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anticoagulants news

Melina Verso, Laura Franco, Michela Giustozzi, Cecilia Becattini, Giancarlo Agnelli
About 15% of patients with cancer experience one or more episodes of venous thromboembolism (VTE) during the course of their disease. In patients with cancer, VTE has a substantial impact on the quality of life and care. Current guidelines recommend low-molecular-weight heparin (LMWH) as first choice therapy for long-term anticoagulation in cancer patients with VTE. However, there are several practical issues concerning the long-term use of these anticoagulants. In the last years, several direct oral anticoagulants (DOACs) have emerged as alternatives to heparins and vitamin K antagonists for the treatment of VTE, but data regarding both efficacy and safety of DOACs in the subgroup of patients with cancer treatments were limited...
April 2018: Thrombosis Research
S Galliazzo, M P Donadini, W Ageno
The direct oral anticoagulants (DOACs) are recommended as the first-choice anticoagulants for both stroke prevention in patients with non-valvular atrial fibrillation and the treatment and secondary prevention of venous thromboembolism. DOACs cause bleeding, albeit less than warfarin. Most bleeding complications can be controlled by general reversal strategies and supportive care. However, in case of life-threatening bleeding, or when urgent invasive procedures are needed, a more rapid and thorough reversal may be required...
April 2018: Thrombosis Research
Gabriela Cesarman-Maus, Guillermo J Ruiz-Argüelles
BACKGROUND: The 10th edition of the CHEST Guideline and Expert Panel Report for the treatment of venous thromboembolism (VTE) was recently updated with recommendations on both the choice of anticoagulants and the duration of treatment in diverse clinical scenarios. METHOD: In this paper, we focus on news in the use of direct oral anticoagulants (DOACS), a group of synthetic low molecular weight drugs capable of directly and specifically inhibiting either activated factor X or both free and fibrin- bound thrombin...
2017: Current Drug Metabolism
Duowu Zou, Khean-Lee Goh
Both proton pump inhibitors (PPIs) and clopidogrel are widely prescribed in the Asia-Pacific population. PPIs are the mainstay therapeutic agents for prophylaxis against aspirin gastropathy and for acid-related disorders including gastroesophageal reflux disease. They are also co-prescribed with oral anticoagulant agents and with dual-antiplatelet therapy for the treatment and prevention of gastrointestinal bleeding. Clopidogrel belongs to the drug class of thienopyridines and is currently the most widely prescribed oral anticoagulant agent either alone or in combination with aspirin...
June 2017: Journal of Gastroenterology and Hepatology
Li-Wei Lo, Tze-Fan Chao, Shih-Ann Chen
No abstract text is available yet for this article.
August 2016: Journal of Cardiovascular Electrophysiology
Françoise Boehlen, Marc Blondon, Pierre Fontana
This update describes contemporary studies of clinical relevance in angiology and hemostasis. We discuss newer developments for the treatment of haemophilia, with a focus on drugs with longer-half lives. Direct anticoagulants (DOAC: rivaroxaban, apixaban, edoxaban and dabigatran) and their approved prescription in Switzerland are summarized, with a description of antidotes that will be available in the near future. We will present new data on the utility of cancer screening at the diagnosis of idiopathic venous thromboembolism (VTE) and on the evaluation of DOAC in patients with cancer-related VTE...
January 13, 2016: Revue Médicale Suisse
E Laffitte
This article focuses on current trends in various autoimmune diseases of interest for the dermatologist. In the antiphospholipid syndrome, many news: better characterization of the severe disease, involvement of the mTOR pathway in the vasculopathy-induced renal disease, and diversification of the therapeutic approaches: use of mTOR inhibitors and several biologics, new various antiplatelet and anticoagulants. In dermatomyositis, new autoantibodies are better characterized with a good correlation with clinical disease; the results of a large study on genetic predisposition to the disease are available...
December 2014: Annales de Dermatologie et de Vénéréologie
J I Cuende, C Lahoz, P Armario, J García-Alegría, J Ena, G García de Casasola, J M Mostaza
During 2013 and the first months of 2014, numerous studies have been published in the cardiovascular field. New guidelines have appeared for managing arterial hypertension and reducing cardiovascular risk by lowering cholesterol levels. New data have emerged on the considerable lipid-lowering efficacy of monoclonal antibodies against PCSK-9, in contrast, however, to the clinical trials directed towards raising HDL-cholesterol with nicotinic acid, which have not shown a reduction in the rate of cardiovascular complications...
January 2015: Revista Clínica Española
Dronacharya Lamichhane
Stroke is becoming a major cause of morbidity and mortality in the developing world while the trend is actually downward in the developed nations. This is mostly because of the better recognition, treatment options and secondary prevention in addition to changes in lifestyles. There have been significant developments in the secondary prevention of ischaemic stroke in the last decade alone. Newer medications like direct thrombin inhibitors and factor Xa inhibitors have come into common practice. These medications are either equally effective or even better than age-old warfarin...
July 2014: JPMA. the Journal of the Pakistan Medical Association
Marianna Spatola, Andrea O Rossetti, Patrick Michel, Thierry Kuntzer, David Benninger, Bernard Nater, Jean-François Démonet, Myriam Schluep, Renaud A Du Pasquier, François Vingerhoets
In 2013, perampanel is approved as an add-on treatment for generalised and focal seizures in pharmaco-resistant epilepsy. New anticoagulants are superior to antivitamin K in stroke secondary prevention in case of atrial fibrillation. DBS remains a valid therapeutic option for advanced Parkinson's disease. Intranasal ketamine seems to reduce the intensity of severe migraine aura. High concentrations of topic capsaicin improve post-herpetic neuralgia. In Alzheimer's disease, statins might deteriorate cognitive functions...
January 15, 2014: Revue Médicale Suisse
Kartik Sunagar, Eivind A B Undheim, Holger Scheib, Eric C K Gren, Chip Cochran, Carl E Person, Ivan Koludarov, Wayne Kelln, William K Hayes, Glenn F King, Agosthino Antunes, Bryan Grieg Fry
UNLABELLED: Due to the extreme variation of venom, which consequently results in drastically variable degrees of neutralization by CroFab antivenom, the management and treatment of envenoming by Crotalus oreganus helleri (the Southern Pacific Rattlesnake), one of the most medically significant snake species in all of North America, has been a clinician's nightmare. This snake has also been the subject of sensational news stories regarding supposed rapid (within the last few decades) evolution of its venom...
March 17, 2014: Journal of Proteomics
Roberto Ervo
The technique of single needle dialysis (SN) was invented in the 1960s and enjoyed great success during the 1970s and '80s in northern Europe, particularly in Belgium. In recent years, the double needle mode has awakened new interest in this technique, as it may represent a good alternative to the use of a central venous catheter at the beginning of dialysis, while waiting for the growth of the arteriovenous fistula. For today's dialysis patients, mostly elderly with ever greater numbers of co-morbid conditions, in particular vascular disease, treatments have become ever more flexible and individually tailored...
May 2013: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
José Carlos del Castillo Rodríguez, Ignacio Fernández Lozano
Atrial fibrillation (AF), is the most prevalent sustained arrhythmia in general population, affecting up to 10% in patients of advanced age. AF doubles overall mortality and increases up to 5-6 times the risk of stroke, which have the characteristic of being particularly harmful. The basis of treatment on AF are the rhythm or rate control and the prevention of thromboembolism. For the latter purpose the treatments that have been most effective are oral anticoagulants. For decades and until just a few years ago, the only oral drugs available for this purpose have been the anti-vitamin K, mainly represented in our country by acenocoumarol and lesser extent by warfarin...
April 2013: Atencion Primaria
J I Arcelus, F García-Bragado, D Jiménez, F S Lozano Sánchez, R Lecumberri, P Román Sánchez et al.
This paper brings together the latest developments that have occurred in different aspects of venous thromboembolism (VTE): VTE prophylaxis in high-risk orthopedic surgery and acutely ill hospitalized medical patients; therapeutic advances in pulmonary embolism and superficial vein thrombosis and VTE future prospects. It summarizes the reviews that five speakers made in-depth for the Second Day in New Anticoagulant Treatment, held in Madrid on November 18, 2011, organized by the Foundation for the Study of Thromboembolic Disease in Spain and endorsed by the Spanish Society of Internal Medicine, Spanish Society of Pneumology and Thoracic Surgery, Spanish Society of Cardiology, Spanish Society of Thrombosis and Haemostasis and the Spanish Society of Angiology and Vascular Surgery...
September 2012: Revista Clínica Española
(no author information available yet)
No abstract text is available yet for this article.
November 2011: Cardiovascular Journal of Africa
Céline Chauleur, Jean-Christophe Gris, Pierre Seffert, Patrick Mismetti
OBJECTIVES: State of the art of antithrombotics and their use recommendations during pregnancy. METHODS: A review RESULTS: Aspirin and heparins remain the safest molecules during pregnancy, and oral anticoagulants are still used for mechanical valves. Heparinoids are the methods of choice in case of heparin-induced thrombopenia but other molecules could find their place: fondaparinux at first and possibly the direct thrombin inhibitors. Thrombolysis may be used in case of life-threatening incident...
September 2011: Thérapie
X Rabasseda
As jazz and indeed most music has rhythm at its very core, so does life with the heart steadily pumping blood to the body. But as in jazz rhythm, irregular rhythm is paired with changes in pitch and velocity making melody and harmony, so it is to a large extent in heart disease, with irregular rhythm, irregular pumping effectiveness, arterial stiffness and so many diverse alterations completely changing the melody of life. Pairing music with the heart makes New Orleans a very reasonable place for the American College of Cardiology's scientific session to be held...
May 2011: Drugs of Today
(no author information available yet)
No abstract text is available yet for this article.
April 2011: Johns Hopkins Medical Letter Health After 50
Mihai Bîscă
No abstract text is available yet for this article.
2010: Oftalmologia
João Morais
Antithrombotic therapy is the cornerstone of management of patients with acute coronary syndromes. Its role has become increasingly important with the widespread use of percutaneous revascularization, particularly after stent implantation. In this context, use of dual antiplatelet therapy is mandatory, combining aspirin with thienopyridines, mostly clopidogrel. As well as antiplatelets, anticoagulants are also required in patients with acute myocardial infarction up to the time of percutaneous intervention and stent implantation...
May 2010: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
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