Keke Wei, Huafeng Zhang, Shuaishuai Yang, Yuxiao Cui, Bingxia Zhang, Jincheng Liu, Liang Tang, Yaoyao Tan, Simin Liu, Shiqi Chen, Wu Yuan, Xiao Luo, Chen Chen, Fei Li, Junwei Liu, Jie Chen, Pingwei Xu, Jiadi Lv, Ke Tang, Yi Zhang, Jingwei Ma, Bo Huang
Macrophages in tumors (tumor-associated macrophages, TAMs), a major population within most tumors, play key homeostatic functions by stimulating angiogenesis, enhancing tumor cell growth, and suppressing antitumor immunity. Resetting TAMs by simple, efficacious and safe approach(s) is highly desirable to enhance antitumor immunity and attenuate tumor cell malignancy. Previously, we used tumor cell-derived microparticles to package chemotherapeutic drugs (drug-MPs), which resulted in a significant treatment outcome in human malignant pleural effusions via neutrophil recruitments, implicating that drug-MPs might reset TAMs, considering the inhibitory effects of M2 macrophages on neutrophil recruitment and activation...
January 20, 2023: Signal Transduction and Targeted Therapy