Zhaoliang Yu, Peng Deng, Yufeng Chen, Dezheng Lin, Shini Liu, Jinghan Hong, Peiyong Guan, Jianfeng Chen, Min-Er Zhong, Jinghong Chen, Xiaochuan Chen, Yichen Sun, Yali Wang, Peili Wang, Zerong Cai, Jason Yongsheng Chan, Yulin Huang, Rong Xiao, Yaoyu Guo, Xian Zeng, Wenyu Wang, Yifeng Zou, Qiang Yu, Ping Lan, Bin Tean Teh, Xiaojian Wu, Jing Tan
Resistance to neoadjuvant chemotherapy leads to poor prognosis of locally advanced rectal cancer (LARC), representing an unmet clinical need that demands further exploration of therapeutic strategies to improve clinical outcomes. Here, we identified a noncanonical role of RB1 for modulating chromatin activity that contributes to oxaliplatin resistance in colorectal cancer (CRC). We demonstrate that oxaliplatin induces RB1 phosphorylation, which is associated with the resistance to neoadjuvant oxaliplatin-based chemotherapy in LARC...
February 6, 2024: Proceedings of the National Academy of Sciences of the United States of America