modernization and lifestyle changes with limited physical activity have impacted diet and health, leading to an increased cancer mortality rate worldwide. As a result, there is a greater need than before to develop safe and novel anticancer drugs. Current treatment options such as chemotherapy, radiotherapy and surgery, induce unintended side effects, compromising patient's quality of life, and physical well-being. Therefore, there has been an increased global interest in the use of dietary supplements and traditional herbal medicines for treatment of cancer...
May 15, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29760362/-pharmacology-education-in-nursing-what-should-be-taught-and-how-from-western-to-chinese-medicine
#2
Tomoko Akase
Doctors give prescriptions after considering the medical conditions of patients. Pharmacists check the prescription and give information about the effects of the drugs to the patients, including their side effects. Nurses observe patients to determine the effects and side effects of the administered drugs, and then report these to doctors. Each specialist plays a role, allowing medication to be completed. However, in order to fully attain the effects of a drug, we need to consider the method of its administration...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29755757/need-to-improve-awareness-and-treatment-compliance-in-high-risk-patients-for-diabetic-complications-in-nepal
#3
Raju P Sapkota, Tirthalal Upadhyaya, Govind Gurung, Mike Parker, Rajiv Raman, Shahina Pardhan
Objective/introduction: It is known that knowledge, awareness, and practice influence diabetic control. We compared factors pertaining to healthy lifestyle (exercising, avoiding smoking), self-help (attending appointments, following treatment regimens), and diabetic awareness in high-risk patients for diabetic complications, specifically, those on insulin versus non-insulin treatment, and also those with a longer diabetic duration (≥5 years) versus a shorter duration. Methods: 200 consecutive patients with type 2 diabetes (52...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29755228/effect-of-1-week-yoga-based-residential-program-on-cardiovascular-variables-of-hypertensive-patients-a-comparative-study
#4
Kashinath G Metri, Balaram Pradhan, Amit Singh, H R Nagendra
Introduction: Hypertension (HTN) is an important public health concern and a leading cause of morbidity and mortality worldwide. Yoga is a form of mind-body medicine shown to be effective in controlling blood pressure (BP) and reduces cardiac risk factors in HTN. Integrated approach of Yoga therapy (IAYT) is a residential yoga-based lifestyle intervention proven to be beneficial in several health conditions. Aim: To study the efficacy of 1 week of residential IAYT intervention on cardiovascular parameters in hypertensive patients...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29743938/dysbiotic-drift-and-biopsychosocial-medicine-how-the-microbiome-links-personal-public-and-planetary-health
#5
Susan L Prescott, Ganesa Wegienka, Alan C Logan, David L Katz
The emerging concept of planetary health emphasizes that the health of human civilization is intricately connected to the health of natural systems within the Earth's biosphere; here, we focus on the rapidly progressing microbiome science - the microbiota-mental health research in particular - as a way to illustrate the pathways by which exposure to biodiversity supports health. Microbiome science is illuminating the ways in which stress, socioeconomic disadvantage and social polices interact with lifestyle and behaviour to influence the micro and macro-level biodiversity that otherwise mediates health...
2018: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/29739913/longitudinal-change-of-perceived-salt-intake-and-stroke-risk-in-a-chinese-population
#6
Yun Li, Zhe Huang, Cheng Jin, Aijun Xing, Yesong Liu, Chunmei Huangfu, Alice H Lichtenstein, Katherine L Tucker, Shouling Wu, Xiang Gao
BACKGROUND AND PURPOSE: Data for a relationship between salt intake and stroke have been inconsistent. This inconstancy could be because of the majority of studies evaluated salt intake at a single time point, which may be insufficient to accurately characterize salt intake throughout the observation period. METHODS: Included were 77 605 participants from the Kailuan study. We assessed perceived salt intake via questionnaire in 2006, 2008, and 2010. Salt intake trajectories from 2006 to 2010 were identified using latent mixture models...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29727597/cardiovascular-health-profile-among-qu%C3%A3-bec-male-and-female-police-officers
#7
Philippe Gendron, Claude Lajoie, Louis Laurencelle, François Trudeau
PURPOSE: To document the cardiovascular health profile of Québec police officers (PO). METHODS: Participants answered an online questionnaire evaluating the presence of cardiovascular disease (CVD) risk factors and symptoms. RESULTS: Two thousand, ninety-nine (2,099) male (age: 40.8 ± 9.2 years) and 756 female (age: 37.9 ± 7.9 years) PO participated in this study. The prevalence of obesity (body mass index ≥ 30░kg/m2 ) and diagnosed hypertension was respectively 21...
May 4, 2018: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/29706421/factors-associated-with-uninvestigated-dyspepsia-in-students-at-4-latin-american-schools-of-medicine-a-multicenter-study
#8
L Talledo-Ulfe, O D Buitrago, Y Filorio, F Casanova, L Campos, F Cortés, C R Mejia
INTRODUCTION AND AIMS: Dyspepsia is a multifactorial disease that can involve alcohol, tobacco, or nonsteroidal anti-inflammatory drug use, as well as lifestyle, diet, socioeconomic elements, or psychologic factors. The aim of the present article was to establish the frequency of uninvestigated dyspepsia and determine its associated factors in students at 4 Latin American schools of medicine. MATERIALS AND METHODS: A cross-sectional, analytic study was conducted, in which a survey made up of closed-ended questions was applied at just one point in time...
April 26, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29705970/-i-would-rather-have-it-done-by-a-doctor-laypeople-s-perceptions-of-direct-to-consumer-genetic-testing-dtc-gt-and-its-ethical-implications
#9
Manuel Schaper, Sabine Wöhlke, Silke Schicktanz
Direct-to-consumer genetic testing (DTC GT) has been available for several years now, with varying degrees of regulation across different countries. Despite a restrictive legal framework it is possible for consumers to order genetic tests from companies located in other countries. However, German laypeople's awareness and perceptions of DTC GT services is still unexplored. We conducted seven focus groups (participants n = 43) with German laypeople to explore their perceptions of and attitudes towards commercial genetic testing and its ethical implications...
April 28, 2018: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29700074/emerging-role-of-precision-medicine-in-cardiovascular-disease
#10
REVIEW
Jane A Leopold, Joseph Loscalzo
Precision medicine is an integrative approach to cardiovascular disease prevention and treatment that considers an individual's genetics, lifestyle, and exposures as determinants of their cardiovascular health and disease phenotypes. This focus overcomes the limitations of reductionism in medicine, which presumes that all patients with the same signs of disease share a common pathophenotype and, therefore, should be treated similarly. Precision medicine incorporates standard clinical and health record data with advanced panomics (ie, transcriptomics, epigenomics, proteomics, metabolomics, and microbiomics) for deep phenotyping...
April 27, 2018: Circulation Research
https://www.readbyqxmd.com/read/29695403/the-contribution-of-mmp-7-genotypes-to-colorectal-cancer-susceptibility-in-taiwan
#11
Te-Cheng Yueh, Cheng-Nan Wu, Yi-Wen Hung, Wen-Shin Chang, Chun-Kai Fu, Jen-Sheng Pei, Ming-Hsien Wu, Yi-Liang Lai, Yi-Min Lee, Shiou-Ting Yen, Hsin-Ting Li, Chia-Wen Tsai, DA-Tian Bau
BACKGROUND/AIM: Matrix metalloproteinases (MMPs) play important roles in inflammation and carcinogenesis, but the genotypic role of MMP-7 has never been investigated in colorectal cancer (CRC) among the Taiwanese. Therefore, in this study we aimed to evaluate the contribution of MMP-7 genotypes to the risk of CRC in Taiwan. MATERIALS AND METHODS: In this case-control study, MMP-7 A-181G and C-153T promoter genotypes were determined and their association with CRC risk were investigated among 362 CRC patients and 362 age- and gender-matched healthy controls...
May 2018: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29693607/harnessing-the-power-of-microbiome-assessment-tools-as-part-of-neuroprotective-nutrition-and-lifestyle-medicine-interventions
#12
REVIEW
Miguel Toribio-Mateas
An extensive body of evidence documents the importance of the gut microbiome both in health and in a variety of human diseases. Cell and animal studies describing this relationship abound, whilst clinical studies exploring the associations between changes in gut microbiota and the corresponding metabolites with neurodegeneration in the human brain have only begun to emerge more recently. Further, the findings of such studies are often difficult to translate into simple clinical applications that result in measurable health outcomes...
April 25, 2018: Microorganisms
https://www.readbyqxmd.com/read/29690631/pediatric-integrative-medicine-in-residency-program-relationship-between-lifestyle-behaviors-and-burnout-and-wellbeing-measures-in-first-year-residents
#13
Hilary McClafferty, Audrey J Brooks, Mei-Kuang Chen, Michelle Brenner, Melanie Brown, Anna Esparham, Dana Gerstbacher, Brenda Golianu, John Mark, Joy Weydert, Ann Ming Yeh, Victoria Maizes
It is widely recognized that burnout is prevalent in medical culture and begins early in training. Studies show pediatricians and pediatric trainees experience burnout rates comparable to other specialties. Newly developed Accreditation Council for Graduate Medical Education (ACGME) core competencies in professionalism and personal development recognize the unacceptably high resident burnout rates and present an important opportunity for programs to improve residents experience throughout training. These competencies encourage healthy lifestyle practices and cultivation of self-awareness, self-regulation, empathy, mindfulness, and compassion—a paradigm shift from traditional medical training underpinned by a culture of unrealistic endurance and self-sacrifice...
April 23, 2018: Children
https://www.readbyqxmd.com/read/29686951/lifestyle-practices-and-obesity-in-nepalese-youth-a-cross-sectional-study
#14
Gaurav Nepal, Eans T Tuladhar, Saurav Dahal, Shaik Tanveer Ahamad, Sumikshya Adhikari, Apsara Kandel
Introduction Understanding the lifestyle factors associated with obesity is critical to create a successful intervention that would prevent or reduce the obesity beforehand. However, these factors have not been assessed among Nepalese youths thus far. This study aims to determine the prevalence of obesity and to explore the potential lifestyle risk factors in young university students of Nepal. Methods We included in the study 384 young students aged between 17 and 24 years, pursuing medicine at Tribhuvan University, Institute of Medicine, in this cross-sectional study...
February 20, 2018: Curēus
https://www.readbyqxmd.com/read/29686896/the-association-between-obesity-risk-genes-and-gestational-weight-gain-is-modified-by-dietary-intake-in-african-american-women
#15
Ying Meng, Susan W Groth, Dongmei Li
Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG). The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG. An observational study was conducted with 85 African American pregnant women. Sociodemographic, medical, and lifestyle factors and dietary recalls were collected during pregnancy. Seven obesity-risk genetic variants were genotyped...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29686787/pattern-duration-of-stay-and-outcomes-of-medical-admissions-a-report-from-teaching-community-hospital-in-assir-region-saudi-arabia
#16
Mushabab A Al-Ghamdi, Aref A Bin Abdulhak
Background : Population-based studies are the gold standard to understand the burden of different diseases, plan health care policy and resource allocation, and provide an accurate estimate of disease several disease indices including mortality. However, population-based studies are difficult to undertake in a resource-limited situation where no robust data bases and disease registries are available. Therefore, hospital-based cohorts may be used to inform about the community health. Objectives: We sought to study the pattern of disease causing admission, hospital stay, and outcomes of medical admissions to King Abdullah Hospital in Bisha in order to inform clinicians, public health professionals, and policymakers about the current status of diseases within the community in Bisha...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29685846/standardization-of-laboratory-lipid-profile-assessment-a-call-for-action-with-a-special-focus-on-the-2016-esc-eas-dyslipidemia-guidelines-executive-summary-a-consensus-endorsed-by-the-cardiovascular-risk-and-prevention-group-of-the-portuguese-internal-medicine
#17
Pedro Marques da Silva, João Sequeira Duarte, Pedro von Hafe, Victor Gil, Jorge Nunes de Oliveira, Germano de Sousa
Even with improvements in lifestyle interventions, better control of cardiovascular (CV) risk factors, and improvements in CV outcomes, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in Portugal and Europe. Atherogenic dyslipidemias, particularly hypercholesterolemia, have a crucial causal role in the development of atherosclerotic CVD. The clinical approach to a patient with dyslipidemia requires an accurate diagnosis, based on harmonized and standardized lipid and lipoprotein laboratory assessments...
April 20, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29685153/assessing-self-efficacy-in-type-2-diabetes-management-validation-of-the-italian-version-of-the-diabetes-management-self-efficacy-scale-it-dmses
#18
Rossella Messina, Paola Rucci, Jackie Sturt, Tatiana Mancini, Maria Pia Fantini
BACKGROUND: Being highly self-efficacious is a key factor in successful chronic disease self-management. In the context of measuring self-efficacy in type 2 diabetes management, the Diabetes Management Self-Efficacy Scale (DMSES) is the most widely used scale. The aim of this study was to adapt the English version of the scale to Italian and to evaluate the psychometric properties of the Italian version of DMSES in type 2 diabetes (IT-DMSES). METHODS: We conducted a cross-sectional study of people with type 2 diabetes attending the Endocrine-Metabolic Disease Care Unit of the Internal Medicine Department of San Marino State Hospital between October 2016 and February 2017...
April 23, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29682150/positive-effect-of-acupuncture-and-cupping-in-infertility-treatment
#19
Jun-Xiang Wang, Yang Yang, Yue Song, Liang-Xiao Ma
Background: Infertility is clinically defined as the failure to conceive after 12 months of unprotected sexual intercourse. Organic disorders and lifestyle factors are highly associated with infertility. Generally, acupuncture and its related methods can be applied for treating infertility, according to the theory of Traditional Chinese Medicine. Successful cases of acupuncture-treated infertility without concomitant use of any medication are rare. This article presents a case of an infertile woman having a favorable response to acupuncture treatment...
April 1, 2018: Medical Acupuncture
https://www.readbyqxmd.com/read/29678060/knowledge-driven-interpretation-of-multi-view-data-in-medicine
#20
Parvathy Sudhir Pillai, Lei Feng, Tze-Yun Leong
We propose a new approach to clinical decision support with interpretable recommendations from multi-view data. We introduce a Bayesian network structure learning method to help identify the relevant factors and their relationships. Guided by minimal domain knowledge, this method highlights the significant associations among the demography, medical and family history, lifestyle, and biomarker data to facilitate informed clinical decisions. We demonstrate the effectiveness of the method for detecting mild neurocognitive disorder in the elderly from a real-life dataset in Singapore...
2018: Studies in Health Technology and Informatics
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