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https://www.readbyqxmd.com/read/28334179/bayesian-distributed-lag-interaction-models-to-identify-perinatal-windows-of-vulnerability-in-children-s-health
#1
Ander Wilson, Yueh-Hsiu Mathilda Chiu, Hsiao-Hsien Leon Hsu, Robert O Wright, Rosalind J Wright, Brent A Coull
Epidemiological research supports an association between maternal exposure to air pollution during pregnancy and adverse children's health outcomes. Advances in exposure assessment and statistics allow for estimation of both critical windows of vulnerability and exposure effect heterogeneity. Simultaneous estimation of windows of vulnerability and effect heterogeneity can be accomplished by fitting a distributed lag model (DLM) stratified by subgroup. However, this can provide an incomplete picture of how effects vary across subgroups because it does not allow for subgroups to have the same window but different within-window effects or to have different windows but the same within-window effect...
February 27, 2017: Biostatistics
https://www.readbyqxmd.com/read/28333848/associations-among-behavioral-sleep-disturbance-family-functioning-and-controller-medication-adherence-in-children-with-asthma
#2
Jennifer T Sonney, Chris Segrin, Teresa M Ward
OBJECTIVE: This study examined the associations among child sleep disturbances, family functioning, and asthma controller medication adherence in school-age children with persistent asthma. METHODS: Thirty-four children aged 6 to 11 years and a parent independently reported on asthma control and controller medication adherence. Parents also reported on family functioning (behavior control) and child sleep disturbances (bedtime resistance, daytime sleepiness). Hierarchical linear regression models tested sleep disturbance variables as predictors of family functioning and medication adherence...
March 21, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28333691/asthma-prevalence-and-severity-in-low-resource-communities
#3
Álvaro A Cruz, Rafael Stelmach, Eduardo V Ponte
PURPOSE OF REVIEW: The prevalence of asthma was thought to be low in most low-income countries, but several reports have indicated this is not always true. This is a narrative review of recent publications on the burden of asthma in low and middle-income countries (LMIC) and underprivileged communities from developed countries. RECENT FINDINGS: Several studies have reported a low prevalence of asthma is LMIC, but indicate it is increasing. In the last few years, however, many surveys demonstrated this may not always be true...
March 22, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28333531/randomized-controlled-trial-of-triple-p-for-parents-of-children-with-asthma-or-eczema-effects-on-parenting-and-child-behavior
#4
Alina Morawska, Amy Mitchell, Scott Burgess, Jennifer Fraser
OBJECTIVE: Parents play an important role in children's illness management, in promoting child adjustment and reducing behavior problems. Little research has focused on the evaluation of parenting interventions in the context of childhood chronic illness. The aim of this study was to test the efficacy of a brief, group parenting intervention (Healthy Living Triple P) in improving parenting skills and parent adjustment, and reducing child behavioral and emotional difficulties in the context of childhood asthma and eczema...
April 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28332939/pediatric-asthma-hospitalizations-among-urban-minority-children-and-the-continuity-of-primary-care
#5
Levon H Utidjian, Alexander G Fiks, A Russell Localio, Lihai Song, Mark J Ramos, Ron Keren, Louis M Bell, Robert W Grundmeier
OBJECTIVE: To examine the effect of ambulatory health care processes on asthma hospitalizations. METHODS: A retrospective cohort study using electronic health records was completed. Patients aged 2-18 years receiving health care from 1 of 5 urban practices between Jan 1, 2004 and Dec 31, 2008 with asthma documented on their problem list were included. Independent variables were modifiable health care processes in the primary care setting: (1) use of asthma controller medications; (2) regular assessment of asthma symptoms; (3) use of spirometry; (4) provision of individualized asthma care plans; (5) timely influenza vaccination; (6) access to primary healthcare; and (7) use of pay for performance physician incentives...
February 25, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28332884/asthma-control-in-london-secondary-school-children
#6
Katherine Harris, Gioia Mosler, Samson A Williams, Abigail Whitehouse, Rosalind Raine, Jonathan Grigg
OBJECTIVE: The asthma control test (ACT) is a validated tool for assessing control in asthmatic children aged 12 years and older. Using the ACT, we sought to assess asthma control and knowledge in London secondary school children. METHODS: Secondary schools in London, UK, participated in this study. Children with doctor-diagnosed asthma were invited to complete an online questionnaire that included the ACT and questions about asthma. Suboptimal asthma control was defined as an ACT score of ≤ 19 out of a maximum score of 25...
March 23, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28332418/asthma-status-is-an-independent-risk-factor-for-herpes-zoster-in-children-a-population-based-cohort-study
#7
Su-Jing Chen, Kuang-Hua Huang, Wen-Chen Tsai, Cheng-Li Lin, Yih-Dih Cheng, Chang-Ching Wei
The literature regarding the effects of childhood asthma on the risk of herpes zoster (HZ) is very limited. The aim of this study is to investigate the risks of children developing HZ with asthma. From the National Health Insurance Research Database, a total of 600,891 children were enrolled in this study between 2000 and 2007. The children were matched by age, gender, level of urbanization, and parental occupation. All subjects were followed until the end of 2008. A Cox model was used to estimate the association of asthma on the risk of HZ...
March 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28331347/environmental-triggers-and-avoidance-in-the-management-of-asthma
#8
REVIEW
Clarisse Gautier, Denis Charpin
Identifying asthma triggers forms the basis of environmental secondary prevention. These triggers may be allergenic or nonallergenic. Allergenic triggers include indoor allergens, such as house dust mites (HDMs), molds, pets, cockroaches, and rodents, and outdoor allergens, such as pollens and molds. Clinical observations provide support for the role of HDM exposure as a trigger, although avoidance studies provide conflicting results. Molds and their metabolic products are now considered to be triggers of asthma attacks...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28331103/two-cases-of-young-children-with-acute-severe-asthma-treated-by-noninvasive-positive-pressure-ventilation-via-a-helmet
#9
Yuko Amimoto, Naoko Tamura, Natsuki Kitaura, Osamu Hirata, Osamu Arashin, Masakuni Wago
We used noninvasive positive pressure ventilation (NPPV) with a helmet-type mask in two young children with acute severe bronchial asthma. The intervention was well-tolerated, because the helmet-type mask caused no pain or discomfort, as compared to the face mask. Tracheal intubation can be avoided by the start of the NPPV. Thus, the respiratory symptoms improved by the use of NPPV in children with acute severe asthma with respiratory muscle fatigue and failure of medical treatment.
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28330941/nurse-driven-clinical-pathway-for-inpatient-asthma-a-randomized-controlled-trial
#10
Catherine M Pound, Victoria Gelt, Salwa Akiki, Kaylee Eady, Katherine Moreau, Franco Momoli, Barbara Murchison, Roger Zemek, Brett Mulholland, Tom Kovesi
OBJECTIVE: We examined the impact of a nurse-driven clinical pathway on length of stay (LOS) for children hospitalized with asthma. METHODS: We conducted a randomized controlled trial involving children hospitalized with asthma. Nurses of children in the intervention group weaned salbutamol frequency using an asthma scoring tool, whereas physicians weaned salbutamol frequency for the control group patients as per standard care. The primary outcome was LOS in hours...
March 22, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28328807/associations-of-il-4-il-6-and-il-12-levels-in-peripheral-blood-with-lung-function-cellular-immune-function-and-quality-of-life-in-children-with-moderate-to-severe-asthma
#11
Ai-Hua Cui, Jing Zhao, Shu-Xiang Liu, Ying-Shuang Hao
BACKGROUND: Pediatric asthma has gained increasing concerns with poorly understood pathogenesis. The purpose of this study was to explore the associations of interleukin-4 (IL-4), IL-6, and IL-12 levels in peripheral blood (PB) with lung function, cellular immune function, and children's quality of life (QOL) with moderate-to-severe asthma. METHODS: A total of 1158 children with moderate-to-severe asthma (the experimental group) and 1075 healthy children (the control group) were recruited for our study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28327377/community-acquired-rhinovirus-infection-is-associated-with-changes-in-the-airway-microbiome
#12
Kirsten M Kloepfer, Vishal K Sarsani, Valeriy Poroyko, Wai Ming Lee, Tressa E Pappas, Theresa Kang, Kristine A Grindle, Yury A Bochkov, Sarath Chandra Janga, Robert F Lemanske, James E Gern
In school-age children with asthma, RV infection changes the upper airway microbiome and these changes are associated with symptom severity and viral load.
March 18, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28326908/sublingual-immunotherapy-tablets-as-a-disease-modifying-add-on-treatment-option-to-pharmacotherapy-for-allergic-rhinitis-and-asthma
#13
Stephen Brunton, Harold S Nelson, David I Bernstein, Simon Lawton, Susan Lu, Hendrik Nolte
Allergic rhinitis (AR) with or without conjunctivitis (AR/C) is associated with a significant health and economic burden, and is often accompanied by asthma. Pharmacotherapies are the mainstay treatment options for AR and asthma, but guidelines also recommend allergy immunotherapy (AIT). Unlike pharmacotherapies, AIT has the ability to modify the underlying immunologic mechanisms of AR and asthma with the potential for long-term benefits after treatment is discontinued. Immunotherapy may also prevent progression of AR/C to asthma...
March 22, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28326466/a-cost-minimisation-analysis-comparing-sublingual-immunotherapy-to-subcutaneous-immunotherapy-for-the-treatment-of-house-dust-mite-allergy-in-a-swedish-setting
#14
Åse Björstad, Lars-Olaf Cardell, Julie Hahn-Pedersen, Mikael Svärd
BACKGROUND AND OBJECTIVES: In Sweden, approximately 6% of children and 10% of adults suffer from house dust mite (HDM) allergy with symptoms of allergic rhinitis and allergic asthma. Treatment is aimed at reducing HDM exposure and to control the symptoms of allergic rhinitis and allergic asthma by symptom-relieving pharmacotherapy. This pharmacotherapy is often effective, but some patients remain inadequately controlled. For these patients, allergy immunotherapy (AIT, subcutaneous or sublingual) with repeated administration of HDM allergen should be considered...
March 22, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28325776/noninvasive-respiratory-support-during-pediatric-ground-transport-implementation-of-a-safe-and-feasible-procedure
#15
Nuria Millán, Carme Alejandre, Aina Martinez-Planas, Josep Caritg, Elisabeth Esteban, Martí Pons-Òdena
BACKGROUND: The purpose of this work was to determine the safety and feasibility of noninvasive support in children with acute respiratory failure (ARF) during interhospital ground transport. METHODS: This was a prospective, single-center observational clinical study in the pediatric transport unit of a tertiary-care pediatric hospital. We included all subjects with ARF transported from November 2010 to March 2013. A specific noninvasive support protocol was used for all cases...
March 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28321937/ultrafine-particles-and-black-carbon-personal-exposures-in-asthmatic-and-non-asthmatic-children-at-school-age
#16
Pau Pañella, Maribel Casas, David Donaire-Gonzalez, Raquel Garcia-Esteban, Oliver Robinson, Antònia Valentín, John Gulliver, Isabelle Momas, Mark Nieuwenhuijsen, Martine Vrijheid, Jordi Sunyer
Traffic-related air pollution (TRAP) exposure during childhood is associated with asthma; however, the contribution of the different TRAP pollutants in each microenvironment (home, school, transportation, others) in asthmatic and non-asthmatic children is unknown. Daily (24 h) personal black carbon (BC), ultrafine particles (UFP), and alveolar lung deposited surface area (LDSA) individual exposure measurements were obtained from 100 children (29 past and 21 current asthmatics, 50 non-asthmatics) aged 9±0.7 years from the INMA-Sabadell cohort (Catalonia, Spain)...
March 20, 2017: Indoor Air
https://www.readbyqxmd.com/read/28319180/effect-of-outdoor-air-pollution-on-asthma-exacerbations-in-children-and-adults-systematic-review-and-multilevel-meta-analysis
#17
Pablo Orellano, Nancy Quaranta, Julieta Reynoso, Brenda Balbi, Julia Vasquez
BACKGROUND: Several observational studies have suggested that outdoor air pollution may induce or aggravate asthma. However, epidemiological results are inconclusive due to the presence of numerous moderators which influence this association. The goal of this study was to assess the relationship between outdoor air pollutants and moderate or severe asthma exacerbations in children and adults through a systematic review and multilevel meta-analysis. MATERIAL AND METHODS: We searched studies published in English on PubMed, Scopus, and Google Scholar between January 2000 and October 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28318051/atopic-dermatitis-in-israeli-adolescents-from-1998-to-2013-trends-in-time-and-association-with-migraine
#18
Rony Shreberk-Hassidim, Ayal Hassidim, Yoav Gronovich, Adam Dalal, Vered Molho-Pessach, Abraham Zlotogorski
BACKGROUND: Recent data have shown an increasing occurrence of atopic dermatitis (AD) in children and adolescents, as well as in adults. Most of the epidemiologic research on AD is limited to pediatric and youth populations and is based on self-reported questionnaires. METHODS: A nationwide, population-based, cross-sectional retrospective study of adolescents with AD was performed to estimate its prevalence, trends, and association with demographic factors and comorbidities...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28316098/therapeutic-options-for-dysfunctional-breathing-in-children-and-adolescents
#19
Bodo Niggemann, Christine Lehmann, Dorothea Pfeiffer-Kascha, Christa Weiss
Dysfunctional breathing is common and represents important differential diagnoses for respiratory discomfort. Typical examples include habit cough, sighing dyspnoea, hyperventilation syndrome, dysfunctional breathing patterns or vocal cord dysfunction (1,2). Comorbidities are frequent, especially with bronchial asthma. In some cases dysfunctional breathing may be a sequelae of child neglect or abuse. This article is protected by copyright. All rights reserved.
March 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28306629/management-of-acute-asthma-exacerbations
#20
Erin K Stenson, Michael J Tchou, Derek S Wheeler
PURPOSE OF REVIEW: Herein, we review the current guidelines for the management of children with an acute asthma exacerbation. We focus on management in the emergency department, inpatient, and ICU settings. RECENT FINDINGS: The most recent statistics show that the prevalence of asthma during childhood has decreased in certain demographic subgroups and plateaued in other subgroups. However, acute asthma accounts for significant healthcare expenditures. Although there are few, if any, newer therapeutic agents available for management of acute asthma exacerbations, several reports leveraging quality improvement science have shown significant reductions in costs of care as well as improvements in outcome...
March 16, 2017: Current Opinion in Pediatrics
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