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https://www.readbyqxmd.com/read/27921426/-gestational-diabetes-mellitus
#1
Hana Krejčí
The present generation of women of childbearing age more frequently suffer from overweight, obesity, initial as well as fully established metabolic syndrome, which together with postponing motherhood until the third decade in life plays an important role in the increasing incidence of gestational diabetes (GDM) that currently affects about 1/5 of pregnant women. However the causal link between diabetes during pregnancy and metabolic diseases in the whole population is mutual. By way of epigenetic changes, maternal diabetes unfavourably programmes metabolism of the offspring, who tend to transfer the disorder to the next generations...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27818228/computerized-insulin-order-sets-and-glycemic-control-in-hospitalized-patients
#2
Bertha Wong, Muhammad M Mamdani, Catherine H Y Yu
OBJECTIVE: To evaluate the impact of computerized provider order entry subcutaneous insulin order sets on inpatient glycemic control and ordering behavior. METHODS: This was an interrupted time series study of non-intensive care patients at an urban teaching hospital. The primary outcome was proportion of capillary blood glucose in optimal range (4.0-10.0 mmol/L [72 -180 mg/dL]) during the six months before and after a change to a computerized provider order entry-integrated insulin order set...
November 3, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27800643/delivery-of-a-growth-restricted-offspring-and-the-association-with-early-onset-impaired-maternal-endothelial-function
#3
Sara L Hillman, Tamara Kubba, David J Williams
BACKGROUND: Women who have had small for gestational age offspring have an increased risk of cardiovascular disease in later life. Endothelial dysfunction is a subclinical sign of early cardiovascular disease. It is unknown whether women who have recently had a pregnancy complicated by fetal growth restriction, in the absence of other maternal and fetal disease, have subclinical endothelial dysfunction. OBJECTIVE: To assess maternal endothelial function six months after a pregnancy complicated by fetal growth restriction...
October 31, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27753964/os-10-03-the-distinctive-effect-of-polysaccharide-peptides-ganoderma-lucidum-as-anti-atherogenesis-in-stable-angina-patients
#4
Nizamuddin Ubaidillah, Djanggan Sargowo, Adriawan Widya, Vitryaturrida Jakfar, Kartika Siwi Proboretno, Mirza Failasufi, Yoga Warahugraha, Fadli Ramadhan, Hesti Wulandari, Dinarsari Hayuning Putri
OBJECTIVE: This study was aimed to evaluate the effects of polysaccharide peptides (PsP) of Ganoderma lucidum as anti inflammation, anti oxidant, anti diabetic and anti lipid in stable angina pectoris patients. DESIGN AND METHOD: This is a quasi clinical trial experimental study on 34 Stable Angina patients in Saiful Anwar General Hospital was determined based on ESC Stable CAD guidelines, with pre-test and post-test design without control. Parameter measured were TNF alfa, IL-6, MDA, SOD, HbA1c, Fasting glucose and Total cholesterol...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27747467/gestational-diabetes-mellitus-its-association-with-obesity-a-prospective-cohort-study
#5
Reihaneh Pirjani, Nooshin Shirzad, Mostafa Qorbani, Mina Phelpheli, Ensieh Nasli-Esfahani, Fatemeh Bandarian, Mahboubeh Hemmatabadi
PURPOSE: The aim of this study was to investigate the association between pre-pregnancy body mass index (BMI) and gestational diabetes mellitus (GDM). METHODS: This prospective study was conducted on 256 pregnant women without diabetes referred for prenatal care in the first trimester of pregnancy to two referral University Hospitals (Shariati and Arash Hospitals) during the years 2012 and 2013. Eligible participants were selected consecutively and were followed until delivery and 6 weeks after that...
October 17, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/27746233/colon-hypersensitivity-to-distension-rather-than-excessive-gas-production-produces-carbohydrate-related-symptoms-in-individuals-with-irritable-bowel-syndrome
#6
Giles Major, Sue Pritchard, Kathryn Murray, Jan Paul Alappadan, Caroline Hoad, Luca Marciani, Penny Gowland, Robin Spiller
BACKGROUND & AIMS: Poorly digested, fermentable carbohydrates may induce symptoms of irritable bowel syndrome (IBS) via unclear mechanisms. We performed a randomized trial with magnetic resonance imaging (MRI) analysis to investigate correlations between symptoms and changes in small- and large-bowel contents after oral challenge. METHODS: We performed a 3-period, cross-over study of 29 adult patients with IBS (based on Rome III criteria, with symptoms of abdominal pain or discomfort for at least 2 days/wk) and reported bloating...
October 14, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27709794/a-randomized-controlled-trial-of-adding-the-dpp-4-inhibitor-sitagliptin-to-ongoing-therapy-with-liraglutide-glp-1-receptor-agonist-increases-in-intact-glp-1-and-gip-but-no-change-in-insulin-glucagon-or-plasma-glucose-following-a-mixed-meal-in-patients-with
#7
Michael A Nauck, Melanie Kahle, Oleg Baranov, Carolyn F Deacon, Jens J Holst
AIMS/HYPOTHESIS: GLP-1 receptor agonists and DPP-4 inhibitors both stimulate GLP-1 receptors. Our objective was to determine, whether the addition of sitagliptin to pre-existing therapy with liraglutide changes glycaemic excursions after a mixed meal. METHODS: 16 subjects with type 2 diabetes treated with metformin and liraglutide (1.2 mg/d for ≥ 2 weeks) were randomized (sealed envelopes), within a cross-over design, to be studied on two occasions, after an overnight fast, with (a) sitagliptin (100 mg p...
October 6, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27643361/os-10-03-the-distinctive-effect-of-polysaccharide-peptides-ganoderma-lucidum-as-anti-atherogenesis-in-stable-angina-patients
#8
Nizamuddin Ubaidillah, Djanggan Sargowo, Adriawan Widya, Vitryaturrida Jakfar, Kartika Siwi Proboretno, Mirza Failasufi, Yoga Warahugraha, Fadli Ramadhan, Hesti Wulandari, Dinarsari Hayuning Putri
OBJECTIVE: This study was aimed to evaluate the effects of polysaccharide peptides (PsP) of Ganoderma lucidum as anti inflammation, anti oxidant, anti diabetic and anti lipid in stable angina pectoris patients. DESIGN AND METHOD: This is a quasi clinical trial experimental study on 34 Stable Angina patients in Saiful Anwar General Hospital was determined based on ESC Stable CAD guidelines, with pre-test and post-test design without control. Parameter measured were TNF alfa, IL-6, MDA, SOD, HbA1c, Fasting glucose and Total cholesterol...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27540877/hypoglycemia-rates-after-restriction-of-high-dose-glargine-in-hospitalized-patients
#9
Sun Y Lee, Gulce Askin, Marie E McDonnell, Lindsay M Arnold, Sara M Alexanian
OBJECTIVE: Hypoglycemia remains one of the main challenges of insulin therapy. To reduce insulin-related hypoglycemia at our institution, we restricted inpatient ordering of high glargine doses (≥0.5 U/kg/day) to endocrine staff in May 2013. This retrospective cohort study assesses its effect on hypoglycemia and glycemic control within 48 hours of admission (ADM). METHODS: We identified 692 adult patients hospitalized at Boston Medical Center who received glargine upon ADM from November 1, 2012 through April 30, 2013 as the pre-intervention group, and 651 adult patients admitted between November 1, 2013 and April 30, 2014 as the postintervention group...
December 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27465014/factors-associated-with-duration-of-inpatient-hospital-stay-for-patients-with-diabetes-mellitus-admitted-to-a-medical-unit-in-a-community-public-hospital
#10
Melissa H Lee, Lillianne Liprino, Jeffrey Brooks, Brenda Cayzer, Fiona Weedon, Kate Bermingham, Alicia J Jenkins, Kevin Rowley, David N O'Neal
The aim was to examine predictors of duration of inpatient hospital stay in people with diabetes mellitus to assist implementation of strategies to reduce hospital stay. This audit prospectively studied patients with diabetes mellitus admitted to a medical unit of an Australian community public hospital. Other outcome measures included glucose treatment optimisation and access to GP and diabetes-specific healthcare professionals. Comparison was made to patients without diabetes mellitus who were admitted concomitantly...
July 28, 2016: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/27324989/brain-derived-neurotrophic-factor-impaired-glucose-metabolism-and-bipolar-disorder-course
#11
Rodrigo B Mansur, Camila M Santos, Lucas B Rizzo, Elson Asevedo, Graccielle R Cunha, Mariane N Noto, Mariana Pedrini, Maiara Zeni-Graiff, Quirino Cordeiro, Maj Vinberg, Flavio Kapczinski, Roger S McIntyre, Elisa Brietzke
OBJECTIVES: The neurotrophin brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker in bipolar disorder (BD). However, current evidence is limited and results have been highly heterogeneous. This study aimed to assess the moderating effect of impaired glucose metabolism (IGM) on plasma levels of BDNF in individuals with BD, and on the relationship between BDNF and variables of illness course. METHODS: We measured and compared the plasma levels of BDNF in individuals with BD (n=57) and healthy controls (n=26)...
June 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27242104/effect-of-diabetes-and-pre-hospital-blood-glucose-level-on-survival-and-recovery-after-out-of-hospital-cardiac-arrest
#12
Ziad Nehme, Resmi Nair, Emily Andrew, Stephen Bernard, Marijana Lijovic, Melanie Villani, Sophia Zoungas, Karen Smith
OBJECTIVE: Diabetes mellitus and blood glucose level (BGL) are emerging as important prognosticators of outcome in critically ill patients. We evaluated the effect of diabetes and pre-hospital BGL on survival to hospital discharge and on 12-month functional recovery after out-of-hospital cardiac arrest (OHCA). DESIGN, SETTING AND PARTICIPANTS: We performed a retrospective analysis of data from a statewide cardiac arrest registry in Victoria, Australia. We included 11 873 adult patients who had had an OHCA of presumed cardiac aetiology between 1 January 2007 and 30 June 2015...
June 2016: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/27221615/impact-of-vitamin-d-deficiency-on-maternal-and-birth-outcomes-in-the-saudi-population-a-cross-sectional-study
#13
Ghadeer K Al-Shaikh, Gehan H Ibrahim, Amel A Fayed, Hazem Al-Mandeel
BACKGROUND: Low serum vitamin D [25(OH)D] has been associated with different health problems worldwide. However, its causal role in several diseases remains unclear. We aimed to correlate vitamin D status with maternal and neonatal outcomes in pregnant females. METHOD: One thousand pregnant women were recruited during early labour from the labour ward of King Khaled University Hospital, Riyadh, Saudi Arabia. Detailed medical data of all participants were collected from their records...
May 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27144930/combination-of-saxagliptin-and-metformin-is-effective-as-initial-therapy-in-new-onset-type-2-diabetes-mellitus-with-severe-hyperglycemia
#14
Ambika Amblee, Daniel Lious, Leon Fogelfeld
CONTEXT: The efficacy/safety of combination oral agents in those with stable newly diagnosed type 2 diabetes (T2DM) with severe hyperglycemia is unknown. OBJECTIVE: The objective of the study was to assess glycemic and β-cell outcomes of two oral regimens. DESIGN: This was an open-label, randomized controlled trial with patients enrolled from 2011 through 2014 and followed up for 12 weeks. SETTING: The study was conducted at a major public hospital in Chicago...
June 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27097509/-continuous-interstitial-subcutaneous-fluid-glucose-isfg-measurement-during-pre-and-intraoperative-periods-for-highly-invasive-surgery
#15
Erika Kusunoki, Kitakata Hidenori, Mayuko Kusano, Rie Teranishi, Hiromi Shibuya, Toshiki Okada
BACKGROUND: Recently ERAS protocol has become common, and patients in our hospital drink preoperative oral fluid with carbohydrate nutrition. The present study evaluates interstitial subcutaneous fluid glucose (ISFG) with CGMS-Gold and ISFG variability is relevant to oral fluid. METHODS: The data was ISFG measurement with CGMS-Gold from 29 patients undergoing esophagus operation, liver resection, and pancreaticoduodenectomy in September 2011 to September 2012. We divided them into two groups...
March 2016: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/27079338/hospital-guidelines-for-diabetes-management-and-the-joint-commission-american-diabetes-association-inpatient-diabetes-certification
#16
Pamela Arnold, Danielle Scheurer, Andrew W Dake, Angela Hedgpeth, Amy Hutto, Caroline Colquitt, Kathie L Hermayer
BACKGROUND: The Joint Commission Advanced Inpatient Diabetes Certification Program is founded on the American Diabetes Association's Clinical Practice Recommendations and is linked to the Joint Commission Standards. Diabetes currently affects 29.1 million people in the USA and another 86 million Americans are estimated to have pre-diabetes. On a daily basis at the Medical University of South Carolina (MUSC) Medical Center, there are approximately 130-150 inpatients with a diagnosis of diabetes...
April 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/26987856/visceral-adiposity-in-the-first-half-of-pregnancy-in-association-with-glucose-lipid-and-insulin-profiles-in-later-pregnancy-a-cohort-study
#17
Andrea Cardoso Pontual, José Natal Figueiroa, Leanne R De Souza, Joel G Ray, João Guilherme Bezerra Alves
Background Obesity is the most common risk factor in pregnancy but few studies have assessed the association of between visceral adiposity (VAT) depth in early to mild pregnancy and insulin resistance (IR), dysglycemia and dyslipidemia in later pregnancy. Objective To assess the association between VAT depth in early to mid pregnancy and IR [homeostatic model assessment of IR (HOMA-IR)], dysglycemia and dyslipidemia in later pregnancy. Methods We completed a prospective cohort study of 344 pregnant women at a single large hospital in Recife, Brazil...
August 2016: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/26975937/effects-of-different-metabolic-states-and-surgical-models-on-glucose-metabolism-and-secretion-of-ileal-l-cell-peptides-protocol-for-a-cross-sectional-study
#18
Alper Celik, John B Dixon, Sjaak Pouwels, Bahri Onur Celik, Fatih Can Karaca, Adarsh Gupta, Sergio Santoro, Surendra Ugale
INTRODUCTION: Obesity and type 2 diabetes mellitus are increasing worldwide, reaching pandemic proportions. The understanding of the role of functional restriction and gut hormones can be a beneficial tool in treating obesity and diabetes. However, the exact hormonal profiles in different metabolic states and surgical models are not known. METHODS AND ANALYSIS: The HIPER-1 Study is a single-centre cross-sectional study in which 240 patients (in different metabolic states and surgical models) will receive an oral mixed-meal tolerance test (OMTT)...
March 14, 2016: BMJ Open
https://www.readbyqxmd.com/read/26968133/ethnicity-and-pre-hospital-care-for-people-with-suspected-cardiac-pain-cross-sectional-study
#19
Zahid Asghar, Viet-Hai Phung, Aloysius Niroshan Siriwardena
OBJECTIVES: Few studies have investigated the quality of pre-hospital care by ethnicity. We aimed to investigate ethnic differences in pre-hospital ambulance care of patients with suspected cardiac pain. METHODS: We conducted a cross-sectional analysis of retrospective electronic clinical data for patients with suspected cardiac pain over one year (August 2011 to July 2012) extracted from a single regional ambulance service. This included patient demographic data, clinical measurements, drugs administered and outcomes, such as transportation to hospital or referral to primary care...
October 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/26786574/diabetes-and-the-association-of-postoperative-hyperglycemia-with-clinical-and-economic-outcomes-in-cardiac-surgery
#20
Giampaolo Greco, Bart S Ferket, David A D'Alessandro, Wei Shi, Keith A Horvath, Alexander Rosen, Stacey Welsh, Emilia Bagiella, Alexis E Neill, Deborah L Williams, Ann Greenberg, Jeffrey N Browndyke, A Marc Gillinov, Mary Lou Mayer, Jessica Keim-Malpass, Lopa S Gupta, Samuel F Hohmann, Annetine C Gelijns, Patrick T O'Gara, Alan J Moskowitz
OBJECTIVE: The management of postoperative hyperglycemia is controversial and generally does not take into account pre-existing diabetes. We analyzed clinical and economic outcomes associated with postoperative hyperglycemia in cardiac surgery patients, stratifying by diabetes status. RESEARCH DESIGN AND METHODS: Multicenter cohort study in 4,316 cardiac surgery patients operated on in 2010. Glucose was measured at 6-h intervals for 48 h postoperatively. Outcomes included cost, hospital length of stay (LOS), cardiac and respiratory complications, major infections, and death...
March 2016: Diabetes Care
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