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https://www.readbyqxmd.com/read/28742680/individualized-metabolic-surgery-score-procedure-selection-based-on-diabetes-severity
#1
Ali Aminian, Stacy A Brethauer, Amin Andalib, Amy S Nowacki, Amanda Jimenez, Ricard Corcelles, Zubaidah Nor Hanipah, Suriya Punchai, Deepak L Bhatt, Sangeeta R Kashyap, Bartolome Burguera, Antonio M Lacy, Josep Vidal, Philip R Schauer
OBJECTIVE: To construct and validate a scoring system for evidence-based selection of bariatric and metabolic surgery procedures according to severity of type 2 diabetes (T2DM). BACKGROUND: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) account for >95% of bariatric procedures in United States in patients with T2DM. To date, there is no validated model to guide procedure selection based on long-term glucose control in patients with T2DM. METHODS: A total of 659 patients with T2DM who underwent RYGB and SG at an academic center in the United States and had a minimum 5-year follow-up (2005-2011) were analyzed to generate the model...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742295/common-oral-manifestations-of-select-systemic-diseases-anemia-diabetes-mellitus-and-hiv
#2
Sahar Mirfarsi, Eric T Stoopler, Ho-Hyun (Brian) Sun, Jeffrey A Elo
In this article, we discuss several common abnormal signs and symptoms that may be present in the oral cavity initially with or without any systemic symptoms at a typical dental practice. The purpose of this discussion is to increase clinical awareness for establishing differential diagnoses so that patients may obtain appropriate referrals for appropriate medical treatment.
September 2016: Journal—California Dental Association
https://www.readbyqxmd.com/read/28741264/why-are-diabetes-medications-so-expensive-and-what-can-be-done-to-control-their-cost
#3
REVIEW
Laura N McEwen, Sarah Stark Casagrande, Shihchen Kuo, William H Herman
PURPOSE OF REVIEW: The purposes of this study were to describe how medication prices are established, to explain why antihyperglycemic medications have become so expensive, to show trends in expenditures for antihyperglycemic medications, and to highlight strategies to control expenditures in the USA. RECENT FINDINGS: In the U.S., pharmaceutical manufacturers set the prices for new products. Between 2002 and 2012, expenditures for antihyperglycemic medications increased from $10 billion to $22 billion...
September 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28741257/the-comorbidity-burden-of-patients-with-cluster-headache-a-population-based-study
#4
Shivang Joshi, Paul Rizzoli, Elizabeth Loder
BACKGROUND: Evidence is limited regarding the comorbidity burden of patients with cluster headache (CH). We aimed to characterize comorbid conditions in a cohort of CH patients diagnosed by headache experts, using electronic health record information from the Partners Research Patient Data Registry (RPDR). METHODS: We identified and reviewed the charts of unique patients diagnosed by headache specialists over an 11-year period, and a set of matched controls. Patients were categorized as having Definite, Unconfirmed or no CH...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28740848/patient-characteristics-and-clinical-outcomes-with-low-dose-dabigatran
#5
Ramin Ebrahimi, Janet K Han, Seung H Goe, Michelle Treadwell, Zenaida Feliciano
BACKGROUND/AIMS: Dabigatran, an oral direct thrombin inhibitor, is used in patients with non-valvular atrial fibrillation to reduce thromboembolic events. Whereas the 150 mg dosing regimen has been extensively studied in clinical setting, to date, there is no clinical data on the 75 mg (low dose, "LD") regimen. In this study, we evaluated patient characteristics and clinical outcomes in 49 patients treated with LD dabigatran. METHODS: Electronic medical records were utilized to compare patients from one medical center treated with LD dabigatran to those from the warfarin arm of the RE-LY trial...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28740847/fournier-s-gangrene-lessons-learned-from-multimodal-and-multidisciplinary-management-of-perineal-necrotizing-fasciitis
#6
Orestis Ioannidis, Loukiani Kitsikosta, Dimitris Tatsis, Ioannis Skandalos, Aggeliki Cheva, Aikaterini Gkioti, Ioannis Varnalidis, Savvas Symeonidis, Natalia Antigoni Savvala, Styliani Parpoudi, George K Paraskevas, Manousos George Pramateftakis, Efstathios Kotidis, Ioannis Mantzoros, Konstantinos George Tsalis
BACKGROUND: Fournier's gangrene (FG) is a rapidly evolving necrotizing fasciitis of the perineum and the genital area, the scrotum as it most commonly affects man in the vast majority of cases. It is polymicrobial in origin, due to the synergistic action of anaerobes and aerobes and has a very high mortality. There are many predisposing factors including diabetes mellitus, alcoholism, immunosuppression, renal, and hepatic disease. The prognosis of the disease depends on a lot of factors including but not limited to patient age, disease extent, and comorbidities...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28740662/treatment-for-sternoclavicular-joint-infections-a-multi-institutional-study
#7
Allen Murga, Hannah Copeland, Rachel Hargrove, Jason M Wallen, Salman Zaheer
BACKGROUND: Sternoclavicular joint (SCJ) infections are rare and difficult to manage. Surgery is necessary for treatment. METHODS: A retrospective chart review of the university hospital and Veterans Administration (VA) hospitals of all patients treated for SCJ infections since 2001 was conducted. Fifteen [15] patients were identified and evaluated for the types of infections, risk factors, treatments and survival. RESULTS: All 15 patients were symptomatic including: pain [13], erythema [9], purulent drainage [3], fever greater than 38...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740392/cholecalciferol-improves-glycemic-control-in-type-2-diabetic-patients-a-6-month-prospective-interventional-study
#8
Aml Mohamed Nada, Dalia A Shaheen
BACKGROUND AND PURPOSE: To investigate the effects of vitamin D supplementation on glucose homeostasis and lipid profile in type 2 diabetic patients who have vitamin D deficiency. PATIENTS AND METHODS: One hundred twenty-five type 2 diabetic patients taking oral hypoglycemic agents as mono- or combination therapy were recruited from the diabetes and endocrinology clinic. Subject demographics, duration of diabetes, antidiabetic medication, body mass index (BMI), pulse, and blood pressure (BP) were assessed...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28739632/therapeutic-potential-of-mesenchymal-stem-cells-for-diabetes
#9
Alvaro Moreira, Samuel Kahlenberg, Peter J Hornsby
Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and clinical evidence have substantiated the therapeutic benefit of MSCs in various medical conditions. Currently, MSCs are the most commonly used cell-based therapy in clinical trials because of their regenerative effects, ease of isolation, and low immunogenicity. Experimental and clinical studies have provided promising results using MSCs to treat diabetes...
July 24, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28739455/decision-making-in-critical-limb-ischemia-a-markov-simulation
#10
Aaron J Deutsch, C Charles Jain, Kimberly G Blumenthal, Mark W Dickinson, Anne M Neilan
BACKGROUND: Critical limb ischemia (CLI) is a feared complication of peripheral vascular disease that often requires surgical management and may require amputation of the affected limb. OBJECTIVE: To use a decision model to inform clinical management for a 63-year-old woman with CLI and multiple medical comorbidities, including advanced heart failure and diabetes. METHODS: Markov decision model evaluating four strategies: amputation, surgical bypass, endovascular therapy (e...
July 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28739097/surgery-for-diabetes-clinical-and-mechanistic-aspects
#11
REVIEW
Jordanna Kapeluto, André Tchernof, Laurent Biertho
According to the most recent publication by the Canadian Public Health Agency, obesity affects 25% of adults. In addition, there is a clear association between the recent rise in obesity and the increased prevalence of type 2 diabetes. Medical therapy for obesity has shown limited long-term effectiveness, and surgical treatment is now recognized by medical authorities as part of the armamentarium for the management of type 2 diabetes in severely obese patients. The current indications for obesity surgery and postoperative management are reviewed...
August 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28739093/individual-surgeon-is-an-independent-risk-factor-for-leak-after-double-stapled-colorectal-anastomosis-an-institutional-analysis-of-800-patients
#12
Eduardo García-Granero, Francisco Navarro, Carlos Cerdán Santacruz, Matteo Frasson, Alvaro García-Granero, Franco Marinello, Blas Flor-Lorente, Alejandro Espí
BACKGROUND: Our aim was to assess whether the individual surgeon is an independent risk factor for anastomotic leak in double-stapled colorectal anastomosis after left colon and rectal cancer resection. METHODS: This retrospective analysis of a prospectively collected database consists of a consecutive series of 800 patients who underwent an elective left colon and rectal resection with a colorectal, double-stapled anastomosis between 1993 and 2009 in a specialized colorectal unit of a tertiary hospital with 7 participating surgeons...
July 21, 2017: Surgery
https://www.readbyqxmd.com/read/28738835/incidence-of-and-risk-factors-for-nephrolithiasis-in-patients-with-gout-and-the-general-population-a-cohort-study
#13
A J Landgren, L T H Jacobsson, U Lindström, T Z S Sandström, P Drivelegka, L Björkman, E Fjellstedt, M Dehlin
BACKGROUND: Nephrolithiasis (NL) is known to be associated with gout, although there are few comparative studies on risk and risk factors for NL in gout compared to population cohorts. In this cohort study we investigated: (1) overall incidence of NL in gout (cases) and general population controls; (2) risk and risk factors (common comorbidities and medications) for first-time NL in cases and controls separately. METHODS: Cases (n = 29,968) and age-matched and sex-matched controls (n = 138,678) were identified from the regional healthcare database in western Sweden (VEGA)...
July 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28738823/metformin-suppresses-cancer-initiation-and-progression-in-genetic-mouse-models-of-pancreatic-cancer
#14
Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li, Liankang Sun, Cancan Zhou, Luping Gao, Meng Lei, Bin Yan, Junyu Cao, Wanxing Duan, Qingyong Ma
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer preventive and therapeutic effects of metformin, one of the most widely prescribed medications for type 2 diabetes mellitus. However, its role in pancreatic cancer is not fully elucidated. Herein, we aimed to further study the preventive and therapeutic effects of metformin in genetically engineered mouse models of pancreatic cancer...
July 24, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28738808/carotid-plaque-rather-than-intima-media-thickness-as-a-predictor-of-recurrent-vascular-events-in-patients-with-acute-ischemic-stroke
#15
Hyun Ju Yoon, Kye Hun Kim, Hyukjin Park, Jae Yeong Cho, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
BACKGROUND: To investigate the impacts of carotid plaque and intima-media thickness (IMT) on future vascular events (VEs) in the patients with acute ischemic stroke. METHODS: A total of 479 consecutive Korean patients with acute ischemic stroke were divided into 2 groups according to development of VEs; VE group (65.4 ± 10.9 years) vs no VE group (62.8 ± 13.2 years). VEs were defined as the development of recurrent stroke, coronary events, peripheral arterial disease, and death...
July 24, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28738763/an-evaluation-of-the-clinical-therapeutic-effect-of-lixisenatide-in-type-2-diabetes-patients-a-systematic-literature-review
#16
Arinze Nkemdirim Okere, Janele Montesdeoca, April Glasper, Vakaramoko Diaby
BACKGROUND: With cardiovascular disease accounting for approximately 50% of deaths in patients diagnosed with type 2 diabetes, it is pertinent to initiate anti-diabetic medications with cardiovascular benefits. This systematic clinical review critically examines the clinical therapeutic effect of lixisenatide. METHODS: Data were gathered from articles indexed in PubMed, Google Scholar and Medline from 2010 - 2017, with the following search terms, "lixisenatide" and "GLP-1 receptor agonist...
July 24, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28738686/disparities-in-diabetes-and-hypertension-care-for-individuals-with-serious-mental-illness
#17
Junqing Liu, Jonathan Brown, Suzanne Morton, D E B Potter, Lisa Patton, Milesh Patel, Rita Lewis, Sarah Hudson Scholle
OBJECTIVES: People with serious mental illnesses (SMI), including schizophrenia, bipolar disorder, and major depression, experience early mortality, partly due to comorbid physical health conditions such as diabetes and hypertension. This study examined the quality of diabetes and hypertension care for Medicaid and Medicare enrollees with SMI. STUDY DESIGN: We conducted a retrospective analysis of medical records and claims data from 3 health plans: a Medicaid plan for disabled adults, a Medicaid plan for low-income adults, and a Special Needs Plan for individuals dually enrolled in Medicaid and Medicare...
May 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28738059/predicting-diabetes-mellitus-using-smote-and-ensemble-machine-learning-approach-the-henry-ford-exercise-testing-fit-project
#18
Manal Alghamdi, Mouaz Al-Mallah, Steven Keteyian, Clinton Brawner, Jonathan Ehrman, Sherif Sakr
Machine learning is becoming a popular and important approach in the field of medical research. In this study, we investigate the relative performance of various machine learning methods such as Decision Tree, Naïve Bayes, Logistic Regression, Logistic Model Tree and Random Forests for predicting incident diabetes using medical records of cardiorespiratory fitness. In addition, we apply different techniques to uncover potential predictors of diabetes. This FIT project study used data of 32,555 patients who are free of any known coronary artery disease or heart failure who underwent clinician-referred exercise treadmill stress testing at Henry Ford Health Systems between 1991 and 2009 and had a complete 5-year follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28737991/lowering-cost-share-may-improve-rates-of-home-glucose-monitoring-among-patients-with-diabetes-using-insulin
#19
Yiqiong Xie, Abiy Agiro, Kevin Bowman, Andrea DeVries
BACKGROUND: Not much is known about the extent to which lower cost share for blood glucose strips is associated with persistent filling. OBJECTIVE: To evaluate the relationship between cost sharing for blood glucose testing strips and continued use of testing strips. METHODS: This is a retrospective observational study using medical and pharmacy claims data integrated with laboratory hemoglobin A1c (A1c) values for patients using insulin and blood glucose testing strips...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737758/real-world-experience-with-0-2%C3%A2-%C3%AE-g-day-fluocinolone-acetonide-intravitreal-implant-iluvien-in-the-united-kingdom
#20
C Bailey, U Chakravarthy, A Lotery, G Menon, J Talks
AimsTo compare safety outcomes and visual function data acquired in the real-world setting with FAME study results in eyes treated with 0.2 μg/day fluocinolone acetonide (FAc).MethodsFourteen UK clinical sites contributed to pseudoanonymised data collected using the same electronic medical record system. Data pertaining to eyes treated with FAc implant for diabetic macular oedema (DMO) was extracted. Intraocular pressure (IOP)-related adverse events were defined as use of IOP-lowering medication, any rise in IOP>30 mm Hg, or glaucoma surgery...
July 24, 2017: Eye
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