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https://www.readbyqxmd.com/read/28732433/the-effect-of-salt-space-on-clinical-findings-and-peak-expiratory-flow-in-children-with-mild-to-moderate-asthma-a-randomized-crossover-trial
#1
Saeideh Mazloomzadeh, Niousha Bakhshi, Akefeh Ahmadiafshar, Mehdi Gholami
The asthma treatment and control might be associated with significant burden on family and community' thus exploring other therapeutic plans could be desirable. The aim of this study was to investigate the effect of salt space on clinical findings and peak expiratory flow rate among children with asthma. In this randomized crossover trial, 34 patients aged 6-14 years old with mild to moderate asthma were selected and randomly divided into two groups. The first group went through a period of salt therapy by staying in the salt room for one hour, three times a week for 3 consecutive weeks and then was under observation for three weeks...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28732397/combined-sewer-overflow-events-and-childhood-emergency-department-visits-a-case-crossover-study
#2
Cole Brokamp, Andrew F Beck, Louis Muglia, Patrick Ryan
In localities with combined sewer systems, combined sewer overflow (CSO) events frequently occur following high precipitation and can result in the release of untreated sewage and industrial wastewater into surface waters. We hypothesized that either direct contact with or proximity to aerosolized CSO effluent would increase the risk for childhood emergency department (ED) visits for asthma, gastrointestinal (GI) illnesses, and skin and soft tissue infections (SSTIs) in Cincinnati, OH, USA. ED visits for 2010-2014 due to GI diseases, asthma, and SSTIs were extracted from the Cincinnati Children's Hospital Medical Center electronic health records...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28730377/influence-of-vitamin-d-and-cotinine-on-t-regulatory-cells-and-asthma-severity-in-children
#3
Bolesław Kalicki, Agata Wawrzyniak, Agnieszka Lipińska-Opałka, Sławomir Lewicki, Robert Zdanowski
Asthma is a common chronic respiratory diseases in children. Understanding the immune mechanisms of epigenetic factors may contribute to a better control of asthma. This study seeks to determine the effects of serum vitamin D and urine cotinine on asthma severity and on T regulatory cells (Tregs) and other immune-related factors such as CD3, CD4, CD8, CD19, CD16/56, and anti-CD3 HLA-DR3. The study involved 34 children with asthma. Disease severity was assessed with the Asthma Control Test, spirometry, and the fractional exhaled nitric oxide (FeNO)...
July 21, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28729819/secondhand-smoke-exposure-and-risk-of-wheeze-in-early-childhood-a-prospective-pregnancy-birth-cohort-study
#4
Keiko Tanaka, Yoshihiro Miyake, Shinya Furukawa, Masashi Arakawa
BACKGROUND: Evidence regarding the independent and additive effects of both pre- and postnatal smoking exposure on the risk of wheeze in children is limited. The purpose of this prospective pregnancy birth cohort study was to examine the association between prenatal and postnatal tobacco smoke exposure during the first year of life and the risk of wheeze in Japanese children aged 23 to 29 months. METHODS: Study subjects were 1354 Japanese mother-child pairs. Information on the variables under study was obtained using repeated questionnaires that were completed by mothers, first prior to delivery, then shortly after birth and subsequently around 4, 12, and 24 months after delivery...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28728259/-impact-of-allergic-airway-diseases-on-risk-of-attention-deficit-hyperactivity-disorder-in-school-age-children
#5
X D Jiang, C Shen, K Li, Y T Ji, S H Li, F Jiang, X M Shen, F Li, Y Hu
Objective: To investigate the impact of allergic airway diseases on the risk of attention deficit hyperactivity disorder (ADHD) in school-age children. Method: Used stratified cluster sampling method, school-age children in first to sixth grade in primary schools in 9 randomly selected cities including Shanghai, Guangzhou, Xi'an, and Wuhan were enrolled in the study. Interview of parents with questionnaires, which included school-age individual and family social environment questionnaire (including history of diagnosed ADHD, allergic rhinitis, and bronchial asthma) and Children's Sleep Habits Questionnaire (CSHQ), were finished and collected during November to December in 2005...
July 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28725641/mechanisms-mediating-pediatric-severe-asthma-and-potential-novel-therapies
#6
REVIEW
Aldara Martin Alonso, Sejal Saglani
Although a rare disease, severe therapy-resistant asthma in children is a cause of significant morbidity and results in utilization of approximately 50% of health-care resources for asthma. Improving control for children with severe asthma is, therefore, an urgent unmet clinical need. As a group, children with severe asthma have severe and multiple allergies, steroid resistant airway eosinophilia, and significant structural changes of the airway wall (airway remodeling). Omalizumab is currently the only add-on therapy that is licensed for use in children with severe asthma...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28724478/the-stoppa-twin-study-explains-the-exhaled-nitric-oxide-and-asthma-link-by-genetics-and-sensitization
#7
Björn Nordlund, Cecilia Lundholm, Vilhelmina Ullemar, Marianne van Hage, Anne K Örtqvist, Catarina Almqvist
BACKGROUND: The link between asthma and exhaled nitric oxide (FENO) is not completely understood. The aim of this study was to estimate the association between FENO and asthma, taking genetics, sensitization, and inhaled corticosteroids (ICS) into account. METHODS: A total of 681 twins (53% monozygotic [MZ] and 47% dizygotic [DZ]) from the population-based STOPPA study (mean age 12.6 years) were recruited and information on FENO (parts per billion), parental report of current asthma, sensitization to airborne allergens (Phadiatop; IgE ≥0...
August 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28724400/detection-of-il-9-producing-t-cells-in-the-pbmcs-of-allergic-asthmatic-patients
#8
Lei Jia, Ying Wang, Jiangping Li, Sha Li, Yannan Zhang, Juan Shen, Weiping Tan, Changyou Wu
BACKGROUND: Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS: We isolated peripheral blood mononuclear cells from children with allergic asthma and healthy children. IL-9, IL-4 and IFN-γ expression were detected by ELISA, ELISpot and Flowcytometry. Expression of transcription factor PU...
July 19, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28723552/immunology-of-food-allergy
#9
REVIEW
Leticia Tordesillas, M Cecilia Berin, Hugh A Sampson
Many consider food allergy as the "second wave" of the allergy epidemic following the "first wave" of respiratory allergy, i.e., asthma and allergic rhinitis, plaguing westernized countries, with up to 8% of young children and 2%-3% of adults in the United States now affected by hypersensitivity reactions to various foods. In the past decade, there have been great strides in our understanding of the underlying immunopathogenesis of these disorders, which have led to improved diagnostic techniques, management strategies, and therapeutic approaches...
July 18, 2017: Immunity
https://www.readbyqxmd.com/read/28722791/treatment-evaluation-using-lung-sound-analysis-in-asthmatic-children
#10
Chizu Habukawa, Katsumi Murakami, Mitsuru Endoh, Noriaki Horii, Yukio Nagasaka
BACKGROUND AND OBJECTIVE: Non-invasive assessment of treatment and prediction of attacks in asthmatic children do not yet exist. Lung sound analysis can non-invasively evaluate airway obstruction. We used a recently developed technology for analysing lung sounds using ic700 (index of the chest wall at 700 Hz, sound intensity at 700 Hz) to evaluate response to inhaled corticosteroid (ICS) in asthmatic children. METHOD: Seventy asthmatic children, including infants, underwent lung sound recording in the asymptomatic state prior to and 1, 2, 4, 6 and 8 weeks after ICS treatment, and asthma control was assessed at 10 weeks...
July 19, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28719788/asthma-control-and-care-among-malaysian-primary-school-children-a-cross-sectional-study
#11
Azainorsuzila Ahad, Ee Ming Khoo
Children with uncontrolled asthma have high risk of poor health outcomes. The aim of this study was to assess asthma control and care in primary school children with reported asthma. A total of 6441 primary school children were first screened for parent-reported physician-diagnosed asthma and 448 (8.9%) children were reported to have asthma. Of these, 311 (69.4%) parents agreed to participate in assessment of asthma control study using Global Initiative for Asthma 2009 guidelines. Only 161 (51.8%) children were found to have good asthma control, 99 (31...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28719626/impact-of-respiratory-infections-outdoor-pollen-and-socioeconomic-status-on-associations-between-air-pollutants-and-pediatric-asthma-hospital-admissions
#12
Julie E Goodman, Christine T Loftus, Xiaobin Liu, Ke Zu
BACKGROUND: Epidemiology studies have shown that ambient concentrations of ozone and fine particulate matter (PM2.5) are associated with increased emergency department (ED) visits and hospital admissions (HAs) for asthma. OBJECTIVE: Evaluate the impact of outdoor pollen, respiratory infections, and socioeconomic status (SES) on the associations between ambient ozone and PM2.5 and asthma HAs in New York City. METHODS: Daily ozone, PM2.5, meteorological factors, pollen, and hospitalization records during 1999 to 2009 were obtained for New York City residents...
2017: PloS One
https://www.readbyqxmd.com/read/28719502/safety-of-quadrivalent-meningococcal-conjugate-vaccine-in-children-2-10-years
#13
Sara Y Tartof, Lina S Sy, Bradley K Ackerson, Rulin C Hechter, Mendel Haag, Jeffrey M Slezak, Yi Luo, Christine A Fischetti, Harp S Takhar, Yan Miao, Zendi Solano, Steven J Jacobsen, Hung-Fu Tseng
BACKGROUND: Quadrivalent meningococcal conjugate vaccine is recommended for children, adolescents, and adults at increased risk of meningococcal disease. In 2011, MenACWY-CRM (Menveo, GSK) was approved for children aged 2-10 years in the U.S. Although no safety concerns arose from clinical trials, it remains important to monitor its safety in routine clinical settings. METHODS: Kaiser Permanente Southern California members 2-10 years old who received MenACWY-CRM between September 2011 and September 2014 were included...
July 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28716644/muc5ac-and-a-glycosylated-variant-of-muc5b-alter-mucin-composition-in-children-with-acute-asthma
#14
Kathryn G Welsh, Karine Rousseau, Gemma Fisher, Luke R Bonser, Peter Bradding, Chris E Brightling, David J Thornton, Erol A Gaillard
BACKGROUND: Diffuse airway mucus obstruction is an important feature of severe and fatal asthma. MUC5AC and MUC5B are the principal gel-forming mucins found in airway mucus. The mucin composition of airway mucus likely affects its functional properties. METHODS: We quantified the principal airway mucins MUC5AC and MUC5B in the sputum of age-matched children with acute and stable asthma and healthy controls using Western blotting. RESULTS: Sputum samples from 38 children (13 acute asthma, 15 stable asthma, 10 controls) were obtained...
July 14, 2017: Chest
https://www.readbyqxmd.com/read/28713805/the-benefits-and-challenges-of-managing-asthma-in-hispanic-families-in-south-texas-a-mixed-methods-study
#15
Genny Carrillo, Maria J Perez-Patron, Rose L Lucio, Lucia Cabrera, Alyssa Trevino, Xiaohui Xu, Nelda Mier
BACKGROUND: Understanding the experience of Hispanic parents of children diagnosed with asthma can be useful in the delivery of effective and meaningful asthma education. In order to assess the needs of Hispanic families with asthmatic children in South Texas, investigators utilized a combination of qualitative and quantitative research methods. OBJECTIVES: This study aimed (1) to assess the impact of asthma in the quality of life of Hispanic children and their families and (2) to identify barriers and challenges to asthma management as perceived by parents of children diagnosed with asthma...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28713081/gene-polymorphism-of-xenobiotic-detoxification-in-children-with-bronchial-asthma
#16
Liudmila Y Lytvynets
INTRODUCTION: Children are the most susceptible to harmful external factors due to the incomplete development of all functional body systems. The ecological situation the problem of influence of genetic and environmental factors on the pathogenesis of chronic respiratory diseases in children and its investigation is very impotent today. Among it the bronchial asthma is a leader among bronchial and pulmonary diseases caused by the influence of pneumotropic pollutants. The aim of our research was to study the phenotypic characteristics of asthma in Pre-Carpathian children with different types of allelic gene polymorphism of the first phase of xenobiotic detoxification of microsomal epoxide hydrolases (mEPHX1)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28712803/maternal-asthma-severity-and-control-during-pregnancy-and-risk-of-offspring-asthma
#17
Xiaoqin Liu, Esben Agerbo, Vivi Schlünssen, Rosalind J Wright, Jiong Li, Trine Munk-Olsen
BACKGROUND: Severe and uncontrolled asthma during pregnancy has been linked to several unfavorable perinatal outcomes. However, current knowledge on the association between the severity and control of maternal asthma and offspring asthma is sparse. OBJECTIVE: We sought to investigate the extent to which offspring asthma is influenced by maternal asthma severity and control during pregnancy. METHODS: We performed a prospective population-based cohort study...
June 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28710850/efficacy-and-safety-of-beclomethasone-dipropionate-breath-actuated-or-metered-dose-inhaler-in-pediatric-patients-with-asthma
#18
M Vandewalker, L Hickey, C J Small
BACKGROUND: Breath-actuated inhalers (BAI) eliminate the need for hand-breath coordination and, therefore, simplify thedelivery of inhaled medication. OBJECTIVE: To evaluate the efficacy and safety of beclomethasone dipropionate BAI and metered-dose inhaler (MDI) versus placebo in pediatric patients ages 4-11 years with persistent asthma. METHODS: In this double-blind, double-dummy, phase III study, 628 children with persistent asthma were randomly assigned(1:1:1:1:1) to twice-daily beclomethasone dipropionate (BAI 80 micrograms/day, BAI 160 micrograms/day, MDI 80 micrograms/day, or MDI 160 micrograms/day) or to placebo...
July 14, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28710699/examining-early-childhood-health-outcomes-of-children-born-late-preterm-in-urban-manitoba
#19
Leah K Crockett, Marni D Brownell, Maureen I Heaman, Chelsea A Ruth, Heather J Prior
Objective The late preterm population [34-36 weeks gestational age (GA)] is known to incur increased morbidity in the infancy stage compared to the population born at term (39-41 weeks GA). This study aimed to examine the health of these children during their early childhood years, with specific attention to the role of socioeconomic status. Methods A retrospective cohort study was conducted using data from the Manitoba Centre for Health Policy, including all live-born children born at 34-36 and 39-41 weeks GA in urban Manitoba between 2000 and 2005 (n = 28,100)...
July 14, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28709967/advances-in-asthma-2016-designing-individualized-approaches-to-management
#20
William C Anderson, Andrea Apter, Cullen M Dutmer, Daniel A Searing, Stanley J Szefler
In this years Advances in Asthma review we discuss viral infections in asthma and potential therapeutic agents, the microbiome, novel genetic associations with asthma, air quality and climate effects on asthma, exposures during development and long term sequelae of childhood asthma, patient centered outcome research, and precision medicine. In addition, we discuss application of biomarkers to precision medicine, and new information on asthma medications. New evidence indicates that rhinovirus-triggered asthma exacerbations become more severe as the degree of sensitization to dust mite and mouse increase...
July 11, 2017: Journal of Allergy and Clinical Immunology
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