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https://www.readbyqxmd.com/read/29327722/healthy-lifestyle-habits-benefit-remission-of-recurrent-aphthous-stomatitis-and-ras-type-ulceration
#1
L Ge
In a clinical setting, it is not practical to separate recurrent aphthous stomatitis (RAS) from RAS-type ulceration in every case, so both conditions have been considered together for the purpose of this article. Due to the lack of consistently effective therapeutic options for RAS, other approaches to treat the disease are considered here, beginning with an analysis of possible aetiological factors. The aetiology of RAS, the most common mucosal disease, remains undefined thus far. A few researchers have proposed psychological disorders as a major factor impacting RAS...
January 12, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29321123/comparative-analysis-of-women-with-notable-subjective-health-indicators-compared-with-participants-in-the-australian-longitudinal-study-on-women-s-health-cross-sectional-survey
#2
Christoph Schnelle, Eunice J Minford, Vanessa McHardy, Jane Keep
BACKGROUND: At least six communities with unusually good health and longevity have been identified, but their lifestyles aren't adopted widely. Informal evidence suggests that women associated with Universal Medicine (UM), a complementary medicine health care organization in Eastern Australia and the United Kingdom with normal lifestyles, also have several unusual health indicators. OBJECTIVE: Our objective was to determine how UM participants compared with women in the Australian population at large on a variety of health indicators...
January 10, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29304189/metabolomics-technology-and-bioinformatics-for-precision-medicine
#3
Rajeev K Azad, Vladimir Shulaev
Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small group or even individual patients based on their genetics, environment and lifestyle. Precision medicine relies heavily on developments in systems biology and omics disciplines, including metabolomics. Combination of metabolomics with sophisticated bioinformatics analysis and mathematical modeling has an extreme power to provide a metabolic snapshot of the patient over the course of disease and treatment or classifying patients into subpopulations and subgroups requiring individual medical treatment...
January 3, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29303838/experiences-related-to-urinary-incontinence-of-stroke-patients-a-qualitative-descriptive-study
#4
Gulcihan Arkan, Ayse Beser, Vesile Ozturk
INTRODUCTION: Poststroke urinary incontinence is a common problem, with a prevalence ranging from 32% to 79%. Urinary incontinence after stroke has negative physiological, psychological, and economic effects, which lead to lifestyle changes for both patients and caregivers. Nurses play an important role in preventing and improving incontinence, understanding the experiences of individuals experiencing incontinence, providing healthcare for them, and implementing behavioral therapy methods...
February 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29302532/does-being-under-treatment-improve-knowledge-attitude-practice-for-hypertension-a-hospital-based-study-from-north-india
#5
Rajiv Kumar Gupta, Shahid Hussain, Zahida Parveen, Sunil Kumar Raina, Bhavna Langer, Rashmi Kumari
Background: Studies suggest that approximately half of patients with raised blood pressure (BP) are undetected, that half of those detected are not treated, and that half of those treated are not controlled, famously described as the "rule of halves." Importantly, the cornerstone of the primary prevention of cardiovascular diseases is early detection and drug treatment (antihypertensive) of patients with high BP. Studies across populations in developed world have shown that awareness and management of high BP levels are far from optimal...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29295846/splenectomy-for-immune-thrombocytopenia-down-but-not-out
#6
Shruti Chaturvedi, Donald M/ Arnold, Keith R McCrae
Splenectomy is an effective therapy for steroid-refractory or dependent immune thrombocytopenia (ITP). With the advent of medical alternatives such as rituximab and thrombopoietin receptor antagonists (TPO-RA), the use of splenectomy has declined and is generally reserved for patients that fail multiple medical therapies. Splenectomy removes the primary site of platelet clearance and autoantibody production, and offers the highest rate of durable response (50-70%) compared to other ITP therapies. However, there are no reliable predictors of splenectomy response, and long-term risks of infection and cardiovascular complications must be considered...
January 2, 2018: Blood
https://www.readbyqxmd.com/read/29287685/medicinal-plants-and-bioactive-natural-compounds-in-the-treatment-of-non-alcoholic-fatty-liver-disease-a-clinical-review
#7
REVIEW
Mohammad Bagherniya, Valerio Nobili, Christopher N Blesso, Amirhossein Sahebkar
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver diseases, and is closely related to metabolic syndrome and its related conditions, diabetes mellitus and dyslipidemia. On the other hand, NAFLD as a multisystem disease increases the risk of several chronic diseases include type 2 diabetes mellitus, cardiovascular disease (CVD), and chronic kidney disease. The main objective was to review the efficacy of bioactive natural compounds assessed by clinical trials. Search literature using four databases (PubMed, EBSCO, Web of Science, and Ovid Medline) to review publications that focused on the impact of bioactive natural compounds in NAFLD treatment...
December 26, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29279429/-developing-exercise-mimicking-drugs-toward-realization-of-preemptive-medicine-for-lifestyle-related-diseases
#8
Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, Takashi Kadowaki
Modern society is characterized by an explosion of lifestyle-related diseases that have, as their basis, obesity due to lack of exercise, which include the metabolic syndrome, diabetes, cardiovascular disease, cancer, and Alzheimer's disease. While exercise is known to be a definitive preventive or therapeutic measure against these diseases, it is clear that contemporary lifestyles tend to make exercise rather difficult to continue. Thus, there are mounting expectations worldwide for exercise-mimicking drugs that activate exercise-mediated signaling pathways...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29248989/stratified-prevention-opportunities-and-limitations-report-on-the-1st-interdisciplinary-cardiovascular-workshop-in-augsburg
#9
Gregor Kirchhof, Josef Franz Lindner, Stephan Achenbach, Klaus Berger, Stefan Blankenberg, Heiner Fangerau, Henner Gimpel, Ulrich M Gassner, Jens Kersten, Dorothea Magnus, Herbert Rebscher, Heribert Schunkert, Stephan Rixen, Paulus Kirchhof
Sufficient exercise and sleep, a balanced diet, moderate alcohol consumption and a good approach to handle stress have been known as lifestyles that protect health and longevity since the Middle Age. This traditional prevention quintet, turned into a sextet by smoking cessation, has been the basis of the "preventive personality" that formed in the twentieth century. Recent analyses of big data sets including genomic and physiological measurements have unleashed novel opportunities to estimate individual health risks with unprecedented accuracy, allowing to target preventive interventions to persons at high risk and at the same time to spare those in whom preventive measures may not be needed or even be harmful...
December 16, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29242176/chinese-cardiovascular-disease-mobile-apps-information-types-information-quality-and-interactive-functions-for-self-management-systematic-review
#10
REVIEW
Bo Xie, Zhaohui Su, Wenhui Zhang, Run Cai
BACKGROUND: China has a large population with cardiovascular disease (CVD) that requires extensive self-management. Mobile health (mHealth) apps may be a useful tool for CVD self-management. Little is currently known about the types and quality of health information provided in Chinese CVD mobile apps and whether app functions are conducive to promoting CVD self-management. OBJECTIVE: We undertook a systematic review to evaluate the types and quality of health information provided in Chinese CVD mobile apps and interactive app functions for promoting CVD self-management...
December 14, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29241506/quality-of-life-and-self-care-in-elderly-patients-with-cardiovascular-diseases-the-effect-of-a-traditional-chinese-medicine-health-educational-intervention
#11
Yi-Qin Sun, An-Li Jiang, San-Mei Chen, Hui Li, Hai-Yan Xing, Fang Wang
AIMS: To explore the effects of a Traditional Chinese Medicine health educational intervention on the quality of life and self-care agency of elderly patients living with chronic cardiovascular disease. BACKGROUND: Cardiovascular disease is a leading cause of morbidity and mortality worldwide. The secondary prevention and treatment for chronic cardiovascular disease emphasize the importance of lifestyle modification. However, behavior-changing is difficult and individual choices are influenced by broader environmental factors...
December 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29235134/sex-hormone-binding-globulin-is-associated-with-androgen-deficiency-features-independently-of-total-testosterone
#12
Giulia Rastrelli, Giovanni Corona, Sarah Cipriani, Edoardo Mannucci, Mario Maggi
OBJECTIVE: It is recognized that total testosterone (TT) does not sufficiently describe androgen status when sex hormone binding globulin (SHBG) is altered. However, in humans, evidence supporting the existence of a hypogonadism due to low T bioactivity is scanty. The aim of the study was to assess whether changes in SHBG levels, independently of TT, are associated with subjective and objective androgen dependent parameters. DESIGN: Cross-sectional observation. PATIENTS: 2622 men (aged 51...
December 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29234426/a-study-of-traditional-chinese-medicine-body-constitution-associated-with-overweight-obesity-and-underweight
#13
Mihui Li, Shuming Mo, Yubao Lv, Zihui Tang, Jingcheng Dong
Objective: The aim of the study was to investigate the associations among the nine types of body constitution in traditional Chinese medicine (TCM) with the outcomes of overweight, obesity, and underweight. Method: Participants aged 30 to 90 years were recruited from communities in Shanghai and assessed using a self-administered questionnaire pertaining to their demographics, lifestyles, and self-reported medical history. The data of 3748 participants with complete information was available for the analysis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29226748/epigenetic-biomarkers-current-strategies-and-future-challenges-for-their-use-in-the-clinical-laboratory
#14
José Luis García-Giménez, Marta Seco-Cervera, Trygve O Tollefsbol, Carlos Romá-Mateo, Lorena Peiró-Chova, Pablo Lapunzina, Federico V Pallardó
Epigenetic modifications and regulators represent potential molecular elements which control relevant physiological and pathological features, thereby contributing to the natural history of human disease. These epigenetic modulators can be employed as disease biomarkers, since they show several advantages and provide information about gene function, thus explaining differences among patient endophenotypes. In addition, epigenetic biomarkers can incorporate information regarding the effects of the environment and lifestyle on health and disease, and monitor the effect of applied therapies...
December 11, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29222619/improvement-in-obstructive-sleep-apnea-after-a-tailored-behavioural-sleep%C3%A2-medicine-intervention-targeting-healthy-eating-and-physical-activity-a-randomised-controlled-trial
#15
Helena Igelström, Pernilla Åsenlöf, Margareta Emtner, Eva Lindberg
PURPOSE: The aim of the present single-centre randomised controlled trial was to assess the effect of a behavioural sleep medicine (BSM) intervention on obstructive sleep apnea (OSA) severity in patients who have been referred for new treatment with continuous positive airway pressure (CPAP). METHODS: After baseline assessment including ventilatory and anthropometric parameters, and physical activity monitoring, 86 patients who were overweight (BMI ≥ 25) and had moderate-severe OSA with apnea-hypopnea index (AHI) ≥ 15 were randomised into a control group (CG; CPAP and advice about weight loss) or an experimental group (ExpG; CPAP and BSM intervention targeting physical activity and eating behaviour)...
December 8, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29218914/advances-in-text-mining-and-visualization-for-precision-medicine
#16
Graciela Gonzalez-Hernandez, Abeed Sarker, Karen O'Connor, Casey Greene, Hongfang Liu
According to the National Institutes of Health (NIH), precision medicine is "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person." Although the text mining community has explored this realm for some years, the official endorsement and funding launched in 2015 with the Precision Medicine Initiative are beginning to bear fruit. This session sought to elicit participation of researchers with strong background in text mining and/or visualization who are actively collaborating with bench scientists and clinicians for the deployment of integrative approaches in precision medicine that could impact scientific discovery and advance the vision of precision medicine as a universal, accessible approach at the point of care...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29214573/post-approval-studies-for-rare-disease-treatments-and-orphan-drugs
#17
William C Maier, Ronald A Christensen, Patricia Anderson
Drug development involves a multi-stage process of drug discovery, animal studies and human clinical trials to assess the safety and efficacy of new medications. Rare disease drug development involves a much smaller number of affected patients, a predominance of pediatric patients and more complicated disease presentation. Post-approval studies are designed to address several limitations associated with the rare disease clinical trials.National and international regulatory agencies in the US and Europe have adopted similar approaches to requirements post-approval data for rare diseases and orphan drug indications...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29214155/a-pilot-randomized-controlled-trial-of-a-technology-based-approach-for-preventing-excess-weight-gain-during-pregnancy-among-women-with-overweight
#18
Ariana M Chao, Sindhu K Srinivas, Stacia K Studt, Lisa K Diewald, David B Sarwer, Kelly C Allison
Objective: Overweight/obesity and excess weight gain during pregnancy are associated with adverse maternal and neonatal outcomes. Few interventions have been effective in limiting gestational weight gain among women with overweight or obesity. This pilot, randomized clinical trial compared treatment as usual (TAU) to a lifestyle modification program delivered via phone for the prevention of excess gestational weight gain in women who had overweight or obesity. Methods: Participants included 41 pregnant women with a body mass index (BMI) ≥ 25 kg/m2 (mean age = 28...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29214130/measuring-adherence-to-a-nutrition-and-exercise-lifestyle-intervention-is-program-adherence-related-to-excessive-gestational-weight-gain
#19
Taniya S Nagpal, Harry Prapavessis, Christina Campbell, Michelle F Mottola
To identify adherence required to achieve target health outcome(s) in nutrition and/or exercise interventions, a measurement tool that tracks objective and self-reported measures of adherence is necessary. The purpose of this study was to design an adherence measurement tool and test it retrospectively on the Nutrition and Exercise Lifestyle Intervention Program (NELIP; Ruchat et al., Medicine and Science in Sports and Exercise, 44(8), 1419-1426, 2012; Mottola et al., Medicine and Science in Sports and Exercise, 42(2), 265-272, 2010), designed to prevent excessive gestational weight gain (EGWG)...
December 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29209906/the-fourth-annual-brds-on-genome-editing-and-silencing-for-precision-medicines
#20
Amit Kumar Chaudhary, Rajan Sharma Bhattarai, Ram I Mahato
Precision medicine is promising for treating human diseases, as it focuses on tailoring drugs to a patient's genes, environment, and lifestyle. The need for personalized medicines has opened the doors for turning nucleic acids into therapeutics. Although gene therapy has the potential to treat and cure genetic and acquired diseases, it needs to overcome certain obstacles before creating the overall prescription drugs. Recent advancement in the life science has helped to understand the effective manipulation and delivery of genome-engineering tools better...
December 5, 2017: Drug Delivery and Translational Research
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