Read by QxMD icon Read


Shivani M Reddy, Danielle E Rose, James F Burgess, Martin P Charns, Elizabeth M Yano
BACKGROUND: Increasing numbers of women veterans present an organizational challenge to a health care system that historically has served men. Women veterans require comprehensive women's health services traditionally not provided by the Veterans Health Administration. OBJECTIVE: Examine the association of organizational factors and adoption of comprehensive women's health care. STUDY DESIGN: Cross-sectional analysis of the 2007 Veterans Health Administration National Survey of Women Veterans Health Programs and Practices...
October 13, 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
Anne Marie Greenhalgh, Leticia Gonzalez-Blanco, Clemente Garcia-Rizo, Emilio Fernandez-Egea, Brian Miller, Miguel Bernardo Arroyo, Brian Kirkpatrick
BACKGROUND: Some studies have suggested that antipsychotic-naïve patients with nonaffective psychosis (NAP) have glucose intolerance. AIMS: To conduct a systematic review and meta-analysis of fasting glucose (FG), two hour values in the oral glucose tolerance test (2HG), fasting insulin concentration (INS), and insulin resistance (IR). METHOD: We identified possibly relevant studies, then selected studies, following usual guidelines, with two authors reviewing the manuscripts...
October 13, 2016: Schizophrenia Research
Rajesh Patel, Michael J Sweeting, Janet T Powell, Roger M Greenhalgh
BACKGROUND: Short-term survival benefits of endovascular aneurysm repair (EVAR) versus open repair of intact abdominal aortic aneurysms have been shown in randomised trials, but this early survival benefit is lost after a few years. We investigated whether EVAR had a long-term survival benefit compared with open repair. METHODS: We used data from the EVAR randomised controlled trial (EVAR trial 1), which enrolled 1252 patients from 37 centres in the UK between Sept 1, 1999, and Aug 31, 2004...
October 12, 2016: Lancet
Wim Jonckheere, Wannes Dermauw, Vladimir Zhurov, Nicky Wybouw, Jan Van den Bulcke, Carlos A Villarroel, Robert Greenhalgh, Mike Grbić, Rob C Schuurink, Luc Tirry, Geert Baggerman, Richard M Clark, Merijn R Kant, Bartel Vanholme, Gerben Menschaert, Thomas Van Leeuwen
The two-spotted spider mite Tetranychus urticae is an extremely polyphagous crop pest. Alongside an unparalleled detoxification potential for plant secondary metabolites, it has recently been shown that spider mites can attenuate or even suppress plant defenses. Salivary constituents, notably effectors, have been proposed to play an important role in manipulating plant defenses and might determine the outcome of plant-mite interactions. Here, the proteomic composition of saliva from T. urticae lines adapted to various host plants - bean, maize, soy, and tomato - was analyzed using a custom-developed feeding assay coupled with nano-LC tandem mass spectrometry...
October 4, 2016: Molecular & Cellular Proteomics: MCP
Hendrik T Ensing, Ellen S Koster, Timothy A A Sontoredjo, Ad A van Dooren, Marcel L Bouvy
BACKGROUND: Introducing a post-discharge community pharmacist home visit can secure continuity of care and prevent drug-related problems. Currently, this type of pharmaceutical care is not standard practice and implementation is challenging. Mapping the factors influencing the implementation of this new form of care is crucial to ensure successful embedding. OBJECTIVE: To explore which barriers and facilitators influence community pharmacists' adoption of a post-discharge home visit...
August 25, 2016: Research in Social & Administrative Pharmacy: RSAP
Tajia L Green, Stacey M Leventhal, Debora Lim, Kiho Cho, David G Greenhalgh
We previously identified a truncated human glucocorticoid receptor (hGR) isoform of 118 amino acids, hGR-S1(-349A), that despite lacking the major functional domains, was more hyperactive after glucocorticoid treatment than the full-length receptor. Furthermore, its 3' untranslated region (UTR) was required. To dissect the underlying mechanisms for hyperactivity, a series of hGR isoforms with consecutive deletions in the 3' UTR were created to test their transactivation potential using reporter assays. The hGR-S1(-349A) isoform retaining 1303 bp of 3' UTR displayed unusually high activity with or without glucocorticoid stimulation...
September 22, 2016: Shock
Sinead Cook, Bregje de Kok, Maria Lisa Odland
Malawi has one of the highest maternal mortality ratios in the world. Unsafe abortions are an important contributor to Malawi's maternal mortality and morbidity, where abortion is illegal except to save the woman's life. Postabortion care (PAC) aims to reduce adverse consequences of unsafe abortions, in part by treating incomplete abortions. Although global and national PAC policies recommend manual vacuum aspiration (MVA) for treatment of incomplete abortion, usage in Malawi is low and appears to be decreasing, with sharp curettage being used in preference...
September 10, 2016: Health Policy and Planning
Ingrid Parry, Soman Sen, Kelly Sattler-Petrocchi, David Greenhalgh, Tina Palmieri
Cutaneous functional units (CFUs) are fields of skin that functionally contribute to range of motion (ROM) at an associated joint. When replaced with scar tissue, the skin is less extensible and may result in loss of movement at the joint. Consideration of the amount of CFU affected by burn injury is increasingly being used to predict the development of burn scar contracture (BSC) in burn survivors. Previous work established that, in adults, burn rehabilitation time per CFU was the greatest predictor of preventing BSC...
August 18, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
Robert Cartotto, David Greenhalgh
Colloids have been used in varying capacities throughout the history of formula-based burn resuscitation. There is sound experimental evidence that demonstrates colloids' ability to improve intravascular colloid osmotic pressure, expand intravascular volume, reduce resuscitation requirements, and limit edema in unburned tissue following a major burn. Fresh frozen plasma appears to be a useful and effective immediate burn resuscitation fluid but its benefits must be weighed against its costs, and risks of viral transmission and acute lung injury...
October 2016: Critical Care Clinics
Jonathan P Phillips, Saumyabrata Banerjee, Jodie Smith, Mike Fitton, Tristan Davenne, Klaus Ertel, Paul Mason, Thomas Butcher, Mariastefania De Vido, Justin Greenhalgh, Chris Edwards, Cristina Hernandez-Gomez, John Collier
We report on type-I phase-matched second harmonic generation (SHG) in three nonlinear crystals: DKDP (98% deuteration), YCOB (XZ plane), and LBO (XY plane), of 8 J, 10 Hz cryogenic gas cooled Yb:YAG laser operating at 1029.5 nm. DKDP exhibited an efficiency of 45% at a peak fundamental intensity of 0.24 GW/cm<sup>2</sup> for 10 Hz operation at 10 ns. At the same intensity and repetition rate, YCOB and LBO showed 50% and 65% conversion efficiencies, respectively. Significant improvement in conversion efficiency, to a maximum of 82%, was demonstrated in LBO at 0...
August 22, 2016: Optics Express
M Amaku, F Azevedo, M N Burattini, G E Coelho, F A B Coutinho, D Greenhalgh, L F Lopez, R S Motitsuki, A Wilder-Smith, E Massad
The classical Ross-Macdonald model is often utilized to model vector-borne infections; however, this model fails on several fronts. First, using measured (or estimated) parameters, which values are accepted from the literature, the model predicts a much greater number of cases than what is usually observed. Second, the model predicts a single large outbreak that is followed by decades of much smaller outbreaks, which is not consistent with what is observed. Usually towns or cities report a number of recurrences for many years, even when environmental changes cannot explain the disappearance of the infection between the peaks...
August 19, 2016: Epidemiology and Infection
Juliet Hounsome, Amanda Nicholson, Janette Greenhalgh, Tim M Cook, Andrew F Smith, Sharon R Lewis
BACKGROUND: Accidental awareness during general anaesthesia (AAGA) is when a patient unintentionally becomes conscious during a procedure performed with general anaesthesia and subsequently has explicit recall of this event. Incidence estimates for AAGA vary, with the most common estimate being one to two cases per 1000 general anaesthetics. Evidence linking nitrous oxide use and an increased risk of AAGA has come from observational studies data but the literature is contradictory, with some studies finding a protective effect of nitrous oxide...
2016: Cochrane Database of Systematic Reviews
Pavel V Ovseiko, Trisha Greenhalgh, Paula Adam, Jonathan Grant, Saba Hinrichs-Krapels, Kathryn E Graham, Pamela A Valentine, Omar Sued, Omar F Boukhris, Nada M Al Olaqi, Idrees S Al Rahbi, Anne-Maree Dowd, Sara Bice, Tamika L Heiden, Michael D Fischer, Sue Dopson, Robyn Norton, Alexandra Pollitt, Steven Wooding, Gert V Balling, Ulla Jakobsen, Ellen Kuhlmann, Ineke Klinge, Linda H Pololi, Reshma Jagsi, Helen Lawton Smith, Henry Etzkowitz, Mathias W Nielsen, Carme Carrion, Maite Solans-Domènech, Esther Vizcaino, Lin Naing, Quentin H N Cheok, Baerbel Eckelmann, Moses C Simuyemba, Temwa Msiska, Giovanna Declich, Laurel D Edmunds, Vasiliki Kiparoglou, Alison M J Buchan, Catherine Williamson, Graham M Lord, Keith M Channon, Rebecca Surender, Alastair M Buchan
Global investment in biomedical research has grown significantly over the last decades, reaching approximately a quarter of a trillion US dollars in 2010. However, not all of this investment is distributed evenly by gender. It follows, arguably, that scarce research resources may not be optimally invested (by either not supporting the best science or by failing to investigate topics that benefit women and men equitably). Women across the world tend to be significantly underrepresented in research both as researchers and research participants, receive less research funding, and appear less frequently than men as authors on research publications...
2016: Health Research Policy and Systems
Ian Porter, Daniela Gonçalves-Bradley, Ignacio Ricci-Cabello, Chris Gibbons, Jaheeda Gangannagaripalli, Ray Fitzpatrick, Nick Black, Joanne Greenhalgh, Jose M Valderas
Patient-reported outcomes (PROs) are reports of the status of a patient's health condition that come directly from the patient. While PRO measures are a well-developed technology with robust standards in research, their use for informing healthcare decisions is still poorly understood. We review relevant examples of their application in the provision of healthcare and examine the challenges associated with implementing PROs in clinical settings. We evaluate evidence for their use and examine barriers to their uptake, and present an evidence-based framework for the successful implementation of PROs in clinical practice...
August 2016: Journal of Comparative Effectiveness Research
Christopher D Steele, Matthew Greenhalgh, David J Balding
In recent years statistical models for the analysis of complex (low-template and/or mixed) DNA profiles have moved from using only presence/absence information about allelic peaks in an electropherogram, to quantitative use of peak heights. This is challenging because peak heights are very variable and affected by a number of factors. We present a new peak-height model with important novel features, including over- and double-stutter, and a new approach to dropin. Our model is incorporated in open-source R code likeLTD...
July 14, 2016: Statistical Applications in Genetics and Molecular Biology
D V M Bishop, Margaret J Snowling, Paul A Thompson, Trisha Greenhalgh
Delayed or impaired language development is a common developmental concern, yet there is little agreement about the criteria used to identify and classify language impairments in children. Children's language difficulties are at the interface between education, medicine and the allied professions, who may all adopt different approaches to conceptualising them. Our goal in this study was to use an online Delphi technique to see whether it was possible to achieve consensus among professionals on appropriate criteria for identifying children who might benefit from specialist services...
2016: PloS One
Diego-Javier Barrios Antúnez, Mark D Greenhalgh, Charlene Fallan, Alexandra M Z Slawin, Andrew D Smith
The diastereo- and enantioselective synthesis of 2,3-disubstituted trans-2,3-dihydrobenzofuran derivatives (15 examples, up to 96 : 4 dr, 95 : 5 er) via intramolecular Michael addition has been developed using keto-enone substrates and a bifunctional tertiary amine-thiourea catalyst. This methodology was extended to include non-activated ketone pro-nucleophiles for the synthesis of 2,3-disubstituted indane and 3,4-disubstituted tetrahydrofuran derivatives.
July 26, 2016: Organic & Biomolecular Chemistry
Sandra L Taylor, Soman Sen, David G Greenhalgh, MaryBeth Lawless, Terese Curri, Tina L Palmieri
Hospital length of stay (LOS) after burn injury is commonly estimated as 1 day per percent burn, but LOS often exceeds that estimate. The purpose of this study is to develop a novel method for estimating burn hospital LOS at any time during hospitalization. The authors used the American Burn Association National Burn Repository from 2000 to 2009 to directly estimate the median residual LOS (MRLOS) of patients hospitalized for burn injuries and who survived to discharge. The MRLOS is the median of how many more days a burn patient will be hospitalized given that the person has been in hospital for a specified time period...
September 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
Glyn Elwyn, Siestse Wieringa, Trisha Greenhalgh
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
Geoff Wong, Gill Westhorp, Ana Manzano, Joanne Greenhalgh, Justin Jagosh, Trish Greenhalgh
BACKGROUND: Realist evaluation is increasingly used in health services and other fields of research and evaluation. No previous standards exist for reporting realist evaluations. This standard was developed as part of the RAMESES II project. The project's aim is to produce initial reporting standards for realist evaluations. METHODS: We purposively recruited a maximum variety sample of an international group of experts in realist evaluation to our online Delphi panel...
2016: BMC Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"