Chen Jian-Min, Wang Zhi-Yuan, Liu Ke, Zhang Cheng, Wu Shi-Xuan, Cao Yi-Wei, Lu Guan-Yi, Song Rui, Zhuang Xiao-Mei, Li Jin, Wu Ning
Executive function, including working memory, attention and inhibitory control, is crucial for decision making, thinking and planning. Lisdexamfetamine, the prodrug of d-amphetamine, has been approved for treating attention-deficit hyperactivity disorder and binge eating disorder, but whether it improves executive function under non-disease condition, as well as the underlying pharmacokinetic and neurochemical properties, remains unclear. Here, using trial unique non-matching to location task and five-choice serial reaction time task of rats, we found lisdexamfetamine (p...
April 2024: Experimental Neurology