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https://www.readbyqxmd.com/read/27929198/b%C3%AE-arg448lys-polymorphism-is-associated-with-altered-fibrin-clot-structure-and-fibrinolysis-in-type-2-diabetes
#1
Katie A Greenhalgh, Mark W Strachan, Saad Alzahrani, Paul D Baxter, Kristina F Standeven, Robert F Storey, Robert A S Ariens, Peter J Grant, Jackie F Price, Ramzi A Ajjan
Both type 2 diabetes (T2DM) and Bβ448Lys variant of fibrinogen are associated with dense fibrin clots, impaired fibrinolysis and increased cardiovascular risk. It was our objective to investigate whether BβArg448Lys adds to vascular risk by modulating fibrin network structure and/or fibrinolysis in diabetes. The primary aim was to study effects of BβArg448Lys on fibrin network characteristics in T2DM. Secondary aims investigated interactions between gender and BβArg448Lys substitution in relation to fibrin clot properties and vascular disease...
December 8, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27925823/systematic-reviews-for-policymaking-muddling-through
#2
Trisha Greenhalgh, Kirsti Malterud
No abstract text is available yet for this article.
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27893703/generation-of-genome-scale-metabolic-reconstructions-for-773-members-of-the-human-gut-microbiota
#3
Stefanía Magnúsdóttir, Almut Heinken, Laura Kutt, Dmitry A Ravcheev, Eugen Bauer, Alberto Noronha, Kacy Greenhalgh, Christian Jäger, Joanna Baginska, Paul Wilmes, Ronan M T Fleming, Ines Thiele
Genome-scale metabolic models derived from human gut metagenomic data can be used as a framework to elucidate how microbial communities modulate human metabolism and health. We present AGORA (assembly of gut organisms through reconstruction and analysis), a resource of genome-scale metabolic reconstructions semi-automatically generated for 773 human gut bacteria. Using this resource, we identified a defined growth medium for Bacteroides caccae ATCC 34185. We also showed that interactions among modeled species depend on both the metabolic potential of each species and the nutrients available...
November 28, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27893575/variations-in-burn-excision-and-grafting-a-survey-of-the-american-burn-association
#4
Jacqueline S Israel, David G Greenhalgh, Angela L Gibson
It is unknown whether variations in burn care affect outcomes or affect the success of emerging therapeutics. The purpose of this study was to assess burn surgeons' preferences in excision and grafting to determine if surgical technique affects outcomes. A 71-item survey evaluating skin grafting techniques was emailed to members of the American Burn Association in July and August 2015. The survey was anonymous and voluntary. Relationships between variables were evaluated using Fisher's exact test. A P-value of ≤...
November 15, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27893574/randomized-comparison-of-packed-red-blood-cell-to-fresh-frozen-plasma-transfusion-ratio-of-4-1-vs-1-1-during-acute-massive-burn-excision
#5
Laura A Galganski, David G Greenhalgh, Soman Sen, Tina L Palmieri
This prospective randomized controlled trial compared 1:1 vs 4:1 packed red blood cell with fresh frozen plasma (PRBC/FFP) transfusion strategy on outcomes in children with >20% TBSA burns. Children with >20% TBSA burns were randomized to a 1:1 or 4:1 PRBC/FFP transfusion ratio during burn excision. Parameters measured included demographics, TBSA burn, and Pediatric Risk of Mortality scores. Laboratory values recorded preoperatively, 1 hour, 12 hours, 24 hours, and 1 week postoperatively included prothrombin time, partial thromboplastin time (PTT), international normalized ratio, fibrinogen, protein C, and antithrombin C (AIII)...
November 15, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27869112/a-brief-overview-of-english-primary-care-in-the-last-half-century
#6
Carlota Blanco Rubio, Carmen de Francisco Montero, Francisco Javier González Hernández, Alberto Adrada Bautista, Inmaculada Gabaldón-Rodríguez, Manuel Ortega-Calvo
Key hefts, the hard core of clinical profile, scientific nursing and nowadays of the English School of Primary Care in the last sixty years are revisited. We understand that the most profound intellectual influence has been to Archie Cochrane, among family physicians hard core components we include John Fry (1922-1994), David Metcalfe and Julian Tudor Hart. On the other hand, Lisbeth Hockey (1918-2004), PhD in Nursing, was responsible for several years of Nursing Research Unit at the University of Edinburgh...
November 21, 2016: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27819746/monotherapy-treatment-of-epilepsy-in-pregnancy-congenital-malformation-outcomes-in-the-child
#7
REVIEW
Jennifer Weston, Rebecca Bromley, Cerian F Jackson, Naghme Adab, Jill Clayton-Smith, Janette Greenhalgh, Juliet Hounsome, Andrew J McKay, Catrin Tudur Smith, Anthony G Marson
BACKGROUND: There is evidence that certain antiepileptic drugs (AEDs) are teratogenic and are associated with an increased risk of congenital malformation. The majority of women with epilepsy continue taking AEDs throughout pregnancy; therefore it is important that comprehensive information on the potential risks associated with AED treatment is available. OBJECTIVES: To assess the effects of prenatal exposure to AEDs on the prevalence of congenital malformations in the child...
November 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27816520/inherently-variable-responses-to-glucocorticoid-stress-among-endogenous-retroviruses-isolated-from-23-mouse-strains
#8
Karen Hsu, Young-Kwan Lee, Alex Chew, Sophia Chiu, Debora Lim, David G Greenhalgh, Kiho Cho
Active participation of endogenous retroviruses (ERVs) in disease processes has been exemplified by the finding that the HERV (human ERV)-W envelope protein is involved in the pathogenesis of multiple sclerosis, an autoimmune disease. We also demonstrated that injury-elicited stressors alter the expression of murine ERVs (MuERVs), both murine leukemia virus-type and mouse mammary tumor virus (MMTV)-type (MMTV-MuERV). In this study, to evaluate MMTV-MuERVs' responses to stress (e.g., injury, infection)-elicited systemic glucocorticoid (GC) levels, we examined the GC-stress response of 64 MMTV-MuERV promoters isolated from the genomes of 23 mouse strains...
November 3, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27797949/complex-evolutionary-dynamics-of-massively-expanded-chemosensory-receptor-families-in-an-extreme-generalist-chelicerate-herbivore
#9
Phuong Cao Thi Ngoc, Robert Greenhalgh, Wannes Dermauw, Stephane Rombauts, Sabina Bajda, Vladimir Zhurov, Miodrag Grbić, Yves Van de Peer, Thomas Van Leeuwen, Pierre Rouzé, Richard M Clark
While mechanisms to detoxify plant produced, anti-herbivore compounds have been associated with plant host use by herbivores, less is known about the role of chemosensory perception in their life histories. This is especially true for generalists, including chelicerate herbivores that evolved herbivory independently from the more studied insect lineages. To shed light on chemosensory perception in a generalist herbivore, we characterized the chemosensory receptors (CRs) of the chelicerate two-spotted spider mite, Tetranychus urticae, an extreme generalist...
October 26, 2016: Genome Biology and Evolution
https://www.readbyqxmd.com/read/27789487/blood-pressure-measurement-a-call-to-arms
#10
EDITORIAL
Christine A'Court, James Sheppard, Trisha Greenhalgh
No abstract text is available yet for this article.
November 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27783657/non-market-values-in-a-cost-benefit-world-evidence-from-a-choice-experiment
#11
Florian V Eppink, Matthew Winden, Will C C Wright, Suzie Greenhalgh
In support of natural resource and ecosystem service policy, monetary value estimates are often presented to decision makers along with other types of information. There is some evidence that, presented with such 'mixed' information, people prioritise monetary over non-monetary information. We conduct a discrete choice experiment among New Zealand decision makers in which we manipulate the information presented to participants. We find that providing explicit monetary information strengthens the pursuit of economic benefits as well as the avoidance of environmental damage...
2016: PloS One
https://www.readbyqxmd.com/read/27775859/tissue-selective-expression-of-a-conditionally-active-rock2-estrogen-receptor-fusion-protein
#12
Michael S Samuel, Nicola Rath, Siti F Masre, Sarah T Boyle, David A Greenhalgh, Marina Kochetkova, Sheila Bryson, David Stevenson, Michael F Olson
The serine/threonine kinases ROCK1 and ROCK2 are central mediators of actomyosin contractile force generation that act downstream of the RhoA small GTP-binding protein. As a result, they have key roles in regulating cell morphology and proliferation, and have been implicated in numerous pathological conditions and diseases including hypertension and cancer. Here we describe the generation of a gene-targeted mouse line that enables CRE-inducible expression of a conditionally-active fusion between the ROCK2 kinase domain and the hormone-binding domain of a mutated estrogen receptor (ROCK2:ER)...
October 24, 2016: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/27767013/models-and-applications-for-measuring-the-impact-of-health-research-update-of-a-systematic-review-for-the-health-technology-assessment-programme
#13
James Raftery, Steve Hanney, Trish Greenhalgh, Matthew Glover, Amanda Blatch-Jones
BACKGROUND: This report reviews approaches and tools for measuring the impact of research programmes, building on, and extending, a 2007 review. OBJECTIVES: (1) To identify the range of theoretical models and empirical approaches for measuring the impact of health research programmes; (2) to develop a taxonomy of models and approaches; (3) to summarise the evidence on the application and use of these models; and (4) to evaluate the different options for the Health Technology Assessment (HTA) programme...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27745998/the-role-of-organizational-factors-in-the-provision-of-comprehensive-women-s-health-in-the-veterans-health-administration
#14
Shivani M Reddy, Danielle E Rose, James F Burgess, Martin P Charns, Elizabeth M Yano
BACKGROUND: Increasing numbers of women veterans present an organizational challenge to a health care system that historically has served men. Women veterans require comprehensive women's health services traditionally not provided by the Veterans Health Administration. OBJECTIVE: Examine the association of organizational factors and adoption of comprehensive women's health care. STUDY DESIGN: Cross-sectional analysis of the 2007 Veterans Health Administration National Survey of Women Veterans Health Programs and Practices...
October 13, 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/27743650/meta-analysis-of-glucose-tolerance-insulin-and-insulin-resistance-in-antipsychotic-na%C3%A3-ve-patients-with-nonaffective-psychosis
#15
Anne Marie Greenhalgh, Leticia Gonzalez-Blanco, Clemente Garcia-Rizo, Emilio Fernandez-Egea, Brian Miller, Miguel Bernardo Arroyo, Brian Kirkpatrick
BACKGROUND: Some studies have suggested that antipsychotic-naïve patients with nonaffective psychosis (NAP) have glucose intolerance. AIMS: To conduct a systematic review and meta-analysis of fasting glucose (FG), two hour values in the oral glucose tolerance test (2HG), fasting insulin concentration (INS), and insulin resistance (IR). METHOD: We identified possibly relevant studies, then selected studies, following usual guidelines, with two authors reviewing the manuscripts...
October 13, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27743617/endovascular-versus-open-repair-of-abdominal-aortic-aneurysm-in-15-years-follow-up-of-the-uk-endovascular-aneurysm-repair-trial-1-evar-trial-1-a-randomised-controlled-trial
#16
Rajesh Patel, Michael J Sweeting, Janet T Powell, Roger M Greenhalgh
BACKGROUND: Short-term survival benefits of endovascular aneurysm repair (EVAR) versus open repair of intact abdominal aortic aneurysms have been shown in randomised trials, but this early survival benefit is lost after a few years. We investigated whether EVAR had a long-term survival benefit compared with open repair. METHODS: We used data from the EVAR randomised controlled trial (EVAR trial 1), which enrolled 1252 patients from 37 centres in the UK between Sept 1, 1999, and Aug 31, 2004...
October 12, 2016: Lancet
https://www.readbyqxmd.com/read/27703040/the-salivary-protein-repertoire-of-the-polyphagous-spider-mite-tetranychus-urticae-a-quest-for-effectors
#17
Wim Jonckheere, Wannes Dermauw, Vladimir Zhurov, Nicky Wybouw, Jan Van den Bulcke, Carlos A Villarroel, Robert Greenhalgh, Mike Grbić, Rob C Schuurink, Luc Tirry, Geert Baggerman, Richard M Clark, Merijn R Kant, Bartel Vanholme, Gerben Menschaert, Thomas Van Leeuwen
The two-spotted spider mite Tetranychus urticae is an extremely polyphagous crop pest. Alongside an unparalleled detoxification potential for plant secondary metabolites, it has recently been shown that spider mites can attenuate or even suppress plant defenses. Salivary constituents, notably effectors, have been proposed to play an important role in manipulating plant defenses and might determine the outcome of plant-mite interactions. Here, the proteomic composition of saliva from T. urticae lines adapted to various host plants-bean, maize, soy, and tomato-was analyzed using a custom-developed feeding assay coupled with nano-LC tandem mass spectrometry...
December 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27663391/pharmacists-barriers-and-facilitators-on-implementing-a-post-discharge-home-visit
#18
Hendrik T Ensing, Ellen S Koster, Timothy A A Sontoredjo, Ad A van Dooren, Marcel L Bouvy
BACKGROUND: Introducing a post-discharge community pharmacist home visit can secure continuity of care and prevent drug-related problems. Currently, this type of pharmaceutical care is not standard practice and implementation is challenging. Mapping the factors influencing the implementation of this new form of care is crucial to ensure successful embedding. OBJECTIVE: To explore which barriers and facilitators influence community pharmacists' adoption of a post-discharge home visit...
August 25, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27660999/a-tri-nucleotide-pattern-in-a-3-utr-segment-affects-the-activity-of-a-human-glucocorticoid-receptor-isoform
#19
Tajia L Green, Stacey M Leventhal, Debora Lim, Kiho Cho, David G Greenhalgh
We previously identified a truncated human glucocorticoid receptor (hGR) isoform of 118 amino acids, hGR-S1(-349A), that despite lacking the major functional domains, was more hyperactive after glucocorticoid treatment than the full-length receptor. Furthermore, its 3' untranslated region (UTR) was required. To dissect the underlying mechanisms for hyperactivity, a series of hGR isoforms with consecutive deletions in the 3' UTR were created to test their transactivation potential using reporter assays. The hGR-S1(-349A) isoform retaining 1303 bp of 3' UTR displayed unusually high activity with or without glucocorticoid stimulation...
September 22, 2016: Shock
https://www.readbyqxmd.com/read/27616307/-it-s-a-very-complicated-issue-here-understanding-the-limited-and-declining-use-of-manual-vacuum-aspiration-for-postabortion-care-in-malawi-a-qualitative-study
#20
Sinead Cook, Bregje de Kok, Maria Lisa Odland
Malawi has one of the highest maternal mortality ratios in the world. Unsafe abortions are an important contributor to Malawi's maternal mortality and morbidity, where abortion is illegal except to save the woman's life. Postabortion care (PAC) aims to reduce adverse consequences of unsafe abortions, in part by treating incomplete abortions. Although global and national PAC policies recommend manual vacuum aspiration (MVA) for treatment of incomplete abortion, usage in Malawi is low and appears to be decreasing, with sharp curettage being used in preference...
September 10, 2016: Health Policy and Planning
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